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https://www.readbyqxmd.com/read/29055244/a-pilot-study-comparing-mechanical-properties-of-tissue-engineered-cartilages-and-various-endogenous-cartilages
#1
Andrew K Pappa, Sajjad Soleimani, Montserrat Caballero, Alexandra E Halevi, John A van Aalst
BACKGROUND: Mechanical properties of tissue-engineered cartilage and a variety of endogenous cartilage were measured. The main goal was to evaluate if the tissue-engineered cartilage have similar mechanical characteristics to be replaced with rib cartilage in microtia reconstruction. Such study lays the foundation for future human clinical trials for microtia reconstruction. METHOD: Atomic force microscopy and compression testing were used to measure the viscoelasticity of tissue-engineered cartilage (stem cell seeded on Poly lactic co-glycolytic acid nanofibers and Pellet) and endogenous cartilage: conchal bowl, microtic ears, preauricular remnants, and rib...
October 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29055138/effects-of-a-bone-graft-substitute-consisting-of-porous-gradient-ha-zro2-and-gelatin-chitosan-slow-release-hydrogel-containing-bmp-2-and-bmscs-on-lumbar-vertebral-defect-repair-in-rhesus-monkey
#2
Rong-Xue Shao, Ren-Fu Quan, Tuo Wang, Wei-Bin Du, Gao-Yong Jia, Dong Wang, Long-Bao Lv, Cai-Yin Xu, Xi-Cheng Wei, Jin-Fu Wang, Di-Sheng Yang
Dense biomaterial plays an important role in bone replacement. However, it fails to induce bone-cell migration into graft material. In the present study, a novel bone-graft substitute (BGS) consisting of porous gradient HA/ZrO2 composite (PGHC) and gelatin/chitosan slow-release hydrogel containing BMP-2 and BMSCs was designed and prepared to repair lumbar vertebral defects. The morphological characteristics of the BGS evaluated by scanning electron microscope showed that it had a three-dimensional network structure with uniformly distributed chitosan microspheres on the surfaces of the graft material and the interior of the pores...
October 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29054525/development-of-a-tannic-acid-cross-linking-process-for-obtaining-3d-porous-cell-laden-collagen-structure
#3
JiUn Lee, Miji Yeo, WonJin Kim, YoungWon Koo, Geun Hyung Kim
Cell-printing is an emerging technique that enables to build a customized structure using biomaterials and living cells for various biomedical applications. In many biomaterials, alginate has been widely used for rapid gelation, low cost, and relatively high processability. However, biocompatibilities enhancing cell adhesion and proliferation were limited, so that, to overcome this problem, an outstanding alternative, collagen, has been extensively investigated. Many factors remain to be proven for cell-printing applications, such as printability, physical sustainability after printing, and applicability of in vitro cell culture...
October 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29054313/imaging-biomaterial-tissue-interactions
#4
REVIEW
Yu Shrike Zhang, Junjie Yao
Modern biomedical imaging has revolutionized life science by providing anatomical, functional, and molecular information of biological species with high spatial resolution, deep penetration, enhanced temporal responsiveness, and improved chemical specificity. In recent years, these imaging techniques have been increasingly tailored for characterizing biomaterials and probing their interactions with biological tissues. This in turn has spurred substantial advances in engineering material properties to accommodate different imaging modalities that was previously unattainable...
October 17, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29054003/adhesion-force-sensing-and-activation-of-a-membrane-bound-sensor-to-activate-nisin-efflux-pumps-in-staphylococcus-aureus-under-mechanical-and-chemical-stresses
#5
Vera Carniello, Akshay K Harapanahalli, Henk J Busscher, Henny C van der Mei
Nisin-associated-sensitivity-response-regulator (NsaRS) in Staphylococcus aureus is important for its adhesion to surfaces and resistance against antibiotics, like nisin. NsaRS consists of an intra-membrane-located sensor NsaS and a cytoplasmatically-located response-regulator NsaR, which becomes activated upon receiving phosphate groups from the intra-membrane-located sensor. HYPOTHESIS: The intra-membrane location of the NsaS sensor leads us to hypothesize that the two-component NsaRS system not only senses "chemical" (nisin) but also "mechanical" (adhesion) stresses to modulate efflux of antibiotics from the cytoplasm...
