keyword
https://read.qxmd.com/read/38537007/independent-predictors-for-non-alcoholic-fatty-liver-disease-in-patients-with-treatment-na%C3%A3-ve-chronic-hepatitis-b
#1
JOURNAL ARTICLE
Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Osman Faruk Bayramlar, Burcu Atasoy Bozan, Cigdem Yucel, Betul Copur, Kadir Gorkem Guclu, Mustafa Yıldırım, Gonul Sengöz, Filiz Pehlivanoglu
OBJECTIVE: There are limited data on non-alcoholic fatty liver disease in chronic hepatitis B virus infection. We aimed to determine the predictors for non-alcoholic fatty liver disease in patients with treatment-naïve chronic hepatitis B virus infection. METHODS: All consecutive treatment-naïve patients with chronic hepatitis B virus infection at the Haseki Training and Research Hospital between October 1, 2021, and September 31, 2022, were retrospectively enrolled...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536961/health-risk-behaviours-co-occur-among-adults-with-tooth-loss
#2
JOURNAL ARTICLE
Saeed G Alzahrani, Kavita Rijhwani, Wael Sabbah
INTRODUCTION: Health-risk behaviours tend to co-occur among the same sectors of the population. The aim of this study is to examine the association between an aggregate of multiple health-risk behaviours and tooth loss among American Adults. METHODS: We used data from the Behavioural Risk Factor Surveillance System (BRFSS) 2022, a nationally representative survey of non-institutionalized American. We included participants aged 18 years and older. An aggregate variable of health-risk behaviours which included smoking, heavy alcohol consumption, lack of physical activities, overweight/obesity, infrequent dental visits and infrequent medical check-up was created...
March 27, 2024: International Journal of Dental Hygiene
https://read.qxmd.com/read/38536228/digital-alcohol-interventions-could-be-part-of-the-societal-response-to-harmful-consumption-but-we-know-little-about-their-long-term-costs-and-health-outcomes
#3
JOURNAL ARTICLE
Katarina Ulfsdotter Gunnarsson, Martin Henriksson, Marcus Bendtsen
Alcohol consumption causes both physical and psychological harm and is a leading risk factor for noncommunicable diseases. Digital alcohol interventions have been found to support those looking for help by giving them tools for change. However, whether digital interventions can help tackle the long-term societal consequences of harmful alcohol consumption in a cost-effective manner has not been adequately evaluated. In this Viewpoint, we propose that studies of digital alcohol interventions rarely evaluate the consequences of wider dissemination of the intervention under study, and that when they do, they do not take advantage of modeling techniques that allow for appropriately studying consequences over a longer time horizon than the study period when the intervention is tested...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38536225/effectiveness-of-the-minder-mobile-mental-health-and-substance-use-intervention-for-university-students-randomized-controlled-trial
#4
JOURNAL ARTICLE
Melissa Vereschagin, Angel Y Wang, Chris G Richardson, Hui Xie, Richard J Munthali, Kristen L Hudec, Calista Leung, Katharine D Wojcik, Lonna Munro, Priyanka Halli, Ronald C Kessler, Daniel V Vigo
BACKGROUND: University attendance represents a transition period for students that often coincides with the emergence of mental health and substance use challenges. Digital interventions have been identified as a promising means of supporting students due to their scalability, adaptability, and acceptability. Minder is a mental health and substance use mobile app that was codeveloped with university students. OBJECTIVE: This study aims to examine the effectiveness of the Minder mobile app in improving mental health and substance use outcomes in a general population of university students...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38534155/long-term-risks-for-cirrhosis-and-hepatocellular-carcinoma-across-steatotic-liver-disease-subtypes
#5
JOURNAL ARTICLE
Yi-Ting Chen, Tzu-I Chen, Tsai-Hsuan Yang, Szu-Ching Yin, Sheng-Nan Lu, Xia-Rong Liu, Yun-Zheng Gao, Chih-Jo Lin, Chia-Wei Huang, Jee-Fu Huang, Ming-Lun Yeh, Chung-Feng Huang, Chia-Yen Dai, Wan-Long Chuang, Hwai-I Yang, Ming-Lung Yu, Mei-Hsuan Lee
INTRODUCTION: The prospective study aimed to investigate the long-term associated risks of cirrhosis and hepatocellular carcinoma (HCC) across various subtypes of steatotic liver disease (SLD). METHODS: We enrolled 332,175 adults who participated in a health screening program between 1997 and 2013. Participants were categorized into various subtypes, including metabolic dysfunction-associated steatotic liver disease (MASLD), MASLD with excessive alcohol consumption (MetALD), and alcohol-related liver disease (ALD), based on ultrasonography findings, alcohol consumption patterns, and cardiometabolic risk factors...
