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https://www.readbyqxmd.com/read/27920813/densitometric-evaluation-of-bone-prosthetic-counterface-in-hip-and-knee-arthroplasty-with-modern-implants
#1
Andrea Cozzi Lepri, Marco Giorgini, Carla Signorini, Christian Carulli, Roberto Civinini, Maria Luisa Brandi, Massimo Innocenti
INTRODUCTION: Recent acquisitions of the complex mechanisms of osseointegration between implants and host bone have gained attention, accordingly to the methods of evaluation of these interactions. DEXA analysis is considered an useful tool to assess such phenomena, in order to analyse in a quantitative manner the local metabolic activity of the bone, and to evaluate over the time the integration between host bone and prosthetic components. The purpose of the present study is to report about a preliminary experience in the analysis of osseointegration processes of patients undergoing a primary Total Hip Arthroplasty (THA) or a revision Total Knee Arthroplasty (rTKA)...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27920810/hyaluronic-acid-in-the-management-of-osteoarthritis-injection-therapies-innovations
#2
Valter Santilli, Marco Paoloni, Massimiliano Mangone, Federica Alviti, Andrea Bernetti
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Viscosupplementation with intra-articular (IA) hyaluronic acid (HA) could be a treatment option in OA, however recommendations made in different international guidelines for the non-surgical management of OA are not always concordant with regard to the role of IA injection therapies. Results from a recent Italian Consensus Conference underline how IA-HA to treat OA represents a widely used therapy in Italy...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27919672/a-study-of-pre-operative-presence-of-micro-organisms-in-affected-knee-joints-of-rheumatoid-arthritis-patients-who-need-total-knee-arthroplasty
#3
Jiang-Ming Luo, Lin Guo, Hao Chen, Peng-Fei Yang, Ran Xiong, Yang Peng, Liu Yang
BACKGROUND: To evaluate, by way of intraoperative tissue culture and pathological study, the pre-operative presence of micro-organisms in knee joints of patients with rheumatoid arthritis (RA) who need total knee arthroplasty (TKA). METHODS: From November 2012 to January 2014, 47 patients with RA (53 knees) who needed TKA were included in this study. Patients received routine pre-operative examination and joint fluid routine and culture. Each RA patient was match-paired with one osteoarthritis (OA) patient...
December 2, 2016: Knee
https://www.readbyqxmd.com/read/27918885/mutant-ccl2-protein-coating-mitigates-wear-particle-induced-bone-loss-in-a-murine-continuous-polyethylene-infusion-model
#4
Akira Nabeshima, Jukka Pajarinen, Tzu-Hua Lin, Xinyi Jiang, Emmanuel Gibon, Luis A Córdova, Florence Loi, Laura Lu, Eemeli Jämsen, Kensuke Egashira, Fan Yang, Zhenyu Yao, Stuart B Goodman
Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the most important chemokine regulating trafficking of monocyte/macrophages in particle-induced inflammation. 7ND recombinant protein is a mutant of CCL2 that inhibits CCL2 signaling. We have recently developed a layer-by-layer (LBL) coating platform on implant surfaces that can release biologically active 7ND...
November 24, 2016: Biomaterials
https://www.readbyqxmd.com/read/27913783/three-dimensional-printed-prosthesis-demonstrates-functional-improvement-in-a-patient-with-an-amputated-thumb-a-technical-note
#5
Keun Ho Lee, Sung Jae Kim, Yong Ho Cha, Jae Lim Kim, Dong Kyu Kim, Sang Jun Kim
BACKGROUND AND AIM: Three-dimensional printer is widely used in industry, biology, and medical fields. We report a finger prosthesis produced by a three-dimensional scanner and printer for a 67-year-old man with a right thumb amputation above the metacarpophalangeal joint. TECHNIQUE: His right amputated and left intact hands were scanned with a three-dimensional scanner, and the left-hand image was rotated to the right side to design the right thumb prosthesis. The designed prosthesis was printed with a three-dimensional printer using the fused filament fabrication output system...
