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https://www.readbyqxmd.com/read/28335206/cytotoxic-induction-and-photoacoustic-imaging-of-breast-cancer-cells-using-astaxanthin-reduced-gold-nanoparticles
#1
Subramaniyan Bharathiraja, Panchanathan Manivasagan, Nhat Quang Bui, Yun-Ok Oh, In Gweon Lim, Suhyun Park, Junghwan Oh
Astaxanthin, a kind of photosynthetic pigment, was employed for gold nanoparticle formation. Nanoparticles were characterized using Ulteraviolet-Visible (UV-Vis) spectroscopy, transmission electron microscopy, and X-ray diffraction, and the possible presence of astaxanthin functional groups were analyzed by Fourier transform infrared spectroscopy (FTIR). The cytotoxic effect of synthesized nanoparticles was evaluated against MDA-MB-231 (human breast cancer cells) using a tetrazolium-based assay, and synthesized nanoparticles exhibited dose-dependent toxicity...
April 20, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28331788/periodic-mesoporous-organosilica-coated-prussian-blue-for-mr-pa-dual-modal-imaging-guided-photothermal-chemotherapy-of-triple-negative-breast-cancer
#2
Wei Tian, Yunyan Su, Ying Tian, Shouju Wang, Xiaodan Su, Ying Liu, Yunlei Zhang, Yuxia Tang, Qianqian Ni, Wenfei Liu, Meng Dang, Chunyan Wang, Junjie Zhang, Zhaogang Teng, Guangming Lu
Complete eradication of highly aggressive triple negative breast cancer (TNBC) remains a notable challenge today. In this work, an imaging-guided photothermal-chemotherapy strategy for TNBC is developed for the first time based on a periodic mesoporous organosilica (PMO) coated Prussian blue (PB@PMO) nanoplatform. The PB@PMOs have organic-inorganic hybrid frameworks, uniform diameter (125 nm), high surface area (866 m(2) g(-1)), large pore size (3.2 nm), excellent photothermal conversion capability, high drug loading capacity (260 µg mg(-1)), and magnetic resonance (MR) and photoacoustic (PA) imaging abilities...
March 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28328150/yolk-shell-nanostructure-an-ideal-architecture-to-achieve-harmonious-integration-of-magnetic-plasmonic-hybrid-theranostic-platform
#3
Li-Sen Lin, Xiangyu Yang, Zijian Zhou, Zhen Yang, Orit Jacobson, Yijing Liu, Angela Yang, Gang Niu, Jibin Song, Huang-Hao Yang, Xiaoyuan Chen
Magnetic-plasmonic hybrid nanoparticles (MPHNs) have attracted great interest in cancer theranostics. However, the relaxivity of the magnetic component is typically reduced by the plasmonic component in conventional core-shell structured MPHNs, due to the presence of a water-impenetrable coating which severely restricts the proximity of protons to the magnetic portion. To circumvent this issue, yolk-shell structured MPHNs comprising a Fe3 O4 core within a hollow cavity encircled by a porous Au outer shell are designed...
March 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28327582/real-time-sentinel-lymph-node-biopsy-guidance-using-combined-ultrasound-photoacoustic-fluorescence-imaging-in-vivo-proof-of-principle-and-validation-with-nodal-obstruction
#4
Jeeun Kang, Jin Ho Chang, Sun Mi Kim, Hak Jong Lee, Haemin Kim, Brian C Wilson, Tai-Kyong Song
Precise sentinel lymph node (SLN) identification is crucial not only for accurate diagnosis of micro-metastases at an early stage of cancer progression but also for reducing the number of SLN biopsies (SLNB) to minimize their severe side effects. Furthermore, it is desirable that an SLNB guidance should be as safe as possible in routine clinical use. Although there are currently various SLNB guidance methods for pre-operative or intra-operative assessment, none are ideal. We propose a real-time SLNB guidance method using contrast-enhanced tri-modal images (i...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327075/magnetic-nanobubbles-with-potential-for-targeted-drug-delivery-and-trimodal-imaging-in-breast-cancer-an-in-vitro-study
#5
Weixiang Song, Yindeng Luo, Yajing Zhao, Xinjie Liu, Jiannong Zhao, Jie Luo, Qunxia Zhang, Haitao Ran, Zhigang Wang, Dajing Guo
AIM: The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. MATERIALS & METHODS: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIO-HER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging...
March 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28324863/croconaine-nanoparticles-with-enhanced-tumor-accumulation-for-multimodality-cancer-theranostics
#6
Longguang Tang, Fuwu Zhang, Fei Yu, Wenjing Sun, Menglin Song, Xiaoyuan Chen, Xianzhong Zhang, Xiaolian Sun
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention)...
