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https://www.readbyqxmd.com/read/28746132/three-dimensional-cross-platform-planning-for-complex-spinal-procedures-a-new-method-adaptive-to-different-navigation-systems
#1
Michael Kosterhon, Angelika Gutenberg, Sven R Kantelhardt, Jens Conrad, Amr Nimer Amr, Joachim Gawehn, Alf Giese
STUDY DESIGN: A feasibility study. OBJECTIVE: To develop a method based on the DICOM standard which transfers complex 3-dimensional (3D) trajectories and objects from external planning software to any navigation system for planning and intraoperative guidance of complex spinal procedures. SUMMARY OF BACKGROUND DATA: There have been many reports about navigation systems with embedded planning solutions but only few on how to transfer planning data generated in external software...
August 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28745065/assessment-of-oral-anticoagulant-use-in-residents-of-long-term-care-homes-evidence-for-contemporary-suboptimal-use
#2
Carlos H Rojas-Fernandez, Joslin Goh, Jennifer Hartwick, Ruth Auber, Aein Zarrin, Melissa Warkentin, Zain Hudani
OBJECTIVE: To describe the quality of warfarin use in residents of long-term care facilities and investigate potential predictors oral anticoagulant use. DESIGN: Retrospective chart review (August 2013 to September 2014). SETTING: Thirteen long-term care (LTC) and assisted living facilities (ALF). PARTICIPANTS: Residents from LTC or ALF settings who ( a) received warfarin or direct-acting oral anticoagulants (DOACs) and ( b) residents with a valid indication for oral anticoagulants such as atrial fibrillation, venous thromboembolism, but were not receiving these drugs...
July 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28742911/targeted-temperature-management-for-48-vs-24-hours-and-neurologic-outcome-after-out-of-hospital-cardiac-arrest-a-randomized-clinical-trial
#3
Hans Kirkegaard, Eldar Søreide, Inge de Haas, Ville Pettilä, Fabio Silvio Taccone, Urmet Arus, Christian Storm, Christian Hassager, Jørgen Feldbæk Nielsen, Christina Ankjær Sørensen, Susanne Ilkjær, Anni Nørgaard Jeppesen, Anders Morten Grejs, Christophe Henri Valdemar Duez, Jakob Hjort, Alf Inge Larsen, Valdo Toome, Marjaana Tiainen, Johanna Hästbacka, Timo Laitio, Markus B Skrifvars
Importance: International resuscitation guidelines recommend targeted temperature management (TTM) at 33°C to 36°C in unconscious patients with out-of-hospital cardiac arrest for at least 24 hours, but the optimal duration of TTM is uncertain. Objective: To determine whether TTM at 33°C for 48 hours results in better neurologic outcomes compared with currently recommended, standard, 24-hour TTM. Design, Setting, and Participants: This was an international, investigator-initiated, blinded-outcome-assessor, parallel, pragmatic, multicenter, randomized clinical superiority trial in 10 intensive care units (ICUs) at 10 university hospitals in 6 European countries...
July 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28736976/living-donor-liver-transplantation-for-neonatal-fulminant-hepatitis-due-to-herpes-simplex-virus-infection
#4
Rodrigo Vincenzi, Eduardo A Fonseca, Karina M O Roda, Gilda Porta, Helry L Candido, Marcel R Benavides, Katia R M Leite, Rogerio C Afonso, Plinio Turine-Neto, Cristiane M F Ribeiro, Paulo Chapchap, João Seda-Neto
Although rare, ALF caused by disseminated HSV infection is associated with high mortality in the neonatal population. This condition is often diagnosed relatively late due to the absence of specific signs. We present a case involving a neonate with ALF submitted to living donor liver transplantation without a prior diagnosis. The patient had no skin or mucosal lesions, and IgM serology was negative for HSV-1 and HSV-2. Immunohistochemical staining of the liver explant was positive for herpes virus infection, and the patient subsequently received antiviral drug treatment, with a good outcome...
