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https://www.readbyqxmd.com/read/28528830/eyelid-sebaceous-gland-carcinoma-with-extensive-pagetoid-spread
#1
Arpine Barsegian, Roman Shinder
No abstract text is available yet for this article.
June 2017: Ophthalmology
https://www.readbyqxmd.com/read/28525331/an-immunohistochemical-analysis-of-lymphocytic-infiltrations-in-canine-skin-cancers
#2
J A Madej, J P Madej, S Dzimira, M Nowak
Lymphocytic infiltrations located in the extracellular matrix often accompany canine skin cancer. They can be characterised as an inflammatory infiltration and/or a second tumour - lymphoma. The aim of this study was an immunohistochemical analysis of a lymphocytic infiltration which accompanies spontaneous skin cancer. Twenty basal cell carcinoma, 20 non-keratinizing squamous cell carcinoma, 20 keratinizing squamous cell carcinoma and 8 sebaceous gland carcinoma samples which were accompanied by a lymphocytic infiltration and/or secondary lymphatic follicles were verified histopathologically...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28507641/a-case-report-of-muir-torre-syndrome-in-a-woman-with-breast-cancer-and-msi-low-skin-squamous-cell-carcinoma
#3
Caroline Kientz, Marie-Odile Joly, Laurence Faivre, Alix Clemenson, Sophie Dalac, Côme Lepage, Caroline Chapusot, Caroline Jacquot, Renaud Schiappa, Marine Lebrun
BACKGROUND: The tumor spectrum in the Lynch syndrome is well defined, comprising an increased risk of developing colonic and extracolonic malignancies. Muir-Torre syndrome is a variant with a higher risk of skin disease. Patients have been described carrying mutations in the mismatch repair genes and presenting tumors with unusual histology or affected organ not part of the Lynch syndrome spectrum. Hence, the real link between Lynch syndrome, or Muir-Torre syndrome, and these tumors remains difficult to assess...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28448096/sebaceous-carcinomas-of-the-skin-24-cases-and-a-literature-review
#4
Roger Haber, Maxime Battistella, Cecile Pages, Martine Bagot, Celeste Lebbe, Nicole Basset-Seguin
No abstract text is available yet for this article.
April 27, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28445202/adnexal-carcinomas-treated-with-mohs-micrographic-surgery-a-comprehensive-review
#5
Stanislav N Tolkachjov
BACKGROUND: Adnexal carcinomas (ACs) are rare cutaneous malignancies of sweat gland or pilosebaceous origin. Optimal treatment and metastatic potential of AC are poorly defined. Mohs micrographic surgery (MMS) has been increasingly used to treat AC. OBJECTIVE: To review selected primary cutaneous AC and their treatment outcomes with MMS. MATERIALS AND METHODS: Literature review using PubMed search for articles related to primary cutaneous ACs...
April 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28412687/application-of-tegafur-gimer-docetaxel-and-carboplatin-in-head-and-neck-squamous-cell-carcinoma-therapy
#6
Baoqing Wang, Shiqiang Zhang, Qingping Xue, Yan Xie, Guiqin Ling, Ziquan Wang, Xinjun Chen
Squamous cell carcinoma, in the clinical manifestation, is a form of cancer derived from lesions of keratinocytes of epidermis or accessories such as sebaceous ducts, hair follicles, sweat glands, etc. The disease is more common in older men, with prone locations at patients' scalp, face, neck and arms and other exposed parts. Head and neck squamous cell carcinoma (HNSCC) causes a serious impact on patients' daily life, making patients suffer from double blow in mental and physical aspects and reducing patients' life quality...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28399340/what-s-new-in-eyelid-tumors
#7
Nora Silverman, Roman Shinder
Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Given the constraints of the anatomy and function of the eyelids, excision with negative margins and reconstruction can be challenging. In cases of significant tissue invasion or metastasis, complete tumor removal may not be possible...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28373462/expression-of-anti-apoptotic-protein-bag3-in-human-sebaceous-gland-carcinoma-of-the-eyelid
#8
Tatsuya Yunoki, Yoshiaki Tabuchi, Atsushi Hayashi
BACKGROUND: Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), has been shown to play a role in anti-apoptosis of various malignant tumors. In this study, the expression of BAG3 was examined in human sebaceous gland carcinoma of the eyelid. MATERIALS AND METHODS: The expression of BAG3 was evaluated by immunohistochemistry of surgical samples from 5 patients with sebaceous gland carcinoma in the eyelid. RESULTS: BAG3 was positive diffusely in the cytoplasm in all patients...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28350693/prognostic-value-of-the-staging-system-for-eyelid-tumors-in-the-7th-edition-of-the-american-joint-committee-on-cancer-staging-manual
#9
Joshua Ford, Sudip Thakar, Bradley Thuro, Bita Esmaeli
PURPOSE: To determine the prognostic value of the staging criteria for eyelid tumors in the 7th edition of the American Joint Committee on Cancer (AJCC) staging manual and to determine, for each type of eyelid tumor, which AJCC T categories are associated with increased risk of nodal metastasis and thus potential usefulness of sentinel lymph node biopsy. METHODS: Systematic review and analysis of articles found by searching PubMed and Google Scholar using the search terms "AJCC," "eyelid," "carcinoma," and "melanoma...
