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https://www.readbyqxmd.com/read/29454236/stingel-controlled-release-of-a-cyclic-dinucleotide-for-enhanced-cancer-immunotherapy
#1
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454187/investigating-the-time-dependent-zeta-potential-of-wood-surfaces
#2
Livius F Muff, Thomas Luxbacher, Ingo Burgert, Benjamin Michen
This work reports on streaming potential measurements through natural capillaries in wood and investigates the cause of a time-dependent zeta potential measured during the equilibration of wood cell-walls with an electrolyte solution. For the biomaterial, this equilibration phase takes several hours, which is much longer than for many other materials that have been characterized by electrokinetic measurements. During this equilibration phase the zeta potential magnitude is decaying due to two parallel mechanisms: (i) the swelling of the cell-wall which causes a dimensional change reducing the charge density at the capillary interface; (ii) the transport of ions from the electrolyte solution into the permeable cell-wall which alters the electrical potential at the interface by internal charge compensation...
February 7, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29453815/the-use-of-chitosan-porous-3d-scaffolds-embedded-with-resolvin-d1-to-improve-in-vivo-bone-healing
#3
Daniela P Vasconcelos, Madalena Costa, Nuno Neves, José H Teixeira, Daniel M Vasconcelos, Susana G Santos, Artur P Águas, Mário A Barbosa, Judite N Barbosa
The aim of this study was to investigate the effect chitosan (Ch) porous 3D scaffolds embedded with resolvin D1 (RvD1), an endogenous pro-resolving lipid mediator, on bone tissue healing. These scaffolds previous developed by us have demonstrated to have immunomodulatory properties namely in the modulation of the macrophage inflammatory phenotypic profile in an in vivo model of inflammation. Herein, results obtained in an in vivo rat femoral defect model demonstrated that two months after Ch+RvD1 scaffolds implantation, an increase in new bone formation, in bone trabecular thickness, and in collagen type I and Coll I/Coll III ratio were observed...
February 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29453807/tunable-poly-methacrylic-acid-co-acrylamide-nanoparticles-through-inverse-emulsion-polymerization
#4
Justin X Zhong, John R Clegg, Eric W Ander, Nicholas A Peppas
Environmentally responsive biomaterials have played key roles in the design of biosensors and drug delivery vehicles. Their physical response to external stimuli, such as temperature or pH, can transduce a signal or trigger the release of a drug. In this work, we designed a robust, highly tunable, pH responsive nanoscale hydrogel system. We present the design and characterization of poly((methacrylic acid) - co - acrylamide) hydrogel nanoparticles, crosslinked with methylenebisacrylamide, through inverse emulsion polymerization...
February 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29453366/time-dependent-enhanced-corrosion-of-ti6al4v-in-the-presence-of-h-2-o-2-and-albumin
#5
Yue Zhang, Owen Addison, Fei Yu, Brendy C Rincon Troconis, John R Scully, Alison J Davenport
There is increasing concern regarding the biological consequences of metal release from implants. However, the mechanisms underpinning implant surface degradation, especially in the absence of wear, are often poorly understood. Here the synergistic effect of albumin and H 2 O 2 on corrosion of Ti6Al4V in physiological saline is studied with electrochemical methods. It is found that albumin induces a time-dependent dissolution of Ti6Al4V in the presence of H 2 O 2 in physiology saline. Potentiostatic polarisation measurements show that albumin supresses dissolution in the presence of H 2 O 2 at short times (<24 h) but over longer time periods (120 h) it significantly accelerates corrosion, which is attributed to albumin-catalysed dissolution of the corrosion product layer resulting in formation of a thinner oxide film...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452287/dental-pulp-stem-cell-derived-chondrogenic-cells-demonstrate-differential-cell-motility-in-type-i-and-type-ii-collagen-hydrogels
