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https://www.readbyqxmd.com/read/28823097/epitope-mapping-of-histo-blood-group-antigens-bound-to-norovirus-vlps-using-std-nmr-experiments-reveals-fine-details-of-molecular-recognition
#1
Brigitte Fiege, Mila Leuthold, Francisco Parra, Kevin P Dalton, Peter J Meloncelli, Todd L Lowary, Thomas Peters
Attachment of human noroviruses to histo blood group antigens (HBGAs) is thought to be critical for the infection process. Therefore, we have determined binding epitopes of synthetic type 1 to 6 blood group A- and B-tetrasaccharides binding to GII.4 human Norovirus virus like particles (VLPs) using STD NMR experiments. So far, little information is available from crystal structure analysis studies on the interactions of the reducing-end sugars with the protruding domain (P-domain) of the viral coat protein VP1...
August 19, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28823041/age-estimation-based-on-aspartic-acid-racemization-in-dentine-what-about-caries-affected-teeth
#2
Nazan Sirin, Christian Matzenauer, Alexandra Reckert, Stefanie Ritz-Timme
Age estimation based on aspartic acid racemization (AAR) in dentine is one of the most precise methods in adult age. Caries induces protein degradation and may have an impact on the kinetics of AAR in dentine. We systematically examined standardized prepared dentine samples from caries-affected teeth to clarify the question, if caries-affected teeth should not be used for age estimation based on AAR at all, or if the analysis of dentine samples from such teeth may be useful after removal of the caries-affected tissue according to clinical standards...
August 19, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28823028/backbone-resonance-assignments-of-complexes-of-human-voltage-dependent-sodium-channel-nav1-2-iq-motif-peptide-bound-to-apo-calmodulin-and-to-the-c-domain-fragment-of-apo-calmodulin
#3
Ryan Mahling, Adina M Kilpatrick, Madeline A Shea
Human voltage-gated sodium channel NaV1.2 has a single pore-forming α-subunit and two transmembrane β-subunits. Expressed primarily in the brain, NaV1.2 is critical for initiation and propagation of action potentials. Milliseconds after the pore opens, sodium influx is terminated by inactivation processes mediated by regulatory proteins including calmodulin (CaM). Both calcium-free (apo) CaM and calcium-saturated CaM bind tightly to an IQ motif in the C-terminal tail of the α-subunit. Our thermodynamic studies and solution structure (2KXW) of a C-domain fragment of apo (13)C,(15)N- CaM (CaMC) bound to an unlabeled peptide with the sequence of rat NaV1...
August 19, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28822955/studying-the-old-masters-of-nursing-a-critical-student-experience-for-developing-nursing-identity
#4
Jacinta Kelly, Roger Watson, James Watson, Malachi Needham, Laura O Driscoll
In the past professional identity in nursing was inculcated in students alongside institutional pride. A strong sense of professional identity is key to staff retention and recruitment and key to the delivery of quality nursing care. With the wholesale transfer of pre-registration nursing education to the third level sector, however, the reality is that students now divide their affiliations between university and healthcare institutions and professional identity development may be stymied. For this reason, there is need to explore alternative means of developing professional identity...
July 4, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28822928/combined-effects-of-salinity-temperature-and-hypoxia-on-daphnia-magna-metabolism
#5
Elba Garreta-Lara, Bruno Campos, Carlos Barata, Silvia Lacorte, Romà Tauler
Metabolic changes of Daphnia magna pools due different abiotic factors linked to global climate change (salinity, temperature and hypoxia) were investigated using untargeted GC-MS and advanced chemometric strategies using a three factors two-level full factorial experimental design (DoE). Effects of these three factors and identity of the metabolites whose concentrations changed because of them were investigated. The simultaneous analysis of GC-MS data sets using Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) allowed the resolution of the elution and mass spectra profiles of a large number of D...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822884/with-directed-study-before-a-4-day-operating-room-management-course-trust-in-the-content-did-not-change-progressively-during-the-classroom-time
#6
Franklin Dexter, Richard H Epstein, Brenda G Fahy, Lyn M Van Swol
STUDY OBJECTIVE: A 4-day course in operating room (OR) management is sufficient to provide anesthesiologists with the knowledge and problem solving skills needed to participate in projects of the systems-based-practice competency. Anesthesiologists may need to learn fewer topics when the objective is, instead, limited to comprehension of decision-making on the day of surgery, We tested the hypothesis that trust in course content would not increase further after completion of topics related to OR decision-making on the day of surgery...
