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https://www.readbyqxmd.com/read/28742375/continuous-abdominal-negative-pressure-recruits-lungs-at-lower-distending-pressures
#1
Takeshi Yoshida, Doreen Engelberts, Gail Otulakowski, Bhushan H Katira, Martin Post, Niall D Ferguson, Laurent Brochard, Marcelo B P Amato, Brian P Kavanagh
No abstract text is available yet for this article.
July 25, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28741695/transparent-flexible-and-conductive-2d-titanium-carbide-mxene-films-with-high-volumetric-capacitance
#2
Chuanfang John Zhang, Babak Anasori, Andrés Seral-Ascaso, Sang-Hoon Park, Niall McEvoy, Aleksey Shmeliov, Georg S Duesberg, Jonathan N Coleman, Yury Gogotsi, Valeria Nicolosi
2D transition-metal carbides and nitrides, known as MXenes, have displayed promising properties in numerous applications, such as energy storage, electromagnetic interference shielding, and catalysis. Titanium carbide MXene (Ti3 C2 Tx ), in particular, has shown significant energy-storage capability. However, previously, only micrometer-thick, nontransparent films were studied. Here, highly transparent and conductive Ti3 C2 Tx films and their application as transparent, solid-state supercapacitors are reported...
July 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28739565/unusual-genitourinary-tract-activity
#3
Eoin MacCraith, Niall F Davis, James Forde
A 23-year-old woman presented to the emergency department after manually inserting foreign bodies into the urinary bladder through her urethra. A plain abdominal film of the kidneys, ureters and bladder confirmed three radio-opaque densities in the urinary bladder. She was taken to the operating room where cystourethroscopy was performed. At cystoscopy 2 'corn-on-the-cob' skewers and 1 battery were identified but were too large to be retrieved safely with a grasper through the protective sheath. The objects were grasped with a 'sponge-holding forceps' (placed alongside the cystoscope) and extracted one at a time...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28734301/communication-influence-of-external-static-and-alternating-electric-fields-on-water-from-long-time-non-equilibrium-ab-initio-molecular-dynamics
#4
Zdenek Futera, Niall J English
The response of water to externally applied electric fields is of central relevance in the modern world, where many extraneous electric fields are ubiquitous. Historically, the application of external fields in non-equilibrium molecular dynamics has been restricted, by and large, to relatively inexpensive, more or less sophisticated, empirical models. Here, we report long-time non-equilibrium ab initio molecular dynamics in both static and oscillating (time-dependent) external electric fields, therefore opening up a new vista in rigorous studies of electric-field effects on dynamical systems with the full arsenal of electronic-structure methods...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28728602/robot-assisted-training-for-the-upper-limb-after-stroke-ratuls-study-protocol-for-a-randomised-controlled-trial
#5
Helen Rodgers, Lisa Shaw, Helen Bosomworth, Lydia Aird, Natasha Alvarado, Sreeman Andole, David L Cohen, Jesse Dawson, Janet Eyre, Tracy Finch, Gary A Ford, Jennifer Hislop, Steven Hogg, Denise Howel, Niall Hughes, Hermano Igo Krebs, Christopher Price, Lynn Rochester, Elaine Stamp, Laura Ternent, Duncan Turner, Luke Vale, Elizabeth Warburton, Frederike van Wijck, Scott Wilkes
BACKGROUND: Loss of arm function is a common and distressing consequence of stroke. We describe the protocol for a pragmatic, multicentre randomised controlled trial to determine whether robot-assisted training improves upper limb function following stroke. METHODS/DESIGN: Study design: a pragmatic, three-arm, multicentre randomised controlled trial, economic analysis and process evaluation. SETTING: NHS stroke services. PARTICIPANTS: adults with acute or chronic first-ever stroke (1 week to 5 years post stroke) causing moderate to severe upper limb functional limitation...
July 20, 2017: Trials
https://www.readbyqxmd.com/read/28722417/improving-the-carrier-lifetime-of-tin-sulfide-via-prediction-and-mitigation-of-harmful-point-defects
#6
Alex Polizzotti, Alireza Faghaninia, Jeremy R Poindexter, Lea Nienhaus, Vera Steinmann, Robert L Z Hoye, Alexandre Felten, Amjad Deyine, Niall M Mangan, Juan Pablo Correa-Baena, Seong Sik Shin, Shaffiq Jaffer, Moungi G Bawendi, Cynthia Lo, Tonio Buonassisi
Tin monosulfide (SnS) is an emerging thin-film absorber material for photovoltaics. An outstanding challenge is to improve carrier lifetimes to >1 ns, which should enable >10% device efficiencies. However, reported results to date have only demonstrated lifetimes at or below 100 ps. In this study, we employ defect modeling to identify the sulfur vacancy and defects from Fe, Co, and Mo as most recombination-active. We attempt to minimize these defects in crystalline samples through high-purity, sulfur-rich growth and experimentally improve lifetimes to >3 ns, thus achieving our 1 ns goal...
