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https://www.readbyqxmd.com/read/29165956/prophylactic-management-of-contrast-induced-acute-kidney-injury-in-high-risk-patients
#1
Diya Nahar
Contrast-induced acute kidney injury (CI-AKI) has been linked to morbidity and mortality, especially in high-risk patients whose kidney function is compromised. Recently, many studies have been conducted to search for more novel, preventative methods of decreasing CI-AKI. Through a detailed analysis of recent studies, this article discusses recommendations for hydration, N-acetylcysteine, and statin therapy in relation to the prophylactic management of CI-AKI in high-risk patients.
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165875/4%C3%AE-hydroxywithanolide-e-selectively-induces-oxidative-dna-damage-for-selective-killing-of-oral-cancer-cells
#2
Jen-Yang Tang, Hurng-Wern Huang, Hui-Ru Wang, Ya-Ching Chan, Jo-Wen Haung, Chih-Wen Shu, Yang-Chang Wu, Hsueh-Wei Chang
Reactive oxygen species (ROS) induction had been previously reported in 4β-hydroxywithanolide (4βHWE)-induced selective killing of oral cancer cells, but the mechanism involving ROS and the DNA damage effect remain unclear. This study explores the role of ROS and oxidative DNA damage of 4βHWE in the selective killing of oral cancer cells. Changes in cell viability, morphology, ROS, DNA double strand break (DSB) signaling (γH2AX foci in immunofluorescence and DSB signaling in western blotting), and oxidative DNA damage (8-oxo-2'deoxyguanosine [8-oxodG]) were detected in 4βHWE-treated oral cancer (Ca9-22) and/or normal (HGF-1) cells...
November 22, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29165357/new-metabolites-of-coumarin-detected-in-human-urine-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry
#3
Letícia Paula Leonart, João Cleverson Gasparetto, Flávia Lada Degaut Pontes, Letícia Bonancio Cerqueira, Thais Martins Guimarães de Francisco, Roberto Pontarolo
Coumarin (1,2-benzopyrone) is a natural compound whose metabolism in humans was established in the 1970s. However, a new metabolite was recently identified in human plasma, indicating that the metabolism of coumarin has not been completely elucidated. To complement the knowledge of its metabolism, a rapid and sensitive method using UPLC-QTOF-MS was developed. A total of 12 metabolites was identified using MetaboLynxTM software, including eight metabolites not previously reported in human urine. The identified biotransformation included hydroxylation, glucuronidation, sulfation, methylation, and conjugation with N-acetylcysteine...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29163689/aurora-kinase-a-inhibitor-tcs7010-demonstrates-pro-apoptotic-effect-through-the-unfolded-protein-response-pathway-in-hct116-colon-cancer-cells
#4
Da Hyun Lee, Chang Gun Kim, Yoongho Lim, Soon Young Shin
Aurora kinase A (AURKA) is essential for regulating mitosis and is frequently amplified in various cancer cell types. However, the effect of AURKA inhibition on the induction of apoptosis remains unclear. In the present study, it was reported that treatment with TCS7010, a specific inhibitor of AURKA, resulted in the accumulation of cells in the sub-G0/G1 phase of the cell cycle and increased the percentage of annexin V-binding cells. The cleavage of caspase-2, caspase-7, and poly(ADP-ribose)polymerase (PARP) significantly increased in a time-dependent manner following TCS7010 treatment...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29157011/reactive-oxygen-species-modulate-itraconazole-induced-apoptosis-via-mitochondrial-disruption-in-candida-albicans
#5
Wonjong Lee, Dong Gun Lee
Itraconazole (ITC), a well-known fungistatic agent, has potent fungicidal activity against Candida albicans. However, its mechanism of fungicidal activity has not been elucidated yet, and we aimed to identify the mechanism of ITC against C. albicans. ITC caused cell shrinkage via potassium leakage though the ion channel. Since shrunken cells could indicate apoptosis, we investigated apoptotic features. Annexin V-FITC and TUNEL assays indicated that fungicidal activity of ITC was involved in apoptosis. Subsequently, we confirmed an intracellular factor that could cause apoptosis...
