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https://www.readbyqxmd.com/read/28428726/successful-treatment-of-prosthetic-joint-infection-due-to-vancomycin-resistant-enterococci-with-tedizolid
#1
Sheng Si, Michael J Durkin, Maureen M Mercier, Melanie L Yarbrough, Stephen Y Liang
Few antibiotic options exist for the management of infections due to vancomycin-resistant enterococci (VRE). We describe a case involving the safe and successful use of tedizolid, a new oxazolidinone, to treat VRE prosthetic joint infection.
March 2017: Infectious Diseases in Clinical Practice: IDCP
https://www.readbyqxmd.com/read/28422662/use-of-accelerometers-in-the-control-of-practical-prosthetic-arms
#2
Peter Kyberd, Adrian Poulton
Accelerometers can be used to augment the control of powered prosthetic arms. They can detect the orientation of the joint and limb and the controller can correct for the amount of torque required to move the limb. They can also be used to create a platform, with a fixed orientation relative to gravity for the object held in the hand. This paper describes three applications for this technology, in a powered wrist and powered arm. By adding sensors to the arm making these data available to the controller, the input from the user can be made simpler...
April 12, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28412103/reverse-shoulder-arthroplasty-compared-with-hemiarthroplasty-in-the-treatment-of-acute-proximal-humeral-fractures
#3
Michael van der Merwe, Matthew J Boyle, Christopher M A Frampton, Craig M Ball
BACKGROUND: Complex proximal humeral fractures may require prosthetic replacement of the humeral head. Surgical options include reverse shoulder arthroplasty (RSA) and shoulder hemiarthroplasty; however, the optimal technique remains controversial. The goal of this study was to compare functional outcomes and revision rates of RSA with hemiarthroplasty in patients with acute proximal humeral fractures. MATERIALS AND METHODS: Between January 1, 1999, and December 31, 2014, there were 218 patients who underwent RSA and 427 who underwent hemiarthroplasty for acute proximal humeral fractures identified through New Zealand Joint Registry records...
April 12, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28407472/introduction-to-the-centers-for-disease-control-and-prevention-and-healthcare-infection-control-practices-advisory-committee-guideline-for-prevention-of-surgical-site-infection-prosthetic-joint-arthroplasty-section
#4
John Segreti, Javad Parvizi, Elie Berbari, Philip Ricks, Sandra I Berríos-Torres
Peri-prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty that appears to be increasing as more of these procedures are performed. Numerous risk factors for incisional (superficial and deep) and organ/space (e.g., PJI) surgical site infections (SSIs) have been identified. A better understanding and reversal of modifiable risk factors may lead to a reduction in the incidence of incisional SSI and PJI. The Centers for Disease Control and Prevention (CDC) and the Healthcare Infection Control Practices Advisory Committee (HICPAC) recently updated the national Guideline for Prevention of Surgical Site Infection...
April 13, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28407419/antibiotic-treatment-of-biofilm-infections
#5
REVIEW
Oana Ciofu, Estrella Rojo-Molinero, María D Macià, Antonio Oliver
Bacterial biofilms are associated with a wide range of infections, from those related to exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such as those occurring in the lungs of cystic fibrosis patients. Biofilms are recalcitrant to antibiotic treatment due to multiple tolerance mechanisms (phenotypic resistance). This causes persistence of biofilm infections in spite of antibiotic exposure which predisposes to antibiotic resistance development (genetic resistance). Understanding the interplay between phenotypic and genetic resistance mechanisms acting on biofilms, as well as appreciating the diversity of environmental conditions of biofilm infections which influence the effect of antibiotics are required in order to optimize the antibiotic treatment of biofilm infections...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28405377/modulation-of-leg-joint-function-to-produce-emulated-acceleration-during-walking-and-running-in-humans
#6
Dominic James Farris, Brent J Raiteri
Understanding how humans adapt gait mechanics for a wide variety of locomotor tasks is important for inspiring the design of robotic, prosthetic and wearable assistive devices. We aimed to elicit the mechanical adjustments made to leg joint functions that are required to generate accelerative walking and running, using metrics with direct relevance to device design. Twelve healthy male participants completed constant speed (CS) walking and running and emulated acceleration (ACC) trials on an instrumented treadmill...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28403859/managing-uncertainty-a-qualitative-study-of-surgeons-decision-making-for-one-stage-and-two-stage-revision-surgery-for-prosthetic-hip-joint-infection
#7
Andrew J Moore, Ashley W Blom, Michael R Whitehouse, Rachael Gooberman-Hill
BACKGROUND: Approximately 88,000 primary hip replacements are performed in England and Wales each year. Around 1% go on to develop deep prosthetic joint infection. Between one-stage and two-stage revision arthroplasty best treatment options remain unclear. Our aims were to characterise consultant orthopaedic surgeons' decisions about performing either one-stage or two-stage revision surgery for patients with deep prosthetic infection (PJI) after hip arthroplasty, and to identify whether a randomised trial comparing one-stage with two-stage revision would be feasible...
