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https://www.readbyqxmd.com/read/29230421/association-of-vitamin-d-deficiency-and-degree-of-coronary-artery-disease-in-cardiac-patients-with-type-2-diabetes
#1
Ewelina A Dziedzic, Jakub S Gąsior, Mariusz Pawłowski, Marek Dąbrowski
Several modifiable factors may influence cardiac function in diabetic patients. The aim of the study was to evaluate the influence of vitamin D level on the stage of coronary atherosclerosis in cardiac patients diagnosed with type 2 diabetes. The study was performed in 337 consecutive patients undergoing coronarography. The stage of atherosclerosis was evaluated using Coronary Artery Surgery Study Score. The plasma 25(OH)D concentration was determined by an electrochemiluminescence method. Patients without significant lesions in coronary arteries presented the highest 25(OH)D level, significantly higher than patients with one-, two-, and three-vessel coronary artery disease (CAD) (p < 0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29229235/valproic-acid-disrupts-the-oscillatory-expression-of-core-circadian-rhythm-transcription-factors
#2
Chanel A Griggs, Scott W Malm, Rosa Jaime-Frias, Catharine L Smith
Valproic acid (VPA) is a well-established therapeutic used in treatment of seizure and mood disorders as well as migraines and a known hepatotoxicant. About 50% of VPA users experience metabolic disruptions, including weight gain, hyperlipidemia, and hyperinsulinemia, among others. Several of these metabolic abnormalities are similar to the effects of circadian rhythm disruption. In the current study, we examine the effect of VPA exposure on the expression of core circadian transcription factors that drive the circadian clock via a transcription-translation feedback loop...
December 8, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29229111/toxicity-risk-from-glucocorticoids-in-sarcoidosis-patients
#3
Nauman A Khan, Christopher V Donatelli, Adriano R Tonelli, Jonathan Wiesen, Manuel L Ribeiro Neto, Debasis Sahoo, Daniel A Culver
BACKGROUND: Glucocorticoids (GC) are considered first-line therapy for treating sarcoidosis, but there are few data about the adverse consequences of GC. Although there are several steroid-sparing medications available for treatment, a large proportion of patients are treated with prolonged courses of GC. The toxicities of GC in sarcoidosis populations have not been carefully evaluated. METHODS: We performed a retrospective cohort study of all newly diagnosed sarcoidosis patients who had the entirety of their medical care in a single health system...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29228968/feces-and-liver-tissue-metabonomics-studies-on-the-regulatory-effect-of-aspirin-eugenol-eater-in-hyperlipidemic-rats
#4
Ning Ma, Xiwang Liu, Xiaojun Kong, Shihong Li, Zenghua Jiao, Zhe Qin, Pengcheng Dong, Yajun Yang, Jianyong Li
BACKGROUND: Based on the pro-drug principle, aspirin and eugenol were esterified to synthesize aspirin eugenol ester (AEE). The anti-hyperlipidemia effect of aspirin eugenol ester has been confirmed in hyperlipidemic rat induced by high fat diet (HFD). However, its effect on liver and feces metabonomic profiles remains unknown. METHODS: Suspension of AEE was prepared in 5% carboxymethyl cellulose sodium (CMC-Na). Thirty rats were divided into control, model and AEE groups...
December 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29228954/combination-of-berberine-and-evodiamine-inhibits-intestinal-cholesterol-absorption-in-high-fat-diet-induced-hyperlipidemic-rats
#5
Xin Zhou, Fengying Ren, Hong Wei, Liyun Liu, Tao Shen, Shijun Xu, Jiangping Wei, Jiayue Ren, Hengfan Ni
BACKGROUND: Hyperlipidemia characterized of elevated serum lipid levels is a prevalent disease frequently resulting in cardiovascular disease (CVD). Berberine and evodiamine are herbal products of traditional Chinese herb Coptis chinensis and Evodia rutaecarpa, which are indicated to exert regulation of lipid metabolism. Therefore, the objective of this study was to investigate the lipid-lowering effect of berberine and evodiamine combination in hyperlipidemic rats. METHOD: The rat model of hyperlipidemia was established by providing high-fat-diet (HFD) for 4 weeks...
