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https://www.readbyqxmd.com/read/29468762/hypolipidemic-activity-and-mechanisms-of-the-total-phenylpropanoid-glycosides-from-ligustrum-robustum-roxb-blume-by-ampk-srebp-1c-pathway-in-hamsters-fed-a-high-fat-diet
#1
Runmei Yang, Xinxin Chu, Le Sun, Zhuoying Kang, Min Ji, Ying Yu, Ying Liu, Zhendan He, Nannan Gao
The aim of this study was to evaluate the hypolipidemic effect and mechanisms of total phenylpropanoid glycosides extracted from Ligustrum robustum (Roxb.) Blume (LRTPG) in hamsters fed a high-fat diet and to discover bioactive components in HepG2 cell model induced by oleic acid. LRTPG of high (1.2 g/kg), medium (0.6 g/kg), and low (0.3 g/kg) doses was administrated daily for 21 consecutive days in hamsters. We found that in hamsters fed a high-fat diet, LRTPG effectively reduced the concentrations of plasma triglycerides (TG), free fatty acid, total cholesterol, low-density lipoprotein cholesterol, and hepatic TG and total cholesterol...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29467759/magnolol-alleviates-inflammatory-responses-and-lipid-accumulation-by-amp-activated-protein-kinase-dependent-peroxisome-proliferator-activated-receptor-%C3%AE-activation
#2
Ye Tian, Haihua Feng, Lu Han, Lin Wu, Hongming Lv, Bingyu Shen, Zheng Li, Qiaoling Zhang, Guowen Liu
Magnolol (MG) is a kind of lignin isolated from Magnolia officinalis , which serves several different biological functions, such as antifungal, anticancer, antioxidant, and hepatoprotective functions. This study aimed to evaluate the protective effect of MG against oleic acid (OA)-induced hepatic steatosis and inflammatory damage in HepG2 cells and in a tyloxapol (Ty)-induced hyperlipidemia mouse model. Our findings indicated that MG can effectively inhibit OA-stimulated tumor necrosis factor α (TNF-α) secretion, reactive oxygen species generation, and triglyceride (TG) accumulation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467588/pulmonary-arterial-enlargement-is-associated-with-acute-chest-pain-in-patients-without-obstructive-coronary-artery-disease
#3
Narasa Madam, Wassim Mosleh, Natdanai Punnanithinont, Andres Carmona-Rubio, Zaid H Said, Umesh C Sharma
Background: Pulmonary hypertension (PH) is an underdiagnosed cause for chest pain in patients without significant coronary artery disease (CAD). Studies showed that enlarged pulmonary arterial (PA) and right ventricular chamber sizes correlate with the severity of PH. Therefore, we studied the association between chest pain, right ventricular dimensions (RVDs), and PA size on coronary coronary tomographic angiography (CCTA). Methods: The CCTA of 87 patients presenting with chest pain without evidence of obstructive CAD was examined...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/29467330/inducible-podocyte-specific-deletion-of-ctcf-drives-progressive-kidney-disease-and-bone-abnormalities
#4
Marta Christov, Abbe R Clark, Braden Corbin, Samy Hakroush, Eugene P Rhee, Hiroaki Saito, Dan Brooks, Eric Hesse, Mary Bouxsein, Niels Galjart, Ji Yong Jung, Peter Mundel, Harald Jüppner, Astrid Weins, Anna Greka
Progressive chronic kidney diseases (CKDs) are on the rise worldwide. However, the sequence of events resulting in CKD progression remain poorly understood. Animal models of CKD exploring these issues are confounded by systemic toxicities or surgical interventions to acutely induce kidney injury. Here we report the generation of a CKD mouse model through the inducible podocyte-specific ablation of an essential endogenous molecule, the chromatin structure regulator CCCTC-binding factor (CTCF), which leads to rapid podocyte loss (iCTCFpod-/-)...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29464380/the-metabolic-and-endocrine-characteristics-in-spinal-and-bulbar-muscular-atrophy
#5
Angela Rosenbohm, Susanne Hirsch, Alexander E Volk, Torsten Grehl, Julian Grosskreutz, Frank Hanisch, Andreas Herrmann, Katja Kollewe, Wolfram Kress, Thomas Meyer, Susanne Petri, Johannes Prudlo, Carsten Wessig, Hans-Peter Müller, Jens Dreyhaupt, Jochen Weishaupt, Christian Kubisch, Jan Kassubek, Patrick Weydt, Albert C Ludolph
OBJECTIVE: Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for the selection of biomarkers for future therapeutic trials. METHODS: We assessed a panel of 28 laboratory parameters. The clinical course and blood biomarkers were correlated with disease duration and CAG repeat length...