August 17, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28822827/host-genes-regulate-transcription-of-sperm-introduced-hepatitis-b-virus-genes-in-embryo
#7
Ying Zhong, Dong-Ling Liu, Mohamed Morsi M Ahmed, Peng-Hao Li, Xiao-Ling Zhou, Qing-Dong Xie, Xiao-Qing Xu, Ting-Ting Han, Zhi-Wei Hou, Chen-Yao Zhong, Ji-Hua Huang, Fei Zeng, Tian-Hua Huang
Hepatitis B virus (HBV) can invade the male germline, and sperm-introduced HBV genes could be transcribed in embryo. This study was to explore whether viral gene transcription is regulated by host genes. Embryos were produced by in vitro fertilization of hamster oocytes with human sperm containing the HBV genome. Total RNA extracted from test and control embryos were subjected to SMART-PCR, SSH, microarray hybridization, sequencing and BLAST analysis. Twenty-nine sequences showing significant identity to five human gene families were identified, with CSH2, EIF4G2, PCBD2, PSG4 and TTN selected to represent target genes...
August 16, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28822795/strategies-for-analyzing-bisulfite-sequencing-data
#8
Katarzyna Wreczycka, Alexander Gosdschan, Dilmurat Yusuf, Björn Grüning, Yassen Assenov, Altuna Akalin
DNA methylation is one of the main epigenetic modifications in the eukaryotic genome; it has been shown to play a role in cell-type specific regulation of gene expression, and therefore cell-type identity. Bisulfite sequencing is the gold-standard for measuring methylation over the genomes of interest. Here, we review several techniques used for the analysis of high-throughput bisulfite sequencing. We introduce specialized short-read alignment techniques as well as pre/post-alignment quality check methods to ensure data quality...
August 16, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28822716/contrast-effects-on-speed-perception-for-linear-and-radial-motion
#9
Rebecca A Champion, Paul A Warren
Speed perception is vital for safe activity in the environment. However, considerable evidence suggests that perceived speed changes as a function of stimulus contrast, with some investigators suggesting that this might have meaningful real-world consequences (e.g. driving in fog). In the present study we investigate whether the neural effects of contrast on speed perception occur at the level of local motion processing or more complex global motion configurations. To do this we examine both speed discrimination thresholds and contrast-dependent speed perception for two global motion configurations that have matched local spatio-temporal structure...
August 16, 2017: Vision Research
https://www.readbyqxmd.com/read/28822700/full-length-genome-of-a-novel-genotype-3-hepatitis-e-virus-strain-obtained-from-domestic-pigs-in-japan
#10
Putu Prathiwi Primadharsini, Masao Miyake, Satoshi Kunita, Tsutomu Nishizawa, Masaharu Takahashi, Shigeo Nagashima, Tanggis, Hiroshi Ohnishi, Tominari Kobayashi, Takashi Nishiyama, Suljid Jirintai, Hiroaki Okamoto
Hepatitis E virus (HEV) causes acute or chronic hepatitis in humans and can be transmitted via the fecal-oral route. Pigs are one of the main reservoirs for this infection. Sixty pigs, 4-5 months of age, on a swine herd in Japan had detectable anti-HEV IgG antibodies, and five (8.3%) of them had ongoing infection of genotype 3 HEV. Five HEV strains obtained from the viremic pigs shared 98.8-100% nucleotide identity, and one representative strain (swHE1606845), whose entire genomic sequence was determined in this study, differed by 14...
