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In vitro fertilization

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https://www.readbyqxmd.com/read/29684212/cadmium-exposure-of-female-mice-impairs-the-meiotic-maturation-of-oocytes-and-subsequent-embryonic-development
#1
Jia-Qiao Zhu, Yang Liu, Jiang-Hong Zhang, Yan-Fang Liu, Jiang-Qin Cao, Zhu-Tao Huang, Yan Yuan, Jian-Chun Bian, Zong-Ping Liu
Cadmium is one major pollutant that is highly toxic to animals and humans. The mechanism of cadmium toxicity on the female reproductive system, particularly oocyte maturation and fertility, remains to be clarified. In the present study, we used a mouse model to investigate the effects of cadmium in the drinking water on the meiotic maturation of oocytes and subsequent embryonic development, and the underlying mechanisms associated with the impairment of oocyte maturation such as mitochondrial distribution and histone modifications...
April 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29684038/murine-embryos-exposed-to-human-endometrial-mscs-derived-extracellular-vesicles-exhibit-higher-vegf-pdgf-aa-release-increased-blastomere-count-and-hatching-rates
#2
Rebeca Blázquez, Francisco Miguel Sánchez-Margallo, Verónica Álvarez, Elvira Matilla, Nuria Hernández, Federica Marinaro, María Gómez-Serrano, Inmaculada Jorge, Javier G Casado, Beatriz Macías-García
Endometrial Mesenchymal Stromal Cells (endMSCs) are multipotent cells with immunomodulatory and pro-regenerative activity which is mainly mediated by a paracrine effect. The exosomes released by MSCs have become a promising therapeutic tool for the treatment of immune-mediated diseases. More specifically, extracellular vesicles derived from endMSCs (EV-endMSCs) have demonstrated a cardioprotective effect through the release of anti-apoptotic and pro-angiogenic factors. Here we hypothesize that EV-endMSCs may be used as a co-adjuvant to improve in vitro fertilization outcomes and embryo quality...
2018: PloS One
https://www.readbyqxmd.com/read/29683988/case-report-ocular-myasthenia-gravis-associated-with-in-vitro-fertilization-procedures
#3
Yung Ju Yoo, Sang Beom Han, Hee Kyung Yang, Jeong-Min Hwang
SIGNIFICANCE: Ocular myasthenia gravis is a localized form of myasthenia gravis, which is a postsynaptic disorder of the neuromuscular junction that causes fluctuating weakness of extraocular muscles resulting from autoimmune mechanisms. In women with myasthenia, changes in sex hormone levels and administration of corticosteroids can trigger or worsen symptoms of myasthenia gravis. PURPOSE: To describe a case of seronegative ocular myasthenia gravis whose first symptom appeared a day after in vitro fertilization procedure...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29683366/predictive-value-of-basal-androgen-levels-on-ongoing-pregnancy-rates-during-in-vitro-fertilization-cycles
#4
Dan Pan, Juanzi Shi, Hanying Zhou, Na Li, Pengfei Qu
We aimed to evaluate the impact of elevated basal androgen levels on the endometrial receptivity. This study retrospectively enrolled 5278 fresh in vitro fertilization (IVF) cycles and sought to determine whether increased basal androgen levels are associated with adverse outcomes in regard to ongoing pregnancy rates. The results showed that the average age of our sample was 29.31 years. Almost 61.6% of all embryo transfers were with Day 3 embryos and the remaining 38.4% were with Day 5 embryos. The ongoing pregnancy rate was 56...
April 23, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29681745/breeding-of-fragrant-cyclamen-by-interspecific-hybridization-and-ion-beam-irradiation
#5
REVIEW
Hiroshi Ishizaka
Conventional breeding of cyclamen has relied on crossings among Cyclamen persicum cultivars without consideration of the scent of the flowers. Cyclamen purpurascens is a wild species with the most fragrant flowers in the genus Cyclamen. Allodiploid (2 n = 2 x = 41, AB) and allotriploid (2 n = 3 x = 65, AAB) plants have been produced from crosses of diploid and autotetraploid cultivars of C. persicum (2 n = 2 x = 48, AA; 4 x = 96, AAAA) × diploid wild C. purpurascens (2 n = 2 x = 34, BB) by embryo rescue, but are sterile...
