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https://www.readbyqxmd.com/read/29155330/expression-pattern-and-functional-analysis-of-r-spondin1-in-tongue-sole-cynoglossus-semilaevis
#1
Jinxiang Liu, Tiantian Liu, Jingjing Niu, Xiaolong Wu, Jieming Zhai, Quanqi Zhang, Jie Qi
R-spondin 1 (Rspo1) is a potential female-determining gene in mammals that could regulate the Wnt/β-catenin signaling pathway. The deletion of Rspo1 causes sex reversal in females. To investigate sexual determination and differentiation, we cloned and analyzed the Rspo1 gene in Cynoglossus semilaevis. Phylogenetic and gene structure analyses revealed that Rspo1 gene exhibited high sequence conservation and contained an N-terminal signal peptide, two furin-like cysteine-rich domains (FU1 and FU2), a thrombospondin type 1 repeat, and a C-terminal region enriched with basic charged amino acids...
November 16, 2017: Gene
https://www.readbyqxmd.com/read/29155192/external-genital-development-urethra-formation-and-hypospadias-induction-in-guinea-pig-a-double-zipper-model-for-human-urethral-development
#2
Shanshan Wang, Mingxin Shi, Dongqing Zhu, Ranjiv Mathews, Zhengui Zheng
OBJECTIVES: To determine whether the guinea pig phallus would be an appropriate model of human penile development, we characterized the embryology and sexual differentiation of guinea pig external genitalia and attend to induce hypospadias in males and tubular urethra formation in females pharmacologically. MATERIALS AND METHODS: The external genitalia of guinea pig were collected from genital swelling initiation to newborn stages and Scanning Electronic Microscopy and histology were performed to visualize the morphology and structure...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29155091/dynamic-molecular-events-associated-to-plasmodium-berghei-gametogenesis-through-proteomic-approach
#3
Carlos H S Garcia, Delphine Depoix, Rayner M L Queiroz, Jaques M F Souza, Wagner Fontes, Marcelo V de Sousa, Marlon D M Santos, Paulo C Carvalho, Philippe Grellier, Sébastien Charneau
Plasmodium mature sexual cycle occurs in the vector mosquitoes and ensures the transmission to a new host. Gametogenesis takes place within minutes in the vector midgut. Gametocytes have to complete a deep nuclear reorganization, quick differentiation, and in the case of male gametocytes, intracytoplasmic flagellum assembly that results in free-swimming microgametes required for macrogamete fertilization. In efforts to improve our knowledge of molecular mechanisms involved in gamete morphogenesis, we carried out a nanoLC/MSMS based quantitative proteomic analysis throughout the xanthurenic acid-induced gametogenesis of the rodent parasite P...
November 15, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29154708/urethral-diverticulum-and-urolithiasis-in-a-female-guinea-pig-cavia-porcellus
#4
Lily A B Parkinson, Jennifer C Hausmann, Robert J Hardie, Megan A Mickelson, Kurt K Sladky
CASE DESCRIPTION A 5-year-old sexually intact female guinea pig was evaluated because of mild dysuria and a subcutaneous mass located cranioventral to the urogenital openings. CLINICAL FINDINGS Non-contrast-enhanced CT and surgical exploration of the distal aspect of the urethra revealed a urethral diverticulum with an intraluminal urolith. Analysis revealed that the urolith was composed of calcium carbonate and struvite. TREATMENT AND OUTCOME The urolith was surgically removed and ablation of the urethral diverticulum was attempted...
