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spindle cell tumor

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https://www.readbyqxmd.com/read/29921303/a-rare-case-of-perivascular-epithelioid-cell-tumor-pecoma-of-the-greater-omentum
#1
Koichi Okamoto, Yuka Okada, Kohei Ohno, Takahiro Yagi, Mitsuo Tsukamoto, Takuya Akahane, Ryu Shimada, Tamuro Hayama, Takeshi Tsuchiya, Keijiro Nozawa, Keiji Matsuda, Tsuyoshi Ishida, Fukuo Kondo, Yojiro Hashiguchi
BACKGROUND: A tumor composed exclusively or predominantly of human melanin black 45 (HMB45)-positive epithelioid cells is called a perivascular epithelioid cell tumor (PEComa). We report a very rare case of a PEComa of the greater omentum. CASE PRESENTATION: MRI conducted to examine the orthopedic disease of the patients, a 49-year-old Japanese woman, also identified a tumor in her pelvis. A CT scan revealed a tumor mass on the right side of the pelvic floor and clear nutrient vessels originating from the splenic and celiac arteries...
June 19, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29915791/spindle-cell-pseudotumor-mimicking-malignancy-in-an-immunocompetent-patient-with-a-left-ventricular-assist-device
#2
Zahava C Farkas, Lavneet Chawla, Shalom Frager, Edward Esses, Yasmin Yusuf, Brad Dworkin
Cytomegalovirus (CMV)-induced pseudotumors, or mass-like lesions in the colon, are a rare entity. We report a case of CMV-related spindle cell pseudotumor in an immunocompetent patient with a left ventricular assist device. This case highlights the importance of considering CMV-induced inflammatory pseudotumor when evaluating tumorous lesions in the colon, as well as the importance of appropriate diagnostic work-up, including proper biopsy technique and meticulous review of the pathology.
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29912718/pulmonary-sarcomatoid-carcinomas-a-review
#3
Annikka Weissferdt
Pulmonary sarcomatoid carcinomas belong to a group of neoplasms that remain incompletely understood. They are rare tumors of the bronchopulmonary system that incorporate a wide range of neoplasms that by definition contain a sarcomatoid component characterized by spindle or giant cells. Such classification has led to a heterogenous tumor category that includes neoplasms with different clinical, morphologic, and prognostic features. To date, the histopathologic diagnosis of pulmonary sarcomatoid carcinomas does not require the use of ancillary testing and is based on light microscopic criteria alone...
June 15, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29912715/ectomesenchymal-chondromyxoid-tumor-a-neoplasm-characterized-by-recurrent-rreb1-mkl2-fusions
#4
Brendan C Dickson, Cristina R Antonescu, Prokopios P Argyris, Elizabeth A Bilodeau, Martin J Bullock, Paul D Freedman, Douglas R Gnepp, Richard C Jordan, Ioannis G Koutlas, Cheng-Han Lee, Iona Leong, Mihai Merzianu, Bibianna M Purgina, Lester D R Thompson, Bret Wehrli, John M Wright, David Swanson, Lei Zhang, Justin A Bishop
Ectomesenchymal chondromyxoid tumor is a rare and benign neoplasm with a predilection for the anterior dorsal tongue. Despite morphologic heterogeneity, most cases are characterized by a proliferation of bland spindle cells with a distinctive reticular growth pattern and myxoid stroma. The immunophenotype of these neoplasms is likewise variable; most cases express glial fibrillary acid protein and S100 protein, with inconsistent reports of keratin and myoid marker expression. The molecular pathogenesis is poorly understood; however, a subset of cases has been reported to harbor EWSR1 gene rearrangement...
June 15, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29911532/melanoma-of-the-nasal-cavity
#5
Anissa Zaouak, Houda Hammami, Raja Jouini, Mariem Belhaj Salah, Achraf Debbiche, Samy Fenniche
78-year-old man presented with complaints of progressive nasal blockage and epistaxis over the previous 2 months. Clinical examination revealed a nodular, polypoid, ulcerated nonpigmented tumor filling the right nasal cavity (Figure 1). A punch biopsy was taken from the mass for histopathologic examination, which revealed many melanocytes in the submucosa. The stroma contained large numbers of spindle-shaped cells with hyperchromatic spindleoid nuclei (Figure 2), confirming the diagnosis of malignant melanoma...
