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https://www.readbyqxmd.com/read/28633520/ion-selective-nanosensor-for-photoacoustic-and-fluorescence-imaging-of-potassium
#1
Chang Heon Lee, Jeff Folz, Wuliang Zhang, Janggun Jo, Joel W Y Tan, Xueding Wang, Raoul Kopelman
Ion-selective optodes (ISOs), the optical analog of ion-selective electrodes, have played an increasingly important role in chemical and biochemical analysis. Here we extend this technique to ion-selective photo-acoustic optodes (ISPAOs) that serve at the same time as fluorescence-based ISOs, and apply it specifically to potassium (K+). Notably, the potassium ion is one of the most abundant cations in biological systems, involved in numerous physiological and pathological processes. Furthermore, it has been recently reported that the presence of abnormal extracellular potassium concentrations in tumors suppresses the immune responses and thus suppresses immunotherapy...
June 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28631452/the-impact-of-the-anaesthetic-conserving-device-on-occupational-exposure-to-isoflurane-among-intensive-care-healthcare-professionals
#2
Jennifer Herzog-Niescery, Heike Vogelsang, Philipp Gude, Hans-Martin Seipp, Horst Bartz, Waldemar Uhl, Thomas P Weber, Martin Bellgardt
BACKGROUND: Use of Anesthetic Conserving Devices (ACD) for inhalational isoflurane sedation in intensive care units (ICU) has grown in recent years, and healthcare professionals are concerned about isoflurane pollution and exposure-related health risks. Real-time measurements to determine isoflurane exposure in ICU personnel during short-term patient care procedures and ACD handling have not yet been performed. METHODS: Isoflurane concentrations in the breathing zones of ICU staff (25 cm around the nose and mouth) were measured, by photoacoustic gas monitoring, during daily practice including tracheal suctioning, oral hygiene, body care, and patient positioning...
June 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28627734/role-of-cytoskeletal-mechanics-and-cell-membrane-fluidity-in-the-intracellular-delivery-of-molecules-mediated-by-laser-activated-carbon-nanoparticles
#3
Stefany Y Holguin, Caleb F Anderson, Naresh N Thadhani, Mark R Prausnitz
Exposure of cells and nanoparticles to near-infrared nanosecond pulsed laser light can lead to efficient intracellular delivery of molecules while maintaining high cell viability by a photoacoustic phenomenon known as transient nanoparticle energy transduction (TNET). Here, we examined the influence of cytoskeletal mechanics and plasma membrane fluidity on intracellular uptake of molecules and loss of cell viability due to TNET. We found that destabilization of actin filaments using latrunculin A led to greater uptake of molecules and less viability loss caused by TNET...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28618826/a-marchenko-equation-for-acoustic-inverse-source-problems
#4
Joost van der Neut, Jami L Johnson, Kasper van Wijk, Satyan Singh, Evert Slob, Kees Wapenaar
From acoustics to medical imaging and seismology, one strives to make inferences about the structure of complex media from acoustic wave observations. This study proposes a solution that is derived from the multidimensional Marchenko equation, to learn about the acoustic source distribution inside a volume, given a set of observations outside the volume. Traditionally, this problem has been solved by backpropagation of the recorded signals. However, to achieve accurate results through backpropagation, a detailed model of the medium should be known and observations should be collected along a boundary that completely encloses the volume of excitation...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28617354/photoacoustic-drug-delivery
#5
REVIEW
Yuqi Zhang, Jicheng Yu, Anna R Kahkoska, Zhen Gu
Photoacoustic (PA) technology holds great potential in clinical translation as a new non-invasive bioimaging modality. In contrast to conventional optical imaging, PA imaging (PAI) enables higher resolution imaging with deeper imaging depth. Besides applications for diagnosis, PA has also been extended to theranostic applications. The guidance of PAI facilitates remotely controlled drug delivery. This review focuses on the recent development of PAI-mediated drug delivery systems. We provide an overview of the design of different PAI agents for drug delivery...
