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https://www.readbyqxmd.com/read/29690773/therapeutic-inertia-in-antiplatelet-therapy-in-patients-with-a-cardiovascular-event-attended-in-an-emergency-department
#1
José Antonio García-Macías, Antonio Palazón-Bru, María Ángeles Carbonell-Torregrosa, Miguel Navarro-Juan, Vicente Francisco Gil-Guillén
OBJECTIVE: As very few studies have assessed therapeutic inertia (TI) in antiplatelet therapy in patients in secondary cardiovascular prevention, we designed a study in our hospital emergency department to quantify its magnitude and its associated factors. METHODS: This descriptive cross-sectional observational study involved a sample of 223 patients with a history of cardiovascular disease and recommendation for antiplatelet therapy who attended the emergency department in a Spanish region in 2016...
April 25, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29689241/pharmacologic-inhibition-of-s1p-attenuates-atf6-expression-causes-er-stress-and-contributes-to-apoptotic-cell-death
#2
Paul Lebeau, Jae Hyun Byun, Tamana Yousof, Richard C Austin
Mammalian cells express unique transcription factors embedded in the endoplasmic reticulum (ER) membrane, such as the sterol regulatory element-binding proteins (SREBPs), that promote de novo lipogenesis. Upon their release from the ER, the SREBPs require proteolytic activation in the Golgi by site-1-protease (S1P). As such, inhibition of S1P, using compounds such as PF-429242 (PF), reduces cholesterol synthesis and may represent a new strategy for the management of dyslipidemia. In addition to the SREBPs, the unfolded protein response (UPR) transducer, known as the activating transcription factor 6 (ATF6), is another ER membrane-bound transcription factor that requires S1P-mediated activation...
April 21, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29688015/a-peripherally-restricted-purine-antagonist-of-type-1-cannabinoid-cb1-receptor-blocks-alcoholic-steatosis-in-mice
#3
George Amato, Amruta Manke, Danni L Harris, Robert W Wiethe, Vineetha Vasukuttan, Rodney W Snyder, Timothy W Lefever, Ricardo Cortes, Yanan Zhang, Shaobin Wang, Scott P Runyon, Rangan Maitra
Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome and dyslipidemias. However, inhibition of CB1 receptors in the central nervous system can produce adverse effects including depression, anxiety and suicidal ideation. Efforts are now underway to produce peripherally restricted CB1 antagonists to circumvent CNS-associated undesirable effects. In this study, a series of analogs were explored in which the 4-aminopiperidine group of 2 was replaced with aryl and heteroaryl substituted piperazine groups both with and without a spacer...
April 24, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29685846/standardization-of-laboratory-lipid-profile-assessment-a-call-for-action-with-a-special-focus-on-the-2016-esc-eas-dyslipidemia-guidelines-executive-summary-a-consensus-endorsed-by-the-cardiovascular-risk-and-prevention-group-of-the-portuguese-internal-medicine
#4
Pedro Marques da Silva, João Sequeira Duarte, Pedro von Hafe, Victor Gil, Jorge Nunes de Oliveira, Germano de Sousa
Even with improvements in lifestyle interventions, better control of cardiovascular (CV) risk factors, and improvements in CV outcomes, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in Portugal and Europe. Atherogenic dyslipidemias, particularly hypercholesterolemia, have a crucial causal role in the development of atherosclerotic CVD. The clinical approach to a patient with dyslipidemia requires an accurate diagnosis, based on harmonized and standardized lipid and lipoprotein laboratory assessments...
April 20, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29685649/polygenic-link-between-blood-lipids-and-amyotrophic-lateral-sclerosis
#5
Xu Chen, Solmaz Yazdani, Fredrik Piehl, Patrik K E Magnusson, Fang Fang
Dyslipidemia is common among patients with amyotrophic lateral sclerosis (ALS). We aimed to test the association and causality between blood lipids and ALS, using polygenic analyses on the summary results of genome-wide association studies. Polygenic risk scores (PRSs) based on low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) risk alleles were significantly associated with a higher risk of ALS. Using single nucleotide polymorphisms (SNPs) specifically associated with LDL-C and TC as the instrumental variables, statistically significant causal effects of LDL-C and TC on ALS risk were identified in Mendelian randomization analysis...
