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https://www.readbyqxmd.com/read/29241190/circrna-expression-profile-in-early-stage-lung-adenocarcinoma-patients
#1
Jiangmin Zhao, Le Li, Qian Wang, Hongxiu Han, Qing Zhan, Ming Xu
BACKGROUND/AIMS: Lung adenocarcinoma, a form of non-small cell lung cancer with high lethality at an advanced stage, is becoming more common in women, non- or never-smokers, and even young adults. At present, there are still no effective early diagnosis methods for patients to be cured in a timely manner. Circular RNAs (circRNAs), which are stable and conserved non-coding RNA in mammalian cells, have been reported to be widely involved in the processes of cancer disease. However, it is still a puzzle as to which specific circRNAs are involved in the development of early-stage lung adenocarcinoma...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241149/a-novel-use-of-3d-printing-model-demonstrates-the-effects-of-deteriorated-trabecular-bone-structure-on-bone-stiffness-and-strength
#2
Meir Max Barak, Margaret Arielle Black
Trabecular bone structure is crucial to normal mechanical behavior of bones. Studies have shown that osteoporosis negatively affects trabecular bone structure, mainly by reducing bone volume fraction (BV/TV) and thus increasing fracture risk. One major limitation in assessing and quantifying the effect of this structural deterioration is that no two trabecular structures are identical. Thus, when we compare a group of healthy bones against a different group of bones that experienced resorption (i.e. decreased BV/TV) we only discover an "average" mechanical effect...
December 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29241061/scfv-modified-graphene-coated-ide-arrays-for-label-free-screening-of-cardiovascular-disease-biomarkers-in-physiological-saline
#3
Lotta E Delle, Vivek Pachauri, Shikha Sharma, Olena Shaforost, Hui Ma, Mohammad Adabi, Rainer Lilischkis, Patrick Wagner, Ronald Thoelen, Norbert Klein, Richard O'Kennedy, Sven Ingebrandt
Fatty-acid binding proteins (FABP) and myeloperoxidases (MPO) are associated with many chronic conditions in humans and considered to be important biomarkers for diagnosis of cardiac diseases. Here we assemble a new electrical biosensor platform based on graphene-coated interdigitated electrode arrays (IDE-arrays) towards ultrafast, label-free screening of heart type-FABP and MPO. Arrays of nanoscale (nanoIDE) and microscale (microIDE) electrode-arrays were fabricated on wafer-scale by combining nanoimprint and photolithography processes...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29241040/a-large-polysaccharide-produced-by-helicobacter-hepaticus-induces-an-anti-inflammatory-gene-signature-in-macrophages
#4
Camille Danne, Grigory Ryzhakov, Maria Martínez-López, Nicholas Edward Ilott, Fanny Franchini, Fiona Cuskin, Elisabeth C Lowe, Samuel J Bullers, J Simon C Arthur, Fiona Powrie
Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host. In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response in the intestine. Here we investigate the interactions between H. hepaticus and host immune cells that may promote mutualism, and the microbe-derived molecule(s) involved...
December 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29241027/when-forensic-odontology-met-biochemistry-multidisciplinary-approach-in-forensic-human-identification
#5
REVIEW
Joe Adserias-Garriga, Christian Thomas, Douglas H Ubelaker, Sara C Zapico
When human remains are found, the priority of the investigation is to ascertain the identity of the deceased. A positive identification is a key factor in providing closure for the family of the deceased; it is also required to issue the death certificate and therefore, to settle legal affairs. Moreover, it is difficult for any forensic investigation involving human remains to be solved without the determination of an identity. Therefore, personal identification is necessary for social, legal and forensic reasons...
December 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29240782/conservation-and-divergence-of-starch-synthase-iii-genes-of-monocots-and-dicots
#6
Bhavya Priyadarshini Mishra, Rajeev Kumar, Amita Mohan, Kulvinder S Gill
Starch Synthase (SS) plays an important role in extending the α-1,4 glucan chains during starch biosynthesis by catalyzing the transfer of the glucosyl moiety from ADP-glucose to the non-reducing end of a pre-existing glucan chain. SS has five distinct isoforms of which SSIII is involved in the formation of longer glucan chain length. Here we report identification and detailed characterization of 'true' orthologs of the well-characterized maize SSIII (ZmSSIII), among six monocots and two dicot species. ZmSSIII orthologs have nucleotide sequence similarity ranging from 56-81%...
2017: PloS One
https://www.readbyqxmd.com/read/29240682/recombinant-prp-and-its-contribution-to-research-on-transmissible-spongiform-encephalopathies
#7
REVIEW
Jorge M Charco, Hasier Eraña, Vanessa Venegas, Sandra García-Martínez, Rafael López-Moreno, Ezequiel González-Miranda, Miguel Ángel Pérez-Castro, Joaquín Castilla
The misfolding of the cellular prion protein (PrPC) into the disease-associated isoform (PrPSc) and its accumulation as amyloid fibrils in the central nervous system is one of the central events in transmissible spongiform encephalopathies (TSEs). Due to the proteinaceous nature of the causal agent the molecular mechanisms of misfolding, interspecies transmission, neurotoxicity and strain phenomenon remain mostly ill-defined or unknown. Significant advances were made using in vivo and in cellula models, but the limitations of these, primarily due to their inherent complexity and the small amounts of PrPSc that can be obtained, gave rise to the necessity of new model systems...
