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sebaceous carcinoma

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https://www.readbyqxmd.com/read/29436004/homeobox-transcriptional-factor-engrailed-homeobox-1-is-specifically-expressed-in-normal-and-neoplastic-sweat-gland-cells
#1
Keiko Miura, Takumi Akashi, Noboru Ando, Shinya Ayabe, Kou Kayamori, Takeshi Namiki, Yoshinobu Eishi
AIM: A number of homeobox transcriptional factors are utilized as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is specifically expressed in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms. METHODS AND RESULTS: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be specifically expressed in the skin...
February 12, 2018: Histopathology
https://www.readbyqxmd.com/read/29431200/gata-3-staining-in-primary-cutaneous-apocrine-cribriform-carcinoma-usefulness-to-differentiate-it-from-breast-cancer-metastasis
#2
M Llamas-Velasco, Y C Pérez-Gónzalez, E Daudén, A Rütten
BACKGROUND: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raise a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. DESIGN: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test this immunostaining usefulness to differentiate this tumor from metastatic breast cancer...
February 12, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29423837/analysis-of-hedgehog-signaling-in-periocular-sebaceous-carcinoma
#3
John C Bladen, Mariya Moosajee, Dhani Tracey-White, Michèle Beaconsfield, Edel A O'Toole, Michael P Philpott
PURPOSE: Sebaceous carcinoma (SC) is a clinical masquerader of benign conditions resulting in significant eye morbidity, sometimes leading to extensive surgical treatment including exenteration, and even mortality. Little is known about the genetic or molecular basis of SC. This study identifies the involvement of Hedgehog (Hh) signaling in periocular SC. METHODS: Fifteen patients with periocular SC patients were compared to 15 patients with eyelid nodular basal cell carcinoma (nBCC; a known Hh tumor), alongside four normal individuals as a control for physiological Hh expression...
February 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29364442/rare-desmoplastic-trichilemmoma-associated-with-sebaceous-nevus
#4
Márcio Martins Lobo Jardim, Bruno de Castro E Souza, Renata Cavanellas Fraga, Rafael Cavanellas Fraga
Nevus sebaceous of Jadassohn is a congenital hamartoma that usually affects the scalp and face. Several benign or malignant neoplasias may develop in the lesion and the most common are trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma. Trichilemmoma is a benign solid tumor originating from external sheath cells of pilosebaceous follicles. When it is characterized by a central zone of desmoplasia, it is called desmoplastic trichilemmoma. We report a case of a 58-year-old patient who developed a tumor in a sebaceous nevus...
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29352496/microcystic-adnexal-carcinoma-with-sebaceous-differentiation-three-cases
#5
Angel Fernandez-Flores, Mar Llamas-Velasco, Carles Saus, Anisha Patel, Arno Rutten
Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful...
January 20, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29329503/chemical-imaging-of-aggressive-basal-cell-carcinoma-using-time-of-flight-secondary-ion-mass-spectrometry
#6
Marwa Munem, Oscar Zaar, Kelly Dimovska Nilsson, Noora Neittaanmäki, John Paoli, John S Fletcher
A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface...
January 12, 2018: Biointerphases
https://www.readbyqxmd.com/read/29314288/the-limitations-of-dermoscopy-false-positive-and-false-negative-tumors
#7
REVIEW
V Papageorgiou, Z Apalla, E Sotiriou, C Papageorgiou, E Lazaridou, S Vakirlis, D Ioannides, A Lallas
Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumors, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically "false positive" and "false negative" tumors do exist. False positive diagnosis usually leads to unnecessary excisions. False negative diagnosis is much more dangerous, since it might result in overlooking a cancer, with severe undesirable consequences for the patient and the physician. Therefore, management strategies should mainly focus on addressing the risk of dermoscopically false negative tumors...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29310408/case-report-repairing-orbital-skin-defects-using-composite-flaps-after-giant-eyelid-derived-tumor-excision-and-orbital-exenteration
#8
Bin Fan, Jian-Ju Liu, Bei-Fen Wang, Ying-Jian Sun, Guang-Yu Li
RATIONALE: Though giant malignant tumors arising in the eyelid are rare, they often require extensive surgery for removal along with orbital exenteration. Because of this, repairing orbital defects is an important factor in the surgical strategy. PATIENT CONCERNS: Case 1 was a 78-year-old nomad man who presented in the Department of Ophthalmology with a giant tumor in his right eyelid, which had developed over three years. Clinical examination revealed a huge pigmented, nonhealing ulcerated lesion, approximately 52×44×40 mm in size...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29287845/sebaceous-carcinoma-mimicking-a-chalazion-in-a-young-patient
#9
C Fuente García, I Pinilla-Pagnon, A Albandea Jiménez, M Sales-Sanz
No abstract text is available yet for this article.
December 26, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29235655/dermoscopic-features-distinctive-for-extraocular-sebaceous-carcinoma
#10
Kohei Horimoto, Junji Kato, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Sayuri Sato, Hitomi Takahashi, Masahide Sawada, Toshiharu Yamashita, Hisashi Uhara
We examined dermoscopic features of three cases of extraocular sebaceous carcinoma and reviewed the literatures. The yellowish structures, polymorphous vessels and ulceration were common findings in our cases and all cases of the previous reports. The appearance of whitish-pink areas has not been described previously. Our results suggested that the combination of four dermoscopic features, whitish-pink areas, yellowish structures, polymorphous vessels and ulceration might be distinctive in extraocular sebaceous carcinoma...
December 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29177692/dermatological-complications-after-solid-organ-transplantation
#11
REVIEW
Luigi Naldi, Anna Venturuzzo, Pietro Invernizzi
Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e...
