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https://www.readbyqxmd.com/read/28730250/metastatic-high-grade-myxofibrosarcoma-review-of-a-clinical-case
#1
Tiberiu Paul Neagu, Ruxandra Diana Sinescu, Valentin Enache, Sanda Claudia Achim, Mirela Ţigliş, Liliana Elena Mirea
We present the particular clinical and histological features of a metastatic high-grade myxofibrosarcoma (MFS) of the left buttock in a 77-year-old male patient. The tumor was biopsied and surgically removed in order to increase the patient's comfort, due to its increased size and aggressive clinical behavior. Computed tomography (CT) revealed metastases in the pleura and mediastinal lymph nodes, so limb-sparing tumor excision followed by palliative care was the best practice for the patient until the fatal outcome...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28719466/dedifferentiated-liposarcoma-with-epithelioid-epithelial-features
#2
Naohiro Makise, Akihiko Yoshida, Motokiyo Komiyama, Fumihiko Nakatani, Kan Yonemori, Akira Kawai, Masashi Fukayama, Nobuyoshi Hiraoka
Dedifferentiated liposarcoma (DDLPS) demonstrates a variety of growth patterns, and their histologic resemblance to other spindle cell mesenchymal tumors has been widely recognized. However, epithelioid morphology in DDLPS has only rarely been documented. Here, we report 6 cases of DDLPS with striking epithelioid/epithelial features. The patients were 5 men and 1 woman with a median age of 61 years. All tumors were located in the internal trunk. During follow-up of 1 to 41 months, local recurrence, distant metastases, and tumor-related death occurred in 4, 2, and 4 patients, respectively...
July 20, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28719462/spindle-cell-lipomas-in-women-a-report-of-53-cases
#3
Jennifer S Ko, Brianne Daniels, Patrick O Emanuel, Paul Elson, Vadim Khachaturov, Jesse K McKenney, John R Goldblum, Steven D Billings
Spindle cell lipomas (SCL) are typically tumors of the upper back/neck (shawl region) of men (80% to 90%). In general, there is a frequent tendency to restrict the diagnosis to this specific clinical scenario and a hesitancy to diagnose SCL in women. We hypothesized that SCL in women have a more varied presentation. A total of 395 SCL were diagnosed at our institution over the last 11 years. The diagnosis of SCL in women was confirmed by re-review. Immunohistochemical stains for CD34, desmin, estrogen receptor, and p16 were performed...
July 17, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28718377/downregulation-of-tyrosine-threonine-kinase-inhibits-tumor-growth-via-g2-m-arrest-in-human-endometrioid-endometrial-adenocarcinoma
#4
Jiamiao Zhang, Yan Jiang, Yu Zhao, Wanxue Wang, Yiran Xie, Huating Wang, Yihua Yang
Endometrial cancer is the most common gynecologic malignancy, about 80% of which is endometrial endometrioid carcinoma. Dysregulation of spindle assembly checkpoint plays a vital role in endometrial endometrioid carcinoma tumorigenesis and progression. The purpose of this study was to explore how tyrosine threonine kinase, a spindle assembly checkpoint-related protein, promotes the endometrial endometrioid carcinoma progression. We found that both messenger RNA and protein levels of tyrosine threonine kinase in endometrial endometrioid carcinoma tissues are higher than those in normal endometrial tissues, and its expression is associated with tumor stages...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28705706/inflammatory-myofibroblastic-tumors-of-the-lung-carrying-a-chimeric-a2m-alk-gene-report-of-two-infantile-cases-and-review-of-the-differential-diagnosis-of-infantile-pulmonary-lesions
#5
Mio Tanaka, Kenichi Kohashi, Kei Kushitani, Misa Yoshida, Sho Kurihara, Masumi Kawashima, Yuka Ueda, Ryota Souzaki, Yoshiaki Kinoshita, Yoshinao Oda, Yukio Takeshima, Eiso Hiyama, Tomoaki Taguchi, Yukichi Tanaka
