Rosa Bellavita, Elisabetta Buommino, Bruno Casciaro, Francesco Merlino, Floriana Cappiello, Noemi Marigliano, Anella Saviano, Francesco Maione, Rosaria Santangelo, Maria Luisa Mangoni, Stefania Galdiero, Paolo Grieco, Annarita Falanga
Temporin family is one of the largest among antimicrobial peptides (AMPs), which act mainly by penetrating and disrupting the bacterial membranes. To further understand the relationship between the physical-chemical properties and their antimicrobial activity and selectivity, an analogue of Temporin L, [Nle1 , dLeu9 , dLys10 ]TL (Nle-Phe-Val-Pro-Trp-Phe-Lys-Phe-dLeu-dLys-Arg-Ile-Leu-CONH2 ) has been developed in the present work. The design strategy consisted of the addition of a norleucine residue at the N-terminus of the lead peptide sequence, [dLeu9 , dLys10 ]TL, previously developed by our group...
September 21, 2022: Antibiotics