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https://www.readbyqxmd.com/read/28631639/prevalence-of-clostridium-difficile-infection-among-the-patients-attending-a-tertiary-care-teaching-hospital
#1
Lavanya Segar, Joshy M Easow, Sreenivasan Srirangaraj, Mohammad Hanifah, Noyal M Joseph, K S Seetha
BACKGROUND: Clostridium difficile, a most important nosocomial enteric pathogen, is recognized globally as responsible for antibiotic-associated diarrhea and colitis. It is associated with considerable morbidity and mortality due to widespread use of antibiotics. AIMS: The study was done to determine the prevalence of C. difficile infection (CDI) among the patients attending a tertiary care teaching hospital in Puducherry. SETTINGS AND DESIGN: We performed a prospective cohort study in Mahatma Gandhi Medical College and Research Institute...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28615471/clostridium-difficile-pcr-cycle-threshold-predicts-free-toxin
#2
Fiona Senchyna, Rajiv L Gaur, Saurabh Gombar, Cynthia Y Truong, Lee F Schroeder, Niaz Banaei
Background. There is no stand-alone Clostridium difficile diagnostic that can sensitively and rapidly detect fecal free toxins. We investigated the performance of C. difficile PCR cycle threshold (CT) for predicting free toxin status.Method. Consecutive stool samples (n=312) positive for toxigenic C. difficile with the GeneXpert C.diff Epi tcdB PCR assay were tested with the rapid membrane C. DIFF QUIK CHEK COMPLETE immunoassay (RMEIA). RMEIA toxin-negative samples were tested with the cell cytotoxicity neutralization assay (CCNA) and tgcBIOMICS ELISA...
June 14, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28603640/prevalence-and-molecular-epidemiology-of-clostridium-difficile-infection-in-indonesia
#3
D A Collins, M H Gasem, T H Habibie, I G Arinton, P Hendriyanto, A P Hartana, T V Riley
Clostridium difficile has not been studied in detail in Asia, particularly Southeast Asia. We thus performed a prevalence study across four hospitals in Central Java province, Indonesia. Stool samples were collected from patients with diarrhoea and tested by enzyme immunoassay for glutamate dehydrogenase (GDH) and toxin A/B (C DIFF QUIK CHEK COMPLETE, TechLab). Specimens were cultured and molecular typing was performed. In total, 340 samples were tested, of which 70 (20.6%) were GDH positive, with toxin detected in 19 (5...
July 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28596946/non-high-density-lipoprotein-fractions-are-strongly-associated-with-the-presence-of-metabolic-syndrome-independent-of-obesity-and-diabetes-a-population-based-study-among-iranian-adults
#4
Saeed Ghodsi, Alipasha Meysamie, Mehrshad Abbasi, Reza Ghalehtaki, Alireza Esteghamati, Masoud M Malekzadeh, Fereshteh Asgari, Mohammad M Gouya
BACKGROUND: Non-HDL-C as a valuable predictor of premature atherosclerosis, coronary events like first Myocardial infarction and cardiovascular mortality has a high accuracy of measurement both in fasting and non-fasting individuals. Metabolic syndrome (MetS) can promote the development of diabetes mellitus, endothelial dysfunction and atherosclerosis. A common pathway for cross linking of metabolic abnormalities and non-HDL-C has been suggested. In this study we aimed to describe the potential association between non-HDL cholesterol fractions and metabolic syndrome...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28577545/the-effect-of-a-prenatal-lifestyle-intervention-on-glucose-metabolism-results-of-the-norwegian-fit-for-delivery-randomized-controlled-trial
#5
Linda R Sagedal, Ingvild Vistad, Nina C Øverby, Elling Bere, Monica K Torstveit, Hilde Lohne-Seiler, Elisabet R Hillesund, Are Pripp, Tore Henriksen
BACKGROUND: The effectiveness of prenatal lifestyle intervention to prevent gestational diabetes and improve maternal glucose metabolism remains to be established. The Norwegian Fit for Delivery (NFFD) randomized, controlled trial studied the effect of a combined lifestyle intervention provided to a general population, and found significantly lower gestational weight gain among intervention participants but no improvement in obstetrical outcomes or the proportion of large infants. The aim of the present study is to examine the effect of the NFFD intervention on glucose metabolism, including an assessment of the subgroups of normal-weight and overweight/obese participants...
