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https://www.readbyqxmd.com/read/28106757/new-enzyme-inhibitory-triterpenoid-from-marine-macro-brown-alga-padina-boergesenii-allender-kraft
#1
Liaqat Ali, Abdul Latif Khan, Muhammad Al-Broumi, Rashid Al-Harrasi, Lubna Al-Kharusi, Javid Hussain, Ahmed Al-Harrasi
In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga, Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule...
January 18, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28105601/gordonia-isolation-and-identification-in-clinical-samples-and-role-in-biotechnology
#2
REVIEW
Fatemeh Andalibi, Mehdi Fatahi-Bafghi
Gordonia spp. are members of the actinomycete family, and the environment, especially soil, is the natural habitat of this genus of bacteria. Gordonia spp. are important for two aspects: first, some Gordonia species cause a broad spectrum of diseases in healthy and immunocompromised individuals; second, these bacteria are capable of producing useful secondary metabolites, which may be used in various industries; therefore, discrimination of the genus Gordonia from other genera in the actinomycete family is important...
January 20, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28105507/worldwide-poly-phenol-intake-assessment-methods-and-identified-gaps
#3
REVIEW
Paula Pinto, Cláudia N Santos
INTRODUCTION: (Poly)phenols (PPs) are plant secondary metabolites widely distributed in dietary sources, and several evidences show that consumption of PP has a positive impact in human health. However, the correct estimation of food intake and the estimation of PP content of foods are essential to associate PPs intake with health effects. PURPOSE: This review aimed to gather information from several studies on PP intake in different countries, compare methods used for both assessment of food intake and PP quantification and highlight existing gaps and future directions...
January 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28103799/comparative-rna-seq-based-transcriptomic-analysis-of-bud-dormancy-in-grape
#4
Muhammad Khalil-Ur-Rehman, Long Sun, Chun-Xia Li, Muhammad Faheem, Wu Wang, Jian-Min Tao
BACKGROUND: Bud dormancy is an important biological phenomenon of perennial plants that enables them to survive under harsh environmental circumstances. Grape (Vitis vinifera) is one of the most grown fruit crop worldwide; however, underlying mechanisms involved in grape bud dormancy are not yet clear. This work was aimed to explore the underlying molecular mechanism regulating bud dormancy in grape. RESULTS: We have performed transcriptome and differential transcript expression analyses of "Shine Muscat" grape buds using the Illumina RNA-seq system...
January 19, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28103742/secondary-metabolites-with-antiproliferative-effects-from-albizia-glaberrima-var-glabrescens-oliv-mimosoideae
#5
Ghislain Wabo Fotso, Justin Kamga, Bathelemy Ngameni, Shota Uesugi, Misa Ohno, Ken-Ichi Kimura, Hiroyuki Momma, Eunsang Kwon, Hiroshi Furuno, Yoshihito Shiono, Simo K Ingrid, Samuel O Yeboah, Bonaventure T Ngadjui
A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3',4', 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data...
January 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28103011/discovery-of-a-phosphonoacetic-acid-derived-natural-product-by-pathway-refactoring
#6
Todd S Freestone, Kou-San Ju, Bin Wang, Huimin Zhao
The activation of silent natural product gene clusters is a synthetic biology problem of great interest. As the rate at which gene clusters are identified outpaces the discovery rate of new molecules, this unknown chemical space is rapidly growing, as too are the rewards for developing technologies to exploit it. One class of natural products that has been underrepresented is phosphonic acids, which have important medical and agricultural uses. Hundreds of phosphonic acid biosynthetic gene clusters have been identified encoding for unknown molecules...
January 19, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28100450/a-2-oxoglutarate-dependent-dioxygenase-mediates-the-biosynthesis-of-glucoraphasatin-in-radish
#7
Tomohiro Kakizaki, Hiroyasu Kitashiba, Zhongwei Zou, Feng Li, Nobuko Fukino, Takayoshi Ohara, Takeshi Nishio, Masahiko Ishida
Glucosinolates (GSLs) are secondary metabolites whose degradation products confer intrinsic flavors and aromas to Brassicaceae vegetables. Several structures of GSLs are known in the Brassicaceae, and the biosynthetic pathway and regulatory networks have been elucidated in Arabidopsis thaliana. GSLs are precursors of chemical defense substances against herbivorous pests. Specific GSLs can act as feeding blockers or stimulants, depending on the pest species. Natural selection has led to diversity in the GSL compositions even within individual species...
January 18, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28100172/integrated-genomics-based-mapping-reveals-the-genetics-underlying-maize-flavonoid-biosynthesis
#8
Min Jin, Xuehai Zhang, Mingchao Zhao, Min Deng, Yuanhao Du, Yang Zhou, Shouchuang Wang, Takayuki Tohge, Alisdair R Fernie, Lothar Willmitzer, Yariv Brotman, Jianbing Yan, Weiwei Wen
BACKGROUND: Flavonoids constitute a diverse class of secondary metabolites which exhibit potent bioactivities for human health and have been indicated to play an important role in plant development and defense. However, accumulation and variation of flavonoid content in diverse maize lines and the genes responsible for their biosynthesis in this important crop remain largely unknown. In this study, we combine genetic mapping, metabolite profiling and gene regulatory network analysis to further enhance understanding of the maize flavonoid pathway...
