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Rheumatoid arthritis;synovial

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https://www.readbyqxmd.com/read/28086960/the-relationship-between-synovitis-quantified-by-an-ultrasound-7-joint-inflammation-score-and-physical-disability-in-rheumatoid-arthritis-a-cohort-study
#1
Jakub Závada, Petra Hánová, Jana Hurňáková, Lenka Szczuková, Michal Uher, Šárka Forejtová, Martin Klein, Herman Mann, Marta Olejárová, Olga Růžičková, Olga Šléglová, Karel Hejduk, Karel Pavelka
BACKGROUND: Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It is unknown, whether the extent of synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for physical functioning. To answer this question we investigated the longitudinal relationship between physical function assessed by the health assessment questionnaire (HAQ) and the German 7-joint ultrasound score (US7S) in a prospective cohort of patients with RA...
January 13, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28079986/establishment-of-an-in-vitro-3-d-model-for-cartilage-damage-in-rheumatoid-arthritis-ra
#2
Yvonne Peck, Li Ting Leom, Pei Fen Patricia Low, Dong-An Wang
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to progressive joint destruction. To further understand the process of rheumatoid cartilage damage, an in vitro model consisting of an interactive tri-culture of synovial fibroblasts (SFs), LPS-stimulated macrophages and a primary chondrocyte-based tissue engineered construct was established. The tissue engineered construct has a similar composition to human cartilage, which are rich in collagen type II and proteoglycans. Data generated from this model revealed that healthy chondrocytes were activated in the presence of SFs and macrophages...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28079506/response-of-human-rheumatoid-arthritis-osteoblasts-and-osteoclasts-to-adiponectin
#3
Grit Krumbholz, Susann Junker, Florian M P Meier, Markus Rickert, Jürgen Steinmeyer, Stefan Rehart, Uwe Lange, Klaus W Frommer, Georg Schett, Ulf Müller-Ladner, Elena Neumann
OBJECTIVES: Adiponectin is an effector molecule in the pathophysiology of rheumatoid arthritis, e.g. by inducing cytokines and matrix degrading enzymes in synovial fibroblasts. There is growing evidence that adiponectin affects osteoblasts and osteoclasts although the contribution to the aberrant bone metabolism in rheumatoid arthritis is unclear. Therefore, the adiponectin effects on rheumatoid arthritis-derived osteoblasts and osteoclasts were evaluated. METHODS: Adiponectin and its receptors were examined in bone tissue...
January 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28077868/rheumatoid-arthritis-tak-ing-the-road-to-suppress-inflammation-in-synovial-fibroblasts
#4
Mojca Frank-Bertoncelj, Steffen Gay
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28076897/microrna-expression-shows-inflammatory-dysregulation-and-tumor-like-proliferative-responses-in-joints-of-patients-with-post-infectious-lyme-arthritis
#5
Robert B Lochhead, Klemen Strle, Nancy D Kim, Minna J Kohler, Sheila L Arvikar, John M Aversa, Allen C Steere
OBJECTIVE: Lyme arthritis (LA) is caused by infection with Borrelia burgdorferi and usually resolves following spirochetal killing with antibiotics. However, in some patients, arthritis persists after antibiotic therapy. To provide insights into underlying pathogenic processes associated with post-infectious LA, we analyzed differences in microRNA expression between LA patients with active infection compared with those with post-infectious LA. METHODS: MicroRNA expression was assayed in synovial fluid (SF) from LA patients before and after oral and IV antibiotic therapy, and from synovial tissue from post-infectious LA patients obtained months after antibiotic therapy...
