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Antiangiogenesis

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https://www.readbyqxmd.com/read/29656700/hif-2%C3%AE-ilk-is-involved-in-mesenchymal-stromal-cell-angiogenesis-in-multiple-myeloma-under-hypoxic-conditions
#1
Xiaoying Zhang, Yinhui Xu, Hongbo Liu, Pan Zhao, Yafang Chen, Zhijie Yue, Zhiqing Zhang, Xiaofang Wang
Mesenchymal stromal cells are proven to be likely induce the angiogenic response in multiple myeloma and thus represent an enticing target for antiangiogenesis therapies for multiple myeloma. Substantial evidence indicates that angiogenesis in multiple myeloma is complex and involves direct production of angiogenic cytokines by abnormal plasma cells and these B-cell neoplasia generated pathophysiology change within the microenvironment. In this study, we demonstrated that mesenchymal stromal cells cultured with U266/Lp-1 under hypoxic conditions resulted in an increased α-smooth muscle actin expression and high productive levels of both hypoxia-inducible factor-2α and integrin-linked kinase proteins...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29576875/current-advances-in-pharmacotherapy-and-technology-for-diabetic-retinopathy-a-systematic-review
#2
REVIEW
Lei Lu, Ying Jiang, Ravindran Jaganathan, Yanli Hao
Diabetic retinopathy (DR) is classically defined by its vascular lesions and damage in the neurons of the retina. The cellular and clinical elements of DR have many features of chronic inflammation. Understanding the individual cell-specific inflammatory changes in the retina may lead to novel therapeutic approaches to prevent vision loss. The systematic use of available pharmacotherapy has been reported as a useful adjunct tool to laser photocoagulation, a gold standard therapy for DR. Direct injections or intravitreal anti-inflammatory and antiangiogenesis agents are widely used pharmacotherapy to effectively treat DR and diabetic macular edema (DME)...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29575811/selenadiazole-derivatives-inhibit-angiogenesis-mediated-human-breast-tumor-growth-through-suppressing-vegfr2-mediated-erk-and-akt-signaling-pathway
#3
Haoqiang Lai, Xiaoyan Fu, Chengcheng Sang, Liyuan Hou, Pengju Feng, Xiaoling Li, Tianfeng Chen
Selenadiazole derivatives (SeDs) have been found to show promising application in chemo-/radiotherapy through activating various downstream signaling pathways. However, the functional role of SeDs on angiogenesis, which is pivotal for tumor progression and metastasis, has not been elucidated. In the present study, we have examined the antiangiogenic activities of SeDs and elucidated their underlying mechanisms. The results showed that the as-synthesized SeDs not only enhanced their anti-cancer activities against several human cancer cells, but also showed more potent inhibition on human umbilical vein endothelial cells (HUVECs)...
March 25, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29557658/ws9326h-an-antiangiogenic-pyrazolone-bearing-peptide-from-an-intertidal-mudflat-actinomycete
#4
Munhyung Bae, Jedo Oh, Eun Seo Bae, Joonseok Oh, Joonseong Hur, Young-Ger Suh, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
WS9326H (1), a new cyclic peptide, was isolated from a mudflat-derived Streptomyces strain. Based on analysis by 1D/2D NMR, UV spectroscopy, and mass spectrometry, compound 1 was determined to have the gross structure of a cyclic heptapeptide bearing an unprecedented pyrazolone ring connected to a d-arabinitol via an amide bond. The absolute configuration of 1 was established by multistep chemical derivatizations, comprehensive NMR, and LC/MS analyses of the derivatives and quantum mechanics-based computational methods...
March 20, 2018: Organic Letters
https://www.readbyqxmd.com/read/29544480/fisetin-and-polymeric-micelles-encapsulating-fisetin-exhibit-potent-cytotoxic-effects-towards-ovarian-cancer-cells
#5
Xue Xiao, Juan Zou, Yin Fang, Yibo Meng, Chao Xiao, Jiaxin Fu, Shiyu Liu, Peng Bai, Yuan Yao
BACKGROUND: The anti-tumor activities of Natural compounds and their derivatives are of great interest to pharmaceutical industries. Fisetin is one of prospective natural compounds in this regard but unfortunately with poor hydrophilicity. METHODS: The effects of unmodified and modified fisetin in cultured ovarian cancer cells were compared by transmission electronmicroscopy to determine apoptotic bodies, MTT assay to quantitate cell numbers, and fluorescence activated cell sorting analyse of various markers to determine the apoptotic state...