March 27, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29685574/relation-between-lipid-profile-and-new-onset-atrial-fibrillation-in-patients-with-systemic-hypertension-from-the-swedish-primary-care-cardiovascular-database-spccd
#6
Georgios Mourtzinis, Thomas Kahan, Kristina Bengtsson Boström, Linus Schiöler, Louise Cedstrand Wallin, Per Hjerpe, Jan Hasselström, Karin Manhem
The relation between dyslipidemia and atrial fibrillation (AF) development is still controversial. To assess the impact of lipid profile on new-onset AF, we followed 51,020 primary-care hypertensive patients without AF at baseline. After a mean follow-up time of 3.5 years, AF occurred in 2,389 participants (4.7%). We evaluated the association between total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and new-onset AF. In a Poisson regression model fully adjusted for common risk factors of AF, we found that 1...
March 28, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29684459/treatment-of-dyslipidemia-in-common-liver-diseases
#7
Elizabeth K Speliotes, Maya Balakrishnan, Lawrence S Friedman, Kathleen E Corey
No abstract text is available yet for this article.
April 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29684222/liver-disease-in-a-residential-cohort-with-elevated-polychlorinated-biphenyl-exposures
#8
Heather B Clair, Christina M Pinkston, Shesh N Rai, Marian Pavuk, Nina D Dutton, Guy Brock, Russell A Prough, K Cameron Falkner, Craig J McClain, Matthew C Cave
Endocrine and metabolism disrupting chemicals (EDCs/MDCs) have been associated with environmental liver diseases including toxicant-associated steatohepatitis (TASH). TASH has previously been characterized by hepatocellular necrosis, disrupted intermediary metabolism, and liver inflammation. Polychlorinated biphenyls (PCBs) are environmental EDCs/MDCs associated with the genesis and progression of steatohepatitis in animal models and human liver injury in epidemiology studies. The cross-sectional Anniston Community Health Survey (ACHS) investigates ortho-substituted PCB exposures and health effects near a former PCB manufacturing complex...
April 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29683005/association-between-adherence-to-statins-illness-perception-treatment-satisfaction-and-quality-of-life-among-lebanese-patients
#9
Christine Haddad, Souheil Hallit, Mohammad Salhab, Aline Hajj, Antoine Sarkis, Eliane Nasser Ayoub, Hicham Jabbour, Lydia Rabbaa Khabbaz
OBJECTIVES: The main objective of this study was to evaluate treatment adherence to statin and health-related quality of life (QOL) in Lebanese patients with dyslipidemia. Secondary objectives were to examine associations between treatment adherence, QOL, treatment satisfaction, and illness perception. METHODS: This cross-sectional study, conducted in 20 community pharmacies from all districts of Lebanon between August 2016 and April 2017, enrolled 247 adult patients taking any statin...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29682734/the-role-of-pericardial-adipose-tissue-in-the-heart-of-obese-minipigs
#10
Chia-Yu Wang, Sin-Jin Li, Twin-Way Wu, Han-Jen Lin, Jyun-Wei Chen, Harry J Mersmann, Shih-Torng Ding, Ching-Yi Chen
BACKGROUND: Pericardial adipose tissue (PAT) volume is highly associated with the presence and severity of cardiometabolic diseases, but the underlying mechanism is unknown. We previously demonstrated that a high-fat diet (HFD) induced metabolic dysregulation, cardiac fibrosis, and accumulation of more PAT in minipigs. This study used our obese minipig model to investigate the characteristics of PAT and omental visceral fat (VAT) induced by a HFD, and the potential link between PAT and HFD-related myocardial fibrosis...
