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sebaceous carcinoma

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https://www.readbyqxmd.com/read/29681840/intraoperative-adjunctive-mitomycin-c-and-cryotherapy-for-recurrent-conjunctival-papillary-sebaceous-carcinoma
#1
Natsuki Monai, Reiko Tanabu, Takayuki Gonome, Katsunori Yokoi, Satoshi Urushidate, Satoko Morohashi, Hideaki Hirai, Akira Kurose, Mitsuru Nakazawa
Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy. Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#2
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29629953/utility-of-ber-ep4-and-moc-31-in-basaloid-skin-tumor-detection
#3
Pavandeep Gill, Christopher Naugler, Marie S Abi Daoud
Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions...
April 7, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29607000/basaloid-follicular-hamartoma-a-case-report-and-a-novel-cosmetic-treatment
#4
Kelly Segars, Hassie Cooper, Daniel J Hogan, Richard Miller, Michael Heaphy, James Spencer
Introduction: Basaloid follicular hamartoma (BFH) is a rare, benign neoplasm of the hair follicle, characterized by multiple brown papules involving the face, scalp, and trunk. It is described by multiple clinical forms, and can present as localized or generalized. Diagnosis is made histologically via biopsy, which is important in order to distinguish BFH from basal cell carcinoma (BCC) or other malignant epithelial neoplasms. Correct diagnosis allows for the avoidance of unnecessary surgeries to remove benign lesions...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29578884/impact-of-muir-torre-syndrome-on-survival-in-patients-with-sebaceous-carcinoma-a-seer-population-based-study
#5
Raghav Tripathi, Jeremy S Bordeaux
No abstract text is available yet for this article.
March 23, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29575201/sebaceous-carcinoma-of-the-breast-in-a-patient-with-a-pathogenic-brca2-886delgt-mutation-focus-on-histopathologic-and-immunohistochemical-features
#6
Andres M Acosta, Mohamed R Haroon Al Rasheed, Haoliang Xu, Christine Salibay, Michael R Pins
Sebaceous carcinoma of the breast (SCB) is a rare variant of ductal carcinoma arising within the mammary gland and containing at least 50% of malignant cells with sebaceous differentiation. Only 11 cases that adjust to the criteria delineated in the WHO classification have been published in the English literature, to the best of our knowledge. Here, we present the first SCB arising in the context of a deleterious BRCA2 mutation, focusing on the histopathologic and immunohistochemical features of this exceedingly rare tumor...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29563690/eyelid-sebaceous-gland-carcinoma-varied-presentations-and-reconstruction-outcome
#7
Syed Ali Raza Rizvi, Md Shahid Alam, Kafil Akhtar
PURPOSE: To analyze varying clinical presentations, histopathological features, and management outcome of sebaceous gland carcinoma (SGC) of the eyelid. MATERIALS AND METHODS: We retrospectively reviewed medical records of 30 patients with histologically proven cases of SGC of eyelid treated at tertiary care hospital. RESULTS: Patients were in the age group of 28-80 years, among which 18 (60%) were females and 12 (40%) were males. Mean follow-up period was 29...
January 2018: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29556777/breast-sebaceous-carcinoma-a-rare-entity-clinico-pathological-description-of-two-cases-and-brief-review
#8
Tiago Maia, Isabel Amendoeira
No abstract text is available yet for this article.
March 19, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29538586/largest-case-series-of-latin-american-eyelid-tumors-over-13-years-from-a-single-center-in-sao-paulo-brazil
#9
Jéssica Carolinne Damasceno, Jordan Isenberg, Laíse Rondon Lopes, Bernardo Hime, Bruno F Fernandes, Marcia Lowen, Luis Marcelo Aranha Camargo, Rubens N Belfort
PURPOSE: Malignant lesions of the eyelid are the most common eye cancers. Although rarely lethal, late diagnosis can lead to serious visual morbidity. Definitive diagnosis of neoplastic lesions is pathological. Indications and types of eyelid lesions in a single high-volume ophthalmic reference center in Sao Paulo, Brazil, were analyzed. METHODS: The surgical pathological reports of patients who underwent eye removal procedures between January 2000 and December 2012 were retrieved from the electronic database of the Ophthalmology Department and retrospectively reviewed...
January 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29498454/sebaceous-carcinoma-of-the-breast-histological-cytological-and-ultrastructural-features
#10
Yasuhiro Sakai, Makoto Ohta, Yoshiaki Imamura
No abstract text is available yet for this article.