December 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29228785/an-overview-on-indications-and-chemical-composition-of-aromatic-waters-hydrosols-as-functional-beverages-in-persian-nutrition-culture-and-folk-medicine-for-hyperlipidemia-and-cardiovascular-conditions
#6
Azadeh Hamedi, Seyed Mahmoud Moheimani, Amirhossein Sakhteman, Hamed Etemadfard, Mahmoodreza Moein
Hydrosol beverages in Persian nutrition culture and ethnomedicine are the side products of essential oil industry that are used as delicious drinks or safe remedies. To investigate indications and chemical composition of hydrosol beverages for hyperlipidemia and cardiovascular conditions, Fars province was selected as the field of study. Ethnomedical data were gathered by questionnaires. The constituents of hydrosols were extracted with liquid/liquid extraction and analyzed by gas chromatography-mass spectrometry...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29228784/efficacy-of-berberine-alone-and-in-combination-for-the-treatment-of-hyperlipidemia-a-systematic-review
#7
Laura M Koppen, Andrea Whitaker, Audrey Rosene, Robert D Beckett
The objective of this review is to identify, summarize, and evaluate clinical trials of berberine for the treatment of hyperlipidemia and other dyslipidemias. A literature search for randomized, controlled trials of berberine that assessed at least 2 lipid values as endpoints resulted in identification of 12 articles that met criteria. The majority of evaluated articles consistently suggest that berberine has a beneficial effect on low-density lipoprotein (reductions ranging from approximately 20 to 50 mg/dL) and triglycerides (reductions ranging from approximately 25 to 55 mg/dL)...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29227535/antidiabetic-and-lipid-lowering-effects-of-the-polyphenol-extracts-from-the-leaves-of-clausena-lansium-lour-skeels-on-streptozotocin-induced-type-2-diabetic-rats
#8
Fansheng Kong, Zhipeng Su, Xiaoming Guo, Feng Zeng, Yongguang Bi
Clausena lansium (Lour.) Skeels (Wampee) is widely grown in China and considered as a healthy fruit. Its leaves are also considered as traditional herbs. This study analyzed polyphenol compounds in polyphenol extracts of the leaves C. lansium (lour.) Skeels (PEL) and investigated the protective effect of PEL against hyperglycemia and hyperlipidemia in T2DM rats. The result showed that PEL is composed mainly of gallic acid, chlorogenic acid, coffee acid, ferulic acid, and rutin. PEL could obviously relieve some symptoms of T2DM rats, including emaciation, hyperhidrosis, polyphagia, diuresis, liver swelling, kidney, and pancreas hypertrophy, as well as reduce fasting blood glucose...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29226968/study-of-micrornas-targeted-dvl2-on-the-osteoblasts-differentiation-of-rat-bmscs-in-hyperlipidemia-environment
#9
Xin Huang, Duoduo Li, Zhifeng Wang, Zhenfei Huang, Xiaofei Dong, Chuanhua Li, Jing Lan
Dishevelled 2 (Dvl-2), a key mediator of the wnt/β-catenin signaling pathway, plays critical roles in osteoblasts differentiation in hyperlipidemia environment. In our previous study, we observed a strong correlation between increased dvl2 expression and decreased new bone formation around implants in a rat hyperlipidemia implant surgery model. However, transcriptional regulation of Dvl2 by microRNAs in this process remains unknown. In the current study, we searched in online database and identified four significantly up-regulated miRNAs, miR-21-5p, miR-29c-3p, miR-138-5p and miR-351-5p that could potentially regulate Dvl2...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29226871/increased-serum-acylated-ghrelin-levels-in%C3%A2-patients-with-mild-cognitive-impairment
#10
Xi Cao, Min Zhu, Yan He, Wenzheng Chu, Yifeng Du, Heng Du
Ghrelin is a stomach-derived circulating hormone. In addition to its function as an orexigenic stimulant, the role of ghrelin in the consolidation of learning and memory has been implicated in recent years. However, the status of circulating acylated ghrelin (AG, that is, the functional form of ghrelin) in the symptomatic predementia stage of Alzheimer's disease (AD) has rarely been investigated. In the current study, we examined the serum levels of acylated and total ghrelin in 22 patients with mild cognitive impairment (MCI) and 30 cognitively normal controls...
