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https://www.readbyqxmd.com/read/29449724/angiomyofibroblastoma-of-the-spermatic-cord-a-case-report
#1
L Bouhajja, S A Rammeh, S Sayari, R Zermani, F Farah
Angiomyofibroblastoma (AMF) is a rare benign mesenchymal tumor with tendency to arise in the lower genital tract of middleaged women, predominately in the vulva. A few cases of AMF in males have been reported involving the scrotum, perineum or spermatic cord. We report a new case of AMF arising in the right inguinal region of a 27-year-old man. The tumor was well-circumscribed, myxoid and measured 30 mm in maximum dimension. On microscopic examination, the tumor was composed of spindle cells without atypia and with less than one mitosis figure per 10 high-power fields...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29445571/immunoreactivity-of-wilms-tumor-1-wt1-as-an-additional-evidence-supporting-hemangiomatous-rather-than-inflammatory-origin-in-the-etiopathogenesis-of-angiolymphoid-hyperplasia-with-eosinophilia
#2
Fatma Tokat, Julia S Lehman, Engin Sezer, Emel Dikicioglu Cetin, Umit Ince, Emel Ozturk Durmaz
Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process. Aim: Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities...
January 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29443783/giant-gist-of-the-stomach-a-successful-case-of-safe-resection-with-preoperative-simulation-using-three-dimensional-ct-angiography-case-report
#3
Kentaro Matsuo, Masaya Inoue, Yasutsugu Shirai, Tatsuki Kataoka, Shuji Kagota, Kohei Taniguchi, Sang-Woong Lee, Kazuhisa Uchiyama
RATIONALE: We report a very rare case of safely resectable giant gastrointestinal stromal tumor (GIST) with preoperative three-dimensional computed tomography (3D-CT) angiography in spite of no neoadjuvant treatment. PATIENT'S CONCERN: A 71-year-old woman presented to our hospital with an abdominal giant tumor. As this giant tumor could not be accurately diagnosed by preoperative investigation, we had to perform her surgical treatment without neoadjuvant treatment...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29440916/overexpression-of-zwint-predicts-poor-prognosis-and-promotes-the-proliferation-of-hepatocellular-carcinoma-by-regulating-cell-cycle-related-proteins
#4
Hanning Ying, Zhiyao Xu, Mingming Chen, Senjun Zhou, Xiao Liang, Xiujun Cai
Introduction: Zwint, a centromere-complex component required for the mitotic spindle checkpoint, has been reported to be overexpressed in different human cancers, but it has not been studied in human hepatocellular carcinoma (HCC). Materials and methods: The role of Zwint in hepatocellular carcinoma cell proliferation capacities was evaluated by using cell counting kit-8 (CCK8), flow cytometry, clone formation and tumor formation assay in nude mice. Western blot analysis and qPCR assay were performed to assess Zwint interacting with cell-cycle-related proteins...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29438169/superficial-solitary-fibrous-tumor-a-series-of-26-cases
#5
Patrick Feasel, Alyaa Al-Ibraheemi, Karen Fritchie, Riyam T Zriek, Wei-Lien Wang, Elizabeth Demicco, Marcela Saeb-Lima, John R Goldblum, Brian P Rubin, Jesse K McKenney, Jennifer S Ko, Steven D Billings
While superficial (cutaneous/subcutaneous) solitary fibrous tumor (SFT) have been described, definitive diagnosis is difficult due to overlapping features with other tumors. We describe the largest series to date of superficial SFT. For inclusion, SFT had to arise in dermis or subcutis. Twenty-six cases were identified. Patients ranged from 16 to 80 years (mean, 47 y) with a marked female predominance (19 F; 7 M). Tumors involved the head (11), thigh (7), back (3), shoulder (2), upper arm (1), ankle (1), and great toe (1)...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29435157/the-microtubule-associated-protein-prc1-is-a-potential-therapeutic-target-for-lung-cancer
#6
Steffen Hanselmann, Patrick Wolter, Jonas Malkmus, Stefan Gaubatz