June 2, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28576711/safety-and-efficacy-of-antibacterial-prophylaxis-after-craniotomy-a-decision-model-analysis
#6
Amal F Alotaibi, Rania A Mekary, Hasan A Zaidi, Timothy R Smith, Ankur Pandya
BACKGROUND: Antibiotic prophylaxis has revolutionized the safety of neurosurgical procedures in the last century. Today, the clinician's drug of choice prior surgery is often based on the antibiotic's resistance profile and drug-induced complications. METHODS: A decision tree model was developed to compare cefazolin (cephalosporin), vancomycin, or their combination on 90-day mortality post-craniotomy. We modeled the infection type (methicillin-sensitive, methicillin-resistant, or other organisms), antibiotic-related complications that could affect mortality (e...
May 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28431306/difference-optimization-automatic-correction-of-relative-frequency-and-phase-for-mean-non-edited-and-edited-gaba-1-h-mega-press-spectra
#7
Marianne Cleve, Martin Krämer, Alexander Gussew, Jürgen R Reichenbach
Phase and frequency corrections of magnetic resonance spectroscopic data are of major importance to obtain reliable and unambiguous metabolite estimates as validated in recent research for single-shot scans with the same spectral fingerprint. However, when using the J-difference editing technique (1)H MEGA-PRESS, misalignment between mean edited (ON‾) and non-edited (OFF‾) spectra that may remain even after correction of the corresponding individual single-shot scans results in subtraction artefacts compromising reliable GABA quantitation...
April 7, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28297240/analytical-comparison-between-two-hematological-analyzer-systems-cal-8000-vs-xn-9000
#8
COMPARATIVE STUDY
S Buoro, T Mecca, M Seghezzi, B Manenti, G Azzarà, P Dominoni, A Crippa, C Ottomano, G Lippi
INTRODUCTION: This study was aimed to compare the analytical performance of traditional and new parameters and morphological flags of CAL-8000 and XN-9000. The automated differential leukocyte count (DIFF profile) and morphological flags were compared with optical microscopy (OM). METHODS: A total of 1025 peripheral blood samples, collected in K3 EDTA tubes, were analyzed by CAL-8000, by XN-9000, and by OM. Within-run imprecision was performed in low cellularity samples...
April 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28215602/clostridium-difficile-infection-in-acute-flares-of-inflammatory-bowel-disease-a-prospective-study
#9
Harry Sokol, Valérie Lalande, Cecilia Landman, Anne Bourrier, Isabelle Nion-Larmurier, Sylvie Rajca, Julien Kirchgesner, Philippe Seksik, Jacques Cosnes, Frédéric Barbut, Laurent Beaugerie
OBJECTIVES: Clostridium difficile infection (CDI) is a common complication in inflammatory bowel disease (IBD) and has been associated with poor IBD outcome. The aims of our study were to look for predictive factors of CDI in patients hospitalized for IBD flare and to evaluate a rapid testing strategy in this population. METHODS: Consecutive patients hospitalized for IBD flare in Saint-Antoine Hospital (Paris, France) were prospectively tested for CDI with a defined strategy involving rapid testing and reference methods...
June 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28181032/comprehensive-evaluation-of-chemiluminescent-immunoassays-for-the-laboratory-diagnosis-of-clostridium-difficile-infection
#10
A Makristathis, I Zeller, D Mitteregger, M Kundi, A M Hirschl
For the microbiological diagnosis of a Clostridium (C.) difficile infection (CDI), a two-test algorithm consisting of a C. difficile glutamate dehydrogenase (GDH)-immunoassay followed by a toxin-immunoassay in positive cases is widely used. In this study, two chemiluminescent immunoassays (CLIAs), one for GDH and the other for the toxins A and B, have been evaluated systematically using appropriate reference methods. Three-hundred diarrhoeal stool specimens submitted for CDI diagnosis were analysed by the LIAISON CLIAs (DiaSorin)...
