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https://www.readbyqxmd.com/read/29676322/corneal-fibroma-an-uncommon-stromal-tumor
#1
Akshay Gopinathan Nair, Hemal Kenia, Indumati Gopinathan, Siddharth V Mehta, Vinod C Mehta
A 56-year-old male patient presented with a slow-growing, elevated, smooth, white corneal mass. The mass was excised by performing an alcohol-assisted keratoepitheliectomy and sent for histopathological examination. Subepithelially, closely packed spindle cells in "feather-stitched" or storiform pattern were seen. Immunohistochemically, the cells stained negatively for CD-34 and S-100 and focal positivity was seen for vimentin. Based on the morphology and immunochemical staining, a diagnosis of corneal fibroma was made...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29673102/cytodiagnosis-of-inflammatory-myofibroblastic-tumor-a-report-of-three-cases-in-infants
#2
Moupali Ghosh, Nelofar Islam, Hinglaj Saha, Madhumita Mukhopadhyay, Chhanda Datta, Koushik Saha, Uttara Chatterjee
Inflammatory myofibroblastic tumor is a tumor of intermediate grade with a low rate of metastasis. The tumor often mimics malignancy. There is sparse literature available describing the cytological findings of this rare condition. It often presents in infancy and childhood as an intra-abdominal mass. Here, we describe the cytological findings of three cases of inflammatory myofibroblastic tumor in infants aged 10 months, 4 months, and 15 months, respectively. While the first two cases are fine needle aspiration cytology (FNAC) smears, the third case is that of an intraoperative imprint cytology...
April 19, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29672549/tumor-development-in-japanese-patients-with-lynch-syndrome
#3
Chiaki Saita, Tatsuro Yamaguchi, Shin-Ichiro Horiguchi, Rin Yamada, Misato Takao, Takeru Iijima, Rika Wakaume, Tomoyuki Aruga, Taku Tabata, Koichi Koizumi
BACKGROUND: Lynch syndrome (LS) patients have a high risk of developing various tumors. This study aimed to clarify the characteristics of tumors developing in LS patients. METHODS: This is a retrospective review of 55 LS patients treated at Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital. RESULTS: The median age at the diagnosis of the first malignant tumor and first LS-related tumor was 44 (range, 19-65) and 44 (range, 24-66) years, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29670724/oral-bilateral-collagenous-fibroma-a-previously-unreported-case-and-literature-review
#4
Ana-Carolina Vasconcelos, Ana-Paula Gomes, Sandra Tarquinio, Eduardo Abduch-Rodrigues, Ricardo Mesquita, Karine Silva
Collagenous fibroma, also known as desmoplastic fibroblastoma, is a rare benign slow growing tumor particularly uncommon in the oral cavity. The aim of this study was to analyze the clinical and histopathological features of an oral collagenous fibroma as well as to compare this data with those reported in an English-literature review. The thirteenth case of collagenous fibroma in the oral cavity and the first to present clinically as a bilateral mass was described. A 48-years-old female patient was referred to a School of Dentistry, complaining about an asymptomatic swelling on the hard palate, lasting around ten years...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29660567/summary-of-expression-of-sparc-protein-in-cutaneous-vascular-neoplasms-and-mimickers
#5
Shakuntala H Mauzo, Denái R Milton, Victor G Prieto, Carlos A Torres-Cabala, Wei-Lien Wang, Nitin Chakravarti, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Robert E Brown, Phyu P Aung
BACKGROUND: Serum protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein, which regulates cell proliferation and facilitates intracellular transport of albumin bound particles including chemotherapeutic agents such as Nab-paclitaxel/ABI-007. Therefore the presence of SPARC may achieve higher intra-tumoral drug concentration with lower dosage and thus reduce systemic side-effects. Several trials of ABI-007, in melanoma, show promising clinical activity. DESIGN: Fifty-four cases of dermal based neoplasms were retrieved including 24 angiosarcomas (AS), 10 hemangiomas, 9 nodular melanomas, 4 Kaposi sarcomas (KS), 3 leiomyosarcomas (LMS), 3 atypical fibroxanthomas (AFX) and 1 spindle cell squamous cell carcinoma (SSCC)...