#6
Li Yao, Nikol Flynn
BACKGROUND CONTEXT: Advances in the development of biomaterials and stem cell therapy provide a promising approach to regenerating degenerated discs. The normal nucleus pulposus (NP) cells exhibit the similar phenotype as chondrocytes. Because dental pulp stem cells (DPSCs) can be differentiated into chondrogenic cells, the DPSCs and DPSCs-derived chondrogenic cells encapsulated in type I and type II collagen hydrogels can potentially be transplanted into degenerated nucleus pulposus (NP) to repair damaged tissue...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29452182/mussel-inspired-fabrication-of-konjac-glucomannan-microcrystalline-cellulose-intelligent-hydrogel-with-ph-responsive-sustained-release-behavior
#7
Lin Wang, Yu Du, Yi Yuan, Ruo-Jun Mu, Jingni Gong, Yongsheng Ni, Jie Pang, Chunhua Wu
Intelligent hydrogels are attractive biomaterials for various applications, however, fabricating a hydrogel with both adequate self-healing ability and mechanical properties remains a challenge. Herein, a series of novel intelligent konjac glucomannan (KGM)/microcrystalline cellulose (MCC) hydrogels were prepared vis the mussel-inspired chemistry. MCC was firstly functionalized by the oxidative polymerization of dopamine, and the intelligent hydrogels were obtained by mixing aqueous solutions of KGM and functionalized MCC (PDMCC)...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29451714/development-of-regenerative-and-flexible-fibroin-based-wound-dressings
#8
Angelica Panico, Federica Paladini, Mauro Pollini
Skin injuries represent a health problem with consequences in terms of morbidity, disability and life quality. Numerous strategies have been developed for the treatment of wounds, including skin substitutes, biomembranes, scaffolds, and smart dressings. The excellent properties of fibroin can be exploited for the development of advanced wound dressing biomaterials, aiming at promoting the wound healing process. In this work, silk fibroin films modified through the addition of glucose were developed to enhance flexibility of medical device without affecting the biocompatibility, to promote wound healing and to improve the patient well-being...
February 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29451575/functionalized-cu-3-bis-3-nanoparticles-for-dual-modal-imaging-and-targeted-photothermal-photodynamic-therapy
#9
Yanke Wang, Dongdong Cai, Huixia Wu, Yu Fu, Yang Cao, Yingjian Zhang, Dongmei Wu, Qiwei Tian, Shiping Yang
Multifunctional nano-biomaterials with the integration of diagnostic and therapeutic functions have shown great promise in improving the efficacy of cancer therapy. Herein, a new nanoplatform based on functionalized Cu 3 BiS 3 nanoparticles (NPs) is fabricated for tumour-targeted combination phototherapy. The as-synthesized hydrophobic Cu 3 BiS 3 NPs are modified with DSPE-PEG/DSPE-PEG-NH 2 , followed by the conjugation of the photosensitizer chlorin e6 (Ce6) and the target ligand folic acid (FA). The introduced Ce6 can further form a chelate complex with Gd 3+ ...
February 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29450919/looking-into-the-future-toward-advanced-3d-biomaterials-for-stem-cell-based-regenerative-medicine
#10
REVIEW
Zhongmin Liu, Mingliang Tang, Jinping Zhao, Renjie Chai, Jiuhong Kang
Stem-cell-based therapies have the potential to provide novel solutions for the treatment of a variety of diseases, but the main obstacles to such therapies lie in the uncontrolled differentiation and functional engraftment of implanted tissues. The physicochemical microenvironment controls the self-renewal and differentiation of stem cells, and the key step in mimicking the stem cell microenvironment is to construct a more physiologically relevant 3D culture system. Material-based 3D assemblies of stem cells facilitate the cellular interactions that promote morphogenesis and tissue organization in a similar manner to that which occurs during embryogenesis...