December 1, 2016: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/27912753/radiographic-evaluation-of-early-periprosthetic-acetabular-bone-contrast-and-prosthetic-head-acetabular-coverage-after-uncemented-and-cemented-total-hip-prosthesis-in-dogs
#6
Ayman A Mostafa, Karin Lucas, Ingo Nolte, Patrick Wefstaedt
BACKGROUND: Coxofemoral osteoarthritis is a chronic, disabling condition affecting people and dogs, with THA providing an excellent return to function in severely affected joints. The principal role of THA is to restore an adequate range of motion to the hip joint while transferring load from the acetabulum in order to improve the survival of the implant and enhance the limb function in the short and long terms. The objectives of the study reported here were, therefore, to radiographically evaluate periprosthetic acetabular bone GV and to assess prosthetic head acetabular coverage after 4 months of uncemented and cemented THA in dogs...
December 3, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27910817/on-the-molecular-interaction-between-femoral-heads-and-polyethylene-liners-in-artificial-hip-joints-phenomenology-and-molecular-scale-phenomena
#7
Giuseppe Pezzotti, B Sonny Bal, Elisa Casagrande, Nobuhiko Sugano, Bryan J McEntire, Wenliang Zhu, Leonardo Puppulin
The chemical interaction of femoral heads with polyethylene liners is an important new area of research in total hip arthroplasty (THA) as a consequence of an unabating quest for elongated artificial joint lifetimes. It is a topic that goes beyond simple mechanical behavior or wear. It seeks to describe the prosthetic device as a whole by adding chemical considerations to mechanics and abrasion. One of the poorly understood chemical interactions is oxygen affinity of the femoral heads. While oxygen unavoidably diffuses into the non-crystalline enclaves of the polyethylene liner as a result of its contact with the tribolayer, a ceramic femoral head can either attract or release oxygen due to its tribochemical interactions...
December 2, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27893033/effect-of-a-decision-aid-on-access-to-total-knee-replacement-for-black-patients-with-osteoarthritis-of-the-knee-a-randomized-clinical-trial
#8
Said A Ibrahim, Marissa Blum, Gwo-Chin Lee, Pekka Mooar, Elina Medvedeva, Aliya Collier, Diane Richardson
Importance: Black patients with advanced osteoarthritis (OA) of the knee are significantly less likely than white patients to undergo surgery. No strategies have been proved to improve access to surgery for black patients with end-stage OA of the knee. Objective: To assess whether a decision aid improves access to total knee replacement (TKR) surgery for black patients with OA of the knee. Design, Setting, and Participants: In a randomized clinical trial, 336 eligible participants who self-identified as black and 50 years or older with chronic and frequent knee pain, a Western Ontario McMaster Universities Osteoarthritis Index score of at least 39, and radiographic evidence of OA of the knee were recruited from December 1, 2010, to May 31, 2014, at 3 medical centers...
November 23, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27891243/a-comprehensive-musculoskeletal-and-peripheral-nervous-system-assessment-of-war-related-bilateral-upper-extremity-amputees
#9
Mostafa Allami, Batool Mousavi, Mehdi Masoumi, Ehsan Modirian, Hadi Shojaei, Fatemeh Mirsalimi, Maryam Hosseini, Pirouz Pirouzi
BACKGROUND: Upper limb amputations are one of the unpleasant war injuries that armed forces are exposed to frequently. The present study aimed to assess the musculoskeletal and peripheral nervous systems in Iraq-Iran war veterans with bilateral upper extremity amputation. METHODS: The study consisted of taking a history and clinical examinations including demographic data, presence and location of pain, level of amputation, passive and active ranges of movement of the joints across the upper and lower extremities and spine, manual palpation, neurological examination, blood circulation pulses and issues related to a prosthetic limb...
2016: Military Medical Research
https://www.readbyqxmd.com/read/27891054/patellofemoral-joint-arthroplasty-our-experience-in-isolated-patellofemoral-and-bicompartmental-arthritic-knees
#10
L Sabatini, M Schirò, F Atzori, G Ferrero, A Massè
INTRODUCTION: Isolated patellofemoral (PF) arthritis is rare, and there is no complete agreement about the best surgical treatment. The operative treatments are total knee arthroplasty and patellofemoral replacement (PFR). The incidence of many early complications of PF arthroplasty has decreased with the introduction of newer designs. Nowadays, the main cause of revision surgery is the progression of tibiofemoral osteoarthritis. In the past, PF arthroplasty was contraindicated in patients with evidence of osteoarthritis or pain in medial or lateral tibiofemoral compartments...