June 15, 2017: Sensors
https://www.readbyqxmd.com/read/28614306/photoacoustic-confocal-dermoscope-with-a-waterless-coupling-and-impedance-matching-opto-sono-probe
#6
Haigang Ma, Sihua Yang, Zhongwen Cheng, Da Xing
Recently, intensive research on photoacoustic (PA) imaging has been conducted to accelerate the development of dermoscopy of the human skin. In this Letter, we first developed a PA dermoscope equipped with a waterless coupling and impedance matching opto-sono probe to achieve quantitative, high-resolution, and high-contrast imaging of the human skin. Compared with the commonly used liquid-coupled PA probes, the human-skin-adapted probe can facilitate implementation in the clinical setting. The noninvasive imaging experiments of epidermal and dermal structures in volunteers have been carried out to demonstrate the high imaging quality that can be obtained by using such an opto-sono probe for a PA dermoscope...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28613347/delineating-the-anatomy-of-the-ciliary-body-using-hybrid-optical-and-photoacoustic-imaging
#7
George J Tserevelakis, Stella Avtzi, Miltiadis K Tsilimbaris, Giannis Zacharakis
No abstract text is available yet for this article.
June 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28613167/a-light-illumination-enhancement-device-for-photoacoustic-imaging-i-in-vivo-i-animal-study
#8
Jaesok Yu, Joel S Schuman, Jung-Kun Lee, Sang Goo Lee, Jin Ho Chang, Kang Kim
Photoacoustic (PA) imaging detects acoustic signals generated by thermal expansion of light excited tissue or contrast agents. PA signal amplitude and image quality directly depend on the light fluence at the target depth. With conventional PA imaging systems, approximately 30% energy of incident light at the near-infrared region would be lost due to reflection on the skin surface. Such light loss directly leads to a reduction of PA signal and image quality. A new light delivery scheme that collects and re-distributes reflected light energy was recently suggested, which is called the light catcher...
June 8, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28611005/bottom-up-synthesis-of-ws2-nanosheets-with-synchronous-surface-modification-for-imaging-guided-tumor-regression
#9
Shige Wang, Jiulong Zhao, Hailun Yang, Chenyao Wu, Fei Hu, Haizhou Chang, Guixiang Li, Dan Ma, Duowu Zou, Mingxian Huang
Two-dimensional transition metal dichalcogenides (TMDs) have been receiving great attention as NIR photothermal transducing agent in tumor photothermal therapy. Keeping in mind the low efficiency of the conventional top-down exfoliation method to produce 2D TMDs and the complexity of their surface modifications, we herein proposed a bottom-up strategy for the one-pot and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS2 nanosheets, by hydrothermally treating the mixture solution of tetrathiotungstate and PVP...
June 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28608838/modifications-of-porphyrins-and-hydroporphyrins-for-their-solubilization-in-aqueous-media
#10
REVIEW
Michael Luciano, Christian Brückner
The increasing popularity of porphyrins and hydroporphyrins for use in a variety of biomedical (photodynamic therapy, fluorescence tagging and imaging, photoacoustic imaging) and technical (chemosensing, catalysis, light harvesting) applications is also associated with the growing number of methodologies that enable their solubilization in aqueous media. Natively, the vast majority of synthetic porphyrinic compounds are not water-soluble. Moreover, any water-solubility imposes several restrictions on the synthetic chemist on when to install solubilizing groups in the synthetic sequence, and how to isolate and purify these compounds...
