keyword
https://read.qxmd.com/read/38527250/hemorrhagic-strokes-attributable-to-chronic-alcohol-consumption-and-heavy-episodic-drinking-in-france
#21
JOURNAL ARTICLE
Lucas Dufour, Clémence Grave, Christophe Bonaldi, Pierre Joly, Raphaël Andler, Guillemette Quatremere, Viêt Nguyen-Thanh, Valérie Olié, Amélie Gabet
OBJECTIVES: To estimate the number of cases and deaths related to hemorrhagic stroke (HS) attributable to a chronic alcohol consumption and to heavy episodic drinking (HED) in France. METHODS: A population-attributable fraction (PAF) estimation approach was used. Relative risks for HS with alcohol consumption were extracted from the INTERSTROKE study. Levels of alcohol consumption in the French population were collected from the 2017 Health Barometer. Data on HS morbidity and mortality were extracted from the French National Health Data System (SNDS)...
April 23, 2024: Neurology
https://read.qxmd.com/read/38527052/codeine-and-promethazine-exploratory-study-on-lean-or-sizzurp-%C3%A2-using-national-survey-data-and-an-online-forum
#22
JOURNAL ARTICLE
Orrin D Ware, Albert Garcia-Romeu, C Austin Zamarripa, Tamera Hughes, Leeza Wager, Tory Spindle
BACKGROUND: The concoction known as "lean" containing codeine and promethazine, holds a prominent cultural presence and is often referenced in mass media platforms (e.g., music and social media). Surprisingly, there's a scarcity of national data characterizing the use of lean. Therefore, the current study investigated the use of lean using national survey data and online forum participant input, and focused on identifying concurrent substance use, exploring co-administration with other substances (e...
2024: PloS One
https://read.qxmd.com/read/38526942/effectiveness-of-1-year-pemafibrate-treatment-on-steatotic-liver-disease-the-influence-of-alcohol-consumption
#23
JOURNAL ARTICLE
Motoh Iwasa, Ryosuke Sugimoto, Akiko Eguchi, Yasuyuki Tamai, Ryuta Shigefuku, Naoto Fujiwara, Hideaki Tanaka, Yoshinao Kobayashi, Jiro Ikoma, Masahiko Kaito, Hayato Nakagawa
BACKGROUND/AIMS: Pemafibrate is a selective peroxisome proliferator-activated receptor α modulator that improves serum alanine aminotransferase (ALT) in dyslipidemia patients. We previously reported that pemafibrate significantly improves liver function, serum triglyceride (TG) levels and liver stiffness in non-alcoholic fatty liver disease patients, however the influence of alcohol consumption was not considered. Therefore, we explored pemafibrate efficacy in patients with steatotic liver disease (SLD) and alcohol-associated liver disease (ALD)...
March 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526687/five-year-survival-prognosis-of-young-middle-aged-and-elderly-adult-female-invasive-breast-cancer-patients-by-clinical-and-lifestyle-characteristics
#24
JOURNAL ARTICLE
Yu-Tung Teng, Yong Alison Wang, Yaa-Hui Dong, Jason J Liu
PURPOSE: Early-onset breast cancer incidence has been increasing globally and in Taiwan. However, previous studies have not comprehensively examined how clinical and lifestyle characteristics influence the 5-year survival of breast cancer diagnosed at different stages of adulthood. METHODS: We analyzed the Taiwan National Cancer Registry and Cause of Death datasets to understand how clinical factors (including tumor and treatment characteristics) and lifestyle factors (including body mass index, cigarette smoking, and alcohol consumption) were associated with the 5-year survival of 8471 young, 57,695 middle-aged, and 14,074 elderly female adult invasive breast cancer patients respectively diagnosed at age 20-39, 40-64, and ≥ 65 years between 2002 and 2015, with mortality follow-up to 2020...
March 25, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38526678/-substance-use-and-the-usage-of-social-media-computer-games-and-gambling-among-apprentices-at-vocational-schools
#25
JOURNAL ARTICLE
Kirsten Lochbühler, Monika Rossa, Christopher Ebert, Matthis Morgenstern, Nicolas Arnaud, Ludwig Kraus
BACKGROUND: The aim of the current study was to assess the prevalence of the (problematic) consumption of alcohol, tobacco, and cannabis as well as the (problematic) use of social media, e‑products, computer games, and gambling among apprentices. METHOD: Cross-sectional survey of 4591 apprentices at 17 vocational schools from Bavaria, Schleswig-Holstein, and Hamburg. Data was collected using questionnaires between March 2021 and April 2022. The primary endpoints were the 30-day prevalence and the problematic consumption and usage behavior of the mentioned substances/behaviors using screening instruments...
