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photoacoustic

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https://www.readbyqxmd.com/read/28726878/noninvasive-photoacoustic-measurement-of-glucose-by-data-fusion
#1
Ruochong Zhang, Fei Gao, Xiaohua Feng, Siyu Liu, Rahul Kishor, Yunqi Luo, Yuanjin Zheng
We proposed a novel noninvasive method for glucose detection using a photoacoustic (PA) technique utilizing both the peak-to-peak value and peak arrival time delay information. Without increasing apparatus and system complexity, we demonstrated the accuracy enhancement of 29.5% and 33.63% for high (0-7 g dL(-1)) and low (0-350 mg dL(-1)) concentration of glucose solution, compared to conventional amplitude-based prediction.
July 20, 2017: Analyst
https://www.readbyqxmd.com/read/28721041/high-intensity-focused-ultrasound-triggered-nanoscale-bubble-generating-liposomes-for-efficient-and-safe-tumor-ablation-under-photoacoustic-imaging-monitoring
#2
Gang Feng, Lan Hao, Chunyan Xu, Haitao Ran, Yuanyi Zheng, Pan Li, Yang Cao, Qi Wang, Jizhu Xia, Zhigang Wang
High-intensity focused ultrasound (HIFU) is widely applied to tumors in clinical practice due to its minimally invasive approach. However, several issues lower therapeutic efficiency in some cases. Many synergists such as microbubbles and perfluorocarbon nanoparticles have recently been used to improve HIFU treatment efficiency, but none were determined to be effective and safe in vivo. In this study, nanoscale bubble-generating liposomes (liposomes containing ammonium bicarbonate [Lip-ABC]) were prepared by film hydration followed by sequential extrusion...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28719818/insights-into-the-unique-functionality-of-inorganic-micro-nanoparticles-for-versatile-ultrasound-theranostics
#3
REVIEW
Xiaoqin Qian, Xiaoxia Han, Yu Chen
The clinical ultrasound (US)-based theranostic biomedicine suffers from the critical issue that traditional microbubbles (MBs) have lots of drawbacks such as low stability, large particle size, difficult structural control, etc. The unique composition, structure and functionality of inorganic micro/nanoplatforms have shown their great prospect for solving these critical issues and drawbacks of traditional organic MBs. This review summarizes and discusses the state-of-art development on exploring inorganic micro/nanoparticles for versatile US-based biomedical applications, ranging from US imaging, photoacoustic imaging, sonodynamic therapy, high intensity-focused US ablation and US-triggered chemotherapy...
July 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28717818/photoacoustic-imaging-using-genetically-encoded-reporters-a-review
#4
Joanna Brunker, Junjie Yao, Jan Laufer, Sarah E Bohndiek
No abstract text is available yet for this article.
July 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28717580/photoacoustic-ultrasound-dual-imaging-of-human-thyroid-cancers-an-initial-clinical-study
#5
Meng Yang, Lingyi Zhao, Xujin He, Na Su, ChenYang Zhao, Hewen Tang, Tao Hong, Wenbo Li, Fang Yang, Lin Lin, Bing Zhang, Rui Zhang, Yuxin Jiang, Changhui Li
We reported an initial clinical study of in vivo human thyroid by a photoacoustic/ultrasound handheld probe. Our dual-modality system is based on a high-end clinical ultrasound machine. Both healthy and cancerous thyroids were imaged non-invasively, and we compared the photoacoustic imaging with color Doppler ultrasound. The results of photoacoustic thyroid imaging could reveal many blood vessels that were not sensitive for Doppler ultrasound. Our study demonstrated that photoacoustic imaging could provide important complementary information for traditional ultrasound thyroid examination, which has a great potential for clinical diagnosis...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28714303/melittin-containing-hybrid-peptide-hydrogels-for-enhanced-photothermal-therapy-of-glioblastoma
#6
Honglin Jin, Guifang Zhao, Jianli Hu, Quanguang Ren, Kui Yang, Chao Wan, Ai Huang, Pindong Li, Jue-Ping Feng, Jing Chen, Zhenwei Zou
The design of biocompatible and efficacious anticancer biomaterials to achieve relatively low tumor recurrence rates is the main pursuit of cancer photothermal therapy (PTT). RADA 16-I is a synthetic amphiphilic peptide with the sequence RADARADARADARADA that can self-assemble into a peptide nanofiber hydrogel. In this study, we synthesized a novel Melittin-RADA32-Indocyanine green (ICG) hydrogel ("MRI hydrogel"), which contains melittin in the peptide hydrogel backbone and ICG in the hydrogel matrix, for enhanced PTT of glioblastomas...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28709019/biocompatible-pegylated-bismuth-nanocrystals-all-in-one-theranostic-agent-with-triple-modal-imaging-and-efficient-in%C3%A2-vivo-photothermal-ablation-of-tumors
#7
Zhenglin Li, Jing Liu, Ying Hu, Zhuo Li, Xuelei Fan, Ye Sun, Flemming Besenbacher, Chunying Chen, Miao Yu
Biocompatible single-component theranostic agents integrating multimodal imaging and therapeutic functions (namely, "all-in one" agents) are highly desired for clinical cancer treatments. Herein, PEGylated pure metallic bismuth nanocrystals (Bi-PEG NCs) have been developed to be a competent theranostic agent for in vivo high-performance multimodal bio-imaging and photothermal ablation of tumors. The resultant Bi-PEG NCs show excellent physiological stability, biocompatibility, prolonged blood circulation half-life and preferential tumor accumulation...