March 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29542005/realgar-transforming-solution-suppresses-angiogenesis-and-tumor-growth-by-inhibiting-vegf-receptor-2-signaling-in-vein-endothelial-cells
#6
Peng Song, Yang Hai, Xin Wang, Longhe Zhao, Baoqiang Chen, Peng Cui, Qinjian Xie, Lan Yu, Yang Li, Zhengrong Wu, Hongyu Li
Realgar (As4 S4 ), as an arsenic sulfide mineral drug, has a good therapeutic reputation for anticancer in Traditional Chinese Medicine, and has recently been reported to inhibit angiogenesis in tumor growth. However, considering the poor solubility and low bioavailability of realgar, large dose of realgar and long period of treatment are necessary for achieving the effective blood medicine concentration. In present study, we resolved the crucial problem of poor solubility of realgar by using intrinsic biotransformation in microorganism, and investigated underlying mechanisms of realgar transforming solution (RTS) for antiangiogenesis...
March 15, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29528507/potential-lymphangiogenesis-therapies-learning-from-current-antiangiogenesis-therapies-a-review
#7
REVIEW
Michael Yamakawa, Susan J Doh, Samuel M Santosa, Mario Montana, Ellen C Qin, Hyunjoon Kong, Kyu-Yeon Han, Charles Yu, Mark I Rosenblatt, Andrius Kazlauskas, Jin-Hong Chang, Dimitri T Azar
In recent years, lymphangiogenesis, the process of lymphatic vessel formation from existing lymph vessels, has been demonstrated to have a significant role in diverse pathologies, including cancer metastasis, organ graft rejection, and lymphedema. Our understanding of the mechanisms of lymphangiogenesis has advanced on the heels of studies demonstrating vascular endothelial growth factor C as a central pro-lymphangiogenic regulator and others identifying multiple lymphatic endothelial biomarkers. Despite these breakthroughs and a growing appreciation of the signaling events that govern the lymphangiogenic process, there are no FDA-approved drugs that target lymphangiogenesis...
March 12, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29461280/the-rationale-for-a-role-for-diet-and-nutrition-in-the-prevention-and-treatment-of-cancer
#8
Jean Logan, Megan W Bourassa
There is considerable evidence to support dietary recommendations for prevention of cancer as well as for patients undergoing or recovering from cancer treatment. We consider here implications from human, animal and in-vitro studies of the effects of dietary factors (macronutrients and micronutrients-phytochemicals) on cancer. An important epidemiology study, the China Project found a significant correlation between disease incidence and markers of animal product consumption. Evidence of the role of animal protein in the promotion of cancer also comes from animal studies...
February 15, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29383034/combination-of-immunotherapy-with-targeted-therapies-in-advanced-non-small-cell-lung-cancer-nsclc
#9
REVIEW
Irene Moya-Horno, Santiago Viteri, Niki Karachaliou, Rafael Rosell
Treatment for advanced non-small cell lung cancer (NSCLC) has been significantly improved in recent years with the incorporation of drugs targeting antiangiogenesis and more specifically genomic alterations such as the EGFR mutations and ALK translocations. However, most patients invariably progress and die. The emergence of immune checkpoint inhibitors targeting the pathways involved in tumor-induced immunosuppression have redefined the management of the disease, achieving significant long-lasting responses with manageable safety profiles, regardless of histology...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29324343/substituted-tetrahydroisoquinolines-synthesis-characterization-antitumor-activity-and-other-biological-properties
#10
A Sergi Capilla, Richard Soucek, Laura Grau, Manel Romero, Jaime Rubio-Martínez, Daniel H Caignard, Maria Dolors Pujol
This work deals with the molecular design, synthesis and biological activity of a series of tetrahydro[1,4]dioxanisoquinolines and dimethoxyisoquinoline analogues. This study describes the synthesis strategy of these potential antitumor compounds, their multi-step synthesis and their optimization. A series of tetrahydroisoquinolines was synthesized and their cytotoxicity evaluated. Some of these tetrahydroisoquinolines showed promising KRas inhibition, antiangiogenesis activity and antiosteoporosis properties...
