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https://www.readbyqxmd.com/read/28526363/autonomous-motivation-and-fruit-vegetable-intake-in-parent-adolescent-dyads
#1
Laura A Dwyer, Niall Bolger, Jean-Philippe Laurenceau, Heather Patrick, April Y Oh, Linda C Nebeling, Erin Hennessy
INTRODUCTION: Autonomous motivation (motivation to engage in a behavior because of personal choice, interest, or value) is often associated with health behaviors. The present study contributes to research on motivation and eating behaviors by examining (1) how autonomous motivation is correlated within parent-adolescent dyads and (2) whether parent- and adolescent-reported autonomous motivation predicts the parent-adolescent correlation in fruit and vegetable (FV) intake frequency. METHODS: Data were drawn from the Family Life, Activity, Sun, Health, and Eating (FLASHE) Study, a cross-sectional U...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28501873/comparisons-of-risk-factors-for-intracerebral-hemorrhage-versus-ischemic-stroke-in-chinese-patients
#2
Chung-Fen Tsai, Jiann-Shing Jeng, Niall Anderson, Cathie L M Sudlow
BACKGROUND: Chinese populations have a higher stroke incidence, a higher proportion of intracerebral hemorrhage (ICH), and a lower proportion of ischemic stroke (IS) as compared with white populations. The reasons are not fully understood. METHODS: To evaluate the differences of major risk factors between ICH and IS in Chinese stroke patients, we analysed acute ICH and IS patients consecutively recruited in National Taiwan University Hospital Stroke Registry from 2006 to 2011...
May 13, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28500125/acute-urinary-retention-and-constipation-precipitated-by-herpes-zoster-infection
#3
Eoin MacCraith, Niall F Davis, Kilian Walsh
A 76-year-old man presented to the emergency department complaining of acute urinary retention (AUR) and severe constipation. His recent medical history included 4 days of treatment in the community for gluteal herpes zoster with famciclovir. A transurethral catheter was passed and the patient completed a full course of famciclovir with resolution of constipation. The patient's catheter was successfully removed 3 weeks after his presentation. We report on the clinical presentation and management of an unusual case of AUR and constipation caused by a zoster viral infection of the S2-S4 dermatome...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28500033/proteomic-responses-to-elevated-ocean-temperature-in-ovaries-of-the-ascidian-ciona-intestinalis
#4
Chelsea E Lopez, Hannah C Sheehan, David A Vierra, Paul A Azzinaro, Thomas H Meedel, Niall G Howlett, Steven Q Irvine
Ciona intestinalis, a common sea squirt, exhibits lower reproductive success at the upper extreme of water temperatures it experiences in coastal New England. In order to understand the changes in protein expression associated with elevated temperatures, and possible response to global temperature change, we reared C. intestinalis from embryos to adults at 18°C (a temperature at which they reproduce normally at our collection site in Rhode Island) and 22°C (the upper end of the local temperature range). We then dissected ovaries from animals at each temperature, extracted protein, and measured proteomic levels using shotgun mass spectrometry (LC-MS/MS)...
May 12, 2017: Biology Open
https://www.readbyqxmd.com/read/28495762/draft-genome-sequences-of-25-listeria-monocytogenes-isolates-associated-with-human-clinical-listeriosis-in-ireland
#5
Amy O'Callaghan, Amber Hilliard, Ciara A Morgan, Eamonn P Culligan, Dara Leong, Niall DeLappe, Colin Hill, Kieran Jordan, Martin Cormican, Cormac G M Gahan
Listeria monocytogenes is a Gram-positive opportunistic pathogen that is the causative agent of listeriosis. Here, we report the draft genome sequences of 25 L. monocytogenes strains isolated from patients with clinical listeriosis in the Republic of Ireland between 2013 and 2015.