2016: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27890623/sirt1-protects-osteoblasts-against-particle-induced-inflammatory-responses-and-apoptosis-in-aseptic-prosthesis-loosening
#11
Zhantao Deng, Zhenheng Wang, Jiewen Jin, Yong Wang, Nirong Bao, Qian Gao, Jianning Zhao
: We hypothesized that SIRT1 downregulation in osteoblasts induced by wear particles was one of the reasons for particle-induced osteolysis (PIO) in total joint arthroplasty failure. In the present study, the expression of SIRT1 was examined in osteoblasts treated with TiAl6V4 particles (TiPs) and CoCrMo particles (CoPs) from materials used in prosthetics and specimens from PIO animal models. To address whether SIRT1 downregulation triggers inflammatory responses and apoptosis in osteoblasts, the effect of a SIRT1 activator, resveratrol on the expression of inflammatory cytokines and apoptosis in particle-treated osteoblasts was tested...
November 23, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27889664/macrophage-integrins-modulate-response-to-ultra-high-molecular-weight-polyethylene-particles-and-direct-particle-induced-osteolysis
#12
Toral D Zaveri, Natalia V Dolgova, Jamal S Lewis, Kiri Hamaker, Michael J Clare-Salzler, Benjamin G Keselowsky
Aseptic loosening due to peri-prosthetic osteolysis is one of the primary causes for failure of artificial joint replacements. Implant-derived wear particles, often ultra-high molecular weight polyethylene (UHMWPE) microparticles, initiate an inflammatory cascade upon phagocytosis by macrophages, which leads to osteoclast recruitment and activation, ultimately resulting in osteolysis. Investigation into integrin receptors, involved in cellular interactions with biomaterial-adsorbed adhesive proteins, is of interest to understand and modulate inflammatory processes...
October 27, 2016: Biomaterials
https://www.readbyqxmd.com/read/27883369/acinetobacter-prosthetic-joint-infection-treated-with-debridement-and-high-dose-tigecycline
#13
Andrea Vila, Hugo Pagella, Claudio Amadio, Alejandro Leiva
Prosthesis retention is not recommended for multidrug-resistant Acinetobacter prosthetic joint infection due to its high failure rate. Nevertheless, replacing the prosthesis implies high morbidity and prolonged hospitalization. Although tigecycline is not approved for the treatment of prosthetic joint infection due to multidrug resistant Acinetobacter baumannii, its appropriate use may preclude prosthesis exchange. Since the area under the curve divided by the minimum inhibitory concentration is the best pharmacodynamic predictor of its efficacy, we used tigecycline at high dose, in order to optimize its efficacy and achieve implant retention in 3 patients who refused prosthesis exchange...
November 8, 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27876531/patient-centered-quality-of-life-measures-after-alloplastic-temporomandibular-joint-replacement-surgery
#14
X Alakailly, D Schwartz, N Alwanni, C Demko, M A Altay, Y Kilinc, D A Baur, F Quereshy
The purpose of this study was to evaluate patient-reported outcome measures of quality of life (QoL) for patients with end-stage temporomandibular joint (TMJ) disease who have undergone TMJ prosthetic replacement. The records of 36 patients who had undergone alloplastic total joint replacement procedures were analyzed. Patients were treated using either TMJ Concepts or Biomet/Lorenz prosthetics. Patients were asked to complete a 12-item TMJ-S-QoL survey, which encompassed questions pertaining to pain, speech, chewing function, and various aspects of social life and mental health...
November 19, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27869495/a-comparison-of-airborne-bacterial-fallout-between-orthopaedic-and-vascular-surgery
#15
P Stather, M Salji, S-U Hassan, M Abbas, A Ahmed, H Mills, T Elston, C Backhouse, A Howard, S Choksy
INTRODUCTION The objective of the study was to compare bacterial fallout during vascular prosthesis insertion and orthopaedic major joint replacement performed in conventional and laminar flow ventilation, respectively. MATERIALS AND METHODS A prospective single-centre case control study of 21 consecutive elective vascular procedures involving prosthetic graft insertion and 24 consecutive elective orthopaedic major joint replacements were tested for degree of bacterial fallout using agar settle plates. Preparation time, waiting time and total procedure duration were collected at the time of surgery, and bacterial colony counts on the agar settle plates from airborne bacterial fallout were counted after an incubation period...
