keyword
https://read.qxmd.com/read/38534591/influence-of-lowering-the-ph-value-on-the-generation-of-fibrous-structures-of-protein-gels-with-different-network-types
#1
JOURNAL ARTICLE
Felix Ellwanger, Melanie Fuhrmann, Heike P Karbstein, Gabriela Itziar Saavedra Isusi
High-moisture extrusion of plant proteins to create meat-like structures is a process that has met with increasing attention in the recent past. In the process, the proteins are thermomechanically stressed in the screw section of the extruder, and the resulting protein gel is structured in the attached cooling die. Various protein sources, notably soy protein isolate (SPI) and wheat gluten, are used to form gels with different networks: SPI creates a physical, non-covalent network, while gluten forms a chemical, covalent one...
February 29, 2024: Gels
https://read.qxmd.com/read/38534575/disulfide-cross-linked-polymeric-redox-responsive-nanocarrier-based-on-heparin-chitosan-and-lipoic-acid-improved-drug-accumulation-increased-cytotoxicity-and-selectivity-to-leukemia-cells-by-tumor-targeting-via-aikido-principle
#2
JOURNAL ARTICLE
Igor D Zlotnikov, Alexander A Ezhov, Natalia V Dobryakova, Elena V Kudryashova
We have developed a micellar formulation of anticancer drugs based on chitosan and heparin grafted with lipoic and oleic acids that can release the cytotoxic cargo (doxorubicin) in response to external stimuli, such as increased glutathione concentration-a hallmark of cancer. Natural polysaccharides (heparin and chitosan) provide the pH sensitivity of the nanocarrier: the release of doxorubicin (Dox) is enhanced in a slightly acidic environment (tumor microenvironment). Fatty acid residues are necessary for the formation of nanoparticles (micelles) and solubilization of cytostatics in a hydrophobic core...
February 20, 2024: Gels
https://read.qxmd.com/read/38534029/cascade-catalyzed-nanogel-for-amplifying-starvation-therapy-by-nitric-oxide-mediated-hypoxia-alleviation
#3
JOURNAL ARTICLE
Wei Wang, Yafan Niu, Ni Zhang, Yuqing Wan, Yiqing Xiao, Lingzhi Zhao, Bingbing Zhao, Wei Chen, Dechun Huang
Glucose oxidase (Gox)-mediated starvation therapy offers a prospective advantage for malignancy treatment by interrupting the glucose supply to neoplastic cells. However, the negative charge of the Gox surface hinders its enrichment in tumor tissues. Furthermore, Gox-mediated starvation therapy infiltrates large amounts of hydrogen peroxide (H2 O2 ) to surround normal tissues and exacerbate intracellular hypoxia. In this study, a cascade-catalyzed nanogel (A-NE) was developed to boost the antitumor effects of starvation therapy by glucose consumption and cascade reactive release of nitric oxide (NO) to relieve hypoxia...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38528795/red-carbon-mediated-formation-of-cu-2-o-clusters-dispersed-on-the-oxocarbon-framework-by-fehling-s-route-and-their-use-for-the-nitrate-electroreduction-in-acidic-conditions
#4
JOURNAL ARTICLE
Jingwen Ba, Hongliang Dong, Mateusz Odziomek, Feili Lai, Rui Wang, Yandong Han, Jinfu Shu, Markus Antonietti, Tianxi Liu, Wensheng Yang, Zhihong Tian
The oligomers of carbon suboxide, known as red carbon, exhibit a highly conjugated structure and semiconducting properties. Upon mild heat treatment, it transforms into a carbonaceous framework rich in oxygen surface terminations, called oxocarbon. In this study, we harness the abundant oxygen functionalities as anchors to create oxocarbon-supported nanohybrid electrocatalysts. Starting with single atomic Cu (II) strongly coordinated to oxygen atoms on red carbon, the Fehling reaction leads to the formation of Cu2 O clusters...
March 25, 2024: Advanced Materials
https://read.qxmd.com/read/38527608/self-signal-electrochemical-identification-of-circulating-tumor-dna-employing-poly-xanthurenic-acid-assembled-on-black-phosphorus-nanosheets
#5
JOURNAL ARTICLE
Xinyu Yan, Wei Zhang, Jimin Yang
A self-signal electrochemical identification interface was prepared for the determination of circulating tumor DNA (ctDNA) in peripheral blood based on poly-xanthurenic acid (PXTA) assembled on black phosphorus nanosheets (BPNSs) acquired through simple ultrasonication method. The BPNSs with large surface area could be integrated with the xanthurenic acid (XTA) monomers by right of physisorption, and hence improved the electropolymerization efficiency and was beneficial to the enlargement of the signal response of PXTA...