December 14, 2017: Pathogens
https://www.readbyqxmd.com/read/29240531/enhancing-dignity-for-older-inpatients-the-photograph-next-to-the-bed-study
#8
Ruth E Hubbard, Melissa Bak, Jacqueline Watts, David Shum, Angelica Lynch, Nancye M Peel
OBJECTIVES: Older inpatients compromised by illness and cognitive decline may be stripped of physical and cultural identifiers, making them vulnerable to erosion of dignity. This study explored the experiences of patients, carers and clinical staff in response to a simple intervention that could enhance the dignity of care for older inpatients. METHODS: All patients in a rehabilitation ward were encouraged to have a photograph of themselves next to their bed. Of those who participated, focus groups were recruited for patients, family members and staff to explore their reflections...
November 16, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29240395/narrow-band-gap-conjugated-polyelectrolytes
#9
Qiuhong Cui, Guillermo C Bazan
Two essential structural elements define a class of materials called conjugated polyelectrolytes (CPEs). The first is a polymer framework with an electronically delocalized, π-conjugated structure. This component allows one to adjust desirable optical and electronic properties, for example the range of wavelengths absorbed, emission quantum yields, electron affinity, and ionization potential. The second defining feature is the presence of ionic functionalities, which are usually linked via tethers that can modulate the distance of the charged groups relative to the backbone...
December 14, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29239885/the-present-state-of-neurointensivist-training-in-the-united-states-a-comparison-to-other-critical-care-training-programs
#10
Evie G Marcolini, David B Seder, Jordan B Bonomo, Thomas P Bleck, J Claude Hemphill, Lori Shutter, Fred Rincon, Shelly D Timmons, Paul Nyquist
OBJECTIVE: This manuscript describes the state of neurocritical care fellowship training, compares its written standards to those of other critical care fellowship programs, and discusses how programmatic oversight by the United Council for Neurological Subspecialties should evolve to meet American College of Graduate Medical Education standards. This review is a work product of the Society of Critical Care Medicine Neuroscience section and was reviewed and approved by the Council of the Society of Critical Care Medicine...
December 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29239765/immune-responses-transcriptional-and-post-transcriptional-networks-pass-the-baton
#11
Johannes Lichti, Christian Gallus, Elke Glasmacher
Diverse gene regulatory mechanisms impact on immune homeostasis, and a new model now emerges as fundamental in light of recent genome-wide studies. In this picture, transcriptional networks drive functional changes during immune activation, whereas autoregulatory feedback loops of post-transcriptional programs ensure the original cell lineage identity and subsequent immune resolution.
November 24, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/29239717/niveispirillum-lacus-sp-nov-isolated-from-cyanobacterial-aggregates-in-a-eutrophic-lake
#12
Haiyuan Cai, Henglin Cui, Yonghui Zeng, Yanan Wang, Helong Jiang
A bacterial strain, 1-14T, was isolated from cyanobacterial aggregates in a eutrophic lake, Taihu Lake, China. Cells were observed to be slightly curved, rod-shaped, aerobic and Gram-stain-negative. Optimal growth occurred at pH 7.0 (range: 5.0-9.0), 28 °C (range: 20-32 °C) and 0 % (w/v) NaCl (range: 0-1.0 %) in R2A broth. No growth is observed at 37 °C. The cells were found to be positive for oxidase and catalase activities. The major respiratory quinone was ubiquinone Q-10. The major fatty acids (>10 %) were identified as C18 : 1ω6c/C18 : 1ω7c, C16 : 0 3-OH and C18 : 1 2-OH...
December 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29239716/pseudomonas-fluvialis-sp-nov-a-novel-member-of-the-genus-pseudomonas-isolated-from-the-river-ganges-india
#13
Sarabjeet Kour Sudan, Deepika Pal, Bhawana Bisht, Narender Kumar, Vasvi Chaudhry, Prabhu Patil, Girish Sahni, Shanmugam Mayilraj, Srinivasan Krishnamurthi
A bacterial strain, designated ASS-1T, was isolated and identified from a sediment sample of the river Ganges, Allahabad, India. The strain was Gram-stain-negative, formed straw-yellow pigmented colonies, was strictly aerobic, motile with a single polar flagellum, and positive for oxidase and catalase. The major fatty acids were C16 : 1ω7c/ 16 : 1 C16 : 1ω6c, C18 : 1ω7c and C16 : 0. Sequence analysis based on the 16S rRNA gene revealed that strain ASS-1T showed high similarity to Pseudomonas guguanensis CC-G9AT (98...
