keyword
MENU ▼
Read by QxMD icon Read
search

Niall

keyword
https://www.readbyqxmd.com/read/28426931/lead-optimization-of-benzoxepin-type-selective-estrogen-receptor-er-modulators-and-downregulators-with-subtype-specific-er%C3%AE-and-er%C3%AE-activity
#1
Niamh Mary O'Boyle, Irene Barrett, Lisa M Greene, Miriam Carr, Darren Fayne, Brendan Twamley, Andrew J S Knox, Niall O Keely, Daniela M Zisterer, Mary Jane Meegan
Estrogen receptor (ER) is an important target for the design of drugs such as tamoxifen (2a) and fulvestrant (5). Three series of ER-ligands based on the benzoxepin scaffold structure were synthesised - series I containing an acrylic acid, series II with an acrylamide and series III with an acid substuent. These compounds were shown to be high affinity ligands for the ER with nanomolar IC50 binding values. Series I acrylic acid ligands were generally ERα selective. In particular, compound 13e featuring a phenylpenta-2,4-dienoic acid substituent was shown to be antiproliferative and downregulated ERα and ERβ expression in MCF-7 breast cancer cells...
April 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28421528/postnatal-lps-challenge-impacts-escape-learning-and-expression-of-plasticity-factors-mmp9-and-timp1-in-rats-effects-of-repeated-training
#2
Alexander Trofimov, Tatyana Strekalova, Niall Mortimer, Olga Zubareva, Alexander Schwarz, Evgeniy Svirin, Aleksei Umriukhin, Andrei Svistunov, Klaus-Peter Lesch, Victor Klimenko
Bacterial intoxication associated with inflammatory conditions during development can impair brain functions, in particular evolutionarily novel forms of memory, such as explicit learning. Little is known about the dangers of early-life inflammation on more basic forms of learning, for example, the acquisition of motor escape abilities, which are generally better preserved under pathological conditions. To address this limitation in knowledge, an inflammatory response was elicited in Wistar pups by lipopolysaccharide (LPS) injections (25 μg/kg) on postnatal days P15, P18 and P21...
April 18, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28414610/clinical-calculator-for-early-mortality-in-metastatic-colorectal-cancer-an-analysis-of-patients-from-28-clinical-trials-in-the-aide-et-recherche-en-canc%C3%A3-rologie-digestive-database
#3
Lindsay A Renfro, Richard M Goldberg, Axel Grothey, Alberto Sobrero, Richard Adams, Matthew T Seymour, Volker Heinemann, Hans-Joachim Schmoll, Jean-Yves Douillard, Herbert Hurwitz, Charles S Fuchs, Eduardo Diaz-Rubio, Rainer Porschen, Christophe Tournigand, Benoist Chibaudel, Paulo M Hoff, Fairooz F Kabbinavar, Alfredo Falcone, Niall C Tebbutt, Cornelis J A Punt, J Randolph Hecht, John Souglakos, Carsten Bokemeyer, Eric Van Cutsem, Leonard Saltz, Aimery de Gramont, Daniel J Sargent
Purpose Factors contributing to early mortality after initiation of treatment of metastatic colorectal cancer are poorly understood. Materials and Methods Data from 22,654 patients enrolled in 28 randomized phase III trials contained in the ARCAD (Aide et Recherche en Cancérologie Digestive) database were pooled. Multivariable logistic regression models for 30-, 60-, and 90-day mortality were constructed, including clinically and statistically significant patient and disease factors and interaction terms. A calculator (nomogram) for 90-day mortality was developed and validated internally using bootstrapping methods and externally using a 10% random holdout sample from each trial...
April 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28409006/analysis-of-weekend-effect-on-30-day-mortality-among-patients-with-acute-myocardial-infarction
#4
Rebecca Noad, Michael Stevenson, Niall A Herity
OBJECTIVES: Several publications have demonstrated increased 30-day mortality in patients admitted on Saturdays or Sundays compared with weekdays. We sought to determine whether this was true for two different cohorts of patients admitted with acute myocardial infarction (MI). METHODS AND RESULTS: Thirty-day mortality data were obtained for 3757 patients who had been admitted to the Belfast Health and Social Care Trust with acute MI between 2009 and 2015. They were subdivided into those presenting with ST elevation MI (n=2240) and non-ST elevation MI (n= 1517)...