November 21, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27869063/screening-patients-undergoing-total-hip-or-knee-arthroplasty-with-perioperative-urinalysis-and-the-effect-of-a-practice-change-on-antimicrobial-use
#16
Samuel Bailin, Nicolas Noiseux, Jean M Pottinger, Birgir Johannsson, Ambar Haleem, Sarah Johnson, Loreen A Herwaldt
OBJECTIVE To identify predictors of treatment for urinary tract infections (UTI) among patients undergoing total hip (THA) or knee (TKA) arthroplasties and to assess an intervention based on these predictors. DESIGN We conducted a retrospective cohort study of 200 consecutive patients undergoing THA/TKA between February 21, 2011, and June 30, 2011, to identify predictors of treatment for UTI and a prospective cohort study of 50 patients undergoing these procedures between May 21, 2012, and July 17, 2012, to assess the association of signs or symptoms and UTI treatment...
November 21, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27855064/rifampin-based-combination-therapy-is-active-in-foreign-body-osteomyelitis-after-prior-rifampin-monotherapy
#17
Cassandra L Brinkman, Suzannah M Schmidt-Malan, Jayawant N Mandrekar, Robin Patel
Staphylococcal prosthetic joint infections (PJIs) are associated with biofilm formation, making them difficult to treat; if managed with débridement and implant retention, rifampin-based therapy is usually employed. Rifampin resistance potentially challenges PJI treatment. In investigating the effects of rifampin monotherapy on methicillin-resistant Staphylococcus aureus (MRSA) foreign body osteomyelitis in rats, we previously demonstrated that rifampin resistance was selected but that it disappeared 14 days following rifampin monotherapy (1) and that rifampin resistance occurred less frequently following two rounds than one round of rifampin monotherapy (2)...
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27852674/focus-on-mrsa-sa-ssti%C3%A2-assay-failure-in-prosthetic-joint-infections-213-consecutive-patients-later
#18
Marie Titécat, Frédéric Wallet, Olivier Robineau, Michel Valette, Henri Migaud, Eric Senneville, Caroline Loïez
In prosthetic joint infection (PJI) cases (1), rapid detection of methicillin-resistant staphylococci (MRS) is the key to avoid the use of broad-spectrum antimicrobials such as vancomycin.….
November 16, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27847676/retentive-cup-arthroplasty-in-selected-hip-fracture-patients-a-prospective-series-with-a-minimum-3-year-follow-up
#19
Mustafa Yassin, Avraham Garti, Muhammad Khatib, Moshe Weisbrot, Dror Robinson
OBJECTIVE: To evaluate the efficacy of the use of retentive cup primary total hip replacement (THR) in high-dislocation risk subcapital fracture patients. METHODS: During the years 2008 to 2012, 354 patients with displaced subcapital fracture were operated at our institute. The patients were selected to undergo primary constrained THR according to the following criteria: (1) a preinjury grade 4 or more on the Functional Independence Measure mobility item "5. Locomotion: walking/wheelchair" and grade 4 is defined as "4...
December 2016: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/27842683/allografts-in-aortic-position-insights-from-a-27-year-single-center-prospective-study
#20
Bardia Arabkhani, Jos A Bekkers, Eleni-Rosalina Andrinopoulou, Jolien W Roos-Hesselink, Johanna J M Takkenberg, Ad J J C Bogers
OBJECTIVE: Over the past decades, the indication for allograft implantation in aortic position has evolved. The purpose of this study is to report long-term survival, allograft durability, and potential risk factors. METHODS: Between 1987 and 2010, 353 patients underwent aortic valve replacements via allograft (92 subcoronary, 261 root replacement; 98% aortic allografts). Patient characteristics, survival, valve durability, and valve-related events were analyzed...
December 2016: Journal of Thoracic and Cardiovascular Surgery
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