December 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29154643/gender-nonconformity-of-identical-twins-with-discordant-sexual-orientations-evidence-from-childhood-photographs
#5
Tuesday M Watts, Luke Holmes, Jamie Raines, Sheina Orbell, Gerulf Rieger
Childhood gender nonconformity (femininity in males, masculinity in females) predicts a nonstraight (gay, lesbian, or bisexual) sexual orientation in adulthood. In previous work, nonstraight twins reported more childhood gender nonconformity than their genetically identical, but straight, cotwins. However, self-reports could be biased. We therefore assessed gender nonconformity via ratings of photographs from childhood and adulthood. These ratings came from independent observers naïve to study hypotheses. Identical twins with discordant sexual orientations (24 male pairs, 32 female pairs) visibly differed in their gender nonconformity from mid-childhood, with higher levels of gender nonconformity observed in the nonstraight twins...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29153725/differentiating-among-attempted-completed-and-multiple-nonfatal-strangulation-in-women-experiencing-intimate-partner-violence
#6
Jill Theresa Messing, Michelle Patch, Janet Sullivan Wilson, Gabor D Kelen, Jacquelyn Campbell
PURPOSE: Because identification of intimate partner violence (IPV) in health care settings is low and strangulation increases lethality risk among women experiencing IPV, we examined the prevalence and correlates of nonfatal strangulation among 1,008 women survivors of IPV. METHODS: Trained researchers conducted semistructured interviews with women survivors of IPV referred by police. Multinomial logistic regression examined differential correlates of attempted, completed, and multiple strangulation...
November 16, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29153010/family-experiences-and-sexual-victimization-histories-a-comparative-analysis-between-youth-sexual-and-nonsexual-offenders
#7
Jamie Yoder, Rebecca Dillard, George S Leibowitz
Youth who commit sexual offenses often have sexual victimization histories that occur in the family context. These victimization experiences can be exacerbated by other risks present in the family environment. This research study uses MANOVAs to explore how family environments including substance use, mental health, physical and emotional victimization experiences, attachment, and parenting styles differentiate subgroups of youth offenders including youth sexual offenders with ( n = 179) and without ( n = 176) sexual victimization histories, and nonsexual offenders without sexual victimization histories ( n = 150)...
November 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29152868/trends-in-parental-monitoring-and-knowledge-over-time-between-sexual-minority-and-heterosexual-girls
#8
Gerald T Montano, Heather L McCauley, Elizabeth Miller, Deena J Chisolm, Michael P Marshal
This study assessed whether trajectories of parental monitoring components were different for sexual minority girls (SMGs) compared to heterosexual girls. We recruited 14-19-year-old girls from two adolescent medicine clinics. We estimated growth curve models to compare how components of parental monitoring-adolescent disclosure, parental solicitation, and parental knowledge-changed over 2 years for SMGs and heterosexual girls. SMGs and heterosexual girls had similar trajectory slopes and quadratic forms of adolescent disclosure, but SMGs had consistently lower adolescent disclosure scores...
December 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29152811/a-latent-class-analysis-of-online-sexual-experiences-and-offline-sexual-behaviors-among-female-adolescents
#9
Megan K Maas, Bethany C Bray, Jennie G Noll
This study used latent class analysis to identify patterns (i.e., classes) across a broad range of online sexual experiences among female adolescents (n = 312) and to explore offline sexual behavior and substance use correlates of as well as maltreatment differences in class membership. The following four classes were identified: Online Abstinent, Online Inclusive, Attractors, and Seekers. Maltreated female adolescents were more likely to be members of the Online Inclusive class and less likely to be members of the Online Abstinent class than nonmaltreated female adolescents...
November 20, 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29150546/differential-regulation-of-two-tiered-plant-immunity-and-sexual-reproduction-by-anxur-receptor-like-kinases
#10
Hyunggon Mang, Baomin Feng, Zhangjian Hu, Aurelien Boisson-Dernier, Christina Franck, Xiangzong Meng, Yanyan Huang, Jinggeng Zhou, Guangyuan Xu, Taotao Wang, Libo Shan, Ping He
Plants have evolved two tiers of immune receptors to detect infections: cell surface-resident pattern recognition receptors (PRRs) that sense microbial signatures and intracellular nucleotide-binding domain leucine-rich repeat (NLR) proteins that recognize pathogen effectors. How PRRs and NLRs interconnect and activate the specific and overlapping plant immune responses remains elusive. A genetic screen for components controlling plant immunity identified ANXUR1 (ANX1), a malectin-like domain-containing receptor-like kinase, together with its homolog ANX2, as important negative regulators of both PRR- and NLR-mediated immunity in Arabidopsis thaliana...
