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JOURNAL ARTICLE
Katie Ridge, Barry Moran, P Abigail Alvarado-Vazquez, Jenny Hallgren, Mark A Little, Alan D Irvine, Cliona O'Farrelly, Jean Dunne, Conor M Finlay, Niall Conlon
BACKGROUND: Chronic spontaneous urticaria (CSU) is a common, debilitating skin disorder characterized by recurring episodes of raised, itchy and sometimes painful wheals lasting longer than 6 weeks. CSU is mediated by mast cells which are absent from peripheral blood. However, lineage- CD34hi CD117int/hi FcεRI+ cells in blood have previously been shown to represent a mast cell precursor. METHODS: We enumerated FcεRI- , FcεRI+ and FcεRIhi lineage- CD34+ CD117+ cells using flow cytometry in blood of patients with CSU (n = 55), including 12 patients receiving omalizumab and 43 not receiving omalizumab (n = 43)...
April 17, 2024: Allergy
#2
JOURNAL ARTICLE
Jacqueline K Faherty, Ben Burningham, Jonathan Gagné, Genaro Suárez, Johanna M Vos, Sherelyn Alejandro Merchan, Caroline V Morley, Melanie Rowland, Brianna Lacy, Rocio Kiman, Dan Caselden, J Davy Kirkpatrick, Aaron Meisner, Adam C Schneider, Marc Jason Kuchner, Daniella Carolina Bardalez Gagliuffi, Charles Beichman, Peter Eisenhardt, Christopher R Gelino, Ehsan Gharib-Nezhad, Eileen Gonzales, Federico Marocco, Austin James Rothermich, Niall Whiteford
Beyond our Solar System, aurorae have been inferred from radio observations of isolated brown dwarfs1,2 . Within our Solar System, giant planets have auroral emission with signatures across the electromagnetic spectrum including infrared emission of H3 + and methane. Isolated brown dwarfs with auroral signatures in the radio have been searched for corresponding infrared features, but only null detections have been reported3 . CWISEP J193518.59-154620.3. (W1935 for short) is an isolated brown dwarf with a temperature of approximately 482 K...
April 2024: Nature
#3
Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Jeffrey O'Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, James F M Meaney, Ignacio Martin-Loeches, Aideen Long, Cliona Ni Cheallaigh, Niall Conlon, Colin P Doherty, Matthew Campbell
No abstract text is available yet for this article.
April 16, 2024: Nature Neuroscience
#4
JOURNAL ARTICLE
Lung-Yu Liang, Niall D Geoghegan, Michael Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin Shepherd, Debnath Ghosal, Kelly L Rogers, James M Murphy, Isabelle S Lucet
EphB6 is an understudied ephrin receptor tyrosine pseudokinase that is downregulated in multiple types of metastatic cancers. Unlike its kinase-active counterparts which autophosphorylate and transmit signals upon intercellular interaction, little is known about how EphB6 functions in the absence of intrinsic kinase activity. Here, we unveil a molecular mechanism of cell-cell interaction driven by EphB6. We identify ephrinB1 as a cognate ligand of EphB6 and show that in trans interaction of EphB6 with ephrinB1 on neighboring cells leads to the formation of large co-clusters at the plasma membrane...
April 16, 2024: Communications Biology
#5
JOURNAL ARTICLE
Amit Rawal, Vuong Truong, Yu-Hui Lo, Lin-Yuan Tseng, Niall W Duncan
Computer code plays a vital role in modern science, from the conception and design of experiments through to final data analyses. Open sharing of code has been widely discussed as being advantageous to the scientific process, allowing experiments to be more easily replicated, helping with error detection, and reducing wasted effort and resources. In the case of psychology, the code used to present stimuli is a fundamental component of many experiments. It is not known, however, the degree to which researchers are sharing this type of code...
April 16, 2024: Behavior Research Methods
#6
JOURNAL ARTICLE
Alison Starke, Jacqueline Poxon, Kishen Patel, Paula Wells, Max Morris, Pandora Rudd, Karen Tipples, Niall MacDougall
OBJECTIVES: To determine if Limbus, an AI auto-contouring software, can offer meaningful time savings for prostate radiotherapy treatment planning. METHODS: Three clinical oncologists recorded the time taken to contour prostate and seminal vesicles, lymph nodes, bladder, rectum, bowel and femoral heads on CT scans for 30 prostate patients (15 prostate, 15 prostate and nodes). Limbus 1.6.0 was used to generate these contours on the 30 CT scans. The time taken by the oncologists to modify individual Limbus contours was noted and compared with manual contouring times...
