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https://www.readbyqxmd.com/read/28098399/myb-cd117-and-sox-10-expression-in-cutaneous-adnexal-tumors
#1
Mara Therese P Evangelista, Jeffrey P North
BACKGROUND: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117, and SOX-10 expression in cutaneous adnexal tumors. METHODS: Retrospective analysis of 184 benign adnexal tumors (140 eccrine/apocrine, 40 follicular, and 10 sebaceous), and 30 malignant adnexal tumors was performed with MYB, SOX-10, and CD117 immunostaining...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28097371/high-resolution-diffusion-weighted-imaging-for-solitary-orbital-tumors-3d-turbo-field-echo-with-diffusion-sensitized-driven-equilibrium-dsde-tfe-preparation-technique
#2
Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Hiroshi Yoshikawa, Makoto Obara, Hiroshi Honda
PURPOSE: To differentiate cystic from solid solitary intraorbital tumors using 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation without contrast material. MATERIALS AND METHODS: This retrospective study was approved by our institutional review boards, and written informed consent was waived. A total of 26 patients with intraorbital tumors were studied. Motion probing gradients were conducted at one direction with b‑values of 0 and 500 s/mm(2)...
January 17, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28070642/distinct-expression-profile-of-stem-cell-markers-lgr5-and-lgr6-in-basaloid-skin-tumors
#3
Bo Gun Jang, Cheol Lee, Hye Sung Kim, Myung Soo Shin, Min Seok Cheon, Jae Wang Kim, Woo Ho Kim
Mammalian epidermis, which is composed of hair follicles, sebaceous glands, and interfollicular epidermis, is maintained by discrete stem cells. In vivo lineage tracing demonstrated that murine LGR5 cells are mainly responsible for hair follicle regeneration whereas LGR6 cells generate sebaceous glands and interfollicular epidermis. However, little is known about their expression in the human skin tumors. In this study, we investigated the expression profile of LGR5 and LGR6 in a variety of human skin tumors including basaloid tumors with follicular differentiation (94 basal cell carcinomas, 18 trichoepitheliomas, 3 basaloid follicular hamartomas, and 12 pilomatricomas) and tumors with ductal differentiation (7 eccrine poromas, 8 hidradenomas, and 5 spiradenomas)...
January 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28027254/evidence-based-medicine-cutaneous-facial-malignancies-nonmelanoma-skin-cancer
#4
Karen L Connolly, Kishwer S Nehal, Joseph J Disa
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Define appropriate management based on current guidelines for various types of basal cell and squamous cell carcinoma. SUMMARY: Skin malignancies are the most prevalent cancers, and plastic surgeons are often the primary physicians engaged in diagnosis and management of these lesions...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28027201/incidence-and-clinical-features-of-rare-cutaneous-malignancies-in-olmsted-county-minnesota-2000-to-2010
#5
Stanislav N Tolkachjov, Adam R Schmitt, John G Muzic, Amy L Weaver, Christian L Baum
BACKGROUND: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data. OBJECTIVE: To determine the incidence of several rare nonmelanoma skin cancers. MATERIALS AND METHODS: The authors conducted a retrospective chart review of a population-based cohort between the years 2000 and 2010. Residents of Olmsted County, Minnesota, who were diagnosed with a biopsy-proven nonmelanoma skin cancer-excluding basal cell carcinoma and squamous cell carcinoma-were included in this study...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28027080/carcinoid-like-labyrinthine-pattern-in-sebaceous-neoplasms-represents-a-sebaceous-mantle-phenotype-immunohistochemical-analysis-of-aberrant-vimentin-expression-and-cytokeratin-20-positive-merkel-cell-distribution
#6
Keisuke Goto, Takashi Anan, Takaya Fukumoto, Tetsunori Kimura, Noriyuki Misago
This study investigated the nature of carcinoid-like, labyrinthine, rippled, and conventional cell arrangements in sebaceous neoplasms, focusing on vimentin expression and Merkel cell distribution in sebaceous neoplasms relative to these findings in normal sebaceous units and other sebaceous conditions. Immunohistochemistry for vimentin and cytokeratin 20 (CK20) was evaluated in carcinoid-like (n = 2), labyrinthine (n = 4), rippled (n = 3), and conventional (n = 6) sebaceomas; sebaceous mantle hyperplasia (n = 1); steatocystomas (n = 5); fibrofolliculomas (n = 4); sebaceous mantleoma (n = 1); sebaceous gland hyperplasias (n = 4); sebaceous adenomas (n = 4); and sebaceous carcinomas (n = 4) as well as normal skin tissue...