May 11, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28493130/a-bioinformatics-pipeline-for-the-identification-of-cho-cell-differential-gene-expression-from-rna-seq-data
#6
Craig Monger, Krishna Motheramgari, John McSharry, Niall Barron, Colin Clarke
In recent years, the publication of genome sequences for the Chinese hamster and Chinese hamster ovary (CHO) cell lines has facilitated study of these biopharmaceutical cell factories with unprecedented resolution. Our understanding of the CHO cell transcriptome, in particular, has rapidly advanced through the application of next-generation sequencing (NGS) technology to characterize RNA expression (RNA-Seq). In this chapter, we present a computational pipeline for the analysis of CHO cell RNA-Seq data from the Illumina platform to identify differentially expressed genes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28493125/conditional-knockdown-of-endogenous-micrornas-in-cho-cells-using-tet-on-sandi-sponge-vectors
#7
Alan Costello, Nga Lao, Martin Clynes, Niall Barron
MicroRNAs (miRNAs) are small, noncoding RNAs of about 22 nucleotides in length and have proven to be useful targets for genetic modifications for desirable phenotype in the biotech industry. The use of constitutively expressed "miRNA sponge" vectors in which multiple, tandem miRNA binding sites containing transcripts are transcriptionally regulated by a constitutive promoter for down regulating the levels of endogenous microRNAs in Chinese hamster ovary (CHO) cells has shown to be more advantageous than using synthetic antisense oligonucleotides...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28491898/a-cross-sectional-population-based-investigation-into-behavioral-change-in-amyotrophic-lateral-sclerosis-subphenotypes-staging-cognitive-predictors-and-survival
#8
Tom Burke, Marta Pinto-Grau, Katie Lonergan, Peter Bede, Meabhdh O'Sullivan, Mark Heverin, Alice Vajda, Russell L McLaughlin, Niall Pender, Orla Hardiman
OBJECTIVE: Amyotrophic Lateral Sclerosis (ALS) is a clinically heterogeneous neurodegenerative disorder associated with cognitive and behavioral impairment. The primary aim of this study was to identify behavioral subphenotypes in ALS using a custom designed behavioral assessment tool (Beaumont Behavioural Inventory, BBI). Secondary aims were to (1) investigate the predictive nature of cognitive assessment on behavioral change, (2) report the behavioral profile associated with the C9orf72 expansion, (3) categorize behavioral change through disease staging, and (4) to investigate the relationship between cross-sectional behavioral classification and survival...
May 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28488925/strategies-to-address-the-shortcomings-of-commonly-used-advanced-chronic-heart-failure-descriptors-to-improve-recruitment-in-palliative-care-research-a-parallel-mixed-methods-feasibility-study
#9
Pauline M Kane, Fliss Em Murtagh, Karen R Ryan, Mary Brice, Niall G Mahon, Brendan McAdam, Regina McQuillan, Geraldine O'Gara, Caroline Raleigh, Cecelia Tracey, Christine Howley, Irene J Higginson, Barbara A Daveson
BACKGROUND: Recruitment challenges contribute to the paucity of palliative care research with advanced chronic heart failure patients. AIM: To describe the challenges and outline strategies of recruiting advanced chronic heart failure patients. DESIGN: A feasibility study using a pre-post uncontrolled design. SETTING: Advanced chronic heart failure patients were recruited at two nurse-led chronic heart failure disease management clinics in Ireland Results: Of 372 patients screened, 81 were approached, 38 were recruited (46...
May 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28486256/one-year-clinical-outcomes-in-an-ibd-cohort-who-have-previously-had-anti-tnfa-trough-and-antibody-levels-assessed
#10
Donal Tighe, Barry Hall, Shivashini Kirthi Jeyarajah, Sinead Smith, Niall Breslin, Barbara Ryan, Deirdre McNamara
BACKGROUND: Loss of response (LOR) is a big concern for anti-TNFa therapies in inflammatory bowel disease. Immunomonitoring may be useful to optimize response rates and overcome secondary LOR. METHODS: This was an observational retrospective cohort study of a group of patients with inflammatory bowel disease on infliximab (IFX) and adalimumab (ADA) who had anti-TNFa trough and antibody levels measured, during maintenance phase of treatment. Anti-TNFa trough and antibody levels were measured using standard enzyme-linked immunosorbent assay techniques...
