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https://www.readbyqxmd.com/read/29336597/navigating-emotions-and-relationship-dynamics-family-life-review-as-a-clinical-tool-for-older-adults-during-a-relocation-transition-into-an-assisted-living-facility
#1
Kendra A O'Hora, Karen A Roberto
OBJECTIVE: Relocation for the purpose of receiving care may be one of the more challenging transitions for older adults. The purpose of this study was to facilitate a family life review (FLR) session aimed at enhancing family relationships and assisting older adults in coping with the challenges associated with a relocation. METHODS: Fourteen dyads comprised of older adults who relocated to an assisted living facility (ALF) and a chosen family member or friend participated in a FLR session and semi-structured follow up interview...
January 16, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29329640/capturing-real-life-forgetting-in-transient-epileptic-amnesia-via-an-incidental-memory-test
#2
Serge Hoefeijzers, Adam Zeman, Sergio Della Sala, Michaela Dewar
Transient epileptic amnesia (TEA) is an epileptic syndrome characterized by recurrent, brief episodes of amnesia. Patients with TEA often complain of interictal (between attacks) retention deficits, characterised by an 'evaporation' of memories for recent events over days to weeks. Clinical tests of anterograde memory often fail to corroborate these complaints as TEA patients commonly perform within the normal range after the standard 10-30-min delay period. Modified laboratory tests that include a 1-3 week delay period frequently reveal clear evidence of 'accelerated long-term forgetting' (ALF)...
December 13, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29327522/clinical-profile-and-outcome-of-pregnant-patients-with-acute-hev-hepatitis-during-water-borne-epidemic-in-himachal-pradesh-a-hospital-based-study
#3
Asha Ranjan, Surinder Thakur, Jatinder Mokta, Rajesh Bhawani, Varsha Ranjan
Background: Recent outbreak of HEV hepatitis epidemic in Himachal Pradesh in Shimla caused significant morbidity and mortality especially among pregnant patients. Overall mortality is 0.5- 4% in patients developing acute hepatic failure (ALF) and is significantly higher in pregnant patients (20%). Present study conducted to observe clinical profile and outcome in pregnant patients. Methodology: this is a retrospective observational study done on admitted pregnant and post partum patients with acute HEV hepatitis during 3 months periods...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29321429/early-combination-therapy-with-corticosteroid-and-nucleoside-analogue-induces-rapid-resolution-of-inflammation-in-acute-liver-failure-due-to-transient-hepatitis-b-virus-infection
#4
Keiichi Fujiwara, Shin Yasui, Yuuki Haga, Masato Nakamura, Yutaka Yonemitsu, Makoto Arai, Tatsuo Kanda, Shigeto Oda, Osamu Yokosuka, Naoya Kato
Objective Patients with acute hepatitis B sometimes develop acute liver failure (ALF), which has a poor prognosis. The efficacy of nucleoside analogue (NA) monotherapy for ALF due to transient hepatitis B virus infection (HBV-ALF) remains controversial. Further investigations are necessary in nations with a shortage of donor livers for liver transplantation. In the present study, we aimed to clarify the efficacy of combination therapy with corticosteroid (CS) and NA in the treatment HBV-ALF. Patients We examined the clinical and biochemical features of 19 patients with HBV-ALF who were treated in the early stage of the disease between 2000 and 2015...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29321049/human-liver-organoids-generated-with-single-donor-derived-multiple-cells-rescue-mice-from-acute-liver-failure
#5
Yun-Zhong Nie, Yun-Wen Zheng, Miyuki Ogawa, Etsuko Miyagi, Hideki Taniguchi
BACKGROUND: Acute liver failure (ALF) is a life-threatening disease with a high mortality rate. However, there are limited treatments or devices available for ALF therapy. Here, we aimed to develop a new strategy for ALF treatment by transplanting functional liver organoids (LOs) generated from single donor-derived human induced pluripotent stem cell (hiPSC) endoderm, endothelial cells (ECs), and mesenchymal cells (MCs). METHODS: First, we isolated ECs and MCs from a single donor umbilical cord (UC) through enzyme digestion and characterized the UC-ECs and UC-MCs by flow cytometry...