February 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29462515/risk-factor-for-diabetes-mellitus-and-high-blood-glucose-with-hmg-coa-reductase-inhibitors-using-a-postmarketing-surveillance-database-in-japan
#6
Masayuki Hashiguchi, Junya Maruyama, Mikiko Shimizu, Daichi Takahashi, Tsuyoshi Shiga
To investigate whether 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (statin) use is associated with an increased risk of diabetes mellitus and hyperglycemia, we performed a nested case-control study using a postmarketing surveillance database in Japan. The database cohort included 26,849 cases of statin use and 5308 cases of other lipid-lowering drug use in patients with hyperlipidemia. Participants received at least 1 type of statin, had a clear medication history of statin use, and had no complications of diabetes mellitus...
February 20, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29459831/relative-handgrip-strength-is-inversely-associated-with-metabolic-profile-and-metabolic-disease-in-the-general-population-in-china
#7
Dongxue Li, Guanghong Guo, Lili Xia, Xinghua Yang, Biao Zhang, Feng Liu, Jingang Ma, Zhiping Hu, Yajun Li, Wei Li, Jiajia Jiang, Herbert Gaisano, Guangliang Shan, Yan He
Background: Absolute handgrip strength has been correlated with metabolic profile and metabolic disease. Whether relative handgrip strength is also associated with metabolic disease has not been assessed. This study aimed at assessing the association of relative handgrip strength with metabolic profile and metabolic disease in the general population in China. Methods: Data were derived from an ongoing cross-sectional survey of the 2013 National Physical and Health in Shanxi Province, which involved 5520 participants...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29459462/sex-difference-in-patients-with-ischemic-heart-failure-undergoing-surgical-revascularization-results-from-the-stich-trial-surgical-treatment-for-ischemic-heart-failure
#8
Ileana L Piña, Qi Zheng, Lilin She, Hanna Szwed, Irene M Lang, Pedro S Farsky, Serenella Castelvecchio, Jolanta Biernat, Alexandros Paraforos, Dragana Kosevic, Liliana E Favaloro, José C Nicolau, Padmini Varadarajan, Eric J Velazquez, Ramdas G Pai, Nicole Cyrille, Kerry L Lee, Patrice Desvigne-Nickens
BACKGROUND: Female sex is conventionally considered a risk factor for coronary artery bypass grafting (CABG) and has been included as a poor prognostic factor in multiple cardiac operative risk evaluation scores. We aimed to investigate the association of sex and the long-term benefit of CABG in patients with ischemic left ventricular dysfunction enrolled in the prospective STICH trial (Surgical Treatment for Ischemic Heart Failure Study). METHODS: The STICH trial randomized 1212 patients (148 [12%] women and 1064 [88%] men) with coronary artery disease and left ventricular ejection fraction ≤35% to CABG+medical therapy (MED) versus MED alone...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29459263/hyperlipidemia-induces-typical-atherosclerosis-development-in-ldlr-and-apoe-deficient-rats
#9
Yongliang Zhao, Yiqing Yang, Roumei Xing, Xueqin Cui, Yufang Xiao, Ling Xie, Panpan You, Tongtong Wang, Li Zeng, Wenhui Peng, Dali Li, Huaqing Chen, Mingyao Liu
BACKGROUND AND AIMS: Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe) knockout (KO) mice have been widely used as animal models of atherosclerosis. However, data suggested that it is difficult to develop typical atherosclerosis in rats. To this end, Ldlr and Apoe KO rats were generated and the potential to develop novel atherosclerosis models was evaluated. METHODS: We established Apoe/Ldlr single and double KO (DKO) rats via the CRISPR/Cas9 system in the same background...
February 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29459257/effect-of-comorbidities-on-the-course-of-multiple-sclerosis
#10
Przemyslaw Puz, Anetta Lasek-Bal, Arkadiusz Steposz, Karina Bartoszek, Patrycja Radecka
OBJECTIVE: The clinical condition of multiple sclerosis (MS) patients depends not only on the course of MS but also on their lifestyle and comorbidities. This study aimed to assess the effect of selected comorbidities, lifestyle-related factors and clinical data available at the time of MS diagnosis, on the disease activity and the disability progression in patients with relapsing-remitting multiple sclerosis (RRMS). PATIENTS AND METHODS: Based on clinical relapses over a period of 12 months of observation and the results of MRI scans, 138 patients with RRMS were qualified into two groups: 'active' or 'stable' course of the disease...
