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https://www.readbyqxmd.com/read/28444151/photoacoustic-imaging-probe-for-detecting-lymph-nodes-and-spreading-of-cancer-at-various-depths
#1
Yong-Jae Lee, Eun-Ju Jeong, Hyun-Woo Song, Chang-Geun Ahn, Hyung Wook Noh, Joo Yong Sim, Dong Hoon Song, Min Yong Jeon, Susung Lee, Heewon Kim, Meihua Zhang, Bong Kyu Kim
No abstract text is available yet for this article.
September 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28441473/assembly-of-macrocycle-dye-derivatives-into-particles-for-fluorescence-and-photoacoustic-applications
#2
Hoang Dung Lu, Tristan L Lim, Shoshana Javitt, Andrew Heinmiller, Robert K Prud'homme
Optical imaging is a rapidly progressing medical technique that can benefit from the development of new and improved optical imaging agents suitable for use in vivo. However, the molecular rules detailing what optical agents can be processed and encapsulated into in vivo presentable forms are not known. We here present the screening of series of highly hydrophobic porphyrin, phthalocyanine, and naphthalocyanine dye macrocycles through a self-assembling Flash NanoPrecipitation process to form a series of water dispersible dye nanoparticles (NPs)...
April 25, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28437194/comparison-of-three-final-irrigation-activation-techniques-effects-on-canal-cleanness-smear-layer-removal-and-dentinal-tubule-penetration-of-two-root-canal-sealers
#3
Elmas Turkel, Emel Olga Onay, Mete Ungor
OBJECTIVE: The aim of this study was to compare three final irrigation activation techniques with respect to their effects on debridement efficacy, smear layer removal, and dentinal tubule penetration of two different root canal sealers. BACKGROUND DATA: Different applications to improve the delivery of irrigating solutions within the root canal system are currently being investigated, as not all of the mechanisms and effects of these techniques have been clearly identified...
February 22, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28436857/real-time-triple-modal-photoacoustic-ultrasound-and-magnetic-resonance-fusion-imaging-of-humans
#4
Sara Park, Jongseong Jang, Jeesu Kim, Young Soo Kim, Chulhong Kim
Imaging that fuses multiple modes has become a useful tool for diagnosis and therapeutic monitoring. As a next step, real-time fusion imaging has attracted interest as for a tool to guide surgery. One widespread fusion imaging technique in surgery combines real-time ultrasound (US) imaging and preacquired magnetic resonance (MR) imaging. However, US imaging visualizes only structural information with relatively low contrast. Here, we present a photoacoustic (PA), US, and MR fusion imaging system which integrates a clinical PA and US imaging system with an optical tracking-based navigation subsystem...
April 24, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28426292/efficacy-of-three-different-lasers-on-eradication-of-enterococcus-faecalis-and-candida-albicans-biofilms-in-root-canal-system
#5
Silvija Kasić, Marita Knezović, Nataša Beader, Dragana Gabrić, Ana Ivanišević Malčić, Anja Baraba
OBJECTIVE: The objective was to compare the efficacy of three different lasers in disinfection of root canals inoculated with Enterococcus faecalis and Candida albicans biofilms. BACKGROUND: Endodontic space disinfection depends on the type of root canal irrigant used and the way it is delivered and agitated because irrigants have limited ability to reach all parts of root canal system. MATERIALS AND METHODS: Thirty single-rooted human teeth were selected...
April 20, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28426202/chemical-design-and-synthesis-of-functionalized-probes-for-imaging-and-treating-tumor-hypoxia
#6
Jia-Nan Liu, Wenbo Bu, Jianlin Shi
Hypoxia development in tumor is closely associated with its increased aggressiveness and strong resistance to therapy, leading to the poor prognosis in several cancer types. Clinically, invasive oxygen microelectrode and high dosage radiotherapy are often utilized to accurately detect and effectively fight hypoxia. Recently, however, there has been a surge of interdisciplinary research aiming at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors...
April 20, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28418679/bioresponsive-polyoxometalate-cluster-for-redox-activated-photoacoustic-imaging-guided-photothermal-cancer-therapy
#7
Dalong Ni, Dawei Jiang, Hector F Valdovinos, Emily B Ehlerding, Bo Yu, Todd E Barnhart, Peng Huang, Weibo Cai
Although various types of imaging agents have been developed for photoacoustic (PA) imaging, relatively few imaging agents exhibit high selectivity/sensitivity to the tumor microenvironment for on-demand PA imaging and therapy. Herein, molybdenum-based polyoxometalate (POM) clusters with the highest oxidation state of Mo(VI) (denoted as Ox-POM) were designed as novel agents for redox-activated PA imaging-guided photothermal therapy. Capable of escaping from recognition and capture by the liver and spleen, these renal clearable clusters with ultrasmall size (hydrodynamic size: 1...
