keyword
MENU ▼
Read by QxMD icon Read
search

1. epidemiology

keyword
https://www.readbyqxmd.com/read/29169177/acute-kidney-injury-in-elderly-population-a-prospective-observational-study
#1
Cássia Gomes da Silveira Santos, Rafael Fernandes Romani, Ricardo Benvenutti, João Otávio Ribas Zahdi, Miguel Carlos Riella, Marcelo Mazza do Nascimento
BACKGROUND/AIMS: Acute kidney injury (AKI) has been reported as a recognized condition among the elderly population; however, its clinical epidemiology is still poorly evaluated. We propose to evaluate the epidemiological profile of AKI in hospitalized elderly patients and the variables associated with renal replacement therapy (RRT) dependency at discharge after an episode of AKI. METHODS: This prospective observational study enrolled 286 elderly patients (aged ≥60 years), who had a diagnosis of AKI and were admitted to a tertiary care hospital...
November 23, 2017: Nephron
https://www.readbyqxmd.com/read/29168991/an-assessment-of-the-cox-proportional-hazards-regression-model-for-epidemiologic-studies
#2
Suresh H Moolgavkar, Ellen T Chang, Heather N Watson, Edmund C Lau
The basic assumptions of the Cox proportional hazards regression model are rarely questioned. This study addresses whether hazard ratio, i.e., relative risk (RR), estimates using the Cox model are biased when these assumptions are violated. We investigated also the dependence of RR estimates on temporal exposure characteristics, and how inadequate control for a strong, time-dependent confounder affects RRs for a modest, correlated risk factor. In a realistic cohort of 500,000 adults constructed using the National Cancer Institute Smoking History Generator, we used the Cox model with increasing control of smoking to examine the impact on RRs for smoking and a correlated covariate X...
November 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29168548/guidelines-for-the-diagnosis-and-management-of-osteoporosis-in-poland-update-2017
#3
Roman Lorenc, Piotr Głuszko, Edward Franek, Mirosław Jabłoński, Maciej Jaworski, Ewa Kalinka-Warzocha, Elzbieta Karczmarewicz, Tomasz Kostka, Krystyna Księzopolska-Orłowska, Ewa Marcinowska-Suchowierska, Waldemar Misiorowski, Andrzej Więcek
In the rapidly ageing society in Poland, osteoporosis is a growing epidemiological problem, and osteoporosis-related fractures are a cause of chronic disability and considerable increase of death risk. It turns out that 80 to 90% of patients suffering from osteoporosis, including osteoporosis accompanied by fractures, do not receive adequate pharmacotherapy. In this paper, a Guideline Working Group of experts from the Multidisciplinary Osteoporosis Forum update the existing Polish guidelines concerning the diagnosis and management of osteoporosis (last revised in 2013), taking account of the latest literature, availability and reimbursement of drugs, and current health care organisation...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29168444/prevalence-and-molecular-identification-of-trichinella-species-isolated-from-wildlife-originating-from-limpopo-and-mpumalanga-provinces-of-south-africa
#4
S Mukaratirwa, L J La Grange, M P Malatji, B Reininghaus, J Lamb
Trichinella species are widely distributed on all continents with the exception of Antarctica, although the full spectrum of Trichinella species found in sub-Saharan African countries, and their hosts, has not been fully documented. This study was conducted to determine the prevalence of Trichinella in wildlife from the Greater Kruger National Park (GKNP) and adjacent areas located in the Limpopo and Mpumalanga provinces of South Africa, and to identify the species and/or genotypes of Trichinella larvae isolated from muscle tissues, using molecular techniques...
November 23, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/29168291/the-col5a3-and-mmp9-genes-interact-in-eczema-susceptibility
#5
Patricia Margaritte-Jeannin, Marie-Claude Babron, Catherine Laprise, Nolwenn Lavielle, Chloé Sarnowski, Myriam Brossard, Miriam Moffatt, Valérie Gagné-Ouellet, Adrien Etcheto, Mark Lathrop, Jocelyne Just, William O Cookson, Emmanuelle Bouzigon, Florence Demenais, Marie-Hélène Dizier
BACKGROUND: Genetic studies of eczema have identified many genes, which explain only 14% of the heritability. Missing heritability may be partly due to ignored Gene-Gene (G-G) interactions. OBJECTIVE: Our aim was to detect new interacting genes involved in eczema. METHODS: The search for G-G interaction in eczema was conducted using a two-step approach, which included as a first step, a biological selection of genes, which are involved either in the skin or epidermis development or in the collagen metabolism, and as a second-step, an interaction analysis of the selected genes...