November 17, 2017: Plant Cell
https://www.readbyqxmd.com/read/29149326/virtually-in-the-heat-of-the-moment-insula-activation-in-safe-sex-negotiation-among-risky-men
#11
Benjamin J Smith, Feng Xue, Vita Droutman, Emily Barkley-Levenson, A James Melrose, Lynn C Miller, John R Monterosso, Antoine Bechara, Paul Robert Appleby, John L Christensen, Carlos G Godoy, Stephen J Read
HIV is most prevalent among men who have sex with men (MSM), and although most MSM use condoms consistently during casual sex, some take risks. To better understand the psychology of those risky decisions, we examined neural correlates of playing a virtual sexual "hook up" game in an fMRI scanner in MSM who had, in the past 90 days, been sexually risky (N = 76) or safe (N = 31). We found that during potentially risky sexual choices, previously risky MSM had more right insula activity than previously safe MSM...
November 15, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29144988/di-2-ethylhexyl-phthalate-enhances-melanoma-tumor-growth-via-differential-effect-on-m1-and-m2-polarized-macrophages-in-mouse-model
#12
Jae-Wook Lee, Sojin Park, Hae-Kyoung Han, Myung Chan Gye, Eun-Yi Moon
Phthalates are widely used as plasticizers that influence sexual and reproductive development. Here, we investigated whether di-(2-ethylhexyl) phthalate (DEHP) affects macrophage polarization that are associated with tumor initiation and progression. No changes were observed in LPS- or ConA-stimulated in vitro spleen B or T cell proliferation for 48 h, respectively. In contrast, macrophage functions were inhibited in response to DEHP for 12 h as judged by LPS-induced H2O2 and NO production and zymosan A-mediated phagocytosis...
November 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29140871/hiv-prevalence-and-associated-risk-factors-among-men-who-have-sex-with-men-in-dar-es-salaam-tanzania
#13
Elia John Mmbaga, Kåre Moen, Germana Henry Leyna, Rose Mpembeni, Melkizedeck Thomas Leshabari
INTRODUCTION: Limited studies and differential risk behaviours among men who have sex with men(MSM) in Africa calls for population specific studies. We present results from the largest integrated bio-behavioural survey among MSM in Africa to inform programming. METHODS: This was a cross-sectional study utilizing respondent driven sampling to recruit MSM aged 18 and above. Data on socio-demographic characteristics and HIV-related risks were collected and all participants were tested for HIV, Herpes Simplex Virus Type-2 (HSV-2), Hepatitis-B Virus (HBV) and Syphilis...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29140759/adult-profiles-of-child-sexual-abuse-survivors-attachment-insecurity-sexual-compulsivity-and-sexual-avoidance
#14
Chloe Labadie, Natacha Godbout, Marie-Pier Vaillancourt-Morel, Stéphane Sabourin
The present study examined the possibility of different groups of CSA survivors based on their different patterns of attachment and sexual problems. A sample of 324 CSA survivors and 484 participants who did not report any child maltreatment experiences completed online questionnaires. A cluster analysis on attachment and sexual outcomes revealed that CSA survivors formed two distinct profiles. The first profile included CSA survivors with elevated attachment anxiety and low to moderate scores on attachment avoidance, sexual compulsion, and sexual avoidance...
November 15, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29139126/understanding-the-association-between-discrimination-and-depression-among-sexual-minority-people-of-color-evidence-for-diminishing-returns-of-socioeconomic-advantage
#15
Megan Sutter, Paul B Perrin, Michael A Trujillo
OBJECTIVE: To examine the differential association of heterosexism and racism on depression as moderated by socioeconomic status (SES) among sexual minority people of color. METHOD: A cross-sectional sample of sexual minority people of color (n = 170) was surveyed on their experiences of heterosexism, racism, depression, and SES in a national online study based in the United States. RESULTS: Bivariately, SES was inversely associated with depression, racism, and heterosexism...
