Medjda Bellamri, Lihua Yao, Rachana Tomar, Vladimir Vartanian, Carmelo J Rizzo, Michael P Stone, John D Groopman, R Stephen Lloyd, Robert J Turesky
Aflatoxin B1 (AFB1 ) is a potent human liver carcinogen produced by certain molds, particularly Aspergillus flavus and Aspergillus parasiticus , which contaminate peanuts, corn, rice, cottonseed, and ground and tree nuts, principally in warm and humid climates. AFB1 undergoes bioactivation in the liver to produce AFB1 - exo -8,9-epoxide, which forms the covalently bound cationic AFB1 - N 7-guanine (AFB1 -N 7-Gua) DNA adduct. This adduct is unstable and undergoes base-catalyzed opening of the guanine imidazolium ring to form two ring-opened diastereomeric 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy-aflatoxin B1 (AFB1 -FapyGua) adducts...
March 18, 2024: Chemical Research in Toxicology