Katrien Forier, Virginie Van Heck, Mieke Carlier, Eva Van Braeckel, Sabine Van Daele, Frans De Baets, Petra Schelstraete, Filomeen Haerynck, Veronique Stove, Leen Van Simaey, Mario Vaneechoutte, Alain G Verstraete
Objectives: Antibiotic therapy is of vital importance for the control of infectious exacerbations in cystic fibrosis (CF) patients. However, very little is known regarding the fraction of systemically administered antibiotics reaching the lower respiratory tract secretions. We developed and validated a method to measure the concentrations of piperacillin, ceftazidime, meropenem and aztreonam in CF sputum, and present the validation data. Methods: Ultra-performance LC coupled to tandem MS was used...
January 1, 2018: Journal of Antimicrobial Chemotherapy