2017: Open Heart
https://www.readbyqxmd.com/read/28408879/comparison-of-in-vivo-and-ex-vivo-mri-for-the-detection-of-structural-abnormalities-in-a-mouse-model-of-tauopathy
#5
Holly E Holmes, Nick M Powell, Da Ma, Ozama Ismail, Ian F Harrison, Jack A Wells, Niall Colgan, James M O'Callaghan, Ross A Johnson, Tracey K Murray, Zeshan Ahmed, Morten Heggenes, Alice Fisher, M Jorge Cardoso, Marc Modat, Michael J O'Neill, Emily C Collins, Elizabeth M C Fisher, Sébastien Ourselin, Mark F Lythgoe
With increasingly large numbers of mouse models of human disease dedicated to MRI studies, compromises between in vivo and ex vivo MRI must be fully understood in order to inform the choice of imaging methodology. We investigate the application of high resolution in vivo and ex vivo MRI, in combination with tensor-based morphometry (TBM), to uncover morphological differences in the rTg4510 mouse model of tauopathy. The rTg4510 mouse also offers a novel paradigm by which the overexpression of mutant tau can be regulated by the administration of doxycycline, providing us with a platform on which to investigate more subtle alterations in morphology with morphometry...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28407389/the-therapeutic-role-of-mental-health-nurses-in-psychiatric-intensive-care-a-mixed-methods-investigation-in-an-inner-city-mental-health-service
#6
Sarah MCAllister, Niall MCCrae
INTRODUCTION: Despite indications that therapeutic interaction is beneficial for patients and for nurses' job satisfaction in acute psychiatric care, research shows a small amount of nurses' time is spent on such activity. AIMS: This study investigated the actual and potential therapeutic role of the mental health nurse in psychiatric intensive care, where admission is due to violence or aggression. METHODS: In a mixed-methods concurrent triangulation design, clinician and patient activity was observed using a structured measurement tool, and qualitative interviews were conducted with four practitioners and six patients...
April 13, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28405534/improving-the-standard-of-orthopaedic-operation-documentation-using-typed-proforma-operation-notes-a-completed-audit-loop
#7
Fionn Coughlan, Prasad Ellanti, Andrew Moriarty, Nuala McAuley, Niall Hogan
INTRODUCTION: The Royal College of Surgeons (RCS) published Good Surgical Practice guidelines in 2008 and revised them in 2014. They outline the basic standard that all surgical operation notes should meet. OBJECTIVES: To retrospectively audit 57 typed orthopaedic operation notes from St. James's Hospital in Dublin (from August to November 2015) against the RCS Good Surgical Practice guidelines published in 2014. They were then compared with the department's previous audit of handwritten notes to complete the audit loop...
March 7, 2017: Curēus
https://www.readbyqxmd.com/read/28401841/positive-valence-bias-and-parent-child-relationship-security-moderate-the-association-between-early-institutional-caregiving-and-internalizing-symptoms
#8
Michelle R Vantieghem, Laurel Gabard-Durnam, Bonnie Goff, Jessica Flannery, Kathryn L Humphreys, Eva H Telzer, Christina Caldera, Jennifer Y Louie, Mor Shapiro, Niall Bolger, Nim Tottenham
Institutional caregiving is associated with significant deviations from species-expected caregiving, altering the normative sequence of attachment formation and placing children at risk for long-term emotional difficulties. However, little is known about factors that can promote resilience following early institutional caregiving. In the current study, we investigated how adaptations in affective processing (i.e., positive valence bias) and family-level protective factors (i.e., secure parent-child relationships) moderate risk for internalizing symptoms in previously institutionalized (PI) youth...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28400664/enhanced-recovery-protocol-and-hidden-blood-loss-in-patients-undergoing-total-knee-arthroplasty
#9
Rohit Dhawan, Harshadkumar Rajgor, Rathan Yarlagadda, John John, Niall M Graham
BACKGROUND: Perioperative blood loss and postoperative pain following total knee arthroplasty prevent early mobilisation of patients. The Enhanced Recovery Protocol (ERP) followed for patients in our institute aims at reducing post operative pain, blood loss and length of stay. MATERIALS AND METHODS: 50 consecutive patients that underwent ERP following total knee arthroplasty with another group of 70 patients that underwent the same surgery without ERP were compared in terms of hidden blood loss and length of hospital stay...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28391516/management-of-acute-injuries-of-the-tibiofibular-syndesmosis
#10
REVIEW
Nicholas M Fort, Amiethab A Aiyer, Jonathan R Kaplan, Niall A Smyth, Anish R Kadakia
The syndesmosis is important for ankle stability and load transmission and is commonly injured in association with ankle sprains and fractures. Syndesmotic disruption is associated with between 5 and 10% of ankle sprains and 11-20% of operative ankle fractures. Failure to recognize and appropriately treat syndesmotic disruption can portend poor functional outcomes for patients; therefore, early recognition and appropriate treatment are critical. Syndesmotic injuries are difficult to diagnose, and even when identified and treated, a slightly malreduced syndesmosis can lead to joint destruction and poor functional outcomes...
