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JOURNAL ARTICLE
Alexandra Cîrciumaru, Yogan Kisten, Monika Hansson, Linda Mathsson-Alm, Vijay Joshua, Heidi Wähämaa, Malena Loberg Haarhaus, Joakim Lindqvist, Leonid Padyukov, Sergiu-Bogdan Catrina, Guozhong Fei, Nancy Vivar, Hamed Rezaei, Erik Af Klint, Aleksandra Antovic, Bence Réthi, Anca I Catrina, Aase Hensvold
OBJECTIVE: Individuals positive for anti-cyclic-peptide-antibodies (anti-CCP) and musculoskeletal complaints (MSK-C) are at risk for developing rheumatoid arthritis (RA). In this study we aimed to investigate factors involved in arthritis progression. METHODS: Anti-CCP2-positive individuals with MSK-C referred to a rheumatologist were recruited. Individuals lacked arthritis at clinical and ultrasound examination and were followed for ≥three years or until clinical arthritis diagnosis...
March 8, 2024: Rheumatology
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JOURNAL ARTICLE
Lucy Law, Per Lindqvist, Per Liv, Urban Hellman, Kristina Lejon, Mats Geijer, Stefan Söderberg, Helena Forsblad-d'Elia
OBJECTIVE: There is an increased risk for cardiovascular disease (CVD) in patients with radiographic axial spondyloarthritis (r-axSpA). In this cross-sectional study, we aimed to, overall and stratified by sex, (i) compare ultrasound derived carotid intima media thickness (cIMT), between patients and controls, and (ii) investigate associations between cIMT, clinical disease activity and inflammation-related laboratory markers in patients with r-axSpA. METHOD: In total, 155 patients diagnosed with r-axSpA using the modified New York criteria and 400 controls were included...
March 6, 2024: Clinical Rheumatology
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Marco Aurelio Ramírez Huaranga, David Velasco Sánchez, Luis Ángel Calvo Pascual, David Castro Corredor, María Dolores Mínguez Sánchez, Verónica Salas Manzanedo, Eva Revuelta Evrard, Rocío Arenal López, Joaquín Anino Fernández, Marina González Peñas, Lourdes Martin de la Sierra López, Laura María Jiménez Rodríguez, Alberto López Menchero Mora, Marcos Paulino Huertas
UNLABELLED: Rheumatoid Arthritis (RA) has a mortality rate 1,3 to 3 times higher than the general population, with cardiovascular mortality accounting for 40-50% of cases. Currently, cardiovascular disease is considered an extraarticular manifestation of RA (OR: 1,5-4,0). Ultrasound measurement of the intima-media thickness (IMT) of the common carotid artery and the presence of atherosclerotic plaques (AP) is a non-invasive method and a surrogate marker of subclinical arteriosclerosis...
March 4, 2024: Reumatología clinica
#24
JOURNAL ARTICLE
Andrea Di Matteo, Gianluca Smerilli, Stefano Di Donato, An Ran Liu, Andrea Becciolini, Federica Camarda, Tomas Cazenave, Edoardo Cipolletta, Davide Corradini, Juan José de Agustín, Giulia Maria Destro Castaniti, Eleonora Di Donato, Luca Di Geso, Emine Duran, Bayram Farisogullari, Marco Fornaro, Francesca Francioso, Pamela Giorgis, Amelia Granel, Cristina Hernández-Díaz, Rudolf Horvath, Jana Hurnakova, Diogo Jesus, Omer Karadag, Ling Li, Josefina Marin, María Victoria Martire, Xabier Michelena, Erica Moscioni, Laura Muntean, Matteo Piga, Marcos Rosemffet, João Rovisco, Didem Sahin, Fausto Salaffi, Liliana Saraiva, Crescenzio Scioscia, Maria-Magdalena Tamas, Shun Tanimura, Aliki Venetsanopoulou, Lucio Ventura-Rios, Orlando Villota, Catalina Villota-Eraso, Paraskevi V Voulgari, Gentiana Vukatana, Johana Zacariaz Hereter, Helena Marzo-Ortega, Walter Grassi, Emilio Filippucci
OBJECTIVES: To assess, in spondyloarthritis (SpA), the discriminative value of the Outcome Measures in Rheumatology (OMERACT) ultrasound lesions of enthesitis and their associations with clinical features in this population. METHODS: In this multicentre study involving 20 rheumatology centres, clinical and ultrasound examinations of the lower limb large entheses were performed in 413 patients with SpA (axial SpA and psoriatic arthritis) and 282 disease controls (osteoarthritis and fibromyalgia)...
