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Sjogren's syndrome;ultrasound

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https://www.readbyqxmd.com/read/28212920/neonatal-lupus-follow-up-in-infants-with-anti-ssa-ro-antibodies-and-review-of-the-literature
#1
REVIEW
Antonio Alberto Zuppa, Riccardo Riccardi, Simonetta Frezza, Francesca Gallini, Rita Maria Paola Luciano, Giovanni Alighieri, Costantino Romagnoli, Sara De Carolis
Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clinical manifestations: complete congenital heart block (CCHB) and cutaneous lupus are the most common, while hepatobiliary disease, hematological manifestations and central nervous system involvement may occur...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28138914/obstetric-and-perinatal-outcome-in-anti-ro-ssa-positive-pregnant-women-a-prospective-cohort-study
#2
Nuria Martínez-Sánchez, Sergio Pérez-Pinto, Ángel Robles-Marhuenda, Francisco Arnalich-Fernández, María Martín Cameán, Edurne Hueso Zalvide, Jose Luis Bartha
: Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). The aim of this study was to compare the rate of maternal and fetal complications between a series of anti-Ro/SS-A positive pregnant women prospectively followed...
January 30, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28103850/acupuncture-for-primary-sj%C3%A3-gren-syndrome-pss-on-symptomatic-improvements-study-protocol-for-a-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Quan Jiang, Huadong Zhang, Ran Pang, Jinzhou Chen, Zhishun Liu, Xinyao Zhou
BACKGROUND: Currently, feasible medical treatments are hitherto not satisfying to relieve pSS symptoms, which concerns numbers of clinical doctors. Acupuncture seems to be an alternative to treat pSS and conduces to good symptomatic results. However further research is necessary. This trial is to investigate the efficacy of acupuncture on improving the key symptoms of pSS, which are dryness, pain and fatigue (DPF). METHODS & DESIGN: The study is designed as a randomized controlled trial of two arms with a single centre...
January 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27941210/-contemporary-diagnostics-of-the-primary-sj%C3%A3-gren-s-syndrome
#4
Jolanta Parada-Turska
Primary Sjögren's syndrome is one of the most common systemic autoimmune disorders, whose diagnosis is very often delayed. In most cases it is a mild disease with symptoms such as dryness and musculoskeletal pain and fatigue but 20-40% of patients suffer from severe systemic manifestations. Extraglandular manifestations can be the first sign of the disease, therefore it is very important to diagnose them as early as possible. Classification criteria established by the American-European Consensus Group (AECG) have been applied in primary Sjögren's syndrome diagnosis since 2002...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27931961/imaging-of-connective-tissue-diseases-beyond-visceral-organ-imaging
#5
REVIEW
Maurizio Cutolo, Nemanja Damjanov, Barbara Ruaro, Ana Zekovic, Vanessa Smith
Connective tissues diseases (CTDs) can also be diagnosed early by "external" and safe imaging methods beyond the visceral organ analysis. This study aims to explore various imaging techniques used in diagnosing CTDs. Skin impairment in systemic sclerosis (SSc) may be recognized and studied by the modified Rodnan skin score (mRSS), which has some drawbacks, whereas high-frequency ultrasound (US) seems advantageous for the early identification of skin involvement. Salivary gland involvement in Sjögren syndrome (SS) can be assessed using standard tests such as unstimulated salivary flow test, salivary gland scintigraphy or contrast sialography...
August 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27900604/assessment-of-interstitial-lung-disease-in-sj%C3%A3-gren-s-syndrome-by-lung-ultrasound-a-pilot-study-of-correlation-with-high-resolution-chest-tomography
#6
Pablo Guisado Vasco, Gonzalo de Luna Cardenal, Isabel Martín Garrido, José Manuel Luque Pinilla, Guadalupe Fraile Rodríguez, Juan José Nava Mateo, Daniel Carnevalli Ruiz
The background of this study is to assess the accuracy of lung ultrasound (LUS) to diagnose interstitial lung disease (ILD) in Sjögren's syndrome (Sjs), in patients who have any alterations in pulmonary function tests (PFT) or respiratory symptoms. LUS was correlated with chest tomography (hrCT), considering it as the imaging gold standard technique to diagnose ILD. This is a pilot, multicenter, cross-sectional, and consecutive-case study. The inclusion criteria are ≥18 years old, Signs and symptoms: according to ACEG 2002 criteria, respiratory symptoms (dyspnea, cough), or any alterations in PFR...
