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https://www.readbyqxmd.com/read/28336394/ts1cje-down-syndrome-model-mice-exhibit-environmental-stimuli-triggered-locomotor-hyperactivity-and-sociability-concurrent-with-increased-flux-through-central-dopamine-and-serotonin-metabolism
#1
Atsushi Shimohata, Keiichi Ishihara, Satoko Hattori, Hiroyuki Miyamoto, Hiromasa Morishita, Guy Ornthanalai, Matthieu Raveau, Abdul Shukkur Ebrahim, Kenji Amano, Kazuyuki Yamada, Haruhiko Sago, Satoshi Akiba, Nobuko Mataga, Niall P Murphy, Tsuyoshi Miyakawa, Kazuhiro Yamakawa
Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice...
March 20, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28331551/environmental-costs-and-benefits-of-growing-miscanthus-for-bioenergy-in-the-uk
#2
REVIEW
Jon P McCalmont, Astley Hastings, Niall P McNamara, Goetz M Richter, Paul Robson, Iain S Donnison, John Clifton-Brown
Planting the perennial biomass crop Miscanthus in the UK could offset 2-13 Mt oil eq. yr(-1), contributing up to 10% of current energy use. Policymakers need assurance that upscaling Miscanthus production can be performed sustainably without negatively impacting essential food production or the wider environment. This study reviews a large body of Miscanthus relevant literature into concise summary statements. Perennial Miscanthus has energy output/input ratios 10 times higher (47.3 ± 2.2) than annual crops used for energy (4...
March 2017: Global Change Biology. Bioenergy
https://www.readbyqxmd.com/read/28328273/the-origins-of-a-two-tier-profession-a-nursing-school-at-a-poor-law-infirmary
#3
Niall McCrae, Katerina Kuzminska
Niall McCrae, Lecturer, and Katerina Kuzminska, Postgraduate Nursing Student, Florence Nightingale Faculty of Nursing and Midwifery, King's College, London, chart the influences of Nightingale's Poor Law infirmary reforms.
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28326344/osteogenic-stem-cell-selection-for-repair-and-regeneration
#4
Marcus Tillotson, Niall Logan, Peter Brett
The first osteogenic cells to attach to a titanium (Ti) implant after placement are the multipotent stromal cells (MSCs) that circulate in the bloodstream and are recruited to the site of tissue damage. The reservoirs of these cells are heterogeneous in nature, consisting of a mixture of cells with varying differentiation abilities. In order to utilise these cells and to reduce the chance of unwanted events during regenerative therapies, the selection of a subset of cells that is truly multipotent is required...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28324663/trappist-1-the-dawning-of-the-age-of-aquarius%C3%A2
#5
Roy D Sleator, Niall Smith
No abstract text is available yet for this article.
March 21, 2017: Bioengineered
https://www.readbyqxmd.com/read/28324203/adult-acquired-flatfoot-deformity
#6
REVIEW
Niall A Smyth, Amiethab A Aiyer, Jonathan R Kaplan, Clayton A Carmody, Anish R Kadakia
Adult-acquired flatfoot deformity (AAFD) is a known and recognized cause of pain and disability. Loss of PTT function is the most important contributor to AAFD, and its estimated prevalence is thought to be over 3%. This review aims to summarize the current literature and encompass recent advances regarding AAFD.
March 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28323656/tumor-margin-assessment-with-loupe-magnification-enables-greater-histological-clearance-of-facial-basal-cell-carcinomas-compared-with-clinical-examination-alone
#7
Conor M Sugrue, Niall McInerney, Cormac W Joyce, Jack L Kelly
BACKGROUND: Surgical excision of facial basal cell carcinomas (BCCs) is a balance between oncological clearance and conservation of cosmetic and functionally sensitive tissues. OBJECTIVE: To assess if loupe magnification (LM) can enhance the visual assessment of BCC tumor margins resulting in a greater histological clearance. METHODS AND MATERIALS: This prospective study randomized patients with primary facial BCCs into preoperative tumor margin assessment with LM (study group) or clinical examination alone (control group)...
March 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28322552/one-step-fabrication-of-a-microfluidic-device-with-an-integrated-membrane-and-embedded-reagents-by-multimaterial-3d-printing
#8
Feng Li, Petr Smejkal, Niall P Macdonald, Rosanne M Guijt, Michael C Breadmore
One of the largest impediments in the development of microfluidic-based smart sensing systems is the manufacturability of integrated, complex devices. Here, we propose multimaterial 3D printing for the fabrication of such devices in a single step. A microfluidic device containing an integrated porous membrane and embedded liquid reagents was made by 3D printing and applied for the analysis of nitrate from soil. The manufacture of the integrated, sealed device was realised as a single print within 30 min. The body of the device was printed in transparent acrylonitrile butadiene styrene (ABS), and contained a 400 μm wide structure printed from a commercially available composite filament...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28319372/3d-printed-micrometre-scale-polymer-mounts-for-single-crystal-analysis
#9
Niall P Macdonald, Grace L Bunton, Ah Young Park, Michael C Breadmore, Nathan Laird Kilah
3D printed micrometre-scale polymer mounts for single crystal analysis have been prepared by photo polymerization using digital light projection stereolithography (DLP-SLA), with a commercially available digital light projection stereolithography printer (US$4000) and 3DM-ABS resin (US$150 per litre). The polymer mounts were prepared in batches of 49 in 1 hour 15 minutes, which allowed for rapid prototyping and testing of new crystal mounting designs, with a resin cost of 0.2¢ US per mount. The suitability of the 3D printed mounts for single crystal crystallography has been demonstrated through their use in Cu Kα X-ray diffraction experiments of Rochelle salt (sodium potassium tartrate), the protein lysozyme, and has been employed for routine crystallographic analysis of organic and inorganic materials...