March 15, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29660566/extrapleural-solitary-fibrous-tumor-a-distinct-entity-from-pleural-solitary-fibrous-tumor-an-update-on-clinical-molecular-and-diagnostic-features
#6
REVIEW
Andrea Ronchi, Immacolata Cozzolino, Federica Zito Marino, Marina Accardo, Marco Montella, Iacopo Panarese, Giuseppe Roccuzzo, Giorgio Toni, Renato Franco, Annarosaria De Chiara
Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that was originally described to be localized in the pleura, but thereafter, this has been reported in several anatomic sites. Although the etiology of the neoplasm remains largely unknown, the pathogenesis seems to be related to an NAB2-STAT6 fusion gene due to paracentric inversion on chromosome 12q13. The diagnosis of extrapleural SFT is challenging, owing to its rarity, and requires an integrated approach that includes specific clinical, histological, immunohistochemical, and even molecular findings...
April 9, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29658593/laterally-spreading-features-of-gastrointestinal-stromal-tumors-a-clinicopathological-study
#7
Susumu Matsukuma, Michinori Murayama, Yoshitaka Utsumi, Koji Sumi, Kosuke Miyai, Hiroaki Takeo
To elucidate the histopathological features of laterally spreading gastrointestinal stromal tumors (GISTs), we retrospectively examined 52 GISTs grossly completely resected from 50 patients. Laterally spreading features were identified in 7 GISTs (13%), and were localized within non‑thickened regions of the muscularis propria adjacent to the main GISTs, ranging in length from 0.12 to 0.7 cm (mean, 0.3 cm). The laterally spreading features involved the muscular surgical margins in 2 cases. The morphologies of the laterally spreading cells resembled those of tumor cells in 4 cases, but were comprised of more slender spindle cells with smaller nuclei compared with those in the respective main GISTs...
April 10, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29650917/-a-case-of-primary-spinddle-cell-carcinoma-of-the-breast
#8
Hiroshi Kawai, Chihiro Yoshikawa, Kento Kawasaki, Norichika Iga, Ryosuke Yoshida, Naohisa Waki, Futoshi Uno, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita, Shinichiro Miyoshi
A 76-year-old female underwent breast-conserving surgery of the right breast and sentinel lymph node biopsy for primary breast cancer. Three years later, mammography and ultrasonography showed a small nodule in the right breast. There was nothing abnormal in the left breast. Three months later, she complained of a huge and rapid growing mass in the left breast. Malignant cells were obtained on fine needle aspiration biopsy in the right breast tumor. But it was not possible to diagnose whether the left breast tumor was benign or malignant on fine needle aspiration biopsy and needle biopsy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650847/-a-case-of-adult-undifferentiated-sarcoma-of-the-liver-with-intraatrial-metastasis
#9
Koji Minami, Masahiko Sakoda, Satoshi Iino, Kiyokazu Hiwatashi, Kosei Maemura, Yuko Mataki, Hiroshi Kurahara, Yota Kawasaki, Yusuke Tsuruda, Tetsuro Setoyama, Hiroshi Okumura, Shigeho Maenohara, Shoji Natsugoe
A 24-year-old woman was admitted to the hospital for abdominal pain. Abdominal contrast-enhanced computed tomography( CT)revealed a cystic mass measuring 11×8 cm in the left lobe of the liver with extravasation. Vascular embolization was performed, but extravasation remained on CT images. She was then transferred to our hospital. We performed an emergency extended left hepatectomy. Histopathological examination revealed solid proliferation of spindle-shaped cells. Immunohistochemical staining showed that the tumor cells were positive for vimentin and negative for AE1/AE3...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649038/the-effect-and-mechanism-of-millepachine-disrupted-spindle-assembly-in-tumor-cells
#10
Wenshuang Wu, Feng Liu, Anping Su, Yanping Gong, Wanjun Zhao, Yang Liu, Haoyu Ye, Jingqiang Zhu
Millepachine (MIL) is a bioactive natural product that shows great potential for cancer treatment. Previous studies showed that MIL was a novel cancer drug candidate with a special structure. To provide reference for the research and development of MIL, we further investigated the mechanism of MIL inducing G2/M arrest and found MIL disrupted spindle assembly in tumor cells. In this study, we investigated the disrupting spindle assembly effects of MIL with a focus on its potential mechanism of action. First, we indicated that MIL did not inhibit microtubule polymerization from the results of in-vivo microtubule nucleation assay and microtubule polymerization in-vitro assay but delayed this process by inhibiting the production of ATP in tumor cells...
