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https://www.readbyqxmd.com/read/28441704/a-study-of-alcohol-consumption-and-obesity-as-main-risk-factor-for-symptomatic-gallbladder-stone-a-case-control-study
#1
Byung Hyo Cha, Ban Seok Lee, Sang Hyub Lee, Seung Joo Kang, Min Jung Park
Background: Gallbladder stone (GBS) is a common gastrointestinal disease that can progress to severe cholecystitis and is a strong risk factor for gallbladder cancer (GBC). The present study was conducted to evaluate region-specific causes of GBS which was proved as major risk factor for GBC in Jeju Island, Korea. Methods: Age and sex match case-control study was performed among 171 pairs of case and controls. The cases were patients who were diagnosed with GBS, had definite clinical symptoms, and underwent a cholecystectomy in Cheju Halla General Hospital, Jeju, Korea during 2010-2014...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441666/a-microrna-124-polymorphism-is-associated-with-fracture-healing-via-modulating-bmp6-expression
#2
Lin Zou, Guichun Zhang, Lifeng Liu, Chen Chen, Xuecheng Cao, Jinfang Cai
BACKGROUND: miR-124-3p has been reported to be involved in the pathogenesis of many diseases by modulating a variety of signaling pathways. In this study, we aimed to understand the impact of miR-124-3p expression level on the fracture healing in the patients of metaphyseal fracture of distal tibia, who received minimal invasive percutaneous plate osteosynthesis. METHODS: We firstly collected 195 patients of metaphyseal fracture of distal tibia, and the genotype of rs531564 was determined: GG (n=124) and GC+CC (n=71)...
April 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28441572/trait-mindfulness-and-protective-strategies-for-alcohol-use-implications-for-college-student-drinking
#3
Emma I Brett, Thad R Leffingwell, Eleanor L Leavens
INTRODUCTION: The use of Protective Behavioral Strategies (PBS) has been strongly linked with decreased experience of alcohol-related consequences, making them a potential target for intervention. Additionally, mindfulness is associated with decreased experience of alcohol-related consequences. The purpose of the current study was to evaluate a model of PBS as a mediator of the effect of mindfulness on alcohol-related consequences. Additionally, mindfulness as a moderator of the relationship between PBS and alcohol use and consequences was examined...
April 8, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28441088/video-enabled-cue-exposure-based-intervention-improves-postdischarge-drinking-outcomes-among-alcohol-dependent-men-a-prospective-study-at-a-government-addiction-treatment-setting-in-india
#4
Prasanthi Nattala, Pratima Murthy, Kit Sang Leung, Sreevani Rentala, Jayashree Ramakrishna
Returning to alcohol use following inpatient treatment occurs due to various real life cues/triggers. It is a challenge to demonstrate to patients how to deal with these triggers during inpatient treatment. Aims of the current study were (a) to evaluate the effectiveness of video-enabled cue-exposure-based intervention (VE-CEI) in influencing treatment outcomes in alcohol dependence, (b) to identify postdischarge predictors of intervention failure (returning to ≥50% of baseline alcohol consumption quantity/day)...
April 25, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28440812/biobehavioral-effects-of-baclofen-in-anxious-alcohol-dependent-individuals-a-randomized-double-blind-placebo-controlled-laboratory-study
#5
M Farokhnia, M L Schwandt, M R Lee, J W Bollinger, L A Farinelli, J P Amodio, L Sewell, T A Lionetti, D E Spero, L Leggio
Baclofen has been suggested as a potential pharmacotherapy for alcohol use disorder, but the clinical data are conflicting. Here we investigated the biobehavioral effects of baclofen in a sample of anxious alcohol-dependent individuals. This was a randomized, double-blind, placebo-controlled, human laboratory study in non-treatment seeking alcohol-dependent individuals with high trait anxiety (N=34). Participants received baclofen (30 mg per day) or placebo for at least 8 days, then performed an experimental session consisting of alcohol cue-reactivity followed by alcohol administration procedure (alcohol priming, then alcohol self-administration)...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28440193/neurocognitive-correlates-in-driving-under-the-influence-of-cannabis
#6
Francesco Paolo Busardò, Manuela Pellegrini, Julia Klein, Natale Mario di Luca
Delta (9)-tetrahydrocannabinol is the main psychoactive compound in cannabis and is commonly identified in blood samples from arrested drivers assumed to drive under the influence of drugs. Changing social norms towards cannabis and higher acceptability towards the drug emphasize the need for comprehensive understanding of the severe neurocognitive and psychomotor effects caused by cannabis and how these effects are correlated to driving skills and performance. In this review, PubMed, Cochrane Central, Scopus, Web of Science, Science Direct and EMBASE databases were used to identify and select publications up to January 2017 dealing with acute and chronic neurocognitive effects induced by cannabis and ability to drive...
