keyword
MENU ▼
Read by QxMD icon Read
search

saccharin

keyword
https://www.readbyqxmd.com/read/28334357/sweetener-intake-by-rats-selectively-bred-for-differential-saccharin-intake-sucralose-stevia-and-acesulfame-potassium
#1
Nancy K Dess, Kiana Dobson, Brandon T Roberts, Clinton D Chapman
Behavioral responses to sweeteners have been used to study the evolution, mechanisms, and functions of taste. Occidental low and high saccharin consuming rats (respectively, LoS and HiS) have been selectively outbred on the basis of saccharin intake and are a valuable tool for studying variation among individuals in sweetener intake and its correlates. Relative to HiS rats, LoS rats consume smaller amounts of all nutritive and nonnutritive sweeteners tested to date, except aspartame. The lines also differ in intake of the commercial product Splenda; the roles of sucralose and saccharides in the difference are unclear...
March 15, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28334211/effect-of-sweeteners-on-the-survival-of-solenopsis-invicta-hymenoptera-formicidae
#2
Xiaoqiang Zhang, Siqi Chen, Zhiqiang Li, Yijuan Xu
The red imported fire ant, Solenopsis invicta Buren, is a serious agricultural, ecological, and public health pest in its invaded range. Chemical insecticides have been widely used for the prevention and control of this notorious pest. To search for novel, cost-effective, and environmentally friendly materials for fire ant control, we tested various sweeteners for their toxicity to S. invicta. The S. invicta that were fed erythritol, aspartame, and saccharin exhibited significantly higher mortality rates than those fed other sweeteners...
March 15, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28333118/synthesis-of-novel-saccharin-derivatives
#3
Gregory M Rankin, Sally-Ann Poulsen
The synthesis of saccharin (1,2-benzisothiazol-3-one-1,1-dioxide) derivatives substituted on the benzene ring has seen limited development despite the longevity of this compound's use as an artificial sweetener. This type of saccharin derivative would however present attractive properties for the development of new bioactive, drug-like small molecule compounds. Here we report the derivatisation of the benzene ring of saccharin using Cu(I)-catalyzed azide alkyne cycloaddition (CuAAC) to synthesise a diverse library of novel saccharin-1,2,3-triazole conjugates...
March 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28325622/the-effect-of-different-nasal-irrigation-solutions-following-septoplasty-and-concha-radiofrequency-a-prospective-randomized-study
#4
Hanifi Kurtaran, K Serife Ugur, Ceyda Sel Yilmaz, Mesut Kaya, Alper Yuksel, Nebil Ark, Mehmet Gunduz
INTRODUCTION: Nasal irrigation solutions are widely used following endonasal surgery. These irrigation solutions remove infective debris and crusts, reducing the probability of synechia formation, and accelerate mucosal healing. OBJECTIVE: The aim of the present study was to compare the effects of nasal irrigation solutions with different contents following septoplasty and concha radiofrequency. METHODS: The present study was a prospective, randomized, controlled simple blind study of 120 patients who underwent septoplasty and bilateral concha radiofrequency...
February 22, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28323090/c-fos-activity-in-the-insular-cortex-nucleus-accumbens-and-basolateral-amygdala-following-the-intraperitoneal-injection-of-saccharin-and-lithium-chloride
#5
Alberto Soto, Patricia Gasalla, Azucena Begega, Matías López
The present study examined c-Fos expression in selected brain areas consequent to intraperitoneal (IP) administration of saccharin and lithium chloride. Rats were tested for aversion to the saccharin as measured by flavor consumption and orofacial reactions in the taste reactivity (TR) test. It was found that intraperitoneal conditioning resulted in the reduction in voluntary consumption but not in the production of aversive orofacial responses to the saccharin. The immunohistochemistry quantification revealed increased c-Fos activity in the insular cortex, the shell and core regions of the nucleus accumbens, and the basolateral nucleus of the amygdala...