June 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29645059/diagnosis-of-thymic-epithelial-tumor-subtypes-by-a-quantitative-proteomic-approach
#11
Ting Zhao, Jie Wu, Xiaohui Liu, Lei Zhang, Gang Chen, Haojie Lu
The histological typing of thymic epithelial tumours (TETs) still remains a challenge for surgical pathologists, especially when encountering borderline cases mainly focused on spindle cell types (including type A, atypical type A (aA), AB, and B3). A systematic proteomics analysis of TETs was performed using isobaric tags for relative and absolute quantification (iTRAQ) labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS). In total, 6479 and 6305 proteins were identified and quantified, respectively...
April 12, 2018: Analyst
https://www.readbyqxmd.com/read/29643676/discordant-primary-resistance-to-imatinib-mesylate-in-the-same-individual-and-splenic-involvement-in-recurring-gastric-gastrointestinal-stromal-tumors-assessment-by-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#12
Preeti Fargose, Sandip Basu
Discordant primary resistance and response of the metastatic lesions in the same individual coupled with splenic involvement in gastrointestinal stromal tumors (GISTs) are relatively uncommon. We herein report such a case of recurring GIST of the stomach that presented with the involvement of spleen with 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) imaging documentation. Ultrasonography-guided fine needle aspiration cytology from the splenic and paravesical lesions demonstrated metastatic spindle cell tumor consistent with diagnosis of metastasis from GIST of the stomach...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29642647/erbb1-and-erbb2-positive-medullary-thyroid-carcinoma-a-case-report
#13
Michele Minuto, Emanuela Varaldo, Gianluca Marcocci, Amleto de Santanna, Ermanno Ciccone, Katia Cortese
Medullary thyroid carcinomas (MTCs) are rare thyroid tumors occurring in both sporadic and hereditary forms, whose pathogenesis is related to RET proto-oncogene alterations. MTCs originate from parafollicular cells, which produce calcitonin that represents the biochemical activity of MTC. Total thyroidectomy is the main treatment for MTC and often cures patients with confined diseases. In the presence of metastasis, the therapeutic approach depends on the rate of disease progression. We report a case of a 54-year-old female with a single, incidentally discovered, thyroid nodule of 1 cm, classified as suspicious MTC after a stimulation test with intravenous (iv) calcium...
April 10, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29629646/fibroblastic-osteosarcoma-with-epithelioid-and-squamous-differentiation-in-a-dog
#14
Tiffany L Jenkins, Dalen Agnew, Daniel R Rissi
A fibroblastic osteosarcoma with epithelioid and squamous differentiation in the distal femur of a 9-y-old spayed female Greyhound dog is described. Grossly, the tumor consisted of a pale-white, firm-to-hard mass that replaced the medullary and cortical areas of the distal end of the right femur. Histologically, the mass was composed predominantly of spindle cells admixed with areas of mineralized and non-mineralized osteoid matrix that were surrounded by stellate osteoblasts and scattered multinucleate giant cells, consistent with the diagnosis of a fibroblastic osteosarcoma...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29628731/myofibroblastoma-of-the-breast-a-rare-cause-of-breast-lump-in-a-postmenopausal-woman
#15
Yasmeen Khatib, Vinita Pandey, Archana L Khade, Rahul Pandey
A breast mass in a postmenopausal age woman is treated with a high index of clinical suspicion for malignancy. Myofibroblastoma (MFB) of the breast is a very rare benign stromal tumor, predominantly occurring in menopausal women and older men. Owing to its rarity, nonspecific radiology, cytomorphology, and many variants, it can be confused with other malignant and benign breast lesions and hence can be a source of diagnostic pitfall. We present a case of an MFB of the breast in a 55-year-old female, which was detected on a routine screening mammography...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29626599/expanding-the-histomorphologic-spectrum-of-tfe3-rearranged-pecomas
#16
Nolan Maloney, Krinio Giannikou, Joel Lefferts, Julia A Bridge, Konstantinos Linos
Perivascular epithelioid tumors (PEComas) are a family of mesenchymal neoplasms that have smooth muscle and melanocytic differentiation. They can be sporadic or associated with Tuberous Sclerosis Complex and commonly present in the kidney as angiomyolipoma or in the lung as pulmonary clear cell sugar tumors or lymphangioleiomyomatosis. However, they can present at any visceral or soft tissue site. They usually have a benign clinical course, but rarely can behave in a malignant fashion. Most PEComas demonstrate abnormalities of TSC2, but a recently described subset harbor TFE3 rearrangements that appear to be mutually exclusive of TSC2 alterations...