April 23, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29682733/upper-body-fat-predicts-metabolic-syndrome-similarly-in-men-and-women
#11
Scott M Grundy, Corbin Williams, Gloria L Vega
The metabolic syndrome is a constellation of risk factors including dyslipidemia, dysglycemia, hypertension, a pro-inflammatory state, and a prothrombotic state. All of these factors are accentuated by obesity. However, obesity can be defined by body mass index (BMI), percent body fat, or by body fat distribution. The latter consists of upper body fat (subcutaneous and visceral fat) and lower body fat (gluteofemoral fat). Waist circumference is a common surrogate marker for upper body fat. In this study, data from the National Health and Nutrition Examination Survey (NHANES) for the years 1999 - 2006 was examined for associations of metabolic risk factors with percent body fat, waist circumference, and BMI...
April 23, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29681050/relationship-between-erectile-dysfunction-diabetes-and-dyslipidemia-in-hypertensive-treated-men
#12
Jose J Zamorano-Leon, Antonio Segura, Vicente Lahera, Jose M Rodriguez-Pardo, Rafael Prieto, Ana Puigvert, Antonio J Lopez-Farre
PURPOSE: PRESIDEN study is a large study to analyze the erectile dysfunction (ED) incidence in Spanish population. The present study is a pilot sub-analysis from PRESIDEN to determine if ED or plasma testosterone (TST) level in controlled hypertensive patients may be associated with comorbidities and/or plasma nitrite+nitrate and antioxidant capacity. MATERIALS AND METHODS: Forty-four hypertensive individuals were aleatory selected from PRESIDEN study, matching by age (28 showing ED and 16 without ED)...
April 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29679801/metabolic-control-apoe-genotypes-and-dyslipidemia-in-children-adolescents-and-young-adults-with-type-1-diabetes
#13
Maddalena Macedoni, Tinka Hovnik, Emil Plesnik, Primoz Kotnik, Natasa Bratina, Tadej Battelino, Urh Groselj
BACKGROUND AND AIMS: Limited data is available on the factors influencing the lipid profiles and the prevalence of dyslipidemia in children, adolescents and young adults with type 1 diabetes. We aimed at assessing the influences of metabolic control and ApoE genotypes on lipid profiles and the prevalence of dyslipidemia in children, adolescents and young adults with type 1 diabetes. METHODS: Children, adolescents and young adults with type 1 diabetes from our nationwide cohort attending the annual check-up were prospectively included...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29678607/association-between-hypertension-and-metabolic-disorders-among-elderly-patients-in-north-jordan
#14
Nuha Alwardat, Laura Di Renzo, Renata Costa de Miranda, Sofian Alwardat, Paola Sinibaldi Salimei, Antonino De Lorenzo
BACKGROUND: Hypertension (HTN), dyslipidemia and hyperglycemia are major risk factors for cardiovascular disease, accounting for the highest morbidity and mortality among the elderly Jordanian population. This study aimed to evaluate serum lipid and glucose profiles of hypertensive patients and normotensive controls, and determine the risk factors for HTN among elderly population in Jordan. METHODS: A cross-sectional study was carried out among 200 participants, including 111 hypertensive patients and 89 normotensive controls from June to October 2017 in North Jordan...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678178/status-of-lipid-and-lipoprotein-in-female-breast-cancer-patients-at-initial-diagnosis-and-during-chemotherapy
#15
Xin Li, Zi-Li Liu, Yu-Tuan Wu, He Wu, Wei Dai, Bilal Arshad, Zhou Xu, Hao Li, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: The lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. METHODS: We conducted a retrospective cohort study of the status of the lipid and lipoprotein in 1054 primarily diagnosed breast cancer patients and 2483 normal controls with age stratification, from July 2015 to October 2016...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29677638/gestational-glucocorticoid-exposure-disrupts-glucose-homeostasis-that-is-accompanied-by-increased-endoglin-and-dpp-4-activity-instead-of-gsk-3-in-rats
#16
Olufunto O Badmus, Olugbenga S Michael, Saheed Rabiu, Lawrence A Olatunji
Gestational glucocorticoid (GC) treatment has been associated with cardiometabolic disorder (CMD) in offspring's in later life. Elevated dipeptidyl peptidase-4 (DPP-4) activity, endoglin and glycogen synthase kinase-3 (GSK-3) has also been implicated in the development of insulin resistance (IR) and/or vascular inflammation. We aimed to investigate the impact of GC exposure on glucose metabolism and the circulating levels of inflammatory biomarkers, DPP-4 activity and GSK-3 in pregnant rats. Pregnant Wistar rats received either vehicle or dexamethasone (DEX; 0...
