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https://www.readbyqxmd.com/read/28087447/structures-biological-activities-and-industrial-applications-of-the-polysaccharides-from-hericium-erinaceus-lion-s-mane-mushroom-a-review
#1
REVIEW
Xirui He, Xiaoxiao Wang, Jiacheng Fang, Yu Chang, Ning Ning, Hao Guo, Linhong Huang, Xiaoqiang Huang, Zefeng Zhao
Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging...
January 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28087295/postconditioning-induced-neuroprotection-mechanisms-and-applications-in-cerebral-ischemia
#2
REVIEW
Yan-Ying Fan, Wei-Wei Hu, Fang Nan, Zhong Chen
Ischemic postconditioning (PostC) is defined as a series of rapid intermittent interruptions of blood flow at the phase of reperfusion, which produces neuroprotection against cerebral ischemia/reperfusion injury via mobilizing the brain's own endogenous adaptive mechanisms. Now the concept of conventional ischemic PostC has been extended to limb remote ischemic PostC and chemical PostC with hypoxia, volatile anesthetic, CO2, etc. According to the different temporal profile of PostC, it is divided into rapid and delayed PostC...
January 10, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28084704/hyperlipidemia-drugs-for-cardiovascular-risk-reduction-in-adults
#3
Allen R Last, Jonathan D Ference, Elizabeth Rollmann Menzel
Guidelines from the American College of Cardiology/American Heart Association (ACC/AHA) and the U.K. National Institute for Health and Care Excellence (NICE) indicate that lipid-lowering drugs have benefit for primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) events. The evidence is strongest for statins. ACC/AHA, NICE, and U.S. Preventive Services Task Force (USPSTF) guidelines recommend statin therapy based on patients' risk of an ASCVD event, rather than treating to specific lipid levels...
January 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28084058/the-selective-ppar%C3%AE-modulator-k-877-efficiently-activates-the-ppar%C3%AE-pathway-and-improves-lipid-metabolism-in-mice
#4
Kenta Takei, Song-Iee Han, Yuki Murayama, Aoi Satoh, Fusaka Oikawa, Hiroshi Ohno, Yoshinori Osaki, Takashi Matsuzaka, Motohiro Sekiya, Hitoshi Iwasaki, Shigeru Yatoh, Naoya Yahagi, Hiroaki Suzuki, Nobuhiro Yamada, Yoshimi Nakagawa, Hitoshi Shimano
AIMS/INTRODUCTION: Peroxisome proliferator-activated receptor α (PPARα) is a therapeutic target for hyperlipidemia. K-877 is a new selective PPARα modulator (SPPARMα) that activates PPARα transcriptional activity. The aim of the present study was to assess the effects of K-877 on lipid metabolism in vitro and in vivo compared with those of classical PPARα agonists. MATERIALS AND METHODS: To compare the effects of K-877 on PPARα transcriptional activity with those of the classical PPARα agonists Wy14643 (Wy) and fenofibrate (Feno), the cell-based PPARα transactivation luciferase assay was performed...
January 13, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28081181/aronia-melanocarpa-extract-ameliorates-hepatic-lipid-metabolism-through-ppar%C3%AE-2-downregulation
#5
Chung-Hwa Park, Jung-Hee Kim, Eun Byul Lee, Wonhee Hur, Oh-Joo Kwon, Hyoung-Jin Park, Seung Kew Yoon
Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Studies have demonstrated that anthocyanin-rich foods may improve hyperlipidemia and ameliorate hepatic steatosis. Here, effects of Aronia melanocarpa (AM), known to be rich of anthocyanins, on hepatic lipid metabolism and adipogenic genes were determined. AM was treated to C57BL/6N mice fed with high fat diet (HFD) or to FL83B cells treated with free fatty acid (FFA). Changes in levels of lipids, enzymes and hormones were observed, and expressions of adipogenic genes involved in hepatic lipid metabolism were detected by PCR, Western blotting and luciferase assay...
2017: PloS One
https://www.readbyqxmd.com/read/28078642/association-between-subtotal-gastrectomy-with-billroth-ii-anastomosis-and-coronary-heart-disease
#6
Chien-Hua Chen, Cheng-Li Lin, Yu-Shu Cheng, Long-Bin Jeng
BACKGROUND: We assessed the risk of coronary heart disease (CHD) after subtotal gastrectomy with Billroth II anastomosis (SGBIIA) for peptic ulcer disease (PUD). METHODS: The Taiwan National Health Insurance Research Database was used, and 6160 patients undergoing SGBIIA for PUD were identified as the surgical cohort. A total of 24,540 patients from the PUD population not undergoing surgery selected by frequency-matching were identified as the non-surgical cohort...
