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https://www.readbyqxmd.com/read/28916584/novel-insights-into-the-clinical-phenotype-and-pathophysiology-underlying-low-vwf-levels
#1
Michelle Lavin, Sonia Aguila, Sonja Schneppenheim, Niall Dalton, Kenneth L Jones, Jamie M O'Sullivan, Niamh M O'Connell, Kevin Ryan, Barry White, Mary Byrne, Marie Rafferty, Mairead M Doyle, Margaret Nolan, Roger J S Preston, Ulrich Budde, Paula James, Jorge Di Paola, James S O'Donnell
Critical clinical questions remain unanswered regarding diagnosis and management of patients with Low VWF levels (30-50 IU/dL). To address these questions, the Low VWF Ireland Cohort (LoVIC) study investigated 126 patients registered with Low VWF. Interestingly, despite their marginally reduced plasma VWF levels, ISTH BAT and Condensed MCMDM-1 VWD scores both confirmed significant bleeding phenotypes in the majority of LoVIC patients. For example, among female patients with Low VWF, 77% had ISTH BAT scores ≥6...
September 15, 2017: Blood
https://www.readbyqxmd.com/read/28910146/management-of-ards-and-refractory-hypoxemia-a-multicenter-observational-study
#2
Erick H Duan, Neill Kj Adhikari, Frederick D'Aragon, Deborah J Cook, Sangeeta Mehta, Waleed Alhazzani, Ewan Goligher, Emmanuel Charbonney, Yaseen M Arabi, Tim Karachi, Alexis F Turgeon, Lori Hand, Qi Zhou, Peggy Austin, Jan Friedrich, Francois Lamontagne, François Lauzier, Rakesh Patel, John Muscedere, Richard Hall, Pierre Aslanian, Thomas Piraino, Martin Albert, Sean M Bagshaw, Mike Jacka, Gordon Wood, William Henderson, Delbert Dorscheid, Niall D Ferguson, Maureen O Meade
RATIONALE: Clinicians' current practice patterns in the management of acute respiratory distress syndrome (ARDS) and refractory hypoxemia are not well described. OBJECTIVES: To describe mechanical ventilation strategies and treatment adjuncts for adults with ARDS including refractory hypoxemia. METHODS: Prospective cohort study (March 2014-February 2015) of mechanically ventilated adults with moderate-to-severe ARDS requiring FiO2 ≥0.50 in 24 ICUs...
September 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28905623/electropumping-of-water-through-human-aquaporin-4-by-circularly-polarized-electric-fields-dramatic-enhancement-and-control-revealed-by-non-equilibrium-molecular-dynamics
#3
Christian J Burnham, Niall J English
An extensive suite of nonequilibrium molecular-dynamics (NEMD) simulations have been performed for ∼60 ns of human aquaporin 4 in externally applied circularly polarized (CP) electric fields, applied axially along channels. These external fields were 0.05 V/Å in intensity and 100 GHz in frequency. This has the effect of "electro-pumping" the water through the pores as prototypical biochannels, from conversion of molecules' spin angular momentum to linear momentum in the asymmetric heterogeneous-frictional environment of the pores, thus inducing overall net flow...
September 14, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28903709/the-influence-of-daily-coping-on-anxiety-under-examination-stress-a-model-of-interindividual-differences-in-intraindividual-change
#4
Masumi Iida, Marci Gleason, Amie S Green-Rapaport, Niall Bolger, Patrick E Shrout
Although much is known about people's attempts to cope with stressors, unmeasured heterogeneity in these stressors has made it difficult to assess the effectiveness of coping attempts. We remedied this problem by focusing on coping effectiveness in people preparing for a major, planned, uniform stressor, the Bar Examination. Within-person analyses of longitudinal data on anxiety in 321 persons over 35 days provided evidence on (a) coping effectiveness for the typical person, (b) how effectiveness changed across time, and (c) the extent to which individuals differed in their effectiveness...
July 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28892508/physical-psychological-sexual-and-systemic-abuse-of-children-with-disabilities-in-east-africa-mapping-the-evidence
#5
Niall Winters, Laurenz Langer, Anne Geniets
Children with disabilities (CWDs) are at a higher risk of being maltreated than are typical children. The evidence base on the abuse of children with disabilities living in low- and middle-income countries is extremely limited but the problem is particularly acute in East Africa. We don't know the types of evidence that exist on this topic. This problem is compounded by the fact that key indicators of disability, such as reliable prevalence rates, are not available currently. This paper addresses this serious problem by mapping the existing evidence-base to document the coverage, patterns, and gaps in existing research on the abuse of children with disabilities in East Africa...