February 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29449596/heparan-sulfates-facilitate-harmless-amyloidogenic-fibril-formation-interacting-with-elastin-like-peptides
#11
Federica Boraldi, Pasquale Moscarelli, Brigida Bochicchio, Antonietta Pepe, Anna M Salvi, Daniela Quaglino
Heparan sulfates (HSs) modulate tissue elasticity in physiopathological conditions by interacting with various matrix constituents as tropoelastin and elastin-derived peptides. HSs bind also to protein moieties accelerating amyloid formation and influencing cytotoxic properties of insoluble fibrils. Interestingly, amyloidogenic polypeptides, despite their supposed pathogenic role, have been recently explored as promising bio-nanomaterials due to their unique and interesting properties. Therefore, we investigated the interactions of HSs, obtained from different sources and exhibiting various degree of sulfation, with synthetic amyloidogenic elastin-like peptides (ELPs), also looking at the effects of these interactions on cell viability and cell behavior using in vitro cultured fibroblasts, as a prototype of mesenchymal cells known to modulate the soft connective tissue environment...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449583/mesoporous-silica-nanocarriers-encapsulated-antimalarials-with-high-therapeutic-performance
#12
Saliu Alao Amolegbe, Yui Hirano, Joseph Oluwatope Adebayo, Olusegun George Ademowo, Elizabeth Abidemi Balogun, Joshua Ayoola Obaleye, Antoniana Ursine Krettli, Chengzhong Yu, Shinya Hayami
The use of nanocarriers in drug delivery is a breakeven research and has received a clarion call in biomedicine globally. Herein, two newly nano-biomaterials: MCM-41 encapsulated quinine (MCM-41 ⊃ QN) (1) and 3-phenylpropyl silane functionalized MCM-41 loaded QN (pMCM-41 ⊃ QN) (2) were synthesized and well characterized. 1 and 2 along with our two already reported nano-antimalarial drugs (MCM-41 ⊃ ATS) (3) and 3-aminopropyl silane functionalized MCM-41 contained ATS (aMCM-41 ⊃ ATS) (4) were screened in vitro for their activity against P...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449216/adjustable-delivery-of-pro-angiogenic-fgf-2-by-collagen-alginate-microspheres
#13
Zaheer Ali, Anik Islam, Peter Sherrell, Mark Le-Moine, Georgios Lolas, Konstantinos Syrigos, Mehrdad Rafat, Lasse D Jensen
Therapeutic induction of blood vessel growth (angiogenesis) in ischemic tissues holds great potential for treatment of myocardial infarction and stroke. Achieving sustained angiogenesis and vascular maturation has, however, been highly challenging. Here we demonstrate that collagen:alginate hydrogels containing therapeutic, pro-angiogenic FGF-2, and formulated as microspheres, is a promising and clinically relevant vehicle for therapeutic angiogenesis. By titrating the amount of readily dissolvable and degradable collagen with more slowly degradable alginate in the hydrogel mixture, the degradation rates of the biomaterial controlling the release kinetics of embedded pro-angiogenic FGF-2 can be adjusted...
February 15, 2018: Biology Open
https://www.readbyqxmd.com/read/29449086/progress-in-the-use-of-dental-pulp-stem-cells-in-regenerative-medicine
#14
REVIEW
Eduardo Anitua, María Troya, Mar Zalduendo
The field of tissue engineering is emerging as a multidisciplinary area with promising potential for regenerating new tissues and organs. This approach requires the involvement of three essential components: stem cells, scaffolds and growth factors. To date, dental pulp stem cells have received special attention because they represent a readily accessible source of stem cells. Their high plasticity and multipotential capacity to differentiate into a large array of tissues can be explained by its neural crest origin, which supports applications beyond the scope of oral tissues...
February 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29449015/rapid-initiation-of-guided-bone-regeneration-driven-by-spatiotemporal-delivery-of-il-8-and-bmp-2-from-hierarchical-mbg-based-scaffold
#15
Dan Lin, Yanjun Chai, Yifan Ma, Bing Duan, Yuan Yuan, Changsheng Liu
Initiation of endogenous repair mechanisms, including key steps of stem cell recruitment and cartilage intermediate formation in endochondral ossification, is vital to regeneration of large bone defects. To biomimetically promote a rapid initiation and ensuing osteogenic stimulation, exogenous chemokine IL-8 and growth factor BMP-2 were orchestrated in a mesoporous bioactive glass (MBG)-based spatiotemporal delivery system, to achieve a rapid release of IL-8 followed by a long-term sustained release of BMP-2...