February 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28177534/laboratory-diagnosis-of-clostridium-difficile-infection-comparison-of-techlab-c-diff-quik-chek-complete-xpert-c-difficile-and-multistep-algorithmic-approach
#11
Ja Young Seo, Ji Hun Jeong, Kyung Hee Kim, Jeong-Yeal Ahn, Pil-Whan Park, Yiel-Hea Seo
BACKGROUND: Clostridium difficile is a major pathogen responsible for nosocomial infectious diarrhea. We explored optimal laboratory strategies for diagnosis of C. difficile infection (CDI) in our clinical settings, a 1400-bed tertiary care hospital. METHODS: Using 191 fresh stool samples from adult patients, we evaluated the performance of Xpert C. difficile (Xpert CD), C. diff Quik Chek Complete (which simultaneously detects glutamate dehydrogenase [GDH] and C...
February 8, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28122653/delivery-as-trauma-a-prospective-time-cohort-study-of-maternal-and-perinatal-mortality-in-rural-cambodia
#12
Chandy Houy, Sam Ol Ha, Margit Steinholt, Eystein Skjerve, Hans Husum
OBJECTIVE: The majority of maternal and perinatal deaths are preventable, but still women and newborns die due to insufficient Basic Life Support in low-resource communities. Drawing on experiences from successful wartime trauma systems, a three-tier chain-of-survival model was introduced as a means to reduce rural maternal and perinatal mortality. METHODS: A study area of 266 villages in landmine-infested Northwestern Cambodia were selected based on remoteness and poverty...
January 26, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28059711/t1-recovery-is-predominantly-found-in-black-holes-and-is-associated-with-clinical-improvement-in-patients-with-multiple-sclerosis
#13
C Thaler, T D Faizy, J Sedlacik, B Holst, K Stürner, C Heesen, J-P Stellmann, J Fiehler, S Siemonsen
BACKGROUND AND PURPOSE: Quantitative MR imaging parameters help to evaluate disease progression in multiple sclerosis and increase correlation with clinical disability. We therefore hypothesized that T1 values might be a marker for ongoing tissue damage or even remyelination and may help increase clinical correlation. MATERIALS AND METHODS: MR imaging was performed in 17 patients with relapsing-remitting MS at baseline and after 12 months of starting immunotherapy with dimethyl fumarate...
November 10, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28046282/su-g-tep4-12-individual-beam-qa-for-a-robotic-radiosurgery-system-using-a-scintillator-cone
#14
C McGuinness, M Descovich, A Sudhyadhom
PURPOSE: The targeting accuracy of the Cyberknife system is measured by end-to-end tests delivering multiple isocentric beams to a point in space. While the targeting accuracy of two representative beams can be determined by a Winston-Lutz-type test, no test is available today to determine the targeting accuracy of each clinical beam. We used a scintillator cone to measure the accuracy of each individual beam. METHODS: The XRV-124 from Logos Systems Int'l is a scintillator cone with an imaging system that is able to measure individual beam vectors and a resulting error between planned and measured beam coordinates...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27876339/diagnosis-and-treatment-of-clostridium-difficile-c-diff-colitis-review-of-the-literature-and-a-perspective-in-gynecologic-oncology
#15
REVIEW
Kristin N Taylor, Michael T McHale, Cheryl C Saenz, Steven C Plaxe
Clostridium difficile infection (CDI) is a major cause of nosocomial diarrhea with the potential for significant morbidity and mortality. Colonization in a susceptible individual, with risk factors such as prior antibiotic use, advanced age, or medical comorbidities, may result in symptomatic infection. Although patients with a gynecologic malignancy may be at a higher risk of developing CDI due to an increased likelihood of having one or more risk factors, data do not consistently support the idea that chemotherapy or cancer itself are independently associated with CDI...