April 16, 2024: British Journal of Radiology
#7
JOURNAL ARTICLE
Niall Simmons, Miguel Rodriguez Ruiz, Flaminia Ronca
Mixed-gender studies predominate the current literature exploring the interaction between physical activity and dementia risk. Considering that menopause appears to contribute to females' increased risk of cognitive decline when compared to males, further clarity is required on the impact of physical activity in reducing late-life dementia risk specifically in perimenopausal females. A literature search of MEDLINE, EMBASE, Web of Science, SCOPUS and CINAHL databases yielded fourteen studies for review. A significant inverse relationship between perimenopausal leisure time physical activity, or physical fitness, and future all-cause dementia risk was found in most studies exploring this interaction...
April 16, 2024: International Journal of Sports Medicine
#8
JOURNAL ARTICLE
Neil Heron, Xavier Bigard, Niall Elliott, Emma Lunan, Thomas Fallon, Debbie Palmer
The sport of cycling consists of several individual sporting disciplines. Indeed, the world governing body for cycling, Union Cycliste Internationale (UCI), oversees the various cycling disciplines, with each of these disciplines having a number of subcategories. While several sports have undertaken prospective injury surveillance studies to understand the risks of their sport, plan event medical support and develop prevention programmes, limited high-quality studies have been undertaken within cycling. Indeed, this is the first prospective study of cycling injuries, particularly when considering the whole sport of cycling together...
2024: BMJ Open Sport & Exercise Medicine
#9
REVIEW
Anis A Hamid, Christopher J Sweeney, Christopher Hovens, Niall Corcoran, Arun A Azad
Greater personalization of cancer medicine continues to shape therapy development and patient selection accordingly. The treatment of prostate cancer has evolved considerably since the discovery of androgen deprivation therapy. The comprehensive profiling of the prostate cancer genome has mapped the targetable molecular landscape of the disease and identified opportunities for the implementation of novel and combination therapies. In this review, we provide an overview of the molecular biology of prostate cancer and tools developed to aid prognostication and prediction of therapy benefit...
April 12, 2024: Urologic Oncology
#10
REVIEW
Hugo C Temperley, Timothy Fannon, Niall J O'Sullivan, Maeve O'Neill, Benjamin M Mac Curtain, Charles Gilham, Jacintha O'Sullivan, Grainne O'Kane, Brian J Mehigan, Sharon O'Toole, John O Larkin, David Gallagher, Paul McCormick, Michael E Kelly
This systematic review investigates the potential of circulating tumour DNA (ctDNA) as a predictive biomarker in the management and prognosis of squamous cell carcinoma of the anal canal (SCCA). PubMed, EMBASE, and Cochrane Central Registry of Controlled Trials were searched until 7 January 2024. Selection criteria included research articles exploring ctDNA in the context of anal cancer treatment response, recurrence risk assessment, and consideration of salvage surgery. A total of eight studies were therefore included in the final review, examining a total of 628 patients...
April 3, 2024: International Journal of Molecular Sciences
#11
JOURNAL ARTICLE
Edson Sandoval-Castellanos, Andrew J Hare, Audrey T Lin, Evangelos A Dimopoulos, Kevin G Daly, Sheila Geiger, Victoria E Mullin, Ingrid Wiechmann, Valeria Mattiangeli, Gesine Lühken, Natalia A Zinovieva, Petar Zidarov, Canan Çakırlar, Simon Stoddart, David Orton, Jelena Bulatović, Marjan Mashkour, Eberhard W Sauer, Liora Kolska Horwitz, Barbara Horejs, Levent Atici, Vecihi Özkaya, Jacqui Mullville, Michael Parker Pearson, Ingrid Mainland, Nick Card, Lisa Brown, Niall Sharples, David Griffiths, David Allen, Benjamin Arbuckle, Jordan T Abell, Güneş Duru, Susan M Mentzer, Natalie D Munro, Melis Uzdurum, Sevil Gülçur, Hijlke Buitenhuis, Elena Gladyr, Mary C Stiner, Nadja Pöllath, Mihriban Özbaşaran, Stefan Krebs, Joachim Burger, Laurent Frantz, Ivica Medugorac, Daniel G Bradley, Joris Peters
Occupied between ~10,300 and 9300 years ago, the Pre-Pottery Neolithic site of Aşıklı Höyük in Central Anatolia went through early phases of sheep domestication. Analysis of 629 mitochondrial genomes from this and numerous sites in Anatolia, southwest Asia, Europe, and Africa produced a phylogenetic tree with excessive coalescences (nodes) around the Neolithic, a potential signature of a domestication bottleneck. This is consistent with archeological evidence of sheep management at Aşıklı Höyük which transitioned from residential stabling to open pasturing over a millennium of site occupation...