March 23, 2024: Analytical Biochemistry
https://read.qxmd.com/read/38525818/naturally-derived-injectable-dual-cross-linked-adhesive-hydrogel-for-acute-hemorrhage-control-and-wound-healing
#6
JOURNAL ARTICLE
Ziran Zhu, Huijun Ye, Kaiwen Zhang, Gang He, Zheng Pan, Yiwen Xian, Yu Yang, Chong Zhang, Decheng Wu
Developing biocompatible injectable hydrogels with high mechanical strength and rapid strong tissue adhesion for hemostatic sealing of uncontrolled bleeding remains a prevailing challenge. Herein, we engineer an injectable and photo-cross-linkable hydrogel based on naturally derived gelatin methacrylate (GelMA) and N -hydroxysuccinimide-modified poly(γ-glutamic acid) (γPGA-NHS). The chemically dual-cross-linked hydrogel rapidly forms after UV light irradiation and covalently bonds to the underlying tissue to provide robust adhesion...
March 25, 2024: Biomacromolecules
https://read.qxmd.com/read/38525500/mechanically-tunable-circularly-polarized-luminescence-of-liquid-crystal-templated-chiral-perovskite-quantum-dots
#7
JOURNAL ARTICLE
Xuan Zhang, Lin Li, Yuanhao Chen, Cristian Valenzuela, Yuan Liu, Yanzhao Yang, Yufan Feng, Ling Wang, Wei Feng
Endowing perovskite quantum dots (PQDs) with circularly polarized luminescence (CPL) offers great promise for innovative chiroptical applications, but the existing strategies are inefficient in acquiring stimuli-responsive flexible chiral perovskite films with large, tunable dissymmetry factor (glum) and long-term stability. Here, we report a strategy for the design and synthesis of luminescent cholesteric liquid crystal elastomer (Lumin-CLCE) films with mechanically tunable CPL, which is enabled by liquid crystal-templated chiral self-assembly and in situ covalent cross-linking of judiciously designed photopolymerizable CsPbX3 (X = Cl, Br, I) PQD nanomonomers into the elastic polymer networks...
March 25, 2024: Angewandte Chemie
https://read.qxmd.com/read/38525059/click-chemistry-modifications-for-the-selective-crosslinking-of-wood-pulp-fibers-effect-on-the-physical-and-mechanical-properties-of-paper
#8
JOURNAL ARTICLE
Abdelhadi Blal, François Brouillette, Éric Loranger, Gilbert Lebrun
The Cu(i)-catalyzed Huisgen cycloaddition click chemistry reaction is of particular interest in the production of paper sheets or natural fiber composites since it leads to the formation of chemically stable bonds between two fibers. This study focuses on the click chemistry modification of kraft pulp fibers. We based our approach on prior research that treated kraft fibers using click chemistry, including propargylation and tosylation reactions. Our focus was on enhancing these treatments to achieve better final sheet properties...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38522291/green-immobilization-enhancing-enzyme-stability-and-reusability-on-eco-friendly-support
#9
JOURNAL ARTICLE
Vesen Atiroğlu, Atheer Atiroğlu, Ahmed Atiroğlu, Ali Sultan Al-Hajri, Mahmut Özacar
In the current years of heightened focus on green chemistry and sustainable materials, this study delves into the untapped potential of hyaluronic acid (HA), chitin, and chitosan-prominent polysaccharides for groundbreaking applications. The primary aim is to effectively immobilize catalase enzymes onto matrices composed of chitosan, chitin, HA/chitin, and HA/chitosan. The rigorous investigation covers a spectrum of structural enhancements encompassing pH and temperature stability, thermal resilience, half-life extension, storage durability, reusability, and comprehensive FTIR analyses of the catalase immobilization...
March 12, 2024: Food Chemistry
https://read.qxmd.com/read/38508569/enhancing-enzyme-immobilization-fabrication-of-biosilica-based-organic-inorganic-composite-carriers-for-efficient-covalent-binding-of-d-allulose-3-epimerase
#10
JOURNAL ARTICLE
Ziqun Xiao, Zishen Zhao, Bo Jiang, Jingjing Chen
D-allulose, an ideal low-calorie sweetener, is primarily produced through the isomerization of d-fructose using D-allulose 3-epimerase (DAE; EC 5.1.3.30). Addressing the gap in available immobilized DAE enzymes for scalable commercial D-allulose production, three core-shell structured organic-inorganic composite silica-based carriers were designed for efficient covalent immobilization of DAE. Natural inorganic diatomite was used as the core, while 3-aminopropyltriethoxysilane (APTES), polyethyleneimine (PEI), and chitosan organic layers were coated as the shells, respectively...