2017: PloS One
https://www.readbyqxmd.com/read/28887146/analysing-the-effect-of-multiple-sclerosis-on-vitamin-d-related-biochemical-markers-of-bone-remodelling
#6
Malachi J McKenna, Barbara Murray, Roisin Lonergan, Ricardo Segurado, Niall Tubridy, Mark T Kilbane
The Irish population is at risk of vitamin D deficiency during the winter months, but the secular trend over the past 40 years is for marked improvement. Multiple sclerosis (MS) is common in Ireland with a latitudinal pattern favouring highest incidence in northern regions; MS is linked strongly with vitamin D status as a causal factor. We sought firstly to study the relationship between vitamin D status and vitamin D-related bone biochemistry, and secondly to evaluate if MS had an independent effect on vitamin D related markers of bone remodelling...
September 5, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28884710/atmospheric-pulsed-laser-deposition-and-thermal-annealing-of-plasmonic-silver-nanoparticle-films
#7
Taj M Khan, Mubarak M Mujawar, Katarzyna E Siewerska, Anuj Pokle, Tony Donnelly, Niall McEvoy, Georg S Duesberg, James G Lunney
A new method for pulsed laser deposition of plasmonic silver nanoparticle films in flowing gas at atmospheric pressure is described. The ablation was done using an excimer laser at 248 nm. Fast optical imaging shows that the ablation plume is captured by the flowing gas, and is expected to form a nanoparticle aerosol, which is carried 5 - 20 mm to the substrate. The dependence of the deposition rate on laser fluence, gas flow velocity, and target-substrate distance was investigated using electron microscopy and absorption spectroscopy of the deposited films...
September 8, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28881726/modulation-of-paracrine-signaling-by-cd9-positive-small-extracellular-vesicles-mediates-cellular-growth-of-androgen-deprived-prostate-cancer
#8
Carolina Soekmadji, James D Riches, Pamela J Russell, Jayde E Ruelcke, Stephen McPherson, Chenwei Wang, Chris M Hovens, Niall M Corcoran, Michelle M Hill, Colleen C Nelson
Proliferation and maintenance of both normal and prostate cancer (PCa) cells is highly regulated by steroid hormones, particularly androgens, and the extracellular environment. Herein, we identify the secretion of CD9 positive extracellular vesicles (EV) by LNCaP and DUCaP PCa cells in response to dihydrotestosterone (DHT) and use nano-LC-MS/MS to identify the proteins present in these EV. Subsequent bioinformatic and pathway analyses of the mass spectrometry data identified pathologically relevant pathways that may be altered by EV contents...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881357/a-novel-inhibitory-anti-invasive-mab-isolated-using-phenotypic-screening-highlights-anxa6-as-a-functionally-relevant-target-protein-in-pancreatic-cancer
#9
Dermot O'Sullivan, Paul Dowling, Helena Joyce, Edel McAuley, Andrew McCann, Michael Henry, Brianan McGovern, Paul Barham, Fergal C Kelleher, Jean Murphy, Susan Kennedy, Niall Swan, Michael Moriarty, Martin Clynes, Annemarie Larkin
BACKGROUND: Discovery and validation of new antibody tractable targets is critical for the development of new antibody therapeutics to address unmet needs in oncology. METHODS: A highly invasive clonal variant of the MDA-MB-435S cell line was used to generate monoclonal antibodies (MAbs), which were screened for anti-invasive activity against aggressive cancer cells in vitro. The molecular target of selected inhibitory MAb 9E1 was identified using immunoprecipitation/liquid chromatography-tandem mass spectrometry...
