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Vit D

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https://www.readbyqxmd.com/read/29308676/vitamin-d-protection-from-rat-diabetic-nephropathy-is-partly-mediated-through-klotho-expression-and-renin-angiotensin-inhibition
#1
Nashwa Eltablawy, Hend Ashour, Laila Ahmed Rashed, Wael Mostafa Hamza
OBJECTIVE: We hypothesised that vitamin D has a beneficial renal protective effect from diabetic nephropathy (DN). METHODS: Four rat groups were included: normal control (control), type 2 diabetes for eight weeks (DM), treated group with angiotensin receptor blocker losartan (DM + L), and vitamin D-treated group started from the onset of diabetes (DM + Vit D). RESULTS: In the both treated groups, we found a significant (p < ...
January 8, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29243839/correlation-of-vitamin-d-and-vitamin-d-receptor-expression-in-patients-with-alopecia-areata-a-clinical-paradigm
#2
Manju Daroach, Tarun Narang, Uma N Saikia, Naresh Sachdeva, Muthu Sendhil Kumaran
BACKGROUND: Vitamin D (Vit.D) deficiency has been reported in alopecia areata (AA). Downregulation of Vitamin D receptor (VDR) on hair follicles is associated with reduced hair growth. OBJECTIVE: To correlate serum Vit.D levels with severity, pattern, and duration of AA, and density of VDR expression over hair follicles in AA patients. METHODS: Prospective study including 30 AA patients and 30 healthy controls. Clinical details and serum Vit...
December 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29221946/-facing-a-dilemma-in-elderly-complex-and-vulnerable-patients-to-stop-or-not-to-stop-prevention
#3
Laura Llobet Vila, Josep Maria Manresa Domínguez, José Manuel Carmona Segado, Alícia Franzi Sisó, Rosa Vallès Balasch, Isabel Martínez Díaz
OBJECTIVES: 1-To know the preventive prescription (statin, antiplatelet drugs, bisphosphonates, calcium and vitamin D and Vit B12) of elderly patients previously identified as a CCD (with a complex chronic disease) and ACD (with advanced chronic disease and lifetime expectancy of less than 12 months) who died during 2015. 2-To assess the correct indication of Proton Pump Inhibitors (PPI) to determine potentially avoidable medication. DESIGN: Retrospective observational study...
December 5, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29192811/effects-of-vitamin-d-on-ovary-in-dhea-treated-pcos-rat-model-a-light-and-electron-microscopic-study
#4
Latife Seyran Çelik, Yurdun Kuyucu, Ebru Dündar Yenilmez, Abdullah Tuli, Kenan Dağlıoğlu, Ufuk Özgü Mete
AIM: The aim of this study was to investigate the effects of vitamin D treatment on ovary in experimentally designed polycystic ovary syndrome of female rats using light and electron microscopic techniques. METHODS: Twenty-four female pre-pubertal rats were divided into control, DHEA and DHEA+Vit.D groups. In DHEA group, the PCOS rat model was developed by 6mg/kg/day dehydroepiandrosterone administration as subcutaneously injections. In DHEA+Vit.D group, 6 mg/kg/day DHEA and 120ng/100g/week 1,25(OH)2D3 was performed simultaneously...
December 1, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29179679/attenuating-the-rate-of-total-body-fat-accumulation-and-alleviating-liver-damage-by-oral-administration-of-vitamin-d-enriched-edible-mushrooms-in-a-diet-induced-obesity-murine-model-is-mediated-by-an-anti-inflammatory-paradigm-shift
#5
A Drori, D Rotnemer-Golinkin, S Avni, A Drori, O Danay, D Levanon, J Tam, L Zolotarev, Y Ilan
BACKGROUND: Hypovitaminosis D is associated with many features of the metabolic syndrome, including non-alcoholic fatty liver disease. Vitamin D-enriched mushrooms extracts exert a synergistic anti-inflammatory effect. The aim of the present study is to determine the immunomodulatory effect of oral administration of vitamin D-enriched mushrooms extracts on high-fat diet (HFD) animal model of non-alcoholic steatohepatitis (NASH). METHODS: C57BL/6 mice on HFD were orally administered with vitamin D supplement, Lentinula edodes (LE) mushrooms extract, or vitamin D-enriched mushrooms extract for 25 weeks...