May 5, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28475631/a-systems-level-model-reveals-that-1-2-propanediol-utilization-microcompartments-enhance-pathway-flux-through-intermediate-sequestration
#11
Christopher M Jakobson, Danielle Tullman-Ercek, Marilyn F Slininger, Niall M Mangan
The spatial organization of metabolism is common to all domains of life. Enteric and other bacteria use subcellular organelles known as bacterial microcompartments to spatially organize the metabolism of pathogenicity-relevant carbon sources, such as 1,2-propanediol. The organelles are thought to sequester a private cofactor pool, minimize the effects of toxic intermediates, and enhance flux through the encapsulated metabolic pathways. We develop a mathematical model of the function of the 1,2-propanediol utilization microcompartment of Salmonella enterica and use it to analyze the function of the microcompartment organelles in detail...
May 5, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28470797/screening-for-mismatch-repair-deficiency-in-colorectal-cancer-data-from-three-academic-medical-centers
#12
Grainne M O'Kane, Éanna Ryan, Terri P McVeigh, Ben Creavin, John Mp Hyland, Diarmuid P O'Donoghue, Denise Keegan, Robert Geraghty, Delia Flannery, Carmel Nolan, Emily Donovan, Brian J Mehigan, Paul McCormick, Cian Muldoon, Michael Farrell, Conor Shields, Niall Mulligan, Michael John Kennedy, Andrew J Green, Desmond C Winter, Padraic MacMathuna, Kieran Sheahan, David J Gallagher
Reflex immunohistochemistry (rIHC) for mismatch repair (MMR) protein expression can be used as a screening tool to detect Lynch Syndrome (LS). Increasingly the mismatch repair-deficient (dMMR) phenotype has therapeutic implications. We investigated the pattern and consequence of testing for dMMR in three Irish Cancer Centres (CCs). CRC databases were analyzed from January 2005-December 2013. CC1 performs IHC upon physician request, CC2 implemented rIHC in November 2008, and CC3 has been performing rIHC since 2004...
May 3, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28466747/an-exploratory-study-of-the-extent-of-social-inclusion-among-people-with-psychosis-and-psychotic-related-conditions
#13
Niall Turner, Lisa Ferguson, Michele Hill, Tara Nesbitt, Eadbhard O'Callaghan, Paul O'Mahony, Mary Clarke
BACKGROUND: Understanding social inclusion among at-risk populations will deepen our understanding of their specific needs. AIM: This study explored the level of social inclusion among people with psychotic-related conditions using a standardised interview. METHOD: The Social Inclusion Interview Schedule was used in two research projects. People with psychosis participated in both studies and had been recruited as part of an Irish programme of research on psychotic conditions...
May 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28463605/comparison-of-poly-l-lactide-co-%C3%AE%C2%B5-caprolactone-and-poly-trimethylene-carbonate-membranes-for-urethral-regeneration-an-in-vitro-and-in-vivo-study
#14
Reetta Sartoneva, Panu Nordback, Suvi Haimi, Dirk W Grijpma, Kalle Lehto, Rooney Niall, Riitta Seppänen-Kaijansinkko Md Dds PhD, Susanna Miettinen, Tuija Lahdes-Vasama
Urethral defects are normally reconstructed using patient's own genital tissue; however, in severe cases, additional grafts are needed. We studied the suitability of poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(trimethylene carbonate) (PTMC) membranes for urethral reconstruction in vivo. Further, the compatibility of the materials was evaluated in vitro with human urothelial cells (hUC). The attachment and viability of hUCs and the expression of different urothelial cell markers (Cytokeratin 7, 8, 19 and Uroplakin Ia, Ib and III) were studied after in vitro cell culture on PLCL and PTMC...
May 2, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28461332/a-bacteroidetes-locus-dedicated-to-fungal-1-6-%C3%AE-glucan-degradation-unique-substrate-conformation-drives-specificity-of-the-key-endo-1-6-%C3%AE-glucanase
#15
Max J Temple, Fiona Cuskin, Arnaud Baslé, Niall Hickey, Gaetano Speciale, Spencer J Williams, Harry J Gilbert, Elisabeth C Lowe
Glycans are major nutrients available to the human gut microbiota (HGM). The Bacteroides are generalist glycan degraders and this function is mediated largely by polysaccharide utilization loci (PULs). The genomes of several Bacteroides species contain a PUL, PUL1,6-beta;-glucan, that was predicted to target mixed linked plant 1,3;1,4-beta-glucans. To test this hypothesis we characterized the proteins encoded by this locus in Bacteroides thetaiotaomicron, a member of the HGM. We show here that PUL1,6-β-glucan does not orchestrate the degradation of a plant polysaccharide but targets a fungal cell wall glycan, 1,6-beta-glucan, which is a growth substrate for the bacterium...