March 18, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38499462/a-crown-ether-based-elastomer-bearing-loop-structures-with-dissipating-characteristics-and-enhanced-mechanical-performance
#11
JOURNAL ARTICLE
Dong Zhao, Zhaoming Zhang, Zhiyou Wei, Jun Zhao, Tao Li, Xuzhou Yan
Loops are prevalent topological structures in cross-linked polymer networks, resulting from the folding of polymer chains back onto themselves. Traditionally, they have been considered as defects that compromise the mechanical properties of the network, leading to extensive efforts in synthesis to prevent their formation. In this study, we introduce the inclusion of cyclic dibenzo-24-crown-8 (DB24C8) moieties within the polymer network strands to form CCNs, and surprisingly, these loops enhance the mechanical performances of the network, leading to tough elastomers...
March 18, 2024: Angewandte Chemie
https://read.qxmd.com/read/38498000/mass-spectrometry-based-method-to-measure-aflatoxin-b-1-dna-adducts-in-formalin-fixed-paraffin-embedded-tissues
#12
JOURNAL ARTICLE
Medjda Bellamri, Lihua Yao, Rachana Tomar, Vladimir Vartanian, Carmelo J Rizzo, Michael P Stone, John D Groopman, R Stephen Lloyd, Robert J Turesky
Aflatoxin B1 (AFB1 ) is a potent human liver carcinogen produced by certain molds, particularly Aspergillus flavus and Aspergillus parasiticus , which contaminate peanuts, corn, rice, cottonseed, and ground and tree nuts, principally in warm and humid climates. AFB1 undergoes bioactivation in the liver to produce AFB1 - exo -8,9-epoxide, which forms the covalently bound cationic AFB1 - N 7-guanine (AFB1 -N 7-Gua) DNA adduct. This adduct is unstable and undergoes base-catalyzed opening of the guanine imidazolium ring to form two ring-opened diastereomeric 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy-aflatoxin B1 (AFB1 -FapyGua) adducts...
March 18, 2024: Chemical Research in Toxicology
https://read.qxmd.com/read/38494226/antibacterial-adhesive-based-on-oxidized-tannic-acid-chitosan-for-rapid-hemostasis
#13
JOURNAL ARTICLE
Z Khosravi, M Kharaziha, R Goli, F Karimzadeh
Currently, bacterial infections and bleeding interfere with wound healing, and multifunctional hydrogels with appropriate blood homeostasis, skin adhesion, and antibacterial activity are desirable. In this study, chitosan-based hydrogels were synthesized using oxidized tannic acid (OTA) and Fe3+ as cross-linkers (CS-OTA-Fe) by forming covalent, non-covalent, and metal coordination bonds between Fe3+ and OTA. Our results demonstrated that CS-OTA-Fe hydrogels showed antibacterial properties against Gram-positive bacteria (Staphylococcus aureus)and Gram-negative bacteria (Escherichia coli), low hemolysis rate (< 2 %), rapid blood clotting ability, in vitro (< 2 min), and in vivo (90 s) in mouse liver bleeding...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38489506/catalyst-free-%C3%AE-acetyl-cinnamate-acetoacetate-exchange-to-enable-high-creep-resistant-vitrimers
#14
JOURNAL ARTICLE
Hongzhi Feng, Sheng Wang, Jason Y C Lim, Bofan Li, Wendy Rusli, Feng Liu, Nikos Hadjichristidis, Zibiao Li, Jin Zhu
Vitrimers represent an emerging class of polymeric materials that combine the desirable characteristics of both thermoplastics and thermosets achieved through the design of dynamic covalent bonds within the polymer networks. However, these materials are prone to creep due to the inherent instability of dynamic covalent bonds. Consequently, there are pressing demands for the development of robust and stable dynamic covalent chemistries. Here, we report a catalyst-free α-acetyl cinnamate/acetoacetate (α-AC/A) exchange reaction to develop vitrimers with remarkable creep resistance...
March 15, 2024: Angewandte Chemie
https://read.qxmd.com/read/38488218/versatile-mechanically-tunable-hydrogels-for-therapeutic-delivery-applications
#15
JOURNAL ARTICLE
Qiyao Sun, Siyuan Tao, Giovanni Bovone, Garam Han, Dhananjay Deshmukh, Mark W Tibbitt, Qun Ren, Pascal Bertsch, Gilberto Siqueira, Peter Fischer
Hydrogels provide a versatile platform for biomedical material fabrication that can be structurally and mechanically fine-tuned to various tissues and applications. Applications of hydrogels in biomedicine range from highly dynamic injectable hydrogels that can flow through syringe needles and maintain or recover their structure after extrusion to solid-like wound-healing patches that need to be stretchable while providing a selective physical barrier. In this study, a toolbox is designed using thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) polymeric matrices and nanocelluloses as reinforcing agent to obtain biocompatible hydrogels with altering mechanical properties, from a liquid injectable to a solid-like elastic hydrogel...