November 29, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27749218/serum-calprotectin-is-a-biomarker-of-carotid-atherosclerosis-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#7
Gabriela M Balarini, Eliana Zandonade, Leandro Tanure, Gilda A Ferreira, Wildner M Sardenberg, Érica V Serrano, Cleia C Dias, Túlio P Navarro, Hilde H Nordal, Piotr M Mydel, Johan G Brun, Karl A Brokstad, Eva Gerdts, Roland Jonsson, Valéria Valim
OBJECTIVES: We aimed to identify the association of carotid atherosclerosis with the traditional risk factors, disease features, cytokine profile, and calprotectin in patients with primary Sjögren's syndrome (pSS). METHODS: 63 primary pSS patients and 63 age- and sex-matched healthy controls underwent carotid ultrasound, clinical and laboratory examination. The presence of carotid plaques was taken as carotid atherosclerosis. The covariates of carotid atherosclerosis were identified in univariate and multivariate regressions...
November 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27576331/how-is-the-ultrasound-in-rheumatology-used-implemented-and-applied-in-latin-american-centers-results-from-a-multicenter-study
#8
Marwin Gutierrez, Cristina Hernandez-Diaz, Lucio Ventura-Rios, Lina María Saldarriaga-Rivera, Santiago Ruta, Magaly Alva, Claudia Mora -Trujillo, Wilkerson Pérez, Henry Terrazas, Rodolfo Del Carmen Arape Toyo, Maritza Quintero, Carla Solano, Oscar Sedano Santiago, Janet Grisel Huamán Sotomayor, Cesar Cefferino, Guillermo E Py, Marcelo J Audisio, Walter Javier Spindler, Horacio Berman, Carla Airoldi, Rómulo Wong, Ana Laura Álvarez Del Castillo Araujo, Mario E Díaz, Carmen Cerón Villaquiran, Rubén Darío Mantilla, José Alexandre Mendonça, Inês Guimarães da Silveira, Aline Defaveri do Prado, Melissa Cláudia Bisi, Violeta Rosario, Jeannette Medrano-Sánchez, Roberto Muñoz-Louis, Ana Cecilia Lozada-Navarro, Araceli Bernal, Maribel Lozano, Carlos Pineda
This study aimed to perform an overview of how ultrasound (US) is being used, implemented, and applied in rheumatologic centers in Latin America (LA). A retrospective, multicenter 1-year experience study was undertaken. Eighteen centers from eight countries were involved. The following information were collected: demographic data, indication to perform an US examination, physician that required the examination, and the anatomical region required for the examination. A total of 7167 patients underwent an US examination...
December 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27528574/multiobserver-reliability-of-ultrasound-assessment-of-salivary-glands-in-patients-with-established-primary-sj%C3%A3-gren-syndrome
#9
Nemanja Damjanov, Vera Milic, Juan Carlos Nieto-González, Iustina Janta, Lina Martínez-Estupiñan, Belén Serrano, Carmen Mata, María Montoro, Denisa Stanciu, Jelena Marinković-Erić, Francisco Javier López-Longo, Luis Carreño, Esperanza Naredo
OBJECTIVE: To evaluate the multiobserver reliability of salivary gland ultrasonography (SGUS) for scoring greyscale (GS) parenchymal inhomogeneity and parenchymal color Doppler (CD) signal in patients with established primary Sjögren syndrome (pSS). METHODS: The study comprised 2 multiobserver reliability assessments in patients with pSS in 2 European centers. The first reliability exercise was performed on 24 patients with pSS and 8 controls who were independently evaluated with GS and CD US by 5 observers at the Institute of Rheumatology, Belgrade, Serbia...
October 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27446602/standards-for-the-assessment-of-salivary-glands-an-update
#10
REVIEW
Piotr Zajkowski, Aleksandra Ochal-Choińska
The paper is an update of 2011 Standards for Ultrasound Assessment of Salivary Glands, which were developed by the Polish Ultrasound Society. We have described current ultrasound technical requirements, assessment and measurement techniques as well as guidelines for ultrasound description. We have also discussed an ultrasound image of normal salivary glands as well as the most important pathologies, such as inflammation, sialosis, collagenosis, injuries and proliferative processes, with particular emphasis on lesions indicating high risk of malignancy...