April 8, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28390400/a-comparative-study-do-clickers-increase-student-engagement-in-multidisciplinary-clinical-microbiology-teaching
#11
Niall T Stevens, Hélène McDermott, Fiona Boland, Teresa Pawlikowska, Hilary Humphreys
BACKGROUND: Audience response devices, or "clickers", have been used in the education of future healthcare professionals for several years with varying success. They have been reported to improve the learning experience by promoting engagement and knowledge retention. In 2014, our department evaluated the use of "clickers" in a newly introduced multidisciplinary approach to teaching large groups of third year medical students clinical cases developed around a microbiology theme. METHODS: Six multidisciplinary teaching sessions covering community-acquired pneumonia, tuberculosis, infective endocarditis, peritonitis, bloodstream infection with pyelonephritis and bacterial meningitis were included in the study...
April 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28387601/the-application-of-the-index-of-orthognathic-functional-treatment-need-ioftn-service-evaluation-and-impact
#12
Eamon Howard-Bowles, John Ho-A-Yun, Aman Ulhaq, Niall J P McGuinness
OBJECTIVES: (1) To undertake a service evaluation of the Index of Orthognathic Functional Treatment Need (IOFTN). (2) To determine its suitability to replace the Index of Orthodontic Treatment Need (IOTN) in the assessment of patients with dentofacial deformity. DESIGN: Laboratory- and questionnaire-based study. SETTING: UK hospital-based orthodontic department. METHODS: Cohen's Kappa was used to assess inter- and intra-operator reliability for the IOTN and the IOFTN against 30 orthognathic patients' models scored to a 'gold standard'...
April 7, 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/28384512/novel-substrates-for-the-automated-and-manual-assay-of-endo-1-4-%C3%AE-xylanase
#13
David Mangan, Claudio Cornaggia, Agnija Liadova, Niall McCormack, Ruth Ivory, Vincent A McKie, Aaron Ormerod, Barry V McCleary
endo-1,4-β-Xylanase (EC 3.2.1.8) is employed across a broad range of industries including animal feed, brewing, baking, biofuels, detergents and pulp (paper). Despite its importance, a rapid, reliable, reproducible, automatable assay for this enzyme that is based on the use of a chemically defined substrate has not been described to date. Reported herein is a new enzyme coupled assay procedure, termed the XylX6 assay, that employs a novel substrate, namely 4,6-O-(3-ketobutylidene)-4-nitrophenyl-β-4(5)-O-glucosyl-xylopentaoside...
March 4, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28365637/setting-the-record-straight-patient-recordings-of-consultations
#14
Niall O'Hara, Lily Walkergp, Kanwaljit Singh
No abstract text is available yet for this article.