April 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28440068/correlates-of-verbal-and-physical-aggression-among-patrons-of-licensed-venues-in-australia
#7
Shannon Hyder, Kerri Coomber, Amy Pennay, Nicolas Droste, Ashlee Curtis, Richelle Mayshak, Tina Lam, William Gilmore, Tanya Chikritzhs, Peter G Miller
INTRODUCTION AND AIMS: The current study aimed to examine the association between patron demographics and substance use, and experiences of verbal and physical aggressive incidents within the last 3 months among patrons of night-time entertainment precincts (NEP) in Australia. DESIGN AND METHODS: Patron interviews (n = 4216) were conducted around licensed venues in the NEPs of five Australian cities. Seven correlates of verbal and physical aggressive incidents were examined: gender, age, occupation, blood alcohol concentration, pre-drinking, energy drink use and illicit drug use in the current session...
April 25, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28439723/psychiatric-comorbidity-in-alcohol-use-disorders-results-from-the-german-s3-guidelines
#8
REVIEW
U W Preuss, E Gouzoulis-Mayfrank, U Havemann-Reinecke, I Schäfer, M Beutel, E Hoch, K F Mann
Alcohol use disorders (AUD) have a high comorbidity with mental disorders. Vice versa, alcohol consumption plays an important role in affective disorders, anxiety disorders, ADHD, schizophrenic psychosis, and other mental disorders. In developing the current interdisciplinary, evidence-based treatment guideline on screening, diagnostics, and treatment of AUD, available research on comorbid mental diseases in AUD has been compiled to generate recommendations for treatment. The guideline was prepared under the responsibility of the German Association for Psychiatry, Psychotherapy, and Psychosomatics (DGPPN) and the German Association for Addiction Research and Therapy (DG-Sucht)...
April 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28439692/the-presence-and-prognostic-significance-of-human-papillomavirus-in-squamous-cell-carcinoma-of-the-larynx
#9
Evren Erkul, Ismail Yilmaz, Gizem Narli, Mustafa Alparslan Babayigit, Atila Gungor, Dilaver Demirel
The aim of the present study was to evaluate the role of HPV in laryngeal squamous cell carcinoma and correlate it with patients' clinicopathological data. In total, 78 laryngeal squamous cell carcinoma patients enrolled in this study. The presence of genotype-specific HPV DNA was evaluated using Genotyping Assay in formalin-fixed paraffin-embedded tissue which was diagnosed between 2005 and 2015. All samples were also evaluated for p16 immunohistochemical staining. HPV DNA and p16 status were assessed in terms of location, smoking, alcohol consumption, lymph node status, tumor stage, overall survival, disease-free survival, perineural invasion, and vascular invasion retrospectively...