March 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28322866/decreased-anxiety-voluntary-ethanol-intake-and-ethanol-induced-cpp-acquisition-following-activation-of-the-metabotropic-glutamate-receptor-8-mglur8
#6
Amine Bahi
Metabotropic glutamate receptors (mGluRs) are important modulators of excitatory neurotransmission, and have been implicated in addiction to alcohol and anxiety-related behaviors. However, the behavioral consequence and contribution of individual subtypes are not known yet. This study determined the effects of mGluR8 activation on anxiety-like behavior, voluntary ethanol intake and ethanol-induced conditioned reward. To this aim, anxiety and spontaneous behavior were measured in C57BL/6J mice using the elevated plus maze (EPM), open field (OF) and light-dark box (LDB) tests after systemic injection of the selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine ((S)-3,4-DCPG)...
March 17, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28303373/viral-mediated-overexpression-of-the-myelin-transcription-factor-1-myt1-in-the-dentate-gyrus-attenuates-anxiety-and-ethanol-related-behaviors-in-rats
#7
Amine Bahi, Jean-Luc Dreyer
RATIONALE: Myelin Transcription Factor 1 (MyT1), a member of the Zinc Finger gene family, plays a fundamental role in the nervous system. Recent research has suggested that this transcription factor is associated with the pathophysiology of psychiatric disorders including addiction, schizophrenia, and depression. However, the role of MyT1 in anxiety- and ethanol-related behaviors is still unknown. OBJECTIVES: We evaluated the effects of lentiviral-mediated overexpression of MyT1 in the dentate gyrus (DG) on anxiety- and ethanol-related behaviors in rats...
March 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28284644/suitability-of-pharmaceuticals-and-personal-care-products-ppcps-and-artificial-sweeteners-ass-as-wastewater-indicators-in-the-pearl-river-delta-south-china
#8
Yuan-Yuan Yang, Wang-Rong Liu, You-Sheng Liu, Jian-Liang Zhao, Qian-Qian Zhang, Min Zhang, Jin-Na Zhang, Yu-Xia Jiang, Li-Juan Zhang, Guang-Guo Ying
Wastewater indicator is a useful tool for evaluating the wastewater impact on natural water, but there is little information about the suitability of wastewater indicators for different regions. This study aimed to select suitable wastewater indicators in the Pearl River Delta region, south China by screening a range of wastewater related organic compounds. The screening campaign was carried out by investigating the occurrence and removal efficiencies of 93 pharmaceuticals and personal care products (PPCPs) and 5 artificial sweeteners (ASs) in nine wastewater treatment plants (WWTPs) located in the region, and the occurrence of these target compounds in the contaminated and clean surface water of the Pearl River...
March 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28277180/simultaneous-determination-of-sodium-saccharin-aspartame-acesulfame-k-and-sucralose-in-food-consumed-in-korea-using-high-performance-liquid-chromatography-and-evaporative-light-scattering-detection
#9
Youngsun Lee, Byungkyung Do, Gunyoung Lee, Ho Soo Lim, Sang Soon Yun, Hoonjeong Kwon
Four artificial sweeteners, i.e., sodium saccharin, aspartame, acesulfame-K and sucralose, are permitted for use in Korea, and recent regulatory changes have expanded the number of food categories in which they may be used. Four artificial sweeteners were determined simultaneously in more than 900 food items from 30 food categories that are commercially available in Korean markets, including both domestic and imported products, using high-performance liquid chromatography and evaporative light-scattering detection (ELSD)...
February 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28274821/the-galanin-3-receptor-antagonist-snap-37889-suppresses-alcohol-drinking-and-morphine-self-administration-in-mice
#10
Karlene J Scheller, Spencer J Williams, Andrew J Lawrence, Elvan Djouma
The neuropeptide, galanin, is widely expressed in the central and peripheral nervous systems and is involved in a range of different functions including nociception, neurogenesis, hormone release, reproduction, cognitive function and appetite. Given the overlap between galanin expression and reward circuitry in the brain, galanin has been targeted for alcohol use disorder (AUD) and opioid dependency. Furthermore, the galanin-3 receptor (GAL3) specifically regulates emotional states and plays a role in motivation, reward and drug-seeking behaviour...