July 23, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28733538/the-abnormality-of-thyroid-hormones-in-patients-with-type-a-hepatic-encephalopathy
#5
Lin Wang, Wanyou Yu, Wukui Cao, Wei Lu
Abnormality of thyroid hormones in liver diseases is common, but data is lacking in patients with type A hepatic encephalopathy (HE). The present study was aimed to determine whether there was an abnormality in thyroid hormones among patients with type A HE. We measured the levels of thyroid hormones in 36 acute liver failure (ALF) patients with type A HE and in 29 acute liver injury patients (international normalized ratio, INR ≥ 1.5) without encephalopathy as control. The clinical parameters associated with abnormality of thyroid hormones were evaluated...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28729435/dysregulation-of-mir-223-constitutes-a-promising-biomarker-that-informs-about-clinical-outcomes-of-acute-liver-failure
#6
Volker M Lauschke
In this issue of Clinical Science, Schueller et al. [Clin. Sci. (2017) 131, 1971-1987] evaluated the role of miR-223 across multiple etiologies of acute and chronic liver insults in murine models and clinical samples. The authors find that while miR-223 is not mechanistically involved in liver injury, its intracellular levels in hepatocytes are increased upon hepatic damage in a broad panel of mechanistically distinct injury models. Furthermore, the authors provide evidence that circulating miR-223 levels provide a promising minimally invasive biomarker for acute liver failure (ALF) that defines a distinct subset of ALF cases and correlates with clinical outcomes...
August 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28722655/key-steps-in-unconventional-secretion-of-fibroblast-growth-factor-2-reconstituted-with-purified-components
#7
Julia P Steringer, Sascha Lange, Sabína Čujová, Radek Šachl, Chetan Poojari, Fabio Lolicato, Oliver Beutel, Hans-Michael Müller, Sebastian Unger, Ünal Coskun, Alf Honigmann, Ilpo Vattulainen, Martin Hof, Christian Freund, Walter Nickel
FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane. Here, we define the minimal molecular machinery required for FGF2 membrane translocation in a fully reconstituted inside-out vesicle system. FGF2 membrane translocation is thermodynamically driven by PI(4,5)P2-induced membrane insertion of FGF2 oligomers. The latter serve as dynamic translocation intermediates of FGF2 with a subunit number in the range of 8-12 FGF2 molecules...
July 19, 2017: ELife
https://www.readbyqxmd.com/read/28717178/prevalence-of-metabolic-syndrome-among-adults-with-liver-function-injury-in-rural-area-of-southwest-china-a-cross-sectional-study
#8
Hui Zeng, Hui Lin, Wenyi Liu, Jia Wang, Lingqiao Wang, Chuanfen Zheng, Yao Tan, Yujing Huang, Lixiong He, Jiaohua Luo, Chaowen Pu, Renping Zhang, Xiaohong Yang, Yingqiao Tian, Zhiqun Qiu, Ji-An Chen, Yang Luo, Xiaobin Feng, Guosheng Xiao, Liping Wu, Weiqun Shu
Abnormal liver function (ALF) plays a key role in metabolic syndrome (MetS), but only few data on the relationship between MetS and the risk factors for ALF (e.g., biotoxins) are available. We aimed to provide the prevalence of MetS and its association with the risk factors for ALF in rural area of Southwest China. A cross-sectional study within the hepatocellular carcinoma cohort was conducted, and included 5493 people with age from 30 to 85 years old. MetS was defined according to the Joint Scientific Statement...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714083/acute-liver-failure-with-amiodarone-infusion-a-case-report-and-systematic-review
#9
P Jaiswal, B M Attar, J E Yap, K Devani, R Jaiswal, Y Wang, R Szynkarek, D Patel, M Demetria
WHAT IS KNOWN AND OBJECTIVE: Amiodarone, a commonly used class III antiarrhythmic agent notable for a relatively long half-life of up to 6 months and its pronounced adverse effect profile, is used for both acute and chronic management of cardiac arrhythmias. Chronic use of amiodarone has been associated with asymptomatic hepatotoxicity; however, acute toxicity is thought to be uncommon. There are only six reported cases of acute liver failure (ALF) secondary to amiodarone. In all these cases the outcome of death during the same hospitalization resulted...