January 11, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28072711/the-coexistence-of-sapho-syndrome-and-rheumatoid-arthritis-a-case-report
#6
Wenrui Xu, Chen Li, Weihong Zhang
RATIONAL: SAPHO (Synovitis-Acne-Pustulosis-Hyperstosis-Osteitis) syndrome is a rare disease featured by its dermatological and osteoarthritic disorders, the latter of which mainly affecting the anterior chest wall, spine, and sacroiliac joint. However, rheumatoid arthritis (RA) is a chronic autoimmune disease, mainly affecting the synovial tissue of small joints in hands and feet. Here, we present an extremely rare case diagnosed with both SAPHO syndrome and RA, with an onset interval of 10 years...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071693/ik-acts-as-an-immunoregulator-of-inflammatory-arthritis-by-suppressing-th17-cell-differentiation-and-macrophage-activation
#7
Hye-Lim Park, Sang-Myeong Lee, Jun-Ki Min, Su-Jin Moon, Inki Kim, Kyung-Won Kang, Sooho Park, SeulGi Choi, Ha-Na Jung, Dong-Hee Lee, Jae-Hwan Nam
Pathogenic T helper cells (TH) and macrophages have been implicated in the development of rheumatoid arthritis (RA), which can lead to severe synovial inflammation and bone destruction. A range of therapies have been widely used for RA, including specific monoclonal antibodies and chemical inhibitors against inflammatory cytokines produced by these cells. However, these have not been sufficient to meet the medical need. Here, we show that in transgenic mice expressing truncated IK (tIK) cytokine, inflammatory arthritis symptoms were ameliorated as the result of suppression of the differentiation of TH1 and TH17 cells and of macrophage activation...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28067317/glucose-6-phosphate-isomerase-g6pi-mediates-hypoxia-induced-angiogenesis-in-rheumatoid-arthritis
#8
Ying Lu, Shan-Shan Yu, Ming Zong, Sha-Sha Fan, Tian-Bao Lu, Ru-Han Gong, Li-Shan Sun, Lie-Ying Fan
The higher level of Glucose-6-phosphate isomerase (G6PI) has been found in both synovial tissue and synovial fluid of rheumatoid arthritis (RA) patients, while the function of G6PI in RA remains unclear. Herein we found the enrichment of G6PI in microvascular endothelial cells of synovial tissue in RA patients, where a 3% O2 hypoxia environment has been identified. In order to determine the correlation between the high G6PI level and the low oxygen concentration in RA, a hypoxia condition (~3% O2) in vitro was applied to mimic the RA environment in vivo...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28066733/viscosupplementation-with-intra-articular-hyaluronic-acid-for-hip-disorders-a-systematic-review-and-meta-analysis
#9
Eleonora Piccirilli, Francesco Oliva, Mihaela Aconstantinesei Murè, Asmaa Mahmoud, Calogero Foti, Umberto Tarantino, Nicola Maffulli
BACKGROUND: Hip joint diseases are common in adult population and their prevalence increases with age. Osteoarthritis, rheumatoid arthritis and femoroacetabular impingement are the most common chronic diseases in the hip joint. Viscosupplementation with exogenous hyaluronic acid (HA) is one of the most widely used conservative treatment aiming to improve synovial fluid properties and to decrease pain. There is no global consensus on the type of HA, method of injection and frequency, or on its efficacy in hip joint...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28063059/experimental-arthritis-mouse-models-driven-by-adaptive-and-or-innate-inflammation
#10
W Razawy, C H Alves, M Molendijk, P S Asmawidjaja, A M C Mus, E Lubberts
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease mainly affecting synovial joints. The clinical presentation of RA shows the heterogeneity of this disease with its underlying complex interactions between the innate and adaptive immune system and flare-ups of disease. Different disease models such as collagen induced arthritis, antigen induced arthritis, and Streptococcal cell wall induced arthritis can be exploited to investigate different aspects of the pathogenesis of arthritis. The disease can be monitored macroscopically over time via scoring systems...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28058962/short-term-effect-of-ultrasound-guided-low-molecular-weight-hyaluronic-acid-injection-on-clinical-outcomes-and-imaging-changes-in-patients-with-rheumatoid-arthritis-of-the-ankle-and-foot-joints-a-randomized-controlled-pilot-trial
#11
Chien-Chih Wang, Si-Huei Lee, Hsiao-Yi Lin, Fu-Wei Liu, Hong-Jen Chiou, Rai-Chi Chan, Chen-Liang Chou
To determine whether hyaluronic acid (HA) injection into rheumatoid arthritis ankles and feet can achieve improvement in foot function and reduce synovial hyper-vascularization. Forty-four patients with RA having unilateral or bilateral painful ankle and foot involvement (N = 75) were studied. All the patients were randomized to receive HA (N = 40) or lidocaine (LI) (N = 35) injection at 2-week intervals; Clinical assessments were performed using a visual analog scale (VAS) and foot function index (FFItotal) including subscales of pain (FFIpain) before injection at baseline, 4 weeks (first evaluation) and 12 weeks (secondary evaluation)...