July 25, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28719931/management-of-a-rare-cause-of-significant-acute-upper-gastrointestinal-bleeding-gastric-lipoma-resected-by-hybrid-endoscopic-submucosal-dissection
#7
Nikolaos Koukias, Alberto Murino, Andrea Telese, Laura Gaeta, Niall Power, Michael Rathbone, Edward J Despott
No abstract text is available yet for this article.
July 18, 2017: Endoscopy
https://www.readbyqxmd.com/read/28716717/big-gaba-edited-mr-spectroscopy-at-24-research-sites
#8
Mark Mikkelsen, Peter B Barker, Pallab K Bhattacharyya, Maiken K Brix, Pieter F Buur, Kim M Cecil, Kimberly L Chan, David Y-T Chen, Alexander R Craven, Koen Cuypers, Michael Dacko, Niall W Duncan, Ulrike Dydak, David A Edmondson, Gabriele Ende, Lars Ersland, Fei Gao, Ian Greenhouse, Ashley D Harris, Naying He, Stefanie Heba, Nigel Hoggard, Tun-Wei Hsu, Jacobus F A Jansen, Alayar Kangarlu, Thomas Lange, R Marc Lebel, Yan Li, Chien-Yuan E Lin, Jy-Kang Liou, Jiing-Feng Lirng, Feng Liu, Ruoyun Ma, Celine Maes, Marta Moreno-Ortega, Scott O Murray, Sean Noah, Ralph Noeske, Michael D Noseworthy, Georg Oeltzschner, James J Prisciandaro, Nicolaas A J Puts, Timothy P L Roberts, Markus Sack, Napapon Sailasuta, Muhammad G Saleh, Michael-Paul Schallmo, Nicholas Simard, Stephan P Swinnen, Martin Tegenthoff, Peter Truong, Guangbin Wang, Iain D Wilkinson, Hans-Jörg Wittsack, Hongmin Xu, Fuhua Yan, Chencheng Zhang, Vadim Zipunnikov, Helge J Zöllner, Richard A E Edden
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid (GABA) in the human brain. Its increasing popularity has been aided by improvements in scanner hardware and acquisition methodology, as well as by broader access to pulse sequences that can selectively detect GABA, in particular J-difference spectral editing sequences. Nevertheless, implementations of GABA-edited MRS remain diverse across research sites, making comparisons between studies challenging...
July 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28714688/design-of-a-chemical-probe-for-the-bromodomain-and-plant-homeodomain-finger-containing-brpf-family-of-proteins
#9
Niall Igoe, Elliott D Bayle, Cynthia Tallant, Oleg Fedorov, Julia C Meier, Pavel Savitsky, Catherine Rogers, Yannick Morias, Sarah Scholze, Helen Boyd, Danen Cunoosamy, David M Andrews, Anne Cheasty, Paul E Brennan, Susanne Müller, Stefan Knapp, Paul V Fish
The bromodomain and PHD finger-containing (BRPF) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Here we describe NI-57 (16) as new pan-BRPF chemical probe of the bromodomain (BRD) of the BRPFs. Inhibitor 16 preferentially bound the BRD of BRPF1 and BRD1 over BRPF3, whereas binding to BRD9 was weaker. 16 has excellent selectivity over non-class IV BRD proteins. Target engagement of BRPF1B and BRD1 with 16 was demonstrated in nanoBRET and FRAP assays...
July 17, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28713439/predicting-future-biomass-yield-in-miscanthus-using-the-carbohydrate-metabolic-profile-as-a-biomarker
#10
Anne L Maddison, Anyela Camargo-Rodriguez, Ian M Scott, Charlotte M Jones, Dafydd M O Elias, Sarah Hawkins, Alice Massey, John Clifton-Brown, Niall P McNamara, Iain S Donnison, Sarah J Purdy
In perennial energy crop breeding programmes, it can take several years before a mature yield is reached when potential new varieties can be scored. Modern plant breeding technologies have focussed on molecular markers, but for many crop species, this technology is unavailable. Therefore, prematurity predictors of harvestable yield would accelerate the release of new varieties. Metabolic biomarkers are routinely used in medicine, but they have been largely overlooked as predictive tools in plant science. We aimed to identify biomarkers of productivity in the bioenergy crop, Miscanthus, that could be used prognostically to predict future yields...
