keyword
MENU ▼
Read by QxMD icon Read
search

saccharin

keyword
https://www.readbyqxmd.com/read/28106041/glutamatergic-projections-from-the-entorhinal-cortex-to-dorsal-dentate-gyrus-mediate-context-induced-reinstatement-of-heroin-seeking
#1
Feifei Ge, Na Wang, Cailian Cui, Yijing Li, Yan Liu, Yaoying Ma, Shuli Liu, Haolin Zhang, Xiaowei Sun
Re-exposure to the context associated with heroin intake provokes relapse to drug taking after abstinence. The dorsal dentate gyrus (dDG) and entorhinal cortex (EC) have been implicated in contextual memory processing, but the underlying circuit mechanisms in context-induced relapse remains poorly understood. In this study, using a self-administration rat model, we found that activation and synaptic transmission of glutamatergic projections from the EC to the upper blade of dentate gyrus (dDGub) were significantly enhanced during context-induced reinstatement of heroin seeking...
January 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28101344/evaluation-of-pharmacological-relaxation-effect-of-the-natural-product-naringin-on-in-vitro-cultured-airway-smooth-muscle-cells-and-in-vivo-ovalbumin-induced-asthma-balb-c-mice
#2
Yue Wang, Yun Lu, Mingzhi Luo, Xiaohao Shi, Yan Pan, Huilong Zeng, Linhong Deng
Asthma has become a common chronic respiratory disease worldwide and its prevalence is predicted to continue increasing in the next decade, particularly in developing countries. A key component in asthma therapy is to alleviate the excessive bronchial airway narrowing ultimately due to airway smooth muscle contraction, which is often facilitated by a smooth muscle relaxant, such as the β2-adrenergic agonists. Recently, bitter taste receptor (TAS2R) agonists, including saccharin and chloroquine, have been found to potently relax the airway smooth muscle cells (ASMCs) via intracellular Ca(2+) signaling...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28095308/lithium-induced-malaise-does-not-interfere-with-adaptation-of-the-hypothalamic-pituitary-adrenal-axis-to-stress
#3
Maria Sanchís-Ollé, Juan Antonio Ortega-Sánchez, Xavier Belda, Humberto Gagliano, Roser Nadal, Antonio Armario
We have recently demonstrated that adaptation of the hypothalamic-pituitary-adrenal (HPA) axis to repeated exposure to a stressor does not follow the rules of habituation and can be fully expressed after a single experience with severe stressors. In the present work we tested the hypothesis that adaptation could be impaired if animals experience malaise during initial exposure to the stressor. To this end, animals were allowed to drink saccharin for 30min before being exposed for 3h to immobilization on boards (IMO), a severe stressor; then they were given either saline or lithium ip after the first hour of IMO...
January 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28089663/phase-dependent-activity-of-neurons-in-the-rostral-part-of-the-thalamic-reticular-nucleus-with-saccharin-intake-in-a-cue-guided-lever-manipulation-task
#4
Ryuhei Aoki, Risako Kato, Satoshi Fujita, Jun Shimada, Noriaki Koshikawa, Masayuki Kobayashi
Neurons in the rostral part of the thalamic reticular nucleus (rTRN) receive somatosensory and motor information and regulate neural activities of the thalamic nuclei. Previous studies showed that when activity in visual TRN neurons is suppressed prior to the visual stimuli in a visual detection task, the performance of the task improves. However, little is known about such changes in the rTRN preceding certain events. In the present study, we performed unit recordings in the rTRN in alert rats during a cue-guided lever-manipulation task in which saccharin was provided as a reward...
January 12, 2017: Brain Research
https://www.readbyqxmd.com/read/28071796/influence-of-package-visual-cues-of-sweeteners-on-the-sensory-emotional-profiles-of-their-products
#5
Wisdom Wardy, Pitchayapat Chonpracha, Napapan Chokumnoyporn, Sujinda Sriwattana, Witoon Prinyawiwatkul, Wannita Jirangrat
Substantial evidence suggests influence of color, physical state, and other extrinsic features on consumer perception and acceptability of food products. In this study, 560 subjects evaluated liking and emotional responses associated with 5 sweeteners (sucralose, stevia, saccharin, aspartame, and sucrose) under 2 eliciting conditions: control (brand name only) and informed (brand name/packet image), to assess impact of the packet color. For a given condition, 5 identical tea samples each labeled with a sweetener type were rated for sweetness and overall liking (9-point) and emotions (5-point)...