December 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29239713/leptospira-venezuelensis-sp-nov-a-new-member-of-the-intermediate-group-isolated-from-rodents-cattle-and-humans
#14
Rafael Puche, Ignacio Ferrés, Lizeth Caraballo, Yaritza Rangel, Mathieu Picardeau, Howard Takiff, Gregorio Iraola
Three strains, CLM-U50T, CLM-R50 and IVIC-Bov1, belonging to the genus Leptospira, were isolated in Venezuela from a patient with leptospirosis, a domestic rat (Rattus norvegicus) and a cow (Bos taurus), respectively. The initial characterisation of these strains based on the rrs gene (16S rRNA) suggested their designation as a novel species within the 'intermediates' group of the genus Leptospira. Further phylogenomic characterisation based on single copy core genes was consistent with their separation into a novel species...
December 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29239705/living-in-germany-as-a-kanak-some-thoughts-about-nonbelonging
#15
Tülay Özbek
Kanak is a swear word used by Germans for Turkish migrants. From the beginning of Turkish migration sixty years up to now the meaning of this swear word has changed. The word Kanak transformed from a swear word to a name that is carried now "with proud defiance" by the children and grandchildren of the first-generation migrants. Kanak became a synonym for a new and different "German-ness." Introducing and relating to the concepts of the "internal racial other" of Fahkry Davids, the "large group identity" of Vamık Volkan, and his own conception of hybrid identity development, the author analyzes the impact of such identity transformations on the "migrants" as well as on the "natives" and in particular on the host large group...
December 2017: Psychoanalytic Review
https://www.readbyqxmd.com/read/29239696/compression-garments-and-cerebral-blood-flow-influence-on-cognitive-and-exercise-performance
#16
Brittany A Smale, Joseph M Northey, Disa J Smee, Nathan G Versey, Ben Rattray
This study aimed to describe the effect of compression garments on middle cerebral artery blood flow velocity (MCAv) in relation to cognitive and exercise performance whilst cycling. In a randomised-controlled-cross-over design, 15 well-trained male cyclists were recruited to participate in three identical trials wearing loose fitting shorts (control), low-grade, or medium-grade compression garments. The protocol involved four 8 min increments of cycling at 30%, 50%, 70%, and 85% maximal power output and a 4 km time-trial...
December 14, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/29239666/highly-selective-and-sensitive-measurement-of-active-forms-of-fgf21-using-novel-immunocapture-enrichment-with-lc-ms-ms
#17
Yue Zhao, Guowen Liu, Suk Kwok, Barry R Jones, Jane Liu, David Marchisin, Philip E Joyce, Jon Peterson, Jim X Shen
AIM: Recombinant FGF21 analogs are under wide ranging investigations as a potential therapeutic agent for Type 2 diabetes, as well as other metabolic disorders. The endogenous FGF21 is often used as a surrogate pharmacodynamic(PD) biomarker to assess drug efficacy and safety. Results/methodology: Immunocapture was performed using a monoclonal antibody which had been generated to bind to specific domain of native FGF21 as the capture reagent. After immunocapture, enzymatic digestion was performed and a native FGF21-specific tryptic peptide was monitored using LC-MS/MS by selective reaction monitoring...
December 14, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29239642/are-creative-individuals-bad-apples-a-dual-pathway-model-of-unethical-behavior
#18
Sejin Keem, Christina E Shalley, Eugene Kim, Inseong Jeong
Research has been inconsistent in its quest to discover whether dispositional creativity is associated with more or less unethical behavior. Drawing on social cognitive theory, we propose that moral disengagement and moral imagination are 2 parallel mechanisms that encourage or inhibit unethical behavior, and that which of these mediation processes occur depends on moral identity. Study 1, a 3-wave study of a food service organization, shows that employees high on both dispositional creativity and moral identity are less likely to be morally disengaged and behave less unethically...
December 14, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/29239640/bad-behavior-keeps-you-up-at-night-counterproductive-work-behaviors-and-insomnia
#19
Zhenyu Yuan, Christopher M Barnes, Yongjuan Li
Drawing from recent research on counterproductive work behaviors (CWB) and moral self-regulation literature, we examine the intraindividual consequences of engaging in CWB. We posit that CWB represents morally discrediting work behaviors that can lead to moral deficits, create distress for perpetrators and ultimately result in insomnia. Specifically, we hypothesized that on days in which employees engage in CWB, they will tend to experience moral deficits and heightened levels of rumination that undermine their sleep that night...
December 14, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/29239626/maternal-psychological-control-maternal-borderline-personality-disorder-and-adolescent-borderline-features
#20
Rebecca M Mahan, Stephanie B Kors, Meredith L Simmons, Jenny Macfie
Linehan (1993) theorized that the experience of invalidating parenting interacts with emotional vulnerability in the development of borderline personality disorder (BPD). Parental psychological control is a type of invalidating parenting, defined as manipulation by parents of their offspring's psychological and emotional expression and experience (Barber, 1996). In a normative sample of adolescent females, adolescent-reported maternal psychological control was related to maternal borderline symptoms (Zalewski et al...
December 14, 2017: Personality Disorders
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