November 20, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29154978/7-ketocholesterol-induces-ros-mediated-mrna-expression-of-12-lipoxygenase-cyclooxygenase-2-and-pro-inflammatory-cytokines-in-human-mesangial-cells-potential-role-in-diabetic-nephropathy
#6
Yasuhiro Watanabe, Takashi Yamaguchi, Noriko Ishihara, Shoko Nakamura, Sho Tanaka, Rena Oka, Haruki Imamura, Yuta Sato, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Naomi Shimizu, Atsuhito Saiki, Ichiro Tatsuno
7-Ketocholesterol (7-KCHO) is a highly proinflammatory oxysterol and plays an important role in the pathophysiology of diabetic nephropathy (DN). Lipoxygenases (LOXs) and cyclooxygenases (COXs) are also involved in the development of DN. The aim of this study was to clarify the effects of 7-KCHO on mRNA expression of LOXs and COXs as well as pro-inflammatory cytokines in human mesangial cells (HMC). We evaluated cell viability by WST-8 assay and measured mRNA expression by reverse transcription-polymerase chain reaction...
November 15, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29154739/oxidative-stress-induced-inflammatory-responses-and-effects-of-n-acetylcysteine-in-bovine-mammary-alveolar-cells
#7
Hyojin Bae, Chang Hee Jeong, Wei Nee Cheng, Kwonho Hong, Han Geuk Seo, Sung Gu Han
Bovine mastitis, an inflammation of the udder, results in reduced milk production and poor milk quality. Mastitis is usually, but not always, a response to pathogen infection. High milk yield can produce oxidative stress in the mammary tissue. High milk yield is also known to be associated with bovine mastitis. Thus, in the current study, we hypothesised that oxidative stress increases inflammatory responses in bovine mammary cells. To examine the hypothesis, we produced cellular oxidative stress and investigated resulting inflammatory responses in bovine mammary alveolar cells (MAC-T)...
November 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/29148111/being-overweight-or-obese-as-a-risk-factor-for-acute-liver-injury-secondary-to-acute-acetaminophen-overdose
#8
Summon Chomchai, Chulathida Chomchai
PURPOSE: Increased incidences of hepatotoxicity have been observed in obese patients with acute acetaminophen overdose. We evaluate whether the status of being overweight or obese is associated with increase in the development of hepatotoxicity and acute liver injury (ALI) in patients with acute acetaminophen overdose. METHODS: This was a retrospective cohort study comparing the risk of hepatotoxicity and ALI between overweight or obese patients (body mass index [BMI] ≥ 25) and normal BMI patients (BMI ≤ 24...
November 17, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29138589/clinical-characteristics-and-outcome-of-toxicity-from-amanita-mushroom-poisoning
#9
Satariya Trakulsrichai, Charuwan Sriapha, Achara Tongpoo, Umaporn Udomsubpayakul, Sunun Wongvisavakorn, Sahaphume Srisuma, Winai Wananukul
Objective: To describe and analyze the clinical characteristics and outcome of amatoxin poisoning cases. Methods: We performed a retrospective cohort study of amatoxin poisoning cases from Ramathibodi Poison Center Toxic Exposure Surveillance System, from May 2013 to August 2015. Results: There were 30 consultations with a total of 55 poisoning cases. Most cases were male and from the north-east region. Hepatitis, acute kidney injury, jaundice, and coagulopathy accounted for 74%, 46...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29132195/current-evidence-for-the-use-of-n-acetylcysteine-following-liver-resection
#10
REVIEW
Richard Kemp, Jonathan Mole, Dhanny Gomez
BACKGROUND: N-acetylcysteine (NAC) has many uses in medicine; notable in the management of paracetamol toxicity, acute liver failure and liver surgery. The aim of this review was to critically appraise the published literature for the routine use of NAC in liver resection surgery. METHODS: An electronic search was performed of EBSCOhost (Medline and CINAHL database), PubMed and the Cochrane Library for the period 1990-2016. MeSH headings: 'acetyl-cysteine', 'liver resection' and 'hepatectomy' were used to identify all relevant articles published in English...