In this study, we investigated whether proteins that are involved in cytokinesis are potential targets for therapy of lung cancer. We find that the microtubule-associated protein PRC1 (protein required for cytokinesis 1), which plays a key role in organizing anti-parallel microtubule in the central spindle in cytokinesis, is overexpressed in lung cancer cell lines compared to normal cells. Increased expression of PRC1 is correlated with a poor prognosis of human lung adenocarcinoma patients. Lentiviral delivered, inducible RNAi of PRC1 demonstrated that proliferation of lung cancer cell lines strongly depends on PRC1...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435023/primary-malignant-perivascular-epithelioid-cell-neoplasm-pecoma-of-the-bone-mimicking-granular-cell-tumor-in-core-biopsy-a-case-report-and-literature-review
#7
Sam Sadigh, Preya Shah, Kristy Weber, Ronnie Sebro, Paul J Zhang
The present study investigated the case of a 46-year-old female with primary malignant perivascular epithelioid cell neoplasm (PEComa) of the femur. The patient presented with a 5-month history of right distal thigh pain following trauma. Radiographs of the right distal femur revealed a mixed lytic and sclerotic lesion with subtle areas of cortical destruction and soft tissue extension, consistent with an aggressive tumor. A core biopsy revealed an epithelioid tumor with granular cell features, but a definitive diagnosis could not be made...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434495/carcinosarcoma-of-stomach-confined-to-the-mucosa
#8
Hirohiko Kuroda, Hiroaki Saito, Yusuke Kono, Yuki Murakami, Yuji Shishido, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Kanae Nosaka, Yoshihisa Umekita, Yoshiyuki Fujiwara
Carcinosarcoma is a malignant tumor composed of both epithelial and mesenchymal malignant tumor components. A 78-year-old man was transferred to our hospital because of hematemesis and tarry stool. An emergency gastrointestinal endoscopic examination revealed active bleeding from an ulcerative lesion on the posterior wall of the gastric body; endoscopic hemostasis was successfully performed. A gastrointestinal endoscopy performed two months later showed a polypoid lesion at the same place where the ulcer had been...
December 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/29434041/polo-like-kinase-4-inhibition-produces-polyploidy-and-apoptotic-death-of-lung-cancers
#9
Masanori Kawakami, Lisa Maria Mustachio, Lin Zheng, Yulong Chen, Jaime Rodriguez-Canales, Barbara Mino, Jonathan M Kurie, Jason Roszik, Pamela Andrea Villalobos, Kelsie L Thu, Jennifer Silvester, David W Cescon, Ignacio I Wistuba, Tak W Mak, Xi Liu, Ethan Dmitrovsky
Polo-like kinase 4 (PLK4) is a serine/threonine kinase regulating centriole duplication. CFI-400945 is a highly selective PLK4 inhibitor that deregulates centriole duplication, causing mitotic defects and death of aneuploid cancers. Prior work was substantially extended by showing CFI-400945 causes polyploidy, growth inhibition, and apoptotic death of murine and human lung cancer cells, despite expression of mutated KRAS or p53. Analysis of DNA content by propidium iodide (PI) staining revealed cells with >4N DNA content (polyploidy) markedly increased after CFI-400945 treatment...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29429243/-experimental-studies-on-correlation-between-nucleolus-spindle-related-protein-1-and-the-malignant-progression-and-prognosis-of-human-glioblastoma-multiforme
#10
Y P Xue, X Y Ji, L Yang, H R Liu, Y J Sheng, X X Dai, Y J Xi, J C Liu, J Shi, T Xie, Y S Zhang, J W Ma, J Dong
Objective: To investigate the correlation between nucleolus spindle-related protein 1 (NUSAP1) and malignant progression and prognosis of human glioblastoma multiforme (GBM). Methods: RT-PCR and immunohistochemical technique were applied to analyze NUSAP1 expression level in GBM surgical specimens. Correlations between NUSAP1 expression and molecular classification and survival of patients with GBM were also investigated in TCGA database. The gene silencing technique was used to silence NUSAP1 expression in U87 cells, CCK-8 assay was used to detect cell proliferation, flow cytometry was used to detect cell cycle changes, and in vivo tumorigenicity was evaluated after NUSAP1 silencing in tumor-bearing mice...