November 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/29448839/role-of-growth-factors-and-biomaterials-in-wound-healing
#16
Farshad Zarei, Maryam Soleimaninejad
Wound healing is a biological complex process that involves several cell types under the control and regulation of several growth factors and cytokines. There have been efforts to study the therapeutic effects of granulocyte-macrophage colony-stimulating factor, platelet-derived growth factor, transforming growth factor-β, vascular endothelial growth factor and basic fibroblast growth factor on chronic wounds. In addition, the effects of biomaterials such as nano-fibrous chitin and chitosan have been proven to be effective on wound healing...
February 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29448503/construction-and-characterization-of-cell-penetrating-peptide-fused-fibroblast-growth-factor-and-vascular-endothelial-growth-factor-for-an-enhanced-percutaneous-delivery-system
#17
Sang Won Choi, Rudra Pangeni, Dai Hyun Jung, Su Jung Kim, Jin Woo Park
The exogenous administration of growth factors has been examined for treating wounds and such factors serve as cosmetic agents for skin regeneration. However, the topical application of growth factors is hampered by their limited percutaneous absorption. In this study, we genetically modified basic fibroblast growth factor (bFGF) and vascular endothelial growth factor-A (VEGF-A) using a cell-penetrating peptide to facilitate their permeation into skin and to avoid multiple steps in the chemical or physical modification of biomaterials...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448502/-in-vitro-mechanical-performance-study-of-biodegradable-polylactic-acid-hydroxyapatite-nanocomposites-for-fixation-medical-devices
#18
Jinsu Park, Bae-Jung Kim, Ji-Yeong Hwang, Yo-Woong Yoon, Hoon-Sang Cho, Dong-Hyun Kim, Jong Kook Lee, Seog-Young Yoon
Osteoconductive, biocompatible, and resorbable organic/inorganic composites are most commonly used in fixation medical devices, such as suture anchors and interference screws, because of their unique physical and chemical properties. Generally, studies on biodegradable composites have focused on their mechanical properties based on the composition and the individual roles of organic and inorganic biomaterials. In this study, we prepared biodegradable organic/inorganic nanocomposite materials using the solvent mixing process and conventional molding...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448143/adsorption-force-of-fibronectin-controls-transmission-of-cell-traction-force-and-subsequent-stem-cell-fate
#19
Manping Lin, Shilong Mao, Jinfeng Wang, Juan Xing, Yuanliang Wang, Kaiyong Cai, Yanfeng Luo
The transmission of cell traction force (CTF) to underlying biomaterials is essential for adhered cells to measure and respond to their mechanical microenvironment. Given that the protein layer adsorbed on materials lies between the cells and materials, we hypothesize that the interfacial strength of protein-material interfaces (i.e., the adsorption force of proteins, F ad ) should have an important role in regulating the transmission of CTF. To test this hypothesis, rat mesenchymal stem cells (rMSCs) were cultured on poly(dimethyl siloxane) (PDMS) substrates with different F ad of fibronectin (FN), and the transmission of CTF was observed by immunofluorescence staining of FN and deformation of PDMS...
February 12, 2018: Biomaterials
https://www.readbyqxmd.com/read/29447471/anti-infection-silver-nanoparticle-immobilized-biomaterials-facilitated-by-argon-plasma-grafting-technology
#20
Ashwin Ambi, Nisharg Parikh, Carolina Vera, Krystal Burns, Naidel Montano, Leonard Sciorra, Jessica Epstein, Debing Zeng, Christian Traba
Many research groups have attained slow, persistent, continuous release of silver ions through careful experimental design using existing methods. Such methods effectively kill planktonic bacteria and therefore prevent surface adhesion of pathogens. However, the resultant modified coatings cannot provide long-term antibacterial efficacy due to sustained anti-microbial release. In this study, the anti-infection activity of AgNP immobilized biomaterials was evaluated, facilitated by argon plasma grafting technology and activated by bacterial colonization...
February 15, 2018: Biofouling
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