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https://www.readbyqxmd.com/read/28550360/bioprinting-technologies-for-disease-modeling
#1
REVIEW
Adnan Memic, Ali Navaei, Bahram Mirani, Julio Alvin Vacacela Cordova, Musab Aldhahri, Alireza Dolatshahi-Pirouz, Mohsen Akbari, Mehdi Nikkhah
There is a great need for the development of biomimetic human tissue models that allow elucidation of the pathophysiological conditions involved in disease initiation and progression. Conventional two-dimensional (2D) in vitro assays and animal models have been unable to fully recapitulate the critical characteristics of human physiology. Alternatively, three-dimensional (3D) tissue models are often developed in a low-throughput manner and lack crucial native-like architecture. The recent emergence of bioprinting technologies has enabled creating 3D tissue models that address the critical challenges of conventional in vitro assays through the development of custom bioinks and patient derived cells coupled with well-defined arrangements of biomaterials...
May 26, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28550302/antigenicity-of-bovine-pericardium-determined-by-a-novel-immunoproteomic-approach
#2
Katherine V Gates, Ailsa J Dalgliesh, Leigh G Griffiths
Despite bovine pericardium (BP) being the primary biomaterial used in heart valve bioprostheses, recipient graft-specific immune responses remain a significant cause of graft failure. Consequently, tissue antigenicity remains the principal barrier for expanding use of such biomaterials in clinical practice. We hypothesize that our understanding of BP antigenicity can be improved by application of a combined affinity chromatography shotgun immunoproteomic approach to identify antigens that have previously been overlooked...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28549587/neuronally-differentiated-adipose-derived-stem-cells-and-aligned-phbv-nanofiber-nerve-scaffolds-promote-sciatic-nerve-regeneration
#3
Feihu Hu, Xiaofeng Zhang, Haixia Liu, Peng Xu, Doulathunnisa, Gaojun Teng, Zhongdang Xiao
Through a combination of biomaterials and stem cells, tissue engineering strategies for restoring and regenerating damaged peripheral nerves have recently been used to meet the challenges posed by nerve injury. In a previous study, we revealed a new way to induce neuronal differentiation of stem cells based on the temporally sequential use of miR-218 and Fibroblast Growth Factor 2 (FGF2) in vitro (FGF2-miR-218 induction approach). In the present study, we sought to investigate the application of this novel approach in repairing sciatic nerve damage in vivo...
May 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28547896/assembly-of-breast-cancer-heterotypic-spheroids-on-hyaluronic-acid-coated-surfaces
#4
Marco P Carvalho, Elisabete C Costa, Ilídio J Correia
Drug screening is currently demanding for realistic models that are able to reproduce the structural features of solid tumors. 3D cell culture systems, namely spheroids, emerged as a promising approach to provide reliable results during drug development. So far, Liquid Overlay Technique (LOT) is one of the most used methods for spheroids assembly. It comprises cellular aggregation due to their limited adhesion to certain biomaterials, like agarose. However, researchers are currently improving this technique in order to obtain spheroids on surfaces that mimic cancer extracellular matrix (ECM), since cell-ECM interactions modulate cells behavior and their drug resistance profile...
May 25, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28547877/comparative-study-of-osteogenic-activity-of-multilayers-made-of-synthetic-and-biogenic-polyelectrolytes
#5
Deepak Guduru, Marcus S Niepel, Cristina Gonzalez-Garcia, Manuel Salmeron-Sanchez, Thomas Groth
Polyelectrolyte multilayer (PEM) coatings on biomaterials are applied to tailor adhesion, growth, and function of cells on biomedical implants. Here, biogenic and synthetic polyelectrolytes (PEL) are used for layer-by-layer assembly to study the osteogenic activity of PEM with human osteosarcoma MG-63 cells in a comparative manner. Formation of PEM is achieved with biogenic PEL fibrinogen (FBG) and poly-l-lysine (PLL) as well as biotinylated chondroitin sulfate (BCS) and avidin (AVI), while poly(allylamine hydrochloride) (PAH) and polystyrene sulfonate (PSS) represent a fully synthetic PEM used as a reference system here...