April 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28417584/ir-spectroscopy-of-skin-in%C3%A2-vivo-optimal-skin-sites-and-properties-for-non-invasive-glucose-measurement-by-photoacoustic-and-photothermal-spectroscopy
#8
Alexander Bauer, Otto Hertzberg, Arne Küderle, Dominik Strobel, Miguel A Pleitez, Werner Mäntele
We have reported two methods to analyze glucose in the interstitial fluid of skin based on mid-infrared excitation with a tunable quantum cascade laser and photoacoustic or photothermal detection. These methods were evaluated for optimum skin locations to obtain reproducible glucose information. The lower part of the arm, the hypothenar, the tips of the index finger and the thumb were tested. The thumb appears to be the optimal skin location, followed by the index finger. Basic requirements for an optimum site are good capillary blood perfusion, low Stratum corneum thickness and the absence of fat layers...
April 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28417485/tumor-microenvironment-triggered-supramolecular-system-as-an-in-situ-nanotheranostic-generator-for-cancer-phototherapy
#9
Chengchao Chu, Huirong Lin, Heng Liu, Xiaoyong Wang, Junqing Wang, Pengfei Zhang, Haiyan Gao, Chao Huang, Yun Zeng, Yuanzhi Tan, Gang Liu, Xiaoyuan Chen
The efficacy of photosensitizers in cancer phototherapy is often limited by photobleaching, low tumor selectivity, and tumor hypoxia. Assembling photosensitizers into nanostructures can improve photodynamic therapy efficacy and the safety profile of photosensitizers. Herein by employing supramolecular assembly, enhanced theranostic capability of Mn(2+) -assisted assembly of a photosensitizer (sinoporphyrin sodium, DVDMS) is demonstrated. A tumor environment-triggered coassembly strategy is further developed to form Mn/DVDMS nanotheranostics (nanoDVD) for cancer phototherapy...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28417068/photoacoustic-in-vitro-flow-cytometry-for-nanomaterial-research
#10
Dmitry A Nedosekin, Tariq Fahmi, Zeid A Nima, Jacqueline Nolan, Chengzhong Cai, Mustafa Sarimollaoglu, Enkeleda Dervishi, Alexei Basnakian, Alexandru S Biris, Vladimir P Zharov
Conventional flow cytometry is a versatile tool for drug research and cell characterization. However, it is poorly suited for quantification of non-fluorescent proteins and artificial nanomaterials without the use of additional labeling. The rapid growth of biomedical applications for small non-fluorescent nanoparticles (NPs) for drug delivery and contrast and therapy enhancement, as well as research focused on natural cell pigments and chromophores, demands high-throughput quantification methods for the non-fluorescent components...
June 2017: Photoacoustics
https://www.readbyqxmd.com/read/28417067/quantitative-photoacoustic-integrating-sphere-qpais-platform-for-absorption-coefficient-and-gr%C3%A3-neisen-parameter-measurements-demonstration-with-human-blood
#11
Yolanda Villanueva-Palero, Erwin Hondebrink, Wilma Petersen, Wiendelt Steenbergen
Quantitative photoacoustic imaging in biomedicine relies on accurate measurements of relevant material properties of target absorbers. Here, we present a method for simultaneous measurements of the absorption coefficient and Grüneisen parameter of small volume of liquid scattering and absorbing media using a coupled-integrating sphere system which we refer to as quantitative photoacoustic integrating sphere (QPAIS) platform. The derived equations do not require absolute magnitudes of optical energy and pressure values, only calibration of the setup using aqueous ink dilutions is necessary...
June 2017: Photoacoustics
https://www.readbyqxmd.com/read/28411450/activatable-near-infrared-dye-conjugated-hyaluronic-acid-based-nanoparticles-as-a-targeted-theranostic-agent-for-enhanced-fluorescence-ct-photoacoustic-imaging-guided-photothermal-therapy
#12
Xiaolong Liang, Lei Fang, Xiaoda Li, Xu Zhang, Fan Wang
Targeted theranostic nano-system integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully designed and fabricated, and simultaneously used as a carrier for encapsulating perfluorooctylbromide (PFOB). In this system, PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as a fluorescent dye activatable by hyaluronidases (Hyals) in the tumor, and IR825 in the core as a photothermal agent...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28407493/plasmonic-titanium-nitride-nanoparticles-for-in%C3%A2-vivo-photoacoustic-tomography-imaging-and-photothermal-cancer-therapy
#13
Wenya He, Kelong Ai, Chunhuan Jiang, Yuanyuan Li, Xiangfu Song, Lehui Lu
Titanium nitride, an alternative plasmonic material to gold with unique physiochemical properties, has been widely used in microelectronics, biomedical devices and food-contact applications. However, its potential application in the area of biomedicine has not been effectively explored. With the spectral match of their plasmon resonance band and the biological transparency window as well as good biocompatibility, titanium nitride nanoparticles (TiN NPs) are promising photoabsorbing agents for photothermal therapy (PTT) and photoacoustic imaging...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28407403/water-soluble-n-heterocyclic-carbene-protected-gold-nanoparticles-size-controlled-synthesis-stability-and-optical-properties
#14
Kirsi Salorinne, Renee W Y Man, Chien-Hung Li, Masayasu Taki, Masakazu Nambo, Cathleen M Crudden
NHC-Au(I) complexes were used to prepare stable, water-soluble, NHC-protected gold nanoparticles. The water-soluble, charged nature of the nanoparticles permitted analysis by polyacrylamide gel electrophoresis (PAGE), which showed that the nanoparticles were highly monodisperse, with tunable core diameters between 2.0 and 3.3 nm depending on the synthesis conditions. Temporal, thermal, and chemical stability of the nanoparticles were determined to be high. Treatment with thiols caused etching of the particles after 24 h; however larger plasmonic particles showed greater resistance to thiol treatment...
