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JOURNAL ARTICLE
Juliana Giselbrecht, Stéphanie Jähne, Michèle Bergmann, Marina L Meli, Svenja Teichmann-Knorrn, Yury Zablotski, Maria-Grazia Pennisi, Nicolas Layachi, Rodrigo Serra, Stefano Bo, Regina Hofmann-Lehmann, Katrin Hartmann
The first point-of-care (PoC) test (v-RetroFel® ; modified version 2021) determining the presence of FeLV p27 antigen and FeLV anti-p15E antibodies has become recently commercially available to identify different feline leukaemia virus (FeLV) infection outcomes. This study aimed to assess this PoC test's performance concerning FeLV p27 antigen and FeLV anti-p15E antibody detection. Sensitivity, specificity, positive and negative predictive values (PPV, NPV) were assessed after ten minutes (recommended) and 20 min (prolonged) incubation times...
April 15, 2024: Viruses
#2
JOURNAL ARTICLE
Tori Brown, Alice Defarges, Gabrielle Monteith, Ryan Appleby, Dorothee Bienzle
OBJECTIVES: The aim of the present study was to establish a reference interval (RI) for urine kidney injury molecule-1 (KIM-1) in healthy cats. METHODS: History, physical examination, blood pressure, and feline immunodeficiency virus and feline leukemia virus serology status were determined. A complete blood cell count, serum biochemical profile, urinalysis and kidney ultrasound were performed, and N-terminal pro-brain natriuretic peptide, total thyroxine (TT4) and urine KIM-1 were measured...
April 2024: Journal of Feline Medicine and Surgery
#3
JOURNAL ARTICLE
Laura Gallina, Veronica Facile, Nicola Roda, Maria Chiara Sabetti, Alessia Terrusi, Lorenza Urbani, Martina Magliocca, Kateryna Vasylyeva, Francesco Dondi, Andrea Balboni, Mara Battilani
Feline leukemia virus (FeLV) is responsible for feline leukemia syndrome in domestic cats. The prevention and control of disease caused by FeLV are primarily based on vaccination and identification and isolation of infected subjects. Antigen diagnostic methods, which are the most widely used in clinical practices, can be associated to molecular tests to characterize the FeLV detected. In this study, a quantitative SYBR Green Real-Time PCR (qPCR) assay was used to detect FeLV proviral DNA in blood samples from antigen positive cats referred to a veterinary teaching hospital in Northern Italy in 2018-2021...
April 22, 2024: Veterinary Research Communications
#4
JOURNAL ARTICLE
Luiz Fernando de Jesus Nascimento, Ana Carolina Amado-Gomes, Filipe Dantas-Torres, Fred Luciano Neves Santos, Wemerson de Santana Neres, Pedro Estevão de Souza Filho, Mariana Tibúrcio Santos, José Rodrigo Santos Silva, Cláudia Fideles Resende, Jenner Karlisson Pimenta Dos Reis, Sona Jain, João Luís Reis Cunha, Ricardo Toshio Fujiwara, Silvio Santana Dolabella
Infection and clinical cases of leishmaniasis caused by Leishmania infantum in cats have been increasingly reported in several countries, including Brazil. In this study, we used an enzyme-linked immunosorbent assay (ELISA) and an immunochromatographic test (ICT) based on a recombinant antigen (rKDDR-plus) to detect anti-Leishmania antibodies in cats from an animal shelter in northeastern Brazil. We compared the results with an ELISA using L. infantum crude antigen (ELISA-CA). We also investigated the presence of Leishmania DNA in blood or ocular conjunctival samples as well as the association between Leishmania PCR positivity and serological positivity to feline immunodeficiency virus (FIV), feline leukemia virus (FeLV) and Toxoplasma gondii...
April 9, 2024: Research in Veterinary Science
#5
JOURNAL ARTICLE
Laura Pancich Diesel, Lauren Santos de Mello, Weslei de Oliveira Santana, Nilo Ikuta, André Salvador Kazantzi Fonseca, Diéssy Kipper, Raquel Redaelli, Vagner Reinaldo Zingali Bueno Pereira, André Felipe Streck, Vagner Ricardo Lunge
Feline leukemia virus (FeLV) is a retrovirus distributed worldwide in domestic cats and with different outcomes (progressive, regressive, abortive, focal). The present study reports an epidemiological survey of FeLV frequency and the evaluation of some risk factors and the two main disease outcomes (progressive and regressive) in an urban cat population from Brazil. A total of 366 cats with sociodemographic information and p27 FeLV antigen test performed were included in the study. FeLV DNA (provirus) in the blood samples of all cats was detected via real-time polymerase chain reaction (qPCR)...