July 2017: Global Change Biology. Bioenergy
https://www.readbyqxmd.com/read/28711047/global-density-fluctuations-in-methane-clathrate-hydrates-in-externally-applied-electromagnetic-fields
#11
Conor J Waldron, Niall J English
Non-equilibrium molecular-dynamics simulations of bulk methane clathrate hydrates have been conducted in a range of externally applied electromagnetic (e/m) fields. Studies into frequencies of system(or "global")-mass-density fluctuations showed that these clathrates have three major modes: the dominant one is attributable to water molecules' librations and occurs at 720 cm(-1), regardless of any applied e/m fields. One of the more minor system-density fluctuations arises at 10-12 cm(-1) and is caused by the propagation of local-density fluctuations; again, this is independent of e/m fields...
July 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28710666/mediators-of-physical-activity-adherence-results-from-an-action-control-intervention-in-couples
#12
Corina Berli, Gertraud Stadler, Patrick E Shrout, Niall Bolger, Urte Scholz
BACKGROUND: Behavior change interventions targeting self-regulation skills have generally shown promising effects. However, the psychological working mechanisms remain poorly understood. PURPOSE: We examined theory-based mediators of a randomized controlled trial in couples targeting action control (i.e., continuously monitoring and evaluating an ongoing behavior). Self-reported action control was tested as the main mediating mechanism of physical activity adherence, and in addition self-efficacy and received social support from the partner...
July 14, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28708901/sex-specific-enhancement-of-palatability-driven-feeding-in-adolescent-rats
#13
Andrew T Marshall, Angela T Liu, Niall P Murphy, Nigel T Maidment, Sean B Ostlund
It has been hypothesized that brain development during adolescence perturbs reward processing in a way that may ultimately contribute to the risky decision making associated with this stage of life, particularly in young males. To investigate potential reward dysfunction during adolescence, Experiment 1 examined palatable fluid intake in rats as a function of age and sex. During a series of twice-weekly test sessions, non-food-deprived rats were given the opportunity to voluntarily consume a highly palatable sweetened condensed milk (SCM) solution...
2017: PloS One
https://www.readbyqxmd.com/read/28704643/multidisciplinary-training-of-cancer-specialists-in-europe
#14
Kim Benstead, Nazim Serdar Turhal, Niall O'Higgins, Lynda Wyld, Magdalena Czarnecka-Operacz, Harald Gollnick, Peter Naredi, Jesper Grau Eriksen
The best care for patients with cancer is most likely to be achieved when decisions about diagnosis, staging and treatment are made at multidisciplinary and multiprofessional meetings, preferably when all the professional expertise relevant to the patient's condition is gathered together. Questionnaires were sent to National Societies of Radiation Oncology and Medical Oncology concerning similarities and differences in training programs and multidisciplinary care in member states in Europe. Results indicated wide variation in training systems and practice...
July 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28698975/exploring-the-impact-of-feedback-on-prescribing-error-rates-a-pilot-study
#15
Michael Lloyd, Simon David Watmough, Sarah Victoria O'Brien, Kevin Hardy, Niall Furlong
Background Prescribing errors are prevalent in hospital settings with feedback identified as one potential error reduction strategy. Hospital pharmacists work alongside prescribers at ward level and are credible facilitators of prescribing error feedback. A formalised programme of pharmacist-led prescribing error feedback was designed and implemented Objective To determine the impact of the feedback intervention on prescribing error rates. Method Prospective prescribing audits were undertaken at baseline for control (n = 11) and intervention group (n = 10) prescribers...
July 11, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28698470/real-time-amperometric-recording-of-extracellular-h%C3%A2-o%C3%A2-in-the-brain-of-immunocompromised-mice-an-in-vitro-ex-vivo-and-in-vivo-characterisation-study
#16
Caroline H Reid, Niall J Finnerty
We detail an extensive characterisation study on a previously described dual amperometric H₂O₂ biosensor consisting of H₂O₂ detection (blank) and degradation (catalase) electrodes. In vitro investigations demonstrated excellent H₂O₂ sensitivity and selectivity against the interferent, ascorbic acid. Ex vivo studies were performed to mimic physiological conditions prior to in vivo deployment. Exposure to brain tissue homogenate identified reliable sensitivity and selectivity recordings up to seven days for both blank and catalase electrodes...