July 16, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28709622/genipin-protects-d-galactosamine-and-lipopolysaccharide-induced-hepatic-injury-through-suppression-of-the-necroptosis-mediated-inflammasome-signaling
#10
Min-Jong Seo, Jeong-Min Hong, Seok-Joo Kim, Sun-Mee Lee
Acute liver failure (ALF) is a life-threatening syndrome resulting from massive inflammation and hepatocyte death. Necroptosis, a programmed cell death controlled by receptor-interacting protein kinase (RIP) 1 and RIP3, has been shown to play an important role in regulating inflammation via crosstalk between other intracellular signaling. The inflammasome is a major intracellular multiprotein that induces inflammatory responses by mediating immune cell infiltration, thus potentiating injury. Genipin, a major active compound of the gardenia fruit, exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties...
July 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28705605/age-of-menarche-is-associated-with-knee-joint-replacement-due-to-primary-osteoarthritis-the-hunt-study-and-the-norwegian-arthroplasty-register
#11
A I Hellevik, L Nordsletten, M B Johnsen, A M Fenstad, O Furnes, K Storheim, J A Zwart, G Flugsrud, A Langhammer
OBJECTIVE: To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. METHOD: In a prospective cohort study of 30,289 women from the second and third surveys of the Nord-Trøndelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis...
July 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28694564/hmgb1-and-extracellular-histones-significantly-contribute-to-systemic-inflammation-and-multiple-organ-failure-in-acute-liver-failure
#12
REVIEW
Runkuan Yang, Xiaoping Zou, Jyrki Tenhunen, Tor Inge Tønnessen
Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes. ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity. ALF has a high mortality that is associated with multiple organ failure (MOF) and sepsis; however, the underlying mechanisms are still not clear. Emerging evidence shows that ALF patients/animals have high concentrations of circulating HMGB1, which can contribute to multiple organ injuries and mediate gut bacterial translocation (BT)...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28694160/artificial-neural-network-based-particle-size-prediction-of-polymeric-nanoparticles
#13
John Youshia, Mohamed Ehab Ali, Alf Lamprecht
Particle size of nanoparticles and the respective polydispersity are key factors influencing their biopharmaceutical behavior in a large variety of therapeutic applications. Predicting these attributes would skip many preliminary studies usually required to optimize formulations. The aim was to build a mathematical model capable of predicting the particle size of polymeric nanoparticles produced by a pharmaceutical polymer of choice. Polymer properties controlling the particle size were identified as molecular weight, hydrophobicity and surface activity, and were quantified by measuring polymer viscosity, contact angle and interfacial tension, respectively...
July 7, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28693567/protocol-based-invasive-intracranial-pressure-monitoring-in-acute-liver-failure-feasibility-safety-and-impact-on-management
#14
Venkatakrishna Rajajee, Robert J Fontana, Anthony J Courey, Parag G Patil
BACKGROUND: Acute liver failure (ALF) may result in elevated intracranial pressure (ICP). While invasive ICP monitoring (IICPM) may have a role in ALF management, these patients are typically coagulopathic and at risk for intracranial hemorrhage (ICH). Contemporary ICP monitoring techniques and coagulopathy reversal strategies may be associated with a lower risk of hemorrhage. Our objective was to evaluate the safety, feasibility, impact on clinical management and outcomes associated with protocol-directed use of IICPM in ALF...
July 11, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28692474/molecular-adsorbent-recirculating-system-effectively-replaces-hepatic-function-in-severe-acute-liver-failure
#15
Steven I Hanish, Deborah M Stein, Joseph R Scalea, Eno-Obong Essien, Paul Thurman, William R Hutson, Stephen T Bartlett, Rolf N Barth, Thomas M Scalea
BACKGROUND DATA: Patients with severe acute liver failure (ALF) have extreme physiologic dysfunction and often die if transplantation is not immediately available. Patients may be supported with MARS (Baxter International Inc., Deerfield, IL) until transplantation or spontaneous recovery occurs. We present the largest series in the United States of MARS therapy as temporary hepatic replacement for ALF. METHODS: MARS was used to support patients with severe liver trauma (SLT), in ALF patients as a bridge to transplantation (BTT), and as definitive therapy for toxic ingestion or idiopathic liver failure (DT) in a level 1 trauma center and large transplant center...