November 28, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29177013/vitamin-d-is-associated-with-metabotropic-but-not-neurotrophic-effects-of-exercise-in-ovariectomized-rats
#6
Parvin Babaei, Samaneh Ghorbani Shirkouhi, Rastegar Hosseini, Bahram Soltani Tehrani
Purpose: Here, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different serum vitamin D (Vit D) status. Methods: Eighty female wistar rats were divided into 2 groups of sham operated (sham, n = 8), and ovariectomized (OVX, n = 72). Then OVX were divided into 9 groups of receiving combination of exercise protocol with low dose of Vit D (OVX + EXE + LD), high dose of Vit D (OVX + EXE + HD), Vit D deficiency (OVX + EXE - D), and (OVX + EXE + Veh)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29165650/evaluation-of-1-25-dihydroxyvitamin-d3-pathway-in-patients-with-chronic-urticaria
#7
Rasoul Nasiri-Kalmarzi, Mohammad Abdi, Javad Hosseini, Erfan Babaei, Aram Mokarizadeh, Zakaria Vahabzadeh
BACKGROUND: Previous studies showed the role of vitamin D (Vit D) on the progression of chronic urticaria. To the best of our knowledge, there are no other results regarding the contribution of single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes in Chronic Urticaria (CU). AIM: In the present study, we investigated the Vit pathway and the association between VDR and VDBP gene polymorphisms and CU risk in Iranian population...
November 20, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29148924/influence-of-gestational-diabetes-on-the-activity-of-%C3%AE-aminolevulinate-dehydratase-and-oxidative-stress-biomarkers
#8
Fabiane Rodrigues, Leidiane de Lucca, Walter S Neme, Thissiane de Lima Gonçalves
OBJECTIVES: This study aimed to evaluate the activity of delta-aminolevulinate dehydratase (δ-ALA-D) and oxidative stress biomarkers in pregnant women with gestational diabetes mellitus (GDM), in order to demonstrate the involvement of oxidative stress in this condition, which presents pathophysiology still undetermined. METHODS: δ-ALA-D activity, lipid peroxidation estimated as the levels of thiobarbituric acid reactive substances (TBARS), protein (P-SH) and non-protein thiol (NP-SH) content, catalase (CAT) activity and concentration of vitamin C (VIT C) in samples of pregnant women with GDM (n = 48) and in healthy pregnant women (n = 30), who constituted the control group...
November 17, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29130299/-role-of-vitamin-d-in-female-reproduction
#9
Vincenzo DE Leo, Valentina Cappelli, Giuseppe Morgante, Alessandra DI Sabatino
La vit. D, o calcitriolo, è stata identificata inizialmente nei primi anni '20 ed ha un ruolo chiave nella regolazione del metabolismo osseo, nell'omeostasi del calcio e del fosforo e nel promuovere la mineralizzazione ossea. Le azioni della vit. D sono mediante tramite un recettore nucleare (VDR), che è espresso in numerosi organi come l'intestino, l'osso e il rene, ma anche nelle gonadi, nel seno, nel pancreas, nel sistema cardiovascolare, nel cervello (microglia) e nelle cellule del sistema immunitario...