January 6, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28056924/anti-arthritic-activity-of-ethanol-extract-of-claoxylon-indicum-on-freund-s-complete-adjuvant-induced-arthritis-in-mice
#12
Yong Chen, Qi-Wen Wang, Jian Zuo, Jian-Wei Chen, Xiang Li
BACKGROUND: Claoxylon indicum Hassk. (Euphorbiaceae), named Diu Le Bang, have functions of dehumidification and relieving swelling pain, and is used as a folk medicine to treat Rheumatoid arthritis (RA), lumbocrural pain and foot edema in the south of China. The aim of the present study was to investigate the anti-arthritic activity of the ethanol extract of Claoxylon indicum (CIE) on mice with adjuvant induced joint arthritis. METHODS: Adjuvant arthritis was induced in mice by subcutaneous injection of complete Freund's adjuvant into the plantar surface of right hind paw...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28056105/the-impact-of-microrna-223-3p-on-il-17-receptor-d-expression-in-synovial-cells
#13
Nozomu Moriya, Seiji Shibasaki, Miki Karasaki, Tsuyoshi Iwasaki
OBJECTIVE: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting joints. Elevated plasma levels of microRNA-223-3p (miR-223-3p) in patients with RA are implicated in the pathogenesis of the disease. This study aimed to analyze the functional role of miR-223-3p in the pathogenesis of RA by overexpressing miR-223-3p in synovial cell lines. METHODS: Arthritis was induced in the RA model of SKG mice by injection of ß-glucan. The histopathologic features of joints were examined using hematoxylin and eosin and immunohistochemical staining...
2017: PloS One
https://www.readbyqxmd.com/read/28050272/adjuvant-induced-arthritis-in-guinea-pigs
#14
O S Taranov, S N Yakubitskiy, T S Nepomnyashchikh, A E Nesterov, S N Shchelkunov
We propose a model of rheumatoid arthritis (RA) induced in outbred guinea pigs using a single subcutaneous injection of complete Freund's adjuvant to the hind paw. Histological examination of this model shows fibrin deposition on the surface of the synovial membrane, leukocyte infiltration of the synovial membrane and adjacent tissues, proliferation of the granulation tissue, and emergence of angioid areas, characteristic of RA. The cell response appears as an increase in the plasma cell count and development of follicle-like lymphoid infiltrates; erosion of the articular surface of the cartilage, frequently with deep cartilage destruction over large areas; and epiphysiopathy...
October 2016: Acta Naturae
https://www.readbyqxmd.com/read/28049097/in-vivo-anti-arthritic-efficacy-of-camellia-sinensis-l-in-collagen-induced-arthritis-model
#15
Ankit Tanwar, Raman Chawla, Md Meraj Ansari, Neha, Pallavi Thakur, Ankita Singh Chakotiya, Rajeev Goel, Himanshu Ojha, M Asif, Mitra Basu, Rajesh Arora, Haider Ali Khan
BACKGROUND: Rheumatoid arthritis (RA), an autoimmune inflammatory disorder with synovial hyperplasia, destruction of cartilage, bone damage is often associated with risk of infections. Such risk could be attributed towards usage of immunosuppressive agents. Thus, the present study was undertaken to evaluate the anti-arthritic efficacy of aquo-alcoholic extract of Camellia sinensis (L.). MATERIAL AND METHODS: Dried leaves of Camellia sinensis (L.) or Cs were filtered and extracted in 1:1 aqueous: ethanol by Soxhlet apparatus followed by lyophilization and spray drying to develop amorphous powder...