December 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27976423/mohs-micrographic-surgery-of-rare-cutaneous-tumors
#7
Sophie C Flohil, Charlotte B van Lee, Jessica Beisenherz, Marc A M Mureau, Lucy I H Overbeek, Tamar Nijsten, Renate R van den Bos
BACKGROUND: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumors are poorly defined. OBJECTIVE: Investigate the recurrence rate after MMS for rare cutaneous tumors at a university center. METHODS & MATERIALS: Retrospective review of all rare cutaneous tumors treated with MMS at a large university center between January 2008 and December 2012. To detect all recurrences, patients were linked to The nationwide network and registry of histo- and cytopathology (PALGA)...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27919252/neoplastic-diseases-in-the-domestic-ferret-mustela-putorius-furo-in-italy-classification-and-tissue-distribution-of-856-cases-2000-2010
#8
Giancarlo Avallone, Annalisa Forlani, Marco Tecilla, Elena Riccardi, Sara Belluco, Sara Francesca Santagostino, Guido Grilli, Kiumars Khadivi, Paola Roccabianca
BACKGROUND: The aim of this study was to describe the prevalence and tissue distribution of neoplasms in Italian ferrets, compared to the epidemiological data previously reported in USA and Japan. METHODS: Signalment and diagnoses of pathological submissions received between 2000 and 2010 were searched; cases with the diagnosis of neoplasm were selected and original sections reviewed to confirm the diagnosis. RESULTS: Nine-hundred and ten samples were retrieved, 690 of which included at least one tumour for a total of 856 tumours...
December 5, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27878368/-therapy-options-for-malignant-eyelid-tumors
#9
M Weiling, A Bergua, F E Kruse, L Holbach
Basal cell carcinomas are the most common malignant tumors of the eyelids. Patient history, clinical symptoms and signs, inspection, palpation and slit-lamp examination usually allow a working diagnosis; however, the clinical diagnosis requires histopathological confirmation and determination of the histopathological type. Squamous cell carcinomas, sebaceous gland carcinomas, melanomas and Merkel cell carcinomas can metastasize usually via the lymph vessels into the regional lymph nodes. Microscopically controlled excision of the primary tumor into healthy tissue is most commonly the first goal...
December 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27870730/cutaneous-sebaceous-lesions-in-a-patient-with-mutyh-associated-polyposis-mimicking-muir-torre-syndrome
#10
Denisa Kacerovska, Lubomir Drlik, Lenka Slezakova, Michal Michal, Jan Stehlik, Monika Sedivcova, Ladislav Hadravsky, Dmitry V Kazakov
A 76-year-old white male with a history of adenocarcinoma of the rectosigmoideum and multiple colonic polyps removed at the age of 38 and 39 years by an abdominoperitoneal amputation and total colectomy, respectively, presented with multiple whitish and yellowish papules on the face and a verrucous lesion on the trunk. The lesions were surgically removed during the next 3 years and a total of 13 lesions were investigated histologically. The diagnoses included 11 sebaceous adenomas, 1 low-grade sebaceous carcinoma, and 1 squamous cell carcinoma...
December 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27844049/sebaceous-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#11
Stephanie A Sullivan, Arthur-Quan Tran, Siobhan O'Connor, Paola A Gehrig
•Sebaceous carcinoma (SC) is rare with only nine cases reported in the literature.•Extraocular SC likely has similar prognosis to ocular SC.•Reporting of vulvar SC should include detailed pathologic information so that risk factor associations can be made.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27843279/unusual-presentation-of-ulcerative-postauricular-swelling-as-sebaceous-cell-carcinoma
#12
Prem Chand, Ashok Kumar, Paramjit Singh, Lakshay Singla
Sebaceous glands have high concentration over head and neck region. Despite high concentration, sebaceous cell adenoma and carcinomas are infrequent. Sebaceous cell carcinoma is an uncommon, cutaneous aggressive tumor arising from the sebaceous glands and seen almost exclusively on the eyelids (75%). It accounts for just 0.2-0.7% of all eyelid tumors in the USA and very few cases that have originated in areas other than the eyelids have been reported. A 67-year-old male presented with swelling (3 cm × 4 cm), on the right postauricular region, since about 1-month...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27832425/histopathologic-pitfalls-of-mohs-micrographic-surgery-and-a%C3%A2-review-of-tumor-histology
#13
REVIEW
Katlein França, Yasser Alqubaisy, Ashraf Hassanein, Keyvan Nouri, Torello Lotti
Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Frozen sections introduce certain artifacts and these artifacts must be interpreted in the correct context. Basal and squamous cell carcinomas are the most common tumors encountered in Mohs micrographic surgery, and their histopathology is also associated with certain "pitfalls"...