January 10, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29308949/a-comparison-of-two-manual-physical-therapy-approaches-and-electrotherapy-modalities-for-patients-with-knee-osteoarthritis-a-randomized-three-arm-clinical-trial
#6
Ebru Kaya Mutlu, Ersin Ercin, Arzu Razak Ozdıncler, Nadir Ones
A broad spectrum of physical therapy exercise programs provides symptom relief and functional benefit for patients with knee OA. Manual physical therapy, including tailored exercise programs provide relatively higher level benefit that persists to one year. It is currently unknown if there are important differences in the effects of different manual physical therapy techniques for patients with knee OA and there are virtually no studies comparing manual physical therapy and electrotherapy modalities. The aim of the study was to compare long-term results between three treatment groups (mobilization with movements [MWMs], passive joint mobilization [PJM], and electrotherapy) to determine which treatment is most effective in patients with knee OA...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29305174/inhibition-of-autophagy-reverses-alcohol-induced-hepatic-stellate-cells-activation-through-activation-of-nrf2-keap1-are-signaling-pathway
#7
Zheng-Yuan Xie, Zhi-Hua Xiao, Fen-Fen Wang
BACKGROUND: Numerous documents have indicated a critical role of autophagy in alcoholic liver fibrosis (ALF), but few papers have reported its function in hepatic stellate cells (HSCs) activation. The current study aimed to investigate the regulation effect of autophagy in HSCs activation, in further to explore the underlying mechanism involved. METHODS: HSC-T6 cells were treated with ethanol, 3-MA (autophagy inhibitor) or rapamycin (autophagy inducer), and cells were also transfected with si-Nrf2 or si-Keap1...
January 2, 2018: Biochimie
https://www.readbyqxmd.com/read/29291180/delta-model-for-end-stage-liver-disease-and-delta-clinical-prognostic-indicator-as-predictors-of-mortality-in-patients-with-viral-acute-liver-failure
#8
Ashok Kumar Pannu, Ashish Bhalla, Chelapati Rao, Charanpreet Singh
Objective: The objective of the study is to compare the model for end-stage liver disease (MELD) with clinical prognostic indicators (CPI) specifically the change in these parameters after 48 h of admission in predicting the mortality in patients with acute liver failure (ALF) due to acute viral hepatitis. Materials and Methods: An open label, investigator-initiated prospective study was conducted that included 41 patients with acute viral hepatitis with ALF. The cases were followed prospectively till death or discharge...
October 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29288814/immune-response-of-exopalaemon-carinicauda-infected-with-an-ahpnd-causing-strain-of-vibrio-parahaemolyticus
#9
Qianqian Ge, Jian Li, Jitao Li, Jiajia Wang, Zhengdao Li
To investigate the immune response of Exopalaemon carinicauda infected with an AHPND-causing strain of Vibrio parahaemolyticus (VPAHPND), three-generation breeding of shrimp selected for their survival to VPAHPND infection was applied to explore the relationship between immune parameters and AHPND-resistant capacity of E. carinicauda. In this study, the LD50 dose of 48 h and survival rates at 144 h of shrimp to VPAHPND increased from 106.0 to 106.6 cfu ml-1 and from 26.67% to 36.67% by three successive generations selection, respectively, while there was no significant difference between the first and second generation (p > ...