January 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28074822/pleiotropic-effects-of-statins-in-the-perioperative-setting
#7
REVIEW
George Galyfos, Argyri Sianou, Konstantinos Filis
Statins belong to a specific group of drugs that have been described for their ability to control hyperlipidemia as well as for other pleiotropic effects such as improving vascular endothelial function, inhibition of oxidative stress pathways, and anti-inflammatory actions. Accumulating clinical evidence strongly suggests that statins also have a beneficial effect on perioperative morbidity and mortality. Therefore, this review aims to present all recent and pooled data on statin treatment in the perioperative setting as well as to highlight considerations regarding their indications and therapeutic application...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28074044/diabetic-myonecrosis-a-rare-complication-of-diabetes-mellitus-mimicking-deep-vein-thrombosis
#8
Himanshu K Khanna, Andrew C Stevens
BACKGROUND Diabetic myonecrosis is an uncommon complication of long-standing poorly controlled diabetes mellitus. It presents as acute non-traumatic swelling and pain of the lower extremity, which can mimic deep vein thrombosis (DVT). The clinical course is usually self-limiting and patients respond well to supportive medical therapy. CASE REPORT A 54-year-old male with past medical history of poorly controlled diabetes mellitus type II, hyperlipidemia, gastroesophageal reflux disease (GERD), and remote history of DVT presented to our emergency department with 2-week history of progressively worsening left calf pain and swelling...
January 11, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28073830/adiponectin-deficiency-impairs-maternal-metabolic-adaptation-to-pregnancy-in-mice
#9
Liping Qiao, Jean-Sebastien Wattez, Samuel Lee, Amanda Nguyen, Jerome Schaack, William W Hay, Jianhua Shao
Hypoadiponectinemia has been widely observed in patients with gestational diabetes. To investigate the causal role of hypoadiponectinemia in gestational diabetes, adiponectin gene knockout (Adipoq(-/-)) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. Adenoviral vector-mediated in vivo transduction was used to reconstitute adiponectin during late pregnancy. Results showed that Adipoq(-/-) dams developed glucose intolerance and hyperlipidemia in late pregnancy...
January 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28072731/focal-segmental-glomerulosclerosis-lagged-behind-the-onset-of-rheumatoid-arthritis-by-7-years-a-case-report-and-literature-review
#10
Yang Liu, Hong-Yan Wen, Li-Hua Wang, Chen Wang
INTRODUCTION: The co-existence of focal segmental glomerulosclerosis (FSGS) and rheumatoid arthritis (RA), presenting either together or in succession, is very rare. A variety of histopathological features in the clinical renal disease may occur in RA. Only 8 studies have previously reported this poorly understood connection. CLINICAL FINDINGS/DIAGNOSES: A case of a 54-year-old male with RA lasting for more than 7 years developed cheirarthritis as the first signs...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070236/interaction-of-hyperlipidemia-and-reactive-oxygen-species-insights-from-the-lipid-raft-platform
#11
EDITORIAL
Eisuke Amiya
Reactive oxygen species (ROS) and oxidative stress are closely associated with the development of atherosclerosis, and the most important regulator of ROS production in endothelial cells is NADPH oxidase. Activation of NADPH oxidase requires the assembly of multiple subunits into lipid rafts, which include specific lipid components, including free cholesterol and specific proteins. Disorders of lipid metabolism such as hyperlipidemia affect the cellular lipid components included in rafts, resulting in modification of cellular reactions that produce ROS...
December 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/28070102/altered-susceptibility-of-an-obese-rat-model-to-13-week-subchronic-toxicity-induced-by-3-monochloropropane-1-2-diol
#12
Takeshi Toyoda, Young-Man Cho, Jun-Ichi Akagi, Yasuko Mizuta, Kohei Matsushita, Akiyoshi Nishikawa, Katsumi Imaida, Kumiko Ogawa
3-Monochloropropane-1,2-diol (3-MCPD) is a heat-induced food contaminant that has been shown to be a nongenotoxic renal carcinogen. Although the toxicity of 3-MCPD has been widely investigated for decades, there is a further concern that 3-MCPD might exert more potent toxicity in high-risk population with underlying diseases such as hyperlipidemia associated with obesity. In the present study, we performed a 13-week subchronic toxicity study for 3-MCPD using an obesity rat model to investigate the differences in susceptibility between obese and normal individuals...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28069327/early-ventricular-tachyarrhythmias-after-coronary-artery-bypass-grafting-surgery-is-it-a-real-burden
#13
Elisabeth M J P Mouws, Ameeta Yaksh, Paul Knops, Charles Kik, Eric Boersma, Ad J J C Bogers, Natasja M S de Groot
BACKGROUND: The prevalence of ventricular dysrhythmias (VD) [ventricular premature beats (VPBs), ventricular couplets (Vcouplets), ventricular runs (Vruns)] after coronary artery bypass grafting (CABG) has so far not been examined. The goal of this study is to examine characteristics of VD and whether they precede ventricular tachyarrhythmias (VTA) during a postoperative follow-up period of 5 days using continuous rhythm registrations. In addition, we determined predictive factors of VD/VTA...