April 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28439078/possible-association-between-sirt1-single-nucleotide-polymorphisms-and-predisposition-to-antisocial-personality-traits-in-chinese-adolescents
#10
Hongjuan Chang, Qiuge Yan, Jie Tang, Juan Huang, Yanmei Zhang, Yuqiao Ma, Xiaozhou Ye, Lina Tang, Linguo Wu, Chunxia Wu, Yizhen Yu
Accumulating evidence suggests an association between the SIRT1 gene and human psychiatric disorders. The aim of the study was to investigate the association between SIRT1 and predisposition to antisocial personality traits (ASP) in Chinese adolescents. Participants consisted of 327 controls and 261 juvenile offenders who were diagnosed with predisposition to ASP according to the Personality Diagnostic Questionnaire. Four tag single nucleotide polymorphisms (tagSNPs) of SIRT1, namely rs12778366, rs7896005, rs10823112, and rs4746720, were genotyped...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438247/the-utility-of-the-alcohol-use-disorders-identification-test-audit-for-the-analysis-of-binge-drinking-in-university-students
#11
María T Cortés Tomás, José A Giménez Costa, Patricia Motos-Sellés, María D Sancerni Beitia, Fernando Cadaveira Mahía
BACKGROUND: The increasingly precise conceptualization of Binge Drinking (BD), along with the rising incidence of this pattern of intake amongst young people, make it necessary to review the usefulness of instruments used to detect it. Little evidence exists regarding effectiveness of the AUDIT, AUDIT-C and AUDIT-3 in the detection of BD. This study evaluates their utility in a sample of university students, revealing the most appropriate cut-off points for each sex. METHODS: All students self-administered the AUDIT and completed a self-report of their alcohol consumption...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28437428/prevalence-of-alcohol-use-disorders-among-under-and-post-graduate-healthcare-students-in-italy
#12
Monica Lamberti, Francesco Napolitano, Paola Napolitano, Antonio Arnese, Vincenzo Crispino, Gianclaudio Panariello, Gabriella Di Giuseppe
A cross-sectional study was carried out on 641 medical students, 359 students attending a degree course in the healthcare professions, and 500 resident physicians, all undergoing health surveillance at the ambulatory of the Division of Occupational Medicine, Second University of Naples, Italy. 76.1% of the participants drank alcohol, with 85.5% of medical students, 77.4% of resident physicians, and 63% of healthcare-professions students reporting regular alcohol use. In the whole sample, the mean Audit-C score was 1...
2017: PloS One
https://www.readbyqxmd.com/read/28436272/moderation-of-the-effects-of-discrimination-induced-affective-responses-on-health-outcomes
#13
Meg Gerrard, Frederick X Gibbons, Mary E Fleischli, Carolyn E Cutrona, Michelle L Stock
OBJECTIVE: The goal of the study was to examine differential mediation of long-term effects of discrimination on health behaviour and health status by internalising (anxiety and depression) and externalising (hostility and anger), and to explore moderation of these effects, specifically, by the presence of support networks and coping tendencies. DESIGN: The current analyses employed structural equation modelling of five waves of data from Black female participants of the Family and Community Health Study over 11 years (M age 37-48)...
April 23, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28435127/neural-impact-of-low-level-alcohol-use-on-response-inhibition-an-fmri-investigation-in-young-adults
#14
Taylor Hatchard, Ola Mioduszewski, Carley Fall, Aziza Byron-Alhassan, Peter Fried, Andra M Smith
It is widely known that alcohol consumption adversely affects human health, particularly in the immature developing brains of adolescents and young adults, which may also have a long-lasting impact on executive functioning. The present study investigated the neural activity of 28 young adults from the Ottawa Prenatal Prospective Study (OPPS) using functional magnetic resonance imaging (fMRI). The purpose of this study was to discover the impact of regular low-level alcohol consumption on response inhibition as the participants performed a Go/No-Go task...
April 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28434481/is-there-a-role-for-lifestyle-changes-in-cardiovascular-prevention-what-when-and-how
#15
Lluís Masana, Emilio Ros, Isabella Sudano, Denis Angoulvant
BACKGROUND AND AIMS: Lifestyle has been found to play an important role in the prevention of cardiovascular disease (CVD). There is evidence to suggest that if lifestyle factors are modified successfully, the relative risk of CVD can be reduced. Risk factors for CVD such as high blood pressure, diabetes mellitus and dyslipidaemias can be modified by lifestyle changes. The main aim of this article is to provide best practice approaches and support for healthcare professionals on the role of lifestyle changes in the prevention of CVD...
