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https://www.readbyqxmd.com/read/29350759/extreme-rainfall-affects-assembly-of-the-root-associated-fungal-community
#1
Christopher J Barnes, Christopher J van der Gast, Niall P McNamara, Rebecca Rowe, Gary D Bending
Global warming is resulting in increased frequency of weather extremes. Root-associated fungi play important roles in terrestrial biogeochemical cycling processes, but the way in which they are affected by extreme weather is unclear. Here, we performed long-term field monitoring of the root-associated fungus community of a short rotation coppice willow plantation, and compared community dynamics before and after a once in 100 yr rainfall event that occurred in the UK in 2012. Monitoring of the root-associated fungi was performed over a 3-yr period by metabarcoding the fungal internal transcribed spacer (ITS) region...
January 19, 2018: New Phytologist
https://www.readbyqxmd.com/read/29349687/adjunct-and-rescue-therapies-for-refractory-hypoxemia-prone-position-inhaled-nitric-oxide-high-frequency-oscillation-extra-corporeal-life-support
#2
Niall D Ferguson, Claude Guérin
No abstract text is available yet for this article.
January 18, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29344960/association-of-genetic-variation-in-telomere-related-snp-and-telomerase-with-ventricular-arrhythmias-in-ischaemic-cardiomyopathy
#3
Vinit Sawhney, Scott Brouilette, Niall Campbell, Steven Coppen, Victoria Baker, Ross Hunter, Mehul Dhinoja, Atholl Johnston, Mark Earley, Simon Sporton, Ken Suzuki, Richard Schilling
BACKGROUND: Telomeres are known to provide genomic stability and telomere length has been associated with cardiovascular diseases. Moreover, a higher telomerase activity has been shown to be associated with ventricular arrhythmias (VA) in ischaemic cardiomyopathy. Increasing evidence suggests that genetic variation in key telomere genes has an impact on telomerase activity. Each copy of the minor allele of SNP rs12696304, at a locus including TERC (telomerase) has been associated with ∼ 75 bp reduction in mean telomere length likely mediated by an effect on TERC expression...
January 17, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29343728/oxidation-of-sqstm1-p62-mediates-the-link-between-redox-state-and-protein-homeostasis
#4
Bernadette Carroll, Elsje G Otten, Diego Manni, Rhoda Stefanatos, Fiona M Menzies, Graham R Smith, Diana Jurk, Niall Kenneth, Simon Wilkinson, Joao F Passos, Johannes Attems, Elizabeth A Veal, Elisa Teyssou, Danielle Seilhean, Stéphanie Millecamps, Eeva-Liisa Eskelinen, Agnieszka K Bronowska, David C Rubinsztein, Alberto Sanz, Viktor I Korolchuk
Cellular homoeostatic pathways such as macroautophagy (hereinafter autophagy) are regulated by basic mechanisms that are conserved throughout the eukaryotic kingdom. However, it remains poorly understood how these mechanisms further evolved in higher organisms. Here we describe a modification in the autophagy pathway in vertebrates, which promotes its activity in response to oxidative stress. We have identified two oxidation-sensitive cysteine residues in a prototypic autophagy receptor SQSTM1/p62, which allow activation of pro-survival autophagy in stress conditions...
January 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29337534/highly-luminescent-encapsulated-narrow-bandgap-polymers-based-on-diketopyrrolopyrrole
#5
Anastasia Leventis, Jeroen Royakkers, Alexandros G Rapidis, Niall Goodeal, Merina K Corpinot, Jarvist M Frost, Dejan-Krešimir Bučar, Matthew Oliver Blunt, Franco Cacialli, Hugo Bronstein
We present the synthesis and characterisation of a series of encap-sulated diketopyrrolopyrrole red-emitting conjugated polymers. The novel materials display extremely high fluorescence quantum yields in both solution (>70%) and thin film (>20%). Both the absorption and emission spectra show clearer, more defined features compared to their naked counterparts demonstrating the suppression of inter and intra-molecular aggregation. We find that the encapsulation results in decreased energetic disorder and a dramatic increase in backbone co-linearity as evidenced by STM...