January 2018: Breeding Science
https://www.readbyqxmd.com/read/29681721/progesterone-hypersensitivity-a-challenge-for-luteal-support
#6
Astha Gupta, Deepak Goenka, Mohan L Goenka
Progesterone hypersensitivity is a rare phenomenon which can occur after both endogenous and exogenous exposures. We present a case of hypersensitivity to various forms and routes of exogenous progesterone. A 27-year-old female presented with primary infertility. Investigations revealed Grade 1 endometriosis and polycystic ovary syndrome. Three cycles of intrauterine insemination were attempted which were unsuccessful and in vitro fertilization was proceeded. Six blastocysts of Grade A were formed and cryopreserved...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681717/luteinizing-hormone-receptor-gene-and-regulator-of-g-protein-signaling-2-gene-expression-level-and-association-with-oocyte-maturity-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycle
#7
Thanik Chokjirawat, Mutchuporn Sukpresert, Wicharn Choktanasiri, Wanwisa Waiyaput, Duangporn Saengwimol, Aruchalean Taweewongsounton, Tanjitti Pongrujikorn, Chonthicha Satirapod
Aims: The aim is to study the relation and distribution in gene expression level of the luteinizing hormone receptor (LHR) gene and regulator of G-protein signaling 2 (RGS2) gene expression with oocyte maturation. Setting and Design: This cross-sectional study was undertaken in an instruction-based tertiary care infertility unit, department of obstetrics and gynecology. Materials and Methods: After controlled ovarian hyperstimulation, cumulus granulosa cells (CCs) from 59 oocytes among 18 women being treated by in vitro fertilization/intracytoplasmic sperm injection cycle technique from November 2015 to January 2016 were collected on the day of oocyte retrieval...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681716/equivalency-of-in-vitro-fertilization-success-rates-in-elective-single-blastocyst-transfer-and-elective-double-blastocyst-transfer-an-example-of-equivalence-methodology-in-clinical-reproductive-health
#8
Marni B Jacobs, Hillary Klonoff-Cohen, V Gabriel Garzo
Context: When comparing success rates between treatments, it is more appropriate to structure analyses in terms of equivalence rather than traditional analyses that assess differences. Unfortunately, no studies of elective single blastocyst transfer (eSBT) have been conducted in this manner. Aims: The objective of this study was to assess clinical equivalence of in vitro fertilization success rates among patients undergoing eSBT. Settings and Design: A historical prospective study was conducted at a private fertility center...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681715/can-intracytoplasmic-morphologically-selected-spermatozoa-injection-be-used-as-first-choice-of-treatment-for-severe-male-factor-infertility-patients
#9
Geeta Goswami, Meeta Sharma, Deepika Jugga, Devi M Gouri
Aim: This study was carried out to assess the outcome of the intracytoplasmic morphologically selected sperm injection (IMSI) technique compared with the previous failed intracytoplasmic sperm injection (ICSI) attempts in oligoasthenoteratozoospermia (OAT)/severe OAT (SOAT)/teratozoospermia patients. Setting: Institution-based, in vitro fertilization center. Study Design: It was a nonrandomized prospective study including 57 couples who had previous one or two ICSI failures (failure due to no implantation as embryos were transferred in these cycles and had no pregnancy) due to male factor...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681712/effectiveness-of-anti-mullerian-hormone-tailored-protocol-compared-to-conventional-protocol-in-women-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#10
Sumi Thomas, Mousumi Acharya, K Muthukumar, Achamma Chandy, Mohan S Kamath, T K Aleyamma