March 25, 2024: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://read.qxmd.com/read/38524862/analysis-of-dietary-and-nutritional-status-of-tuberculosis-patients-in-hulunbuir-region
#26
JOURNAL ARTICLE
Jin-Qi Hao, Lan Zhang, Yan-Qin Yu, Ming-Yuan Hao, Ai-Xin Wang, Fu-Min Feng
OBJECTIVE: Tuberculosis (TB) is a major public health problem that affects millions of people worldwide. Malnutrition is a common complication of TB and can worsen the disease outcome. The purpose of this study was to investigate the dietary and nutritional status, as well as the dietary structure, of TB patients in Hulunbuir City, Inner Mongolia, China. Additionally, the study aimed to analyze the factors that influence the nutritional status in order to provide a theoretical foundation for the prevention and treatment of TB and related issues...
2024: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/38524847/epigenetic-regulation-of-microglia-and-neurons-by-proinflammatory-signaling-following-adolescent-intermittent-ethanol-aie-exposure-and-in-human-aud
#27
REVIEW
Fulton T Crews, Victoria Macht, Ryan P Vetreno
Adolescent alcohol drinking is linked to high rates of adult alcohol problems and alcohol use disorder (AUD). The Neurobiology of Alcohol Drinking in Adulthood (NADIA) consortium adolescent intermittent ethanol (AIE) models adolescent binge drinking, followed by abstinent maturation to adulthood to determine the persistent AIE changes in neurobiology and behavior. AIE increases adult alcohol drinking and preference, increases anxiety and reward seeking, and disrupts sleep and cognition, all risks for AUD. In addition, AIE induces changes in neuroimmune gene expression in neurons and glia that alter neurocircuitry and behavior...
2024: Adv Drug Alcohol Res
https://read.qxmd.com/read/38523993/non-habit-related-oral-squamous-cell-carcinoma-a-review
#28
REVIEW
Rosalyn Lalremtluangi, Suwarna Dangore-Khasbage
Oral squamous cell carcinoma (OSCC) is a serious and potentially life-threatening condition that can have a profound impact on an individual's health and well-being. Its etiology is commonly known to be habit induced, such as tobacco consumption, smoking, or alcohol abuse. Apart from these etiologies, certain factors that lead to OSCC are also present but are less frequently encountered in hospitals and clinics. However, these non-habitual factors, with their pathogenesis, can lead to OSCC, which may be confusing to certain medical practitioners...
February 2024: Curēus
https://read.qxmd.com/read/38523964/unveiling-the-surge-a-comprehensive-analysis-of-e-scooter-related-injuries-at-an-urban-level-1-trauma-center-in-vilnius-lithuania-2018-2021
#29
JOURNAL ARTICLE
Kristupas A Suslavičius, Simonas Utkus, Valentinas Uvarovas, Tomas Sveikata, Sigitas Ryliškis
Background The surge in electric scooter (e-scooter) adoption in 2019 fueled by sharing platforms has raised safety concerns, leading to an increased incidence of e-scooter-related injuries. Despite regulatory efforts, there has been a notable rise in accidents, prompting a comprehensive investigation. This study conducted at the Republican Vilnius University Hospital (RVUH), a level 1 trauma center, is one of the first in the Baltic States aiming to analyze the causes, severity, and frequency of e-scooter injuries from 2018 to 2021...
February 2024: Curēus
https://read.qxmd.com/read/38523595/alcohol-drinking-dna-methylation-and-psychiatric-disorders-a-multi-omics-mendelian-randomization-study-to-investigate-causal-pathways
#30
JOURNAL ARTICLE
Xiaoqiang Shi, Meng Li, Jianhua Yao, Ming D Li, Zhongli Yang
BACKGROUND AND AIMS: Whether alcohol-related DNA methylation has a causal effect on psychiatric disorders has not been investigated. Furthermore, a comprehensive investigation into the causal relationship and underlying mechanisms linking alcohol consumption and psychiatric disorders has been lacking. This study aimed to evaluate the causal effect of general alcohol intake and pathological drinking behaviors on psychiatric disorders, alcohol-associated DNA methylation on gene expression and psychiatric disorders, and gene expression on psychiatric disorders...