March 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28343197/-skin-cancers-in-kidney-transplant-recipients
#10
Anna Bieryło, Szymon Brzósko, Elżbieta Laudańska, Beata Naumnik
Kidney transplantation is the best treatment for end-stage renal failure. It prolongs the patient's life, improves quality of life and reduces costs associated with renal replacement therapy. Increasingly, newer immunosuppressive regimens allow for the proper functioning of the transplanted organ for many years. The progress in transplantation, qualification patients in older age for the procedure and longer survival of kidney graft lead to an increase in the number of patients receiving immunosuppressive drugs...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28323779/gata3-and-myb-expression-in-cutaneous-adnexal-neoplasms
#11
Joana Pardal, Uma Sundram, M Angelica Selim, Mai P Hoang
Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28323778/squared-off-nuclei-and-appliqu%C3%A3-pattern-as-a-histopathological-clue-to-periocular-sebaceous-carcinoma-a-clinicopathological-study-of-50-neoplasms-from-46-patients
#12
Sigrid M C Broekaert, Katharina Flux, Liubov Kyrpychova, Denisa Kacerovska, Doina Ivan, Michael P Schön, Philipp Ströbel, Michal Michal, Natalja Denisjuk, Katrin Kerl, Dmitry V Kazakov
The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28323777/msh6-past-and-present-and-muir-torre-syndrome-connecting-the-dots
#13
REVIEW
Meera Mahalingam
Sebaceous neoplasms such as adenoma, sebaceoma, and carcinoma, although sporadic in their occurrence, are clinically significant because of their association with Muir-Torre syndrome (MTS). MTS is a rare autosomal dominant genodermatosis characterized by the occurrence of sebaceous neoplasms and/or keratoacanthomas and visceral malignancies. MTS is usually the result of germline mutations in the DNA mismatch repair genes MSH2 and, albeit less commonly, MLH1. Although less know, MSH6 is yet another key player...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28321454/-colorectal-cancer-and-associated-sebaceous-gland-carcinoma-a%C3%A2-syndrome
#14
J Harms, B Kunzmann, T Reineke-Plaass, H H Kreipe, A Reinecke-Lüthge, R Czymek, T Jungbluth
No abstract text is available yet for this article.
March 20, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28300931/squamous-cell-carcinoma-arising-in-a-multiple-verrucous-epidermal-nevus
#15
Samira Yarak, Taila Yuri Siqueira Machado, Marilia Marufuji Ogawa, Mirian Luzia da Silva Almeida, Milvia Maria Simões E Silva Enokihara, Adriana Maria Porro
Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. We report a case of well-differentiated invasive squamous cell carcinoma arising from a multiple verrucous epidermal nevus. Although there is no consensus on prophylactic removal of epidermal nevus, its removal and biopsy should be considered if changes occur...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28300861/primary-cribriform-carcinoma-of-the-eyelid-with-neuroendocrine-features-a-case-report
#16
Joshua D Fox, Sander R Dubovy, Sara T Wester, Keyvan Nouri
A variety of tumors may involve the eyelid, most of which are primary, but rarely can be metastatic. Previously reported eyelid primary carcinomas with neuroendocrine features include Merkel cell carcinoma, apocrine and eccrine gland carcinoma, sebaceous gland carcinoma, and one report of primary "well-differentiated neuroendocrine tumor." Herein we report the first case of primary cribriform carcinoma of the eyelid with neuroendocrine features. The patient is a 75-year-old black man who presented to the clinic with a 5-year history of a slowly growing, non-painful, non-exudative lesion of his left lower eyelid...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28284233/retrospective-study-of-rare-cutaneous-malignant-adnexal-tumors-of-the-head-and-neck-in-a-tertiary-care-cancer-hospital-a-case-series
#17
Omer Waqas, Muhammad Faisal, Irfan Haider, Awais Amjad, Arif Jamshed, Raza Hussain
BACKGROUND: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease...
March 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28273971/clinico-pathological-spectrum-of-ophthalmic-lesions-an-experience-in-tertiary-care-hospital-of-central-india
#18
Yashita Gupta, Renuka Gahine, Nighat Hussain, Mohd Jafar Memon
INTRODUCTION: Ophthalmic lesions show varied distribution on the basis of geographical location. Eye being a unique sensory organ needs to be studied both clinically and pathologically. AIM: This study was aimed to evaluate the histomorphological and clinico-pathlological spectrum of ophthalmic lesions at a tertiary care hospital of Central India. MATERIALS AND METHODS: We reviewed all the ophthalmic biopsies performed in the Department of Pathology of our institute between January 2008 and November 2014...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28256768/topics-in-histopathology-of-sweat-gland-and-sebaceous-neoplasms
#19
REVIEW
Shin-Ichi Ansai
This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117 can help to distinguish sweat gland or sebaceous tumors from other non-Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of antibodies may be useful, including p63 (SGC(+) , SMBC(-) ), CK5/6 (SGC(+) , SMBC(-) ), podoplanin (SGC(+) , SMBC(-) ) and mammaglobin (SGC(-) , SMBC(+) )...
March 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28221180/sebaceous-carcinoma-arising-within-a-nevus-sebaceus-excised-by-mohs-micrographic-surgery
#20
Wesley Wu, Gunjan M Modi, Mohsin R Mir, Divya Srivastava
No abstract text is available yet for this article.
February 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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