March 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28319031/evaluation-of-the-water-equivalence-of-plastic-materials-in-low-and-high-energy-clinical-proton-beams
#10
Ana Lourenco, David Shipley, Nigel Wellock, Russell Thomas, Hugo Bouchard, Andrzej Kacperek, Francesco Fracchiolla, Stefano Lorentini, Marco Schwarz, Niall MacDougall, Gary Royle, Hugo Palmans
The aim of this work was to evaluate the water-equivalence of new trial plastics designed specifically for light-ion beam dosimetry as well as commercially available plastics in clinical proton beams. The water-equivalence of materials was tested by computing a plastic-to-water conversion factor, <i>H</i><sub><i>pl</i>,w</sub>. Trial materials were characterized experimentally in 60 MeV and 226 MeV un-modulated proton beams and the results were compared with Monte Carlo simulations using the FLUKA code...
March 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28301457/exploring-the-feasibility-of-delivering-standardized-genomic-care-using-ophthalmology-as-an-example
#11
Niall Davison, Katherine Payne, Martin Eden, Marion McAllister, Stephen A Roberts, Stuart Ingram, Graeme C M Black, Georgina Hall
PURPOSE: Broadening access to genomic testing and counseling will be necessary to realize the benefits of personalized health care. This study aimed to assess the feasibility of delivering a standardized genomic care model for inherited retinal dystrophy (IRD) and of using selected measures to quantify its impact on patients. METHODS: A pre-/post- prospective cohort study recruited 98 patients affected by IRD to receive standardized multidisciplinary care. A checklist was used to assess the fidelity of the care process...
March 16, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28298719/two-consultant-spinal-operating-operator-perceived-benefits
#12
Jonathan Macdonald, Stacey Thomson, Niall Eames, Greg McLorinan, Eugene Verzin, Nagy Darwish
No abstract text is available yet for this article.
January 2017: Ulster Medical Journal
https://www.readbyqxmd.com/read/28281349/comparing-microfluidic-performance-of-three-dimensional-3d-printing-platforms
#13
Niall P Macdonald, Joan M Cabot, Petr Smejkal, Rosanne M Guijt, Brett Paull, Michael C Breadmore
Three-dimensional (3D) printing has emerged as a potential revolutionary technology for the fabrication of microfluidic devices. A direct experimental comparison of the three 3D printing technologies dominating microfluidics was conducted using a Y-junction microfluidic device, the design of which was optimized for each printer: fused deposition molding (FDM), Polyjet, and digital light processing stereolithography (DLP-SLA). Printer performance was evaluated in terms of feature size, accuracy, and suitability for mass manufacturing; laminar flow was studied to assess their suitability for microfluidics...
March 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28280986/caregivers-of-patients-with-amyotrophic-lateral-sclerosis-investigating-quality-of-life-caregiver-burden-service-engagement-and-patient-survival
#14
Tom Burke, Miriam Galvin, Marta Pinto-Grau, Katie Lonergan, Caoifa Madden, Iain Mays, Sile Carney, Orla Hardiman, Niall Pender
Few studies in amyotrophic lateral sclerosis (ALS) have profiled disease-specific features of the condition in conjunction with assessment of caregivers' burden, distress, quality of life, and investigated patient survival. Eighty-four ALS patients and their primary caregivers were enrolled. Patients completed ALS-specific measures of physical and cognitive function, while caregivers completed measures of anxiety, depression, caregiver burden, and quality of life. Patient-caregiver dyads were interviewed about their health-service utilisation...
March 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28275117/randomized-phase-ii-trial-of-parsatuzumab-anti-egfl7-or-placebo-in-combination-with-folfox-and-bevacizumab-for-first-line-metastatic-colorectal-cancer
#15
Rocío García-Carbonero, Eric van Cutsem, Fernando Rivera, Jacek Jassem, Ira Gore, Niall Tebbutt, Fadi Braiteh, Guillem Argiles, Zev A Wainberg, Roel Funke, Maria Anderson, Bruce McCall, Mark Stroh, Eric Wakshull, Priti Hegde, Weilan Ye, Daniel Chen, Ilsung Chang, Ina Rhee, Herbert Hurwitz
LESSONS LEARNED: These negative phase II results for parsatuzumab highlight the challenges of developing an agent intended to enhance the efficacy of vascular endothelial growth factor inhibition without the benefit of validated pharmacodynamic biomarkers or strong predictive biomarker hypotheses.Any further clinical development of anti-EGFL7 is likely to require new mechanistic insights and biomarker development for antiangiogenic agents. BACKGROUND: EGFL7 (epidermal growth factor-like domain 7) is a tumor-enriched vascular extracellular matrix protein that supports endothelial cell survival...