June 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/26660860/ultrasound-of-the-salivary-glands-is-a-strong-predictor-of-labial-gland-biopsy-histopathology-in-patients-with-sicca-symptoms
#11
Elisa Astorri, Nurhan Sutcliffe, Polly S Richards, Krishna Suchak, Costantino Pitzalis, Michele Bombardieri, Anwar R Tappuni
BACKGROUND: The international classification criteria for Sjögren's syndrome necessitate the presence of either extractable nuclear antibody or a characteristic focal inflammatory infiltrate in a minor salivary gland. Thus, patients who are extractable nuclear antibody-negative will need to have a labial salivary gland biopsy, which is an invasive procedure associated with morbidity. The aim of this study was to evaluate the viability of ultrasound imaging of the major salivary glands as a predictor of the histology to explore whether ultrasound can help in stratifying Sjögren's patients and reduce the need for biopsy...
July 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/26626630/focal-myositis-presenting-as-pseudothrombophlebitis-of-the-arm
#12
REVIEW
Susana Roverano, Alberto Ortiz, Sergio Paira
We described a 21-year-old woman with a diagnosis of Sjögren syndrome that came for consultation with a localized mass over her left arm of fast growth. Lab results were normal; a Doppler ultrasound showed the presence of partial thrombosis in the left axillary vein; a magnetic resonance imaging showed edema on the biceps muscle and the biopsy of the mass disclosed the presence of severe lymphocyte infiltrate within the connective tissue and scarce muscle fibers. Immunostaining showed positive results for antígeno comun leucocitario in spanish (leukocyte common antigen) (ACL) and CD3...
April 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/26608250/-clinical-usefulness-of-salivary-gland-ultrasonography-in-sj%C3%A3-gren-s-syndrome-where-are-we-now
#13
REVIEW
D Cornec, V Devauchelle-Pensec, A Saraux, S Jousse-Joulin
Salivary gland ultrasonography is a simple, noninvasive and inexpensive procedure, which provides valuable information for the diagnosis of primary Sjögren's syndrome (pSS). The main sonographic characteristic of the major salivary glands (parotid and submandibular) in pSS patients is the heterogeneity of the parenchyma, with the appearance of hypoechoic areas. Numerous studies published over the past 20 years report a sensitivity of 70% and a specificity of more than 90% for the diagnosis of pSS. Before the widespread use of this procedure in daily practice and its integration into classification criteria of the disease, it has yet to be validated in terms of reproducibility and a consensus score should be established...
March 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/26445930/low-intensity-pulsed-ultrasound-rescues-insufficient-salivary-secretion-in-autoimmune-sialadenitis
#14
Minami Sato, Shingo Kuroda, Karima Qurnia Mansjur, Ganzorig Khaliunaa, Kumiko Nagata, Shinya Horiuchi, Toshihiro Inubushi, Yoshiko Yamamura, Masayuki Azuma, Eiji Tanaka
INTRODUCTION: Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one of the most common symptoms in Sjögren syndrome (SS). It is caused by a decrease in the quantity or quality of saliva. The successful treatment of xerostomia is still difficult to achieve and often unsatisfactory. The aim of this study is to clarify the therapeutic effects of LIPUS on xerostomia in SS...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26374590/mediastinal-sarcoidosis-diagnosed-by-endobronchial-ultrasound-in-a-patient-with-sj%C3%A3-gren-s-syndrome
#15
Augusto Carbonari, Marco Camunha, Fabio Marioni, Mauro Saieg, Lucio Rossini
No abstract text is available yet for this article.