November 10, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27811637/cutaneous-horn-of-the-eyelid-in-13-cases
#14
Renelle Pointdujour-Lim, Molly R Marous, Celine E Satija, Alexzandra M Douglass, Ralph C Eagle, Jerry A Shields, Carol L Shields
INTRODUCTION: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid. OBJECTIVE: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. DESIGN: A retrospective analysis of 13 cases of cutaneous horn of the eyelid treated between 1994 and 2014 was performed. PARTICIPANTS: Thirteen patients participated in this study...
November 2, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27773155/a-case-report-of-invasive-ductal-carcinoma-of-the-breast-with-prominent-sebaceous-differentiation
#15
Annalisa Solinas, Catriona McKenzie, Sandra O'Toole, Sanjay Warrier, Cindy Mak
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27771121/-muir-torre-syndrome-associated-with-waldenstrom-s-macroglobulinemia
#16
C Velter, F Bourlond, C Wettle, B Lioure, D Lipsker, C Maugard, B Cribier
BACKGROUND: Muir-Torre syndrome (MTS), a cutaneous variant of Lynch syndrome, consists of hereditary predisposition to cutaneous tumours and gastrointestinal and gynaecological neoplasms, with autosomal dominant transmission. It is associated with mutations in genes coding for proteins in the DNA mismatch repair system. PATIENTS AND METHODS: Herein, we report a case of a male patient presenting Waldenstrom's macroglobulinemia since the age of 50 and which, after the age of 65 years, developed into sebaceous tumours (5 sebaceous adenomas, 1 sebaceoma, 1 sebaceous carcinoma) and colonic lesions (4 adenomas)...
December 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27768120/orbital-exenteration-for-advanced-periorbital-non-melanoma-skin-cancer-prognostic-factors-and-survival
#17
R C Gerring, C T Ott, J M Curry, Z B Sargi, S T Wester
PurposeTo describe prognostic factors and survival outcomes in patients who underwent orbital exenteration for periocular non-melanoma cutaneous malignancies.MethodsThe authors performed an institutional review board-approved retrospective review of all patients who underwent orbital exenteration for non-melanoma periocular cutaneous malignancies at a tertiary care hospital system over a 10-year period. Patient demographics, tumor, and treatment data were recorded. Survival outcomes included disease-free survival (DFS) and overall survival (OS)...
October 21, 2016: Eye
https://www.readbyqxmd.com/read/27763901/extraocular-sebaceous-carcinoma-a-clinicopathologic-reassessment
#18
Nicole M Candelario, Julio E Sánchez, Jorge L Sánchez, Rafael F Martín-García, Nicole M Rochet
Sebaceous carcinoma is an aggressive adnexal neoplasm with sebaceous differentiation. Few reports have described the histopathologic characteristics of the sebaceous carcinoma occurring extraocularly. Seventy-two cases of extraocular sebaceous carcinoma were identified from the database of a Dermatopathology Laboratory from January 1, 2007 to May 31, 2013. More cases occurred in men (60%), with a mean age at diagnosis of 65.8 years (range 39-99 years). Neoplasms were histopathologically classified as well-differentiated (22%), moderately differentiated (67%), and poorly differentiated (11%)...
November 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27761094/syringocystadenoma-papilliferum-of-the-scalp-arising-from-a-nevus-sebaceous
#19
Mathangi Chandramouli, Digvijay Sarma, Kapil Tejaswy, Gabriel Rodrigues
Syringocystadenoma papilliferum (SCAP) is a rare, benign tumour with varied presentations that arises from the apocrine glands and at times can lead to a diagnostic dilemma. A 53-year-old male presented with a 40-year history of a scalp nodule and a recent 2-year change in its character, and a sanguinopurulent discharge. Examination revealed a 4 cm × 2 cm firm nodule upon left side of the scalp vertex, actively discharging pus and blood. No regional lymph nodes were noticeably palpable. Incision biopsy performed elsewhere showed evidence of a squamous cell carcinoma-in-situ...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27752212/perineural-spread-in-squamous-cell-carcinoma-of-the-face-an-overlooked-facet-of-information-on-imaging
#20
Venkatraman Bhat, Jenna Devere, Athira Ramakrishanan, Moni A Kuriakose
A case of malignant cutaneous lesion of the face diagnosed initially as sebaceous carcinoma, subsequently proven to be squamous cell carcinoma is presented. Patient was initially evaluated at an outside institution by computed tomography, which indicated extension of lesion to the maxillary sinus. Patient underwent local resection. Further imaging by magnetic resonance imaging was done for recurrent tumour. Examination revealed extensive, large volume, perineural extension of the disease via infraorbital nerve to the cavernous sinus...
September 2016: Journal of Maxillofacial and Oral Surgery
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