November 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29114197/low-levels-of-vitamin-d-an-emerging-risk-for-cardiovascular-diseases-a-review
#10
REVIEW
Farrukh Majeed
Sunlight is regarded among greatest gifts that are presented in abundance to the human beings from the God. Sunlight is also a rich source of Vitamin D (Vit D) that prevents us from numerous ailments such as autoimmune disorders, various types of cancer, and the above all cardiovascular diseases (CVD). Evident from recent research that Vit D deficiency may be the cause for hypertension, cardiac autonomic imbalance, vascular endothelial dysfunction, metabolic syndrome, and even diabetes. Concurrently, many studies present research outcomes that are contradictory to earlier results and also raised a concern not for general public but also among their treating physicians...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29075077/bone-histo-morphology-in-chronic-kidney-disease-mineral-bone-disorder
#11
Khuraijam Bembem, Tejinder Singh, Narinder Pal Singh, Alpana Saxena, Shyama Lata Jain
Chronic Kidney Disease-Mineral Bone Disorder(CKD-MBD) is a systemic disorder of the mineral and bone metabolism seen in patients with Chronic Kidney Disease(CKD). It is manifested by either one or a combination of the following: (a) Abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism. (b) Abnormalities in bone turnover, mineralization, volume, linear growth, or strength. (c) Vascular or other soft- tissue calcification. Renal osteodystrophy measures the skeletal component of CKD-MBD. To study the histomorphology of bone marrow biopsy in patients with CKD-MBD and correlate the histological features of bone biopsy with the clinicobiochemical parameters...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29040674/evaluation-of-apoptotic-and-autophagic-related-protein-expressions-before-and-after-ivm-of-fresh-slow-frozen-and-vitrified-pre-pubertal-mouse-testicular-tissue
#12
L Dumont, F Chalmel, A Oblette, B Berby, A Rives, V Duchesne, C Rondanino, N Rives
STUDY QUESTION: Do freezing and in vitro culture procedures enhance the expression of proteins involved in apoptotic or autophagic pathways in murine pre-pubertal testicular tissue? SUMMARY ANSWER: IVM strongly modified apoptosis- and autophagy-related relative protein levels in mice testicular tissue whereas the impact of cryopreservation procedures was minimal at the end of the culture. WHAT IS KNOWN ALREADY: In vitro spermatogenesis remains a challenging technical issue as it imposes to find a very close balance between survival and death of germ cell natural precursors (i...
November 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28989587/high-prevalence-of-vitamin-d-deficiency-in-newly-diagnosed-acute-myeloid-leukemia-patients-and-its-adverse-outcome
#13
Fatere Seyedalipour, Ava Mansouri, Mohammad Vaezi, Kheirollah Gholami, Kazem Heidari, Molouk Hadjibabaie, Ardeshir Ghavamzadeh
Background: Although several studies have supported a preventive and therapeutic role of vitamin D (Vit D) for different types of cancers, we face insufficient documentation in acute myeloid leukemia (AML). So, we examined whether the serum calcidiol (25(OH)D) levels at the time of induction therapy have any impact on response and relapse in AML patients. Materials and Methods: Blood samples were collected from 65 patients on days 0 and 28th of treatment to evaluate serum concentration of 25(OH)D and its effects on complete remission (CR) achievement, relapse rate and hospitalization length...
July 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28949229/first-measurement-of-transverse-spin-dependent-azimuthal-asymmetries-in-the-drell-yan-process
#14