June 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28605594/rational-design-of-branched-nanoporous-gold-nanoshells-with-enhanced-physico-optical-properties-for-optical-imaging-and-cancer-therapy
#11
Jibin Song, Xiangyu Yang, Zhen Yang, Lisen Lin, Yijing Liu, Zijian Zhou, Zheyu Shen, Guocan Yu, Yunlu Dai, Orit Jacobson, Jeeva Munasinghe, Bryant Yung, Gao-Jun Teng, Xiaoyuan Chen
Reported procedures on the synthesis of gold nanoshells with smooth surfaces have merely demonstrated efficient control of shell thickness and particle size, yet no branch and nanoporous features on the nanoshell have been implemented to date. Herein, we demonstrate the ability to control the roughness and nanoscale porosity of gold nanoshells by using redox-active polymer poly(vinylphenol)-b-(styrene) nanoparticles as reducing agent and template. The porosity and size of the branches on this branched nanoporous gold nanoshell (BAuNSP) material can be facilely adjusted by control of the reaction speed or the reaction time between the redox-active polymer nanoparticles and gold ions (Au(3+))...
June 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28603690/an-analytical-study-of-photoacoustic-and-thermoacoustic-generation-efficiency-towards-contrast-agent-and-film-design-optimization
#12
Fei Gao, Rahul Kishor, Xiaohua Feng, Siyu Liu, Ran Ding, Ruochong Zhang, Yuanjin Zheng
Photoacoustic (PA) and thermoacoustic (TA) effects have been explored in many applications, such as bio-imaging, laser-induced ultrasound generator, and sensitive electromagnetic (EM) wave film sensor. In this paper, we propose a compact analytical PA/TA generation model to incorporate EM, thermal and mechanical parameters, etc. From the derived analytical model, both intuitive predictions and quantitative simulations are performed. It shows that beyond the EM absorption improvement, there are many other physical parameters that deserve careful consideration when designing contrast agents or film composites, followed by simulation study...
September 2017: Photoacoustics
https://www.readbyqxmd.com/read/28601707/enhancement-of-biocompatibility-and-photoacoustic-contrast-activity-of-metal-clusters
#13
Arijit Bag, Pradip Kr Ghorai
Organometallic carbonyl clusters (OMCC) of group VIII elements are water soluble, bio-compatible and stable high-contrast photoacoustic agents for live cell imaging. But, they have limited application due to weak absorption within 700-1000nm wavelength which is known as the biological window of absorption. In this article, we report that hexa-nuclear iron (Fe6) carbonyl cluster derivatized with sodium thio-propanoate has very good absorption within 700-1600nm wave length. This modeled compound is water soluble and bio-compatible...
May 19, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28597608/advanced-photoacoustic-imaging-applications-of-near-infrared-absorbing-organic-nanoparticles
#14
REVIEW
Yuyan Jiang, Kanyi Pu
Progress of nanotechnology in recent years has stimulated fast development of nanoparticles in biomedical research. Photoacoustic (PA) imaging as an emerging non-invasive technique in molecular imaging has improved imaging depth relative to conventional optical imaging, demonstrating great potential in clinical applications. The convergence of nanotechnology and PA imaging has enabled a broad spectrum of new opportunities in fundamental biology and translation medicine. This review focuses on the recent advances of organic nanoparticles in PA imaging applications...
June 8, 2017: Small
https://www.readbyqxmd.com/read/28595014/a-chelator-free-and-biocompatible-melanin-nanoplatform-with-facile-loading-gadolinium-and-copper-64-for-bioimaging
#15
Su Hyun Hong, Yao Sun, Chu Tang, Kai Cheng, Ruiping Zhang, Quli Fan, Liying Xu, Daijuan Huang, Anthony Zhao, Zhen Cheng
Development of a chelator-free and biocompatible platform for facile construction of gadolinium3+ (Gd3+) loaded nanoparticle-based probe for in vivo magentic resonance imaging (MRI) is still challenging. Herein, a biocompatible Gd3+ loaded melanin dot (Gd-M-dot) has been easily preppared without the use of ay chelators, and the resulted nanoprobe exhibited good loading efficiency for Gd3+, high stability, and higher T1 relaxivity compared with the commercial contrast agent, Gd-DOTA. Furthermore, Gd-M-dot showed unique photoacoustic (PA) property, and high PA imaging signal could be observed after 1 h injection in small animal models...