April 12, 2024: Science Advances
#12
JOURNAL ARTICLE
Justin Engelmann, Stephanie Kearney, Alice McTrusty, Greta McKinlay, Miguel O Bernabeu, Niall Strang
PURPOSE: To investigate whether fractal dimension (FD), a retinal trait relating to vascular complexity and a potential "oculomics" biomarker for systemic disease, is applicable to a mixed-age, primary-care population. METHODS: We used cross-sectional data (96 individuals; 183 eyes; ages 18-81 years) from a university-based optometry clinic in Glasgow, Scotland, to study the association between FD and systemic health. We computed FD from color fundus images using Deep Approximation of Retinal Traits (DART), an artificial intelligence-based method designed to be more robust to poor image quality...
April 2, 2024: Translational Vision Science & Technology
#13
REVIEW
Hugo C Temperley, Niall J O'Sullivan, Benjamin M Mac Curtain, Wanyang Qian, Tatiana S Temperley, Alannah Murray, Alison Corr, Ian Brennan, David Gallagher, James F Meaney, Michael E Kelly
PURPOSE: This systematic review evaluated whole-body MRI (WB-MRI) as a cancer screening tool for individuals carrying germline TP53 mutations, a population known to be at a significantly elevated risk of malignancy. The primary objective is to assess the diagnostic performance of WB-MRI in detecting cancer in this cohort. METHODS: PubMed, MEDLINE, EMBASE and the Cochrane Central Registry of Controlled Trials were searched until 18 August 2023. Eligible studies were selected based on predefined inclusion criteria...
February 21, 2024: Journal of Clinical Medicine
#14
JOURNAL ARTICLE
Lisa Asciak, Roger Domingo-Roca, Jamie R Dow, Robbie Brodie, Niall Paterson, Philip E Riches, Wenmiao Shu, Christopher McCormick
Despite polyester vascular grafts being routinely used in life-saving aortic aneurysm surgeries, they are less compliant than the healthy, native human aorta. This mismatch in mechanical behaviour has been associated with disruption of haemodynamics contributing to several long-term cardiovascular complications. Moreover, current fabrication approaches mean that opportunities to personalise grafts to the individual anatomical features are limited. Various modifications to graft design have been investigated to overcome such limitations; yet optimal graft functionality remains to be achieved...
March 30, 2024: Journal of the Mechanical Behavior of Biomedical Materials
#15
JOURNAL ARTICLE
Charles R Treleven, Mary A Kishe, Mathew O Silas, Benjamin P Ngatunga, Bigeyo N Kuboja, Said S Mgeleka, Amy L Taylor, Megan A M Elsmore, Amy J E Healey, Warwick H H Sauer, Paul W Shaw, Niall J McKeown
Octopus cyanea (Gray, 1849), abundant in the South-West Indian Ocean (SWIO), constitutes a vital resource for both subsistence and commercial fisheries. However, despite this socioeconomic importance, and recent indications of overfishing, little is known about the population structure of O. cyanea in the region. To inform sustainable management strategies, this study assessed the spatio-temporal population structure and genetic variability of O. cyanea at 20 sites in the SWIO (Kenya, Tanzania, Mozambique, Madagascar, Mauritius, Rodrigues, and the Seychelle Islands) by complementary analysis of mitochondrial DNA (mtDNA) noncoding region (NCR) sequences and microsatellite markers...