December 27, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29284048/the-mediating-effect-of-body-mass-index-on-the-relationship-between-smoking-and-hip-or-knee-replacement-due-to-primary-osteoarthritis-a-population-based-cohort-study-the-hunt-study
#10
Marianne Bakke Johnsen, Alf Inge Hellevik, Milada Cvancarova Småstuen, Arnulf Langhammer, Ove Furnes, Gunnar Birkeland Flugsrud, Lars Nordsletten, John Anker Zwart, Kjersti Storheim
To investigate the total effect of smoking on total hip or knee replacement (THR/TKR) due to primary osteoarthritis (OA) and to quantify the indirect effect of smoking through body mass index (BMI). Participants from the Nord-Trøndelag Health Study (the HUNT Study) were linked to the Norwegian Arthroplasty Register to detect the first THR or TKR due to primary OA. A mediation analysis was used to decompose the total effect of smoking into a direct and indirect effect. BMI was considered a mediator in the analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29273827/stimulation-of-intestinal-calcium-absorption-by-orally-administrated-vitamin-d3-compounds-a-prospective-open-label-randomized-trial-in-osteoporosis
#11
K Uenishi, M Tokiwa, S Kato, M Shiraki
Intestinal fractional calcium absorption (FCA) was assessed before and after vitamin D3 treatment. Serum 1,25(OH)2D concentration was significantly increased by plain vitamin D3 and reduced by eldecalcitol. The 1α hydroxyl calcidiol and eldecalcitol treatments increased FCA, which may be induced through direct stimulation of vitamin D receptors in the intestine. INTRODUCTION: To assess the effects of vitamin D3 compounds on intestinal FCA and calcium-regulating hormones in post-menopausal osteoporosis, a randomized open-label prospective study was conducted...
December 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29262369/sarcomere-stiffness-during-stretching-and-shortening-of-rigor-skeletal-myofibrils
#12
Nabil Shalabi, Malin Persson, Alf Månsson, Srikar Vengallatore, Dilson E Rassier
In this study, we measured the stiffness of skeletal muscle myofibrils in rigor. Using a custom-built atomic force microscope, myofibrils were first placed in a rigor state then stretched and shortened at different displacements (0.1-0.3 μm per sarcomere) and nominal speeds (0.4 and 0.8 μm/s). During stretching, the myofibril stiffness was independent of both displacement and speed (average of 987 nN/μm). During shortening, the myofibril stiffness was independent of displacement, but dependent on speed (1234 nN/μm at 0...
December 19, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29260267/-responsibilities-and-concepts-for-undergraduate-and-postgraduate-medical-education-in-germany-a%C3%A2-plea-for-a%C3%A2-reorientation
#13
REVIEW
Hendrik van den Bussche, Detlef Niemann, Bernt-Peter Robra, Udo Schagen, Beate Schücking, Nobert Schmacke, Claudia Spies, Alf Trojan, Uwe Koch-Gromus
BACKGROUND: Undergraduate medical education in Germany takes place in the medical faculties of universities, whereas postgraduate medical education takes place in nearly all hospitals under the aegis of medical associations. Both phases of the medical qualification process live on their own; the communication between the two responsible bodies is negligible. Previous reforms have always tackled undergraduate education only, whereas postgraduate education takes place without public attention...
December 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29258923/circle-scanning-sted-fluorescence-correlation-spectroscopy-to-quantify-membrane-dynamics-and-compartmentalization
#14
Riccardo Maraspini, Oliver Beutel, Alf Honigmann
Quantifying molecular dynamics of cell membrane constituents is required to understand organization and function of biological membranes. Because of its complex structure unambiguous interpretation of molecular membrane dynamics requires high spatial and temporal resolution measurements. In this paper, we provide a comprehensive description of circle scanning fluorescence correlation spectroscopy and its combination with stimulated emission depletion microscopy (CS-STED-FCS). This method allows quantification of sub-diffusion processes and direct mapping of heterogeneities in membranes with high spatiotemporal resolution...
December 16, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29248328/global-carbon-cycling-on-a-heterogeneous-seafloor
#15
REVIEW
Paul V R Snelgrove, Karline Soetaert, Martin Solan, Simon Thrush, Chih-Lin Wei, Roberto Danovaro, Robinson W Fulweiler, Hiroshi Kitazato, Baban Ingole, Alf Norkko, R John Parkes, Nils Volkenborn
Diverse biological communities mediate the transformation, transport, and storage of elements fundamental to life on Earth, including carbon, nitrogen, and oxygen. However, global biogeochemical model outcomes can vary by orders of magnitude, compromising capacity to project realistic ecosystem responses to planetary changes, including ocean productivity and climate. Here, we compare global carbon turnover rates estimated using models grounded in biological versus geochemical theory and argue that the turnover estimates based on each perspective yield divergent outcomes...