May 26, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28546955/biofabrication-and-biomaterials-for-urinary-tract-reconstruction
#6
REVIEW
Moustafa M Elsawy, Achala de Mel
Reconstructive urologists are constantly facing diverse and complex pathologies that require structural and functional restoration of urinary organs. There is always a demand for a biocompatible material to repair or substitute the urinary tract instead of using patient's autologous tissues with its associated morbidity. Biomimetic approaches are tissue-engineering tactics aiming to tailor the material physical and biological properties to behave physiologically similar to the urinary system. This review highlights the different strategies to mimic urinary tissues including modifications in structure, surface chemistry, and cellular response of a range of biological and synthetic materials...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28544963/fibronectin-based-multilayer-thin-films
#7
Adeline Gand, Maud Tabuteau, Coline Chat, Guy Ladam, Hassan Atmani, Paul R Van Tassel, Emmanuel Pauthe
Thin films mimicking the structure and composition of the extra-cellular matrix (ECM) are potentially attractive as biomaterials for cell contacting applications. Layer-by-layer (LbL) assembly of a biological polycation, poly(l-lysine) (PLL), and a common ECM protein, fibronectin (Fn), was employed here to construct nanoscale, ECM mimicking films. Incremental film thickness and interfacial charge magnitude are observed to diminish with layer number, resulting in sub-linear film growth scaling and saturation after about 10 layers...
May 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28544961/superficial-physicochemical-properties-of-polyurethane-biomaterials-as-osteogenic-regulators-in-human-mesenchymal-stem-cells-fates
#8
Mohsen Shahrousvand, Gity Mir Mohamad Sadeghi, Ehsan Shahrousvand, Marzieh Ghollasi, Ali Salimi
All of the cells' interactions are done through their surfaces. Evaluation of surface physicochemical scaffolds along with other factors is important and determines the fate of stem cells. In this work, biodegradable and biocompatible polyester/polyether based polyurethanes (PUs) were synthesized by polycaprolactone diol (PCL) and poly (tetra methylene ether) glycol (PTMEG) as the soft segment. To assess better the impact of surface parameters such as stiffness and roughness effects on osteogenic differentiation of the human mesenchymal stem cell (hMSC), the dimension effect of substrates was eliminated and two-dimensional membranes were produced by synthesized polyurethane...
May 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28544779/a-brief-review-of-extrusion-based-tissue-scaffold-bio-printing
#9
REVIEW
Liqun Ning, Xiongbiao Chen
Extrusion-based bio-printing has great potential as a technique for manipulating biomaterials and living cells to create three-dimensional (3D) scaffolds for damaged tissue repair and function restoration. Over the last two decades, advances in both engineering techniques and life sciences have evolved extrusion-based bio-printing from a simple technique to one able to create diverse tissue scaffolds from a wide range of biomaterials and cell types. However, the complexities associated with synthesis of materials for bio-printing and manipulation of multiple materials and cells in bio-printing pose many challenges for scaffold fabrication...
May 24, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28544743/deconvoluting-the-bioactivity-of-calcium-phosphate-based-bone-graft-substitutes-strategies-to-understand-the-role-of-individual-material-properties
#10
REVIEW
Víctor Pablo Galván-Chacón, Pamela Habibovic
Calcium phosphate (CaP)-based ceramics are the most widely applied synthetic biomaterials for repair and regeneration of damaged and diseased bone. CaP bioactivity is regulated by a set of largely intertwined physico-chemical and structural properties, such as the surface microstructure, surface energy, porosity, chemical composition, crystallinity and stiffness. Unravelling the role of each individual property in the interaction between the biomaterial and the biological system is a prerequisite for evolving from a trial-and-error approach to a design-driven approach in the development of new functional biomaterials...