January 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29331855/retrievable-inferior-vena-cava-filters-in-pregnancy-risk-versus-benefit
#6
REVIEW
David A Crosby, Kevin Ryan, Niall McEniff, Patrick Dicker, Carmen Regan, Caoimhe Lynch, Bridgette Byrne
OBJECTIVE: Venous thromboembolism remains one of the leading causes of maternal mortality in the developed world. Retrievable inferior vena cava (IVC) filters have a role in the prevention of lethal pulmonary emboli when anticoagulation is contraindicated or has failed [1]. It is unclear whether or not the physiological changes in pregnancy influence efficacy and complications of these devices. The decision to place an IVC filter in pregnancy is complex and there is limited information in terms of benefit and risk to the mother...
December 21, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29328100/high-q-all-dielectric-thermal-emitters-for-mid-infrared-gas-sensing-applications
#7
Muhammad O Ali, Niall Tait, Shulabh Gupta
A simple all-dielectric thermal emitter unit cell for narrowband gas-sensing application is proposed, providing large Q-factors compared to its plasmonic counterpart. It consists of a high-index dielectric-based elliptical puck on top of a back-reflector, providing narrowband thermal emission. Using full-wave simulations, it is demonstrated that the achievable Q-factors in this structure are orders of magnitude larger than what have been shown for plasmonic cells, thanks to their low-loss electrical characteristics...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29326188/managing-cognitive-impairment-following-stroke-protocol-for-a-systematic-review-of-non-randomised-controlled-studies-of-psychological-interventions
#8
Niamh A Merriman, Eithne Sexton, Nora-Ann Donnelly, Grainne McCabe, Mary E Walsh, Daniela Rohde, Ashleigh Gorman, Isabelle Jeffares, Niall Pender, David Williams, Frances Horgan, Frank Doyle, Maev-Ann Wren, Kathleen E Bennett, Anne Hickey
INTRODUCTION: Stroke is one of the primary causes of death and disability worldwide, leaving a considerable proportion of survivors with persistent cognitive and functional deficits. Despite the prevalence of poststroke cognitive impairment, there is no established treatment aimed at improving cognitive function following a stroke. Therefore, the aims of this systematic review are to identify psychological interventions intended to improve poststroke cognitive function and establish their efficacy...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29316106/robotic-assisted-radical-cystectomy-with-intracorporeal-urinary-diversion-versus-open-early-australian-experience
#9
Ken Chow, Homayoun Zargar, Niall M Corcoran, Anthony J Costello, Justin S Peters, Philip Dundee
BACKGROUND: The aim of this study was to describe our initial Australian single surgeon experience with robotic-assisted radical cystectomy (RARC) and intracorporeal urinary diversion (ICUD) and to compare the outcomes with open radical cystectomy (ORC). METHODS: Between January 2014 and June 2016, consecutive patients diagnosed with muscle invasive and high-risk non-muscle invasive bladder cancer undergoing radical cystectomy were included. Treatment modalities included either RARC with ICUD or ORC...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29309542/spatial-patterns-of-progressive-brain-volume-loss-after-moderate-severe-traumatic-brain-injury
#10
James H Cole, Amy Jolly, Sara de Simoni, Niall Bourke, Maneesh C Patel, Gregory Scott, David J Sharp
Traumatic brain injury leads to significant loss of brain volume, which continues into the chronic stage. This can be sensitively measured using volumetric analysis of MRI. Here we: (i) investigated longitudinal patterns of brain atrophy; (ii) tested whether atrophy is greatest in sulcal cortical regions; and (iii) showed how atrophy could be used to power intervention trials aimed at slowing neurodegeneration. In 61 patients with moderate-severe traumatic brain injury (mean age = 41.55 years ± 12.77) and 32 healthy controls (mean age = 34...