January 30, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29429162/-pulmonary-microcystic-fibromyxoma-report-of-a-case-with-review-of-literature
#11
Q X Gong, H Li, Z H Zhang, Q H Fan
Objective: To study the clinicopathologic features, diagnosis and differential diagnosis of pulmonary microcystic fibromyxoma. Methods: In March 2014, at the First Affiliated Hospital to Nanjing Medical University a 58-year-old female patient of pulmonary microcystic fibromyxoma was collected. The clinicopathologic, immunohistochemical and genetic profile of a case of pulmonary microcystic fibromyxoma were studied, and the relevant literature reviewed. Results: The patient was a 58-year-old female who presented with cough and sputum for 1 month...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29429160/-clinicopathologic-features-of-atypical-spindle-cell-lipomatous-tumor
#12
M Zhao, Y B Wang, Y J Yan, W Wang, G Q Ru, X L He
Objective: To investigate the clinicopathologic characteristics, immunophenotype, differential and diagnostic features of atypical spindle cell lipomatous tumor (ASLT). Methods: Three cases of ASLT were collected from January 2010 to March 2017 at Zhejiang Provincial People's Hospital. The clinical and imaging features, histomorphology, immunophenotype and prognosis were analyzed. Fluorescence in situ hybridization (FISH) was used to detect MDM2 gene amplification, and relevant literature was reviewed. Results: All three patients were adult males, aged 38, 43 and 54 years, respectively...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29429159/-retroperitoneal-dedifferentiated-liposarcoma-with-rhabdomyoblastic-differentiation-a-clinicopathological-analysis
#13
L Liu, L H Wang, Y B Ren, X S Rao, S M Yang
Objective: To investigate the clinicopathological features, differential diagnosis, treatment and prognosis of dedifferentiated liposarcoma with rhabdomyoblastic differentiation. Methods: Six cases of retroperitoneal dedifferentiated liposarcoma with rhabdomyoblastic features were collected from December 2014 to August 2017 at Peking University International Hospital. The clinical manifestations, histomorphology, immunophenotype, treatment and follow-up data were analyzed, and relevant literature reviewed. Results: The six patients included two males and four females, with age range of 47 to 66 years (mean 56 years)...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29429158/-pleomorphic-and-dedifferentiated-leiomyosarcoma-a-clinicopathologic-analysis
#14
M Sun, J G Liu, Q Y Weng, L Yu, J Wang
Objective: To investigate the clinicopathologic features, differential diagnosis and biological behavior of pleomorphic leiomyosarcoma (PLMS) and dedifferentiated leiomyosarcoma (DLMS). Methods: Forty-nine cases were collected from November 2007 to December 2016, including eight that diagnosed at Fudan University Shanghai Cancer Center, and 41 consultation cases. The clinical findings and pathologic features were reviewed. Immunophenotype was obtained in 33 cases and follow-up information was available in 38 cases...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29423163/metastatic-epicardial-leiomyoma-with-uncertain-malignant-potential
#15
Miroslav P Peev, Anne Therese C Lim, Tianle Zou, Laurence H Brinckerhoff
A 49-year-old female with history of uterine leiomyoma and intermittent shortness of breath presented to the emergency department with new onset of tachycardia and chest pain. Subsequent cardiac work up revealed hypoechoic mass compressing the right ventricle. Computer tomography guided biopsy for tissue characterization revealed a benign spindle cell tumor. Surgical resection of a large epicardial tumor was undertaken. The histologic examination of the tumor was consistent with Estrogen and Progesterone positive leiomyoma of uncertain malignant potential...
