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https://www.readbyqxmd.com/read/27878368/-therapy-options-for-malignant-eyelid-tumors
#1
M Weiling, A Bergua, F E Kruse, L Holbach
Basal cell carcinomas are the most common malignant tumors of the eyelids. Patient history, clinical symptoms and signs, inspection, palpation and slit-lamp examination usually allow a working diagnosis; however, the clinical diagnosis requires histopathological confirmation and determination of the histopathological type. Squamous cell carcinomas, sebaceous gland carcinomas, melanomas and Merkel cell carcinomas can metastasize usually via the lymph vessels into the regional lymph nodes. Microscopically controlled excision of the primary tumor into healthy tissue is most commonly the first goal...
November 22, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27870730/cutaneous-sebaceous-lesions-in-a-patient-with-mutyh-associated-polyposis-mimicking-muir-torre-syndrome
#2
Denisa Kacerovska, Lubomir Drlik, Lenka Slezakova, Michal Michal, Jan Stehlik, Monika Sedivcova, Ladislav Hadravsky, Dmitry V Kazakov
A 76-year-old white male with a history of adenocarcinoma of the rectosigmoideum and multiple colonic polyps removed at the age of 38 and 39 years by an abdominoperitoneal amputation and total colectomy, respectively, presented with multiple whitish and yellowish papules on the face and a verrucous lesion on the trunk. The lesions were surgically removed during the next 3 years and a total of 13 lesions were investigated histologically. The diagnoses included 11 sebaceous adenomas, 1 low-grade sebaceous carcinoma, and 1 squamous cell carcinoma...
December 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27844049/sebaceous-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#3
Stephanie A Sullivan, Arthur-Quan Tran, Siobhan O'Connor, Paola A Gehrig
•Sebaceous carcinoma (SC) is rare with only nine cases reported in the literature.•Extraocular SC likely has similar prognosis to ocular SC.•Reporting of vulvar SC should include detailed pathologic information so that risk factor associations can be made.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27843279/unusual-presentation-of-ulcerative-postauricular-swelling-as-sebaceous-cell-carcinoma
#4
Prem Chand, Ashok Kumar, Paramjit Singh, Lakshay Singla
Sebaceous glands have high concentration over head and neck region. Despite high concentration, sebaceous cell adenoma and carcinomas are infrequent. Sebaceous cell carcinoma is an uncommon, cutaneous aggressive tumor arising from the sebaceous glands and seen almost exclusively on the eyelids (75%). It accounts for just 0.2-0.7% of all eyelid tumors in the USA and very few cases that have originated in areas other than the eyelids have been reported. A 67-year-old male presented with swelling (3 cm × 4 cm), on the right postauricular region, since about 1-month...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27832425/histopathologic-pitfalls-of-mohs-micrographic-surgery-and-a%C3%A2-review-of-tumor-histology
#5
REVIEW
Katlein França, Yasser Alqubaisy, Ashraf Hassanein, Keyvan Nouri, Torello Lotti
Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Frozen sections introduce certain artifacts and these artifacts must be interpreted in the correct context. Basal and squamous cell carcinomas are the most common tumors encountered in Mohs micrographic surgery, and their histopathology is also associated with certain "pitfalls"...
November 10, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27811637/cutaneous-horn-of-the-eyelid-in-13-cases
#6
Renelle Pointdujour-Lim, Molly R Marous, Celine E Satija, Alexzandra M Douglass, Ralph C Eagle, Jerry A Shields, Carol L Shields
INTRODUCTION: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid. OBJECTIVE: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. DESIGN: A retrospective analysis of 13 cases of cutaneous horn of the eyelid treated between 1994 and 2014 was performed. PARTICIPANTS: Thirteen patients participated in this study...
November 2, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27773155/a-case-report-of-invasive-ductal-carcinoma-of-the-breast-with-prominent-sebaceous-differentiation
#7
Annalisa Solinas, Catriona McKenzie, Sandra O'Toole, Sanjay Warrier, Cindy Mak
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27771121/-muir-torre-syndrome-associated-with-waldenstrom-s-macroglobulinemia
#8
C Velter, F Bourlond, C Wettle, B Lioure, D Lipsker, C Maugard, B Cribier
BACKGROUND: Muir-Torre syndrome (MTS), a cutaneous variant of Lynch syndrome, consists of hereditary predisposition to cutaneous tumours and gastrointestinal and gynaecological neoplasms, with autosomal dominant transmission. It is associated with mutations in genes coding for proteins in the DNA mismatch repair system. PATIENTS AND METHODS: Herein, we report a case of a male patient presenting Waldenstrom's macroglobulinemia since the age of 50 and which, after the age of 65 years, developed into sebaceous tumours (5 sebaceous adenomas, 1 sebaceoma, 1 sebaceous carcinoma) and colonic lesions (4 adenomas)...