December 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29226100/clinical-food-addiction-is-not-associated-with-development-of-metabolic-complications-in-liver-transplant-recipients
#11
Sammy Saab, Cameron Sikavi, Melissa Jimenez, Matthew Viramontes, Ruby Allen, Youssef Challita, Michelle Mai, Negin Esmailzadeh, Jonathan Grotts, Gina Choi, Francisco Durazo, Mohamed El-Kabany, Steven-Huy Han, Elisa Moreno
Background and Aims: Given the increased risk of post-transplant metabolic syndrome (PTMS; defined by hypertension, diabetes mellitus and hyperlipidemia), we aimed to identify the potential role of food addiction in the development of metabolic complications in the post-liver transplant population. Methods: Inclusion criteria included adult liver transplant recipients followed at our institution between June 2016 and November 2016. Participants were administered a demographic survey as well as the Yale Food Assessment Scale 2...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29224645/global-geographical-variation-in-patient-characteristics-in-percutaneous-coronary-intervention-clinical-trials-a-systematic-review-and-meta-analysis
#12
Eden Liu, Leon Hsueh, Hajwa Kim, Mladen I Vidovich
BACKGROUND: We sought to determine whether there are differences in enrolled patients' risk factors in published percutaneous coronary intervention (PCI) trials between various continents. METHODS: We systematically identified clinical trials evaluating PCI interventions through PubMed. We reviewed 701 studies between 1990 and 2014 from North America (N=135), Europe (N=403), and Asia (N=163), examining the prevalence of cardiovascular risk factors-hypertension (HTN), diabetes mellitus (DM), hyperlipidemia (HL), smoking, sex, and body mass index...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29222858/obesity-lipid-profiles-and-oxidative-stress-in-children-after-liver-transplantation
#13
Piotr Czubkowski, Aldona Wierzbicka, Joanna Pawłowska, Irena Jankowska, Piotr Socha
PURPOSE: In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx)...
December 10, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29221604/effect-of-evolocumab-on-lipoprotein-particles
#14
Peter P Toth, Naveed Sattar, Dirk J Blom, Seth S Martin, Steven R Jones, Maria Laura Monsalvo, Mary Elliott, Mike Davis, Ransi Somaratne, David Preiss
The level of low-density lipoprotein cholesterol (LDL-C) reflects the cholesterol carried mainly by low-density lipoprotein particles (LDL-P). LDL-C, however, does not always correlate with LDL-P because of the variable amounts of cholesterol per particle. Consideration of LDL-P concentrations in addition to LDL-C may help guide therapeutic decisions in a select number of patients. Evolocumab is a fully human monoclonal antibody directed against proprotein convertase subtilisin-kexin type 9 that lowers both LDL-C and cardiovascular events...
November 8, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29217178/factors-associated-with-advanced-cardiac-care-in-prehospital-chest-pain-patients
#15
Adam Frisch, Kenneth J Heidle, Stephanie O Frisch, Ashar Ata, Brandon Kramer, Caroline Colleran, Jestin N Carlson
INTRODUCTION: Many patients transported by emergency medical services (EMS) may require advanced cardiac care but do not have ST-segment elevation (STEMI) on the initial prehospital EKG. We sought to identify factors associated with the need for advanced cardiac care in undifferentiated EMS patients reporting chest pain in the absence of STEMI on EKG. METHODS: We performed a retrospective analysis of all adult patients, reporting atraumatic chest pain from a single EMS agency, presenting to a single, urban hospital over a 10-year period...