January 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28040488/systemic-administration-of-anorexic-gut-peptide-hormones-impairs-hedonic-driven-sucrose-consumption-in-mice
#6
Erina Yamaguchi, Yasunobu Yasoshima, Tsuyoshi Shimura
A number of reports suggest that gut hormones such as cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and peptide YY(3-36) (PYY3-36), which are released postprandially, suppress homeostatic food intake and result in satiety and the termination of feeding. However, it remains unclear whether these peptide hormones also suppress non-homeostatic consumption of palatable foods or fluids. To examine whether gut hormones reduce hedonically motivated sugar consumption, we assessed the effects of intraperitoneal administration of these gut hormones on the consumption of a highly palatable sucrose solution, using a mouse model we previously established for binge-like sucrose overconsumption (Yasoshima and Shimura, 2015)...
December 28, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28035644/dft-and-tddft-investigation-of-the-schiff-base-formed-by-tacrine-and-saccharin
#7
Nursel Acar, Cenk Selçuki, Emine Coşkun
Schiff bases have many chemical and biological applications in medicine and pharmaceuticals due to the presence of an imine group (-C=N-). These bases are used in many different fields of technology, and in photochemistry because of their photochromic properties. Here, the structural and electronic properties of the Schiff base formed by tacrine and saccharin (TacSac) were explored using density functional theory with the B3LYP, M06-2X, M06L, and ωB97XD functionals in combination with the 6-311++G(d,p) basis set...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28027980/assessment-of-the-carcinogenic-potential-of-high-intense-sweeteners-through-the-test-for-detection-of-epithelial-tumor-clones-warts-in-drosophila-melanogaster
#8
Mirley Alves Vasconcelos, Priscila Capelari Orsolin, Rosiane Gomes Silva-Oliveira, Júlio César Nepomuceno, Mário Antônio Spanó
High intensity-sweeteners (HIS) are natural or synthetic substances, sweeter than sugar, providing sweetness without calories. Sweeteners are mainly used as an aid in losing weight, preventing obesity and controlling blood sugar levels for diabetics. The objective of this study was to evaluate the carcinogenic potential of the sweeteners aspartame, sucralose, sodium saccharin and steviol glycoside, using the test for detection of epithelial tumor clones in Drosophila melanogaster. Larvae of 72 ± 4h, obtained from wts/TM3 female mated with mwh/mwh males, were treated for approximately 48h with different concentrations of aspartame (0...
December 24, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28025002/sulfonamide-inhibition-profile-of-the-%C3%AE-carbonic-anhydrase-identified-in-the-genome-of-the-pathogenic-bacterium-burkholderia-pseudomallei-the-etiological-agent-responsible-of-melioidosis
#9
Sonia Del Prete, Daniela Vullo, Pietro Di Fonzo, Sameh M Osman, Zeid AlOthman, William A Donald, Claudiu T Supuran, Clemente Capasso
A new γ-carbonic anhydrase (CA, EC 4.1.1.1) was cloned and characterized kinetically in the genome of the bacterial pathogen Burkholderia pseudomallei, the etiological agent of melioidosis, an endemic disease of tropical and sub-tropical regions of the world. The catalytic activity of this new enzyme, BpsCAγ, is significant with a kcat of 5.3×10(5)s(-1) and kcat/Km of 2.5×10(7)M(-1)×s(-1) for the physiologic CO2 hydration reaction. The inhibition constant value for this enzyme for 39 sulfonamide inhibitors was obtained...