October 19, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27768120/orbital-exenteration-for-advanced-periorbital-non-melanoma-skin-cancer-prognostic-factors-and-survival
#9
R C Gerring, C T Ott, J M Curry, Z B Sargi, S T Wester
PurposeTo describe prognostic factors and survival outcomes in patients who underwent orbital exenteration for periocular non-melanoma cutaneous malignancies.MethodsThe authors performed an institutional review board-approved retrospective review of all patients who underwent orbital exenteration for non-melanoma periocular cutaneous malignancies at a tertiary care hospital system over a 10-year period. Patient demographics, tumor, and treatment data were recorded. Survival outcomes included disease-free survival (DFS) and overall survival (OS)...
October 21, 2016: Eye
https://www.readbyqxmd.com/read/27763901/extraocular-sebaceous-carcinoma-a-clinicopathologic-reassessment
#10
Nicole M Candelario, Julio E Sánchez, Jorge L Sánchez, Rafael F Martín-García, Nicole M Rochet
Sebaceous carcinoma is an aggressive adnexal neoplasm with sebaceous differentiation. Few reports have described the histopathologic characteristics of the sebaceous carcinoma occurring extraocularly. Seventy-two cases of extraocular sebaceous carcinoma were identified from the database of a Dermatopathology Laboratory from January 1, 2007 to May 31, 2013. More cases occurred in men (60%), with a mean age at diagnosis of 65.8 years (range 39-99 years). Neoplasms were histopathologically classified as well-differentiated (22%), moderately differentiated (67%), and poorly differentiated (11%)...
November 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27761094/syringocystadenoma-papilliferum-of-the-scalp-arising-from-a-nevus-sebaceous
#11
Mathangi Chandramouli, Digvijay Sarma, Kapil Tejaswy, Gabriel Rodrigues
Syringocystadenoma papilliferum (SCAP) is a rare, benign tumour with varied presentations that arises from the apocrine glands and at times can lead to a diagnostic dilemma. A 53-year-old male presented with a 40-year history of a scalp nodule and a recent 2-year change in its character, and a sanguinopurulent discharge. Examination revealed a 4 cm × 2 cm firm nodule upon left side of the scalp vertex, actively discharging pus and blood. No regional lymph nodes were noticeably palpable. Incision biopsy performed elsewhere showed evidence of a squamous cell carcinoma-in-situ...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27752212/perineural-spread-in-squamous-cell-carcinoma-of-the-face-an-overlooked-facet-of-information-on-imaging
#12
Venkatraman Bhat, Jenna Devere, Athira Ramakrishanan, Moni A Kuriakose
A case of malignant cutaneous lesion of the face diagnosed initially as sebaceous carcinoma, subsequently proven to be squamous cell carcinoma is presented. Patient was initially evaluated at an outside institution by computed tomography, which indicated extension of lesion to the maxillary sinus. Patient underwent local resection. Further imaging by magnetic resonance imaging was done for recurrent tumour. Examination revealed extensive, large volume, perineural extension of the disease via infraorbital nerve to the cavernous sinus...
September 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27751525/-trichoblastoma-and-superficial-basal-cell-carcinoma-arising-in-naevus-sebaceous
#13
L Gouillon, L Thomas, S Dalle
No abstract text is available yet for this article.
