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https://www.readbyqxmd.com/read/29342402/cutaneous-cryptococcosis-mimicking-leishmaniasis
#1
Alexandre Moretti de Lima, Milena Marchini Rodrigues, Carmelia Matos Santiago Reis
No abstract text is available yet for this article.
January 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29340474/cryptococcosis-in-a-transplanted-kidney-allograft
#2
Stanley de Almeida Araújo, André Barreto Pereira, Roberto Ferreira de Almeida Araújo
No abstract text is available yet for this article.
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29338706/miliary-tuberculosis-with-co-existing-pulmonary-cryptococcosis-in-non-hiv-patient-without-underlying-diseases-a-case-report
#3
Toyomitsu Sawai, Takumi Nakao, Satoru Koga, Shotaro Ide, Sumako Yoshioka, Nobuko Matsuo, Hiroshi Mukae
BACKGROUND: Tuberculosis and cryptococcosis co-infection usually occurs in immunosuppressed patients with impaired cell-mediated immunity. However, there are few reports about such co-infection in non-HIV patients without underlying diseases. Here, we report a case of miliary tuberculosis with co-existing pulmonary cryptococcosis in non-HIV patient without underlying diseases. CASE PRESENTATION: An 84-year-old Asian female presented to our hospital with complaints of a 1-week history of abdominal pain and appetite loss...
January 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29327953/multicentric-cryptococcosis-in-a-congo-african-grey-parrot-psittacus-erithacus-erithacus
#4
Raina S K Schunk, Nicholas E Sitinas, Katherine E Quesenberry, Jessica L Grodio
An approximately 10-year-old, female Congo African grey parrot ( Psittacus erithacus erithacus) developed progressive, unilateral exophthalmos and buphthalmos. Survey radiographs revealed a large, coelomic, soft tissue mass, which was confirmed on computed tomography scan. Aspirates of both the contents of the buphthalmic globe and coelomic mass were consistent with Cryptococcus species. Initial results were later confirmed with serum antigen latex agglutination and polymerase chain reaction testing, and the organism was then identified as Cryptococcus neoformans with DNA sequencing...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29320833/-analysis-of-9-cases-of-nodular-type-of-pulmonary-cryptococcosis-with-coexisting-lung-cancer-confirmed-by-pathological-examinations
#5
H Y Li, C Q Lan, H Weng, S X Chen, Q H Lin, J B Huang
Objective: To describe the characteristics of the nodular type of pulmonary cryptococcosis (PC) with coexisting lung cancer. Methods: A total of 9 cases of PC with coexisting lung cancer, admitted to Fuzhou Pulmonary Hospital of Fujian from 1st January 2009 to 31th December 2016, and confirmed by pathological examinations, were studied and the related literature were reviewed. Results: The patients consisted of 1 male and 8 females, with a mean age of (53±10) years (range, 38 to 68 years). Four patients (44...
November 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29319242/clinical-diversity-of-cns-cryptococcosis
#6
J M Koshy, S Mohan, D Deodhar, M John, A Oberoi, A Pannu
Background: Though cryptococcal meningitis (CM) is recognized as a disease of the immunocompromised, studies have implicated that it also affect immunocompetent patients. Methodology: This was a cross sectional study conducted in the Department of Medicine of a tertiary teaching institution in North India. All the patients diagnosed with CM on the basis of detection of cryptococcal antigen or the presence of capsulated budding yeast cells on India ink preparation, from April 2009 to March2015 were included in the study...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29319241/cryptococcosis-the-ubiquitous-yeast
#7
Amar R Pazare
No abstract text is available yet for this article.
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29317510/the-f-box-protein-fbp1-shapes-the-immunogenic-potential-of-cryptococcus-neoformans
#8
Jorge Masso-Silva, Vanessa Espinosa, Tong-Bao Liu, Yina Wang, Chaoyang Xue, Amariliz Rivera
Cryptococcus neoformans is the main etiologic agent of cryptococcal meningitis and causes a significant number of deadly infections per year. Although it is well appreciated that host immune responses are crucial for defense against cryptococcosis, our understanding of factors that control the development of effective immunity to this fungus remains incomplete. In previous studies, we identified the F-box protein Fbp1 as a novel determinant of C. neoformans virulence. In this study, we found that the hypovirulence of the fbp1Δ mutant is linked to the development of a robust host immune response...
January 9, 2018: MBio
https://www.readbyqxmd.com/read/29307928/spect-ct-with-radiolabeled-somatostatin-analogues-in-the-evaluation-of-systemic-granulomatous-infections
#9
Paulo Henrique Silva Monteiro, Thiago Ferreira de Souza, Maria Luiza Moretti, Mariangela Ribeiro Resende, Jair Mengatti, Mariana da Cunha Lopes de Lima, Allan Oliveira Santos, Celso Darío Ramos
Objective: To evaluate SPECT/CT with radiolabeled somatostatin analogues (RSAs) in systemic granulomatous infections in comparison with gallium-67 (67Ga) citrate scintigraphy. Materials and Methods: We studied 28 patients with active systemic granulomatous infections, including tuberculosis, paracoccidioidomycosis, pneumocystosis, cryptococcosis, aspergillosis, leishmaniasis, infectious vasculitis, and an unspecified opportunistic infection. Of the 28 patients, 23 had started specific treatment before the study outset...