January 6, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28069019/ppars-modulate-cardiac-metabolism-and-mitochondrial-function-in-diabetes
#14
REVIEW
Ting-Wei Lee, Kuan-Jen Bai, Ting-I Lee, Tze-Fan Chao, Yu-Hsun Kao, Yi-Jen Chen
Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently, effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic cardiomyopathy is complex, whereas mitochondrial dysfunction plays a vital role in the genesis of diabetic cardiomyopathy. Metabolic regulation targeting mitochondrial dysfunction is expected to be a reasonable strategy for treating diabetic cardiomyopathy. Peroxisome proliferator-activated receptors (PPARs) are master executors in regulating glucose and lipid homeostasis and also modulate mitochondrial function...
January 10, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28066010/olanzapine-has-better-efficacy-compared-to-risperidone-for-treatment-of-negative-symptoms-in-schizophrenia
#15
P N Suresh Kumar, P K Anish, V Rajmohan
OBJECTIVE: The safety and efficacy profile of risperidone and olanzapine were compared in a double-blind trial that used doses widely accepted in clinical practice. METHODS: Subjects (n = 71) who met Diagnostic and Statistical Manual of Mental Disorders-IV criteria for schizophrenia were randomly assigned to receive 2-8 mg/day of risperidone (mean modal dose = 5.5 mg/day) or 5-20 mg/day of olanzapine (mean modal dose = 14.4 mg/day) for 1 year. RESULTS: The two study groups were similar at baseline in all aspects...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28065772/multimorbidity-in-middle-aged-adults-with-cerebral-palsy
#16
Nicole Cremer, Edward A Hurvitz, Mark D Peterson
BACKGROUND: Individuals with cerebral palsy have less lean body mass, greater relative adiposity, and lower fitness and physical activity participation; and yet, the prevalence of age-related multimorbidity in this population has yet to be established. PURPOSE: To examine the prevalence of lifestyle-related chronic conditions and multimorbidity in a sample of middle-aged adults with cerebral palsy. METHODS: A clinic-based sample of middle-aged adults with cerebral palsy was examined using Electronic Medical Records Search Engine (EMERSE) software...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28063380/hydroxytyrosol-supplementation-increases-vitamin-c-levels-in-vivo-a-human-volunteer-trial
#17
Eduardo Lopez-Huertas, Juristo Fonolla
Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular disease risk, enzyme markers of several clinical conditions, hematology, antioxidant parameters, vitamins and minerals at baseline (T0), 4 weeks (T4) and 8 weeks (T8). The values obtained at T4 and T8 were compared with baseline...
December 26, 2016: Redox Biology
https://www.readbyqxmd.com/read/28062721/vascular-risk-factors-in-inph-a-prospective-case-control-study-the-inph-crash-study
#18
Hanna Israelsson, Bo Carlberg, Carsten Wikkelsö, Katarina Laurell, Babar Kahlon, Göran Leijon, Anders Eklund, Jan Malm
OBJECTIVE: To assess the complete vascular risk factor (VRF) profile of idiopathic normal pressure hydrocephalus (INPH) using a large sample of representative patients with INPH and population-based controls to determine the extent to which vascular disease influences INPH pathophysiology. METHODS: All patients with INPH who underwent shunting in Sweden in 2008-2010 were compared to age- and sex-matched population-based controls. Inclusion criteria were age 60-85 years and no dementia...
January 6, 2017: Neurology
https://www.readbyqxmd.com/read/28061763/trend-in-young-coronary-artery-disease-in-china-from-2010-to-2014-a-retrospective-study-of-young-patients%C3%A2-%C3%A2-%C3%A2-45
#19
Xin Wang, Ming Gao, Shanshan Zhou, Jinwen Wang, Fang Liu, Feng Tian, Jing Jin, Qiang Ma, Xiaodi Xue, Jie Liu, Yuqi Liu, Yundai Chen
BACKGROUND: The incidence of young coronary heart disease (CHD, ≤45 years) in China is increasing. Secondary prevention to counter this trend is an important contemporary public health issure. METHODS: A total of 5288 patients (≤45 years) diagnosed with CHD and hospitalized at the Chinese PLA General Hospital and Anzhen Hospital, both in Beijing, were enrolled after satisfying the inclusion criteria. RESULTS: Young CHD patients increased in number from 2010 to 2014, especially men...
January 7, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28060916/nocturia-is-associated-with-slipping-and-falling
#20
So Young Kim, Woojin Bang, Min-Su Kim, Bumjung Park, Jin-Hwan Kim, Hyo Geun Choi
Several reports have demonstrated associations between falls and nocturia in the elderly. However, little information is available regarding other age groups. This study evaluated the relationship between the frequency of nocturia and falls in men using a large, population-based survey in Korea, and the results were adjusted for various confounding factors. Data from a 2011 Korean community health survey (KCHS) were retrieved for 92,660 men aged 19 to 103 years. Information regarding the history of slips or falls in the past year was collected...
2017: PloS One
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