August 16, 2017: Virus Research
https://www.readbyqxmd.com/read/28822684/cross-reactivity-and-inhibition-myotoxic-effects-induced-by-bothrops-snake-venoms-using-specific-polyclonal-anti-bnsp7-antibodies
#11
Lamartine L Melo, Mirian M Mendes, Lívia M Alves, Thais F Isabel, Sâmela A P B Vieira, Sarah N C Gimenes, Andreimar M Soares, Veridiana M Rodrigues, Luiz F M Izidoro
Polyclonal antibodies raised in Balb-c mice against BnSP-7, a Lys-49 phospholipase A2, were used to measure cross reactivity against other snake venoms. Using ELISA, these antibodies were able to recognize PLA2s isoforms present in venoms of botropic snakes at 1:6400, 1:3200 and 1:100 ratios (w/w). These antibodies highly recognized proteins of low molecular weight (∼14,000) from crude snake venom Bp and Bm by Western Blotting. PLA2 these venoms, by alignment of primary structures demonstrated high identity with BnSP-7 PLA2, especially in the C-terminal region...
August 16, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28821986/comparative-analysis-of-the-effects-of-co2-fractional-laser-and-sonophoresis-on-human-skin-penetration-with-5-aminolevulinic-acid
#12
J H Choi, E J Shin, K H Jeong, M K Shin
Successful delivery of a photosensitizer into the skin is an important factor for effective photodynamic therapy (PDT). The effective method to increase drug penetration within short incubation time overcoming skin barrier have been investigated. This study was performed to analyze and compare the effectiveness of ablative fractional laser (FXL) pretreatment and/or sonophoresis for enhancing the penetration of 5-aminolevulinic acid (ALA) into human skin in vivo. Twenty-four identical 1 × 1 cm(2) treatment areas were mapped on the backs of ten healthy male subjects...
August 19, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28821848/reconfiguration-of-quantum-states-in-formula-see-text-symmetric-quasi-one-dimensional-lattices
#13
Jung-Wan Ryu, Nojoon Myoung, Hee Chul Park
We demonstrate mesoscopic transport through quantum states in quasi-1D lattices maintaining the combination of parity and time-reversal symmetries by controlling energy gain and loss. We investigate the phase diagram of the non-Hermitian system where transitions take place between unbroken and broken [Formula: see text]-symmetric phases via exceptional points. Quantum transport in the lattice is measured only in the unbroken phases in the energy band-but not in the broken phases. The broken phase allows for spontaneous symmetry-broken states where the cross-stitch lattice is separated into two identical single lattices corresponding to conditionally degenerate eigenstates...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821774/pre-coincidence-brain-activity-predicts-the-perceptual-outcome-of-streaming-bouncing-motion-display
#14
Song Zhao, Yajie Wang, Lina Jia, Chengzhi Feng, Yu Liao, Wenfeng Feng
When two identical visual discs move toward each other on a two-dimensional visual display, they can be perceived as either "streaming through" or "bouncing off" each other after their coincidence. Previous studies have observed a strong bias toward the streaming percept. Additionally, the incidence of the bouncing percept in this ambiguous display could be increased by various factors, such as a brief sound at the moment of coincidence and a momentary pause of the two discs. The streaming/bouncing bistable motion phenomenon has been studied intensively since its discovery...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821748/anxiety-related-experience-dependent-white-matter-structural-differences-in-adolescence-a-monozygotic-twin-difference-approach
#15
Nagesh Adluru, Zhan Luo, Carol A Van Hulle, Andrew J Schoen, Richard J Davidson, Andrew L Alexander, H Hill Goldsmith
Anxiety is linked to deficits in structural and functional connectivity between limbic structures and pre-frontal cortices. We employed a monozygotic (MZ) twin difference design to examine the relationship between structural characteristics of the uncinate fasciculus (UF) measured by Diffusion Tensor Imaging (DTI) and anxiety symptoms in a sample of N = 100 monozygotic (genetically identical), adolescent twins. The MZ difference design allowed us focus on environmental factors that vary within twin pairs while controlling for genetic and environmental factors shared by twin pairs...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821745/metabolomics-and-genomics-combine-to-unravel-the-pathway-for-the-presence-of-fragrance-in-rice