October 14, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27720512/incidence-and-survival-of-sebaceous-carcinoma-in-the-united-states
#14
Raghav Tripathi, Zhengyi Chen, Li Li, Jeremy S Bordeaux
BACKGROUND: Information on risk factors, epidemiology, and clinical characteristics of sebaceous carcinoma (SC) is limited. OBJECTIVE: We sought to analyze trends in SC in the United States from 2000 through 2012. METHODS: We used data from the 18 registries of the Surveillance, Epidemiology, and End Results (SEER) Program from 2000 to 2012 to calculate the cause of death, relative frequencies/incidences, 5-/10-year Kaplan-Meier survival, hazard ratios, and incidence rates for SC...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27679547/metastatic-sebaceous-cell-carcinoma-review-of-the-literature-and-use-of-electrochemotherapy-as-possible-new-treatment-modality
#15
Simone Ribero, Eugenio Sportoletti Baduel, Matteo Brizio, Franco Picciotto, Emi Dika, Maria Teresa Fierro, Giuseppe Macripò, Pietro Quaglino
BACKGROUND: Metastatic extraorbital sebaceous carcinoma is a rare event that could involve the head and neck. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. MATERIAL AND METHODS: Extensive literature search was done, and the treatment options are discussed. RESULTS: Results. The literature search found several treatment modalities in use for the treatment of metastatic extraorbital sebaceous carcinoma...
September 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27631512/proposal-of-a-provisional-classification-of-sebaceous-carcinoma-based-on-hormone-receptor-expression-and-her2-status
#16
Hee Young Na, Ji-Young Choe, Seon Ah Shin, Ho-Kyung Choung, Sohee Oh, Jin-Haeng Chung, Mira Park, Ji Eun Kim
Despite recent progress in comprehensive genetic analysis, little is known about the molecular pathogenesis of sebaceous carcinoma. On the basis of the ontogenic proximity of sebaceous and mammary glands, we designed an intrinsic classification for sebaceous carcinoma adapted from that of breast cancer and evaluated its clinical significance. We investigated 42 cases of sebaceous carcinoma, including 32 ocular and 10 extraocular cases. Immunohistochemical analyses for estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), HER2, Ki67, and CK5/6 and fluorescence in situ hybridization for the HER2 gene were performed...
September 14, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27590119/risk-factors-for-local-recurrence-or-metastasis-of-eyelid-sebaceous-gland-carcinoma-after-wide-excision-with-paraffin-section-control
#17
Yasuhiro Takahashi, Emiko Takahashi, Shunsuke Nakakura, Yoshiyuki Kitaguchi, Jacqueline Mupas-Uy, Hirohiko Kakizaki
PURPOSE: To identify risk factors for local recurrence and metastasis of sebaceous gland carcinoma (SGC) after wide excision with paraffin section control. DESIGN: Retrospective, observational, case-control study. METHODS: Setting: Single institution. PATIENT POPULATION: Thirty-four patients with SGC who had undergone excision with 5-mm surgical margins and paraffin section pathological analysis. Observational Procedures: The following were considered potential risk factors for local recurrence/metastasis of SGC: patient's sex, patient's age, initial diagnosis at other clinics, topical treatments at other clinics, interval between appearance of symptoms to referral to our institution, tumor location, tumor origin, tumor presentation pattern, T category, tumor size, presence/or absence of pagetoid spread, tumor differentiation, mitosis grade, growth pattern...
August 30, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27510024/radiation-therapy-for-primary-eyelid-cancers-in-tunisia
#18
A Belaid, C Nasr, M Benna, A Cherif, O Jmour, H Bouguila, F Benna
Management of eyelid cancers is based on surgery and/or radiotherapy (RT). The treatment objective is to control tumors with acceptable functional and esthetic outcomes. The aim of this study was to evaluate the results of radiation therapy in management of epithelial eyelid cancers, reviewing retrospectively the clinical records of patients treated in our institution from January 1989 to December 2013. We focused on clinical and histological features, treatment characteristics, tolerance and disease control...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27506854/the-role-of-dog1-immunohistochemistry-in-dermatopathology
#19
Keisuke Goto
BACKGROUND: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors. METHODS: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues. RESULTS: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum...
August 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27504445/lrig1-expression-in-human-sebaceous-gland-tumors
#20
Jöri Pünchera, Laurent Barnes, Gürkan Kaya
BACKGROUND: Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. In this study, we analyzed the Lrig1 expression in human sebaceous tumors. METHODS: Twenty-eight formalin-fixed paraffin-embedded sebaceous tumor specimens (7 sebaceous hyperplasias, 7 sebaceous adenomas, 10 sebaceomas and 4 sebaceous carcinomas) were stained with anti-Lrig1, anti-CD44v3 and anti-Ki67 antibody...
April 2016: Dermatopathology (Basel, Switzerland)
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