March 25, 2024: Addiction
https://read.qxmd.com/read/38523428/promoting-the-wellness-of-older-adults-through-integrated-health-promoting-programs-and-supportive-peers-a-quasi-experimental-study-in-semi-urban-communities-of-northeastern-thailand
#31
JOURNAL ARTICLE
Tassanee Silawan, Arpaporn Powwattana, Phurithat Ponsen, Nuttawat Ninkarnjanakun
INTRODUCTION/OBJECTIVES: Thailand has approached an aged society in which the proportion of older adults rose from 5% in 1995 to 20.7% in 2022 and is projected to increase to 27.2% in 2030. Older adults face health risks and challenges, requiring supportive care. This research aimed to promote the wellness of older adults through Integrated Health-Promoting Programs and Supportive Peers (IHPP-SP) in semi-urban communities. METHODS: A one-group pretest-posttest quasi-experimental study was conducted among 229 older adults from 22 communities...
2024: Journal of Primary Care & Community Health
https://read.qxmd.com/read/38523362/screening-for-depression-and-anxiety-in-lung-cancer-patients-a-real-world-study-using-gad-7-and-hads
#32
JOURNAL ARTICLE
Yi Fung Chau, Huixia Zhou, Bolu Chen, Hengqin Ren, Zixiao Ma, Xiangyang Zhang, Jianchun Duan
BACKGROUND: The psychological well-being of lung cancer patients is critical in-patient care but frequently overlooked. METHODS: This study, employing a cross-sectional, questionnaire-based design, aimed to elucidate the prevalence of depressive and anxiety symptoms among lung cancer patients and identify associated risk factors. Participants' demographic, medical history, disease stage, and pathology were systematically collected. Psychological assessment was conducted using the general anxiety disorder-7 (GAD-7), patient health questionnaire-9 (PHQ-9), and hospital anxiety and depression scale (HADS)...
March 24, 2024: Thoracic Cancer
https://read.qxmd.com/read/38522756/the-discovery-of-ggt1-as-a-novel-gene-for-ischemic-stroke-conferring-protection-against-disease-risk-in-non-smokers-and-non-abusers-of-alcohol
#33
JOURNAL ARTICLE
Maria Solodilova, Elena Drozdova, Iuliia Azarova, Elena Klyosova, Marina Bykanova, Olga Bushueva, Anna Polonikova, Mikhail Churnosov, Alexey Polonikov
OBJECTIVES: Increased plasma gamma-glutamyl transferase (GGT1) has been identified as a robust and independent risk factor for ischemic stroke (IS), but the molecular mechanisms of the enzyme-disease association are unclear. The present study investigated whether polymorphisms in the GGT1 gene contribute to IS susceptibility. MATERIALS AND METHODS: DNA samples obtained from 1288 unrelated individuals (600 IS patients and 688 controls) were genotyped for common single nucleotide polymorphisms of GGT1 using the MassArray-4 platform...
March 22, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38522739/associations-between-urinary-concentrations-of-benzothiazole-benzotriazole-and-their-derivatives-and-lung-cancer-a-nested-case-control-study
#34
JOURNAL ARTICLE
Weili Mao, Jianli Qu, Huimeng Liu, Ruyue Guo, Kaizhen Liao, Shaowei Wu, Jin Hangbiao, Zefu Hu
Benzothiazole (BTH), benzotriazole (BTR), and their respective derivatives (BTHs and BTRs) are emerging environmental pollutants with widespread human exposure and oncogenic potential. Studies have demonstrated adverse effects of exposure to certain BTHs and BTRs on the respiratory system. However, no study has examined the associations between exposure to BTHs and BTRs and lung cancer risk. We aimed to examine the associations between urinary concentrations of BTHs and BTRs and the risk of lung cancer in the general population from Quzhou, China...
March 22, 2024: Environmental Research
https://read.qxmd.com/read/38522483/microbiome-interactions-with-different-risk-factors-in-development-of-myocardial-infarction
#35
REVIEW
Manisha Bijla, Sunil Kumar Saini, Ajai Pathak, Kamal Prakash Bharadwaj, Katyayani Sukhavasi, Ayurshi Patil, Diksha Saini, Rakesh Yadav, Shalini Singh, Christiaan Leeuwenburgh, Pramod Kumar
Among all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites...
