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Stefan Wagner, Chanyoung Yim, Niall McEvoy, Satender Kataria, Volkan Yokaribas, Agnieszka Kuc, Stephan Pindl, Claus-Peter Fritzen, Thomas Heine, Georg S Duesberg, Max C Lemme
Two-dimensional (2D) layered materials are ideal for micro- and nanoelectromechanical systems (MEMS/NEMS) due to their ultimate thinness. Platinum diselenide (PtSe2 ), an exciting and unexplored 2D transition metal dichalcogenides (TMD) material, is particularly interesting because its scalable and low temperature growth process is compatible with silicon technology. Here, we explore the potential of thin PtSe2 films as electromechanical piezoresistive sensors. All experiments have been conducted with semi-metallic PtSe2 films grown by thermally assisted conversion of Pt at a CMOS-compatible temperature of 400°C...
May 16, 2018: Nano Letters
C Wade Ross, Lara Prihodko, Julius Anchang, Sanath Kumar, Wenjie Ji, Niall P Hanan
Hydrologic soil groups (HSGs) are a fundamental component of the USDA curve-number (CN) method for estimation of rainfall runoff; yet these data are not readily available in a format or spatial-resolution suitable for regional- and global-scale modeling applications. We developed a globally consistent, gridded dataset defining HSGs from soil texture, bedrock depth, and groundwater. The resulting data product-HYSOGs250m-represents runoff potential at 250 m spatial resolution. Our analysis indicates that the global distribution of soil is dominated by moderately high runoff potential, followed by moderately low, high, and low runoff potential...
May 15, 2018: Scientific Data
Niall McCrae, Jonathan Portes
In a referendum on 23nd June 2016 the people of the UK voted to leave the European Union (EU). The phenomenon known as Brexit did not come out of nowhere: according to Clarke, Whiteley and Goodwin (2017), it marked a culmination of social and political trends emerging over many years. Moreover, there is resonance far beyond the UK, with tensions between an increasingly globalised society and national autonomy, between young and old, and between 'liberals' and 'authoritarians' (Ford & Goodwin, 2014). Such forces underlie not just Brexit, but also, in different context and in different forms, the election of Donald Trump and the rise of populist parties in Europe...
May 13, 2018: Journal of Advanced Nursing
Kevin P Gaughan, Usman Haroon, Niall F Davis, Ponnusamy Mohan
The incidence of urothelial carcinoma (UC; formerly transitional cell carcinoma) is higher among renal transplant recipients compared with the general population. Upper urinary tract UC (UUT-UC) of allograft urothelium is a rare event with approximately 40 cases reported in the literature. Herein, we describe the clinical presentation and management of UUT-UC in a transplant ureter 10 years after deceased donor kidney transplantation.
May 12, 2018: BMJ Case Reports
Jennifer W Evans, Níall Lally, Li An, Ningzhi Li, Allison C Nugent, Dipavo Banerjee, Sam L Snider, Jun Shen, Jonathan P Roiser, Carlos A Zarate
The glutamatergic modulator ketamine has striking and rapid antidepressant effects in major depressive disorder (MDD), but its mechanism of action remains unknown. Proton magnetic resonance spectroscopy (1H-MRS) is the only non-invasive method able to directly measure glutamate levels in vivo; in particular, glutamate and glutamine metabolite concentrations are separable by 1H-MRS at 7T. This double-blind, placebo-controlled, crossover study that included 1 H-MRS scans at baseline and at 24 h post ketamine and post-placebo infusions sought to determine glutamate levels in the pregenual anterior cingulate (pgACC) of 20 medication-free MDD subjects and 17 healthy volunteers (HVs) 24 h post ketamine administration, and to evaluate any other measured metabolite changes, correlates, or predictors of antidepressant response...
April 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Bryan P Traynor, Eoghan Pomeroy, Dorothy Niall
Purple urine bag syndrome (PUBS) is a rare and striking manifestation associated with urinary tract infection involving bright purple discoloration of the lining and tubing of a urinary catheter bag. We present the interesting case of a 90-year-old female patient who developed PUBS and include a review of the relevant literature to date. Uniquely, in this case, PUBS acts as an important clinical sign in supporting the diagnosis of urinary tract infection in a high-risk patient.
November 2017: Oxford Medical Case Reports
Petra Zur Lage, Panagiota Stefanopoulou, Katarzyna Styczynska-Soczka, Niall Quinn, Girish Mali, Alex von Kriegsheim, Pleasantine Mill, Andrew P Jarman
The massive dynein motor complexes that drive ciliary and flagellar motility require cytoplasmic preassembly, a process requiring dedicated dynein assembly factors (DNAAFs). How DNAAFs interact with molecular chaperones to control dynein assembly is not clear. By analogy with the well-known multifunctional HSP90-associated cochaperone, R2TP, several DNAAFs have been suggested to perform novel R2TP-like functions. However, the involvement of R2TP itself (canonical R2TP) in dynein assembly remains unclear. Here we show that in Drosophila melanogaster , the R2TP-associated factor, Wdr92, is required exclusively for axonemal dynein assembly, likely in association with canonical R2TP...