March 8, 2017: Oncologist
https://www.readbyqxmd.com/read/28273065/complex-multi-enhancer-contacts-captured-by-genome-architecture-mapping
#16
Robert A Beagrie, Antonio Scialdone, Markus Schueler, Dorothee C A Kraemer, Mita Chotalia, Sheila Q Xie, Mariano Barbieri, Inês de Santiago, Liron-Mark Lavitas, Miguel R Branco, James Fraser, Josée Dostie, Laurence Game, Niall Dillon, Paul A W Edwards, Mario Nicodemi, Ana Pombo
The organization of the genome in the nucleus and the interactions of genes with their regulatory elements are key features of transcriptional control and their disruption can cause disease. Here we report a genome-wide method, genome architecture mapping (GAM), for measuring chromatin contacts and other features of three-dimensional chromatin topology on the basis of sequencing DNA from a large collection of thin nuclear sections. We apply GAM to mouse embryonic stem cells and identify enrichment for specific interactions between active genes and enhancers across very large genomic distances using a mathematical model termed SLICE (statistical inference of co-segregation)...
March 8, 2017: Nature
https://www.readbyqxmd.com/read/28259482/accuracy-of-postresuscitation-team-debriefings-in-a-pediatric-emergency-department
#17
Paul C Mullan, Niall H Cochrane, James M Chamberlain, Randall S Burd, Fawn D Brown, Lauren E Zinns, Kristen M Crandall, Karen J O'Connell
STUDY OBJECTIVE: Guideline committees recommend postresuscitation debriefings to improve performance. "Hot" postresuscitation debriefings occur immediately after the event and rely on team recall. We assessed the ability of resuscitation teams to recall their performance in team-based, hot debriefings in a pediatric emergency department (ED), using video review as the criterion standard. We hypothesized that debriefing accuracy will improve during the course of the study. METHODS: Resuscitation physician and nurse leaders cofacilitated debriefings after ED resuscitations involving cardiopulmonary resuscitation (CPR) or intubation...
March 1, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28245137/severity-of-hypoxemia-and-effect-of-high-frequency-oscillatory-ventilation-in-ards
#18
Maureen O Meade, Duncan Young, Steven Hanna, Qi Zhou, Thomas E Bachman, Casper Bollen, Arthur S Slutsky, Sarah E Lamb, Neill Kj Adhikari, Spyros D Mentzelopoulos, Deborah J Cook, Sachin Sud, Roy G Brower, B Taylor Thompson, Sanjoy Shah, Alex Stenzler, Gordon Guyatt, Niall D Ferguson
RATIONALE: High frequency oscillatory ventilation (HFOV) is theoretically beneficial for lung protection but the results of clinical trials are inconsistent, with study-level meta-analyses suggesting no significant effect on mortality. OBJECTIVES: The aim of this individual patient data meta-analysis was to identify ARDS patient subgroups with differential outcomes from HFOV. METHODS: After a comprehensive search for trials, two reviewers independently identified randomized trials comparing HFOV with conventional ventilation for adults with ARDS...
February 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28241613/regrowth-free-integration-of-injection-locked-slotted-laser-with-an-electroabsorption-modulator
#19
Niall P Kelly, Ludovic Caro, Mohamad Dernaika, Frank H Peters
Optical injection locking was used to red shift an integrated semiconductor laser up to 30 nm away from the main free running lasing mode. This injection locking of the laser beyond its band edge enabled its integration with an electroabsorption modulator to produce a 2.5 Gb/s eye diagram. The electroabsorption modulator was shown to have a 3 dB bandwidth of 5.5 GHz, which was limited by the contact capacitance. This paper demonstrates that such devices could be applied in a regrowth free, monolithic coherent wavelength division multiplexing transmitter...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28241417/long-term-amperometric-recordings-in-the-brain-extracellular-fluid-of-freely-moving-immunocompromised-nod-scid-mice
#20
Caroline H Reid, Niall J Finnerty
We describe the in vivo characterization of microamperometric sensors for the real-time monitoring of nitric oxide (NO) and oxygen (O₂) in the striatum of immunocompromised NOD SCID mice. The latter strain has been utilized routinely in the establishment of humanized models of disease e.g., Parkinson's disease. NOD SCID mice were implanted with highly sensitive and selective NO and O₂ sensors that have been previously characterized both in vitro and in freely moving rats. Animals were systemically administered compounds that perturbed the amperometric current and confirmed sensor performance...
February 22, 2017: Sensors
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