2018: Skinmed
https://www.readbyqxmd.com/read/29909903/systemic-therapy-in-non-conventional-cancers-of-the-larynx
#6
REVIEW
Elaine Tan, Mayur D Mody, Nabil F Saba
Laryngeal cancer (LC) remains a challenging disease to treat. The majority of LCs diagnosed worldwide are squamous cell carcinomas (SCC), and current treatment guidelines are designed to address conventional laryngeal SCC. However, several histologically rare tumor types can originate in the larynx. There is a lack of guidelines regarding the best therapeutic approaches to these tumors and their treatment is often modeled after their recommended management at non-laryngeal sites. Understanding the role for systemic therapy in these rare tumors is important, especially for patients with advanced disease or those who are not surgical candidates...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29906007/myopericytoma-in-an-unusual-location
#7
Leon Felipe Ruiz-Arriaga, Ana Laura Ramirez Teran, Carlos Ortiz-Hidalgo, Veronica Fonte-Avalos, Sonia Toussaint-Caire, Ma Elisa Vega-Memije, Mariana CatalinaDe Anda-Juarez
Myopericytoma is a soft-tissue tumor of perivascular cells (pericytes). It is slow-growing, usually asymptomatic, and generally benign, although a malignant variant has been described. The etiology is unknown, but it has been associated with local trauma. The most common location is on the distal extremities. Histologically, it is characterized by a well-circumscribed, non-encapsulated proliferation of spindle shaped cells similar to myofibroblasts with oval nuclei and eosinophilic cytoplasm, arranged in perivascular concentric rings...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29903910/aberrant-endocytosis-leads-to-the-loss-of-normal-mitotic-spindle-orientation-during-epithelial-glandular-morphogenesis
#8
James W Clancy, Colin S Sheehan, Christopher J Tricarico, Crislyn D'Souza-Schorey
Epithelial cells form tissues with many functions, including secretion and environmental separation and protection. Glandular epithelial tissues comprise of cysts and tubules that are formed from a polarized, single-epithelial cell layer surrounding a central, fluid-filled lumen. The pathways regulating key processes in epithelial tissue morphogenesis such as mitotic spindle formation are incompletely understood, but are important to investigate, as their dysregulation is a signature of epithelial tumors. Here, we describe a signaling axis that manifests in a defect in mitotic spindle orientation during epithelial growth and cystogenesis...
June 14, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29901613/a-rare-case-of-primary-small-bowel-de-differentiated-liposarcoma-causing-intussusception-a-case-report
#9
Kentaro Matsuo, Masaya Inoue, Yasutsugu Shirai, Tatsuki Kataoka, Shuji Kagota, Kohei Taniguchi, Sang-Woong Lee, Kazuhisa Uchiyama
RATIONALE: Liposarcoma (LPS) is a relatively rare malignant soft tissue tumor. Management of LPS including diagnosis is difficult, because it has no characteristic symptoms and no established effective treatment. Herein we reported an extremely rare case of intussusception induced by primary small bowel LPS. PATIENT'S CONCERN: A-84-year-old male was a consult to our Emergency Department with symptoms of a terrible general fatigue, abdominal pain, and vomiting. DIAGNOSIS: Abdominal ultrasonography and computed tomography (CT) revealed probable intussusception...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901569/clinicopathologic-features-of-a-series-of-primary-renal-cic-rearranged-sarcomas-with-comprehensive-molecular-analysis
#10
Shamlal Mangray, David R Kelly, Sophie LeGuellec, Eddie Fridman, Sangeeta Aggarwal, Mary Shago, Andres Matoso, Russell Madison, Sharmila Pramanik, Shan Zhong, Rong Li, Kara A Lombardo, Stuart Cramer, Joseph Pressey, Jeffrey S Ross, Robert J Corona, Gennady Bratslavsky, Pedram Argani, Jean-Michel Coindre, Gino R Somers, Siraj M Ali, Evgeny Yakirevich
CIC-rearranged sarcomas rarely occur in visceral organs including the kidney. The most common fusion partner with CIC is the DUX4 gene, but variant fusion partners have also been reported. Herein, we describe the clinicopathologic features and comprehensive molecular profiling of 4 cases of primary renal CIC-rearranged sarcomas. All cases occurred in females, age range 13 to 82 years and included 3 resections and 1 needle biopsy specimen. There was a tendency for development of metastatic disease predominantly to the lungs and poor disease outcome despite different treatment strategies...
