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https://www.readbyqxmd.com/read/29031245/decrease-in-cavity-size-and-oligodendrocyte-cell-death-using-neurosphere-derived-oligodendrocyte-like-cells-in-spinal-cord-contusion-model
#1
Hojjat Allah Abbaszadeh, Taki Tiraihi, Yousef Sadeghi, Ali Reza Delshad, Majid Sadeghizadeh, Taher Taheri, Ali Noori-Zadeh
Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes is progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells (OLCs) into the lesion area is one of the approaches to counterbalance this condition. Methods: Bone marrow stromal cells were transdifferentiated into neurospheres and then into neural stem cells and later were differentiated into OLCs using triiodothyronine and transplanted into the spinal cord contusion rats...
October 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29031235/homeobox-genes-and-tooth-development-understanding-the-biological-pathways-and-applications-in-regenerative-dental-science
#2
REVIEW
Anand Ramanathan, Thekkeparambil Chandrabose Srijaya, Prema Sukumaran, Rosnah Binti Zain, Noor Hayaty Abu Kasim
OBJECTIVES: Homeobox genes are a group of conserved class of transcription factors that function as key regulators during the embryonic developmental processes. They act as master regulator for developmental genes, which involves coordinated actions of various auto and cross-regulatory mechanisms. In this review, we summarize the expression pattern of homeobox genes in relation to the tooth development and various signaling pathways or molecules contributing to the specific actions of these genes in the regulation of odontogenesis...
October 4, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29031226/ectopic-vascularized-bone-formation-by-human-mesenchymal-stem-cell-microtissues-in-a-biocomposite-scaffold
#3
Rajan Narayan, Tarun Agarwal, Debasish Mishra, Somnath Maji, Sujata Mohanty, Asok Mukhopadhyay, Tapas Kumar Maiti
Three-dimensional multicellular human bone marrow mesenchymal stem cells (hBM-MSCs) are showing a great promise in the repair of bone tissue due to its osteogenic differentiation potential, mimicking in vivo microenvironment and immunomodulatory property. In the present study, the potential of hBM-MSC microtissues (MTs) in combination with a biocomposite material to form vascularized bone-like tissue at an ectopic site in an immunocompromised mouse was evaluated. The scaffold was fabricated using gelatin, carboxymethyl cellulose, polyvinyl alcohol and nano-hydroxyapatite (GCnHP) by the freeze-drying method...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031061/crassiflorone-derivatives-that-inhibit-trypanosoma-brucei-glyceraldehyde-3-phosphate-dehydrogenase-tbgapdh-and-trypanosoma-cruzi-trypanothione-reductase-tctr-and-display-trypanocidal-activity
#4
Elisa Uliassi, Giulia Fiorani, R Luise Krauth-Siegel, Christian Bergamini, Romana Fato, Giulia Bianchini, J Carlos Menéndez, Maria Teresa Molina, Eulogio López-Montero, Federico Falchi, Andrea Cavalli, Sheraz Gul, Maria Kuzikov, Bernhard Ellinger, Gesa Witt, Carolina B Moraes, Lucio H Freitas-Junior, Chiara Borsari, Maria Paola Costi, Maria Laura Bolognesi
Crassiflorone is a natural product with anti-mycobacterial and anti-gonorrhoeal properties, isolated from the stem bark of the African ebony tree Diospyros crassiflora. We noticed that its pentacyclic core possesses structural resemblance to the quinone-coumarin hybrid 3, which we reported to exhibit a dual-targeted inhibitory profile towards Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR). Following this basic idea, we synthesized a small library of crassiflorone derivatives 15-23 and investigated their potential as anti-trypanosomatid agents...