June 8, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28593987/spaser-as-a-biological-probe
#16
Ekaterina I Galanzha, Robert Weingold, Dmitry A Nedosekin, Mustafa Sarimollaoglu, Jacqueline Nolan, Walter Harrington, Alexander S Kuchyanov, Roman G Parkhomenko, Fumiya Watanabe, Zeid Nima, Alexandru S Biris, Alexander I Plekhanov, Mark I Stockman, Vladimir P Zharov
Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28593942/dynamic-contrast-enhanced-photoacoustic-imaging-using-photothermal-stimuli-responsive-composite-nanomodulators
#17
Yun-Sheng Chen, Soon Joon Yoon, Wolfgang Frey, Mary Dockery, Stanislav Emelianov
Molecular photoacoustic imaging has shown great potential in medical applications; its sensitivity is normally in pico-to-micro-molar range, dependent on exogenous imaging agents. However, tissue can produce strong background signals, which mask the signals from the imaging agents, resulting in orders of magnitude sensitivity reduction. As such, an elaborate spectral scan is often required to spectrally un-mix the unwanted background signals. Here we show a new single-wavelength photoacoustic dynamic contrast-enhanced imaging technique by employing a stimuli-responsive contrast agent...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28593705/frequency-domain-analysis-of-multiwavelength-photoacoustic-signals-for-differentiating-among-malignant-benign-and-normal-thyroids-in-an-ex-vivo-study-with-human-thyroids
#18
Saugata Sinha, Vikram S Dogra, Bhargava K Chinni, Navalgund A Rao
OBJECTIVES: This study investigated the capability of spectral parameters, extracted by frequency domain analysis of photoacoustic signals, to differentiate among malignant, benign, and normal thyroid tissue. METHODS: We acquired multiwavelength photoacoustic images of freshly excised thyroid specimens collected from 50 patients who underwent thyroidectomy after having a diagnosis of suspected thyroid lesions. A thyroid cytopathologist marked histologic slides of each tissue specimen...
June 8, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28590721/biocompatible-iron-phthalocyanine-albumin-assemblies-as-photoacoustic-and-thermal-theranostics-in-living-mice
#19
Qingyan Jia, Jiechao Ge, Weimin Liu, Xiuli Zheng, Mengqi Wang, Hongyan Zhang, Pengfei Wang
Exploring novel and versatile nanomaterials for the construction of personalized multifunctional phototheranostics with significant potentials in bioimaging-guided tumor phototherapies has attracted considerable attention. Herein, the phototheranostic agent human serum albumin-iron (II) phthalocyanine FePc nanoparticles (HSA-FePc NPs) were fabricated for photoacoustic (PA) imaging-guided photothermal therapy (PTT) of cancer in vivo. The prepared HSA-FePc NPs exhibited high stability, efficient NIR absorption, good capability and stability of photothermal behavior with a high photothermal conversion efficiency of ∼44...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28586730/a-multifunctional-organosilica-cross-linker-for-the-bio-conjugation-of-gold-nanorods
#20
Sarah Lai, Sonia Centi, Claudia Borri, Fulvio Ratto, Lucia Cavigli, Filippo Micheletti, Bjӧrn Kemper, Steffi Ketelhut, Tatiana Kozyreva, Leonardo Gonnelli, Francesca Rossi, Stefano Colagrande, Roberto Pini
We report on the use of organosilica shells to couple gold nanorods to functional peptides and modulate their physiochemical and biological profiles. In particular, we focus on the case of cell penetrating peptides, which are used to load tumor-tropic macrophages and implement an innovative drug delivery system for photothermal and photoacoustic applications. The presence of organosilica exerts subtle effects on multiple parameters of the particles, including their size, shape, electrokinetic potential, photostability, kinetics of endocytic uptake and cytotoxicity, which are investigated by the interplay of colorimetric methods and digital holographic microscopy...
May 31, 2017: Colloids and Surfaces. B, Biointerfaces
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