January 18, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28098865/endophytic-fungi-from-mangrove-inhibit-lung-cancer-cell-growth-and-angiogenesis-in-vitro
#9
Xin Liu, Xin Wu, Yuefan Ma, Wenzhang Zhang, Liang Hu, Xiaowei Feng, Xiangyong Li, Xudong Tang
The secondary metabolites of mangrove-derived endophytic fungi contain multiple substances with novel structures and biological activities. In the present study, three types of mangrove plants, namely Kandelia candel, Rhizophora stylosa and Rhizophoraceae from Zhanjiang region including the leaves, roots and stems were collected, and endophytic fungi were isolated, purified and identified from these mangrove plants. MTT assay was used to observe the effects of the isolated endophytic fungi on the growth of A549 and NCI-H460 lung cancer cells...
January 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098796/comparative-metabolite-profiling-of-triterpenoid-saponins-and-flavonoids-in-flower-color-mutations-of-primula-veris-l
#10
Lysanne Apel, Dietmar R Kammerer, Florian C Stintzing, Otmar Spring
Primula veris L. is an important medicinal plant with documented use for the treatment of gout, headache and migraine reaching back to the Middle Ages. Triterpenoid saponins from roots and flowers are used in up-to-date phytotherapeutic treatment of bronchitis and colds due to their expectorant and secretolytic effects. In addition to the wild type plants with yellow petals, a red variant and an intermediate orange form of Primula veris L. have recently been found in a natural habitat. The secondary metabolite profiles of roots, leaves and flowers of these rare variants were investigated and compared with the wild type metabolome...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098779/unravelling-the-diversity-of-the-cyclopiazonic-acid-family-of-mycotoxins-in-aspergillus-flavus-by-uhplc-triple-tof-hrms
#11
Valdet Uka, Geromy G Moore, Natalia Arroyo-Manzanares, Dashnor Nebija, Sarah De Saeger, José Diana Di Mavungu
Cyclopiazonic acid (α-cyclopiazonic acid, α-CPA) is an indole-hydrindane-tetramic acid neurotoxin produced by various fungal species, including the notorious food and feed contaminant Aspergillus flavus. Despite its discovery in A. flavus cultures approximately 40 years ago, its contribution to the A. flavus mycotoxin burden is consistently minimized by our focus on the more potent carcinogenic aflatoxins also produced by this fungus. Here, we report the screening and identification of several CPA-type alkaloids not previously found in A...
January 13, 2017: Toxins
https://www.readbyqxmd.com/read/28098172/structural-diversity-of-anti-pancreatic-cancer-capsimycins-identified-in-mangrove-derived-streptomyces-xiamenensis-318-and-post-modification-via-a-novel-cytochrome-p450-monooxygenase
#12
He-Lin Yu, Shu-Heng Jiang, Xu-Liang Bu, Jia-Hua Wang, Jing-Yi Weng, Xiao-Mei Yang, Kun-Yan He, Zhi-Gang Zhang, Ping Ao, Jun Xu, Min-Juan Xu
Polycyclic tetramate macrolactams (PTMs) were identified as distinct secondary metabolites of the mangrove-derived Streptomyces xiamenensis 318. Together with three known compounds-ikarugamycin (1), capsimycin (2) and capsimycin B (3)-two new compounds, capsimycin C (4) with trans-diols and capsimycin D (5) with trans-configurations at C-13/C-14, have been identified. The absolute configurations of the tert/tert-diols moiety was determined in 4 by NMR spectroscopic analysis, CD spectral comparisons and semi-synthetic method...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097384/stress-response-physiology-of-thermophiles
#13
REVIEW
Preeti Ranawat, Seema Rawat
Thermo (or hyperthermo) philic microorganisms are ubiquitous having a wide range of habitats from freshly fallen snow to pasteurized milk to geothermal areas like hot springs. The variations in physicochemical conditions, viz., temperature, pH, nutrient availability and light intensity in the habitats always pose stress conditions for the inhabitants leading to slow growth or cell death. The industrial processes used for harvesting secondary metabolites such as enzymes, toxins and organic acids also create stressed environments for thermophiles...