October 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29029297/cytomegalovirus-specific-t-cell-transfer-for-refractory-cytomegalovirus-infection-after-haploidentical-stem-cell-transplantation-the-quantitative-and-qualitative-immune-recovery-for-cytomegalovirus
#5
Xu-Ying Pei, Xiang-Yu Zhao, Ying-Jun Chang, Jing Liu, Lan-Ping Xu, Yu Wang, Xiao-Hui Zhang, Wei Han, Yu-Hong Chen, Xiao-Jun Huang
Background: The efficiency and mechanisms of adoptive transfer of cytomegalovirus (CMV)specific T cells for refractory CMV infection after haploidentical stem cell transplantation (haplo-SCT) remain largely unknown. Methods: Thirty-two patients with refractory CMV infection who accepted treatment with adoptive CMV-specific T-cell infusion following haplo-SCT were prospectively enrolled. Another 32 patients with nonrefractory CMV infection after haplo-SCT were selected as control subjects...
September 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029025/insulin-deficient-mouse-%C3%AE-cells-do-not-fully-mature-but-can-be-remedied-through-insulin-replacement-by-islet-transplantation
#6
Adam Ramzy, Majid Mojibian, Timothy J Kieffer
Insulin receptor insufficiency in β-cells leads to impaired insulin secretion and reduced β-cell hyperplasia in response to hyperglycemia. Selective insulin receptor deficiency in β-cells in later embryological development may lead to compensatory β-cell hyperplasia. Though these findings suggest insulin signaling on the β-cell is important for β-cell function, they are confounded by loss of signaling by the IGFs through the insulin receptor. To determine if insulin itself is necessary for β-cell development and maturation, we performed a characterization of pancreatic islets in mice with deletions of both non-allelic insulin genes (Ins1-/-Ins2-/-)...
September 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028873/mirna-in-tumour-metabolism-and-why-could-it-be-the-preferred-pathway-for-energy-reprograming
#7
Aliaa A Alamoudi, Amina Alnoury, Hoda Gad
The current literature on the role of microRNA (miRNA) in tumour metabolism is growing, and a number of studies regularly confirm the impact miRNA can have in energy reprograming in tumours. However, there remains to be a lack of understanding of the larger perspective of the role of miRNA in the metabolism story. In the first part of this review, we provide a comprehensive and up-to-date description of the extensive role of miRNAs in tumour metabolism including glucose, lipid and amino acid metabolism. However, in the second part, we aim to provide a description of the multidimensional role miRNA can be playing in tumour metabolism...
September 23, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29028868/symplasmic-and-apoplasmic-transport-inside-feather-moss-stems-of-pleurozium-schreberi-and-hylocomium-splendens
#8
K Sokolowska, M Turzanska, M-C Nilsson
Background and Aims: The ubiquitous feather mosses Pleurozium schreberi and Hylocomium splendens form a thick, continuous boundary layer between the soil and the atmosphere, and play important roles in hydrology and nutrient cycling in tundra and boreal ecosystems. The water fluxes among these mosses and environmental factors controlling them are poorly understood. The aim of this study was to investigate whether feather mosses are capable of internal transport and to provide a better understanding of species-specific morphological traits underlying this function...
September 28, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29028842/in-vitro-investigation-of-head-and-neck-cancer-stem-cell-proportions-and-their-changes-following-x-ray-irradiation-as-a-function-of-hpv-status
#9
Paul Reid, Puthenparampil Wilson, Yanrui Li, Loredana G Marcu, Alexander H Staudacher, Michael P Brown, Eva Bezak
INTRODUCTION: Some head and neck squamous cell carcinomas (HNSCC) have a distinct aetiology, which depends on the presence of oncogenic human papilloma virus (HPV). Also, HNSCC contains cancer stem cells (CSCs) that have greater radioresistance and capacity to change replication dynamics in response to irradiation compared to non-clonogenic cells. Since there is limited data on CSCs in HNSCC as a function of HPV status, better understanding of their radiobiology may enable improved treatment outcome...