March 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28301720/terrylenediimide-based-intrinsic-theranostic-nanomedicines-with-high-photothermal-conversion-efficiency-for-photoacoustic-imaging-guided-cancer-therapy
#7
Shaobo Zhang, Weisheng Guo, Jie Wei, Chan Li, Xing-Jie Liang, Meizhen Yin
Activatable theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, the theranostic nanomedicines widely suffer from instability and complicated nanostructures, which hamper potential clinical applications. Herein, we demonstrated a terrylenediimide-poly(acrylic acid) (TPA)-based nanomedicine (TNM) platform used as an intrinsic theranostic agent. As an exploratory paradigm in seeking biomedical applications, terrylenediimide (TDI) was modified with poly(acrylic acid)s (PAAs), resulting in eight-armed, star-like TPAs composed of an outside hydrophilic PAA corona and an inner hydrophobic TDI core...
March 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28299923/amphiphilic-semiconducting-oligomer-for-near-infrared-photoacoustic-and-fluorescence-imaging
#8
Chao Yin, Xu Zhen, Hui Zhao, Yufu Tang, Yu Ji, Yan Lyu, Quli Fan, Wei Huang, Kanyi Pu
Semiconducting polymer nanoparticles (SPNs) have emerged as an alternative class of optical nanoagents for imaging applications. However, the general preparation method for SPNs is nanoprecipitation, which is likely to encounter the issue of nanoparticle dissociation. We herein report non-dissociable near-infrared (NIR)-absorbing organic semiconducting nanoparticles for in vivo photoacoustic (PA) and fluorescence imaging. The nanoparticles are self-assembled from an amphiphilic semiconducting oligomer (ASO) that has a hydrophobic semiconducting oligomer backbone attached by hydrophilic poly(ethylene glycol) (PEG) side chains...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28296388/degradable-semiconducting-oligomer-amphiphile-for-ratiometric-photoacoustic-imaging-of-hypochlorite
#9
Chao Yin, Xu Zhen, Quli Fan, Wei Huang, Kanyi Pu
Upregulation of highly reactive oxygen species (ROS) such as hypochlorite (ClO-) is associated with many pathological conditions including cardiovascular diseases, neuron degeneration, lung injury and cancer. However, real-time imaging of ClO- is limited to the probes generally relying on fluorescence with shallow tissue-penetration depth. We here propose a self-assembly approach to develop activatable and degradable photoacoustic (PA) nanoprobes for in vivo imaging of ClO-. A near-infrared (NIR) absorbing amphiphilic oligomer was synthesized to undergo degradation in the presence of a specific ROS (ClO-), which integrates a π-conjugated but ClO- oxidizable backbone with hydrophilic PEG side chains...
March 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28293107/nh4hco3-gas-generating-liposomal-nanoparticle-for-photoacoustic-imaging-in-breast-cancer
#10
Jizhu Xia, Gang Feng, Xiaorong Xia, Lan Hao, Zhigang Wang
In this study, we have developed a biodegradable nanomaterial for photoacoustic imaging (PAI). Its biodegradation products can be fully eliminated from a living organism. It is a gas-generating nanoparticle of liposome-encapsulating ammonium bicarbonate (NH4HCO3) solution, which is safe, effective, inexpensive, and free of side effects. When lasers irradiate these nanoparticles, NH4HCO3 decomposes to produce CO2, which can absorb much of the light energy under laser irradiation with a specific wavelength, and then expand under heat to generate a thermal acoustic wave...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28290571/correction-nanoparticle-based-photoacoustic-analysis-for-highly-sensitive-lateral-flow-assays
#11
Yunfei Zhao, Yin Huang, Xiangwei Zhao, John F McClelland, Meng Lu
Correction for 'Nanoparticle-based photoacoustic analysis for highly sensitive lateral flow assays' by Yunfei Zhao et al., Nanoscale, 2016, 8, 19204-19210.
March 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28285157/near-infrared-light-responsive-nanoparticles-with-thermosensitive-yolk-shell-structure-for-multimodal-imaging-and-chemo-photothermal-therapy-of-tumor
#12
Song Shen, Bei Ding, Shengchang Zhang, Xueyong Qi, Kun Wang, Jie Tian, Yongsheng Yan, Yanru Ge, Lin Wu
Thermosensitive yolk-shell nanoparticles were developed as remote-controlled targeting drug delivery platform for multimodal imaging and combined therapy of cancer. The nanoparticles were fabricated using magnetic Fe3O4 nanoparticles as photothermal cores, thermo-responsive poly(N-isopropylacrylamide)-co-1-Vinyl-2-pyrrolidone p(NIPAM-co-NVP) as shells (Fe3O4-PNIPAM), with a hollow space between the two layers for loading of chemotherapeutic drug. The magnetic iron oxide nanoparticles cores could absorb and transform light to heat efficiently upon the irradiation of near infrared (NIR) laser, resulting in the shrink of the PNIPAM shell and the release of chemo-drugs...
March 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28285050/melanin-originated-carbonaceous-dots-for-triple-negative-breast-cancer-diagnosis-by-fluorescence-and-photoacoustic-dual-mode-imaging
#13
Wei Xiao, Yuan Li, Chuan Hu, Yuan Huang, Qin He, Huile Gao
Carbonaceous dots exhibit increasing applications in diagnosis and drug delivery due to excellent photostability and biocompatibility properties. However, relative short excitation and emission of melanin carbonaceous dots (MCDs) limit the applicability in fluorescence bioimaging. Furthermore, the generally poor spatial resolution of fluorescence imaging limits potential in vivo applications. Due to a variety of beneficial properties, in this study, MCDs were prepared exhibiting great potential in fluorescence and photoacoustic dual-mode bioimaging...