Background: Assessment of ovarian reserve before an in vitro fertilization cycle (IVF) is one among the many factors that predicts a successful cycle. Individualized protocol based on ovarian reserve is designed to optimize the pregnancy outcome without compromising the patient safety. Although authors have shown that anti-Mullerian hormone-tailored (AMH) protocols have reduced the treatment burden and improved pregnancy rates, a few others have questioned its efficacy. Aims: The aim of this study was to decide whether the AMH-tailored protocol or the conventional protocol better decides IVF outcomes...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681709/mitochondrial-donation-a-boon-or-curse-for-the-treatment-of-incurable-mitochondrial-diseases
#11
REVIEW
Nishtha Saxena, Nancy Taneja, Prakriti Shome, Shalini Mani
Mitochondria are present in all human cells and vary in number from a few tens to many thousands. As they generate the majority of a cell's energy supply which power every part of our body, and hence, their number varies in different cells as per the energy requirement of the cell. Mitochondria have their own separate DNA, which carries total 13 genes. All of these 13 genes are involved in energy production. For normal functioning of cells, the mitochondria need to be healthy. Unhealthy mitochondria can cause severe medical disorders known as mitochondrial disease...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681196/congenital-heart-defects-according-to-the-types-of-the-risk-factors-a-single-center-experience
#12
Jan Pavlicek, Eva Klaskova, Martin Prochazka, Erika Dolezalkova, David Matura, Richard Spacek, Ondrej Simetka, Tomas Gruszka, Slavka Polanska, Marian Kacerovsky
OBJECTIVE: The main aim of this study was to compare the prevalence of congenital heart defects (CHDs) between pregnant women with and those without the risk factors. The secondary aim was to determine the influence of the specific risk factors, divided into subgroups, on the development of the CHD. METHODS: The presented results were obtained over the course of a 15-year study between years 2002 and 2016. Fetal echocardiography was performed as a planned screening examination during the second trimester of gravidity...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29679980/parental-genetic-material-and-oxygen-concentration-affect-hatch-dynamics-of-mouse-embryo-in-vitro
#13
Shaoquan Zhan, Shanbo Cao, Hongzi Du, Yuan Sun, Li Li, Chenhui Ding, Haiyan Zheng, Junjiu Huang
BACKGROUND: Hatching is crucial for mammalian embryo implantation, since difficulties during this process can lead to implantation failure, ectopic pregnancy and consequent infertility. Despite years of intensive researches, how internal and external factors affecting embryo hatch are still largely unclear. METHODS: The effects of parental genetic material and oxygen concentration on hatch process were examined. Fertilized and parthenogenetic mouse preimplantation embryos were cultured in vitro under 5 and 20% oxygen for 120 h...
April 21, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29679182/non-o-blood-group-and-outcomes-of-in-vitro-fertilization
#14
M Di Nisio, A Ponzano, G M Tiboni, M D Guglielmi, A W S Rutjes, E Porreca
PURPOSE: Retrospective and cross-sectional studies suggested that non-O blood group may be associated with failures of in vitro fertilization (IVF), but data remain controversial. The aim of this observational cohort study was to prospectively evaluate the effect of non-O blood type on clinical outcomes of IVF. METHODS: Women < 40 years who underwent IVF and had ABO blood type recorded as part of the routine workup were eligible. The primary study outcome was live birth...
April 20, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29675491/hypertensive-disorders-of-in-vitro-fertilization-pregnancies-a-study-from-kosovo
#15
Merita Vuniqi-Krasniqi, Myrvete Paçarada, Qëndresë Daka, Zeqir Dervishi, Astrit Bimbashi, Kushtrim Dakaj
Background: Relationships between in-vitro fertilization (IVF), gestational hypertension, and pregnancy outcomes are demonstrated in a number of studies. However, it is still debated if IVF treatment or specific characteristics of infertile patients are responsible for worse obstetrical and neonatal outcomes. Objective: The aim of this study was to investigate maternal characteristics associated with hypertensive disorders (HD) in IVF conceived pregnancies and to assess the obstetrical and neonatal outcomes...