November 23, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29168218/the-clinical-epidemiology-of-sickle-cell-anemia-in-africa
#6
Alex W Macharia, George Mochamah, Sophie Uyoga, Carolyne M Ndila, Gideon Nyutu, Johnstone Makale, Metrine Tendwa, Emily Nyatichi, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Norbert Peshu, Benjamin Tsofa, J Anthony G Scott, Kathryn Maitland, Thomas N Williams
Sickle cell anemia (SCA) is the commonest severe monogenic disorders of humans. The disease has been highly characterized in high-income countries but not in sub-Saharan Africa where SCA is most prevalent. We conducted a retrospective cohort study of all children 0-13 years admitted from within a defined study area to Kilifi County Hospital in Kenya over a five-year period. Children were genotyped for SCA retrospectively and incidence rates calculated with reference to population data. Overall, 576 of 18,873 (3...
November 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29168217/prevalence-management-and-prognosis-of-bladder-cancer-in-patients-with-neurogenic-bladder-a-systematic-review
#7
Salima Ismail, Gilles Karsenty, Emmanuel Chartier-Kastler, Olivier Cussenot, Eva Compérat, Morgan Rouprêt, Véronique Phé
AIM: To perform a systematic review of the literature regarding epidemiology, diagnosis, management and prognosis of bladder cancer in the neuro-urological patient population, in order to serve as a basis for future recommendations and research. METHODS: A systematic review was performed according to the PRISMA-Preferred Reporting Items for Systematic Reviews and Meta-Analyzes Statement. Embase was searched for studies providing data on epidemiology, diagnosis, management and prognosis of bladder cancer in neuro-urological patients...
November 23, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29167898/factors-associated-with-failure-of-adult-strabismus-20-questionnaire-scores-to-improve-following-strabismus-surgery
#8
Sarah R Hatt, David A Leske, Kemuel L Philbrick, Jonathan M Holmes
Importance: Health-related quality of life (HRQOL) typically improves following strabismus surgery. Nevertheless, for some patients, HRQOL does not improve, and reasons for this are unknown. Objective: To identify factors associated with failure of adult strabismus-20 (AS-20) HRQOL scores to improve following strabismus surgery. Design, Setting, and Participants: Prospective observational case series at the Mayo Clinic, Rochester, Minnesota, comprising 276 adults, between July 2012 and August 2016...
November 22, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29167866/prevalence-of-prior-cancer-among-persons-newly-diagnosed-with-cancer-an-initial-report-from-the-surveillance-epidemiology-and-end-results-program
#9
Caitlin C Murphy, David E Gerber, Sandi L Pruitt
Importance: The US cancer survivor population is rapidly growing. Cancer survivors are frequently excluded from cancer clinical trials and observational research. Objective: To examine prevalence of prior cancer among individuals newly diagnosed with cancer. Design, Setting, and Participants: Linked observations across the population-based Surveillance, Epidemiology, and End Results (SEER) program of cancer registries (1975-2013) for 740 990 persons newly diagnosed with cancer from January 2009 through December 2013...
November 22, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29167777/age-and-spatial-peculiarities-of-non-neoplastic-diseases-of-the-skin-and-subcutaneous-tissue-in-kazakhstan-2003-2015
#10
Nurbek Igissinov, Dariyana Kulmirzayeva, Zarina Bilyalova, Gulnur Akpolatova, Marzya Mamyrbayeva, Galina Zhumagaliyeva
Background: Arrangement of effective management aimed at improving dermatological services and consistent care of patients with skin diseases depends on understanding the epidemiological situation. Methods: This retrospective study presents an epidemiological assessment of non-neoplastic skin and subcutaneous tissue diseases in Kazakhstan registered in 2003-2015. Results: The yearly incidence rate of the diseases among the whole population was in average 3,341...
