keyword
https://read.qxmd.com/read/38536650/ifit1-modulates-the-proliferation-migration-and-invasion-of-pancreatic-cancer-cells-via-wnt-%C3%AE-catenin-signaling
#21
JOURNAL ARTICLE
Tian-Hao Li, Bang-Bo Zhao, Cheng Qin, Yuan-Yang Wang, Ze-Ru Li, Hong-Tao Cao, Xiao-Ying Yang, Xing-Tong Zhou, Wei-Bin Wang
OBJECTIVES: Previously, Interferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) has been shown to promote cancer development. Here, we aimed to explore the role of IFIT1 in the development and progression of pancreatic cancer, including the underlying mechanisms. METHODS: We explored IFIT1 expression in pancreatic cancer samples using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. Cell Counting Kit-8 (CCK8), colony formation, scratch wound-healing and Transwell assays were performed to assess the proliferation, migration and invasion abilities of pancreatic cancer cells...
March 27, 2024: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/38536631/the-importance-of-biomarker-testing-in-the-treatment-of-advanced-non-small-cell-lung-cancer-a-podcast
#22
JOURNAL ARTICLE
Fred R Hirsch, Chul Kim
The identification of actionable biomarkers and development of targeted therapies have revolutionized the field of lung cancer treatment. In patients with advanced non-small cell lung cancer (NSCLC), biomarker testing can inform selection of effective targeted therapies as well as avoid therapies that are less likely to be effective in certain populations. A growing number of actionable targets, including those involving EGFR, ALK, ROS1, BRAF, MET, KRAS, NTRK, RET, HER2, and PD-L1, can be identified with biomarker testing...
March 27, 2024: Oncology and Therapy
https://read.qxmd.com/read/38536624/validation-of-the-visionarray%C3%A2-chip-assay-for-hpv-dna-testing-in-histology-specimens-of-oropharyngeal-squamous-cell-carcinoma
#23
JOURNAL ARTICLE
Hani Ibrahim Channir, Simone Kloch Bendtsen, Linea Cecilie Melchior, Pia Rovsing Sandholm, Christine Mordhorst, Amanda-Louise Fenger Carlander, Christian von Buchwald, Katalin Kiss
BACKGROUND: The detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous cell carcinoma (OPSCC). The choice of HPV detection assay and testing algorithms differ across institutions and vary in cost, detection targets, technical feasibility, and turnaround time. In this study, we aimed to validate the VisionArray® HPV Chip for formalin-fixed and paraffin-embedded (FFPE) samples of OPSCC using the previously applied standard pan-HPV DNA PCR assay as a reference...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536591/circ_0020460-drives-tumorigenesis-in-cervical-cancer-through-mir-485-3p-sponging
#24
JOURNAL ARTICLE
Kun Yan, Chunyan Hu, Yali Cheng, Lingzhi Zheng, Baojin Zeng, Sujun Zhao, Chen Liu
Deregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the role of circ_0020460 in the development of cervical cancer (CC) and its potential mechanism of action. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were used to detect the expression levels of circ_0020460, miR-485-3p and C-X-C motif chemokine ligand 1 (CXCL1). The roles of circ_0020460 on cell proliferation, cell migration, cell invasion, cell apoptosis, and angiogenesis were investigated using cell counting kit-8 (CCK-8) and Ethynyl deoxyuridine (Edu) assay, wound healing assay, transwell assay, flow cytometry assay, and tube formation assay, respectively...
March 27, 2024: Discover. Oncology
https://read.qxmd.com/read/38536579/cell-cycle-related-protein-centromere-protein-f-deficiency-inhibits-cervical-cancer-cell-growth-by-inducing-ferroptosis-via-nrf2-inactivation
#25
JOURNAL ARTICLE
Xin Hui Tang, Tian Nan Zhao, Li Guo, Xin Yue Liu, Wei Na Zhang, Ping Zhang
Cervical cancer (CC) is one of the severe cancers that pose a threat to women's health and result in death. CENPF, the centromere protein F, plays a crucial role in mitosis by regulating numerous cellular processes, such as chromosome segregation during mitosis. According to bioinformatics research, CENPF serves as a master regulator that is upregulated and activated in cervical cancer. Nevertheless, the precise biological mechanism that CENPF operates in CC remains unclear. The aim of this study was to analyze the function of CENPF on cervical cancer and its mechanism...