June 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28708389/nanostructured-phthalocyanine-assemblies-with-protein-driven-switchable-photoactivities-for-biophotonic-imaging-and-therapy
#8
Xingshu Li, C-Yoon Kim, Seunghyun Lee, Dayoung Lee, Hyung Min Chung, Gyoungmi Kim, Si-Hyun Heo, Chulhong Kim, Ki-Sung Hong, Juyoung Yoon
Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine. Here, we develop a "one-for-all" nanomaterial that self-assembles from flexible and versatile phthalocyanine building blocks. The nanostructured phthalocyanine assemblies (NanoPcTBs) display intrinsically unique photothermal and photoacoustic properties. Fluorescence and reactive oxygen species (ROS) generation can be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy (PDT)...
July 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28708251/efficacy-of-photon-initiated-photoacoustic-streaming-on-apically-extruded-debris-with-different-preparation-systems-in-curved-canals
#9
D Arslan, A Kustarci
AIM: To determine the effect of photon-initiated photoacoustic streaming (PIPS) on the extrusion of debris using multiple-file (ProTaper Next-PTN) and single-file (One Shape-OS) continuous rotary systems in curved canals in human molar teeth. METHODOLOGY: Sixty extracted maxillary first molar teeth with curved mesial roots, mature apices and of similar lengths were selected. Teeth with apical diameters larger than size 15 were discarded. The teeth were randomly divided into 4 experimental groups (n=15 teeth per group) according to the file used and irrigation systems: (1) OS with PIPS with a 2940 nm Er:YAG laser (0...
July 14, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28703340/core-satellite-polydopamine-gadolinium-metallofullerene-nanotheranostics-for-multimodal-imaging-guided-combination-cancer-therapy
#10
Sheng Wang, Jing Lin, Zhantong Wang, Zijian Zhou, Ruiliang Bai, Nan Lu, Yijing Liu, Xiao Fu, Orit Jacobson, Wenpei Fan, Junle Qu, Siping Chen, Tianfu Wang, Peng Huang, Xiaoyuan Chen
Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-(64) Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy...
July 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28703256/can-photoacoustic-imaging-quantify-surface-localized-j-aggregating-nanoparticles
#11
Liang Lim, Robert Mastragostino, Kenneth Ng, Gang Zheng, Brian C Wilson
No abstract text is available yet for this article.
July 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28702902/oxygenation-status-in-chronic-leg-ulcer-after-topical-hemoglobin-application-may-act-as-a-surrogate-marker-to-find-the-best-treatment-strategy-and-to-avoid-ineffective-conservative-long-term-therapy
#12
Maximilian Petri, Ingo Stoffels, Klaus Griewank, Jithin Jose, Peter Engels, Andrea Schulz, Harald Pötzschke, Philipp Jansen, Dirk Schadendorf, Joachim Dissemond, Joachim Klode
PURPOSE: Chronic leg ulcers can be a challenge to treat and long-term therapy a significant cost factor in western public health budgets. Objective wound assessment assays enabling selection of appropriate wound therapy regimes would be desirable. Oxygenation status in ulcer tissue has obtained increased attention as a relevant factor in wound healing. To increase oxygenation in wounds, a topical hemoglobin spray was developed. Although favorable results have been noted, the link between clinical efficacy and the mode of action has not been demonstrated...
July 12, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28702357/a-numerical-analysis-of-a-semi-dry-coupling-configuration-in-photoacoustic-computed-tomography-for-infant-brain-imaging
#13
Najme Meimani, Nina Abani, Juri Gelovani, Mohammad R N Avanaki
In the application of photoacoustic human infant brain imaging, debubbled ultrasound gel or water is commonly used as a couplant for ultrasonic transducers due to their acoustic properties. The main challenge in using such a couplant is its discomfort for the patient. In this study, we explore the feasibility of a semi-dry coupling configuration to be used in photoacoustic computed tomography (PACT) systems. The coupling system includes an inflatable container consisting of a thin layer of Aqualene with ultrasound gel or water inside of it...