February 28, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28284105/surface-engineering-of-semiconducting-polymer-nanoparticles-for-amplified-photoacoustic-imaging
#14
Xu Zhen, Xiaohua Feng, Chen Xie, Yuanjin Zheng, Kanyi Pu
Despite the deeper tissue penetration of photoacoustic (PA) imaging, its sensitivity is generally lower than optical imaging. This fact partially restricts the applications of PA imaging and greatly stimulates the development of sensitive PA imaging agents. We herein report that the surface coating of semiconducting polymer nanoparticles (SPNs) with the silica layer can simultaneously amplify fluorescence and PA brightness while maintaining their photothermal conversion efficiency nearly unchanged. As compared with the bare SPNs, the silica-coated SPNs (SPNs-SiO2) have higher photothermal heating rate in the initial stage of laser irradiation due to the higher interfacial thermal conductance between the silica layer and water relative to that between the SP and water...
March 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28282636/texture-in-steel-plates-revealed-by-laser-ultrasonic-surface-acoustic-waves-velocity-dispersion-analysis
#15
Anmin Yin, Xiaochen Wang, Christ Glorieux, Quan Yang, Feng Dong, Fei He, Yanlong Wang, Jan Sermeus, Tom Van der Donck, Xuedao Shu
A photoacoustic, laser ultrasonics based approach in an Impulsive Stimulated Scattering (ISS) implementation was used to investigate the texture in polycrystalline metal plates. The angular dependence of the 'polycrystalline' surface acoustic wave (SAW) velocity measured along regions containing many grains was experimentally determined and compared with simulated results that were based on the angular dependence of the 'single grain' SAW velocity within single grains and the grain orientation distribution...
February 24, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28282469/correction-photoacoustic-imaging-of-cancer-treatment-response-early-detection-of-therapeutic-effect-from-thermosensitive-liposomes
#16
Jonathan P May, Eno Hysi, Lauren A Wirtzfeld, Elijus Undzys, Shyh-Dar Li, Michael C Kolios
[This corrects the article DOI: 10.1371/journal.pone.0165345.].
2017: PloS One
https://www.readbyqxmd.com/read/28278460/optoacoustic-dermoscopy-of-the-human-skin-tuning-excitation-energy-for-optimal-detection-bandwidth-with-fast-and-deep-imaging-in-vivo
#17
Mathias Schwarz, Dominik Soliman, Murad Omar, Andreas Buehler, Saak Ovsepyan, Juan Aguirre, Vasilis Ntziachristos
Optoacoustic (photoacoustic) dermoscopy offers two principal advantages over conventional optical imaging applied in dermatology. First, it yields high-resolution cross-sectional images of the skin at depths not accessible to other non-invasive optical imaging methods. Second, by resolving absorption spectra at multiple wavelengths, it enables label-free three-dimensional visualization of morphological and functional features. However, the relation of pulse energy to generated bandwidth and imaging depth remains poorly defined...
March 1, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28276544/advanced-optoacoustic-methods-for-multiscale-imaging-of-in-vivo-dynamics
#18
REVIEW
X L Deán-Ben, S Gottschalk, B Mc Larney, S Shoham, D Razansky
Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems...
March 9, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28275279/influence-of-laser-activated-irrigation-with-two-erbium-lasers-on-bond-strength-of-inidividually-formed-fiber-reinforced-composite-posts-to-root-canal-dentin
#19
Ivana Parčina, Amižić, Ivana Miletić, Andrei C Ionescu, Eugenio Brambilla, Dragana Gabrić, Anja Baraba
OBJECTIVE: The aim of this in vitro study was to investigate the effect of laser activated irrigation (LAI) using two erbium lasers on bond strength of individually formed fiber-reinforced composite (FRC) posts to root canal dentin. MATERIALS AND METHODS: Twenty-seven single-rooted human teeth were endodontically treated and after post space preparation divided into three groups (n=9 per group), according to the pre-treatment of post space preparation: 1) Conventional syringe irrigation (CSI) and saline; 2) Er...
December 2016: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28274767/copper-sulfide-nanoparticle-based-localized-drug-delivery-system-as-an-effective-cancer-synergistic-treatment-and-theranostic-platform
#20
Lin Hou, Xiaoning Shan, Lisha Hao, Qianhua Feng, Zhenzhong Zhang
Localized cancer treatment with combination therapy has attracted increasing attention for effective inhibition of tumor growth. In this work, we introduced diffusion molecular retention (DMR) tumor targeting effect, a new strategy that employed transferrin (Tf) modified hollow mesoporous CuS nanoparticles (HMCuS NPs) to undergo extensive diffuse through the interstitium and tumor retention after a peritumoral (PT) injection. Herein, HMCuS NPs with strong near-infrared (NIR) absorption and photothermal conversion efficiency could serve as not only a drug carrier but also a powerful contrast agent for photoacoustic imaging to guide chemo-phototherapy...
March 5, 2017: Acta Biomaterialia
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