April 13, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29677628/circulating-metabolomic-profile-can-predict-dyslipidemia-in-hiv-patients-undergoing-antiretroviral-therapy
#17
Esther Rodríguez-Gallego, Josep Gómez, Pere Domingo, Sara Ferrando-Martínez, Joaquim Peraire, Consuelo Viladés, Sergi Veloso, Miguel López-Dupla, Raúl Beltrán-Debón, Verónica Alba, Montserrat Vargas, Alfonso J Castellano, Manuel Leal, Yolanda María Pacheco, Ezequiel Ruiz-Mateos, Félix Gutiérrez, Francesc Vidal, Anna Rull
BACKGROUND AND AIMS: Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. METHODS: To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months...
April 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29676936/pediatric-metabolic-outcome-comparisons-based-on-a-spectrum-of-obesity-and-asthmatic-symptoms
#18
Ashley D Perdue, Lesley A Cottrell, Christa L Lilly, William A Gower, Brian A Ely, Brad Foringer, Melvin L Wright, William A Neal
RATIONALE: Asthma and obesity are two of the most prevalent public health issues for children in the U.S. Trajectories of both have roughly paralleled one another over the past several decades causing many to explore their connection to one another and to other associated health issues such as diabetes and dyslipidemia. Earlier models have commonly designated obesity as the central hub of these associations; however, more recent models have argued connections between pediatric asthma and other obesity-related metabolic conditions regardless of children's obesity risk...
April 20, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29676873/-bradykinin-and-cardiovascular-protection-role-of-perindopril-an-inhibitor-of-angiotensin-conversion-enzyme
#19
P Lancellotti, A Ancion, V D'Orio, O Gach, P Maréchal, J M Krzesinski
The endothelium plays a vital role as part of the cardiovascular continuum. Risk factors such as hypertension and dyslipidemia unbalance angiotensin II - bradykinin homeostasis, leading to endothelial dysfunction and changes in vascular structure that promote atherosclerosis and thrombosis. When dealing with risk factors, treatment should focus on the prevention and restoration of endothelial function. Not all cardiovascular drugs are able to reverse vascular and structural endothelial dysfunction. Increasing levels of bradykinin is an effect of the use of angiotensin-converting enzyme inhibitors (ACE-Is), and also a fundamental part of their mode of action...
April 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29675621/myocardial-function-in-primary-antiphospholipid-syndrome-using-speckle-tracking-echocardiography
#20
Gabriela Medina, Eduardo Gómez-Bañuelos, Erick Calderón-Aranda, María Pilar Cruz-Domínguez, Olga Vera-Lastra, Luis J Jara
Antiphospholipid syndrome (APS) patients have high cardiovascular risk. Speckle-tracking echocardiography (STE) detects myocardial function. To evaluate the myocardial function in primary APS (PAPS) patients using two-dimensional echocardiography (2-D) obtaining values of left ventricle global longitudinal strain (GLS) by STE. Patients with PAPS, > 16 years, both genders, without signs and symptoms of heart disease were recruited and matched with healthy controls by age and gender. Demographic, clinical data, and cardiovascular risk factors were recorded...
April 19, 2018: Clinical Rheumatology
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