February 11, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29459241/the-atherogenic-dyslipidemia-complex-and-novel-approaches-to-cardiovascular-disease-prevention-in-diabetes
#11
REVIEW
Priska Stahel, Changting Xiao, Robert A Hegele, Gary F Lewis
Despite the effectiveness of low-density lipoprotein (LDL)-lowering strategies for the treatment of diabetic dyslipidemia, significant residual risk of atherosclerotic cardiovascular disease remains. Residual risk might in part be explained by lipid abnormalities that go beyond LDL cholesterol elevation, collectively termed the "atherogenic dyslipidemia complex (ADC)," consisting of hypertriglyceridemia, elevated small dense LDL particles, reduced high-density lipoprotein cholesterol, and high-density lipoprotein particle numbers, increased remnant lipoproteins, and postprandial hyperlipidemia...
December 15, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29458386/functional-improvements-in-patients-with-lymphangioleiomyomatosis-after-sirolimus-an-observational-study
#12
Yongzhong Zhan, Lisha Shen, Wenshuai Xu, Xiuxiu Wu, Weihong Zhang, Jun Wang, Xue Li, Yanli Yang, Xinlun Tian, Kai-Feng Xu
BACKGROUND: Sirolimus has been shown to be effective in patients with lymphangioleiomyomatosis (LAM). We wish to summarize our experience using sirolimus and its effectiveness in LAM patients. METHODS: We analyzed data from 98 patients who were diagnosed with definite or probable sporadic LAM based on the European Respiratory Society diagnosis criteria for LAM in 2010 at Peking Union Medical College Hospital and who had received sirolimus during January 2007 to June 2015...
February 20, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29457523/natural-products-for-controlling-hyperlipidemia-review
#13
Walid Hamdy El-Tantawy, Abeer Temraz
Hyperlipidemia is an abnormality of lipid metabolism, characterized by an elevation of total cholesterol, triglyceride, and low density lipoprotein-cholesterol, and/or a decreasing of high density lipoprotein cholesterol in circulating levels. Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. Hyperlipidemia-associated lipid disorders are considered the cause of atherosclerotic cardiovascular disease. There has been a growing interest in natural products and their role in the maintenance and improvement of health and wellness...
February 19, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29457348/fixed-dose-vs-free-dose-combinations-for-the-management-of-hypertension-an-analysis-of-81-958-patients
#14
Peter Bramlage, Stefanie Schmidt, Helen Sims
Fixed-dose combinations (FDC) have been developed to reduce the pill burden for hypertensive patients. Data on fixed-dose or free-dose (freeDC) ramipril/amlodipine (R/A) or candesartan/amlodipine (C/A) combination treatment initiation were assessed. 71 463 patients were prescribed R/A and 10 495 C/A. For both R/A and C/A, FDC patients were younger (both P < .001) and less comorbid. Prior MI (OR: 0.61 and 0.60), prior stroke (OR: 0.68 and 0.70) and CHD (OR: 0.68 and 0.64) were negatively associated with FDC use, whereas hyperlipidemia was positively associated (OR: 1...
February 19, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29453308/sex-specific-mechanisms-of-resistance-vessel-endothelial-dysfunction-induced-by-cardiometabolic-risk-factors
#15
Ana P Davel, Qing Lu, M Elizabeth Moss, Sitara Rao, Imran J Anwar, Jennifer J DuPont, Iris Z Jaffe
BACKGROUND: The incidence of obesity is rising, particularly among women. Microvascular dysfunction is more common with female sex, obesity, and hyperlipidemia and predicts adverse cardiovascular outcomes, but the molecular mechanisms are unclear. Because obesity is associated with mineralocorticoid receptor (MR) activation, we tested the hypothesis that MR in endothelial cells contribute to sex differences in resistance vessel dysfunction in response to cardiometabolic risk factors. METHODS AND RESULTS: Male and female endothelial cell-specific MR knockout mice and MR-intact littermates were randomized to high-fat-diet-induced obesity or obesity with hyperlipidemia induced by adeno-associated virus-based vector targeting transfer of the mutant stable form (DY mutation) of the human PCSK9 (proprotein convertase subtilisin/kexin type 9) gene and compared with control diet...