September 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29420837/carcinosarcoma-mimicking-a-feline-injection-site-sarcoma-in-a-cat
#16
Rafał Sapierzyński
A 15-year-old spayed female domestic short-haired cat with cutaneous/subcutaneous well-circumscribed, alopecic mass approximately 25 × 30 mm in diameter, localized to the left shoulder region was brought to the veterinary surgery department. Despite the suggestive location and macroscopic appearance, feline injection-site sarcoma was not suspected based on the cytologic examination of fine-needle aspirates. The tumor was surgically resected, and tissue sections were evaluated microscopically. The tumor was found to be nonencapsulated with a distinct border between the neoplastic parenchyma and surrounding connective tissue...
February 8, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29416169/effect-of-intravenous-zoledronic-acid-on-histopathology-and-recurrence-after-extended-curettage-in-giant-cell-tumors-of-bone-a-comparative-prospective-study
#17
Zile Singh Kundu, Rajeev Sen, Ankur Dhiman, Pankaj Sharma, Ramchander Siwach, Parveen Rana
Background: Giant cell tumor (GCT) of the bone is known for its locally aggressive behavior and tendency to recur. It is an admixture of rounded or spindle-shaped mononuclear neoplastic stromal cells and multinucleated osteoclast-like giant cells with their proportionate dispersion among the former. Zoledronic acid (a bisphosphonate) is being used in various cancers such as myelomas and metastasis, for osteoporosis with an aim to reduce the resorption of bone, and as an adjuvant treatment for the management of GCT of bone for reduction of local recurrence...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29413661/differential-diagnosis-of-benign-spindle-cell-lesions
#18
REVIEW
Gaetano Magro
Spindle cell lesions of the breast cover a wide spectrum of diseases ranging from reactive tumor-like lesions to high-grade malignant tumors. The recognition of the benign spindle cell tumor-like lesions (nodular fasciitis; reactive spindle cell nodule after biopsy, inflammatory pseudotumor/inflammatory myofibroblastic tumor; fascicular variant of pseudoangiomatous stromal hyperplasia) and tumors (myofibroblastoma, benign fibroblastic spindle cell tumor, leiomyoma, schwannoma, spindle cell lipoma, solitary fibrous tumor, myxoma) is crucial to avoid confusion with morphologically similar but more aggressive bland-appearing spindle cell tumors, such as desmoid-type fibromatosis, low-grade (fibromatosis-like) spindle cell carcinoma, low-grade fibrosarcoma/myofibroblastic sarcoma and dermatofibrosarcoma protuberans...
March 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29410603/the-expression-of-mdm2-in-gastrointestinal-stromal-tumors-immunohistochemical-analysis-of-35-cases
#19
Boubacar Efared, Gabrielle Atsame-Ebang, Layla Tahiri, Ibrahim Sory Sidibé, Fatimazahra Erregad, Nawal Hammas, Samia Arifi, Ihsane Mellouki, Abdelmalek Ousadden, Khalid Mazaz, Hinde El Fatemi, Laila Chbani
Background: Gastrointestinal stromal tumors (GIST) are the most common primary mesenchymal tumors of the digestive system. The assessment of their biological behavior still remains a scientific challenge. To date, there are no well-established biological prognostic markers of GIST. Our aim is to study the expression of the MDM2 oncoprotein in GIST through an immunohistochemical analysis. Methods: It was a retrospective study of 35 cases of GIST diagnosed from 2009 to 2012 in the department of pathology of Hassan II university hospital, Fès, Morocco...
2018: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29410491/an-expanded-immunohistochemical-profile-of-osteoclast-rich-undifferentiated-carcinoma-of-the-urinary-tract
#20
Salvatore F Priore, Lauren E Schwartz, Jonathan I Epstein
Osteoclast-rich undifferentiated carcinoma of the urinary tract (ORUCUT) is a rare tumor composed of ovoid to spindle-shaped mononuclear cells with intermixed or focally clustered osteoclast-like giant cells. Previous studies have demonstrated that the mononuclear cells are neoplastic cells, while the giant cells are reactive cells of histiocytic lineage. The association between these tumors and classic urothelial carcinomas suggest that the mononuclear cells are derived from urothelial cells; however, no studies have been conducted to assess the immunohistochemical profile of ORUCUT with more specific urothelial markers...
February 6, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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