March 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28263712/synergistic-blockade-of-alcohol-escalation-drinking-in-mice-by-a-combination-of-novel-kappa-opioid-receptor-agonist-mesyl-salvinorin-b-and-naltrexone
#11
Yan Zhou, Rachel Saylor Cowley, Konrad Ben, Thomas E Prisinzano, Mary Jeanne Kreek
Mesyl Salvinorin B (MSB) is a potent selective kappa opioid receptor (KOP-r) agonist that has potential for development as an anti-psychostimulant agent with fewer side-effects (e.g., sedation, depression and dysphoria) than classic KOP-r agonists. However, no such study has been done on alcohol. We investigated whether MSB alone or in combination with naltrexone (mu-opioid receptor antagonist) altered voluntary alcohol drinking in both male and female mice. Mice, subjected to 3 weeks of chronic escalation drinking (CED) in a two-bottle choice paradigm with 24-h access every other day, developed rapid escalation of alcohol intake and high preference...
March 2, 2017: Brain Research
https://www.readbyqxmd.com/read/28251932/inhibition-of-sweet-chemosensory-receptors-alters-insulin-responses-during-glucose-ingestion-in-healthy-adults-a-randomized-crossover-interventional-study
#12
Elnaz Karimian Azari, Kathleen R Smith, Fanchao Yi, Timothy F Osborne, Roberto Bizzotto, Andrea Mari, Richard E Pratley, George A Kyriazis
Background: Glucose is a natural ligand for sweet taste receptors (STRs) that are expressed on the tongue and in the gastrointestinal tract. Whether STRs directly contribute to the regulation of glucose homeostasis in response to glucose ingestion is unclear.Objective: We sought to determine the metabolic effects of the pharmacologic inhibition of STRs in response to an oral glucose load in healthy lean participants.Design: Ten healthy lean participants with a body mass index (in kg/m(2)) of 22.4 ± 0.8 were subjected to an oral-glucose-tolerance test (OGTT) on 4 separate days with the use of a randomized crossover design...
March 1, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28239574/do-nasal-surgeries-affect-mucociliary-clearance
#13
Rajeshwary Aroor, Zainab Sunu Ali, K S Gangadhara Somayaji
The study was conducted to assess the impact of different nasal surgeries on the nasal mucociliary clearance mechanism. Mucociliary function of the nasal mucosa of patients who were undergoing various nasal surgeries was assessed by the Saccharin test by placing 5 mg saccharin granule on the anterior end of the inferior turbinate 1 day prior to the surgery. The time required for the test subject to experience a sweet taste was measured in minutes. Post-operatively the test was repeated 6 weeks after the surgery and the test times were compared...
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239405/long-term-intake-of-saccharin-decreases-post-absortive-energy-expenditure-at-rest-and-is-associated-to-greater-weight-gain-relative-to-sucrose-in-wistar-rats
#14
Denise Entrudo Pinto, Kelly Carraro Foletto, Ramiro Barcos Nunes, Pedro Dal Lago, Marcello Casaccia Bertoluci
BACKGROUND: Non-nutritive sweeteners (NNS) have been associated with increased prevalence of obesity. In previous studies, we demonstrated that saccharin could induce an increase in weight gain either when compared to sucrose or to a non-sweetened control at a similar total caloric intake. These data raised the hypothesis that reduced energy expenditure (EE) could be a potential mechanism explaining greater weight gain with saccharin use in rats. The aim of the present study was to compare long-term energy expenditure at rest between rats using saccharin or sucrose and correlate it with weight gain...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28205186/optimisation-of-cognitive-performance-in-rodent-operant-touchscreen-testing-evaluation-and-effects-of-reinforcer-strength
#15
Benjamin U Phillips, Christopher J Heath, Zofia Ossowska, Timothy J Bussey, Lisa M Saksida
Operant testing is a widely used and highly effective method of studying cognition in rodents. Performance on such tasks is sensitive to reinforcer strength. It is therefore advantageous to select effective reinforcers to minimize training times and maximize experimental throughput. To quantitatively investigate the control of behavior by different reinforcers, performance of mice was tested with either strawberry milkshake or a known powerful reinforcer, super saccharin (1.5% or 2% (w/v) saccharin/1.5% (w/v) glucose/water mixture)...