We report two infantile cases of pulmonary tumor carrying a chimeric A2M-ALK gene. A2M-ALK is a newly identified anaplastic lymphoma kinase (ALK)-related chimeric gene from a tumor diagnosed as fetal lung interstitial tumor (FLIT). FLIT is a recently recognized infantile pulmonary lesion defined as a mass-like lesion that morphologically resembles the fetal lung. Grossly, FLIT characteristically appears as a well-circumscribed spongy mass, whereas the tumors in these patients were solid and firm. Histologically, the tumors showed intrapulmonary lesions composed of densely proliferating polygonal or spindle-shaped mesenchymal cells with diffuse and dense infiltrations of inflammatory cells, forming microcystic or micropapillary structures lined by TTF1-positive pneumocytes, favoring IMT rather than FLIT...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28704208/hgnet-bcor-tumors-of-the-cerebellum-clinicopathologic-and-molecular-characterization-of-3-cases
#6
Romain Appay, Nicolas Macagno, Laetitia Padovani, Andrey Korshunov, Marcel Kool, Nicolas André, Didier Scavarda, Torsten Pietsch, Dominique Figarella-Branger
The central nervous system (CNS) high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR) is a recently described molecular entity. We report 3 new CNS HGNET-BCOR cases sharing common clinical presentation and pathologic features. The 3 cases concerned children aged 3 to 7 years who presented with a voluminous mass of the cerebellum. Pathologic features included proliferation of uniform spindle to ovoid cells with fine chromatin associated with a rich arborizing capillary network. Methylation profiling classified these cases as CNS HGNET-BCOR tumors...
July 12, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28704194/sarcomatoid-squamous-cell-carcinoma-of-the-penis-a-report-of-two-cases
#7
Svitlana Y Bachurska, Petar A Antonov, Dmitriy G Staykov, Ivan Y Dechev
BACKGROUND: Sarcomatoid (spindle cell) squamous cell carcinoma is a rare, highgrade, aggressive tumor consisting of the squamous cell carcinoma admixed with the malignant spindle cell (sarcomatoid) elements. These tumors are relatively uncommon in the genitourinary system and particularly in the penis. MATERIALS AND METHODS: Two sarcomatoid squamous cell carcinomas of the penis were diagnosed in our hospital between 2012 and 2015. Clinical histories, pathology reports, hematoxylin and eosin-stained and immunohistochemical slides were reviewed...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28701831/intestinal-gist-masquerading-as-an-ovarian-mass-diagnosed-on-fnac
#8
Surbhi Goyal, Vinod K Arora, Mohit K Joshi, Navjeevan Singh, Gita Radhakrishnan
The preoperative diagnosis of metastatic intestinal gastrointestinal stromal tumors (GIST) on cytology can be quite difficult at times. The present case characterizes the cytomorphological and immunocytochemical features of GIST, emphasizing the utility of fine-needle aspiration cytology (FNAC) in the evaluation of spindle cell tumors of gastrointestinal tract. An accurate and early diagnosis of GIST affects the treatment, primarily allowing the use of tyrosine kinase inhibitors in unresectable or metastatic cases...
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28690098/m%C3%A3-llerian-adenosarcoma-of-the-urinary-bladder-clinicopathologic-and-immunohistochemical-features-with-novel-genetic-aberrations
#9
Joseph Sanfrancesco, Sean R Williamson, Jennifer B Kum, Shaobo Zhang, Mingsheng Wang, Antonio Lopez-Beltran, Rodolfo Montironi, Thomas A Gardner, Liang Cheng
BACKGROUND: Müllerian adenosarcoma is a biphasic neoplasm most commonly occurring in the uterus and less frequently of the ovary. It has been rarely described to occur in other sites such as peritoneum and liver. PATIENTS AND METHODS: In this study, we report the clinicopathologic, immunohistochemical and molecular features of a primary Müllerian adenosarcoma of the urinary bladder in a 62-year-old woman. To our knowledge, this is the first report of detailed pathologic characterization of Müllerian adenosarcoma primary to the urinary bladder in the literature...