September 2017: Photoacoustics
https://www.readbyqxmd.com/read/28701743/precise-detection-of-circular-dichroism-in-a-cluster-of-nano-helices-by-photoacoustic-measurements
#14
Alessio Benedetti, Badrul Alam, Marco Esposito, Vittorianna Tasco, Grigore Leahu, Alessandro Belardini, Roberto Li Voti, Adriana Passaseo, Concita Sibilia
Compact samples of nano-helices built by means of a focused ion beam technology with large bandwidth and high dichroism for circular polarization are promising for the construction of built-in-chip sensors, where the ideal transducer must be sufficiently confined without compromising its filtering ability. Direct all-optical measurements revealed the sample's dichroic character with insufficient details because of scattering and diffraction interference. On the other hand, photoacoustic measurements resulted to be a possible alternative investigation, since they directly deal with absorbed power and allow to get clear evidences of the differential selection for the two opposite polarization states...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700822/laser-desorption-postionization-mass-spectrometry-imaging-of-folic-acid-molecules-in-tumor-tissue
#15
Qiao Lu, Yongjun Hu, Jiaxin Chen, Shan Jin
Mass spectrometry imaging (MSI) is an innovative and powerful tool in biomedical research. It is well known that folic acid (FA) has a high affinity for folic acid receptor (FR) which is overexpressing in epithelial cancer. Herein, we propose a novel method to diagnose cancer through direct mapping of the label-free FA spatial distribution in tissue sections by state-of-the-art laser desorption postionization mass spectrometry imaging (LDPI-MSI). Compared with other tumor imaging methods, such as fluorescence imaging, photoacoustic imaging (PAI), magnetic resonance imaging (MRI) and micro-SPECT/CT, complicated synthesis and labeling processes are not required...
July 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28700132/non-invasive-sentinel-lymph-node-mapping-and-needle-guidance-using-clinical-handheld-photoacoustic-imaging-system-in-small-animal
#16
Kathyayini Sivasubramanian, Vijitha Periyasamy, Manojit Pramanik
Translating photoacoustic imaging into clinical setup is a challenge. Handheld clinical real-time photoacoustic imaging systems are not common. In this work, we report an integrated photoacoustic and clinical ultrasound imaging system by combining light delivery with the ultrasound probe for sentinel lymph node imaging and needle guidance in small animal. The open access clinical ultrasound platform allows seamless integration of photoacoustic imaging resulting in the development of handheld real-time photoacoustic imaging probe...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28697234/development-of-low-cost-photoacoustic-imaging-systems-using-very-low-energy-pulsed-laser-diodes
#17
Ali Hariri, Afreen Fatima, Nafiseh Mohammadian, Sadreddin Mahmoodkalayeh, Mohammad Ali Ansari, Nicholas Bely, Mohammad R N Avanaki
No abstract text is available yet for this article.
July 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28696454/a-cation-exchange-controlled-core-shell-mns-bi2s3-theranostic-platform-for-multimodal-imaging-guided-radiation-therapy-with-hyperthermia-boost
#18
Yuhao Li, Yun Sun, Tianye Cao, Qianqian Su, Zili Li, Mingxian Huang, Ruizhuo Ouyang, Haizhou Chang, Shuping Zhang, Yuqing Miao
Overtreatment as a crucial modern medicine issue needs to be urgently addressed. Theranostic agents supply a unique platform and integrate multiple diagnosis and therapies to deal with this issue. In this study, a core-shell MnS@Bi2S3 nanostructure was fabricated via two step reactions for tri-modal imaging guided thermo-radio synergistic therapy. The mass ratio between the core and shell of the constructed MnS@Bi2S3 can be precisely controlled via cation exchange reaction. After surface PEGylation, MnS@Bi2S3-PEG nanoparticles exhibited excellent aqueous medium dispersibility for bioapplications...
July 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28692799/highly-stable-organic-small-molecular-nanoparticles-as-an-advanced-and-biocompatible-phototheranostic-agent-of-tumor-in-living-mice
#19
Ji Qi, Yuan Fang, Ryan T K Kwok, Xiaoyan Zhang, Xianglong Hu, Jacky W Y Lam, Dan Ding, Ben Zhong Tang
Near-infrared (NIR)-absorbing organic small molecules hold great promise as the phototheranostic agents for clinical translation by virtue of their intrinsic advantages such as well-defined chemical structure, high purity, and good reproducibility. However, most of the currently available ones face the challenges in varying degrees in terms of photothermal instability, and photobleaching/reactive oxygen nitrogen species (RONS) inresistance, which indeed impair their practical applications in precise diagnosis and treatment of diseases...
July 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28692724/toroidal-sensor-arrays-for-real-time-photoacoustic-imaging
#20
Anton S Bychkov, Elena B Cherepetskaya, Alexander A Karabutov, Vladimir A Makarov
No abstract text is available yet for this article.
July 1, 2017: Journal of Biomedical Optics
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