April 12, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28400660/anthropometric-analysis-of-the-hip-joint-in-south-indian-population-using-computed-tomography
#8
Vetrivel Chezian Sengodan, Elangovan Sinmayanantham, J Saravana Kumar
BACKGROUND: Proximal femur has a significant functional modification on erect bipedal posture. Various proximal femoral parameters were analyzed in Western literature. This information was utilized in prosthetic designing. Implants designed for Western people are used in Indian patients undergoing hip surgeries such as internal fixation and replacement arthroplasty. MATERIALS AND METHODS: The study was done among 200 individuals (400 hips) with a normal hip joint after ethical committee clearance...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28399323/short-stem-reverse-total-shoulder-arthroplasty-periprosthetic-type-a-fracture
#9
Bryan M Saltzman, Timothy Leroux, Michael J Collins, Thomas A Arns, Brian Forsythe
Alterations have been made over the years to the standard reverse total shoulder arthroplasty (RTSA) prosthetic components in an effort to decrease adverse events; this has led to the advent of a short humeral stem prosthesis. To the authors' knowledge, there are no reports describing the complication of a traumatic periprosthetic Wright and Cofield classification type A fracture with use of a short metaphyseal humeral stem component for RTSA. The authors describe a 49-year-old woman with this pathology who was treated with open reduction and internal fixation using a proximal humerus locking plate, unicortical and bicortical screw fixation, and a cerclage wire construct without the need to violate the shoulder joint or revise components...
April 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/28393758/prosthetic-joint-and-implant-contamination-caused-by-ralstonia-pickettii-a-report-of-three-cases%C3%B9
#10
Brett D Edwards, Ranjani Somayaji, Bayan Missaghi, Wilson W Chan, Aaron J Bois
We describe three cases of orthopaedic contamination caused by Ralstonia pickettii grown from prosthetic joint and implant material cultures following sonication in the microbiology laboratory. Given the temporal association between the cases, lack of clinical or intra-operative features of infection, growth of the organism in the water bath, and unlikely etiology of Ralstonia as a prosthetic joint or implant pathogen, the bacteria were judged to be contaminants.
2017: SICOT-J
https://www.readbyqxmd.com/read/28392969/preliminary-experiments-with-a-unified-controller-for-a-powered-knee-ankle-prosthetic-leg-across-walking-speeds
#11
David Quintero, Dario J Villarreal, Robert D Gregg
This paper presents the experimental validation of a novel control strategy that unifies the entire gait cycle of a powered knee-ankle prosthetic leg without the need to switch between controllers for different periods of gait. Current control methods divide the gait cycle into several sequential periods each with independent controllers, resulting in many patient-specific control parameters and switching rules that must be tuned for a specific walking speed. The single controller presented is speed-invariant with a minimal number of control parameters to be tuned...