April 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28365624/getting-to-the-heart-of-hypopituitarism
#15
Julie Martin-Grace, Mohamed Ahmed, Niall Mulvihill, Eoin R Feeney, Rachel K Crowley
A 53-year-old woman was diagnosed with hypopituitarism following an acute presentation with cardiac tamponade and hyponatraemia, having recently been investigated for a pericardial effusion. Secondary hypothyroidism is a rare cause of pericardial effusion and tamponade, but an important differential to consider. Management requires appropriate hormone replacement and, critically, a low threshold for commencing stress dose steroids. Clinical signs classically associated with cardiac tamponade are frequently absent in cases of tamponade due to primary and secondary hypothyroidism, and the relatively volume deplete state of secondary hypoadrenalism in hypopituitarism may further mask an evolving tamponade, as the rise in right atrial pressure is less marked even in the presence of large effusion...
April 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28362646/the-de-winter-ecg-pattern-morphology-and-accuracy-for-diagnosing-acute-coronary-occlusion-systematic-review
#16
Niall P Morris, Richard Body
The De Winter ECG pattern has been reported to indicate acute left anterior descending coronary artery occlusion and is often considered to be an 'ST elevation myocardial infarction (STEMI) equivalent'. We aimed to investigate the morphology of the 'De Winter ECG pattern' and evaluate the test characteristics of the De Winter pattern for the diagnosis of acute coronary occlusion. We identified papers through the Medline, EMBASE and COCHRANE databases and screened for bias using QUADAS-2. First, measurements were recorded from every ECG reported in the literature and aggregated...
March 30, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28344690/attitudes-of-canadian-psychiatry-residents-if-mentally-ill-awareness-barriers-to-disclosure-and-help-seeking-preferences
#17
Tariq Hassan, Tanya Tran, Nam Doan, Mir Mazhar, Neeraj Bajaj, Tariq Munshi, Niall Galbraith, Dianne Groll
BACKGROUND: The medical culture is defined by mental illness stigma, non-disclosure, and avoidance of professional treatment. Little research has explored attitudes and help-seeking behaviors of psychiatry trainees if they were to become mentally ill. METHOD: Psychiatry residents (n = 106) from training centres across Ontario, Canada completed a postal survey on their attitudes, barriers to disclosure, and help-seeking preferences in the context of hypothetically becoming mentally ill...
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28341793/bet-1-in-patients-with-suspected-acute-coronary-syndrome-does-wellens-sign-on-the-electrocardiograph-identify-critical-left-anterior-descending-artery-stenosis
#18
Niall Morris, Laura Howard
Wellens' syndrome consists of a history suggestive of an acute coronary syndrome and biphasic or deeply inverted T waves in ECG leads V2-V3. A shortcut review was carried out to establish whether this ECG pattern identifies patients with a critical left anterior descending artery stenosis. Six relevant papers were found. The clinical bottom line is that biphasic T-wave inversion in lead V2-V3 should alert the clinician to a probable critical stenosis of the left anterior descending artery.
April 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28336394/ts1cje-down-syndrome-model-mice-exhibit-environmental-stimuli-triggered-locomotor-hyperactivity-and-sociability-concurrent-with-increased-flux-through-central-dopamine-and-serotonin-metabolism
#19
Atsushi Shimohata, Keiichi Ishihara, Satoko Hattori, Hiroyuki Miyamoto, Hiromasa Morishita, Guy Ornthanalai, Matthieu Raveau, Abdul Shukkur Ebrahim, Kenji Amano, Kazuyuki Yamada, Haruhiko Sago, Satoshi Akiba, Nobuko Mataga, Niall P Murphy, Tsuyoshi Miyakawa, Kazuhiro Yamakawa
Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice...
March 20, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28331551/environmental-costs-and-benefits-of-growing-miscanthus-for-bioenergy-in-the-uk
#20
REVIEW
Jon P McCalmont, Astley Hastings, Niall P McNamara, Goetz M Richter, Paul Robson, Iain S Donnison, John Clifton-Brown
Planting the perennial biomass crop Miscanthus in the UK could offset 2-13 Mt oil eq. yr(-1), contributing up to 10% of current energy use. Policymakers need assurance that upscaling Miscanthus production can be performed sustainably without negatively impacting essential food production or the wider environment. This study reviews a large body of Miscanthus relevant literature into concise summary statements. Perennial Miscanthus has energy output/input ratios 10 times higher (47.3 ± 2.2) than annual crops used for energy (4...
March 2017: Global Change Biology. Bioenergy
keyword
keyword
33513
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"