March 27, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38533996/alcohol-related-care-among-veterans-with-unhealthy-alcohol-use-the-role-of-long-term-opioid-therapy-receipt
#6
JOURNAL ARTICLE
Paul J Joudrey, Melinda Wang, Eric DeRycke, Emily C Williams, Eva Jennifer Edelman
OBJECTIVES: Long-term opioid therapy (LTOT) is potentially dangerous among patients with unhealthy alcohol use because of possible adverse interactions. We examined receipt of alcohol-related care among patients with unhealthy alcohol use receiving LTOT and without opioid receipt. METHODS: We use data collected from 2009 to 2017 in the Women Veterans Cohort Study, a national cohort of Veterans engaged in Veterans Health Administration care. We included patients who screened positive for unhealthy alcohol use (score ≥5) using the Alcohol Use Disorder Identification Consumption questionnaire...
March 27, 2024: Journal of Addiction Medicine
https://read.qxmd.com/read/38533958/associations-of-alcohol-consumption-with-left-atrial-morphology-and-function-in-a-population-at-high-cardiovascular-risk
#7
JOURNAL ARTICLE
Aniqa B Alam, Estefania Toledo-Atucha, Dora Romaguera, Angel M Alonso-Gómez, Miguel A Martínez-Gonzalez, Lucas Tojal-Sierra, Marta Noris Mora, Caterina Mas-Llado, Linzi Li, Ines Gonzalez-Casanova, Jordi Salas-Salvadó, Montserrat Fitó, Alvaro Alonso
BACKGROUND: Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention. METHODS AND RESULTS: We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533737/combined-effects-of-smoking-and-alcohol-consumption-on-the-risk-of-liver-cancer-according-to-metabolic-syndrome-a-nested-case-control-study-in-south-korea
#8
JOURNAL ARTICLE
Thi Tra Bui, Eunjung Park, Hee-Yeon Kang, Jin-Kyoung Oh
Tobacco and alcohol may interact to increase the risk of liver cancer, which might be modified by other risk factors. Their combined effects in the context of metabolic syndrome (MetS) remain unclear. Given the increasing prevalence of MetS, this nested case-control study was conducted to evaluate the combined effects of smoking and alcohol consumption on liver cancer risk with stratification by MetS. We included 15,352 liver cancer patients and 92,112 matched controls who attended the nationwide general health examination during 2009-2019, using a customized database (N = 5,545,835) from the Korean National Health Insurance Service...
March 27, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38533342/co-occurrence-of-and-factors-associated-with-health-risk-behaviors-among-adolescents-a-multi-center-study-in-sub-saharan-africa-china-and-india
#9
JOURNAL ARTICLE
Xuan Li, Yadeta Dessie, Mary Mwanyika-Sando, Nega Assefa, Ourohiré Millogo, Adom Manu, Angela Chukwu, Justine Bukenya, Rutuja Patil, Siyu Zou, Hanxiyue Zhang, Lina Nurhussien, Amani Tinkasimile, Till Bärnighausen, Sachin Shinde, Wafaie W Fawzi, Kun Tang
BACKGROUND: Despite lifelong and detrimental effects, the co-occurrence of health risk behaviors (HRBs) during adolescence remains understudied in low- and middle-income countries. This study examines the co-occurrence of HRBs and its correlates among adolescents in sub-Saharan Africa, China, and India. METHODS: A multi-country cross-sectional study was conducted in 2021-2022, involving 9697 adolescents (aged 10-19 years) from eight countries, namely Burkina Faso, China, Ethiopia, India, Ghana, Nigeria, Tanzania, and Uganda...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38533310/prevalence-of-hypertension-and-its-associated-factors-among-adults-living-with-hiv-on-antiretroviral-treatment-in-selected-public-hospitals-in-addis-ababa-ethiopia
#10
JOURNAL ARTICLE
Meskelu Haile, Tamiru Degelo, Takele Menna Adilo, Fatimetu Mohammed Adem, Bedasa Gidisa
INTRODUCTION: Hypertension significantly increases the risk of heart, brain, and renal diseases and is one of the leading causes of death and disease worldwide. It is a major comorbidity among HIV-positive people. There have been limited attempts to detect hypertension and its related variables in patients receiving antiretroviral treatment, notably in Addis Ababa, Ethiopia. The current study intended to examine the incidence of hypertension and related variables among adults aged 18 and over living with HIV on ART at selected public referral hospitals in Addis Ababa, Ethiopia...