October 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29052367/decellularized-caprine-liver-extracellular-matrix-as-a-2d-substrate-coating-and-3d-hydrogel-platform-for-vascularized-liver-tissue-engineering
#6
Tarun Agarwal, Rajan Narayan, Somnath Maji, Sudip Kumar Ghosh, Tapas Kumar Maiti
Development of a vascularized liver tissue construct is a need of an hour to circumvent the current demand of liver transplantation in healthcare sector. An appropriate matrix must support liver cell viability, functionality, and development of microvasculature. With this perspective, here, we report the use of decellularized Caprine liver ECM (CLECM) derived hydrogel for tissue engineering applications. First, CLECM was used as a substrate coating material for 2D hepatocyte culture. HepG2 cells cultured on CLECM coated surface showed higher albumin, urea, glycogen and GAGs synthesis in comparison to collagen coated surface (taken as control for the study)...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29052365/inferior-in-vivo-osteogenesis-and-superior-angiogeneis-of-human-adipose-tissue-compared-with-bone-marrow-derived-stromal-stem-cells-cultured-in-xeno-free-conditions
#7
Meadhbh A Brennan, Audrey Renaud, Fabien Guilloton, Miryam Mebarki, Valerie Trichet, Luc Sensebé, Frederic Deschaseaux, Nathalie Chevallier, Pierre Layrolle
The possibility of using adipose tissue-derived stromal cells (ATSC) as alternatives to bone marrow-derived stromal cells (BMSC) for bone repair has garnered interest due to the accessibility, high cell yield, and rapid in vitro expansion of ATSC. For clinical relevance, their bone forming potential in comparison to BMSC must be proven. Distinct differences between ATSC and BMSC have been observed in vitro and comparison of osteogenic potential in vivo is not clear to date. The aim of the current study was to compare the osteogenesis of human xenofree-expanded ATSC and BMSC in vitro and in an ectopic nude mouse model of bone formation...
October 19, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29052356/in-vitro-biocompatibility-bioactivity-and-photoluminescence-properties-of-eu-3-sr-2-dual-doped-nano-hydroxyapatite-for-biomedical-applications
#8
Lakshmanaperumal Sundarabharathi, Hemalatha Parangusan, Deepalekshmi Ponnamma, Mariam Al Ali Al-Maadeed, Mahendran Chinnaswamy
In the present investigation, we have successfully synthesized luminescent Eu(3+) -doped and Eu(3+) /Sr(2+) codoped hydroxyapatite (HA) nanoparticles through sol-gel assisted precipitation method with the aim of developing novel biomaterials containing osteoblast mineral (Sr(2+) ) and luminescence activator (Eu(3+) ). The structure, morphology, thermal stability, and luminescence properties of the resultant spherical nanoparticles (50-100 nm diameters) were studied. Moreover, the in-vitro bioactivity of Eu0...
October 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29052310/effect-of-functionalized-phema-micro-and-nano-particles-on-the-viscoelastic-properties-of-fibrin-agarose-biomaterials
#9
Giuseppe Scionti, Laura Rodriguez-Arco, Modesto T Lopez-Lopez, Antonio L Medina-Castillo, Ingrid Garzón, Miguel Alaminos, Manuel Toledano, Raquel Osorio
Two types of PHEMA-based particles, exhibiting either carboxyl or tertiary ammine functional groups, were incorporated to fibrin-agarose hydrogels, and the effect of the addition of these synthetic particles on the viscoelastic and microstructural properties of the biomaterials was evaluated. Experimental results indicated that the incorporation of both types of polymeric particles to fibrin-agarose scaffolds was able to improve the biomechanical properties of the biomaterials under steady state and oscillatory shear stresses, resulting in scaffolds characterized by higher values of the storage, loss and shear moduli...