November 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/29307925/magnetic-resonance-imaging-findings-in-central-nervous-system-cryptococcosis-comparison-between-immunocompetent-and-immunocompromised-patients
#10
Stenio Bruno Leal Duarte, Mariana Mari Oshima, João Vitor do Amaral Mesquita, Felipe Barjud Pereira do Nascimento, Paula Christina de Azevedo, Fabiano Reis
Objective: To assess the magnetic resonance imaging (MRI) patterns associated with central nervous system infection with Cryptococcus sp. in relation to patient immune status. Materials and Methods: This was a retrospective study of MRI data for 19 patients with neurocryptococcosis who underwent the examination between January 2000 and March 2014. The MRI characteristics examined included lesion topography, aspects of diffusion, T1-weighted images, T2-weighted images, and contrast enhancement patterns...
November 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/29299844/vacuolar-zinc-transporter-zrc1-is-required-for-detoxification-of-excess-intracellular-zinc-in-the-human-fungal-pathogen-cryptococcus-neoformans
#11
Minsu Cho, Guanggan Hu, Mélissa Caza, Linda C Horianopoulos, James W Kronstad, Won Hee Jung
Zinc is an important transition metal in all living organisms and is required for numerous biological processes. However, excess zinc can also be toxic to cells and cause cellular stress. In the model fungus Saccharomyces cerevisiae, a vacuolar zinc transporter, Zrc1, plays important roles in the storage and detoxification of excess intracellular zinc to protect the cell. In this study, we identified an ortholog of the S. cerevisiae ZRC1 gene in the human fungal pathogen Cryptococcus neoformans. Zrc1 was localized in the vacuolar membrane in C...
January 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29284182/cryptococcosis-and-cryptococcal-meningitis-new-predictors-and-clinical-outcomes-at-a-united-states-academic-medical-center
#12
Bahar H Kashef Hamadani, Carlos Franco-Paredes, Bruce McCollister, Leland Shapiro, David Beckham, Andrés F Henao-Martínez
Since the diagnosis of cryptococcosis is challenging in low prevalence settings, uncovering predictive factors can improve early diagnosis and timely treatment. The aim of the study was to relate clinical outcomes to predictive variables for the presence of cryptococcosis. A retrospective case-control study matching by collection date, age, and gender at a 1:2 ratio (55 cases and 112 controls) was performed in case patients diagnosed with Cryptococcus infection at the University of Colorado Hospital between 2000 and 2017 (n=167)...
December 28, 2017: Mycoses
https://www.readbyqxmd.com/read/29280227/neuroimaging-of-dilated-perivascular-spaces-from-benign-and-pathologic-causes-to-mimics
#13
REVIEW
Jeffrey D Rudie, Andreas M Rauschecker, Seyed A Nabavizadeh, Suyash Mohan
Perivascular spaces (PVSs), also known as Virchow-Robin spaces, are pial-lined, fluid-filled structures found in characteristic locations throughout the brain. They can become abnormally enlarged or dilated and in rare cases can cause hydrocephalus. Dilated PVSs can pose a diagnostic dilemma for radiologists because of their varied appearance, sometimes mimicking more serious entities such as cystic neoplasms, including dysembryoplastic neuroepithelial tumor and multinodular and vacuolating neuronal tumor, or cystic infections including toxoplasmosis and neurocysticercosis...
December 27, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29273275/modulatory-effect-of-voriconazole-on-the-production-of-proinflammatory-cytokines-in-experimental-cryptococcosis-in-mice-with-severe-combined-immunodeficiency
#14
E Gonçalves Silva, S Marilia de Souza Silva, C Rodrigues Paula, L da Silva Ruiz, A Latercia Tranches Dias
Cryptococcosis is a subacute or chronic disease. For many years, amphotericin B has been used in severe fungal infections. Voriconazole is a triazole with high bioavailability, a large distribution volume, and excellent penetration of the central nervous system (CNS). The objective of this study was to evaluate the production of pro-inflammatory cytokines in the lungs during an experimental infection caused by C. neoformans in murine model (SCID) that was treated with amphotericin B and voriconazole. After intravenous inoculation with 3...