November 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29167684/demographic-profile-of-non-odontogenic-jaw-lesions-in-an-iranian-population-a-30-year-archive-review
#11
Fereshteh Baghai Naini, Pouyan Aminishakib, Maedeh Ghorbanpour, Mohammad Mehdi Vakili, Mohammad Javad Kharazifard
Objectives: The frequency of non-odontogenic lesions of the jawbones is lower than that of odontogenic lesions; however, study of the epidemiologic data of these lesions is required for health care programs. This study aimed to assess the relative frequency and demographic profile of non-odontogenic jaw lesions in an Iranian population over a 30-year period. Materials and Methods: This archive review was performed using demographic and biopsy information of all patients with non-odontogenic lesions of the jawbones submitted to the Oral Pathology Department of Dental School of Tehran University of Medical Sciences from 1984 to 2014...
May 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29167501/dengue-fatal-cases-present-virus-specific-hmgb1-response-in-peripheral-organs
#12
Edson R A Oliveira, Tiago F Póvoa, Gerard J Nuovo, Diego Allonso, Natália G Salomão, Carlos A Basílio-de-Oliveira, Luiz H M Geraldo, Celina G Fonseca, Flávia R S Lima, Ronaldo Mohana-Borges, Marciano V Paes
Dengue is an important infectious disease that presents high incidence and yields a relevant number of fatal cases (about 20,000) every year worldwide. Despite its epidemiological relevance, there are many knowledge gaps concerning dengue pathogenesis, especially with regards to the circumstances that drive a mild clinical course to a severe disease. In this work, we investigated the participation of high mobility group box 1 (HMGB1), an important modulator of inflammation, in dengue fatal cases. Histopathological and ultrastructural analyses revealed that liver, lung and heart post-mortem samples were marked by tissue abnormalities, such as necrosis and apoptotic cell death...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167337/differential-immunodominance-hierarchy-of-cd8-t-cell-responses-in-hla-b-27-05-and-b-27-02-mediated-control-of-hiv-1-infection
#13
Emily Adland, Matilda Hill, Nora Lavandier, Anna Csala, Anne Edwards, Fabian Chen, Marek Radkowski, Justyna D Kowalska, Dimitrios Paraskevis, Angelos Hatzakis, Humberto Valenzuela-Ponce, Katja Pfafferott, Ian Williams, Pierre Pellegrino, Persephone Borrow, Masahiko Mori, Jürgen Rockstroh, Julia G Prado, Beatriz Mothe, Judith Dalmau, Javier Martinez-Picado, Gareth Tudor-Williams, John Frater, Anette Stryhn, Soren Buus, Gustavo Reyes Teran, Simon Mallal, Mina John, Susan Buchbinder, Gregory Kirk, Jeffrey Martin, Nelson Michael, Jacques Fellay, Steve Deeks, Bruce Walker, Santiago Avila-Rios, David Cole, Christian Brander, Mary Carrington, Philip Goulder
The well-characterised association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8+ T-cell responses towards the conserved Gag 263-272 ('KK10') and Pol 901-909 'KY9' epitopes. We here studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely-related HLA-B*27:02 on the HIV-specific CD8+ T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that both HLA-B*27:02 and HLA-B*27:05 associate with slower disease progression and lower viral loads...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29167212/cardiovascular-disease-cancer-and-mortality-among-people-with-type-2-diabetes-and-alcoholic-or-nonalcoholic-fatty-liver-disease-hospital-admission
#14
Sarah H Wild, Jeremy J Walker, Joanne R Morling, David A McAllister, Helen M Colhoun, Bassam Farran, Stuart McGurnaghan, Rory McCrimmon, Stephanie H Read, Naveed Sattar, Christopher D Byrne
OBJECTIVE: To describe associations between alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) hospital admission and cardiovascular disease (CVD), cancer, and mortality in people with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We performed a retrospective cohort study by using linked population-based routine data from diabetes registry, hospital, cancer, and death records for people ages 40-89 years diagnosed with T2DM in Scotland between 2004 and 2013 who had one or more hospital admission records...
November 22, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29167060/aging-process-adherence-to-mediterranean-diet-and-nutritional-status-in-a-large-cohort-of-nonagenarians-effects-on-endothelial-progenitor-cells
#15
F Cesari, F Sofi, R Molino Lova, F Vannetti, G Pasquini, F Cecchi, R Marcucci, A M Gori, C Macchi
BACKGROUND AND AIM: Adherence to the Mediterranean Diet (MD) has been associated with a longer and better life. The aim of this study was to examine the effects of adherence to the MD, and of nutritional habits on endothelial progenitor (EPCs) and circulating progenitor (CPCs) cells in a cohort of nonagenarians enrolled within the Mugello Study, an epidemiological study aimed at investigating both clinically relevant geriatric items and various health issues, including those related to nutritional status...