March 22, 2024: Experimental Gerontology
https://read.qxmd.com/read/38522476/ultra-processed-food-consumption-and-long-term-risk-of-irritable-bowel-syndrome-a-large-scale-prospective-cohort-study
#36
JOURNAL ARTICLE
Shanshan Wu, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang, Shengtao Zhu
BACKGROUND & AIMS: The considerable disease burden of irritable bowel syndrome (IBS) has coincided with the increase of ultraprocessed food (UPF) consumption over the past few decades. However, epidemiologic evidence is lacking. We aimed to examine the long-term risk of IBS associated with UPF consumption in a large-scale prospective cohort. METHODS: Participants who completed 24-hour dietary recalls during 2009 to 2012 from the UK Biobank, and free of IBS, celiac disease, inflammatory bowel disease, and any cancer at baseline, were included (N = 178,711; 53...
March 21, 2024: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/38521977/is-coffee-tea-and-red-wine-consumption-beneficial-for-individuals-with-hypertension
#37
JOURNAL ARTICLE
Shuchen Zhang, Boyang Xiang, Xiangyu Su, Yujia Zhou, Yiheng Zhao, Xiang Zhou
OBJECTIVE: To investigate the associations of tea, coffee, and red wine intakes with health risks among individuals with hypertension. METHODS: This prospective cohort study included participants with hypertension from the UK Biobank cohort. Study exposures included self-reported intakes of coffee, tea, and red wine. The primary outcome was all-cause mortality, and the secondary outcomes were cardiovascular mortality and cardiovascular disease. The associations of beverage intake with outcomes were analyzed using Cox regression models...
March 23, 2024: Postgraduate Medical Journal
https://read.qxmd.com/read/38521936/-you-cannot-stay-with-one-person-once-you-begin-having-sex-at-a-young-age-the-prevalence-correlates-and-effects-of-early-sexual-debut-among-children-in-ghana
#38
JOURNAL ARTICLE
Frank Kyei-Arthur, Martin Wiredu Agyekum, Sylvester Kyei-Gyamfi
BACKGROUND: Children's initiation of early sex has several negative implications on their sexual and reproductive health, growth and development. In Ghana, few studies on early sexual debut have focused on adolescents. Therefore, this study examined the prevalence, causes, correlates and effects of early sexual debut among children aged 8 to 17 in Ghana using secondary data from the Department of Children of the Ministry of Gender, Children, and Social Protection. METHODS: A convergent parallel mixed-method approach guided the study...
March 23, 2024: Reproductive Health
https://read.qxmd.com/read/38521907/occupational-status-and-chronic-respiratory-diseases-a-cross-sectional-study-based-on-the-data-of-the-rafsanjan-cohort-study
#39
JOURNAL ARTICLE
Zahra Bagheri-Hosseinabadi, Ali Bahreyni, Hosein Basirat, Parvin Khalili, Alireza Vakilian, Fatemeh Amin
BACKGROUND: The aim of the present study was to investigate the possible connection between occupational status and chronic respiratory diseases (CRDs) among the Iranian population. METHODS: The present cross-sectional study was conducted on 9934 individuals aged 35-70 years enrolled in the Rafsanjan Cohort Study (RCS), a component of the Prospective Epidemiological Research Studies in Iran (PERSIAN). Detailed questionnaires were used to collect information on various factors, such as occupation, sociodemographic characteristics, medical history, anthropometric measurements, physical activity, cigarette and hookah smoking, opium use, and alcohol consumption...
March 23, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38521730/safety-and-compliance-of-long-term-low-dose-ondansetron-in-alcohol-use-disorder-treatment
#40
JOURNAL ARTICLE
Giovanni Addolorato, Hannu Alho, Paula Bresciani M De Andrade, Otto Michael Lesch, Lei Liu, Bankole Johnson
BACKGROUND: The increasing prevalence of alcohol use disorder (AUD) and the parallel surge in alcohol-associated liver disease (ALD) emphasize the urgent need for comprehensive alcohol management strategies. Low-dose ondansetron (AD04, a 5-HT3 antagonist) was shown recently to be a promising treatment for AUD with a specific genotypic profile (5-marker). The liver safety of AD04 has never been evaluated in subjects with AUD. The aim of the present study was to assess the liver safety profile of AD04 compared with placebo in subjects with AUD...
March 22, 2024: European Journal of Internal Medicine
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