February 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29675483/fresh-versus-frozen-embryo-transfer-after-gonadotropin-releasing-hormone-agonist-trigger-in-gonadotropin-releasing-hormone-antagonist-cycles-among-high-responder-women-a-randomized-multi-center-study
#16
Abbas Aflatoonian, Mahnaz Mansoori-Torshizi, Maryam Farid Mojtahedi, Behrouz Aflatoonian, Mohammaad Ali Khalili, Mohammad Hossein Amir-Arjmand, Mehrdad Soleimani, Nastaran Aflatoonian, Homa Oskouian, Nasim Tabibnejad, Peter Humaidan
Background: The use of embryo cryopreservation excludes the possible detrimental effects of ovarian stimulation on the endometrium, and higher reproductive outcomes following this policy have been reported. Moreover, gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone (GnRH) antagonist cycles as a substitute for standard human chorionic gonadotropin trigger, minimizes the risk of ovarian hyperstimulation syndrome (OHSS) in fresh as well as frozen embryo transfer cycles (FET)...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29673675/the-association-between-in-vitro-fertilization-outcome-and-the-inflammatory-markers-of-complete-blood-count-among-nonobese-unexplained-infertile-couples
#17
Esra Nur Tola
OBJECTIVE(S): The purpose of our study was to evaluate whether the inflammatory parameters of complete blood count (CBC), including white blood cell (WBC), neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR), and mean platelet volume (MPV), had potential roles in the etiopathogenesis of unexplained infertility (UI) among nonobese women. We also aimed to investigate whether there could be an association between these markers and in vitro fertilization (IVF) success among nonobese women with UI...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29672006/physiological-icsi-picsi-vs-conventional-icsi-in-couples-with-male-factor-a-systematic-review
#18
Georgina Avalos-Durán, Ana María Emilia Cañedo-Del Ángel, Juana Rivero-Murillo, Jaime Enoc Zambrano-Guerrero, Esperanza Carballo-Mondragón, Miguel Ángel Checa-Vizcaíno
OBJECTIVES: To determine the efficacy of the physiological ICSI technique (PICSI) vs. conventional ICSI in the prognosis of couples, with respect to the following outcome measures: live births, clinical pregnancy, implantation, embryo quality, fertilization and miscarriage rates. METHODS: A systematic review of the literature, extracting raw data and performing data analysis. Patient(s): Couples with the male factor, who were subjected to in-vitro fertilization...
April 19, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29671923/sucrose-assists-selection-of-high-quality-oocytes-in-pigs
#19
Thanh Quang Dang-Nguyen, Hiep Thi Nguyen, Tamas Somfai, David Wells, Nguyen Thi Men, Nguyen Viet-Linh, Junko Noguchi, Hiroyuki Kaneko, Kazuhiro Kikuchi, Takashi Nagai
We investigated whether high-quality in vitro matured (IVM) oocytes can be distinguished from poor ones based on the morphological changes after treatment with hyperosmotic medium containing 0.2 mol/L sucrose in pigs. We hypothesize that IVM oocytes maintaining round shape have higher quality than mis-shapened oocytes following dehydration. Oocyte quality was verified by determining embryonic developmental competence using in vitro fertilization, nuclear transfer and parthenogenetic activation. In all cases, the round oocytes had greater (p < ...
April 19, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29671650/early-outcomes-of-a-municipally-funded-oocyte-cryopreservation-programme-in-japan
#20
Iwaho Kikuchi, Noriko Kagawa, Yuka Shirosaki, Ikumi Shinozaki, Yasuka Miyakuni, Kyoko Oshina, Michio Nojima, Koyo Yoshida
One factor explaining the declining birth rate in Japan is the social advancement of women. Women are delaying marriage and childbirth, with many then facing so-called 'social infertility'. Advanced infertility treatment options, such as in vitro fertilization, are available, but the costs are high. Further, the success rates for 'older' women are only around 10%. We report the preliminary results of an oocyte cryopreservation programme promoted and subsidized by our city government. Citywide seminars were conducted to generate awareness of issues surrounding fertility...
April 19, 2018: Human Fertility: Journal of the British Fertility Society
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