April 2024: Ecology and Evolution
#16
JOURNAL ARTICLE
Adrian Franke, Jan Bernard Matschke, Bernhard Weiland, Tom Alexander Schröder, Niall M H McLeod, Günter Lauer, Henry Leonhardt
Fractures of the mandibular condyle account for a significant proportion of mandibular fractures. The specific functional loads require particular specifications for the implant design used for open reduction and internal fixation of such fractures. The clinical and radiographic outcomes in patients treated using a single rhombic 3D condylar fracture plate for open reduction and internal fixation at a single institution, and who fulfilled the inclusion and exclusion criteria, are presented. The primary outcome variables were: occlusion, maximum interincisal distance and mandibular excursion at 1, 3, and 6 months postoperatively, and radiographic measurements for mandibular height and gonion angle...
March 21, 2024: Journal of Cranio-maxillo-facial Surgery
#17
JOURNAL ARTICLE
Robert A Keenan, Aisling U Nic An Riogh, David Brennan, Martina Morrin, Michael J Lee, Niall F Davis, Atakelet A Ferede, Dilly M Little
PURPOSE: A living donor kidney transplant is the optimal treatment for chronic renal impairment. Our objective is to assess if lean skeletal muscle mass and donor factors such as body mass index, hypertension, and age impact on renal function following donor nephrectomy. METHODS: Potential donors undergo CT angiography as part of their work-up in our institution. Using dedicated software (Horos®), standardized skeletal muscle area measured at the L3 vertebrae was calculated...
April 6, 2024: World Journal of Urology
#18
REVIEW
Daniel Ruivo Marques, Luís Pires, Niall M Broomfield, Colin A Espie
Insomnia disorder is characterized by disruption in sleep continuity and an overall dissatisfaction with sleep. A relevant feature of insomnia is sleep effort, which refers to both cognitive and behavioural conscious attempts to initiate sleep. The Glasgow Sleep Effort Scale is a self-report tool developed to assess this construct. The objective of the current scoping review was to map how sleep effort has been discussed in the literature and operationalized through its respective measure. Medline/PubMed, Scopus, Web of Science and PsycInfo databases were used to search for potential studies...
April 6, 2024: Journal of Sleep Research
#19
JOURNAL ARTICLE
Matthew P Deek, Philip Sutera, Yuezhou Jing, Robert Gao, Emily Rothman, Heather Day, David Chang, Piet Dirix, Andrew J Armstrong, Bethany Campbell, Fernando Lopez Campos, Miguel Berenguer, Matthew Ramotar, Antonio Conde-Moreno, Alejandro Berlin, Davide Giovanni Bosetti, Niall Corcoran, Bridget Koontz, Carole Mercier, Shankar Siva, David Pryor, Piet Ost, Mai Anh Huynh, Stephanie Kroeze, Bradley Stish, Ana Kiess, Bruce Trock, Phuoc T Tran, Silke Gillessen, Christopher Sweeney
BACKGROUND: Metastasis-directed therapy (MDT) is increasingly being used in oligometastatic castration-sensitive prostate cancer (omCSPC). However, it is currently unclear how to optimally integrate MDT with the standard of care of systemic hormonal therapy. OBJECTIVE: To report long-term outcomes of MDT alone versus MDT and a defined course of androgen deprivation therapy (ADT) in omCSPC. DESIGN, SETTING, AND PARTICIPANTS: Here, a multicenter, international retrospective cohort of omCSPC as defined by conventional imaging was reported...
April 2, 2024: European Urology Oncology
#20
JOURNAL ARTICLE
Claire Reimer, Sherlissa Ali-Thompson, Raseel Althawadi, Niall O'Brien, Catherine Nora Moran, Anne Hickey
OBJECTIVES: With the rising global burden of stroke-related morbidity, and increased focus on patient-centered healthcare, patient reported outcome measures (PROMs) are increasingly used to inform healthcare decision-making. Some stroke patients with cognitive or motor impairments are unable to respond to PROMs, so proxies may respond on their behalf; the reliability of which remains unclear. The aim of the study is to update a 2010 systematic review to investigate the inter-rater reliability of proxy respondents answering PROMs for stroke patients...
April 1, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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