March 27, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38536568/integration-of-single-cell-and-bulk-rna-seq-data-to-identify-the-cancer-associated-fibroblast-subtypes-and-risk-model-in-glioma
#26
JOURNAL ARTICLE
Xiuwei Yan, Xin Gao, Jiawei Dong, Fang Wang, Xiaoyan Jiang, Xueyan Hu, Jiheng Zhang, Nan Wang, Lei Xu, Zhihui Liu, Shaoshan Hu, Hongtao Zhao
Cancer-associated fibroblasts (CAFs) are an important component of the stroma. Studies showed that CAFs were pivotally in glioma progression which have long been considered a promising therapeutic target. Therefore, the identification of prognostic CAF markers might facilitate the development of novel diagnostic and therapeutic approaches. A total of 1333 glioma samples were obtained from the TCGA and CGGA datasets. The EPIC, MCP-counter, and xCell algorithms were used to evaluate the relative proportion of CAFs in glioma...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38536567/mir-374a-b-5p-suppresses-cell-growth-in-papillary-thyroid-carcinoma-through-blocking-exosomal-anxa1-induced-macrophage-m2-polarization
#27
JOURNAL ARTICLE
Sanbao Liu
Papillary thyroid carcinoma (PTC), comprising 85% of all thyroid cancers, is an epithelial malignancy. The potential for malignant transformation in normal cells by thyroid cancer cells via exosomal Annexin A1 (ANXA1) delivery is investigated in this study. Our aim is to determine the impact of PTC cells on macrophage polarization through exosomal ANXA1 secretion and its implications for tumor progression. Exosomes in PTC cells were examined using transmission electron microscopy, exosome labeling, and nanoparticle tracking analysis...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38536555/folate-induces-stemness-and-increases-oxygen-consumption-under-glucose-deprivation-by-notch-1-pathway-activation-in-colorectal-cancer-cell
#28
JOURNAL ARTICLE
Juan Rodríguez Silva, Matías Monsalves-Álvarez, Carlos Sepúlveda, Camila Donoso-Barraza, Rodrigo Troncoso, Sandra Hirsch
Evidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies...
March 27, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38536544/the-suppression-of-cell-motility-through-the-reduction-of-fak-activity-and-expression-of-cell-adhesion-proteins-by-hamscs-secretome-in-mda-mb-231-breast-cancer-cells
#29
JOURNAL ARTICLE
Fatemeh Safari, Setareh Bararpour, Fatemeh Omidi Chomachaei
Breast cancer is a leading cause of death in women worldwide. Cancer therapy based on stem cells is considered as a novel and promising platform. In the present study, we explore the therapeutic effects of human amniotic mesenchymal stromal cells (hAMSCs) through the reduction of focal adhesion kinase (FAK) activity, SHP-2, and cell adhesion proteins such as Paxillin, Vinculin, Fibronectin, Talin, and integrin αvβ3 expression in MDA-MB-231 breast cancer cells. For this purpose, we employed a co-culture system using 6-well plate transwell...
March 27, 2024: Investigational New Drugs
https://read.qxmd.com/read/38536543/effect-of-early-dose-reduction-of-osimertinib-on-efficacy-in-the-first-line-treatment-for-egfr-mutated-non-small-cell-lung-cancer
#30
JOURNAL ARTICLE
Tomoki Hori, Kazuhiro Yamamoto, Takefumi Ito, Shigeki Ikushima, Tomohiro Omura, Ikuko Yano
Osimertinib is used as the first-line therapy for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, early dose reduction is often required due to adverse events (AEs). This study aimed to evaluate the effect of early dose reduction of osimertinib on efficacy and safety. This was a retrospective study including patients with EGFR-mutated NSCLC who were started on osimertinib as the first-line therapy between August 2018 and December 2021. Patients whose doses were reduced to less than 80 mg/day within 6 months of osimertinib initiation or started at 40 mg/day were defined as the dose reduction group...