2024: HIV/AIDS: Research and Palliative Care
https://read.qxmd.com/read/38532435/liver-stiffness-and-associated-risk-factors-among-people-with-a-history-of-injecting-drugs-a-prospective-cohort-study
#11
JOURNAL ARTICLE
Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Tesfaye Madebo, Håvard Midgard, Olav Dalgard, Rafael Alexander Leiva, Lars T Fadnes
BACKGROUND: Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population. Chronic liver diseases are a substantial cause of this. Screening strategies based on liver stiffness measurements (LSM) may facilitate early detection, timely intervention, and treatment of liver disease. This study aims to investigate the extent of chronic liver disease measured with transient elastography and the association between LSM and various risk factors, including substance use patterns, hepatitis C virus (HCV) infection, alcohol use, body mass index, age, type 2 diabetes mellitus, and high-density lipoprotein (HDL) cholesterol among people with OUD or with SUD who inject substances...
March 26, 2024: Substance Abuse Treatment, Prevention, and Policy
https://read.qxmd.com/read/38532309/contribution-of-nutritional-lifestyle-and-metabolic-risk-factors-to-parkinson-s-disease
#12
JOURNAL ARTICLE
Nicola Veronese, Andrea Nova, Teresa Fazia, Emilia Riggi, Lin Yang, Laura Piccio, Bo-Huei Huang, Matthew Ahmadi, Mario Barbagallo, Maria Notarnicola, Gianluigi Giannelli, Giovanni De Pergola, Emmanuel Stamatakis, Emanuele Cereda, Luisa Bernardinelli, Luigi Fontana
BACKGROUND: Modifiable risk factors for Parkinson's disease (PD) are poorly known. OBJECTIVES: The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD. METHODS: In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38532273/men-s-experiences-of-a-personalised-appearance-based-facial-morphing-safer-drinking-intervention
#13
JOURNAL ARTICLE
Ian R Burgess, Alison Owen, Keira Scholtens, Sarah Grogan
Risky alcohol consumption behaviours remain commonplace, representing a major threat to health and safety, and are especially evidenced by young university students. Consequently, new interventions targeting this high-risk group are required. The current study investigated young male university students' experiences of a personalised, appearance-based, facial morphing, safer drinking intervention. Twenty-five male student participants were recruited, aged 18-34 years. Inductive thematic analysis of data gathered whilst participants were immersed in the intervention, and thereby exposed to alcohol-aged images of their own faces, produced four primary themes: alcohol as a threat to appearance and health, motivations to protect appearance, motivational aspects of the intervention, and proposed improvements and applications...
March 26, 2024: Journal of Health Psychology
https://read.qxmd.com/read/38532169/resection-status-and-margin-control-in-intraoperative-frozen-sectioning-analysis-of-oral-squamous-cell-carcinoma
#14
JOURNAL ARTICLE
Felix Neumann, Xenia Straub, Friedrich Mrosk, Kerstin Rubarth, Johanna Wolfsberg, Iris Piwonski, Christian Doll, Jan Voss, Max Heiland, Kilian Kreutzer, Steffen Koerdt
PURPOSE: Intraoperative frozen section analysis (IFSA) is a well-established procedure for determining the intraoperative soft tissue resection status in patients with oral squamous cell carcinoma (OSCC). Margin status is a major predictor of the patient´s outcome, histologically free margins of ≥ 5 mm are demanded. This study evaluates the accuracy of IFSA, the impact of margin status and the impact of intraoperative margin revision on disease-free survival (DFS) and overall survival (OS)...