April 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/28434201/how-much-alcohol-is-consumed-outside-of-the-lifetime-risk-guidelines-in-australia
#16
Sarah Callinan, Michael Livingston, Robin Room, Paul M Dietze
INTRODUCTION AND AIMS: This study aims to estimate the prevalence of long-term risky drinking within the Australian population and the proportion of standard drinks that is consumed outside of the long-term risk (LTR) guidelines of two Australian standard drinks (ASD) per day. DESIGN AND METHODS: Recruited by phone, 2020 Australian adults with an oversampling of risky drinkers were asked detailed questions about how much alcohol they consumed at a range of locations in 2013...
April 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28433466/orosensory-responsiveness-and-alcohol-behaviour
#17
Margaret Thibodeau, Martha Bajec, Gary Pickering
Consumption of alcoholic beverages is widespread through much of the world, and significantly impacts human health and well-being. We sought to determine the contribution of orosensation ('taste') to several alcohol intake measures by examining general responsiveness to taste and somatosensory stimuli in a convenience sample of 435 adults recruited from six cohorts. Each cohort was divided into quantiles based on their responsiveness to sweet, sour, bitter, salty, umami, metallic, and astringent stimuli, and the resulting quantiles pooled for analysis (Kruskal-Wallis ANOVA)...
April 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28433461/severely-impaired-adult-brain-neurogenesis-in-cyclin-d2-knock-out-mice-produces-very-limited-phenotypic-changes
#18
REVIEW
Robert K Filipkowski, Leszek Kaczmarek
The discovery of new neurons being produced in the brains of adult mammals (adult brain neurogenesis) began a quest to determine the function(s) of these cells. Major hypotheses in the field have assumed that these neurons play pivotal role, in particular, in learning and memory phenomena, mood control, and epileptogenesis. In our studies summarized herein, we used cyclin D2 knockout (KO) mice, as we have shown that cyclin D2 is the key factor in adult brain neurogenesis and thus its lack produces profound impairment of the process...
April 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28433423/prefrontal-cortex-expression-of-chromatin-modifier-genes-in-male-wsp-and-wsr-mice-changes-across-ethanol-dependence-withdrawal-and-abstinence
#19
Joel G Hashimoto, David P Gavin, Kristine M Wiren, John C Crabbe, Marina Guizzetti
Alcohol-use disorder (AUD) is a relapsing disorder associated with excessive ethanol consumption. Recent studies support the involvement of epigenetic mechanisms in the development of AUD. Studies carried out so far have focused on a few specific epigenetic modifications. The goal of this project was to investigate gene expression changes of epigenetic regulators that mediate a broad array of chromatin modifications after chronic alcohol exposure, chronic alcohol exposure followed by 8 h withdrawal, and chronic alcohol exposure followed by 21 days of abstinence in Withdrawal-Resistant (WSR) and Withdrawal Seizure-Prone (WSP) selected mouse lines...
March 14, 2017: Alcohol
https://www.readbyqxmd.com/read/28432604/phosphate-imbalance-in-patients-with-heart-failure
#20
REVIEW
E C Christopoulou, T D Filippatos, E Megapanou, M S Elisaf, G Liamis
Patients with heart failure often exhibit electrolyte abnormalities, such as hyponatremia or hypokalemia/hyperkalemia. Although not as common as the other electrolyte disturbances observed in patients with heart failure, phosphate imbalance is also of high importance in this population. The aim of this review is to present the mechanisms of low or high phosphate serum levels in patients with heart failure and its role in the pathogenesis and progression of heart dysfunction. Hypophosphatemia in patients with heart failure may be the result of co-existing electrolyte and acid-base abnormalities, pharmacological treatments, decreased intestinal absorption or secondary to sympathetic nervous system activation and co-morbidities, such as diabetes mellitus or heavy alcohol consumption...
April 22, 2017: Heart Failure Reviews
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