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All hydrocarbon tether

Johanna Aurell, David Hubble, Brian K Gullett, Amara Holder, Ephraim Washburn, Dennis Tabor
The effect of accidental fires are simulated to understand the response of items such as vehicles, fuel tanks, and military ordnance and to remediate the effects through re-design of the items or changes in operational procedures. The comparative combustion emissions of using jet propellant (JP-5) liquid fuel pools or a propane manifold grid to simulate the effects of accidental fires was investigated. A helium-filled tethered aerostat was used to maneuver an instrument package into the open fire plumes to measure CO, CO2, fine particulate matter (PM2...
November 7, 2017: Fire Technology
D Thirion, V Rozyyev, J Park, J Byun, Y Jung, M Atilhan, C T Yavuz
Liquid, solvated amine based carbon capture is the core of all commercial or planned CO2 capture operations. Despite the intense research, few have looked systematically into the nature of amine molecules and their CO2 interaction. Here, we report a systematic introduction of linear ethylene amines on the walls of highly porous Davankov type network structures through simple bromination intermediates. Surprisingly, isosteric heats of CO2 adsorption show a clear linear trend with the increase in the length of the tethered amine pendant groups, leading to a concerted cooperative binding with additional H-bonding contributions from the unassociated secondary amines...
June 7, 2016: Physical Chemistry Chemical Physics: PCCP
Lutz Ackermann, Sergei I Kozhushkov, Dmitry S Yufit
Intermolecular hydroarylation reactions of highly strained methylenecyclopropanes 2-phenylmethylenecyclopropane (1), 2,2-diphenylmethylenecyclopropane (2), methylenespiropentane (3), bicyclopropylidene (4), (dicyclopropylmethylene)cyclopropane (5), and benzhydrylidenecyclopropane (6) through C-H bond functionalization of 2-phenylpyridine (7 a) and other arenes with directing groups were studied. The reaction was very sensitive to the substitution on the methylenecyclopropanes. Although these transformations involved (cyclopropylcarbinyl)-metal intermediates, substrates 1 and 4 furnished anti-Markovnikov hydroarylation products with complete conservation of all cyclopropane rings in 11-93 % yield, whereas starting materials 3 and 5 were inert toward hydroarylation...
September 17, 2012: Chemistry: a European Journal
Jonathan S Lindsey, David F Bocian
The inexorable drive to miniaturize information storage and processing devices has fueled the dreams of scientists pursuing molecular electronics: researchers in the field envisage exquisitely tailored molecular materials fulfilling the functions now carried out by semiconductors. A bottom-up assembly of such all-molecular devices would complement, if not supplant, the present top-down lithographic procedures of modern semiconductor fabrication. Short of these grand aspirations, a more near-term objective is to construct hybrid architectures wherein molecules are incorporated in semiconductor-based devices...
August 16, 2011: Accounts of Chemical Research
Young-Woo Kim, Gregory L Verdine
The stereochemical effects of the hydrocarbon crosslink on the conformation and cellular uptake of i,i+4 stapled peptides were studied. Compared to its S,S-configurated counterpart, the crosslink bearing the R,R-configuration provided a significantly diminished helix stabilizing effect and conferred less efficient cellular uptake on the stapled peptides. These results suggest that the vesicular trafficking pathway employed by cells to take up stapled peptides is sensitive to the extent of helical character in the peptide, with greater helicity conferring increased cellular uptake...
May 1, 2009: Bioorganic & Medicinal Chemistry Letters
Dan Rizkov, Shaul Mizrahi, Jenny Gun, Roy Hoffman, Artem Melman, Ovadia Lev
A generic family of low molecular weight binary gels comprising beta-cyclodextrin (beta-CD) and one of a large variety of polyaromatic hydrocarbons (PAHs) in dimethylformamide (DMF), pyridine, and other polar solvents is described. The system is rather general and robust. It tolerates large changes in each of the major ingredients without losing gelation ability. alpha- and gamma-CD, and negatively or positively modified beta-CD (e.g., sulfate-, phosphate-, or amine-tethered beta-CD) as well as methylated beta-CD are all effective gelators...
October 21, 2008: Langmuir: the ACS Journal of Surfaces and Colloids
James N Wilson, Eric T Kool
We describe the design, synthesis, and properties of nucleoside monomers in which the DNA base is replaced by fluorescent hydrocarbons and heterocycles, and the assembly of these monomers into DNA-like molecules in which the all bases are fluorescent. As monomers, such molecules have useful applications as reporters in the DNA context. The use of fluorescent DNA bases, rather than more traditional fluorophores tethered to the DNA strand, gives a more predictable location and orientation, and yields a more direct response to changes that occur within the helix...
December 7, 2006: Organic & Biomolecular Chemistry
Markus Kaiser, Anne De Cian, Matthieu Sainlos, Christian Renner, Jean-Louis Mergny, Marie-Paule Teulade-Fichou
A series of aminoglycoside-capped macrocyclic structures has been prepared using intramolecular bis-tethering of neomycin on three aromatic platforms (phenanthroline, acridine, quinacridine). Based on NMR and calculations studies, it was found that the cyclic compounds adopt a highly flexible structure without conformational restriction of the aminoglycoside moiety. FRET-melting stabilization measurements showed that the series displays moderate to high affinity for the G4-conformation of human telomeric repeats, this effect being correlated with the size of the aromatic moiety...
March 21, 2006: Organic & Biomolecular Chemistry
Thomas M Bertolini, Jennifer Giorgione, Daniel F Harvey, Alexandra C Newton
Several novel phorbol esters were prepared with polar functional groups terminating their C12 and/or C13 acyl chains. Designed to be inhibitory protein kinase C (PKC) ligands, these phorbol analogues contain various polar functional groups (amide, ester, carboxylic acid, or quaternary ammonium salt) to prevent membrane insertion of the PKC-phorbol ester complex. All phorbol derivatives were synthesized with use of diterpene starting materials obtained from croton oil, the seed oil of Croton tiglium. The ability of these derivatives to recruit PKC to the lipid bilayer-a usual requirement for enzyme activation-was determined by using a sucrose-loaded vesicle assay...
June 27, 2003: Journal of Organic Chemistry
H Shimada, J B Grutzner, J F Kozlowski, J L McLaughlin
Certain plant species belonging to the family Annonaceae produce Annonaceous acetogenins, which are a unique class of long-chain fatty acid derivatives with potent cytotoxicity. Putative protein targets of the acetogenins are membrane-associated proteins, including complex I. Asimicin and its analogues constitute a class of Annonaceous acetogenins containing two tetrahydrofuran (THF) rings with hydrocarbon chains tethered to each ring; an alpha,beta-unsaturated gamma-lactone ring is terminal to one of the alkyl chains...
January 20, 1998: Biochemistry
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