January 17, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28095778/the-pangenome-of-antarctic-pseudoalteromonas-bacteria-evolutionary-and-functional-insights
#14
Emanuele Bosi, Marco Fondi, Valerio Orlandini, Elena Perrin, Isabel Maida, Donatella de Pascale, Maria Luisa Tutino, Ermenegilda Parrilli, Angelina Lo Giudice, Alain Filloux, Renato Fani
BACKGROUND: Pseudoalteromonas is a genus of ubiquitous marine bacteria used as model organisms to study the biological mechanisms involved in the adaptation to cold conditions. A remarkable feature shared by these bacteria is their ability to produce secondary metabolites with a strong antimicrobial and antitumor activity. Despite their biotechnological relevance, representatives of this genus are still lacking (with few exceptions) an extensive genomic characterization, including features involved in the evolution of secondary metabolites production...
January 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28093998/potential-of-plant-alkaloids-as-antipyretic-drugs-of-future
#15
Imad Ahmad, Haroon Khan, Anwar Ul-Hassan Gilani, Mohammad A Kamal
Fever or Pyrexia means abnormal rise in body temperature above the usual range of normal in response to a variety of infectious, immunological and neoplastic stimuli. To normalize these febrile conditions, several synthetic agents are in clinical practice such as acetaminophen, ibuprofen, and aspirin. However, they are having many side effects which sometimes challenge their applications. The various sources are under investigation worldwide to overcome issues of unwanted effects and to better therapeutic response...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093995/glycosides-as-possible-lead-antimalarial-in-new-drug-discovery-future-perspectives
#16
Marya, Haroon Khan, Izhar Ahmad
Malaria remains one of the major public health problems worldwide and is responsible for a large number of morbidity and mortality. Especially, in the third world countries, it is still alarming. The development of drug-resistant to Plasmodium falciparum strains has further degraded the overall situation. However, a limited number of effective drugs available emphasizes how essential it is to establish new anti-malarial compounds. New antimalarial agents with distinctive structures and mechanism of action from the natural origin are thus immediately required to treat sensitive and drug-resistant strains of malaria...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093838/fusaric-acid-contributes-to-virulence-of-fusarium-oxysporum-on-plant-and-mammalian-hosts
#17
Cristina López-Díaz, Vahid Rahjoo, Michael Sulyok, Veronica Ghionna, Adela Martín-Vicente, Javier Capilla, Antonio Di Pietro, Manuel S López-Berges
Fusaric acid (FA) is among the oldest identified secondary metabolites produced by Fusarium species, known for a long time to display strong phytotoxicity and moderate toxicity to animal cells; however, the cellular targets of FA as well as its function in fungal pathogenicity remain unknown. Here, we investigated the role of FA in Fusarium oxysporum, a soil-borne cross-kingdom pathogen that causes vascular wilt on more than a hundred plant species and opportunistic infections in humans. Targeted deletion of fub1, encoding a predicted orthologue of the polyketide synthase involved in FA biosynthesis in F...
January 17, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28092947/pyrrolizidine-alkaloids-metabolic-activation-pathways-leading-to-liver-tumor-initiation
#18
Peter P Fu
Pyrrolizidine alkaloids (PAs) and PA N-oxides are a class of phytochemical carcinogens contained in over 6000 plant species spread around the world. It has been estimated that approximately half of the 660 PAs and PA N-oxides that have been characterized are cytotoxic, genotoxic, and tumorigenic. It was recently determined that a genotoxic mechanism of liver tumor initiation mediated by PA-derived DNA adducts is a common metabolic activation pathway of a number of PAs. We proposed this set of PA-derived DNA adducts could be a common biological biomarker of PA exposure and a potential biomarker of PA-induced liver tumor formation...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28092065/impact-of-celecoxib-on-inflammation-during-cancer-surgery-a-randomized-clinical-trial
#19
Jonathan G Hiller, Shienny Sampurno, Rosemary Millen, Niketh Kuruvilla, Kwok M Ho, Rob Ramsay, Bernhard Riedel
PURPOSE: During cancer surgery, prostaglandin-mediated inflammation may promote and activate micrometastatic disease with a consequent increase in long-term cancer recurrence. Cyclooxygenase-2 inhibitors, known to have anti-proliferative properties, may offset such perioperative perturbation. We investigated the effectiveness of these agents to minimize inflammatory changes during cancer surgery. METHODS: Following ethics approval, 32 patients who were to undergo major intracavity cancer surgery were enrolled in this prospective, randomized, clinical trial...
January 13, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28091822/does-the-growth-differentiation-balance-hypothesis-explain-allocation-to-secondary-metabolites-in-combretum-apiculatum-an-african-savanna-woody-species
#20
Dawood Hattas, Peter F Scogings, Riitta Julkunen-Tiitto
The growth differentiation balance hypothesis (GDBH) provides a framework that predicts a trade-off between costs of secondary metabolites (SMs) relative to the demand for photosynthate by growth. However, this hypothesis was developed using empirical evidence from plant species in northern boreal and temperate systems, leaving its applicability to species under different abiotic and biotic conditions questionable and generalizations problematic. The objective of this study was to investigate whether the GDBH explains allocation to SMs in the deciduous African savanna woody species C...
January 14, 2017: Journal of Chemical Ecology
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