October 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29051880/an-exceptional-case-of-suture-granuloma-30-years-following-an-open-repair-of-achilles-tendon-rupture-a-case-report
#10
Ömer Naci Ergin, Mehmet Demirel, Emre Özmen
INTRODUCTION: Rupture of the Achilles' tendon is a common injury occurring particularly in middle-aged men due to sports trauma. Operative treatment is preferred generally due to lower risk of re-rupture. Possible complications of the operation include suture granulomas. Suture granulomas might represent a foreign body reaction, which itself is the end-stage response of the inflammatory wound-healing process to biomaterials. It may occur with both absorbable and non-absorbable suture materials such as silk in our case...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051519/from-porous-to-dense-nanostructured-%C3%AE-ti-alloys-through-high-pressure-torsion
#11
Conrado R M Afonso, Angelica Amigó, Vladimir Stolyarov, Dmitri Gunderov, Vicente Amigó
β-Ti alloys have low elastic modulus, good specific strength and high corrosion resistance for biomaterial applications. Noble elements, such as Nb, Ta and Mo, are used to obtain β-Ti due to their chemical biocompatibility. However, due to their refractory nature, β-Ti requires specific processing routes. Powder metallurgy (P/M) allows for the development of new β-Ti alloys with decreasing costs, but dealing with high-elemental-content alloys can lead to a lack of diffusion and grain growth. One method to refine the structure and improve mechanical properties is a severe plastic deformation technique through high-pressure torsion (HPT)...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050594/novel-bioactive-surface-functionalization-of-bacterial-cellulose-membrane
#12
Wei Shao, Jimin Wu, Hui Liu, Shan Ye, Lei Jiang, Xiufeng Liu
Bacterial cellulose (BC) membrane is a promising biopolymer which can be used for tissue implants, wound healing, and drug delivery due to its unique properties, such as high crystallinity, high mechanical strength, ultrafine fiber network structure, good water holding capacity and biocompatibility. However, BC does not intrinsically present antibacterial properties. In the present study, functionalized BC membranes were prepared. FTIR, SEM and XPS were used to characterize the chemical composition and surface morphology...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29050582/ph-sensitive-carboxymethyl-chitosan-hydrogels-via-acid-labile-ortho-ester-linkage-for-potential-biomedical-applications
#13
Liefeng Hu, Panpan Zhang, Xin Wang, Xu Cheng, Jiejie Qin, Rupei Tang
Hydrogel systems with favorable biocompatibility and biodegradability are of much interest for application in biomaterials and tissue engineering. In this study, a new ortho ester-based acid-labile crosslink agent with dual-epoxy end groups was synthesized and crosslinked with carboxymethyl chitosan (CMCS) at different molar ratios to prepare a series of pH-sensitive hydrogels for drug delivering. Doxorubicin (DOX) was then readily loaded into the hydrogels and the in vitro release profiles indicated that the release rate increased rapidly while pH decreased from 7...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29050544/editorial-nanotechnology-and-biomaterials-for-cell-and-drug-therapy
#14
EDITORIAL
Loredana De Bartolo, Simona Salerno
No abstract text is available yet for this article.
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29049304/investigation-of-surface-topography-and-stiffness-on-adhesion-and-neurites-extension-of-pc12-cells-on-crosslinked-silica-aerogel-substrates
#15
Kyle J Lynch, Omar Skalli, Firouzeh Sabri
Fundamental understanding and characterization of neural response to substrate topography is essential in the development of next generation biomaterials for nerve repair. Aerogels are a new class of materials with great potential as a biomaterial. In this work, we examine the extension of neurites by PC12 cells plated on matrigel-coated and collagen-coated mesoporous aerogel surfaces. We have successfully established the methodology for adhesion and growth of PC12 cells on polyurea crosslinked silica aerogels...