December 19, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29237413/clinical-features-of-pulmonary-cryptococcosis-among-patients-with-different-levels-of-peripheral-blood-cd4-t-lymphocyte-counts
#15
Qian He, Yuan Ding, Wei Zhou, Hongxing Li, Ming Zhang, Yi Shi, Xin Su
BACKGROUND: The clinical manifestation of pulmonary cryptococcosis varies notably between immunocompromised and immunocompetent patients. To better understand pulmonary cryptococcosis, we compared the clinical features of pulmonary cryptococcosis patients with or without decreased peripheral blood CD4+ T cell counts. METHODS: We retrospectively reviewed the medical records of 80 patients with cryptococcosis who had been treated in Jingling Hospital from January 2011 to January 2016...
December 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29233901/immune-mediated-damage-completes-the-parabola-cryptococcus-neoformans-pathogenesis-can-reflect-the-outcome-of-a-weak-or-strong-immune-response
#16
Liise-Anne Pirofski, Arturo Casadevall
Cryptococcosis occurs most frequently in immunocompromised individuals. This has led to the prevailing view that this disease is the result of weak immune responses that cannot control the fungus. However, increasingly, clinical and experimental studies have revealed that the host immune response can contribute to cryptococcal pathogenesis, including the recent study of L. M. Neal et al. (mBio 8:e01415-17, 2017, https://doi.org/10.1128/mBio.01415-17) that reports that CD4+ T cells mediate tissue damage in experimental murine cryptococcosis...
December 12, 2017: MBio
https://www.readbyqxmd.com/read/29224242/dermoscopic-observations-in-disseminated-cryptococcosis-with-cutaneous-involvement
#17
M Sławińska, M Hlebowicz, E Iżycka-Świeszewska, M Sikorska, M Sokołowska-Wojdyło, T Smiatacz, R Nowicki, M Sobjanek
A 26-year-old female patient with a history of intravenous drug abuse, diagnosed with acquired immunodeficiency syndrome (AIDS) 6 months before. AIDS defining disease was Pneumocystis jiroveci pneumonia. The patient presented with severely decreased CD4 cell count of 7 cells/mm3 and relatively low HIV viral load of 281 copies/mL. Shortly after initiation of antiretroviral therapy (ART), was diagnosed with disseminated cryptococcosis with central nervous system and skin involvement. This article is protected by copyright...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29214970/comparative-typing-analyses-of-clinical-and-environmental-strains-of-the-cryptococcus-neoformans-cryptococcus-gattii-species-complex-from-ivory-coast
#18
Fulgence K Kassi, Virginie Bellet, Pascal Drakulovski, Donika Krasteva, Frédéric Roger, Bedia-Tanoh A Valérie, Touré Aboubakar, Adama Doumbia, Gisèle A Kouakou, Eric Delaporte, Jacques Reynes, William Yavo, Hervé I E Menan, Sebastien Bertout
PURPOSE: The aim of this study was to assess the biotope of the Cryptococcus neoformans/Cryptococcus gattii species complex from Ivory Coast, and clarify the possible epidemiological relationship between environmental and clinical strains. METHODOLOGY: Samples from Eucalyptus camaldulensis (n=136), Mangifera indica (n=13) and pigeon droppings (n=518) were collected from different sites close to the living environment of Ivorian HIV patients with cryptococcosis (n=10, 50 clinical strains)...
December 7, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29214004/prevalence-of-cryptococcal-antigen-positivity-among-hiv-infected-patient-with-cd4-cell-count-less-than-100-of-imam-khomeini-hospital-tehran-iran
#19
Mahboobeh Hajiabdolbaghi, Saeed Kalantari, Mahin Jamshidi-Makiani, Esfandiar Shojaei, Ladan Abbasian, Mehrnaz Rasoulinezhad, Katayoun Tayeri
Background and Objectives: Cryptococcal meningitis is one of the main opportunistic infections associated with human immunodeficiency virus (HIV) infection. Despite the present and increasingly availability of specific treatment for cryptococcosis, the mortality rate of this infection is still high, particularly in patients with advanced immunsupression and advanced cryptococcal diseases. Materials and Methods: This Prospective Cohort study was conducted at Imam Khomeini hospital in Tehran, Iran...
April 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29213074/galectin-3-impacts-cryptococcus-neoformans-infection-through-direct-antifungal-effects
#20
Fausto Almeida, Julie M Wolf, Thiago Aparecido da Silva, Carlos M DeLeon-Rodriguez, Caroline Patini Rezende, André Moreira Pessoni, Fabrício Freitas Fernandes, Rafael Silva-Rocha, Roberto Martinez, Marcio L Rodrigues, Maria Cristina Roque-Barreira, Arturo Casadevall
Cryptococcus neoformans is an encapsulated fungal pathogen that causes cryptococcosis, which is a major opportunistic infection in immunosuppressed individuals. Mammalian β-galactoside-binding protein Galectin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during microbial infections including some fungal diseases. Here we show that this protein plays a role also in C. neoformans infection. We find augmented Gal-3 serum levels in human and experimental infections, as well as in spleen, lung, and brain tissues of infected mice...
December 6, 2017: Nature Communications
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