June 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29900760/anaplastic-lymphoma-kinase-negative-uterine-inflammatory-myofibroblastic-tumor-containing-the-etv6-ntrk3-fusion-gene-a-case-report
#11
Akimasa Takahashi, Manabu Kurosawa, Mao Uemura, Jun Kitazawa, Yoshihiko Hayashi
Inflammatory myofibroblastic tumors (IMTs) are neoplasms with low malignant potential, and the most common tumor in the lung and orbit. Their occurrence in the uterus is rare. Approximately 50% of IMT patients have anaplastic lymphoma kinase gene ( ALK) rearrangements. Recent studies described novel fusions involving ROS1, platelet-derived growth factor receptor beta ( PDGFR-β), and ETS translocation variant ( ETV6) genes in a subset of ALK-negative patients. We report a 44-year-old woman with anemia and uterine IMT...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29899989/myoepithelial-carcinoma-of-the-parotid-gland-a-case-of-adequate-fine-needle-aspiration-cytology-specimens-rendering-a-conclusive-diagnosis-possible
#12
Xin Guo, Jiro Watanabe, Sanae Ariyasu, Yasuyuki Sasaguri, Nozomu Kurose, Kei Fukushima, Sohsuke Yamada
An 80-year-old male presented with a history of a hard right parotid mass that had gradually increased in size, with subsequent facial paralysis. A fine-needle aspiration biopsy was performed. The cytologic specimens contained a substantial number of sheet-like clusters or small groups of a mixture of plasmacytoid, oval to spindled, or large epithelioid cells having hyperchromatic pleomorphic nuclei, abundant cytoplasm with occasional inclusion body-like materials, and prominent nucleoli, in a relatively clear background...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29899846/conception-synthesis-and-characterization-of-a-rofecoxib-combretastatin-hybrid-drug-with-potent-cyclooxygenase-2-cox-2-inhibiting-and-microtubule-disrupting-activities-in-colon-cancer-cell-culture-and-xenograft-models
#13
Surendra R Punganuru, Hanumantha Rao Madala, Constantinos M Mikelis, Anshuman Dixit, Viswanath Arutla, Kalkunte S Srivenugopal
Tumor heterogeneity and drug resistance pose severe limitations to chemotherapy of colorectal cancers (CRCs) necessitating innovative approaches to trigger multiple cytocidal events for increased efficacy. Here, we developed a hybrid drug called KSS19 by combining the COX-2 selective NSAID rofecoxib with the cis-stilbene found in combretastatin A4 (CA4), a problematic, but potent antimicrotubule and anti-angiogenesis agent. The structural design of KSS19 completely prevented the isomerization of CA4 its biologically inactive trans-form...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29899304/validation-of-different-nutritional-assessment-tools-in-predicting-prognosis-of-patients-with-soft-tissue-spindle-cell-sarcomas
#14
Hiromi Sasaki, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi, Takao Setoguchi
Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional assessment systems, including Glasgow prognostic score (GPS), Geriatric Nutritional Risk Index (GNRI), neutrophil⁻lymphocyte ratio (NLR), platelet⁻lymphocyte ratio (PLR), and controlling nutritional (CONUT) score against outcomes in 103 patients with STS, of whom 15 (14.6%) died within 1 year of diagnosis. GPS, GNRI, NLR, PLR, and CONUT scores significantly differed between patients who died within one year and patients who lived longer...
June 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29898011/inflammatory-myofibroblastic-tumor-of-the-prostate-after-transurethral-resection-of-the-prostate-with-negative-expression-of-anaplastic-lymphoma-kinase-a-case-report
#15
Jie Zeng, Rong-Quan He, Wei-Guang Mo, Zhi-Gang Peng, Jie Ma, Jin-Cai Zhong, Chao-Hua Mo, Mei-Jiao Qin, Xiao-Hua Hu
CONTEXT: Inflammatory myofibroblastic tumors are a rare type of soft-tissue tumor. Inflammatory myofibroblastic tumors are characterized by rearrangements involving the anaplastic lymphoma kinase gene locus on 2p23. CASE REPORT: We report the case of a 67-year-old Chinese male who presented with dysuria and fever. Magnetic resonance imaging showed an irregular prostatic mass with an isointense signal and obscure boundary. Histopathological evaluation showed that the mass consisted mainly of spindle-shaped cells...