March 2, 2018: Breast Journal
https://www.readbyqxmd.com/read/29491614/cutaneous-horn-a-mask-to-underlying-malignancy
#11
Rashmi Gs Phulari, Rajendrasinh Rathore, Trupti Pramod Talegaon, Arpan Shah
Cutaneous horns ( cornu cutaneum ) are uncommon lesions consisting of keratotic material resembling that of an animal horn. It is a conical- or cylindrical-shaped excessive hyperkeratosis of variable size ranging from few millimeters to several centimeters with a variable in size and shape, such as cylindrical, conical, pointed, transversely or longitudinally corrugated, or curved like a ram's horn. The lesions typically occur in sun-exposed areas, particularly the face, ear, nose, forearms and dorsum of hands...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29491610/keratinizing-pleomorphic-adenoma-an-unusual-case-report
#12
Aanchal Tandon, Rohit Jaiswal, Safia Siddiqui, Bharadwaj Bordoloi
Pleomorphic adenoma (PA) is the most common benign tumor of major or minor salivary glands. PA exhibits a great histological diversity, such as differentiation into oncocytic, sebaceous, mucinous, squamous, chondroid, osseous or adipose cells. Squamous metaplasia rarely results in the formation of extensive keratin-filled cyst lined by squamous epithelium. Extensive squamous metaplasia can be mistaken for malignancy, including mucoepidermoid carcinoma and squamous cell carcinoma. Here, we report a case of slowly enlarging PA with extensive squamous metaplasia and keratin cyst formations in a minor salivary gland in hard palate and discuss its microscopic features...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29478030/immunohistochemical-evaluation-of-stress-responsive-protein-sestrin2-and-its-correlation-with-p53-mutational-status-in-eyelid-sebaceous-gland-carcinoma
#13
Perumal Jayaraj, Seema Sen, Srishti Rangarajan, Neelanjana Ray, Kirtana Vasu, Vijay Kumar Singh, Rajendra Phartyal, Sarika Yadav, Anita Verma
BACKGROUND: p53 is a stress-activated tumour suppressor gene, and its mutation has been associated with solid tumours including non-melanoma skin cancers. Sestrin2 expression is associated with DNA damage and oxidative stress and has been described as a downstream target of p53 network. However, its role in sebaceous gland carcinoma (SGC) remains unexplored. OBJECTIVES: To determine the role of p53 and its downstream target gene sestrin2 expression and p53 gene mutation status in SGC...
February 24, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29459429/14-year-case-series-of-eyelid-sebaceous-gland-carcinoma-in-chinese-patients-and-review-of-management
#14
Stacey C Lam, Emmy Y M Li, Hunter K L Yuen
AIMS: Sebaceous gland carcinoma (SGC) of the eyelid is a rare but potentially deadly cancer. The purpose of this study was to determine whether the American Joint Committee on Cancer (AJCC) 7th Edition T category for SGC correlated with metastasis and survival in the Chinese population. METHODS: This was a retrospective, single-centre cohort study. Patients with surgically resected eyelid SGC between January 2001 and May 2015 at the Hong Kong Eye Hospital were reviewed...
February 19, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29436004/homeobox-transcriptional-factor-engrailed-homeobox-1-is-specifically-expressed-in-normal-and-neoplastic-sweat-gland-cells
#15
Keiko Miura, Takumi Akashi, Noboru Ando, Shinya Ayabe, Kou Kayamori, Takeshi Namiki, Yoshinobu Eishi
AIM: A number of homeobox transcriptional factors are utilized as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is specifically expressed in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms. METHODS AND RESULTS: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be specifically expressed in the skin...
February 12, 2018: Histopathology
https://www.readbyqxmd.com/read/29431200/gata3-staining-in-primary-cutaneous-apocrine-cribriform-carcinoma-usefulness-to-differentiate-it-from-breast-cancer-metastasis
#16
Mar Llamas-Velasco, Yosmar C Pérez-Gónzalez, Esteban Daudén, Arno Rütten
BACKGROUND: Primary cutaneous apocrine cribriform carcinoma (PCACC) is a rare tumor, clinically appearing as a solitary nodule, mostly involving extremities of females and this lesion usually raises a differential diagnosis with metastatic cribriform carcinomas, especially breast cancer. OBJECTIVE: To study GATA3 expression in a series of 14 primary cutaneous cribriform carcinomas and to test its usefulness to differentiate this tumor from metastatic breast cancer...
February 12, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29423837/analysis-of-hedgehog-signaling-in-periocular-sebaceous-carcinoma
#17
John C Bladen, Mariya Moosajee, Dhani Tracey-White, Michèle Beaconsfield, Edel A O'Toole, Michael P Philpott
PURPOSE: Sebaceous carcinoma (SC) is a clinical masquerader of benign conditions resulting in significant eye morbidity, sometimes leading to extensive surgical treatment including exenteration, and even mortality. Little is known about the genetic or molecular basis of SC. This study identifies the involvement of Hedgehog (Hh) signaling in periocular SC. METHODS: Fifteen patients with periocular SC patients were compared to 15 patients with eyelid nodular basal cell carcinoma (nBCC; a known Hh tumor), alongside four normal individuals as a control for physiological Hh expression...
February 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29364442/rare-desmoplastic-trichilemmoma-associated-with-sebaceous-nevus
#18
Márcio Martins Lobo Jardim, Bruno de Castro E Souza, Renata Cavanellas Fraga, Rafael Cavanellas Fraga
Nevus sebaceous of Jadassohn is a congenital hamartoma that usually affects the scalp and face. Several benign or malignant neoplasias may develop in the lesion and the most common are trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma. Trichilemmoma is a benign solid tumor originating from external sheath cells of pilosebaceous follicles. When it is characterized by a central zone of desmoplasia, it is called desmoplastic trichilemmoma. We report a case of a 58-year-old patient who developed a tumor in a sebaceous nevus...
November 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29352496/microcystic-adnexal-carcinoma-with-sebaceous-differentiation-three-cases
#19
Angel Fernandez-Flores, Mar Llamas-Velasco, Carles Saus, Anisha Patel, Arno Rutten
Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful...
April 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29329503/chemical-imaging-of-aggressive-basal-cell-carcinoma-using-time-of-flight-secondary-ion-mass-spectrometry
#20
Marwa Munem, Oscar Zaar, Kelly Dimovska Nilsson, Noora Neittaanmäki, John Paoli, John S Fletcher
A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface...
January 12, 2018: Biointerphases
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