July 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28689811/ampk-activation-ameliorates-d-galn-lps-induced-acute-liver-failure-by-upregulating-foxo3a-to-induce-autophagy
#16
Yan-Min Liu, Jun Lv, Qing-Lei Zeng, Shen Shen, Ji-Yuan Xing, Ying-Ying Zhang, Zhi-Hao Zhang, Zu-Jiang Yu
BACKGROUND AND AIM: Acute liver failure (ALF) is an uncommon but serious disease still carrying a high mortality. This study aimed to investigate the mechanism of AMPK on D-GalN/LPS-induced ALF. METHODS: In this study, we utilized intraperitoneal injection of D-GalN/LPS to induce ALF model, and analyzed the expression of AMPK, inflammatory cytokines (TNF-α, IL-1β and IL-6), Foxo3A and autophagy-related genes (Atg-5, Beclin-1, Atg-7) by real-time quantitative polymerase chain reaction (RT-PCR) in liver tissue...
July 6, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28684799/modifications-of-pseudomonas-aeruginosa-cell-envelope-in-the-cystic-fibrosis-airway-alters-interactions-with-immune-cells
#17
Preston J Hill, Julia M Scordo, Jesús Arcos, Stephen E Kirkby, Mark D Wewers, Daniel J Wozniak, Jordi B Torrelles
Pseudomonas aeruginosa is a ubiquitous environmental organism and an opportunistic pathogen that causes chronic lung infections in the airways of cystic fibrosis (CF) patients as well as other immune-compromised individuals. During infection, P. aeruginosa enters the terminal bronchioles and alveoli and comes into contact with alveolar lining fluid (ALF), which contains homeostatic and antimicrobial hydrolytic activities, termed hydrolases. These hydrolases comprise an array of lipases, glycosidases, and proteases and thus, they have the potential to modify lipids, carbohydrates and proteins on the surface of invading microbes...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679953/anti-citrullinated-protein-antibodies-cause-arthritis-by-cross-reactivity-to-joint-cartilage
#18
Changrong Ge, Dongmei Tong, Bibo Liang, Erik Lönnblom, Nadine Schneider, Cecilia Hagert, Johan Viljanen, Burcu Ayoglu, Roma Stawikowska, Peter Nilsson, Gregg B Fields, Thomas Skogh, Alf Kastbom, Jan Kihlberg, Harald Burkhardt, Doreen Dobritzsch, Rikard Holmdahl
Today, it is known that autoimmune diseases start a long time before clinical symptoms appear. Anti-citrullinated protein antibodies (ACPAs) appear many years before the clinical onset of rheumatoid arthritis (RA). However, it is still unclear if and how ACPAs are arthritogenic. To better understand the molecular basis of pathogenicity of ACPAs, we investigated autoantibodies reactive against the C1 epitope of collagen type II (CII) and its citrullinated variants. We found that these antibodies are commonly occurring in RA...
July 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28679425/overexpression-of-c-met-in-bone-marrow-mesenchymal-stem-cells-improves-their-effectiveness-in-homing-and-repair-of-acute-liver-failure
#19
Kun Wang, Yuwen Li, Tiantian Zhu, Yongting Zhang, Wenting Li, Wenyu Lin, Jun Li, Chuanlong Zhu
BACKGROUND: Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has emerged as a novel therapy for acute liver failure (ALF). However, the homing efficiency of BMSCs to the injured liver sites appears to be poor. In this study, we aimed to determine if overexpression of c-Met in BMSCs could promote the homing ability of BMSCs to rat livers affected by ALF. METHODS: Overexpression of c-Met in BMSCs (c-Met-BMSCs) was attained by transfection of naive BMSCs with the lenti-c-Met-GFP...
July 5, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28672411/rates-of-upper-facet-joint-violation-in-minimally-invasive-percutaneous-and-open-instrumentation-a-comparative-cohort-study-of-different-insertion-techniques
#20
Eleftherios Archavlis, Nimer Amr, Sven Rainer Kantelhardt, Alf Giese
No abstract text is available yet for this article.
July 3, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
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