September 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28878595/neoadjuvant-platinum-based-chemotherapy-is-an-independent-predictor-for-preoperative-thromboembolic-events-in-bladder-cancer-patients-undergoing-radical-cystectomy
#10
Cliodhna Browne, Niall F Davis, William J Nolan, Eoin D MacCraith, Gerald M Lennon, David W Mulvin, David J Galvin, David M Quinlan
INTRODUCTION: Neoadjuvant chemotherapy (NAC) confers a significant survival benefit in patients with muscle invasive bladder cancer. Platinum-based chemotherapy increases the risk of thromboembolic events (TEE). We determined the effect of cisplatin-based NAC on the incidence of preoperative TEEs in radical cystectomy patients. MATERIALS AND METHODS: A retrospective matched case-control study was performed on 55 patients undergoing radical cystectomy for muscle invasive bladder cancer...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28870862/incidence-clinicopathologic-risk-factors-management-and-outcomes-of-non-muscle-invasive-recurrences-after-complete-response-to-tri-modality-therapy-for-muscle-invasive-bladder-cancer
#11
Alejandro Sanchez, Matthew F Wszolek, Andrzej Niemierko, Rebecca H Clayman, Michael Drumm, Dayron Rodríguez, Adam S Feldman, Douglas M Dahl, Niall M Heney, William U Shipley, Anthony L Zietman, Jason A Efstathiou
PURPOSE: To describe the incidence, clinicopathologic risk factors, management, and outcomes of non-muscle invasive bladder cancer (NMIBC) recurrences after complete response (CR) to tri-modality therapy (TMT) for muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS: Patients with cT2-4aN0M0 MIBC (n=342) and CR after TMT were reviewed retrospectively (1986-2013). Using competing risks analyses, the association between baseline clinicopathologic variables and NMIBC outcomes was examined...
September 1, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28864449/feasibility-and-acceptability-of-a-patient-reported-outcome-intervention-in-chronic-heart-failure
#12
Pauline M Kane, Barbara A Daveson, Karen Ryan, Clare I Ellis-Smith, Niall G Mahon, Brendan McAdam, Regina McQuilllan, Cecelia Tracey, Christine Howley, Geraldine O'Gara, Caroline Raleigh, Irene J Higginson, Jonathan Koffman, Fliss E M Murtagh
Patients with chronic heart failure (CHF) have symptoms and concerns which are inadequately addressed. Patient-reported outcome measures (PROMs) can potentially improve the identification and management of advanced symptoms and palliative concerns. However, these have not been used in CHF. OBJECTIVES: To examine the feasibility and acceptability of using a PROM-the Integrated Palliative care Outcome Scale (IPOS)-together with heart failure nurse education and training to improve the identification and management of symptoms and concerns among patients with CHF...
September 1, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28861032/mismatch-negativity-as-an-indicator-of-cognitive-sub-domain-dysfunction-in-amyotrophic-lateral-sclerosis
#13
Parameswaran Mahadeva Iyer, Kieran Mohr, Michael Broderick, Brighid Gavin, Tom Burke, Peter Bede, Marta Pinto-Grau, Niall P Pender, Russell McLaughlin, Alice Vajda, Mark Heverin, Edmund C Lalor, Orla Hardiman, Bahman Nasseroleslami
OBJECTIVE: To evaluate the utility of mismatch negativity (MMN), a neurophysiologic marker of non-motor cognitive processing, in amyotrophic lateral sclerosis (ALS). METHODS: 89 patients, stratified into 4 different phenotypic presentations of ALS (67 spinal-onset, 15 bulbar-onset, 7 ALS-FTD, 7 C9ORF72 gene careers), and 19 matched controls underwent 128-channel EEG data recording. Subjects were presented with standard auditory tones interleaved with pitch-deviant tones in three recording blocks...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28859061/is-the-new-zealand-early-warning-score-useful-following-cardiac-surgery
#14
Kevin Niall Peek, Michael Gillham
AIMS: The rate of medical emergency team (MET) calling among post-cardiac surgery patients is unknown. We set out to determine what the call frequency would be if MET activation occurred in every instance that the early warning score (EWS) breached our local threshold, what the outcome was for these patients and what the calling rate might be if the proposed New Zealand EWS (NZEWS) system was implemented with 100% adherence. METHODS: The clinical records of 400 consecutive post-cardiac surgery patients were examined...
