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Hossein Golmoghaddam, Shirin Farjadian, Shahdad Khosropanah, Pooyan Dehghani, Mehrnoosh Doroudchi
BACKGROUND: Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of the disease through presentation of self or foreign antigens to T cells. OBJECTIVE: To investigate the association of HLA-DRB1 alleles with atherosclerosis in a sample of southwestern Iranians...
September 2018: Iranian Journal of Immunology: IJI
Piao Shenghua, Tan Shuyu, Li Kunping, Zhan Huixia, Xiao Xue, Guo Jiao
Hyperlipidemia is a common disease caused by abnormal plasma lipid metabolism. Lipidomics is a powerful and efficient technology to study the integration of disease and syndrome of Chinese medicine. This study investigated specific changes in lipid metabolites from hyperlipidemia patients with syndrome of liver qi-stagnation and spleen-deficiency (SLQSD). Lipid profiles in plasma samples from 29 hyperlipidemia patients including 10 SLQSD and 19 non-SLQSD and 26 healthy volunteers (NC) were tested by UPLC-QTOF/MS...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Eun-Jung Lee, Hyeongjoo Oh, Beom Goo Kang, Min-Kyung Kang, Dong Yeon Kim, Yun-Ho Kim, Jeong Yeol Lee, Joung Gun Ji, Soon Sung Lim, Young-Hee Kang
Coconut oil has gained in popularity over recent years as healthy oil due to its potential cardiovascular benefits. Coconut oil contains medium chain triglycerides (MCT) including lauric acid and capric acid that display beneficial properties in human health. Licorice (Glycyrrhiza uralensis) is used as a sweetener and in traditional Chinese medicine with anti-inflammatory, anti-microbial and antioxidant activities. This study investigated the in vivo effects of medium chain-triglycerides (MCT)-coconut oil (MCO) and its combination with licorice extract (LE-MCO) on serum lipid profile, hepatic steatosis, and local fat pad proteins in diet-induced obese mice...
September 24, 2018: Journal of Agricultural and Food Chemistry
Rui Lu, Tingting Yuan, Yingge Wang, Ting Zhang, Yuguo Yuan, Daijin Wu, Minya Zhou, Zhengyi He, Yaoyao Lu, Yajie Chen, Jianglin Fan, Jingyan Liang, Yong Cheng
Rabbits (Oryctolagus cuniculus) have been the very frequently used as animal models in the study of human lipid metabolism and atherosclerosis, because they have similar lipoprotein metabolism to humans. Most of hyperlipidemia and atherosclerosis rabbit models are produced by feeding rabbits a high-cholesterol diet. Gene editing or knockout (KO) offered another means of producing rabbit models for study of the metabolism of lipids and lipoproteins. Even so, apolipoprotein (Apo)E KO rabbits must be fed a high-cholesterol diet to induce hyperlipidemia...
September 19, 2018: EBioMedicine
Syuan-Hao Syu, Yung-Wei Lin, Ke-Hsun Lin, Liang-Ming Lee, Chi-Hao Hsiao, Yu-Ching Wen
Immunosuppressive therapies decreased the incidence of acute kidney rejection after kidney transplantation, but also increased the risk of infections and sepsis. This study aimed to identify the risk factors associated with complications and/or graft failure in kidney transplant patients with sepsis. A total of 14,658 kidney transplant patients with sepsis, identified in the National Inpatient Sample (NIS) database (data from 2005-2014), were included in the study and classified into three groups: patients without complications or graft failure/dialysis (Group 1), patients with complications only (Group 2), and patients with complications and graft failure/dialysis (Group 3)...
September 16, 2018: Bosnian Journal of Basic Medical Sciences
Sung-Chun Tang, Kai-Chien Yang, Chih-Hao Chen, Shieh-Yueh Yang, Ming-Jang Chiu, Chau-Chung Wu, Jiann-Shing Jeng
Increases in plasma of β-amyloids (Aβ) and tau proteins have been noted in patients with Alzheimer's dementia (AD). Our study investigated the associations of plasma Aβ and tau proteins with dementia in stroke patients. This cross-sectional study recruited 24 controls (mean age: 67.4 ± 7.5 years, 33.3% male), 27 stroke patients without dementia (mean age: 70.7 ± 6.9 years, 60.7% male), 34 stroke patients with dementia (mean age: 78.3 ± 5.3 years, 45.5% male, Clinical Dementia Ranking (CDR): 1...
September 21, 2018: Neuromolecular Medicine
Sergio Susmallian, Royi Barnea, Yossi Weiss, Asnat Raziel
BACKGROUND: People are living longer than they were expected to 2 decades ago. Increased life expectancy and reduced mortality encompasses a simultaneous increase in the number of older adults with obesity that entails an increase of co-morbidities, such as diabetes, hypertension, cancer, and many other diseases. The aim of our study was to compare the outcomes of bariatric surgery in patients age ≥65 in comparison with younger patients. METHODS: This retrospective study compares bariatric surgeries performed in a private institution between the years 2013 and 2015...