November 13, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29128613/submicromolar-bisphenol-a-induces-proliferation-and-dna-damage-in-human-hepatocyte-cell-lines-in-vitro-and-in-juvenile-rats-in-vivo
#11
Seoyoung Kim, Gil-Im Mun, Eun Choi, Minjeong Kim, Ji Seong Jeong, Keon Wook Kang, Sunha Jee, Kyung-Min Lim, Yun-Sil Lee
An association between bisphenol A (BPA) exposure and hepatic tumors was suggested, but the employment of high-dose levels raises questions about its relevance to human health. Here, we demonstrate that submicromolar concentrations of BPA induce the proliferation and DNA damage in human hepatocyte cell lines. In HepG2 and NKNT-3, undifferentiated and differentiated hepatocyte cell lines, respectively, submicromolar BPA concentrations promoted the cell proliferation, as indicated by enhanced DNA synthesis and elevated expression of cell-cycle proteins...
November 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29125538/cigarette-smoke-regulates-the-competitive-interactions-between-nrf2-and-bach1-for-heme-oxygenase-1-induction
#12
Wen-Hsin Chang, Philip Thai, Jihao Xu, David C Yang, Reen Wu, Ching-Hsien Chen
Cigarette smoke has been shown to trigger aberrant signaling pathways and pathophysiological processes; however, the regulatory mechanisms underlying smoke-induced gene expression remain to be established. Herein, we observed that two smoke-responsive genes, HO-1 and CYP1A1, are robustly induced upon smoke by different mechanisms in human bronchial epithelia. CYP1A1 is mediated by aryl hydrocarbon receptor signaling, while induction of HO-1 is regulated by oxidative stress, and suppressed by N-acetylcysteine treatment...
November 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29125225/baicalein-reduces-oxidative-stress-in-cho-cell-cultures-and-improves-recombinant-antibody-productivity
#13
Tae Kwang Ha, Anders Holmgaard Hansen, Stefan Kol, Helene Faustrup Kildegaard, Gyun Min Lee
Oxidative stress that naturally accumulates in the endoplasmic reticulum (ER) as a result of mitochondrial energy metabolism and protein synthesis can disturb the ER function. Because ER has a responsibility on the protein synthesis and quality control of the secreted proteins, ER homeostasis has to be well maintained. When H2O2, an oxidative stress inducer, was added to recombinant Chinese hamster ovary (rCHO) cell cultures, it reduced cell growth, monoclonal antibody (mAb) production, and galactosylated form of mAb in a dose-dependent manner...
November 10, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29123322/hypoxia-induced-reactive-oxygen-species-mediate-n-cadherin-and-serpine1-expression-egfr-signalling-and-motility-in-mda-mb-468-breast-cancer-cells
#14
Iman Azimi, Rosalie M Petersen, Erik W Thompson, Sarah J Roberts-Thomson, Gregory R Monteith
One of the hallmarks of the tumour microenvironment is hypoxia resulting from increased oxygen consumption by proliferative cancer cells and altered vasculature. Hypoxic tension initiates various cellular signals and can drive epithelial to mesenchymal transition (EMT), a process important in cancer progression. In this study, using the antioxidant N-acetylcysteine (NAC), we show that hypoxia-induced reactive oxygen species (ROS) in MDA-MB-468 breast cancer cells, selectively regulate hypoxia-induced increases in N-cadherin and SERPINE1, two proteins involved in cell adhesion...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119993/a-study-of-the-reactivity-of-s-vi-f-containing-warheads-with-nucleophilic-amino-acid-side-chains-under-physiological-conditions
#15
H Mukherjee, J Debreczeni, J Breed, S Tentarelli, B Aquila, J E Dowling, A Whitty, N P Grimster
Sulfonyl fluorides (SFs) have recently emerged as a promising warhead for the targeted covalent modification of proteins. Despite numerous examples of the successful deployment of SFs as covalent probe compounds, a detailed exploration of the factors influencing the stability and reactivity of SFs has not yet appeared. In this work we present an extensive study on the influence of steric and electronic factors on the reactivity and stability of the SF and related S(VI)-F groups. While SFs react rapidly with N-acetylcysteine, the resulting adducts were found to be unstable, rendering SFs inappropriate for the durable covalent inhibition of cysteine residues...