May 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28461268/formulation-and-characterisation-of-dissolving-microneedles-for-the-transdermal-delivery-of-therapeutic-peptides
#16
Colin Dillon, Helen Hughes, Niall J O'Reilly, Peter McLoughlin
The highly effective barrier properties of the stratum corneum (SC) limit the application of transdermal delivery to relatively small, lipophilic molecules. Microneedles (MNs) however, offer a route to effectively deliver a wide range of pharmaceuticals through the skin, bypassing the SC in a non-invasive and pain-free manner. This study presents a dissolving MN system composed of polyvinylpyrrolidone (PVP) and trehalose to encapsulate active pharmaceutical peptides within the MN matrix. Rapid systemic delivery is then achieved once the needles have penetrated the SC and dissolved in the interstitial fluid of the skin...
April 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28459336/an-official-american-thoracic-society-european-society-of-intensive-care-medicine-society-of-critical-care-medicine-clinical-practice-guideline-mechanical-ventilation-in-adult-patients-with-acute-respiratory-distress-syndrome
#17
Eddy Fan, Lorenzo Del Sorbo, Ewan C Goligher, Carol L Hodgson, Laveena Munshi, Allan J Walkey, Neill K J Adhikari, Marcelo B P Amato, Richard Branson, Roy G Brower, Niall D Ferguson, Ognjen Gajic, Luciano Gattinoni, Dean Hess, Jordi Mancebo, Maureen O Meade, Daniel F McAuley, Antonio Pesenti, V Marco Ranieri, Gordon D Rubenfeld, Eileen Rubin, Maureen Seckel, Arthur S Slutsky, Daniel Talmor, B Taylor Thompson, Hannah Wunsch, Elizabeth Uleryk, Jan Brozek, Laurent J Brochard
BACKGROUND: This document provides evidence-based clinical practice guidelines on the use of mechanical ventilation in adult patients with acute respiratory distress syndrome (ARDS). METHODS: A multidisciplinary panel conducted systematic reviews and metaanalyses of the relevant research and applied Grading of Recommendations, Assessment, Development, and Evaluation methodology for clinical recommendations. RESULTS: For all patients with ARDS, the recommendation is strong for mechanical ventilation using lower tidal volumes (4-8 ml/kg predicted body weight) and lower inspiratory pressures (plateau pressure < 30 cm H2O) (moderate confidence in effect estimates)...
May 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28446486/delayed-diagnosis-of-pulmonary-tuberculosis-in-a-13-year-old-malawian-boy
#18
Niall Johnston, Nichola Sandys
Childhood tuberculosis (TB) is a significant global health burden. There are more than 1 million new cases of childhood TB annually. Despite this, many national TB control programs largely focus on identification and treatment of smear positive adults. Early case detection is essential if childhood TB is to be controlled and eradicated.Delayed diagnosis of TB is associated with more advanced disease and worse treatment outcomes. Younger children who go undiagnosed for long periods are at risk of developing severe pulmonary and extrapulmonary disease, such as meningitis...
April 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28442226/female-athlete-triad-at-breaking-point
#19
Martin Duignan, Niall O'Connor
No abstract text is available yet for this article.
April 22, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28437750/becoming-comfortable-with-my-epilepsy-strategies-that-patients-use-in-the-journey-from-diagnosis-to-acceptance-and-disclosure
#20
Sinead Pembroke, Agnes Higgins, Niall Pender, Naomi Elliott
OBJECTIVE: Proponents of resilience theory have highlighted the importance of understanding the processes of resilience. The objective of the study was to explore how people with epilepsy reach a stage of being comfortable with their epilepsy. Identifying the processes used is important to developing effective self-management for people who are newly diagnosed with epilepsy. METHOD: A grounded theory approach involving forty-nine consenting adult people with epilepsy (18 years and over), was used to explore their first-hand experiences of coming to terms with their epilepsy...
April 19, 2017: Epilepsy & Behavior: E&B
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