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28687087/a-rare-case-of-malignant-solitary-fibrous-tumor-in-prostate-with-review-of-the-literature
#10
Andrea Ronchi, Elvira La Mantia, Vincenzo Gigantino, Sisto Perdonà, Marco De Sio, Gaetano Facchini, Renato Franco, Annarosaria De Chiara
BACKGROUND: Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described in the prostate. The present case is characterized by some peculiarities if compared with previously reported cases of prostatic malignant solitary fibrous tumor. Firstly, it does not show a homogeneous morphology: part of the neoplasm (about 50%) showed the features of a conventional solitary fibrous tumor, while the remaining part showed the features of a malignant solitary fibrous tumor...
July 7, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28686500/guidelines-for-pathologic-diagnosis-of-malignant-mesothelioma-2017-update-of-the-consensus-statement-from-the-international-mesothelioma-interest-group
#11
Aliya Noor Husain, Thomas V Colby, Nelson G Ordóñez, Timothy Craig Allen, Richard Luther Attanoos, Mary Beth Beasley, Kelly Jo Butnor, Lucian R Chirieac, Andrew M Churg, Sanja Dacic, Françoise Galateau-Sallé, Allen Gibbs, Allen M Gown, Thomas Krausz, Leslie Anne Litzky, Alberto Marchevsky, Andrew G Nicholson, Victor Louis Roggli, Anupama K Sharma, William D Travis, Ann E Walts, Mark R Wick
CONTEXT: - Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: - To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: - Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the field contributed to this update. Reference material included up-to-date, peer-reviewed publications and textbooks. CONCLUSIONS: - There was discussion and consensus opinion regarding guidelines for (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) recognition of the key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas, and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid MM, (7) use of molecular markers in the diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM...
July 7, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28685135/duodenal-gangliocytic-paraganglioma-with-lymph-node-metastases-a-case-report-and-comparative-review-of-31-cases
#12
Sahara J Cathcart, Aaron R Sasson, Jessica A Kozel, Jennifer M Oliveto, Quan P Ly
Gangliocytic paraganglioma (GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindle-like/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy...
June 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28681243/synergistic-inhibition-of-glioma-cell-proliferation-by-withaferin-a-and-tumor-treating-fields
#13
Edwin Chang, Christoph Pohling, Nooshin Beygui, Chirag B Patel, Jarrett Rosenberg, Dong Ho Ha, Sanjiv S Gambhir
Glioblastoma (GBM) is the most aggressive and lethal form of brain cancer. Standard therapies are non-specific and often of limited effectiveness; thus, efforts are underway to uncover novel, unorthodox therapies against GBM. In previous studies, we investigated Withaferin A, a steroidal lactone from Ayurvedic medicine that inhibits proliferation in cancers including GBM. Another novel approach, tumor treating fields (TTFields), is thought to disrupt mitotic spindle formation and stymie proliferation of actively dividing cells...
July 5, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28676915/characterization-of-the-new-human-pleomorphic-undifferentiated-sarcoma-tp53-null-cell-line-mfh-val2
#14
Rosario Gil-Benso, Javier Megías, Teresa San-Miguel, Sandra Pinto, Robert C Callaghan, Concha López-Ginés, Miguel Cerdá-Nicolás
Pleomorphic undifferentiated sarcoma (PUS), also called malignant fibrous histiocytoma, is a soft tissue sarcoma which occurs predominantly in the extremities. Its origin is a poorly defined mesenchymal cell, which derives to histiocytic and fibroblastic cells. The patient, a 58 year-old man, presented a lesion located in the forearm composed by spindle cells and multinucleated giant cells, which expressed vimentin and adopted a histological pattern formed by irregular-swirling fascicles. Cells were cultured in vitro and a new cell line was established...