July 8, 2017: Sensors
https://www.readbyqxmd.com/read/28693677/directed-panspermia-a-21st-century-perspective
#17
Roy D Sleator, Niall Smith
Applying 21st century technology to the design and development of a hypothetical extra-terrestrial colonisation programme, we reimagine 'directed panspermia' from the perspective of Crick and Orgel's 'technological society', 44 years after the publication of their original landmark paper.
May 1, 2017: Science Progress
https://www.readbyqxmd.com/read/28692755/enabling-flexible-heterostructures-for-li-ion-battery-anodes-based-on-nanotube-and-liquid-phase-exfoliated-2d-gallium-chalcogenide-nanosheet-colloidal-solutions
#18
Chuanfang John Zhang, Sang-Hoon Park, Oskar Ronan, Andrew Harvey, Andrés Seral-Ascaso, Zifeng Lin, Niall McEvoy, Conor S Boland, Nina C Berner, Georg S Duesberg, Patrick Rozier, Jonathan N Coleman, Valeria Nicolosi
2D metal chalcogenide (MC) nanosheets (NS) have displayed high capacities as lithium-ion battery (LiB) anodes. Nevertheless, their complicated synthesis routes coupled with low electronic conductivity greatly limit them as promising LiB electrode material. Here, this work reports a facile single-walled carbon nanotube (SWCNT) percolating strategy for efficiently maximizing the electrochemical performances of gallium chalcogenide (GaX, X = S or Se). Multiscaled flexible GaX NS/SWCNT heterostructures with abundant voids for Li(+) diffusion are fabricated by embedding the liquid-exfoliated GaX NS matrix within a SWCNT-percolated network; the latter improves the electron transport and ion diffusion kinetics as well as maintains the mechanical flexibility...
July 10, 2017: Small
https://www.readbyqxmd.com/read/28680667/the-impact-of-induced-anxiety-on-affective-response-inhibition
#19
Jessica Aylward, Vincent Valton, Franziska Goer, Anahit Mkrtchian, Níall Lally, Sarah Peters, Tarun Limbachya, Oliver J Robinson
Studying the effects of experimentally induced anxiety in healthy volunteers may increase our understanding of the mechanisms underpinning anxiety disorders. Experimentally induced stress (via threat of unpredictable shock) improves accuracy at withholding a response on the sustained attention to response task (SART), and in separate studies improves accuracy to classify fearful faces, creating an affective bias. Integrating these findings, participants at two public science engagement events (n = 46, n = 55) were recruited to explore the effects of experimentally induced stress on an affective version of the SART...
June 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28678778/an-immunogenic-personal-neoantigen-vaccine-for-patients-with-melanoma
#20
Patrick A Ott, Zhuting Hu, Derin B Keskin, Sachet A Shukla, Jing Sun, David J Bozym, Wandi Zhang, Adrienne Luoma, Anita Giobbie-Hurder, Lauren Peter, Christina Chen, Oriol Olive, Todd A Carter, Shuqiang Li, David J Lieb, Thomas Eisenhaure, Evisa Gjini, Jonathan Stevens, William J Lane, Indu Javeri, Kaliappanadar Nellaiappan, Andres M Salazar, Heather Daley, Michael Seaman, Elizabeth I Buchbinder, Charles H Yoon, Maegan Harden, Niall Lennon, Stacey Gabriel, Scott J Rodig, Dan H Barouch, Jon C Aster, Gad Getz, Kai Wucherpfennig, Donna Neuberg, Jerome Ritz, Eric S Lander, Edward F Fritsch, Nir Hacohen, Catherine J Wu
Effective anti-tumour immunity in humans has been associated with the presence of T cells directed at cancer neoantigens, a class of HLA-bound peptides that arise from tumour-specific mutations. They are highly immunogenic because they are not present in normal tissues and hence bypass central thymic tolerance. Although neoantigens were long-envisioned as optimal targets for an anti-tumour immune response, their systematic discovery and evaluation only became feasible with the recent availability of massively parallel sequencing for detection of all coding mutations within tumours, and of machine learning approaches to reliably predict those mutated peptides with high-affinity binding of autologous human leukocyte antigen (HLA) molecules...
July 13, 2017: Nature
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