February 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29243413/clinical-response-to-apatinib-monotherapy-in-advanced-non-small-cell-lung-cancer
#11
Jianping Xu, Xiaoyan Liu, Sheng Yang, Xiangru Zhang, Yuankai Shi
AIM: Apatinib, an oral tyrosine kinase inhibitor mainly targeting VEGFR-2, exerts both antiangiogenesis and antiproliferation effects. Apatinib shows clinical benefit in advanced non-small cell lung cancer (NSCLC) at an initial dose of 750 mg qd. We further assessed the efficacy and safety of apatinib at a more frequently used dose of 500 mg qd. The preliminary clinical outcome of apatinib in patients with brain metastases was also reported. METHODS: We retrospectively reviewed the clinical data of 25 patients who received apatinib between August 2015 and May 2016...
December 15, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29210417/reactive-oxygen-species-ros-responsive-nanomedicine-for-rnai-based-cancer-therapy
#12
Yang Li, Hongzhen Bai, Hebin Wang, Youqing Shen, Guping Tang, Yuan Ping
Although much effort has been dedicated to the development of efficient siRNA delivery for cancer therapy, delivery nanomaterials that can particularly respond to reactive oxygen species (ROS), which are overproduced in the tissue and mitochondria of cancer cells, are still rare for the clinical translation of RNA interference (RNAi)-based therapy. To this end, we developed a ROS-responsive boronic vehicle with a lipid envelope for systemic vascular endothelial growth factor (VEGF) siRNA delivery so as to improve RNAi cancer therapy...
December 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/29153696/dysregulation-of-circulating-autoantibodies-against-vegf-a-vegfr-1-and-plgf-in-preeclampsia-a-role-in-placental-and-vascular-health
#13
Kjartan Moe, Harald Heidecke, Ralf Dechend, Anne Cathrine Staff
OBJECTIVES: Preeclampsia is a state of antiangiogenesis, with high levels of maternal circulating sVEGFR-1 (soluble vascular endothelial growth factor receptor 1, also named sFlt1) and low levels of PlGF (placenta growth factor). Various autoantibodies have been detected in preeclamptic patients. We hypothesize that circulating autoantibodies against VEGF-A (AA-VEGF-A), VEGFR-1 (AA-VEGFR-1) and PlGF (AA-PlGF) are present in preeclamptic women, with different levels from pregnant women with normotensive pregnancies...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29072683/plasminogen-kringle-5-suppresses-gastric-cancer-via-regulating-hif-1%C3%AE-and-grp78
#14
Shuhuan Fang, Honghai Hong, Lei Li, Dan He, Zumin Xu, Shaoyuan Zuo, Jing Han, Qiyuan Wu, Zhiyu Dai, Weibin Cai, Jianxing Ma, Chunkui Shao, Guoquan Gao, Xia Yang
Inhibition of tumour angiogenesis has an important role in antitumour therapy. However, a recent study indicates that antiangiogenesis therapy may lead to glucose-related protein 78 (GRP78) associated antiapoptotic resistance. The present study aims to elucidate the dual effects of plasminogen kringle 5 (K5) on tumour angiogenesis and apoptosis induction by targeting hypoxia-inducible factor 1α (HIF-1α) and GRP78. Co-immunoprecipitation and western blotting were used for examining the ubiquitination of HIF-1α and analysing angiogenesis and apoptosis-associated proteins...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29066892/bioresponsive-cancer-targeted-polysaccharide-nanosystem-to-inhibit-angiogenesis
#15
Fang Yang, Xueyang Fang, Wenting Jiang, Tianfeng Chen
With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted bioresponsive nanosystem with antiangiogenesis properties. The mUPR@Ru(POP) nanosystem was constructed by the polymerization of Ulva lactuca polysaccharide and N -isopropyl acrylamide, decorated with methoxy polyethylene glycol and Arg-Gly-Asp peptide, and encapsulated with anticancer complex [Ru(phen)2p-MOPIP](PF6 )2 ·2H2 O...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29059175/induction-of-anti-vegf-therapy-resistance-by-upregulated-expression-of-microseminoprotein-msmp
#16