March 5, 2024: Annals of the Rheumatic Diseases
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REVIEW
Kevin D Deane
PURPOSE OF REVIEW: This review discusses updates in the prediction and prevention of future rheumatoid arthritis (RA). RECENT FINDINGS: In individuals with musculoskeletal symptoms and elevated antibodies to citrullinated proteins (ACPA) without clinical inflammatory arthritis (IA), a 'simple' score has a positive predictive value (PPV) of ∼28% for clinical IA/RA within 1 year, and a comprehensive score (including ultrasound) has a PPV of ∼71% for clinical RA within 5 years...
May 1, 2024: Current Opinion in Rheumatology
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JOURNAL ARTICLE
M Naumovska, U Dahlstrand, L Engqvist, M Cinthio, J Albinsson, R Sheikh, A Merdasa, M Malmsjo
OBJECTIVE: Conventional two-dimensional ultrasound has been assessed for the non-invasive diagnosis of giant cell arteritis (GCA), but the results are operator dependent, resulting in low sensitivity. Tomographic three-dimensional (3D) ultrasound is a novel technique that enables the objective documentation of vessel geometry. Here, for the first time, its utility is assessed for visualizing temporal arteries. METHOD: The temporal artery of 14 healthy subjects and three subjects with suspected GCA was examined using tomographic 3D ultrasound...
March 4, 2024: Scandinavian Journal of Rheumatology
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JOURNAL ARTICLE
Robyn Boman, Stefania Penkala, Rosa H M Chan, Fredrick Joshua, Roy Tsz Hei Cheung
INTRODUCTION: Clinical verification of rheumatoid vasculitis (RV) persists as a mid-to-late diagnosis with medical imaging or biopsy. Early and subclinical presentations of RV, in particular, can remain underdiagnosed in the absence of adequate diagnostic testing. In this study, the research demonstrated the precursory changes for RV in patients with rheumatoid arthritis (RA) using non-invasive ultrasound imaging of a peripheral vessel. METHOD: Six participants were recruited: three participants with (RA) and three age- and gender-matched healthy controls...
February 2024: Australasian Journal of Ultrasound in Medicine
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Marta Serrano-Warleta, Aliuska Palomeque-Vargas, Rosa Manzo, Boris Blanco-Cáceres, Mónica Vazquez-Díaz, Carlos Guillen-Astete
OBJECTIVE: The purpose of the present study is to identify the extent to which it affects clinical decisions in a single-centre observational retrospective study. METHOD: The results of 801 requests and 1174 consecutive individual ultrasound examinations performed over 10 months were analysed. RESULTS: The most frequent indication was diagnostic assistance (39%) followed by assessment of inflammatory activity (34%). By topography, the hand was the most frequently studied region (51%), followed by the foot (18...
March 1, 2024: Reumatología clinica
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JOURNAL ARTICLE
Beatriz Frade-Sosa, Andrés Ponce, Estíbaliz Ruiz-Ortiz, Noemí De Moner, María J Gómara, Ana Belén Azuaga, Juan C Sarmiento-Monroy, Rosa Morlà, Virginia Ruiz-Esquide, Laura Macías, Nuria Sapena, Lola Tobalina, Julio Ramirez, Juan D Cañete, Jordi Yague, Josep M Auge, José A Gomez-Puerta, Odette Viñas, Isabel Haro, Raimon Sanmarti
INTRODUCTION: This study assesses the accuracy of neutrophil activation markers, including neutrophil extracellular traps (NETs) and calprotectin, as biomarkers of disease activity in patients with established rheumatoid arthritis (RA). We also analyse the relationship between NETs and various types of therapies as well as their association with autoimmunity. METHODS: Observational cross-sectional study of patients with RA receiving treatment with biological disease-modifying antirheumatic drugs or Janus kinase inhibitors (JAK-inhibitors) for at least 3 months...