January 4, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29307752/a-2-year-comparative-study-of-mold-and-bacterial-counts-in-air-samples-from-neutral-and-positive-pressure-rooms-in-2-tertiary-care-hospitals
#11
Laura Ryan, Niall O'Mara, Sana Tansey, Tom Slattery, Belinda Hanahoe, Akke Vellinga, Maeve Doyle, Martin Cormican
Immunocompromised patients are at risk of invasive fungal infection. These high-risk patients are nursed in protective isolation to reduce the risk of nosocomial aspergillosis while in hospital-ideally in a positive pressure single room with high-efficiency particulate air filtration. However, neutral pressure rooms are a potential alternative, especially for patients requiring both protective and source isolation. This study examined mold and bacterial concentrations in air samples from positive and neutral pressure rooms to assess whether neutral pressure rooms offer a similar environment to that of positive pressure rooms in terms of mold concentrations in the air...
January 4, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29303715/2017-wakley-prize-essay
#12
COMMENT
Joanna Palmer, Niall Boyce, Phoebe Hall, Rhiannon Howe
No abstract text is available yet for this article.
December 23, 2018: Lancet
https://www.readbyqxmd.com/read/29282098/the-impact-of-maintaining-serum-potassium-%C3%A2-3-6-meq-l-vs-%C3%A2-4-5-meq-l-on-the-incidence-of-new-onset-atrial-fibrillation-in-the-first-120-hours-after-isolated-elective-coronary-artery-bypass-grafting-study-protocol-for-a-randomised-feasibility-trial-for-the-proposed
#13
Niall G Campbell, Elizabeth Allen, Julie Sanders, Rebecca Swinson, Sophie Birch, Joanna Sturgess, Nawaf Al-Subaie, Diana Elbourne, Hugh Montgomery, Ben O'Brien
BACKGROUND: Atrial fibrillation (AF) occurs in approximately one in three patients after cardiac surgery, and is associated with increased short-term and long-term mortality, intensive care unit (ICU) and hospital stay, and increased cost of care. In an attempt to reduce AF incidence in these patients, serum potassium (K+) levels are commonly maintained at the high end of normal (4.5-5.5 mEq/L). However, such potassium supplementation is without proven benefit, and is not without negative consequences...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29248689/pattern-of-access-determines-influence-of-junk-food-diet-on-cue-sensitivity-and-palatability
#14
Alisa R Kosheleff, Jingwen Araki, Jennifer Hsueh, Andrew Le, Kevin Quizon, Sean B Ostlund, Nigel T Maidment, Niall P Murphy
AIMS: Like drug addiction, cues associated with palatable foods can trigger food-seeking, even when sated. However, whether susceptibility to the motivating influence of food-related cues is a predisposing factor in overeating or a consequence of poor diet is difficult to determine in humans. Using a rodent model, we explored whether a highly palatable 'junk food' diet impacts responses to reward-paired cues in a Pavlovian-to-instrumental transfer test, using sweetened condensed milk (SCM) as the reward...
December 14, 2017: Appetite
https://www.readbyqxmd.com/read/29248282/extracorporeal-life-support-as-a-bridge-to-lung-transplantation-experience-of-a-high-volume-transplant-center
#15
Konrad Hoetzenecker, Laura Donahoe, Jonathan C Yeung, Sassan Azad, Eddy Fan, Niall D Ferguson, Lorenzo Del Sorbo, Marc de Perrot, Andrew Pierre, Kazuhiro Yasufuku, Lianne Singer, Thomas K Waddell, Shaf Keshavjee, Marcelo Cypel
OBJECTIVES: Extracorporeal life support (ECLS) is increasingly used to bridge deteriorating patients awaiting lung transplantation (LTx), however, few systematic descriptions of this practice exist. We therefore aimed to review our institutional experience over the past 10 years. METHODS: In this case series, we included all adults who received ECLS with the intent to bridge to LTx. Data were retrieved from patient charts and our institutional ECLS and transplant databases...