November 25, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29133634/immunohistochemical-expression-of-x-linked-inhibitor-of-apoptosis-in-eyelid-sebaceous-gland-carcinoma-predicts-a-worse-prognosis
#12
Perumal Jayaraj, Seema Sen, P S Dhanaraj, Romika Jhajhria, Shalu Singh, Vijay Kumar Singh
PURPOSE: Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers. X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of apoptosis which prevents apoptosis by inhibiting caspases 9, 7, and 3. The prognostic value of XIAP in sebaceous gland carcinoma (SGC) remains unexplored. METHODS: The immunohistochemical expression of XIAP was evaluated in 29 SGC cases...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29128599/cutaneous-metastasis-of-renal-cell-carcinoma-masquerading-as-an-infected-sebaceous-cyst
#13
R J Boaz, T Vig, A J Tirkey, N T John, R M Kumar, N Kekre
Renal cell carcinoma (RCC) is the third most common genitourinary malignancy with an estimated one third of cases with metastatic disease at the time of diagnosis. Though rare, cutaneous metastasis from RCC is more frequent than any other genitourinary malignancy. Metastasis of RCC to skin carries poor prognosis as coexistent visceral spread is the norm. A 38-year-old man presented one year after radical nephrectomy for clear cell carcinoma of the left kidney with a submental lesion that proved to be metastatic...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29093237/basal-cell-carcinoma-of-vermilion-mucosa-of-upper-lip-a-rare-case-report
#14
Reza Yaghoobi, Nastaran Ranjbari, Nader Pazyar, Maryam Foroozan, Amir Feily
Although basal cell carcinoma (BCC) is a common skin tumor, very rare cases of BCC arising from upper vermilion mucosa of lip have been reported previously. This tumor basically, originates from pillar structures and the involvement of the vermilion lip contrasts this concept so it is devoid of hair follicles and sweat glands. The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa and epidermis...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29078997/sebaceous-lesions-of-the-skin
#15
REVIEW
Jean Iacobelli, Nathan Tobias Harvey, Benjamin Andrew Wood
Sebaceous differentiation is commonly seen in cutaneous neoplasms, both in the context of lesions showing predominantly sebaceous differentiation (e.g., sebaceous adenoma, sebaceoma and sebaceous carcinoma), or as more focal sebaceous components in neoplasms with other primary lines of differentiation. Sebaceous changes can also be a component of benign cystic lesions or epidermal tumours, and sebaceous hyperplasia is commonly encountered. This review is intended to provide an overview of the cutaneous lesions with sebaceous differentiation, with a particular emphasis on facilitating histological diagnosis of neoplasms...
October 24, 2017: Pathology
https://www.readbyqxmd.com/read/29072946/histologic-mimics-of-basal-cell-carcinoma
#16
REVIEW
Lauren M Stanoszek, Grace Y Wang, Paul W Harms
CONTEXT: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma...
November 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29053046/microcystic-adnexal-carcinoma-of-the-orbit-mimicking-pagetoid-sebaceous-gland-carcinoma
#17
Bipasha Mukherjee, Nirmala Subramaniam, Krishna Kumar, Pratheeba Devi Nivean
Microcystic adnexal carcinoma (MAC) is a rare malignancy of sweat glands that has been reported most often on the face in the form of a cutaneous lesion, with the potential for deeper invasion. The synonyms of MAC include sclerosing sweat duct carcinoma, syringomatous carcinoma, and malignant syringoma. Clinically, MAC in the periocular area has been misdiagnosed as basal cell carcinoma, squamous cell carcinoma, or even chalazia. We report a case of MAC presenting clinically as sebaceous gland carcinoma with pagetoid spread for the first time in literature...
October 20, 2017: Orbit
https://www.readbyqxmd.com/read/29034129/sebaceous-carcinoma-in-situ-as-a-concept-and-diagnostic-entity
#18
Miglena K Komforti, Masoud Asgari, Sheng Chen
Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous carcinoma in situ has not been recognized yet in general pathology or dermatopathology. Such lesions have always been misinterpreted as either benign neoplasm or sebaceous carcinoma. In the present essay, we provide a convincing account supporting sebaceous carcinoma in situ as a valid concept and diagnostic entity via critical literature review and histopathological assessment and illustration...
July 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28988763/treatment-of-malignant-cutaneous-adnexal-neoplasms
#19
C Bernárdez, L Requena
Malignant cutaneous adnexal neoplasms form a group of rare, typically low-grade-malignancy carcinomas with follicular, sebaceous, apocrine, or eccrine differentiation or a combination of the first 3 subtypes. Their clinical presentation is usually unremarkable, and biopsy is required to establish the differentiation subtype and the definitive diagnosis. Due to their rarity, no clear consensus has been reached on which treatment is most effective. Mohs micrographic surgery is considered to be the best option to prevent recurrence in the majority of patients...
October 5, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28937433/a-case-of-phacomatosis-pigmentokeratotica-associated-with-multiple-basal-cell-carcinomas
#20
Seung-Hee Loh, Bark-Lynn Lew, Woo-Young Sim
Phacomatosis pigmentokeratotica is a recently identified disease characterized by the coexistence of an epidermal nevus with sebaceous differentiation arranged along Blaschko lines and a speckled lentiginous nevus showing a checkerboard pattern, mostly in association with various extracutaneous defects. A 52-year-old man presented with asymptomatic ulcerative plaque on his left side of perioral area. A 2 × 2-cm-sized fleshy colored ulceration on his left perioral area was consistent with basal cell carcinoma with nevus sebaceous...
September 13, 2017: American Journal of Dermatopathology
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