December 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29214713/stent-graft-treatment-for-infra-inguinal-arterial-disease-for-either-instent-restenosis-and-denovo-lesions-associated-with-very-high-rates-of-failure
#16
Maheswara S Golla, Subasit Acharji, Timir K Paul, Praveena Madapathi, Lawrence A Garcia
BACKGROUND: FDA approved the Gore Viabahn (WL Gore, Flagstaff, AZ, USA) stent for both femoro-popliteal arterial denovo and instent restenosis (ISRS) lesions. To date there is little data on Viabahn stent graft outcomes in ISRS arterial disease. METHODS: Between 2007 and 2014 we identified 734 patients who underwent 1573 endovascular interventions in our institution for infra-inguinal revascularization. Among these, 48 patients had 143 Viabahn stents placed. Of these, 26 patients had 94 stents placed for ISRS and 22 patients had 49 stents placed for denovo lesions...
December 7, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29210652/inhibition-of-jak2-signaling-alleviates-hyperlipidemia-intensified-caerulin-induced-acute-pancreatitis-in-vivo
#17
F Zhu, Y Guan, R Zhang
RATIONALE: Studies have implied the positive association of JAK2/STAT3 signaling with the onset and severity of acute pancreatitis (AP). However, definitive functional study of JAK2/STAT3 signaling in the pathogenesis of acute pancreatitis in vivo is missing and its potential as a therapeutic target and the underlying mechanisms remain to be determined. OBJECTIVES: The aim of this study was to explore the role of JAK2/STAT3 signaling in the pathogenesis of hyperlipidemia-intensified caerulin-induced AP and its potential as a therapeutic target...
December 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29210166/phytoceuticals-in-fenugreek-ameliorate-vldl-overproduction-and-insulin-resistance-via-the-insig-signaling-pathway
#18
Rituraj Khound, Jing Shen, Yongyan Song, Dipak Santra, Qiaozhu Su
SCOPE: This study aimed to characterize the effect of fenugreek (Trigonella foenum-graecum) seed and its phytoceutical trigonelline in anti-metabolic inflammation and ameliorating overproduction of very low density lipoprotein (VLDL) in insulin resistance. METHODS AND RESULTS: Two groups of genetic hyperlipidemic mice generated by depletion of cAMP responsive binding protein H (CREBH) were fed either a chow containing 2% fenugreek seed or vehicle for 7 weeks. Q-RT-PCR and immunoblotting analysis demonstrated that fenugreek seed containing diet inhibited hepatic SREBP-1c activation and the subsequent de novo lipogenesis by enhancing expression of insulin-inducible gene-1 (Insig-1) and gene-2 (Insig-2)...
December 6, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29210009/influence-of-comorbidities-on-the-implementation-of-the-fundus-examination-in-patients-with-newly-diagnosed-type-2-diabetes
#19
Taichi Kawamura, Izumi Sato, Hiroshi Tamura, Yoko M Nakao, Koji Kawakami
AIMS: To investigate the influence of comorbidities on undergoing a diabetic eye examination in patients with newly diagnosed type 2 diabetes mellitus (T2DM). DESIGN: Retrospective cohort study METHODS: This was a retrospective cohort study using data from health insurance claims made between January 2005 and March 2013 in Japan. The primary outcome was implementation of the fundus examination that includes fundus photography, ophthalmoscopy and optical coherence tomography by a doctor within one year of initial drug therapy for Type2 Diabetes Mellitus (T2DM)...
December 5, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208999/associations-between-childhood-body-size-and-seventeen-adverse-outcomes-analysis-of-65-057-european-women
#20
Jingmei Li, Mikael Eriksson, Wei He, Per Hall, Kamila Czene
Large childhood body size has been consistently shown to be associated with decreased breast cancer risk. However, it is important to consider the effects of a large childhood body size on other adult diseases. It is not clear if the associations between childhood body size and adult diseases will persist if they later attain healthy weight. The associations between body size at age 7 and 17 adverse outcomes in adulthood were examined using Cox models in a Swedish study of 65,057 women. Large body size at age 7, when compared to small body size, was associated with decreased risk for breast cancer (HR [95% CI]: 0...
December 5, 2017: Scientific Reports
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