April 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28405657/a-triple-synergistic-strategy-for-combinational-photo-radiotherapy-and-multi-modality-imaging-based-on-hyaluronic-acid-hybridized-polyaniline-coated-ws2-nanodots
#15
Jinping Wang, Xiaojuan Pang, Xiaoxiao Tan, Yilin Song, Li Liu, Qing You, Qi Sun, Fengping Tan, Nan Li
In this study, we report a strategy for integrating hyaluronic acid (HA), polyaniline (PANI), WS2 nanodots (WS2), and chlorin e6 (Ce6) into a single nanoplatform (HA-WS2@PANI/Ce6) for fluorescence, photoacoustic, and computed tomography multi-modality imaging-guided trimodal photothermal/radiation/photodynamic combination therapy of tumors. The WS2 nanodot core is used as the radiosensitizer with the PANI shell as the hyperthermal agent and the photosensitizer reservoir. HA and Ce6 were adsorbed on the outer shell for tumor targeting and photodynamic therapy, respectively...
April 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28401627/development-of-semiconducting-polymer-nanoparticles-for-photoacoustic-imaging
#16
REVIEW
Dong Cui, Chen Xie, Kanyi Pu
Semiconducting polymer nanoparticles (SPNs) have evolved into a new class of photonic materials with great potential for biomedical applications. Depending on the polymer structures, SPNs can be developed into optical agents for fluorescence and chemiluminescence imaging, photosensitizers for photodynamic therapy, and heat converters for photothermal therapy. In this feature article, recent work is summarized on the development of SPNs for in vivo photoacoustic (PA) imaging, a state-of-the-art imaging modality that converts light energy into mechanical acoustic waves to provide deep tissue penetration...
April 12, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28397761/synergetic-resonance-matching-of-a-microphone-and-a-photoacoustic-cell
#17
Joo Yong Sim, Chang-Geun Ahn, Chul Huh, Kwang Hyo Chung, Eun-Ju Jeong, Bong Kyu Kim
We propose an approach to match the resonant characteristics of a photoacoustic cell with that of a microphone in order to enhance the signal-to-noise ratio in the photoacoustic sensor system. The synergetic resonance matching of a photoacoustic cell and a microphone was achieved by observing that photoacoustic cell resonance is merged with microphone resonance, in addition to conducting numerical and analytical simulations. Using this approach, we show that the signal-to-noise ratio was increased 3.5-fold from the optimized to non-optimized cell in the photoacoustic spectroscopy system...
April 8, 2017: Sensors
https://www.readbyqxmd.com/read/28395135/ultrasmall-semimetal-nanoparticles-of-bismuth-for-dual-modal-computed-tomography-photoacoustic-imaging-and-synergistic-thermoradiotherapy
#18
Xujiang Yu, Ang Li, Chengzhi Zhao, Kai Yang, Xiaoyuan Chen, Wanwan Li
Multifunctional nanomaterials with integrated diagnostic and therapeutic functions, combination therapy to enhance treatment efficacy, as well as low toxicity have drawn tremendous attentions. Herein, we report a multifunctional theranostic agent based on peptide (LyP-1)-labeled ultrasmall semimetal nanoparticles of bismuth (Bi-LyP-1 NPs). Ultrasmall Bi NPs (3.6 nm) were facilely synthesized using oleylamine as the reducing agent and exhibited a higher tumor accumulation after being conjugated with the tumor-homing peptide LyP-1...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28394000/listening-to-membrane-potential-photoacoustic-voltage-sensitive-dye-recording
#19
Haichong K Zhang, Ping Yan, Jeeun Kang, Diane S Abou, Hanh N D Le, Abhinav K Jha, Daniel L J Thorek, Jin U Kang, Arman Rahmim, Dean F Wong, Emad M Boctor, Leslie M Loew
No abstract text is available yet for this article.
April 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28393130/oxidation-responsive-eu-ii-iii-based-multimodal-contrast-agent-for-magnetic-resonance-and-photoacoustic-imaging
#20
Lina A Basal, Yan Yan, Yimin Shen, E Mark Haacke, Mohammad Mehrmohammadi, Matthew J Allen
We report, for the first time, a multimodal, oxidation-responsive contrast agent for magnetic resonance imaging and photoacoustic imaging that uses the differences in the properties between Eu in the +2 and +3 oxidation states. The enhancement of contrast in T1-weighted magnetic resonance and photoacoustic imaging was observed in the +2 but not in the +3 oxidation state, and the complex is a known chemical exchange saturation transfer agent for magnetic resonance imaging in the +3 oxidation state.
March 31, 2017: ACS Omega
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