February 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27850214/574-extreme-body-mass-indices-are-associated-with-greater-mortality-in-patients-with-c-diff-infections
#16
William McGee, Brian Nathanson, Thomas Higgins
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27812827/a-novel-pathology-based-preoperative-risk-score-to-predict-locoregional-residual-and-distant-disease-and-survival-for-incidental-gallbladder-cancer-a-10-institution-study-from-the-u-s-extrahepatic-biliary-malignancy-consortium
#17
Cecilia G Ethun, Lauren M Postlewait, Nina Le, Timothy M Pawlik, Stefan Buettner, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Linda X Jin, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Nipun Merchant, Kenneth Cardona, Shishir K Maithel
BACKGROUND: This study was designed to develop a more robust predictive model, beyond T-stage alone, for incidental gallbladder cancer (IGBC) for discovering locoregional residual (LRD) and distant disease (DD) at reoperation, and estimating overall survival (OS). T-stage alone is currently used to guide treatment for incidental gallbladder cancer. Residual disease at re-resection is the most important factor in predicting outcomes. METHODS: All patients with IGBC who underwent reoperation at 10 institutions from 2000 to 2015 were included...
May 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27802412/cytographic-changes-on-bc-6800-haematological-analyzer-related-to-the-presence-of-candida-albicans-in-peripheral-blood-a-new-tool-to-suspect-candidemia
#18
Antonio La Gioia, Alessandra Devito, Fabiana Fiorini, Maria Bombara, Patrizia Isola, Barbara Spinale, Lucia Francioni, Domenico Salamone, Paola Marelli, Sabrina Buoro, Marcello Fiorini
BACKGROUND: We studied the quantitative and cytographic changes that the presence of Candida albicans (C. albicans) in peripheral blood (PB) samples causes on the Mindray BC-6800 Haematological Analyzer. METHODS: A simulated in vitro candidemia was obtained by adding a different amount of C. albicans to discarded remnants of PB samples. Quantitative data and cytographic features were evaluated immediately as well as after 120 and 240 min of the yeast addition...
October 31, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27801920/hydralazine-induced-anca-vasculitis-in-the-setting-of-acute-clostridium-difficile-infection
#19
Somwail Rasla, Amr El Meligy, Dragos F Cucu
We report a rare case of Hydralazine-induced ANCA associated glomerulonephritis with alveolar hemorrhage in the setting of acute Clostridium Difficile Infection. A 71-year-old Caucasian woman with hypertension, who was being treated with hydralazine 25 mg twice a day for six years, presented to the hospital with diarrhea, nausea, vomiting and anemia. She had acute kidney injury and urinalysis showed proteinuria, dysmorphic RBCs, and rare RBC cast. She was found to have Clostridium difficile colitis which was successfully treated...
November 1, 2016: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/27752866/physical-activity-maintenance-among-spanish-speaking-latinas-in-a-randomized-controlled-trial-of-an-internet-based-intervention
#20
Sheri J Hartman, Shira I Dunsiger, Beth C Bock, Britta A Larsen, Sarah Linke, Dori Pekmezi, Becky Marquez, Kim M Gans, Andrea S Mendoza-Vasconez, Bess H Marcus
Spanish-speaking Latinas have some of the lowest rates of meeting physical activity guidelines in the U.S. and are at high risk for many related chronic diseases. The purpose of the current study was to examine the maintenance of a culturally and individually-tailored Internet-based physical activity intervention for Spanish-speaking Latinas. Inactive Latinas (N  =  205) were randomly assigned to a 6-month Tailored Physical Activity Internet Intervention or a Wellness Contact Control Internet Group, with a 6-month follow-up...
June 2017: Journal of Behavioral Medicine
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