March 27, 2024: Investigational New Drugs
https://read.qxmd.com/read/38536540/palbociclib-inhibits-the-progression-of-head-and-neck-cancer-and-improves-the-cetuximab-response-under-specific-condition-in-vitro-and-in-vivo
#31
JOURNAL ARTICLE
Ruichen Li, Qi Wang, Yang Zhao, Yi Zhu, Xiaoshen Wang
BACKGROUND: In head and neck squamous cell carcinoma (HNSCC) with human papillomavirus (HPV)-negative, deregulation of cell cycle is partly due to inactivation of p16INK4 and overexpression of cyclin D1. Here we investigated the in vitro and in vivo effects of the CDK4/6 inhibitor Palbociclib alone or combined with EGFR inhibitor Cetuximab in HNSCC. METHODS AND RESULTS: CCK-8, soft agar assay, colony formation assay, wound healing assay and transwell assay, β-galactosidase assay, western blotting, and cell-derived xenografts were used to investigated the in vitro and in vivo activity of drugs...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536527/does-the-time-interval-from-neoadjuvant-camrelizumab-combined-with-chemotherapy-to-surgery-affect-outcomes-for-locally-advanced-esophageal-squamous-cell-carcinoma
#32
JOURNAL ARTICLE
Jiacong Liu, Linhai Zhu, Xuhua Huang, Zhongjie Lu, Yanye Wang, Yuhong Yang, Jiayue Ye, Chen Gu, Wang Lv, Chong Zhang, Jian Hu
BACKGROUND: There is currently no consensus on the optimal interval time between neoadjuvant therapy and surgery, and whether prolonged time interval from neoadjuvant therapy to surgery results in bad outcomes for locally advanced esophageal squamous cell carcinoma (ESCC). In this study, we aim to evaluate outcomes of time intervals ≤ 8 weeks and > 8 weeks in locally advanced ESCC. METHODS: This retrospective study consecutively included ESCC patients who received esophagectomy after neoadjuvant camrelizumab combined with chemotherapy at the Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine...
March 27, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38536512/potential-role-of-immune-cell-therapy-in-gynecological-cancer-and-future-promises-a-comprehensive-review
#33
REVIEW
Sandipan Dasgupta, Sakuntala Gayen, Tania Chakraborty, Naureen Afrose, Ranita Pal, Sutapa Mahata, Vilas Nasare, Souvik Roy
Gynecological malignancies are most leading causes of death among women worldwide. The high prevalence of gynecologic malignancies remains significant, necessitating to turn the novel treatment approach like immunotherapy, wherein cancer cells are killed by the invasion of immune system. In recent year, immunotherapy has mostly an advanced treatment approach to repressing the tumor cells survival, proliferation, and invasion via the activation of immune systems. Moreover, various types of immune cells including T-cells, B-cells, and dendritic cells are associated with the immunotherapeutic strategy in cancer treatment...
March 27, 2024: Medical Oncology
https://read.qxmd.com/read/38536494/the-role-of-na-coupled-bicarbonate-transporters-ncbt-in-health-and-disease
#34
REVIEW
Shannon R Holmberg, Yohei Sakamoto, Akira Kato, Michael F Romero
Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO3 - ) transporters consists of ten members, sorted by their coupling to either sodium (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE), chloride (AE1, AE2, AE3), or borate (BTR1). The ionic coupling of SLC4A9 (AE4) remains controversial...
March 27, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38536483/cacna2d1-regulates-the-progression-and-influences-the-microenvironment-of-colon-cancer
#35
JOURNAL ARTICLE
Hiroyuki Inoue, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Yoshiaki Kuriu, Takeshi Kubota, Hitoshi Fujiwara, Yukiko Morinaga, Eiichi Konishi, Eigo Otsuji
BACKGROUND: Calcium voltage-gated channel auxiliary subunit alpha 2/delta 1 (CACNA2D1), a gene encoding a voltage-gated calcium channel, has been reported as an oncogene in several cancers. However, its role in colon cancer (CC) remains unclear. This study aimed to investigate the function of CACNA2D1 and its effect on the microenvironment in CC. METHODS: Immunohistochemistry (IHC) analysis was performed on samples collected from 200 patients with CC who underwent curative colectomy...
March 27, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38536443/a-polo-like-kinase-1-inhibitor-enhances-erastin-sensitivity-in-head-and-neck-squamous-cell-carcinoma-cells-in-vitro
#36
JOURNAL ARTICLE
Xiangping Wu, Jing Wu
BACKGROUND: Polo-like kinase 1 (PLK1) is a critical therapeutic target in the treatment of head and neck squamous cell carcinoma (HNSCC). The objective of this study was to investigate the therapeutic effect of the combination of BI 2536, a PLK1 inhibitor, and erastin, a ferroptosis inducer, in HNSCC. METHODS: The proliferation, invasion, and migration abilities of Tu177 and FaDu cells upon exposure to BI 2536 and erastin, used in combination or alone, were tested...