July 4, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28674580/-mucinous-tubular-and-spindle-cell-carcinoma-a-rare-renal-tumor
#15
Oussama Ziouani, Abdelilah Elalaoui, Hicham Elbote, Salwa Belhabib, Hachem El Sayegh, Ali Iken, Lounis Benslimane, Fouad Zouaidia, Yassine Nouini
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28673316/somatic-loss-of-estrogen-receptor-beta-and-p53-synergize-to-induce-breast-tumorigenesis
#16
Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson, Christoforos Thomas
BACKGROUND: Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive breast tumors. However, proof of an association between loss of ERβ and breast carcinogenesis is still missing. METHODS: To study the role of ERβ in breast oncogenesis, we generated mouse conditional mutants with specific inactivation of ERβ and p53 in the mammary gland epithelium...
July 3, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28671973/pd-l1-expression-in-pleomorphic-spindle-cell-and-giant-cell-carcinoma-of-the-lung-is-related-to-ttf-1-p40-expression-and-might-indicate-a-worse-prognosis
#17
Violaine Yvorel, Arnaud Patoir, François Casteillo, Claire Tissot, Pierre Fournel, Marie-Laure Stachowicz, Georgia Karpathiou, Olivier Tiffet, Michel Péoc'h, Fabien Forest
Lung sarcomatoid carcinoma of the lung is a rare tumor with a poor prognosis. More than 90% of them are pleomorphic, spindle cell and giant cell carcinoma (PSCGCC). This rare subtype of lung cancer is thought to be more resistant to chemotherapy, and a small subset of them seems to exhibit targetable mutations. Immunotherapy against PD1/PDL-1 is a new emerging treatment, and might be of interest in PSGSCC because they frequently express PD-L1. The aim of our work is to evaluate PD1 and PDL-1 expression in a surgical series of lung PSCGCC and their relationship with morphological and immunohistochemical parameters and prognosis...
2017: PloS One
https://www.readbyqxmd.com/read/28670068/spindle-cell-sarcoma-involving-the-major-pulmonary-arteries
#18
Mohamed Teleb, Cristina Chacon Olivas, Obiajulu Kanu, Luis Duran Ramos, Kyari Sumayin Ngamdu, Aymen Albaghdadi, Wael El Mallah
Primary pulmonary vasculature tumors are exceptionally rare, with only a few reported cases. Signs and symptoms of such neoplasms vary but include dyspnea, cough, and chest pain. This condition is associated with a high mortality rate and is easily misdiagnosed as a pulmonary artery embolism. We pre-sent a case of pulmonary artery sarcoma that demonstrates the value of cardiac magnetic resonance imaging for accurate diagnosis.
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28668473/multiple-recurrences-require-long-term-follow-up-in-patients-diagnosed-with-spindle-cell-oncocytoma-of-the-sella-turcica
#19
Branavan Manoranjan, Alex Koziarz, Michelle M Kameda-Smith, John P Provias
Spindle cell oncocytoma (SCO) of the sella turcica is characterized as a WHO grade I non-endocrine neoplasm of the sella turcica. Histologically, these tumors contain spindled and variably oncocytic cellular processes. Although SCOs lack immunoreactivity for neuroendocrine markers and pituitary hormones, they are clinically indistinguishable from non-functioning pituitary adenomas. In contrast to the initially described benign clinical course, several reports have subsequently illustrated cases with multiple recurrences with or without histological features of anaplasia in the form of nuclear pleomorphism, frequent mitoses, high Ki-67 index, and/or necrosis...
June 28, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28666505/cystic-pleural-synovial-sarcoma
#20
Atif Sharif, Tasleem Akhtar, Mumtaz Akhtar, Naeem Zia
Fewer than 40 cases of primary pleural synovial sarcoma have been reported so far with only 3 cases of cystic synovial sarcoma including cases originating from sites other than the pleura. Here, we present an exceedingly rare case of cystic synovial sarcoma originating from the mediastinal side of the visceral pleura in a 25-year man presenting with hemoptysis. On contrast-enhanced computed tomography (CT), cystic synovial sarcoma and cystic thymoma were difficult to be distinguished due to mediastinal location...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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