May 9, 2018: Journal of Cell Biology
Amanda Townsend, Niall C Tebbutt, Christos S Karapetis, Pamela Cooper, Nimit Singhal, Sue J Yeend, Louise Pirc, Rohit Joshi, Jennifer Elizabeth Hardingham, Timothy Price
PURPOSE: Inhibition of mTOR in addition to EGFR may overcome resistance to EGFR inhibitors in metastatic colorectal cancer (mCRC). This phase Ib/II study evaluated the safety and efficacy of the combination of irinotecan, panitumumab and everolimus. EXPERIMENTAL DESIGN: Patients with KRAS exon 2 WT mCRC following failure of fluoropyrimidine based therapy received IV irinotecan and panitumumab every 2 weeks, and everolimus orally throughout a 14 day cycle. The primary endpoint of the phase II study was response rate (RR)...
May 8, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Maura Costello, Mark Fleharty, Justin Abreu, Yossi Farjoun, Steven Ferriera, Laurie Holmes, Brian Granger, Lisa Green, Tom Howd, Tamara Mason, Gina Vicente, Michael Dasilva, Wendy Brodeur, Timothy DeSmet, Sheila Dodge, Niall J Lennon, Stacey Gabriel
BACKGROUND: Here we present an in-depth characterization of the mechanism of sequencer-induced sample contamination due to the phenomenon of index swapping that impacts Illumina sequencers employing patterned flow cells with Exclusion Amplification (ExAmp) chemistry (HiSeqX, HiSeq4000, and NovaSeq). We also present a remediation method that minimizes the impact of such swaps. RESULTS: Leveraging data collected over a two-year period, we demonstrate the widespread prevalence of index swapping in patterned flow cell data...
May 8, 2018: BMC Genomics
Sarala M Wimalaratne, Nick Juty, John Kunze, Greg Janée, Julie A McMurry, Niall Beard, Rafael Jimenez, Jeffrey S Grethe, Henning Hermjakob, Maryann E Martone, Tim Clark
Most biomedical data repositories issue locally-unique accessions numbers, but do not provide globally unique, machine-resolvable, persistent identifiers for their datasets, as required by publishers wishing to implement data citation in accordance with widely accepted principles. Local accessions may however be prefixed with a namespace identifier, providing global uniqueness. Such "compact identifiers" have been widely used in biomedical informatics to support global resource identification with local identifier assignment...
May 8, 2018: Scientific Data
Eoghan Pomeroy, Fergal Macnamara, Evelyn Murphy, Niall McGoldrick, Anant Mahapatra, Nasir Awan
BACKGROUND: Failure to restore femoral offset in metal on polyethylene total hip arthroplasty (THA) causes polyethylene wear and aseptic loosening. To our knowledge, no study to date has investigated the relationship between femoral offset and wear in metal-on-metal (MOM) THA. AIMS: In this study, we investigated the relationship between femoral offset and wear by measuring circulating metal ion levels in MOM THA. METHODS: In this retrospective study, we identified patients who had undergone MOM THA with the ASR XL system (DePuy International Ltd...
May 7, 2018: Irish Journal of Medical Science
Niall A Smyth, Amiethab A Aiyer
Hallux valgus is a common pathology of the foot and ankle. Surgical correction of the condition has been described as early as 1836. Since then, numerous different surgical techniques have been documented in the literature. One of the explanations as to why there are so many different surgeries for hallux valgus is the variety of etiologies attributed to causing the condition. This article discusses the etiologies associated with hallux valgus and describes a few of the surgeries commonly used to treat the deformity...
June 2018: Foot and Ankle Clinics
Satu Baylan, Meigan McGinlay, Maxine MacDonald, Jake Easto, Breda Cullen, Caroline Haig, Stewart W Mercer, Heather Murray, Terence J Quinn, David Stott, Niall M Broomfield, Ciara Stiles, Jonathan J Evans
Existing research evidence suggests that both music listening and mindfulness interventions may have beneficial effects on mood and cognition poststroke. This mixed-methods study, nested within a pilot randomized controlled trial investigating the feasibility and acceptability of combining music listening and brief mindfulness training poststroke, explored study participants' experiences of engaging in the interventions. Fifty-six stroke survivors who were randomized to receive an 8-week intervention of mindful music listening (n = 15), music listening (n = 21), or audiobook listening (n = 20, control) using self-selected material participated in a postintervention individual semistructured interview with a researcher not involved in their intervention delivery...