November 20, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29166976/clinical-laboratory-and-epidemiological-aspects-of-hpv-infection-in-a-low-income-population-from-south-bahia-brazil
#16
S R Gadelha, D M V Soares-Barreto, G B Costa, V C N Leal, L G S Gomes, U R Santos, G C S Ferreira, L D Carvalho, S M V Soraes-Almeida, M A G Mello, A P M Mariano, S M B Sousa, A R Vago, L J Marin
The aim of this study was to determine the prevalence and risk factors for human papillomavirus (HPV) infection in the Southern region of the State of Bahia, evaluating the performance of alternative complementary methods for cervical lesion detection. Cervical samples from women who attended healthcare units were collected and diagnosed by visual inspection, cervical cytology and nested polymerase chain reaction (PCR). Moreover, hemi-nested PCR was performed to detect different HPV genotypes. The prevalence of HPV infection was 47·7%, with genotype 16 detected in most cases...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29166906/anaphylaxis-in-an-emergency-care-setting-a-one-year-prospective-study-in-children-and-adults
#17
Athamaica Ruiz Oropeza, Annmarie Lassen, Susanne Halken, Carsten Bindslev-Jensen, Charlotte G Mortz
BACKGROUND: Current data on anaphylaxis is based on retrospective and register based studies. The objective of this study was to describe the epidemiology of anaphylaxis in a 1 year prospective study at the emergency care setting, Odense University Hospital, Denmark (2013-2014). METHODS: Prospective study at the emergency care setting, Odense University Hospital, Denmark (2013-2014). To identify anaphylaxis cases, records from all patients with clinical suspicion on anaphylaxis or a related diagnosis according to the International Classification of Diseases 10 and from patients treated at the emergency care setting or at prehospital level with adrenaline, antihistamines or glucocorticoids were reviewed daily...
November 22, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29166870/recruiting-former-melanoma-patients-via-hospitals-in-comparison-to-office-based-dermatologists-in-a-register-based-cohort-study-that-required-indirect-contact
#18
S R Zeissig, V Weyer-Elberich, K Emrich, H Binder, S Fischbeck, B H Imruck, P Friedrich-Mai, M E Beutel, M Blettner
BACKGROUND: There are detailed reviews about different recruitment strategies, but not with regard to differences between recruitment of hospital-based versus office-based physicians. Within this study, the two different recruitment schemes are compared. Advantages and disadvantages of different ways of recruitment in registry-based studies are discussed. METHODS: In a cross-sectional cancer-registry-based study, long-term melanoma patients were contacted by dermatologists rather than directly by the registry on the basis of the legal situation...
November 22, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29166403/integration-of-molecular-typing-results-into-tuberculosis-surveillance-in-germany-a-pilot-study
#19
Marta Andrés, Elke Göhring-Zwacka, Lena Fiebig, Martin Priwitzer, Elvira Richter, Sabine Rüsch-Gerdes, Walter Haas, Stefan Niemann, Bonita Brodhun
An integrated molecular surveillance for tuberculosis (TB) improves the understanding of ongoing TB transmission by combining molecular typing and epidemiological data. However, the implementation of an integrated molecular surveillance for TB is complex and requires thoughtful consideration of feasibility, demand, public health benefits and legal issues. We aimed to pilot the integration of molecular typing results between 2008 and 2010 in the German Federal State of Baden-Württemberg (population 10.88 Million) as preparation for a nationwide implementation...
2017: PloS One
https://www.readbyqxmd.com/read/29165706/cholera-epidemics-of-the-past-offer-new-insights-into-an-old-enemy
#20
Matthew Phelps, Mads Linnet Perner, Virginia E Pitzer, Viggo Andreasen, Peter K M Jensen, Lone Simonsen
Background: Although cholera is considered the quintessential long-cycle waterborne disease, studies have emphasized the existence of short-cycle (food, household) transmission. We investigated singular Danish cholera epidemics (1853) to elucidate epidemiological parameters and modes of spread. Methods: Using time series data from cities with different water systems, we estimated the intrinsic transmissibility (R0). Accessing cause-specific mortality data we studied clinical severity, age-specific impact...
November 20, 2017: Journal of Infectious Diseases
keyword
keyword
33555
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"