M Aghasyan, R Akhunzyanov, G D Alexeev, M G Alexeev, A Amoroso, V Andrieux, N V Anfimov, V Anosov, A Antoshkin, K Augsten, W Augustyniak, A Austregesilo, C D R Azevedo, B Badełek, F Balestra, M Ball, J Barth, R Beck, Y Bedfer, J Bernhard, K Bicker, E R Bielert, R Birsa, M Bodlak, P Bordalo, F Bradamante, A Bressan, M Büchele, W-C Chang, C Chatterjee, M Chiosso, I Choi, S-U Chung, A Cicuttin, M L Crespo, S Dalla Torre, S S Dasgupta, S Dasgupta, O Yu Denisov, L Dhara, S V Donskov, N Doshita, Ch Dreisbach, W Dünnweber, M Dziewiecki, A Efremov, P D Eversheim, M Faessler, A Ferrero, M Finger, M Finger, H Fischer, C Franco, N du Fresne von Hohenesche, J M Friedrich, V Frolov, E Fuchey, F Gautheron, O P Gavrichtchouk, S Gerassimov, J Giarra, F Giordano, I Gnesi, M Gorzellik, A Grasso, M Grosse Perdekamp, B Grube, T Grussenmeyer, A Guskov, D Hahne, G Hamar, D von Harrach, F H Heinsius, R Heitz, F Herrmann, N Horikawa, N d'Hose, C-Y Hsieh, S Huber, S Ishimoto, A Ivanov, Yu Ivanshin, T Iwata, V Jary, R Joosten, P Jörg, E Kabuß, A Kerbizi, B Ketzer, G V Khaustov, Yu A Khokhlov, Yu Kisselev, F Klein, J H Koivuniemi, V N Kolosov, K Kondo, K Königsmann, I Konorov, V F Konstantinov, A M Kotzinian, O M Kouznetsov, Z Kral, M Krämer, P Kremser, F Krinner, Z V Kroumchtein, Y Kulinich, F Kunne, K Kurek, R P Kurjata, A Kveton, A A Lednev, M Levillain, S Levorato, Y-S Lian, J Lichtenstadt, R Longo, A Maggiora, A Magnon, N Makins, N Makke, G K Mallot, B Marianski, A Martin, J Marzec, J Matoušek, H Matsuda, T Matsuda, G V Meshcheryakov, M Meyer, W Meyer, Yu V Mikhailov, M Mikhasenko, E Mitrofanov, N Mitrofanov, Y Miyachi, A Nagaytsev, F Nerling, D Neyret, J Nový, W-D Nowak, G Nukazuka, A S Nunes, A G Olshevsky, I Orlov, M Ostrick, D Panzieri, B Parsamyan, S Paul, J-C Peng, F Pereira, M Pešek, D V Peshekhonov, N Pierre, S Platchkov, J Pochodzalla, V A Polyakov, J Pretz, M Quaresma, C Quintans, S Ramos, C Regali, G Reicherz, C Riedl, N S Rogacheva, M Roskot, D I Ryabchikov, A Rybnikov, A Rychter, R Salac, V D Samoylenko, A Sandacz, C Santos, S Sarkar, I A Savin, T Sawada, G Sbrizzai, P Schiavon, K Schmidt, H Schmieden, K Schönning, E Seder, A Selyunin, O Yu Shevchenko, L Silva, L Sinha, S Sirtl, M Slunecka, J Smolik, A Srnka, D Steffen, M Stolarski, O Subrt, M Sulc, H Suzuki, A Szabelski, T Szameitat, P Sznajder, S Takewaka, M Tasevsky, S Tessaro, G Terça, F Tessarotto, A Thiel, J Tomsa, F Tosello, V Tskhay, S Uhl, A Vauth, J Veloso, M Virius, M Vit, J Vondra, S Wallner, T Weisrock, M Wilfert, J Ter Wolbeek, K Zaremba, P Zavada, M Zavertyaev, E Zemlyanichkina, N Zhuravlev, M Ziembicki
The first measurement of transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan (DY) process is reported. We use the CERN SPS 190  GeV/c π^{-} beam and a transversely polarized ammonia target. Three azimuthal asymmetries giving access to different transverse-momentum-dependent (TMD) parton distribution functions (PDFs) are extracted using dimuon events with invariant mass between 4.3  GeV/c^{2} and 8.5  GeV/c^{2}. Within the experimental uncertainties, the observed sign of the Sivers asymmetry is found to be consistent with the fundamental prediction of quantum chromodynamics (QCD) that the Sivers TMD PDFs extracted from DY have a sign opposite to the one extracted from semi-inclusive deep-inelastic scattering (SIDIS) data...
September 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28942016/positron-emission-tomography-based-assessment-of-metabolic-tumor-volume-predicts-survival-after-autologous-hematopoietic-cell-transplantation-for-hodgkin-lymphoma
#15
Vít Procházka, Rakhee S Gawande, Zuzan Cayci, Jerry W Froelich, Qing Cao, Chris Wilke, Kathryn Dusenbery, Daniel J Weisdorf, Veronika Bachanova
Autologous hematopoietic cell transplantation (AHCT) is curative for 60% of patients with relapsed or refractory Hodgkin lymphoma (R/R HL). A more precise assessment of the depth of remission before AHCT may help to identify patients likely to benefit from AHCT. We aimed to determine whether positron emission tomography (PET)-based quantitative parameters of total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), and maximal standardized uptake volume (SUVmax) measured before AHCT predict progression-free survival (PFS) after transplant...