May 4, 2018: Annals of the New York Academy of Sciences
Niall Gilliland, Natalie Catherwood, Shaouyn Chen, Peter Browne, Jacob Wilson, Helena Burden
Introduction and aims: Concerns had been raised at clinical governance regarding the safety of our inpatient ward rounds with particular reference to: documentation of clinical observations and National Early Warning Score (NEWS), compliance with Trust guidance for venous thromboembolism (VTE) risk assessment, antibiotic stewardship, palliative care and treatment escalation plans (TEP). This quality improvement project was conceived to ensure these parameters were considered and documented during the ward round, thereby improving patient care and safety...
2018: BMJ Open Quality
Takeshi Yoshida, Doreen Engelberts, Gail Otulakowski, Bhushan Katira, Martin Post, Niall D Ferguson, Laurent Brochard, Marcelo B P Amato, Brian P Kavanagh
BACKGROUND: In supine patients with acute respiratory distress syndrome, the lung typically partitions into regions of dorsal atelectasis and ventral aeration ("baby lung"). Positive airway pressure is often used to recruit atelectasis, but often overinflates ventral (already aerated) regions. A novel approach to selective recruitment of dorsal atelectasis is by "continuous negative abdominal pressure." METHODS: A randomized laboratory study was performed in anesthetized pigs...
April 27, 2018: Anesthesiology
Marta Pinto-Grau, Orla Hardiman, Niall Pender
Amyotrophic Lateral Sclerosis is a neurodegenerative disorder characterized primarily by motor network disruption. Extra-motor manifestations including executive functions, social cognition, and behavioral changes are now well recognized as important features of ALS, and are associated with frontotemporal and frontostriatal network disruption. However, the presence and characterization of language changes has received less attention. This systematic review characterizes the profile of reported language dysfunction in ALS...
April 28, 2018: Neuropsychology Review
James O'Donovan, Charles O'Donovan, Isla Kuhn, Sonia Ehrlich Sachs, Niall Winters
OBJECTIVES: Understanding the current landscape of ongoing training for community health workers (CHWs) in low-income and middle-income countries (LMICs) is important both for organisations responsible for their training, as well as researchers and policy makers. This scoping review explores this under-researched area by mapping the current delivery implementation and evaluation of ongoing training provision for CHWs in LMICs. DESIGN: Systematic scoping review. DATA SOURCES: MEDLINE, Embase, AMED, Global Health, Web of Science, Scopus, ASSIA, LILACS, BEI and ERIC...
April 28, 2018: BMJ Open
Cecile Sunahara, P Zelkowitz, Niall Bolger, Gentiana Sadikaj, Simcha Samuel, Ian Gold, Barbara Hayton, Nancy Feeley, C Sue Carter, Jennifer A Bartz
It is well-known that the neuropeptide oxytocin plays a critical role regulating the formation of adult-adult pairbonds in non-human animals, and recent work suggests oxytocin may similarly play an important role in romantic bonding in humans. Specifically, endogenous oxytocin is predictive of a host of relationship-enhancing behaviors, relationship quality, and even relationship survival amongst newly dating couples. This work suggests that oxytocin can buffer romantic relationships, possibly during especially difficult transition periods...
April 26, 2018: International Journal of Psychophysiology
David Ferland-McCollough, Davide Masseli, Gaia Spinetti, Maria Sambataro, Niall Sullivan, Ashley Blom, Paolo Madeddu
Fat accumulates in bone marrow (BM) of diabetic patients. Here, we investigated the mechanisms and consequences of this phenomenon. BM-mesenchymal stromal cells (BM-MSCs) from type-2 diabetic (T2D) patients constitutively express adipogenic markers and robustly differentiate into adipocytes (ADs) upon in-vitro induction as compared with BM-MSCs from non-diabetic subjects. Moreover, T2D BM adipocytes paracrinally stimulate a transcriptional adipogenic program in BM-MSCs. Antagonism of monocyte chemoattractant protein (MCP-1), a chemokine pivotally expressed in T2D BM-ADs, prevented the TD2 BM-AD secretome from converting BM-MSCs into ADs...
April 27, 2018: Diabetes
Marianna Spatola, Lidia Sabater, Jesús Planagumà, Eugenia Martínez-Hernandez, Thaís Armangué, Harald Prüss, Takahiro Iizuka, Ruben L Caparó Oblitas, Jean-Christophe Antoine, Richard Li, Nicholas Heaney, Niall Tubridy, Elvira Munteis Olivas, Myrna R Rosenfeld, Francesc Graus, Josep Dalmau
OBJECTIVE: To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters. METHODS: Clinical information was retrospectively obtained from referring physicians. Antibodies to mGluR5 and IgG subclasses were determined with brain immunohistochemistry and cell-based assays. The effects of the antibodies were examined on rat hippocampal neurons with reported techniques...
April 27, 2018: Neurology
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