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29119850/dopamine-induces-platelet-production-from-megakaryocytes-via-oxidative-stress-mediated-signaling-pathways
#16
Shilei Chen, Mengjia Hu, Mingqiang Shen, Yang Xu, Cheng Wang, Xinmiao Wang, Fengju Li, Dongfeng Zeng, Fang Chen, Gaomei Zhao, Mo Chen, Fengchao Wang, Tianmin Cheng, Yongping Su, Jinghong Zhao, Song Wang, Junping Wang
Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet its function in thrombopoiesis remains poorly understood. This study shows that DA stimulation can directly induce platelet production from megakaryocytes (MKs) in the final stages of thrombopoiesis via a reactive oxygen species (ROS)-dependent pathway. The mechanism was suggested by the results that DA treatment could significantly elevate the ROS levels in MKs, and time-dependently activate oxidative stress-mediated signaling, including p38 mitogen-activated protein kinase, c-Jun NH2-terminal kinase, and caspase-3 signaling pathways, while the antioxidants N-acetylcysteine and L-glutathione could effectively inhibit the activation of these signaling pathways, as well as the ROS increase and platelet production triggered by DA...
November 9, 2017: Platelets
https://www.readbyqxmd.com/read/29117515/metformin-and-epothilone-a-treatment-up-regulate-pro-apoptotic-parp-1-casp-3-and-h2ax-genes-and-decrease-of-akt-kinase-level-to-control-cell-death-of-human-hepatocellular-carcinoma-and-ovary-adenocarcinoma-cells
#17
Aneta Rogalska, Barbara Bukowska, Agnieszka Marczak
High mortality rates in ovarian and liver cancer are largely a result of resistance to currently used chemotherapy. Here, we investigated genotoxic and pro-oxidant effects of metformin (MET) and epothilone A (A) in combination with respect to apoptosis in HepG2 and SKOV-3 cancer cells. Reactive oxygen species (ROS) was studied using 2',7'-dichlorodihydrofluoresein diacetate, and samples were analyzed for the presence and absence of the N-acetylcysteine (NAC). Expression of genes involved in programmed cell death, oxidative and alkylating DNA damage was measured...
November 5, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29115506/angiotensin-ii-induces-monocyte-chemoattractant-protein%C3%A2-1-expression-by-increasing-reactive-oxygen-species%C3%A2-mediated-activation-of-the-nuclear-factor%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-osteoblasts
#18
Changyao Wang, Cailong Zhang, Feng Zhou, Lei Gao, Yingzhen Wang, Chunsheng Wang, Yongtao Zhang
The present study investigated the effect of angiotensin II (Ang II) on monocyte chemoattractant protein‑1 (MCP‑1) expression and the underlying mechanism in osteoblasts. MCP‑1 expression levels were analyzed by ELISA and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Ang II type 1 receptor (AT1R) expression levels was examined by RT‑qPCR, western blotting and immunostaining. In addition, the nuclear factor (NF)‑κB signaling pathway was investigated via western blot analysis...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115375/persistent-stat5-mediated-ros-production-and-involvement-of-aberrant-p53-apoptotic-signaling-in-the-resistance-of-chronic-myeloid-leukemia-to-imatinib
#19
Yanhong Cheng, Yingchan Hao, Aimei Zhang, Chaojie Hu, Xiaoxiao Jiang, Quan Wu, Xiucai Xu
The persistent activation of signal transducer and activator of transcription 5 (STAT5) may principally be attributed to breakpoint cluster region (BCR)-Abelson murine leukemia viral oncogene homolog 1 (ABL1), and have multi-faceted effects in the development of chronic myeloid leukemia (CML). The p53 protein network regulates important mechanisms in DNA damage repair, cell cycle regulation/checkpoints, and cell senescence and apoptosis, as demonstrated by its ability to positively regulate the expression of various pro-apoptotic genes, including B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X protein (Bax)...
October 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29115169/protective-effect-of-captopril-against-diazinon-induced-nephrotoxicity-and-neurotoxicity-via-inhibition-of-ros-no-pathway
#20
Milad Vahidirad, Milad Arab-Nozari, Hamidreza Mohammadi, Ehsan Zamani, Fatemeh Shaki
Diazinon (Dz) is a widely used insecticide. It can induce nephrotoxicity and neurotoxicity via oxidative stress. Captopril, an angiotensin-converting enzyme inhibitor, is known for its antioxidant properties. In this study, we used captopril for ameliorating of Dz-induced kidney and brain toxicity in rats. Animals were divided into five groups as follows: negative control (olive oil), Dz (150 mg kg(-1)), captopril (60 and 100 mg kg(-1)) and positive control (N-acetylcysteine 200 mg kg(-1)) were injected intraperitoneally 30 min before Dz...
November 8, 2017: Drug and Chemical Toxicology
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