August 11, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Shan Li, Junhui Li, Guizhu Mao, Yaqin Hu, Xingqian Ye, Ding Tian, Robert J Linhardt, Shiguo Chen
Fucosylated chondroitin sulfate (fCS) and its depolymerized derivative (DfCS), prepared from sea cucumbers, are well-known for their anticoagulant activity. However, their other functional activities are poorly understood. Recently, we obtained fCS oligosaccharides from Isostichopus Badionotus by a modified controllable Fenton-system, named as DfCS-Ib. The functional activities of these oligosaccharides are still unclear. The present study investigated anti-hyperlipidemic activity of DfCS-Ib using a high-fat diet (HFD)-fed mice model...
December 1, 2018: Carbohydrate Polymers
He Gao, Jia-Jia Wen, Jie-Lun Hu, Qi-Xing Nie, Hai-Hong Chen, Tao Xiong, Shao-Ping Nie, Ming-Yong Xie
The influence of Lactobacillus plantarum-fermentation on the structure and anti-diabetic effects of Momordica charantia polysaccharides were evaluated. High-fat diet and streptozotocin-induced type 2 diabetic rats were administrated with polysaccharides from fermented and non-fermented Momordica charantia (FP and NFP) for 4 weeks. Fermentation affected the physicochemical characterization, monosaccharide composition, molecular weight, and viscosity of Momordica charantia polysaccharides. Treatment with FP significantly ameliorated hyperglycemia, hyperinsulinemia, hyperlipidemia, and oxidative stress in diabetic rats compared with NFP...
December 1, 2018: Carbohydrate Polymers
Jing Qiao, Yuying Liu, Zhiwen Jiang, Yan Yang, Wanshun Liu, Baoqin Han
Carboxymethyl chitosan oligosaccharide (CMCOS), the hydrolytic product of carboxymethyl chitosan, is nontoxic, easily absorbable and good antioxidant. In this study, CMCOS was prepared and its properties in adriamycin nephropathy therapy were investigated. Our results showed that CMCOS had good curative effects on renal function and parenchymal injury induced by adriamycin. CMCOS administration significantly relieved symptoms of proteinuria, hypoalbuminemia, hyperlipidemia, renal hyperplasia and histological lesions in rats (P < 0...
December 1, 2018: Carbohydrate Polymers
Jun-Cheng Zhuo, Da-Ke Cai, Kai-Feng Xie, Hai-Ning Gan, Sha-Sha Li, Xue-Jun Huang, Dane Huang, Cheng-Zhe Zhang, Ru-Yue Li, Yu-Xing Chen, Xiao-Hui Zeng
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by dysfunction of glycolipid metabolism. YLTZ is used to treat hyperlipidemia, yet its hypolipidemic and hypoglycemic mechanism on T2DM are unknown. Thus, UPLC/TOF/MS was applied in this study to identify the potential bio-markers, and deduce the possible metabolic pathways. According to bio-indexes, the increased blood lipid levels, including TC, TG, LDL and FA, and the decreased HDL, the elevated glucose, reduced insulin level and impaired OGTT were observed in diabetic rat model...
August 24, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Huali Wu, Wenting Lv, Qi Pan, Praveen Kumar Kalavagunta, Qiongzhen Liu, Guohong Qin, Minxuan Cai, Liangliang Zhou, Tao Wang, Zhenjiang Xia, Jing Shang
BACKGROUND: A high-fat diet (HFD)-induced obesity/hyperlipidemia is accompanied by hormonal and neurochemical changes that can be associated with depression. Emerging studies indicate that simvastatin (SMV, decreasing cholesterol levels) has therapeutic effects on neurological and neuropsychiatric diseases through hippocampal-dependent function. However, the studies on the HFD exposure in adolescent animals, which investigate the neuroprotective effects of SMV on the hippocampal morphology, serotonin (5-HT) system and inflammation, are limited...
September 11, 2018: Journal of Affective Disorders
Seunghoon Lee, Hyeonhoon Lee, Yeeun Cho, Jihye Kim, Jung Won Kang, Byung-Kwan Seo, Yong-Hyeon Baek, Jae-Dong Lee
BACKGROUND: This study aims to evaluate the efficacy, safety, and appropriate dose of Hanslim, a Korean traditional herbal medicine, for obese patients, when compared to a placebo. METHODS/DESIGN: This study is a randomized, double-blinded, multicenter, multidose, placebo-controlled, phase IIb clinical trial. A total of 165 obese patients with a body mass index (BMI) of more than 30 kg/m or obese patients with a BMI of 27 to 29.9 kg/m and one or more risk factors such as hypertension, diabetes, or hyperlipidemia will be enrolled...
September 2018: Medicine (Baltimore)
Helen H L Chan, Thomas G Hardy, Alan A McNab
PURPOSE: The authors present the largest series of patients to date of spontaneous hemorrhage in relation to extraocular muscles (EOMs). METHODS: Observational retrospective case series. Institutional review board approval was obtained. RESULTS: Eighteen patients with a mean age of 71 years presented with 20 episodes of spontaneous orbital hemorrhage closely related to an EOM. Most patients woke with unilateral proptosis, pain, and diplopia...