June 4, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29896398/cytological-characteristics-of-meningeal-solitary-fibrous-tumor-metastatic-to-the-lung-a-case-report-with-immunocytochemical-analysis
#16
Kaori Sandoh, Mitsuaki Ishida, Kimiaki Okano, Yusuke Ebisu, Kento Fukumoto, Tomohito Saito, Tomohiro Murakawa, Tokiko Nakai, Kinta Hatakeyama, Chiho Ohbayashi, Koji Tsuta
Solitary fibrous tumor (SFT) is a relatively uncommon mesenchymal tumor, and its occurrence in the meninges is rare. We herein report what is, to the best of our knowledge, the first cytological case of meningeal SFT metastatic to the lung with immunocytochemical analysis for signal transducer and activator of transcription 6 (STAT6), and compare the cytological characteristics to those of pleuropulmonary SFT. A 58-year-old Japanese male patient was found to have multiple nodules in the bilateral lungs after surgery for meningeal SFT...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29886588/-gastrointestinal-leiomyoma-with-interstitial-cells-of-cajal-mimicker-of-gastrointestinal-stromal-tumor
#17
G M Hu, Y K Feng, Q Y Liu, H P Chen, W J Fu, M Zhang, J Chang, B Gu, H F Wu, J L Ren
Objective: To study clinical and pathologic characteristics of leiomyomas of the gastrointestinal tract, and to investigate the distribution characteristics of interstitial cells of Cajal ( ICCs ) in gastrointestinal leiomyomas. Methods: One hundred and forty-seven cases of leiomyomas of gastrointestinal tract were collected at the Second Affiliated Hospital of Zhengzhou University from June 2012 to June 2017. Clinical and pathologic findings were analyzed, combined with immunohistochemistry, Alcian blue-osafranin staining and molecular study...
June 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29881993/primary-intracranial-spindle-cell-sarcoma-with-rhabdomyosarcoma-like-features-share-a-highly-distinct-methylation-profile-and-dicer1-mutations
#18
Christian Koelsche, Martin Mynarek, Daniel Schrimpf, Luca Bertero, Jonathan Serrano, Felix Sahm, David E Reuss, Yanghao Hou, Daniel Baumhoer, Christian Vokuhl, Uta Flucke, Iver Petersen, Wolfgang Brück, Stefan Rutkowski, Sandro Casavilca Zambrano, Juan Luis Garcia Leon, Rosdali Yesenia Diaz Coronado, Manfred Gessler, Oscar M Tirado, Jaume Mora, Javier Alonso, Xavier Garcia Del Muro, Manel Esteller, Dominik Sturm, Jonas Ecker, Till Milde, Stefan M Pfister, Andrey Korshunov, Matija Snuderl, Gunhild Mechtersheimer, Ulrich Schüller, David T W Jones, Andreas von Deimling
Patients with DICER1 predisposition syndrome have an increased risk to develop pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, and several other rare tumor entities. In this study, we identified 22 primary intracranial sarcomas, including 18 in pediatric patients, with a distinct methylation signature detected by array-based DNA-methylation profiling. In addition, two uterine rhabdomyosarcomas sharing identical features were identified. Gene panel sequencing of the 22 intracranial sarcomas revealed the almost unifying feature of DICER1 hotspot mutations (21/22; 95%) and a high frequency of co-occurring TP53 mutations (12/22; 55%)...
June 7, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29881291/a-large-and-aggressive-fibromatosis-in-the-axilla-a-rare-case-report-and-review-of-the-literature
#19
Mingyue Duan, Hua Xing, Keren Wang, Chunbo Niu, Chengwei Jiang, Lijuan Zhang, Shereen Ezzat, Le Zhang
Aggressive fibromatosis (AF) is a rare benign tumor, which occurs in the deep part of bone and muscle fibrous tissue. Clinical and pathological features can be challenging for definitive diagnosis. Here, we report a rare case of a large AF in the axilla. Interestingly, 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography showed significant increase in standard uptake value. Surgical resection yielded a spindle cell tumor likely of fibromatosis origin which was positive for β-catenin expression...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29879067/a-rare-subtype-of-meningioma-case-series-of-anaplastic-meningioma-and-review-of-the-literature
#20
Hongyi Cao, Biying Jiang, Yang Zhao, Chuifeng Fan
RATIONALE: Anaplastic meningioma, a rare subtype of meningioma, has malignant morphological characteristics and a World Health Organization (WHO) grade of III. PATIENT CONCERNS: In this report, we present findings from 6 cases of anaplastic meningioma. DIAGNOSES: Pathological examination of the tumors, including hematoxylin and eosin staining and immunohistochemical staining, was performed. Of the six cases of anaplastic meningioma, two were recurrent tumors from original seminoma with a WHO grade of I...
June 2018: Medicine (Baltimore)
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