May 23, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28544655/3d-bioprinting-human-induced-pluripotent-stem-cell-constructs-for-in-situ-cell-proliferation-and-successive-multilineage-differentiation
#11
Qi Gu, Eva Tomaskovic-Crook, Gordon G Wallace, Jeremy M Crook
The ability to create 3D tissues from induced pluripotent stem cells (iPSCs) is poised to revolutionize stem cell research and regenerative medicine, including individualized, patient-specific stem cell-based treatments. There are, however, few examples of tissue engineering using iPSCs. Their culture and differentiation is predominantly planar for monolayer cell support or induction of self-organizing embryoids (EBs) and organoids. Bioprinting iPSCs with advanced biomaterials promises to augment efforts to develop 3D tissues, ideally comprising direct-write printing of cells for encapsulation, proliferation, and differentiation...
May 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28544508/enhancement-of-plasma-protein-adsorption-and-osteogenesis-of-hmscs-by-functionalized-siloxane-coatings-for-titanium-implants
#12
Maria Martínez-Ibáñez, N Sanjeeva Murthy, Yong Mao, Julio Suay, Marilo Gurruchaga, Isabel Goñi, Joachim Kohn
A series of sol-gel derived silicon based coatings were developed to improve the osseointegration of commercial titanium dental implants. The osseointegration starts with a positive interaction between the implant surface and surrounding tissues, which is facilitated by the adsorption of plasma proteins onto the biomaterial surface immediately after implantation. It is likely that the enhancement of protein adsorption to titanium implants leads to a better implant/tissue integration. In addition, silica based biomaterials have been shown to promote osteoblast differentiation...
May 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28544348/galectin-1-promotes-an-m2-macrophage-response-to-polydioxanone-scaffolds
#13
Daniel Abebayehu, Andrew Spence, Barbara D Boyan, Zvi Schwartz, John J Ryan, Michael J McClure
Regulating soft tissue repair to prevent fibrosis and promote regeneration is central to creating a microenvironment conducive to soft tissue development. Macrophages play an important role in this process. Their response can be modulated using biomaterials, altering cytokine and growth factor secretion to promote regeneration. Electrospun polydioxanone (PDO) fiber scaffolds promoted an M2 phenotype when macrophages were cultured on large diameter, highly porous scaffolds, but an M1 phenotype on smaller diameter fibers...
May 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28542343/bone-marrow-cell-extract-promotes-the-regeneration-of-irradiated-bone
#14
Guillaume Michel, Pauline Blery, Michaël Henoux, Jérôme Guicheux, Pierre Weiss, Sophie Brouard, Olivier Malard, Florent Espitalier
Mandibular osteoradionecrosis is a severe side effect of radiotherapy after the treatment of squamous cell carcinomas of the upper aerodigestive tract. As an alternative to its treatment by micro-anastomosed free-flaps, preclinical tissular engineering studies have been developed. Total bone marrow (TBM) associated with biphasic calcium phosphate (BCP) significantly enhanced bone formation in irradiated bone. One mechanism, explaining how bone marrow cells can help regenerate tissues like this, is the paracrine effect...