March 2, 2024: Rheumatology and Therapy
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JOURNAL ARTICLE
Mingzhu Zhou, Shanshan Zhang, Xiaoyan Xie, Wei Li, Li Cui, Hanxue Zhao, Sumei Tang, Xiangdong Hu, Shanshan Wu, Jiajing Peng, Huilian Huang, Wei Ren, Ying Zhang, Ning Xu, Pengfei Sun, Yiqun Liu, Zuyan Zhang, Guangyan Yu, Yanying Liu, Yin Su
OBJECTIVES: To develop a novel ultrasound scoring system for the major salivary glands in patients with immunoglobulin G4-related sialadenitis (IgG4-RS) and assess its diagnostic value in a multicenter cohort of Chinese patients. METHODS: Twenty clinicians (rheumatologists, stomatologists, and radiologists) participated. The study was conducted in four steps: (1) defining the ultrasonography (US) elements, (2) developing a novel ultrasound scoring system for US of the salivary glands, (3) evaluation of inter- and intra-reader reliabilities using the new ultrasound scoring system, and (4) assessing the diagnostic value of this novel ultrasound scoring system in IgG4-RS patients in a Chinese multicenter cohort...
March 1, 2024: Rheumatology
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JOURNAL ARTICLE
Tianmin Tang, Hongyu Jin, Yujia Yang
BACKGROUND: The European League Against Rheumatism-Outcomes Measures in Rheumatology (EULAR-OMERACT) recommend only scanning dorsal spaces for scoring ultrasound-detected hand synovitis. This study evaluated the efficiency of the combined scoring system only depending on dorsal joint spaces synovitis in diagnosing and evaluating ultrasound-detected hand synovitis. METHODS: The data of 56 patients who underwent hand joint ultrasonography exams in the Ultrasound Department of West China Hospital, Sichuan University were prospectively collected...
February 1, 2024: Quantitative Imaging in Medicine and Surgery
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JOURNAL ARTICLE
Hanna Gul, Andrea Di Matteo, Innocent Anioke, Farag Shuweidhi, Kulveer Mankia, Frederique Ponchel, Paul Emery
OBJECTIVE: The tapering of biologic disease-modifying antirheumatic drug (b-DMARD) therapy for patients with rheumatoid arthritis (RA) in stable remission is frequently undertaken, but specific guidance on how to successfully taper is lacking. The objective of this study is to identify predictors of flare in patients in stable b-DMARD-induced clinical remission, who did or did not follow structured b-DMARD tapering. METHODS: Patients with RA receiving b-DMARD treatment who had achieved sustained remission according to a Disease Activity Score in 28 joints using the C-reactive protein level (DAS28-CRP) <2...
February 27, 2024: ACR open rheumatology
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JOURNAL ARTICLE
Yan Sheng Liu, Gui Jia, Da Wei Ding, Lin Hua Zheng, Rui Qing Sun, Xiu Fang Wang, Juan Deng, Chun Mei Yang, Li Na Cui, Chang Cun Guo, Yu Long Shang, Ying Han
OBJECTIVES: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease that affects the quality of life (QoL) of patients. This study aimed to evaluate the differences in perceptions of PBC among physicians from different hospital departments and patients with PBC. METHODS: An online survey regarding the general knowledge, diagnosis, and management of PBC was completed by physicians and patients. RESULTS: A total of 239 patients with PBC and 239 physicians from eight hospital departments (gastroenterology, infectious diseases, rheumatology, hepatobiliary surgery, pathology, clinical laboratory, ultrasound, and radiology) completed the survey...
January 2024: Journal of Digestive Diseases
#34
JOURNAL ARTICLE
Alisa J Johnson, Sarah M Barron, Jennifer A Nichols, Yenisel Cruz-Almeida
OBJECTIVE: Knee osteoarthritis (OA) is a leading cause of chronic pain in adults and shows wide interindividual variability, with peripheral and central factors contributing to the pain experience. Periarticular factors, such as muscle quality (eg, echo intensity [EI] and shear wave velocity [SWV]), may contribute to knee OA pain; however, the role of muscle quality in OA symptoms has yet to be fully established. METHODS: Twenty-six adults (age >50 years) meeting clinical criteria for knee OA were included in this cross-sectional study...
February 25, 2024: Arthritis & Rheumatology
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JOURNAL ARTICLE
Andrea Delle Sedie, Lene Terslev, George A W Bruyn, Tomas Cazenave, Stavros Chrysidis, Mario Diaz, Marco Di Carlo, Marilena Frigato, Luna Gargani, Marwin Gutierrez, Alojzija Hocevar, Annamaria Iagnocco, Aaron Juche, Helen Keen, Peter Mandl, Esperanza Naredo, Mohamed Mortada, Carlos Pineda, Rositsa Karalilova, Francesco Porta, Viviana Ravagnani, Carlo Scirè, Teodora Serban, Kate Smith, Maria S Stoenoiu, Marika Tardella, Karina Torralba, Richard Wakefield, Maria Antonietta D'Agostino
OBJECTIVES: Over the last years ultrasound has shown to be an important tool for evaluating lung involvement, including interstitial lung disease (ILD) a potentially severe systemic involvement in many rheumatic and musculoskeletal diseases (RMD). Despite the potential sensitivity of the technique the actual use is hampered by the lack of consensual definitions of elementary lesions to be assessed and of the scanning protocol to apply. Within the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group we aimed at developing consensus-based definitions for ultrasound detected ILD findings in RMDs and assessing their reliability in dynamic images...