December 12, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28018190/disruption-of-the-glutamate-glutamine-cycle-involving-astrocytes-in-an-animal-model-of-depression-for-males-and-females
#10
Virginie Rappeneau, Amanda Blaker, Jeff R Petro, Bryan K Yamamoto, Akiko Shimamoto
Background: Women are twice as likely as men to develop major depression. The brain mechanisms underlying this sex disparity are not clear. Disruption of the glutamate-glutamine cycle has been implicated in psychiatric disturbances. This study identifies sex-based impairments in the glutamate-glutamine cycle involving astrocytes using an animal model of depression. Methods: Male and female adult Long-Evans rats were exposed to chronic social defeat stress (CSDS) for 21 days, using a modified resident-intruder paradigm...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28008434/carbodiimide-insertion-into-sulfonimides-one-step-route-to-azepine-derivatives-via-a-two-atom-saccharin-ring-expansion
#11
Davin Tan, Tomislav Friščić
A previously unknown insertion of carbodiimides into sulfonimides enables the first one-step, two-atom expansion of the saccharin 5-membered ring into a 7-membered benzo[1,2,4]thiadiazepine, and a two-atom chain extension of a non-cyclic sulfonimide. This reaction is enhanced by copper salts, which allow it to be conducted mechanochemically, in a solvent-free manner.
December 23, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27986290/pressurised-liquid-extraction-and-liquid-chromatography-high-resolution-mass-spectrometry-to-determine-high-intensity-sweeteners-in-fish-samples
#12
Mireia Núñez, Francesc Borrull, Eva Pocurull, Núria Fontanals
An analytical method based on pressurised liquid extraction (PLE) followed by liquid chromatography-high resolution mass spectrometry (Orbitrap) was developed for the simultaneous determination of ten high-intensity sweeteners in fish samples. As the method was developed, the different PLE parameters were optimised and different clean-up strategies were evaluated, of which in-cell clean-up using alumina and on-cell clean-up with hexane were the most effective. PLE recoveries were between 43% and 94%. The method quantification limits were between 12...
January 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27984436/the-effects-of-short-and-long-term-exposure-to-hyperbaric-oxygen-on-nasal-mucociliary-clearance
#13
Sinan Uluyol, Levent Demir, Saffet Kilicaslan
The aim of this study is to assess the effects of short- and long-term exposure to hyperbaric oxygen (HBO) on nasal mucociliary clearance (MCC). This study included 47 consecutive nondiabetic patients treated with hyperbaric oxygen therapy (HBOT). Participants were divided into 2 groups according to the taken number of HBOT sessions. Nineteen patients who received <11 HBOT sessions comprised short-term HBOT group, 28 patients who received more than 15 sessions comprised the long-term HBOT group. Mucociliary clearance was measured using a saccharin clearance test, which was performed 3 times on patients: prior to, at completion of, and 6 months after HBOT...
December 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27984199/midazolam-impairs-the-retrieval-of-conditioned-taste-aversion-via-opioidergic-transmission-in-mice
#14
Yasunobu Yasoshima, Tsuyoshi Shimura
Midazolam is a benzodiazepine agonist that affects the acquisition, retention, and retrieval of malaise-induced conditioned taste aversion (CTA) in rats. Our previous study suggested that the palatability-enhancing rather than amnesic effects of midazolam were responsible for impaired retrieval of conditioned aversion to palatable conditioned stimuli (CSs). However, it remains unclear whether this effect is opioid-dependent. In the present study, we examined the involvement of opioid signaling with the ability of peripheral midazolam administration to transiently impair CTA retrieval in mice...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27979712/simultaneous-screening-and-detection-of-pharmaceutical-co-crystals-by-the-one-step-dsc-ftir-microspectroscopic-technique
#15
REVIEW
Shan-Yang Lin
Various methods and analytical techniques for the preparation and identification of pharmaceutical co-crystals have been applied, but these operations require considerable time for the screening and preparation of co-crystals. In this review, a powerful method that combines Fourier-transform infrared (FTIR) microspectroscopy with thermal analysis is introduced. This unique one-step real-time differential scanning calorimetry (DSC)-FTIR microspectroscopic approach has been successfully applied to simultaneously and directly screen and detect pharmaceutical co-crystal formation in systems such as indomethacin-saccharin, indomethacin-nicotinamide, carbamazepine-glutaric-acid, metaxalone-succinic-acid and piroxicam-saccharin...