April 4, 2018: Human Pathology
https://www.readbyqxmd.com/read/29624700/sarcomatoid-pilomatrix-carcinoma
#17
Angel Fernandez-Flores, David S Cassarino
Pilomatrical (pilomatrix) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only four cases previously published. We present an additional case on the hand of a 78 year-old man which appeared as a 6 mm hyperkeratotic ─focally ulcerated─ plaque. A shave biopsy demonstrated a dermal infiltrative neoplasm, composed of markedly atypical-appearing basaloid cells with focal necrotic/ghost cells, as well as an intimately associated population of atypical oval to spindle-shaped cells...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29620583/inflammatory-myofibroblastic-tumor-arising-in-the-cul-de-sac-mimicking-ectopic-decidua
#18
Ioannis Ioannidis, Jui-Han Huang
Extra-ovarian neoplasms incidentally discovered during cesarean section are very rare. Here we report a case of inflammatory myofibroblastic tumor found during cesarean section of a 30-year-old, full-term woman, forming a mass in her cul-de-sac. Histology revealed an extensively decidualized spindle cell process, positive for anaplastic large cell lymphoma kinase (ALK) through immunohistochemistry and fluorescent in situ hybridization (FISH). To the best of our knowledge, this is the first presentation of inflammatory myofibroblastic tumor in this location without concurrent intrauterine component, that additionally demonstrates this degree of decidualization, mimicking ectopic decidua...
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29620292/nik%C3%A2-and-ikk%C3%AE-%C3%A2-binding-protein-contributes-to-gastric-cancer-chemoresistance-by-promoting-epithelial%C3%A2-mesenchymal-transition-through-the-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway
#19
Zhen-Hua Fu, Shi-Quan Liu, Meng-Bin Qin, Jie-An Huang, Chun-Yan Xu, Wen-Hong Wu, Li-Ye Zhu, Nan Qin, Ming-Yu Lai
Systematic chemotherapy is indispensable for gastric cancer patients with advanced stage disease, but the occurrence of chemoresistance drastically limits treatment effectiveness. There is a tremendous need for identifying the underlying mechanism of chemoresistance. NIK‑ and IKKβ‑binding protein (NIBP) (also known as TRAPPC9, trafficking protein particle complex 9) is a regulator of the cytokine‑induced NF‑κB signaling pathway which has been proven to play pivotal roles in the progression of various malignancies...
March 30, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29616170/spindle-cell-lipoma-of-the-thumb
#20
Shogo Ebisudani, Ikuko Osugi, Kiichi Inagawa, Yoshinori Suzuki, Tomomi Kimura
We report the case of a 34-year-old man who presented with a 4-year history of a soft tissue on the palmar aspect of the thumb. Magnetic resonance imaging demonstrated the presence of a mass with heterogeneous high intensities on T1-weighted images and high intensities on T2-weighted images. We performed excisional biopsy. Histologically, the tumor was composed of mature adipocytes and spindle cells in a collagen background. Immunohistochemically, the tumor cells showed strong expression of CD34. Therefore, we diagnosed it as spindle cell lipoma...
February 2018: Plastic and Reconstructive Surgery. Global Open
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