November 15, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29132074/robust-symptom-networks-in-recurrent-major-depression-across-different-levels-of-genetic-and-environmental-risk
#16
H M van Loo, C D Van Borkulo, R E Peterson, E I Fried, S H Aggen, D Borsboom, K S Kendler
BACKGROUND: Genetic risk and environmental adversity-both important risk factors for major depression (MD)-are thought to differentially impact on depressive symptom types and associations. Does heterogeneity in these risk factors result in different depressive symptom networks in patients with MD? METHODS: A clinical sample of 5784 Han Chinese women with recurrent MD were interviewed about their depressive symptoms during their lifetime worst episode of MD. The cases were classified into subgroups based on their genetic risk for MD (family history, polygenic risk score, early age at onset) and severe adversity (childhood sexual abuse, stressful life events)...
October 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29131362/sex-discordance-identification-following-non-invasive-prenatal-testing
#17
Ebony J Richardson, Fergus P Scott, Andrew C McLennan
OBJECTIVE: To characterize genotype-phenotype discordance identified in the routine clinical setting, and explore the associated diagnostic and counseling challenges. METHOD: Cases were derived from a cohort of pregnant women who attended a multi-site specialist prenatal screening and ultrasound service for non-invasive prenatal testing by cell-free DNA analysis and mid-trimester fetal morphology assessment. RESULTS: Seven cases of genotype-phenotype discordance were identified from a cohort of 12,919 women between June 2013 - March 2017 (incidence 1/1845 pregnancies)...
November 13, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29129619/transcriptional-profiling-validates-involvement-of-extracellular-matrix-and-proteinases-genes-in-mouse-gonad-development
#18
Rafal P Piprek, Michal Kolasa, Dagmara Podkowa, Malgorzata Kloc, Jacek Z Kubiak
Extracellular matrix (ECM) plays an important scaffolding role in the establishment of organs structure during development. A great number of ECM components and enzymes (proteinases) regulating formation/degradation of ECM during organ remodeling have been identified. In order to study the role of ECM in the mouse gonad development, especially during sexual differentiation of the gonads when the structure of the testis and ovary becomes established, we performed a global analysis of transcriptome in three main cell types of developing gonad (supporting, interstitial/stromal and germ cells) using transgenic mice, cell sorting and microarray...
November 9, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/29129376/lysophosphatidylcholine-regulates-sexual-stage-differentiation-in-the-human-malaria-parasite-plasmodium-falciparum
#19
Nicolas M B Brancucci, Joseph P Gerdt, ChengQi Wang, Mariana De Niz, Nisha Philip, Swamy R Adapa, Min Zhang, Eva Hitz, Igor Niederwieser, Sylwia D Boltryk, Marie-Claude Laffitte, Martha A Clark, Christof Grüring, Deepali Ravel, Alexandra Blancke Soares, Allison Demas, Selina Bopp, Belén Rubio-Ruiz, Ana Conejo-Garcia, Dyann F Wirth, Edyta Gendaszewska-Darmach, Manoj T Duraisingh, John H Adams, Till S Voss, Andrew P Waters, Rays H Y Jiang, Jon Clardy, Matthias Marti
Transmission represents a population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes, are infective to the mosquito vector. Gametocyte production rates vary depending on environmental conditions, but external stimuli remain obscure. Here, we show that the host-derived lipid lysophosphatidylcholine (LysoPC) controls P. falciparum cell fate by repressing parasite sexual differentiation...
November 2, 2017: Cell
https://www.readbyqxmd.com/read/29128984/taxonomic-resolution-and-functional-traits-in-the-analysis-of-tropical-oribatid-mite-assemblages
#20
Maria A Minor, Sergey G Ermilov, Alexei V Tiunov
We analysed species-level datasets representing Oribatida assemblages along a gradient of old-growth primary tropical forests, secondary forests, and plantation forests in Dong Nai Biosphere Reserve, Vietnam. We identified patterns in abundance, species richness and species assemblages of Oribatida, then applied taxonomic sufficiency approach to the datasets. Using three levels of higher-taxon aggregation, we evaluated whether aggregated datasets are useful in identifying ecological patterns, in comparison to species-level data...
November 11, 2017: Experimental & Applied Acarology
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