2017: PloS One
https://www.readbyqxmd.com/read/28540302/the-elasticity-coefficients-measurement-of-human-dentin-based-on-rus
#15
Fan Fan, Dandan Feng, Rui Wang, Qiang Zhang, Haijun Niu
This paper proposed to take advantages of resonant ultrasound spectroscopy (RUS) to measure the mechanical properties of human dentin specimen. The resonant spectroscopy of the dentin specimen was obtained between the frequency bands 155 and 575 kHz, and resonant frequencies were extracted by linear predictive filter and then by Levenberg-Marquardt method. By inverse problem approach, 13 experimental resonant frequencies progressively matched to the first 30 orders of theoretical resonant frequencies calculated by Lagrangian variational method...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28540030/human-platelet-rich-plasma-improves-the-nesting-and-differentiation-of-human-chondrocytes-cultured-in-stabilized-porous-chitosan-scaffolds
#16
Maria Sancho-Tello, Sara Martorell, Manuel Mata Roig, Lara Milián, M A Gámiz-González, Jose Luis Gómez Ribelles, Carmen Carda
The clinical management of large-size cartilage lesions is difficult due to the limited regenerative ability of the cartilage. Different biomaterials have been used to develop tissue engineering substitutes for cartilage repair, including chitosan alone or in combination with growth factors to improve its chondrogenic properties. The main objective of this investigation was to evaluate the benefits of combining activated platelet-rich plasma with a stabilized porous chitosan scaffold for cartilage regeneration...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28539887/biomaterials-for-local-controlled-drug-delivery-to-the-injured-spinal-cord
#17
REVIEW
Alexis M Ziemba, Ryan J Gilbert
Affecting approximately 17,000 new people each year, spinal cord injury (SCI) is a devastating injury that leads to permanent paraplegia or tetraplegia. Current pharmacological approaches are limited in their ability to ameliorate this injury pathophysiology, as many are not delivered locally, for a sustained duration, or at the correct injury time point. With this review, we aim to communicate the importance of combinatorial biomaterial and pharmacological approaches that target certain aspects of the dynamically changing pathophysiology of SCI...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28539292/-gelatin-alginate-hydrogel-scaffolds-prepared-by-3d-bioprinting-promotes-cell-adhesion-and-proliferation-of-human-dental-pulp-cells-in-vitro
#18
Hai-Yue Yu, Dan-Dan Ma, Bu-Ling Wu
OBJECTIVE: To evaluate the cytotoxicity of gelatin/alginate hydrogel scaffolds prepared by 3D bioprinting in human dental pulp cells (HDPCs) and compare the cell adhesion and proliferation of the cells seeded in the biomaterial using two different methods. METHODS: HDPCs isolated by tissue block culture and enzyme digestion were cultured and passaged. Gelatin/alginate hydrogel scaffolds were printed using a bioplotter, and the cytotoxicity of the aqueous extracts of the scaffold material was tested in the third passage of HDPCs using cell counting kit-8...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28539282/-effect-of-polycaprolactone-ascobic-acid-scaffold-in-repairing-articular-cartilage-defects-in-rabbits
#19
Zhi-Hui Huang, Bing Song, Yu-Fan Chen, Zhe-Ting Liao, Liang Zhao
OBJECTIVE: To investigate the effect of polycaprolactone-ascobic acid (PCL-AA) scaffolds in promoting repair of articular cartilage defects in a rabbit model. METHODS: The cartilage defects (3.5 mm in diameter and 3.0 mm in depth) were created in the trochlear groove of the bilateral knees of eight 6-month-old male New Zealand white rabbits. The rabbit models were then randomized into 3 groups to receive implantation of PCL-AA scaffolds (group A, n=8), implantation of PCL scaffolds without AA (group B, n=5), or no treatment (group C, n=3)...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28539184/effects-of-age-related-shifts-in-cellular-function-and-local-microenvironment-upon-the-innate-immune-response-to-implants
#20
REVIEW
Bryan N Brown, Martin J Haschak, Samuel T Lopresti, Elizabeth C Stahl
The host macrophage response is now well recognized as a predictor of the success or failure of biomaterial implants following placement. More specifically, shifts from an "M1" pro-inflammatory towards a more "M2-like" anti-inflammatory macrophage polarization profile have been shown to result in enhanced material integration and/or tissue regeneration downstream. As a result, a number of biomaterials-based approaches to controlling macrophage polarization have been developed. However, the ability to promote such activity is predicated upon an in-depth, context-dependent understanding of the host response to biomaterials...
May 20, 2017: Seminars in Immunology
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