Francesca Menotti, Sara Scutera, Eleonora Maniscalco, Bartolomeo Coppola, Alessandro Bondi, Cristina Costa, Fabio Longo, Narcisa Mandras, Claudia Pagano, Lorenza Cavallo, Giuliana Banche, Mery Malandrino, Paola Palmero, Valeria Allizond
Candida spp. periprosthetic joint infections are rare but difficult-to-treat events, with a slow onset, unspecific symptoms or signs, and a significant relapse risk. Treatment with antifungals meets with little success, whereas prosthesis removal improves the outcome. In fact, Candida spp. adhere to orthopedic devices and grow forming biofilms that contribute to the persistence of this infection and relapse, and there is insufficient evidence that the use of antifungals has additional benefits for anti-biofilm activity...
February 28, 2024: International Journal of Molecular Sciences