February 5, 2024: Seminars in Arthritis and Rheumatism
#36
REVIEW
Diane Lewis Horowitz, Arthur M Mandelin, Darren Tabechian, Ami Ben-Artzi
PURPOSE OF REVIEW: In the clinical evaluation of inflammatory arthritis and the research into its pathogenesis, there is a growing role for the direct analysis of synovial tissue. Over the years, various biopsy techniques have been used to obtain human synovial tissue samples, and there have been progressive improvements in the safety, tolerability, and utility of the procedure. RECENT FINDINGS: The latest advancement in synovial tissue biopsy techniques is the use of ultrasound imaging to guide the biopsy device, along with evolution in the characteristics of the device itself...
February 20, 2024: Current Rheumatology Reports
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JOURNAL ARTICLE
Baptiste Quéré, Alain Saraux, Guillermo Carvajal-Alegria, Dewi Guellec, Gaël Mouterde, Christophe Lamotte, Daniel Hammenfors, Malin Jonsson, Sung-Eun Choi, Min Hong-Ki, Alja Stel, Benjamin A Fisher, Mark Maybury, Benedikt Hofauer, Francesco Ferro, Vera Milic, Dana Direnzo, Valérie Devauchelle-Pensec, Sandrine Jousse-Joulin
INTRODUCTION: Major salivary gland ultrasonography (SGUS) demonstrated its good metric properties as an outcome measure for diagnosing primary Sjögren's disease (SD). The objective was to assess SGUS reliability among sonographers with different levels of experience, using web training. METHODS: Sonographers from expert centers participated in the reliability exercise. Before exercises, training was done by videoconferencing. Reliability of the two most experienced sonographers (MES) was assessed and then compared to other sonographers...
February 19, 2024: Rheumatology and Therapy
#38
JOURNAL ARTICLE
M Otaola, F Paulin, M Rosemffet, J Balcazar, M Perandones, P Orausclio, T Cazenave, S Rossi, S Marciano, E Schneeberger, G Citera
BACKGROUND AND OBJECTIVE: It is still controversial how to screen for interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA). We aimed to evaluate the performance of lung ultrasound (LUS) as a screening tool for RA-ILD and to compare it with the performance of chest auscultation, chest x-ray and pulmonary function tests (PFTs). METHODS: Cross-sectional study of consecutive RA patients evaluated at a Rheumatology Clinic in Buenos Aires between January and December 2022...
February 18, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
#39
JOURNAL ARTICLE
Samy Slimani, Amel Aissoug, Souhila Aouidane, Nacif Eddine Ghodbane, Aicha Ladjouze-Rezig
BACKGROUND: Intra-articular glucocorticoid injection (IAGI) is widely used for treatment of knee osteoarthritis (OA) flares. Response rates are generally around 70%. Several studies have tried to identify predictors of good response, but response to ultrasound (US)-guided injection has not yet been investigated. This study aimed to identify the predictors of response to IAGI performed under US guidance in patients with primary knee OA. MATERIALS AND METHODS: A total of 116 patients (116 knees) presenting with unilateral or bilateral primary knee OA were enrolled for this prospective single-center study...
February 13, 2024: ARP Rheumatol
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JOURNAL ARTICLE
Valentin S Schäfer, Christian Dejaco, Pantelis Karakostas, Charlotte Behning, Peter Brossart, Lara C Burg
OBJECTIVES: Ultrasound is a standard tool to diagnose giant cell arteritis (GCA). Until now, only few studies investigated the role of ultrasound in the follow-up of GCA. The aim of this study was to assess the changes in the intima media thickness (IMT), total number of affected arteries and provisional OMERACT GCA ultrasonography score (OGUS) in a 12-months follow-up period. METHODS: Patients with newly diagnosed GCA were prospectively enrolled. Ultrasound examinations of facial, temporal, carotid, vertebral and axillary arteries were performed at baseline, after three, six, nine and 12 months...
February 15, 2024: Rheumatology
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