Xiaojing Zhai, Lin Ai, Dandan Chen, Dongyu Zhou, Yi Han, Ran Ji, Mengfan Hu, Qing Wang, Moruo Zhang, Yuxin Wang, Chunyan Zhang, Jun-Xia Yang, Ankang Hu, He Liu, Jun-Li Cao, Hongxing Zhang
Despite women representing most of those affected by major depression, preclinical studies have focused almost exclusively on male subjects, partially due to a lack of ideal animal paradigms. As the persistent need regarding the sex balance of neuroscience research and female-specific pathology of mental disorders surges, the establishment of natural etiology-based and systematically validated animal paradigms for depression with female subjects becomes an urgent scientific problem. This study aims to establish, characterize, and validate a "Multiple Integrated Social Stress (MISS)" model of depression in female C57BL/6J mice by manipulating and integrating daily social stressors that females are experiencing...
January 2024: Neurobiology of Disease