T Mitamura, S Pradeep, M McGuire, S Y Wu, S Ma, H Hatakeyama, Y A Lyons, T Hisamatsu, K Noh, A Villar-Prados, X Chen, C Ivan, C Rodriguez-Aguayo, W Hu, G Lopez-Berestein, R L Coleman, A K Sood
Anti-vascular endothelial growth factor (VEGF) therapy has demonstrated efficacy in treating human metastatic cancers, but therapeutic resistance is a practical limitation and most tumors eventually become unresponsive. To identify microenvironmental factors underlying the resistance of cancer to antiangiogenesis therapy, we conducted genomic analyses of intraperitoneal ovarian tumors in which adaptive resistance to anti-VEGF therapy (B20 antibody) developed. We found that expression of the microseminoprotein, prostate-associated (MSMP) gene was substantially upregulated in resistant compared with control tumors...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29058285/notch4-inhibition-suppresses-invasion-and-vasculogenic-mimicry-formation-of-hepatocellular-carcinoma-cells
#17
Rui Cheng, Xin-Ran Cai, Kun Ke, Yan-Ling Chen
Vasculogenic mimicry (VM) is a process by which aggressive tumor cells generate non-endothelial cell-lined channels in malignant tumors including hepatocellular carcinoma (HCC). It has provided new insights into tumor behavior and has surfaced as a potential target for drug therapy. The molecular events underlying the process of VM formation are still poorly understood. In this study, we attempted to elucidate the relationship between Notch4 and VM formation in HCC. An effective siRNA lentiviral vector targeting Notch4 was constructed and transfected into Bel7402, a HCC cell line...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29057052/new-scaffold-for-angiogenesis-inhibitors-discovered-by-targeted-chemical-transformations-of-wondonin-natural-products
#18
Shuai Yu, Jedo Oh, Feng Li, Yongseok Kwon, Hyunkyung Cho, Jongheon Shin, Sang Kook Lee, Sanghee Kim
The structure of wondonin marine natural products was renovated to attain new drug-like scaffolds. Wondonins have novel antiangiogenic properties without overt cytotoxicity. However, the chemical instability and synthetic complexity of wondonins have hindered their development as a new type of antiangiogenesis agent. Using a structure-based bioisosterism, the benzodioxole moiety was changed to benzothiazole, and the imidazole moiety was replaced by 1,2,3-triazole. Our efforts resulted in a new scaffold with enhanced antiangiogenic activity and minimized cytotoxicity...
October 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29049172/primary-cardiac-angiosarcoma-a-case-report
#19
Ruiping Zhang, Lu Li, Xinming Li, Yanlin Chu, Jihua Wu, Yunge Gao
BACKGROUND: Primary cardiac angiosarcoma is rare, but it is the most aggressive type of cardiac malignant tumor. When disease is confirmed it is often late in its stage resulting in a poor prognosis. CASE PRESENTATION: We reported a 52-year-old woman who complained of dyspnea for 2 months and dry cough for 10 days. Computed tomography (CT), F-fluorodeoxyglucose (F-FDG), positron emission tomography-computed tomography (PET-CT), and transthoracic echocardiography showed a space-occupying lesion 7 cm × 5 cm × 5 cm in the right atrium...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28993906/antiangiogenesis-and-medical-therapy-failure-in-intracranial-atherosclerosis
#20
Nestor R Gonzalez, Raymond Liou, Florian Kurth, Hao Jiang, Jeffrey Saver
Intracranial atherosclerotic disease (ICAD) is one of the most common causes of stroke worldwide and the one with the worst prognosis. In this study, we assessed the hypothesis that the balance of circulating pro- and antiangiogenic factors plays a role in the evolution of the disease and can be used as a potential marker for the disease course and a target for treatment. Seventy-four patients with severe ICAD were enrolled in this prospective observational study, medically optimized, and followed for 6 months...
October 9, 2017: Angiogenesis
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