March 27, 2024: Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38532019/serial-mediating-effects-of-childhood-trauma-and-conduct-behaviors-on-the-impact-of-family-history-among-patients-with-alcohol-use-disorder
#15
JOURNAL ARTICLE
Min Jeong Han, Shin Tae Kim, Chun Il Park, Syung Shick Hwang, Hae Won Kim, Jee In Kang, Se Joo Kim
Family history (FH) of alcoholism increases the risk of alcohol use disorder (AUD); however, the contribution of childhood trauma (CT) in this respect remains unclear. This study investigated the relationship between FH and AUD-related clinical characteristics (social onset, antisocial tendency, and severity of problematic alcohol consumption) through the mediating effects of childhood trauma (CT) and conduct behaviors (CB) in a Korean male population with AUD. A total of 304 patients hospitalized for AUD at 16 psychiatric hospitals completed standardized questionnaires, including self-rated scales...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531832/molecular-mechanisms-involved-in-alcohol-craving-irf3-and-endoplasmic-reticulum-stress-a-multi-omics-study
#16
JOURNAL ARTICLE
Ming-Fen Ho, Cheng Zhang, Irene Moon, Mustafa Tuncturk, Brandon J Coombes, Joanna Biernacka, Michelle Skime, Tyler S Oesterle, Victor M Karpyak, Hu Li, Richard Weinshilboum
Alcohol use disorder (AUD) is the most prevalent substance use disorder worldwide. Acamprosate and naltrexone are anti-craving drugs used in AUD pharmacotherapy. However, molecular mechanisms underlying their anti-craving effect remain unclear. This study utilized a patient-derived induced pluripotent stem cell (iPSC)-based model system and anti-craving drugs that are used to treat AUD as "molecular probes" to identify possible mechanisms associated with alcohol craving. We examined the pathophysiology of craving and anti-craving drugs by performing functional genomics studies using iPSC-derived astrocytes and next-generation sequencing...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#17
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
https://read.qxmd.com/read/38528612/can-a-health-warning-label-diminish-the-persuasive-effects-of-health-oriented-nutrition-advertising-on-ready-to-drink-alcohol-product-packaging-a-randomized-experiment
#18
JOURNAL ARTICLE
Erin Hobin, Justin Thielman, Samantha M Forbes, Theresa Poon, Ariane Bélanger-Gravel, Élisabeth Demers-Potvin, Ashleigh Haynes, Ye Li, Manon Niquette, Catherine Paradis, Véronique Provencher, Brendan T Smith, Samantha Wells, Amanda Atkinson, Lana Vanderlee
BACKGROUND AND AIMS: A health warning label (HWL) cautioning about the link between alcohol and cancer may be able to communicate alcohol risks to consumers and potentially counter health-oriented nutrition advertising on ready-to-drink alcoholic beverages. This study aimed to examine the independent and combined effects of nutrient content claims (e.g. 0 g sugar) and a HWL on perceived product characteristics and intentions to consume, and whether these effects differed by gender and age...
March 25, 2024: Addiction
https://read.qxmd.com/read/38528283/lifestyle-changes-after-cancer-treatment-in-patients-and-their-partners-a-qualitative-study
#19
JOURNAL ARTICLE
Marrit Annika Tuinman, Janine Nuver, Anke de Boer, Anne Looijmans, Mariët Hagedoorn
PURPOSE: Oncologists nowadays promote healthy lifestyle choices more often, focusing on diet, physical activity, smoking, alcohol consumption, and sleep, but the question is whether this is enough to establish actual change. As patients will have to achieve a healthy lifestyle at home in daily life, it is important to understand barriers and facilitators for lifestyle change for both patients and their partners. METHODS: A qualitative interview study was done among patients who received chemotherapy for testicular (n = 10) or breast cancer (n = 7) and their partners (n = 17)...
March 26, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38527457/biologically-informed-polygenic-scores-for-brain-insulin-receptor-network-are-associated-with-cardiometabolic-risk-markers-and-diabetes-in-women
#20
JOURNAL ARTICLE
Jannica S Selenius, Patricia P Silveira, Mikaela von Bonsdorff, Jari Lahti, Hannu Koistinen, Riitta Koistinen, Markku Seppälä, Johan G Eriksson, Niko S Wasenius
BACKGROUND: To investigate associations between variations in the co-expression-based brain insulin receptor polygenic score and cardiometabolic risk factors and diabetes mellitus. METHODS: This cross-sectional study included 1,573 participants from the Helsinki Birth Cohort Study. Biologically informed expression-based polygenic risk scores for the insulin receptor gene network were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions...
March 25, 2024: Diabetes & Metabolism Journal
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