September 1, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28858267/novel-selective-estrogen-receptor-ligand-conjugates-incorporating-endoxifen-combretastatin-and-cyclofenil-combretastatin-hybrid-scaffolds-synthesis-and-biochemical-evaluation
#15
Patrick M Kelly, Niall O Keely, Sandra A Bright, Bassem Yassin, Gloria Ana, Darren Fayne, Daniela M Zisterer, Mary J Meegan
Nuclear receptors such as the estrogen receptors (ERα and ERβ) modulate the effects of the estrogen hormones and are important targets for design of innovative chemotherapeutic agents for diseases such as breast cancer and osteoporosis. Conjugate and bifunctional compounds which incorporate an ER ligand offer a useful method of delivering cytotoxic drugs to tissue sites such as breast cancers which express ERs. A series of novel conjugate molecules incorporating both the ER ligands endoxifen and cyclofenil-endoxifen hybrids covalently linked to the antimitotic and tubulin targeting agent combretastatin A-4 were synthesised and evaluated as ER ligands...
August 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28856701/extracellular-vesicles-for-personalized-therapy-decision-support-in-advanced-metastatic-cancers-and-its-potential-impact-for-prostate-cancer
#16
REVIEW
Carolina Soekmadji, Niall M Corcoran, Irina Oleinikova, Lidija Jovanovic, Grant A Ramm, Colleen C Nelson, Guido Jenster, Pamela J Russell
The use of circulating tumor cells (CTCs) and circulating extracellular vesicles (EVs), such as exosomes, as liquid biopsy-derived biomarkers for cancers have been investigated. CTC enumeration using the CellSearch based platform provides an accurate insight on overall survival where higher CTC counts indicate poor prognosis for patients with advanced metastatic cancer. EVs provide information based on their lipid, protein, and nucleic acid content and can be isolated from biofluids and analyzed from a relatively small volume, providing a routine and non-invasive modality to monitor disease progression...
August 29, 2017: Prostate
https://www.readbyqxmd.com/read/28841602/breast-cancer-genetics-for-plastic-surgeons
#17
Niall M McInerney, Steven Narod, Kelly Metcalfe, John Semple, Mitchell H Brown
Multidisciplinary genetic clinics offer counseling and testing to those who meet criteria for familial breast cancer, and plastic surgeons become integral to this process when risk-reducing surgery and postmastectomy reconstruction are deemed appropriate. As reconstructive surgeons, it is important that plastic surgeons are aware of the risks and issues associated with the genetic variants that cause patients to present for prophylactic or therapeutic surgery.
September 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28831317/synchronous-upper-squamous-and-lower-adenocarcinoma-of-the-oesophagus-a-rarely-reported-case-treated-with-palliative-chemotherapy-and-stenting
#18
Niall Hardy, Justin Kelly, John Conneely, Barry Kelleher
Oesophageal cancer is divided into two main subtypes, squamous and adenocarcinoma. It is the eighth most common cancer in the world with squamous more common in the developing world and adenocarcinoma most prevalent in the developed world. Incidences of concomitant squamous carcinoma with adenocarcinoma are exceedingly rare with only a few documented occurrences in the form of case reports existing. Here we report a case of synchronous squamous and adenocarcinoma of the oesophagus occurring in an 81-year-old lady with dysphagia, weight loss, and no identifiable risk factors...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28821866/detection-of-magnetized-quark-nuggets-a-candidate-for-dark-matter
#19
J Pace VanDevender, Aaron P VanDevender, T Sloan, Criss Swaim, Peter Wilson, Robert G Schmitt, Rinat Zakirov, Josh Blum, James L Cross, Niall McGinley
Quark nuggets are theoretical objects composed of approximately equal numbers of up, down, and strange quarks and are also called strangelets and nuclearites. They have been proposed as a candidate for dark matter, which constitutes ~85% of the universe's mass and which has been a mystery for decades. Previous efforts to detect quark nuggets assumed that the nuclear-density core interacts directly with the surrounding matter so the stopping power is minimal. Tatsumi found that quark nuggets could well exist as a ferromagnetic liquid with a ~10(12)-T magnetic field...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813479/metabolomic-profiling-of-amines-in-sepsis-predicts-changes-in-nos-canonical-pathways
#20
Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell
RATIONALE: Nitric oxide synthase (NOS) is a biomarker/target in sepsis. NOS activity is driven by amino acids, which cycle to regulate the substrate L-arginine in parallel with cycles which regulate the endogenous inhibitors ADMA and L-NMMA. The relationship between amines and the consequence of plasma changes on iNOS activity in early sepsis is not known. OBJECTIVE: Our objective was to apply a metabolomics approach to determine the influence of sepsis on a full array of amines and what consequence these changes may have on predicted iNOS activity...
2017: PloS One
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