2017: PloS One
https://www.readbyqxmd.com/read/29028833/merkel-cell-polyomavirus-recruits-mycl-to-the-ep400-complex-to-promote-oncogenesis
#10
Jingwei Cheng, Donglim Esther Park, Christian Berrios, Elizabeth A White, Reety Arora, Rosa Yoon, Timothy Branigan, Tengfei Xiao, Thomas Westerling, Alexander Federation, Rhamy Zeid, Benjamin Strober, Selene K Swanson, Laurence Florens, James E Bradner, Myles Brown, Peter M Howley, Megha Padi, Michael P Washburn, James A DeCaprio
Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST). While LT binds RB and inactivates its tumor suppressor function, it is less clear how ST contributes to MCC tumorigenesis. Here we show that ST binds specifically to the MYC homolog MYCL (L-MYC) and recruits it to the 15-component EP400 histone acetyltransferase and chromatin remodeling complex. We performed a large-scale immunoprecipitation for ST and identified co-precipitating proteins by mass spectrometry...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29028786/reducer-extracorporeal-shockwave-therapy-or-stem-cells-in-refractory-angina-a-retrospective-study
#11
Massimo Slavich, Francesco Giannini, Cosmo Godino, Giuseppe Pizzetti, Mario Gramegna, Gabriele Fragasso, Alberto Margonato
No abstract text is available yet for this article.
October 11, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29028628/role-of-pdgf-bb-in-proliferation-differentiation-and-maintaining-stem-cell-properties-of-pdl-cells-in-vitro
#12
Zornitsa Mihaylova, Rozaliya Tsikandelova, Pavel Sanimirov, Natalia Gateva, Vanyo Mitev, Nikolay Ishkitiev
OBJECTIVE: Platelet-derived growth factor-BB (PDGF-BB) is one of the most abundant growth factors in platelet derived products and has been shown to stimulate regeneration after tissue injury. There is a population of mesenchymal stem cells (MSC) in human periodontal ligament (PDL) which can contribute to tissue regeneration under appropriate conditions. DESIGN: PDL cells were isolated and characterized using stem cell and differentiation markers via immunofluorescence and flow cytometry and then cultured in vitro and treated with different concentrations of PDGF-BB...
September 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29028589/tanshinoneiia-enhances-the-chemosensitivity-of-breast-cancer-cells-to-doxorubicin-through-down-regulating-the-expression-of-mdr-related-abc-transporters
#13
Kun Li, Hong Lai
As the first-line drug for breast cancer chemotherapy, doxorubicin (Dox) has strong cardiotoxicity. Meanwhile, prolonged Dox treatment of patients with breast cancer may result in resistance of breast cancer cells to Dox and an increased number of Dox-resistant breast cancer stem cells (BCSCs), thereby easily leading to breast cancer relapse. TanshinoneIIA (Tan IIA) has anti-tumor activity in addition to its cardiovascular protective effect. By preparing Dox resistant human breast cancer MCF-7 cells, here, we wanted to assess a new use of Tan IIA in enhancing the chemosensitivity of breast cancer cells to Dox and investigated its possible mechanisms...
October 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29028349/proteomic-profiling-of-%C3%AE-hcg-induced-spheres-in-brca1-defective-triple-negative-breast-cancer-cells
#14
Satheesh Kumar Sengodan, Arathi Rajan, Sreelatha Krishnakumar Hemalatha, Revathy Nadhan, Abdul Jaleel, Priya Srinivas
Previously we identified that β-hCG is expressed by BRCA1 mutated but not wild type breast cancers in-vitro/in-vivo and exhibit a novel event in β-hCG over expressing BRCA1 mutated HCC1937cells where the cells were able to form spheres in adherent cell culture plates even in the absence of any growth factors. These spheres express stem cell and EMT markers. In the present study we carried out the total proteomic profiling of these HCC1937 β spheres obtained from BRCA1 defective β-hCG expressing stable breast cancer cells to analyze the cell signaling pathways that are active in these cells...