September 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28893306/monitored-supplementation-of-vitamin-d-in-preterm-infants-mosvid-trial-study-protocol-for-a-randomised-controlled-trial
#16
Alicja Kołodziejczyk, Maria K Borszewska-Kornacka, Joanna Seliga-Siwecka
BACKGROUND: The pivotal role of vitamin D (vit D) in skeletal health is well known. Neonatal vit D storage at birth is dependent on maternal levels, and newborns receive 50-70% of their mother's 25-hydroxyvitamin D [25(OH)D]. Deficiency of vit D can lead to prematurity bone disease, with an incidence of up to 55% in infants weighing < 1000 g. The aim of this study is to assess the effectiveness of monitored supplementation of vit D in a population of preterm infants. METHODS/DESIGN: Preterm infants born at 24-32 weeks of gestation will be recruited within the first 7 days of life...
September 11, 2017: Trials
https://www.readbyqxmd.com/read/28879647/evaluation-of-vitamin-d-concentration-in-a-population-of-young-healthy-women-effects-of-vitamin-d-supplementation
#17
Ewa Sewerynek, Karol Cieślak, Małgorzata Janik, Ewelina Gowin, Michał Stuss
The goal of the study was an evaluation of serum vitamin D concentrations in healthy young women. MATERIAL AND METHODS: 106 healthy women, aged 20-30 years, were included in the study. Monthly evaluation - for three months - of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women with baseline values of vit. D < 20 ng/ml (Group 1) plus the effects of 800 IU/d dose in women with the baseline value of D > 20 ng/ml (Group2). Additionally, calcium and PTH concentrations were assessed at the study onset and after a 3-month supplementation...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28864378/potential-cardiovascular-and-renal-protective-effects-of-vitamin-d-and-coenzyme-q10-in-l-name-induced-hypertensive-rats
#18
Hanan A Shamardl, Sahar M El-Ashmony, Hala F Kamel, Sameer H Fatani
BACKGROUND: Hypertension is one of the primary modifiable risk factors for cardiovascular disease. Adequate vitamin D (vit D) levels have been shown to reduce vascular smooth muscle contraction and to increase arterial compliance, which may be beneficial in hypertension. Further, coenzyme Q10 (COQ10) through its action to lower oxidative stress has been reported to have beneficial effects on hypertension and heart failure. This study examined the possible cardiac and renal protective effects of vit D and COQ10 both separately and in combination with an angiotensin II receptor blocker, valsartan (vals) in l-NAME hypertensive rats...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28858890/fat-soluble-micronutrients-and-metabolic-syndrome
#19
Aurélie Goncalves, Marie-Josèphe Amiot
PURPOSE OF REVIEW: Metabolic syndrome (MetS) is associated with increased risk of obesity, type 2 diabetes mellitus and cardiovascular diseases. MetS prevalence has been associated with diet inadequacy. Conversely, the cumulative incidence of MetS has been inversely associated with a Mediterranean-style diet that includes many different health-beneficial nutrients. Adherence to a Mediterranean-style diet could reduce or at least stabilize metabolic risk factors. RECENT FINDINGS: Low serum level of fat-soluble micronutrients, such as carotenoids, vitamin (vit) A, D and E, has been linked to MetS...
November 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28831601/endothelin-1-%C3%AE-klotho-25-oh-vit-d-levels-and-severity-of-disease-in-scleroderma-patients
#20
Mehrzad Hajialilo, Parisa Noorabadi, Sepideh Tahsini Tekantapeh, Aida Malek Mahdavi
Considering the role of endothelin-1 (ET-1) in tissue remodeling and fibrosis during the development of scleroderma as well as the effect of α-Klotho in pathogenesis of calcinosis and/or endothelial cell injury and its correlation with severity of disease, this study aimed to evaluate serum ET-1, α-Klotho and 25(OH) vitamin D levels in patients with limited and diffuse scleroderma compared to healthy subjects. In this cross-sectional study, 60 scleroderma patients according to the ACR/EULAR 2013 criteria and 60 age- and sex-matched healthy controls were included...
October 2017: Rheumatology International
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