March 27, 2024: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38536434/the-analysis-of-boric-acid-effect-on-epithelial-mesenchymal-transition-of-cd133%C3%A2-%C3%A2-cd117%C3%A2-%C3%A2-lung-cancer-stem-cells
#37
JOURNAL ARTICLE
Tuğba Semerci Sevimli, Murat Sevimli, Aynaz Ghorbani, Varol Şahintürk, Emilia Qomi Ekenel, Tuğba Ertem, Bahar Demir Cevizlidere, Burcugül Altuğ, Özlem Tomsuk, Onur Uysal, Sibel Güneş Bağış, Hüseyin Avci, Fatih Çemrek, Zarifa Ahmadova
Targeting lung cancer stem cells (LC-SCs) for metastasis may be an effective strategy against lung cancer. This study is the first on epithelial-mesenchymal transition (EMT) properties of boric acid (BA) in LC-SCs. LC-SCs were isolated using the magnetic cell sorting (MACS) method. Tumor-sphere formation and flow cytometry confirmed CSC phenotype. The cytotoxic effect of BA was measured by MTT analysis, and the effect of BA on EMT was examined by migration analysis. The expression levels of ZEB1, SNAIL1, ITGA5, CDH1, ITGB1, VIM, COL1A1, and LAMA5 genes were analyzed by RT-qPCR...
March 27, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38536425/integrated-pretreatment-diffusion-kurtosis-imaging-and-serum-squamous-cell-carcinoma-antigen-levels-a-biomarker-strategy-for-early-assessment-of-radiotherapy-outcomes-in-cervical-cancer
#38
JOURNAL ARTICLE
Xiang Zheng, Fangmin Shen, Wenjuan Chen, Wang Ren, Shaoliang Tang
OBJECTIVE: This study aims to explore the utility of pretreatment DKI parameters and serum SCC-Ag in evaluating the early therapeutic response of cervical cancer to radiotherapy. MATERIALS AND METHODS: A total of 33 patients diagnosed with cervical cancer, including 31 cases of cervical squamous cell carcinoma and two cases of adenosquamous carcinoma, participated in the study. All patients underwent conventional MRI and DKI scans on a 3T magnetic resonance scanner before radiotherapy and after ten sessions of radiotherapy...
March 27, 2024: Abdominal Radiology
https://read.qxmd.com/read/38536408/building-synthetic-biosensors-using-red-blood-cell-proteins
#39
JOURNAL ARTICLE
Taylor B Dolberg, Taylor F Gunnels, Te Ling, Kelly A Sarnese, John D Crispino, Joshua N Leonard
As the use of engineered cell therapies expands from pioneering efforts in cancer immunotherapy to other applications, an attractive but less explored approach is the use of engineered red blood cells (RBCs). Compared to other cells, RBCs have a very long circulation time and reside in the blood compartment, so they could be ideally suited for applications as sentinel cells that enable in situ sensing and diagnostics. However, we largely lack tools for converting RBCs into biosensors. A unique challenge is that RBCs remodel their membranes during maturation, shedding many membrane components, suggesting that an RBC-specific approach may be needed...
March 27, 2024: ACS Synthetic Biology
https://read.qxmd.com/read/38536233/integrative-methylome-and-transcriptome-analysis-reveals-epigenetic-regulation-of-fusobacterium-nucleatum-in-laryngeal-cancer
#40
JOURNAL ARTICLE
Xiaohui Yuan, Hui-Ching Lau, Huiying Huang, Chi-Yao Hsueh, Hongli Gong, Liang Zhou
The aetiological mechanisms of Fusobacterium nucleatum in laryngeal cancer remain unclear. This study aimed to reveal the epigenetic signature induced by F. nucleatum in laryngeal squamous cell carcinoma (LSCC). Combined analysis of methylome and transcriptome data was performed to address the functional role of F. nucleatum in laryngeal cancer. Twenty-nine differentially expressed methylation-driven genes were identified by mapping the methylation levels of significant differential methylation sites to the expression levels of related genes...
March 2024: Microbial Genomics
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