October 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29028335/metallo-supramolecular-complexes-enantioselectively-eradicate-cancer-stem-cells-in-vivo
#15
Hongshuang Qin, Chuanqi Zhao, Yuhuan Sun, Jinsong Ren, Xiaogang Qu
Cancer stem cells (CSCs) are responsible for drug resistance, metastasis and recurrence of cancers. However, there is still no clinically approved drug that can effectively eradicate CSCs. Thus, it is crucial and important to develop specific CSC-targeting agents. Chiral molecular recognition of DNA plays an important role in rational drug design. Among them, poly-morphic telomeric G-quadruplex DNA has received much attention due to its significant roles in telomerase activity and chromosome stability. Herein, we find that one enantiomer of zinc-finger-like chiral metallohelices, [Ni2L3]4+-P, a telomeric G-quadruplex-targeting ligand, can preferentially reduce cell growth in breast CSCs compared to the bulk cancer cells...
October 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29028326/ratiometric-ph-imaging-with-a-co-ii-2-mri-probe-via-cest-effects-of-opposing-ph-dependences
#16
Agnes E Thorarinsdottir, Kang Du, James H P Collins, T David Harris
We report a Co2-based magnetic resonance (MR) probe that enables the ratiometric quantitation and imaging of pH through chemical exchange saturation transfer (CEST). This approach is illustrated in a series of air- and water-stable Co(II)2 complexes featuring CEST-active tetra(carboxamide) and/or hydroxyl-substituted bisphosphonate ligands. For the complex bearing both ligand types, variable-pH CEST and NMR analyses reveal highly-shifted carboxamide and hydroxyl peaks with intensities that increase and decrease with increasing pH, respectively...
October 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29028313/anomalous-corrosion-of-bulk-transition-metal-diselenides-leading-to-stable-monolayers
#17
Yu-Ting Huang, Akhil Dodda, Daniel S Schulman, Amritanand Sebastian, Fu Zhang, Drew Buzzell, Mauricio Terrones, Shien-Ping Feng, Saptarshi Das
In this paper we provide insight into an anomalous corrosion process, referred to as electro-ablation (EA), which converts multi-layer flakes of transition metal diselenides like MoSe2 into their corresponding monolayers when micromechanically exfoliated on a conductive electrode and subsequently subjected to a high anodic potential inside a conventional electrochemical cell. Photoluminescence intensity map and scanning transmission electron microscopy (STEM) images confirmed the single crystalline nature and 2H-hexagonal lattice structure of the remnant monolayer MoSe2 flakes, indicating the superior corrosion stability of the monolayers compared to the bulk counterpart...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29028259/stem-cell-transplantation-for-frailty
#18
David G Le Couteur, Rozalyn M Anderson, Anne B Newman, Rafael de Cabo
No abstract text is available yet for this article.
October 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29028220/pediatric-brain-repair-from-endogenous-neural-stem-cells-of-the-subventricular-zone
#19
REVIEW
Yusuke Niimi, Steven W Levison
There is great interest in the regenerative potential of the neural stem cells and progenitors that populate the germinal zones of the immature brain. Studies using animal models of pediatric brain injuries have provided a clearer understanding of the responses of these progenitors to injury. In this review we have compared and contrasted the responses of the endogenous neural stem cells and progenitors of the subventricular zone in animal models of neonatal cerebral hypoxia-ischemia, neonatal stroke, congenital cardiac disease and pediatric traumatic brain injury...
October 13, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29028117/comparison-of-weight-based-dosing-strategies-for-intravenous-immunoglobulin-in-patients-with-hematologic-malignancies
#20
Sarah E Stump, Allison J Schepers, Alexis R Jones, Maurice D Alexander, Jessica J Auten
STUDY OBJECTIVE: Intravenous immunoglobulin (IVIG) is a weight-based therapy used to treat and prevent infections in patients with hematologic malignancies. Traditionally, IVIG doses have been calculated using actual body weight (ABW). However, limited pharmacokinetic (PK) data suggest dosing strategies using ideal body weight (IBW) or adjusted body weight (adjBW) may be appropriate given the small volume of distribution of IVIG. The objective of this study was to compare the effectiveness of using a precision-dosing strategy (IBW or adjBW) to a traditional-dosing strategy (ABW) for IVIG in patients with hematologic malignancies or those undergoing hematopoietic stem cell transplant, as well as to perform an IVIG drug use analysis...
October 13, 2017: Pharmacotherapy
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