#16
Venea Dara Daygon, Mariafe Calingacion, Louise C Forster, James J De Voss, Brett D Schwartz, Ben Ovenden, David E Alonso, Susan R McCouch, Mary J Garson, Melissa A Fitzgerald
Since it was first characterised in 1983, 2-acetyl-1-pyrroline (2AP) has been considered to be the most important aroma compound in rice. In this study, we show four other amine heterocycles: 6-methyl, 5-oxo-2,3,4,5-tetrahydropyridine (6M5OTP), 2-acetylpyrrole, pyrrole and 1-pyrroline, that correlate strongly with the production of 2AP, and are present in consistent proportions in a set of elite aromatic rice varieties from South East Asia and Australia as well as in a collection of recombinant inbred lines (RILs) derived from indica Jasmine-type varieties, Australian long grain varieties (temperate japonica) and Basmati-type rice (Grp V)...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821711/genetic-cargo-and-bacterial-species-set-the-rate-of-vesicle-mediated-horizontal-gene-transfer
#17
Frances Tran, James Q Boedicker
Most bacteria release extracellular vesicles (EVs). Recent studies have found these vesicles are capable of gene delivery, however the consequences of vesicle-mediated transfer on the patterns and rates of gene flow within microbial communities remains unclear. Previous studies have not determined the impact of both the genetic cargo and the donor and recipient species on the rate of vesicle-mediated gene exchange. This report examines the potential for EVs as a mechanism of gene transfer within heterogeneous microbial populations...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821649/effector-invariant-movement-encoding-in-the-human-motor-system
#18
Shlomi Haar, Ilan Dinstein, Ilan Shelef, Opher Donchin
Ipsilateral motor areas of cerebral cortex are active during arm movements and even reliably predict movement direction. Is coding similar during ipsilateral and contralateral movements? If so, is it in extrinsic (world-centered) or intrinsic (joint-configuration) coordinates? We addressed these questions by examining the similarity of multi-voxel fMRI patterns in visuomotor cortical regions during unilateral reaching movements with both arms. The results of three complementary analyses revealed that fMRI response patterns were similar across right and left arm movements to identical targets (extrinsic coordinates) in visual cortices, and across movements with equivalent joint-angles (intrinsic coordinates) in motor cortices...
August 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28821648/bilingual-language-switching-in-the-lab-vs-in-the-wild-the-spatio-temporal-dynamics-of-adaptive-language-control
#19
Esti Blanco-Elorrieta, Liina Pylkkänen
For a bilingual human, every utterance requires a choice about which language to use. This choice is commonly regarded as part of general executive control, engaging prefrontal and anterior cingulate cortices similarly to many types of effortful task-switching. However, while language control within artificial switching paradigms has been heavily studied, the neurobiology of natural switching within socially cued situations has not been characterized. Additionally, although theoretical models address how language control mechanisms adapt to the distinct demands of different interactional contexts, these predictions have not been empirically tested...
August 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28821591/specifying-cell-fate-in-roots-requires-coordinative-lineage-instruction-and-positional-reprogramming
#20
Qiaozhi Yu, Pengxue Li, Nengsong Liang, Hong Wang, Meizhi Xu, Shuang Wu
Tissue organization and pattern formation within a multicellular organism relies on coordinated cell division and cell fate determination. In animals cell fates are mainly determined by a cell lineage dependent mechanism, whereas in plants positional information is thought to be the primary determinant of cell fates (Scheres, 2001; Kidner et al., 2000; Kim et al., 2005; Scheres et al., 2002). However, our understanding of cell fate regulation in plants mostly relies on the histological and anatomical studies on Arabidopsis roots which contain a single layer of each cell type in non-vascular tissues (Scheres et al...
August 18, 2017: Plant Physiology
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