December 31, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28042134/upregulation-of-thrombospondin-1-expression-in-synovial-tissues-and-plasma-of-rheumatoid-arthritis-role-of-transforming-growth-factor-%C3%AE-1-toward-fibroblast-like-synovial-cells
#16
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28039611/alternative-new-mesenchymal-stem-cell-source-exerts-tumor-tropism-through-alcam-and-n-cadherin-via-regulation-of-microrna-192-and-218
#17
Ran Kim, Sang In Park, Chang Youn Lee, Jihyun Lee, Pilseog Kim, Sekyung Oh, Hojin Lee, Min Young Lee, Jongmin Kim, Yong-An Chung, Ki-Chul Hwang, Lee-So Maeng, Woochul Chang
Gliomas are the most common type of malignant primary brain tumors. Some treatments of gliomas exist, but they are rarely curative. Mesenchymal stem cells (MSCs) are emerging as potential modes of targeted cancer therapy owing to their capacity for homing toward tumor sites. It has been proposed that MSCs derived from various sources, such as bone marrow, adipose tissue and umbilical cord blood, can be used as cell-based therapy for brain tumors. Here, MSCs obtained from the synovial fluid of osteoarthritis or rheumatoid arthritis patients were investigated as therapeutic candidates...
December 30, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28038947/ph-sensitive-polymeric-micelles-for-targeted-delivery-to-inflamed-joints
#18
Chunhong Li, Hanmei Li, Qin Wang, Meiling Zhou, Man Li, Tao Gong, Zhirong Zhang, Xun Sun
Effective treatment for rheumatoid arthritis is hindered by the lack of drugs that selectively target inflamed joints. Liposomes, nanoparticles and conventional micelles loaded with limited amounts of drugs may be unstable in the circulation and result in uncontrolled drug release kinetics. Here we developed a new drug delivery system of pH-sensitive polymeric micelles based on an acid-labile hydrazone bond. Amphiphilic conjugates of a PEG-based derivative and the hydrophobic drug prednisolone (PD) self-assembled into PD micelles with a drug loading of 19...
December 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28035365/matrine-induces-the-apoptosis-of-fibroblast-like-synoviocytes-derived-from-rats-with-collagen-induced-arthritis-by-suppressing-the-activation-of-the-jak-stat-signaling-pathway
#19
Yongsheng Yang, Qiumei Dong, Rongheng Li
The induction of apoptosis-resistant rheumatoid synovial tissue cells has been related to constitutively active Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling in rheumatoid arthritis (RA). The excessive proliferation and inherent resistance to apoptosis of fibroblast-like synoviocytes (FLS) is an important mechanism by which RA originates. However, the effects of matrine on FLS in RA is unclear. The present study aimed to investigate the mechanism of action of matrine in a rat model of collagen‑induced arthritis (CIA)...
December 29, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28032844/zaocys-type-ii-collagen-regulates-the-balance-of-treg-th17-cells-in-mice-with-collagen-induced-arthritis
#20
Hao Wang, Zhitao Feng, Junqing Zhu, Xiaoguang Chen, Xianghui Wu, Juan Li
OBJECTIVES: Zaocys type II collagen is an active collagen extracted from Zaocys that has been used to treat rheumatoid arthritis in China for over 1000 years. However, the mechanism still remains unknown. Therefore, we set out to investigate the inhibitory effect and possible mechanism of action of zaocys type II collagen on collagen-induced arthritis. METHODS: Collagen-induced arthritis was induced in C57BL/6 mice by immunisation with type II collagen. After immunisation, the mice were treated with Zaocys type II collagen...
December 28, 2016: Clinical and Experimental Rheumatology
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