December 13, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29243062/pre-clinical-study-of-a-tnfr1-targeted-18f-probe-for-pet-imaging-of-breast-cancer
#16
Hao Fu, Hua Wu, Xianzhong Zhang, Jinxiong Huang, Xiaojiang He, Lichun Chen, Wei Guo, Xiuyu Guo, Bing Hao, Yesen Li
Tumor necrosis factor receptor 1 (TNFR1) is overexpressed in several varieties of carcinoma, including breast cancer. WH701 (Ala-Thr-Ala-Gln-Ser-Ala-Tyr-Gly), which was identified by phage display, can specifically bind to TNFR1. In this study, we labeled WH701 with 18F and investigated its tumor diagnostic value. WH701 was synthesized by standard Fmoc-solid phase synthetic protocols and conjugated by NOTA-NHS. NOTA-WH701 was radiolabeled with 18F using NOTA-AlF chelation reaction. The tumor target properties were evaluated in vitro and in vivo using MCF-7 xenografts and inflammation models...
December 14, 2017: Amino Acids
https://www.readbyqxmd.com/read/29238640/high-risk-subgroup-membership-is-a-predictor-of-30-day-morbidity-following-anterior-lumbar-fusion
#17
Rachel S Bronheim, Jun S Kim, John Di Capua, Nathan J Lee, Parth Kothari, Sulaiman Somani, Kevin Phan, Samuel K Cho
Study Design: Retrospective cohort study. Objective: To determine if membership in a high-risk subgroup is predictive of morbidity and mortality following anterior lumbar fusion (ALF). Methods: The American College of Surgeons National Surgical Quality Improvement Program database was utilized to identify patients undergoing ALF between 2010 and 2014. Multivariate analysis was utilized to identify high-risk subgroup membership as an independent predictor of postoperative complications...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29237659/long-term-follow-up-of-hepatitis-associated-aplastic-anaemia
#18
Cristina Gonçalves, Sandra Ferreira, Susana Nobre, Isabel Gonçalves
Prognosis of hepatitis-associated aplastic anaemia (HAAA) was improved with haematopoietic stem cell transplantation (HSCT) and immunosuppression, but the long-term outcome remains undefined. Case 1: a girl aged 3 years with acute liver failure (ALF) submitted to orthotopic liver transplantation (OLT) subsequently developed aplastic anaemia and HSCT from a compatible sibling was performed. Post-HSCT, the patient developed post-transplant lymphoproliferative disorder and rituximab was administered with good response...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29222960/drug-induced-acute-liver-failure-in-children-and-adults-results-of-a-single-center-study-of-128-patients
#19
Harshad Devarbhavi, Mallikarjun Patil, Vishnu Vardhan Reddy, Rajvir Singh, Tarun Joseph, Deepak Ganga
BACKGROUND AND AIMS: Drugs producing acute liver failure (ALF) are uncommon and vary geographically. Here we review the implicated drugs, clinical features, laboratory characteristics and outcome of patients with drug-induced ALF (DIALF). We analyzed the predictors of mortality and their relationship with MELD, Kings College criteria (KCC) and ALFSG prognostic index. METHODS: We identified DIALF patients from our drug-induced liver injury (DILI) registry (1997-2017)...
December 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29218090/mir-24-regulates-hepatocyte-apoptosis-via-bim-during-acute-liver-failure
#20
Zhiwen Feng, Zhi Li, Deming Zhu, Wei Ling, Lei Zheng, Liyong Pu, Lianbao Kong
Acuteliver failure (ALF) has a high mortality rate and is characterized by massive hepatocyte destruction. Although microRNAs (miRNAs) play an important role in manyliver diseases, the role of miRNAs in ALF development is unknown. In this study, the murine ALF model was induced by intraperitoneal injection of D-galactosamine/lipopolysaccharide (D-GalN/LPS). Compared with saline-treated mice, miR-24 was distinctly down-regulated post D-GalN/LPS challenge in vivo and D-galactosamine/tumor necrosis factor (D-GalN/TNF) challenge in vitro, which was confirmed by quantitative real-time polymerase chain reaction...
2017: American Journal of Translational Research
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