October 2016: Proceedings of the ... IEEE/RSJ International Conference on Intelligent Robots and Systems
https://www.readbyqxmd.com/read/28390886/epidemiology-and-antibiotic-resistance-of-late-prosthetic-knee-and-hip-infections
#12
Lorenzo Drago, Elena De Vecchi, Monica Bortolin, Luigi Zagra, Carlo L Romanò, Laura Cappelletti
BACKGROUND: Prosthetic joint infections (PJI) are still a major complication of hip and knee arthroplasties. Identification of the causative pathogens and knowledge of their antibiotic susceptibilities are essential for the management of these infections. The main purpose of the study was to identify and compare the causative bacteria of prosthetic knee and hip joint infections in a reference Italian orthopedic center and to characterize antibiotic resistance profiles of bacteria involved...
March 15, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28390607/endoscopic-middle-ear-exploration-in-pediatric-patients-with-conductive-hearing-loss
#13
John M Carter, Stephen R Hoff
OBJECTIVE: To describe our indications, findings, and outcomes for transcanal endoscopic middle ear exploration in pediatric patients with conductive hearing loss of unknown etiology, without effusions. METHODS: Prospective case series for all pediatric patients undergoing totally endoscopic transcanal middle ear exploration between April 2012 and October 2015 at a pediatric tertiary care referral hospital. Demographic data, operative findings, and hearing results were reviewed...
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28389926/influence-of-molecular-characteristics-in-the-prognosis-of-methicillin-resistant-staphylococcus-aureus-prosthetic-joint-infections-beyond-the-species-and-the-antibiogram
#14
Irene Muñoz-Gallego, Jaime Lora-Tamayo, Dafne Pérez-Montarelo, Patricia Brañas, Esther Viedma, Fernando Chaves
We have explored the relationship of phenotypic (antibiogram, β-haemolysis, agr functionality, biofilm formation) and genotypic characteristics on the prognosis of 18 cases of methicillin-resistant S. aureus prosthetic joint infection (2005-2015). All isolates belonged to CC5, and had agr type II. This pilot study suggests that phage-borne genes belonging to the immune evasion cluster (chp, sak and scn) were more frequent among episodes with treatment failure (80.0 vs. 37.5%).
April 7, 2017: Infection
https://www.readbyqxmd.com/read/28379472/a-possible-novel-prosthetic-joint-infection-pathogen-mycoplasma-salivarium-identified-by-metagenomic-shotgun-sequencing
#15
Matthew Thoendel, Patricio Jeraldo, Kerryl E Greenwood-Quaintance, Nicholas Chia, Matthew P Abdel, James M Steckelberg, Douglas R Osmon, Robin Patel
Defining the microbial etiology of culture-negative prosthetic joint infection (PJI) can be challenging. Metagenomic shotgun sequencing is a new tool to identify organisms undetected by conventional methods. We present a case where metagenomics was used to identify Mycoplasma salivarium as a novel PJI pathogen in a hypogammaglobulinemic individual.
April 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28378243/prolonged-suppressive-antibiotic-therapy-for-prosthetic-joint-infection-in-the-elderly-a-national-multicentre-cohort-study
#16
V Prendki, T Ferry, P Sergent, E Oziol, E Forestier, T Fraisse, S Tounes, S Ansart, J Gaillat, S Bayle, O Ruyer, F Borlot, G Le Falher, B Simorre, F-A Dauchy, S Greffe, T Bauer, E N Bell, B Martha, M Martinot, M Froidure, M Buisson, A Waldner, X Lemaire, A Bosseray, M Maillet, V Charvet, A Barrelet, B Wyplosz, M Noaillon, E Denes, E Beretti, M Berlioz-Thibal, V Meyssonnier, E Fourniols, L Tliba, A Eden, M Jean, C Arvieux, K Guignery-Kadri, C Ronde-Oustau, Y Hansmann, A Belkacem, F Bouchand, G Gavazzi, F Herrmann, J Stirnemann, A Dinh
During prosthetic joint infection (PJI), optimal surgical management with exchange of the device is sometimes impossible, especially in the elderly population. Thus, prolonged suppressive antibiotic therapy (PSAT) is the only option to prevent acute sepsis, but little is known about this strategy. We aimed to describe the characteristics, outcome and tolerance of PSAT in elderly patients with PJI. We performed a national cross-sectional cohort study of patients >75 years old and treated with PSAT for PJI...