February 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29452699/hypolipidemic-components-from-medicine-food-homology-species-used-in-china-pharmacological-and-health-effects
#16
REVIEW
De-Xing Song, Jian-Guo Jiang
Hyperlipidemia is a systemic disease caused by abnormal human lipid metabolism. Dietary control and treatment on hyperlipidemia is now a popular therapy pathway. This paper focuses on the medicine food homology (MFH) species used in China with hypolipidemic function, and emphasizes on the active ingredients and their pharmacological effect. The single herbal and its hypolipidemic active ingredients are summarized through reviewing the relevant literatures published in the past twenty years. The ingredients are divided into polysaccharides, flavonoids, steroidal saponins, quinones, alkaloids and others, of which the related researches are described from the aspects of sources, model and method, result and mechanisms, respectively...
February 13, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29451153/effects-of-plasma-lipids-and-statins-on-cognitive-function
#17
REVIEW
Rui Li, Tian-Jun Wang, Pei-Yuan Lyu, Yang Liu, Wei-Hong Chen, Ming-Yue Fan, Jing Xu
Objective: Dementia is the fourth most common cause of death in developed countries. The relationship between plasma lipids and cognitive function is complex and controversial. Due to the increasing life expectancy of the population, there is an urgent need to control vascular risk factors and to identify therapies to prevent and treat both cognitive impairment and dementia. Here, we reviewed the effects of plasma lipids and statins on cognitive function. Data Sources: We searched the PubMed database for research articles published through November 2017 with key words including "plasma lipids," "hyperlipidemia," "hypercholesterolemia," "statins," and "cognition function...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29447824/central-xanthoma-of-the-mandible-associated-with-hyperlipidemia-a-rare-presentation
#18
John K Brooks, Behzad Mostoufi, Ahmed S Sultan, Zaid H Khoury, Jeffery B Price, John C Papadimitriou, John R Basile, Cinthia B Drachenberg, Rania H Younis
Xanthoma is a common, self-limiting cutaneous lesion of non-Langerhans cell, lipid-laden foamy histiocytes that is often concomitant with hyperlipidemia. The intraosseous counterpart is rarely encountered and typically presents as a painless, expansile osteolytic process in the context of hyperlipidemia or normolipidemia. Only a scant number of gnathic xanthomas have been reported in the otolaryngologic literature. We report the clinical, laboratory, radiographic, histopathologic, immunohistochemical, and ultrastructural studies of a mandibular lesion discovered in an asymptomatic 16-year-old male, and associated with 2 previously unreported comorbidities, namely hyperlipidemia and vitamin D deficiency...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29446047/epigallocatechin-gallate-suppresses-hepatic-cholesterol-synthesis-by-targeting-srebp-2-through-sirt1-foxo1-signaling-pathway
#19
Yongnan Li, Shuodong Wu
This study aims to explore the effect of epigallocatechin gallate (EGCG) on blood lipids, liver lipids, and cholesterol synthesis in hyperlipidemic rats. SREBP-2 transgenic rats were used to investigate the transcriptional level of SREBP-2 regulated by SIRT-1/FOXO1 and the molecular mechanism of rate-limiting enzyme HMGCR that affects cholesterol synthesis. Rat models of hyperlipidemia were established and administered EGCG. Cholesterol synthesis was observed. Enzyme linked immunosorbent assay was used to determine serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), free fatty acid (FFA), superoxide dismutase (SOD), malondialdehyde (MDA), and T-AOC contents...
February 14, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29444599/correlation-between-epicardial-fat-thickness-and-aortic-valve-sclerosis
#20
Maryam Nabati, Maryam Favaedi, Masoud Kheirgoo, Jamshid Yazdani, Mozhdeh Dabirian
Background Epicardial fat is a true visceral fat deposit with adverse effects through the secretion of numerous proinflammatory and proatherogenic cytokines. Previous studies showed an association between aortic valve sclerosis and coronary artery disease. The aim of this study was to determine the correlation between epicardial fat thickness and aortic valve sclerosis. Method The study involved 225 patients who were admitted for coronary angiography due to new-onset angina. They underwent transthoracic echocardiography and epicardial fat thickness was determined...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
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