November 22, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29247385/within-subject-mediation-analysis-for-experimental-data-in-cognitive-psychology-and-neuroscience
#16
Matti Vuorre, Niall Bolger
Statistical mediation allows researchers to investigate potential causal effects of experimental manipulations through intervening variables. It is a powerful tool for assessing the presence and strength of postulated causal mechanisms. Although mediation is used in certain areas of psychology, it is rarely applied in cognitive psychology and neuroscience. One reason for the scarcity of applications is that these areas of psychology commonly employ within-subjects designs, and mediation models for within-subjects data are considerably more complicated than for between-subjects data...
December 15, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/29237794/recommendations-of-the-global-multiple-system-atrophy-research-roadmap-meeting
#17
REVIEW
Ryan R Walsh, Florian Krismer, Wendy R Galpern, Gregor K Wenning, Phillip A Low, Glenda Halliday, Walter J Koroshetz, Janice Holton, Niall P Quinn, Olivier Rascol, Leslie M Shaw, David Eidelberg, Pam Bower, Jeffrey L Cummings, Victor Abler, Judy Biedenharn, Gal Bitan, David J Brooks, Patrik Brundin, Hubert Fernandez, Philip Fortier, Roy Freeman, Thomas Gasser, Art Hewitt, Günter U Höglinger, Matt J Huentelman, Poul H Jensen, Andreas Jeromin, Un Jung Kang, Horacio Kaufmann, Lawrence Kellerman, Vikram Khurana, Thomas Klockgether, Woojin Scott Kim, Carol Langer, Peter LeWitt, Eliezer Masliah, Wassilios Meissner, Ronald Melki, Susanne Ostrowitzki, Steven Piantadosi, Werner Poewe, David Robertson, Cyndi Roemer, Dale Schenk, Michael Schlossmacher, Jeremy D Schmahmann, Klaus Seppi, Lily Shih, Andrew Siderowf, Glenn T Stebbins, Nadia Stefanova, Shoji Tsuji, Sharon Sutton, Jing Zhang
Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy...
January 9, 2018: Neurology
https://www.readbyqxmd.com/read/29233680/new-fpg-probe-chemistry-for-direct-detection-of-recombinase-polymerase-amplification-on-lateral-flow-strips
#18
Michael L Powell, Frank R Bowler, Aurore J Martinez, Catherine J Greenwood, Niall Armes, Olaf Piepenburg
Rapid, cost-effective and sensitive detection of nucleic acids has the ability to improve upon current practices employed for pathogen detection in diagnosis of infectious disease and food testing. Furthermore, if assay complexity can be reduced, nucleic acid amplification tests could be deployed in resource-limited and home use scenarios. In this study, we developed a novel Fpg (Formamidopyrimidine DNA glycosylase) probe chemistry, which allows lateral flow detection of amplification in undiluted recombinase polymerase amplification (RPA) reactions...
December 9, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29220685/parental-psychopathology-adult-attachment-and-risk-of-12-month-suicidal-behaviours
#19
David Boyda, Danielle Mc Feeters, Katie Dhingra, Niall Galbraith, Danny Hinton
BACKGROUND: The mechanisms by which parental psychopathology and vulnerability to suicide is transmitted to offspring is not well understood. parental psychopathology and behaviour may impact upon the normal emotional and psychological adjustment of their offspring in various ways. Research shows attachment insecurities may also be a key factor in the facilitation of suicidal behaviours. OBJECTIVE: To examine adult attachment insecurities as a potential mediating pathway between parental psychopathology and 12-month suicidality...
December 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29220398/a-minimally-invasive-optical-trapping-system-to-understand-cellular-interactions-at-onset-of-an-immune-response
#20
David G Glass, Niall McAlinden, Owain R Millington, Amanda J Wright
T-cells and antigen presenting cells are an essential part of the adaptive immune response system and how they interact is crucial in how the body effectively fights infection or responds to vaccines. Much of the experimental work studying interaction forces between cells has looked at the average properties of bulk samples of cells or applied microscopy to image the dynamic contact between these cells. In this paper we present a novel optical trapping technique for interrogating the force of this interaction and measuring relative interaction forces at the single-cell level...
2017: PloS One
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