September 18, 2018: Ophthalmic Plastic and Reconstructive Surgery
Rory A Guenther, Walter L Kemp
While the characteristic features of nephrotic syndrome (ie, proteinuria, hypoalbuminemia, peripheral edema, and hyperlipidemia) are well known, the association of nephrotic syndrome and the risk of thromboembolic events is not as often appreciated and may be overlooked. This report describes a 10-year-old boy with focal segmental glomerulosclerosis who died following a saddle pulmonary thromboembolus, with near-complete occlusion of the left and right pulmonary arteries. The gross appearance of the thrombus suggested organization and histologic changes within the wall of the pulmonary artery indicated a period of at least 3 or more hours to a few days since the event occurred...
September 17, 2018: American Journal of Forensic Medicine and Pathology
Fuu-Jen Tsai, Mao-Wang Ho, Chih-Ho Lai, Chen-Hsing Chou, Ju-Pi Li, Chi-Fung Cheng, Yang-Chang Wu, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Jung-Chun Lin, Chih-Chien Lin, Ching-Liang Hsieh, Wen-Miin Liang, Ying-Ju Lin
Antiretroviral (ART) drugs has previously been associated with lipodystrophic syndrome, metabolic consequences, and neuropsychiatric complications. ART drugs include three main classes of protease inhibitors (PIs), nucleoside analog reverse transcriptase inhibitors (NRTIs), and non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our previous work demonstrated that a high risk of hyperlipidemia was observed in HIV-1-infected patients who received ART drugs in Taiwan. Patients receiving ART drugs containing either Abacavir/Lamivudine (Aba/Lam; NRTI/NRTI), Lamivudine/Zidovudine (Lam/Zido; NRTI/NRTI), or Lopinavir/Ritonavir (Lop/Rit; PI) have the highest risk of hyperlipidemia...
2018: Frontiers in Pharmacology
Anne H Blaes, Paaladinesh Thavendiranathan, Javid Moslehi
Cancer therapies can cause a variety of cardiac toxicities, including ischemia, cardiomyopathy, heart failure, myocarditis, arrhythmias, vascular disease, hypertension, and hyperlipidemia. Addressing cardiovascular risk at baseline, before initiating therapy, during cancer treatment, and in the survivorship period is imperative. It may be useful to risk stratify individuals with cardiovascular risk factors using biomarkers or imaging before they receive potentially cardiotoxic therapies. Additionally, new guidelines recommend cardiac imaging with echocardiography in the survivorship period 6 to 12 months after completing cancer therapy for these high-risk individuals...
May 23, 2018: American Society of Clinical Oncology Educational Book
Manuel E Minas da Piedade, Ricardo G Simoes, Carlos E S Bernardes, Abhinav Joseph, M Fátima M da Piedade, Werner Kraus, Franziska Emmerling, Herminio P Diogo
Simvastatin is one of the most widely used active pharmaceutical ingredients for the treatment of hyperlipidemias. Because the compound is employed as a solid in drug formulations, particular attention should be given to the characterization of different polymorphs, their stability domains and the nature of the phase transitions that relate them. In this work the phase transitions delimiting the stability domains of three previously reported simvastatin forms were investigated from structural, energetics, and dynamical points of view, based on single crystal X-ray diffraction (SCXRD), hot stage microscopy (HSM) and differential scanning calorimetry (DSC) experiments (conventional scans and heat capacity measurements), complemented with molecular dynamics (MD) simulations...
September 19, 2018: Molecular Pharmaceutics
Salahdein Aburuz, Abdulkareem Al-Bekairy, Abdul-Aziz Alqahtani, Khalid Harbi, Mohammed Al Nuhait, Abdullah Khoja, Adel Sadeq, Mohammed Al Rashed
Background: One of the major risk factors for cardiovascular diseases is hyperlipidemia. The primary aim of this study was to estimate the proportion of individuals between 40-75 years old that would be eligible for statin therapy based on ACC/AHA guideline as compared to ATP-III guideline in a population of patients in Saudi Arabia. We also intended to extrapolate the results to the entire Saudi population, and estimate the cost implications of the ACC/AHA treatment guideline. Methods: This study was a retrospective, observational study involving adult patients aged between 40-75 years old...
October 2018: Journal of the Saudi Heart Association
Daniel N Velasco Hernández, Santiago B De Battista, Héctor R Horiuchi, Maria M Zicavo
INTRODUCTION: Although carcinoid tumours are a rare gastrointestinal neoplasm with an incidence rate of 1-2.5 cases per 100 000 inhabitants, they are the most common neuroendocrine tumour of the stomach. PRESENTATION OF CASE: A 70-year-old-man consulted for epigastric pain and dyspepsia symptoms. His past medical and surgical history included obesity (BMI: 53.9 kg/m2 ), hypertension, hyperlipidemia, diabetes mellitus type 2, cardiac failure and a surgical treatment with laparoscopic gastric banding...
September 4, 2018: International Journal of Surgery Case Reports
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