July 2015: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/26368934/which-and-how-many-patients-should-be-included-in-randomised-controlled-trials-to-demonstrate-the-efficacy-of-biologics-in-primary-sj%C3%A3-gren-s-syndrome
#16
Valérie Devauchelle-Pensec, Jacques-Eric Gottenberg, Sandrine Jousse-Joulin, Jean-Marie Berthelot, Aleth Perdriger, Eric Hachulla, Pierre Yves Hatron, Xavier Puechal, Véronique Le Guern, Jean Sibilia, Laurent Chiche, Vincent Goeb, Olivier Vittecoq, Claire Larroche, Anne Laure Fauchais, Gilles Hayem, Jacques Morel, Charles Zarnitsky, Jean Jacques Dubost, Philippe Dieudé, Jacques Olivier Pers, Divi Cornec, Raphaele Seror, Xavier Mariette, Emmanuel Nowak, Alain Saraux
OBJECTIVE: The goal of this study was to determine how the choice of the primary endpoint influenced sample size estimates in randomised controlled trials (RCTs) of treatments for primary Sjögren's syndrome (pSS). METHODS: We reviewed all studies evaluating biotechnological therapies in pSS to identify their inclusion criteria and primary endpoints. Then, in a large cohort (ASSESS), we determined the proportion of patients who would be included in RCTs using various inclusion criteria sets...
2015: PloS One
https://www.readbyqxmd.com/read/26245278/il-17-sequestration-via-salivary-gland-gene-therapy-in-a-mouse-model-of-sjogren-s-syndrome-suppresses-disease-associated-expression-of-the-putative-autoantigen-klk1b22
#17
Changgong Wu, Zhimin Wang, Lee Zourelias, Hiteshi Thakker, Michael J Passineau
INTRODUCTION: IL-17 has a putative role in the pathophysiology of Sjogren's syndrome (SS) and has been shown to be upregulated in the salivary glands of affected individuals. Sequestration of IL-17 with Adenoviral-mediated gene therapy has previously shown a benefit upon the SS-like phenotype in the Aec1/Aec2 mouse model. We sought to understand the proteomic consequences of IL-17 sequestration in the salivary gland of this mouse model as a means of illuminating the role of IL-17 in SS-like disease...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26149284/advances-in-salivary-gland-gene-therapy-oral-and-systemic-implications
#18
REVIEW
Bruce J Baum, Ilias Alevizos, John A Chiorini, Ana P Cotrim, Changyu Zheng
INTRODUCTION: Much research demonstrates the feasibility and efficacy of gene transfer to salivary glands. Recently, the first clinical trial targeting a salivary gland was completed, yielding positive safety and efficacy results. AREAS COVERED: There are two major disorders affecting salivary glands: radiation damage following treatment for head and neck cancers and Sjögren's syndrome (SS). Salivary gland gene transfer has also been employed in preclinical studies using transgenic secretory proteins for exocrine (upper gastrointestinal tract) and endocrine (systemic) applications...
2015: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/26022533/salivary-gland-ultrasonography-a-highly-specific-tool-for-the-early-diagnosis-of-primary-sj%C3%A3-gren-s-syndrome
#19
COMPARATIVE STUDY
Chiara Baldini, Nicoletta Luciano, Gaia Tarantini, Rachele Pascale, Francesca Sernissi, Marta Mosca, Davide Caramella, Stefano Bombardieri
INTRODUCTION: Recently, a great interest has arisen for salivary gland ultrasonography (SGUS) as a valuable tool for the assessment of major salivary gland involvement in primary Sjögren's syndrome (pSS. The aims of this study were to test the accuracy of SGUS for the early detection of pSSand to compare the diagnostic performance of SGUS with minor salivary gland biopsy (MSGB) and unstimulated salivary flow (USFR) in this context. METHOD: Patients with suspected pSS and symptoms duration of ≤5 years were consecutively enrolled in this study...
May 28, 2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25988616/diagnostic-properties-of-ultrasound-of-major-salivary-glands-in-sj%C3%A3-gren-s-syndrome-a-meta-analysis
#20
REVIEW
K Delli, P U Dijkstra, A J Stel, H Bootsma, A Vissink, F K L Spijkervet
OBJECTIVE: To perform a systematic review and meta-analysis on studies examining the properties of ultrasonography of major salivary glands for diagnosing Sjögren's syndrome. MATERIALS AND METHODS: We searched for the literature on eight databases. The quality of included articles was assessed with the QUADAS-2 tool. Publication bias, pooled sensitivity, specificity, diagnostic odds ratio, and 95% confidence intervals (95%CI) were calculated. Meta-regression analysis was performed...
September 2015: Oral Diseases
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