February 15, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/28196706/the-role-of-cell-cycle-progression-for-the-apoptosis-of-cancer-cells-induced-by-palladium-ii-saccharinate-complexes-of-terpyridine
#16
Omer Kacar, Buse Cevatemre, Ibrahim Hatipoglu, Nazli Arda, Engin Ulukaya, Veysel T Yilmaz, Ceyda Acilan
OBJECTIVES: Palladium complexes are potent and less toxic molecules in comparison to other metal based agents. Here, we characterized two palladium(II) saccharinate complexes with terpyridine for their cell cycle specificity. MATERIALS AND METHODS: Cells were arrested at G1, G1/S boundary or mitosis using mimosine, double-Thymidine block, aphidicolin, nocodazole or colcemid, and evaluated based on morphology and flow cytometry. Synchronized cells were treated with the Pd(II) complexes, and viability was measured via MTT assay...
January 31, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28192132/flavor-preferences-conditioned-by-nutritive-and-non-nutritive-sweeteners-in-mice
#17
Anthony Sclafani, Karen Ackroff
Recent studies suggest that preferences are conditioned by nutritive (sucrose) but not by non-nutritive (sucralose) sweeteners in mice. Here we compared the effectiveness of nutritive and non-nutritive sweeteners to condition flavor preferences in three mouse strains. Isopreferred sucrose and sucralose solutions both conditioned flavor preferences in C57BL/6J (B6) mice but sucrose was more effective, consistent with its post-oral appetition action. Subsequent experiments compared flavor conditioning by fructose, which has no post-oral appetition effect in B6 mice, and a sucralose+saccharin mixture (SS) which is highly preferred to fructose in 24-h choice tests...
May 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28148491/glucose-elicits-cephalic-phase-insulin-release-in-mice-by-activating-k-atp-channels-in-taste-cells
#18
John I Glendinning, Yonina G Frim, Ayelet Hochman, Gabrielle S Lubitz, Anthony J Basile, Anthony Sclafani
The taste of sugar elicits cephalic-phase insulin release (CPIR), which limits the rise in blood glucose associated with meals. Little is known, however, about the orosensory mechanisms that trigger CPIR. We asked whether oral stimulation with any of the following taste stimuli elicited CPIR in mice: glucose, sucrose, maltose, fructose, Polycose, saccharin, sucralose, AceK, SC45647 or a non-metabolizable sugar analog. The only taste stimuli that elicited CPIR were glucose and the glucose-containing saccharides (sucrose, maltose, Polycose)...
February 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28146272/ethanol-consumption-in-mice-lacking-cd14-tlr2-tlr4-or-myd88
#19
Yuri A Blednov, Mendy Black, Julia Chernis, Adriana Da Costa, Jody Mayfield, R Adron Harris
BACKGROUND: Molecular and behavioral studies support a role for innate immune proinflammatory pathways in mediating the effects of alcohol. Increased levels of Toll-like receptors (TLRs) have been observed in animal models of alcohol consumption and in human alcoholics, and many of these TLRs signal via the MyD88-dependent pathway. We hypothesized that this pathway is involved in alcohol drinking and examined some of its key signaling components. METHODS: Different ethanol (EtOH)-drinking paradigms were studied in male and female control C57BL/6J mice versus mice lacking CD14, TLR2, TLR4 (C57BL/10ScN), or MyD88...
March 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28138966/chronic-social-instability-in-adult-female-rats-alters-social-behavior-maternal-aggression-and-offspring-development
#20
Florent Pittet, Jessica A Babb, Lindsay Carini, Benjamin C Nephew
We investigated the consequences of chronic social instability (CSI) during adulthood on social and maternal behavior in females and social behavior of their offspring in a rat model. CSI consisted of changing the social partners of adult females every 2-3 days for 28 days, 2 weeks prior to mating. Females exposed to CSI behaved less aggressively and more pro-socially towards unfamiliar female intruders. Maternal care was not affected by CSI in a standard testing environment, but maternal behavior of CSI females was less disrupted by a male intruder...
January 31, 2017: Developmental Psychobiology
keyword
keyword
33530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"