March 15, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38475305/external-stimuli-induced-welding-of-dynamic-cross-linked-polymer-networks
#16
REVIEW
Yun Liu, Sheng Wang, Jidong Dong, Pengfei Huo, Dawei Zhang, Shuaiyuan Han, Jie Yang, Zaixing Jiang
Thermosets have been crucial in modern engineering for decades, finding applications in various industries. Welding cross-linked components are essential in the processing of thermosets for repairing damaged areas or fabricating complex structures. However, the inherent insolubility and infusibility of thermoset materials, attributed to their three-dimensional network structure, pose challenges to welding development. Incorporating dynamic chemical bonds into highly cross-linked networks bridges the gap between thermosets and thermoplastics presenting a promising avenue for innovative welding techniques...
February 24, 2024: Polymers
https://read.qxmd.com/read/38474470/synthesis-and-characterization-of-durable-antifog-silane-pyrrolidone-thin-coatings-onto-polymeric-films
#17
JOURNAL ARTICLE
Natalie Mounayer, Taly Iline-Vul, Shlomo Margel
The fogging of transparent surfaces-condensation of water vapor in the air to a small liquid surface at specific environmental conditions-scatters incident light, creating a blurry vision. Fogging presents a significant challenge in various industries, adversely affecting numerous applications including plastic packaging, agricultural films, and various optical devices. Superhydrophobic or superhydrophilic coatings are the main strategies used to induce antifogging to minimize light scattering. Here, an innovative approach is introduced to mitigate fogging by modifying the surface properties of polymeric films, focusing on corona-treated polyethylene as a model...
February 22, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38466925/ligand-assisted-direct-lithography-of-upconverting-and-avalanching-nanoparticles-for-nonlinear-photonics
#18
JOURNAL ARTICLE
Jia-Ahn Pan, Artiom Skripka, Changhwan Lee, Xiao Qi, Anne L Pham, Joshua J Woods, Rebecca J Abergel, P James Schuck, Bruce E Cohen, Emory M Chan
Upconverting nanoparticles (UCNPs) exhibit unique nonlinear optical properties that can be harnessed in microscopy, sensing, and photonics. However, forming high-resolution nano- and micropatterns of UCNPs with large packing fractions is still challenging. Additionally, there is limited understanding of how nanoparticle patterning chemistries are affected by the particle size. Here, we explore direct patterning chemistries for 6-18 nm Tm3+ -, Yb3+ /Tm3+ -, and Yb3+ /Er3+ -based UCNPs using ligands that form either new ionic linkages or covalent bonds between UCNPs under ultraviolet (UV), electron-beam (e-beam), and near-infrared (NIR) exposure...
March 11, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38462121/polymerizable-rotaxane-of-cucurbituril-protecting-dopamine-based-adhesive-hydrogels
#19
JOURNAL ARTICLE
Yunpeng Gao, Xin Tian, Xueru Xiong, Yushi Wang, Wen Huang, Xuetao Shi, Yong-Guang Jia, Zhong-Kai Cui
The catechol moiety found within mussel proteins plays a pivotal role in enhancing their adhesive properties. Nonetheless, catechol compounds, such as dopamine (DOP) derivatives, are susceptible to oxidation, leading to the formation of q0uinone. This oxidation process poses a significant challenge in the development of DOP-based hydrogels, hampering their adhesion capabilities and hindering polymerization. To protect DOP moieties from oxidation, DOP and N-(3-aminopropyl)methacrylamide (AMA) moieties were grafted onto the side groups of biocompatible poly(glutamic acid) (PGA)...
March 8, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38460650/structural-determinants-of-odorant-binding-proteins-affecting-their-ability-to-form-amyloid-fibrils
#20
JOURNAL ARTICLE
Anna I Sulatskaya, Olga V Stepanenko, Maksim I Sulatsky, Ekaterina V Mikhailova, Irina M Kuznetsova, Konstantin K Turoverov, Olesya V Stepanenko
The formation of amyloid fibrils is associated with many severe pathologies as well as the execution of essential physiological functions by proteins. Despite the diversity, all amyloids share a similar morphology and consist of stacked β-strands, suggesting high amyloidogenicity of native proteins enriched with β-structure. Such proteins include those with a β-barrel-like structure with β-strands arranged into a cylindrical β-sheet. However, the mechanisms responsible for destabilization of the native state and triggering fibrillogenesis have not thoroughly explored yet...
March 7, 2024: International Journal of Biological Macromolecules
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