April 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28372916/oral-therapy-microbiological-findings-and-comorbidity-influence-the-outcome-of-prosthetic-joint-infections-undergoing-2-stage-exchange
#17
Tiziana Ascione, Pasquale Pagliano, Giovanni Balato, Massimo Mariconda, Renato Rotondo, Silvano Esposito
BACKGROUND: The aim of the present study was to investigate potential predictive factors of an unfavorable outcome in patients with prosthetic joint infection (PJI) undergoing 2-stage exchange. METHODS: Patients with PJI undergoing 2-stage exchange and observed over a 5-year period (2009-2013) were included. Cure was defined by the disappearance of infection after a 96-week follow-up period. Statistical analysis was performed using the Mann-Whitney U test, the Fisher exact test, and the multivariate analysis...
March 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28371783/monocular-vision-and-imu-based-system-for-prosthesis-pose-estimation-during-total-hip-replacement-surgery
#18
Shaojie Su, Yixin Zhou, Zhihua Wang, Hong Chen
The average age of population increases worldwide, so does the number of total hip replacement surgeries. Total hip replacement, however, often involves a risk of dislocation and prosthetic impingement. To minimize the risk after surgery, we propose an instrumented hip prosthesis that estimates the relative pose between prostheses intraoperatively and ensures the placement of prostheses within a safe zone. We create a model of the hip prosthesis as a ball and socket joint, which has four degrees of freedom (DOFs), including 3-DOF rotation and 1-DOF translation...
March 30, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28369296/the-not-so-good-prognosis-of-streptococcal-periprosthetic-joint-infection-managed-by-implant-retention-the-results-of-a-large-multicenter-study
#19
Jaime Lora-Tamayo, Éric Senneville, Alba Ribera, Louis Bernard, Michel Dupon, Valérie Zeller, Ho Kwong Li, Cédric Arvieux, Martin Clauss, Ilker Uçkay, Dace Vigante, Tristan Ferry, José Antonio Iribarren, Trisha N Peel, Parham Sendi, Nina Gorišek Miksic, Dolors Rodríguez-Pardo, María Dolores Del Toro, Marta Fernández-Sampedro, Ulrike Dapunt, Kaisa Huotari, Joshua S Davis, Julián Palomino, Danielle Neut, Benjamin M Clark, Thomas Gottlieb, Rihard Trebše, Alex Soriano, Alberto Bahamonde, Laura Guío, Alicia Rico, Mauro Jc Salles, M José G Pais, Natividad Benito, Melchor Riera, Lucía Gómez, Craig A Aboltins, Jaime Esteban, Juan Pablo Horcajada, Karina O'Connell, Matteo Ferrari, Gábor Skaliczki, Rafael San Juan, Javier Cobo, Mar Sánchez-Somolinos, Antonio Ramos, Efthymia Giannitsioti, Alfredo Jover-Sáenz, Josu Mirena Baraia-Etxaburu, José María Barbero, Peter F M Choong, Nathalie Asseray, Séverine Ansart, Gwenäel Le Moal, Werner Zimmerli, Javier Ariza
Background: Streptococci are not an infrequent cause of periprosthetic joint infection (PJI). Management by debridement, antibiotics, and implant retention (DAIR) is thought to produce a good prognosis, but little is known about the real likelihood of success. Methods: Retrospective, observational, multicenter, international study performed during 2003-2012. Eligible patients had a streptococcal PJI that was managed with DAIR. The primary endpoint was failure, defined as death related to infection, relapse/persistence of infection, or the need for salvage therapy...
March 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28366224/management-of-prosthetic-joint-infection
#20
REVIEW
Aaron J Tande, Eric O Gomez Urena, Elie F Berbari, Douglas R Osmon
Although uncommon, prosthetic joint infection is a devastating complication. This challenging condition requires a coordinated management approach to achieve good patient outcomes. This review details the general principles to consider when managing patients with prosthetic joint infection. The different medical/surgical treatment strategies and how to appropriately select a strategy are discussed. The data to support each strategy are presented, along with discussion of antimicrobial strategies in specific situations...
March 30, 2017: Infectious Disease Clinics of North America
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