December 12, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27966358/exploring-the-photophysical-and-photochemical-properties-of-n-thioalkyl-saccharins-as-an-alternative-route-to-the-synthesis-of-tricyclic-sultams
#16
Willber D Castro-Godoy, Gabriela Oksdath-Mansilla, Juan E Argüello, Alicia B Peñéñory
Photocyclization of N-(thioalkyl)-saccharin was carried out to obtain different polycyclic sultams in good yields. These photoreactions were efficient under inert atmosphere and acetone triplet-sensitized conditions indicating that the triplet excited state is directly involved in the formation of annulated products. The presence of molecular oxygen changes product distribution, and only photo-oxygenation products (sulfoxides and sulfones) were found. This result is especially valuable since, by simple changing from nitrogen- to oxygen-saturated solvent conditions, the reaction outcome can be tuned from cyclized to sulfur oxidation products...
December 23, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27922639/mesolimbic-leptin-signaling-negatively-regulates-cocaine-conditioned-reward
#17
M Shen, C Jiang, P Liu, F Wang, L Ma
The regulatory mechanisms underlying the response to addictive drugs are complex, and increasing evidence indicates that there is a role for appetite-regulating pathways in substance abuse. Leptin, an important adipose hormone that regulates energy balance and appetite, exerts its physiological functions via leptin receptors. However, the role of leptin signaling in regulating the response to cocaine remains unclear. Here we examined the potential role of leptin signaling in cocaine reward using a conditioned place preference (CPP) procedure...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27917116/preliminary-evidence-of-apathetic-like-behavior-in-aged-vesicular-monoamine-transporter-2-deficient-mice
#18
Aron Baumann, Carlos G Moreira, Marta M Morawska, Sophie Masneuf, Christian R Baumann, Daniela Noain
Apathy is considered to be a core feature of Parkinson's disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and current treatment approaches are unspecific and proved to be only partially effective. In animal models, apathy has been sub-optimally modeled, mostly by means of pharmacological and stress-induced methods, whereby concomitant depressive-like symptoms could not be ruled out...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27888019/ifenprodil-infusion-in-agranular-insular-cortex-alters-social-behavior-and-vocalizations-in-rats-exposed-to-moderate-levels-of-ethanol-during-prenatal-development
#19
Clark W Bird, Daniel Barto, Christy M Magcalas, Carlos I Rodriguez, Tia Donaldson, Suzy Davies, Daniel D Savage, Derek A Hamilton
Moderate exposure to alcohol during development leads to subtle neurobiological and behavioral effects classified under the umbrella term fetal alcohol spectrum disorders (FASDs). Alterations in social behaviors are a frequently observed consequence of maternal drinking, as children with FASDs display inappropriate aggressive behaviors and altered responses to social cues. Rodent models of FASDs mimic the behavioral alterations seen in humans, with rats exposed to ethanol during development displaying increased aggressive behaviors, decreased social investigation, and altered play behavior...
March 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27883962/maternal-care-and-affective-behavior-in-female-offspring-implication-of-the-neurosteroid-gabaergic-system
#20
Amanda P Borrow, Nicole M Cameron
In female rats, the proestrus phase of the estrous cycle is associated with decreased levels of anxiety-like and depressive-like behavior relative to the metestrus phase. Progesterone likely modulate these behaviors, in part through the influence of its metabolite, allopregnanolone (THP) on hippocampal GABAAR subunit expression. As natural variations in maternal care have been found to influence both progesterone levels at proestrus and anxiety-like behavior in female offspring, we sought to investigate the importance of maternal care and the estrous cycle on affective behavior in female rats that had received Low or High levels of licking/grooming (LG) during early life...
November 5, 2016: Psychoneuroendocrinology
keyword
keyword
33530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"