2017: PloS One
https://www.readbyqxmd.com/read/29049142/13-93b3-bioactive-glass-a-new-scaffold-for-transplantation-of-stem-cell-derived-chondrocytes
#16
Kivanc Gunhan, Serkan Bariskan, Uzdan Uz, Seda Vatansever, Mujde Kivanc
Research using animal models gives human trials hope for recovery in many fields of regenerative medicine, although they are sometimes poor predictors for human experiences. Our goal was to investigate whether rat chondrocytes, differentiated from adipose-derived stem cells, could be transplanted using a new, easily shaped, bioactive glass scaffold, and to show the immunohistochemical results. Intraperitoneal and retroperitoneal adipose tissue was extracted from 6 male Wistar albino type rats. The fatty tissue samples were fragmented and incubated...
October 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29048702/time-kill-assays-of-amphotericin-b-plus-anidulafungin-against-candida-tropicalis-biofilms-formed-on-two-different-biomaterials
#17
Marcelo E Fernández-Rivero, José L Del Pozo, Paula Ramírez, Eulogio Valentín, Alba Ruiz-Gaitán, Javier Pemán, Emilia Cantón
PURPOSE: To determine the fungicidal activity by time-killing assays of amphotericin B (AMB) combined with anidulafungin (ANF) against biofilms of 2 clinical isolates of Candida tropicalis and the reference strain ATCC® 750, developed on polytetrafluoroethylene (PTFE) and titanium, using the CDC Biofilm Reactor (CBR) as an in vitro model. METHODS: Biofilms were developed for 24 hours on the disk surfaces and then exposed to AMB (40 mg/L), ANF (8 mg/L), alone and combined...
October 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29048075/fluorescence-properties-of-doxorubicin-coupled-carbon-nanocarriers
#18
Najmeh Sadat Hosseini Motlagh, Parviz Parvin, Mitra Refahizadeh, Ali Bavali
The effect of graphene oxide (GO) and nanodiamond (ND) is investigated on the spectral properties of doxorubicin (DOX) fluorescence emissions in the form of (DOX+GO) and (DOX+ND) biomaterials. It is shown that carbon nanostructure additives lead to sensible blueshifts, due to their optical properties and surface functionality. The quenching coefficient KND is obtained to be KND=0.043  (μg/ml)(-1) and KGO=0.342  (μg/ml)(-1) in DOX solutions. In general, Stern-Volmer attests that excited (DOX+GO) strongly quenches with respect to that of (DOX+ND) regarding its privileged bonding affinity...
September 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047206/determining-the-cross-talk-between-smooth-muscle-cells-and-macrophages-on-a-cobalt-chromium-stent-material-surface-using-an-in-vitro-post-implantation-co-culture-model
#19
Jordan A Anderson, Sujan Lamichhane, Thomas Vierhout, Daniel Engebretson
Smooth muscle cells (SMCs) and macrophages are important cellular components involved in the development of complications following the implantation of cardiovascular devices. This leads to various disorders such as restenosis, chronic inflammation, and may ultimately result in device failure. In this study, we developed a post-implant stent co-culture model using different ratios of SMCs and macrophages seeded on to cobalt-chromium alloy. The macrophages had an increased affinity to the co-culture surfaces, which resulted in decreased SMC attachment to the alloy surfaces at the initial time point...
October 19, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29046907/bladder-regeneration-in-a-canine-model-using-a-bladder-acellular-matrix-loaded-with-a-collagen-binding-bfgf
#20
Chunying Shi, Wei Chen, Bing Chen, Tao Shan, Weisheng Jia, Xianglin Hou, Longkun Li, Gang Ye, Jianwu Dai
Bladder reconstruction remains challenging for urological surgery due to lack of suitable regenerative scaffolds. In a previous study, we had used a collagen-binding basic fibroblast growth factor (CBD-bFGF) to bind bFGF to the collagen scaffold, which could promote bladder regeneration in rats. However, the limited graft size in rodent models cannot provide enough evidence to demonstrate the repair capabilities of this method for severely damaged bladders in humans or large animals. In this study, the CBD-bFGF was used to activate a bladder acellular matrix (BAM) scaffold, and the CBD-bFGF/BAM functional scaffold was assessed in a canine model with a large segment defect (half of the entire bladder was resected)...
October 19, 2017: Biomaterials Science
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