March 29, 2024: Animals: An Open Access Journal From MDPI
#6
REVIEW
Veronica Fiorito, Emanuela Tolosano
The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a member of the SLC49 Major Facilitator Superfamily of transporters. Initially recognized as the receptor for the retrovirus responsible of pure red cell aplasia in cats, nearly two decades since its discovery, FLVCR1a remains a puzzling transporter, with ongoing discussions regarding what it transports and how its expression is regulated. Nonetheless, despite this, the substantial body of evidence accumulated over the years has provided insights into several critical processes in which this transporter plays a complex role, and the health implications stemming from its malfunction...
April 6, 2024: Cellular and Molecular Life Sciences: CMLS
#7
JOURNAL ARTICLE
Marina L Meli, Benita Pineroli, Esther Geisser, Regina Hofmann-Lehmann
Feline leukemia virus (FeLV) remains a serious concern in some countries despite advances in diagnostics and vaccines. FeLV-infected cats often have reduced lifespans due to FeLV-associated diseases. The infection is transmitted through social interactions. While Northern European countries have reported a decrease in FeLV among pet cats, Switzerland's rates remain stagnant at 2.7% (2016/17: 95% CI 1.4-5.2%). Research on FeLV in Swiss stray cats has been lacking, even though these animals could serve as a virus reservoir...
March 2, 2024: Viruses
#8
JOURNAL ARTICLE
Qiaoyu Zhou, Ruizheng Shi
BACKGROUND: Increasing evidence suggests a higher propensity for acute myocardial infarction (MI) in patients with psoriasis. However, the shared mechanisms underlying this comorbidity in these patients remain unclear. This study aimed to explore the shared genetic features of psoriasis and MI and to identify potential biomarkers indicating their coexistence. METHODS AND RESULTS: Data sets obtained from the gene expression omnibus were examined using a weighted gene coexpression network analysis approach...
March 27, 2024: Journal of the American Heart Association
#9
JOURNAL ARTICLE
Mônica Slaviero, Fernanda G Cony, Rodrygo C da Silva, Cíntia De Lorenzo, Bruno A de Almeida, Marianna Bertolini, David Driemeier, Saulo P Pavarini, Luciana Sonne
Feline infectious peritonitis (FIP) is an important cause of death in cats. Thoracic manifestations are less common than abdominal manifestations, and FIP-associated respiratory disease is poorly documented. This study aimed to investigate pathological findings in the respiratory tract of cats with FIP and the occurrence and distribution of feline coronavirus antigen in the respiratory tract using immunohistochemistry. A retrospective study was carried out on 112 cats with FIP, of which 66 had inflammatory histological lesions in the respiratory tract (58...
April 2024: Journal of Comparative Pathology
#10
JOURNAL ARTICLE
José Artur Brilhante Bezerra, Camila Pontes Landim, Yara Stephanne Ramos Ribeiro, Moisés Dantas Tertulino, Ricardo de Freitas Santos Junior, Ana Carolina Pontes de Miranda Maranhão, Arthur Willian de Lima Brasil, João Marcelo Azevedo de Paula Antunes, Sérgio Santos de Azevedo
Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are retroviruses of great importance for domestic cats with a worldwide distribution. A retrospective study was conducted to determine the epidemiological and clinicopathological aspects of the infection by FIV and FeLV in cats from the Brazilian semiarid region. Cats treated between 2011 and 2021 at the teaching veterinary hospital of the Federal Rural University of the Semi-Arid Region that were submitted to a point-of-care (POC) test to detect anti-FIV IgG antibodies and FeLV antigen were enrolled in the study...
March 6, 2024: Preventive Veterinary Medicine
#11
JOURNAL ARTICLE
Fernando Nájera, Guillermo López, Tere Del Rey-Wamba, Rimsha A Malik, Germán Garrote, Marcos López-Parra, Leonardo Fernández-Pena, Maribel García-Tardío, Rafael Arenas-Rojas, Miguel A Simón, Irene Zorrilla, Isabel Fernández, Eva M Alcaide, Carmen Ruiz, Luis Revuelta, Javier Salcedo, Regina Hofmann-Lehmann, Marina L Meli
Feline leukemia virus (FeLV) infection is considered one of the most serious disease threats for the endangered Iberian lynx (Lynx pardinus) Over 14 years (2008-2021), we investigated FeLV infection using point-of-care antigen test and quantitative real-time TaqMan qPCR for provirus detection in blood and tissues in lynxes from Andalusia (Southern Spain). A total of 776 samples from 586 individuals were included in this study. The overall prevalence for FeLV antigen in blood/serum samples was 1.4% (5/360) (95% CI: 0...
March 5, 2024: Scientific Reports
#12
JOURNAL ARTICLE
Didik Pramono, Dai Takeuchi, Masato Katsuki, Loai AbuEed, Dimas Abdillah, Tohru Kimura, Junna Kawasaki, Ariko Miyake, Kazuo Nishigaki
Endogenous retroviruses (ERVs) are remnants of ancestral viral infections. Feline leukemia virus (FeLV) is an exogenous and endogenous retrovirus in domestic cats. It is classified into several subgroups (A, B, C, D, E, and T) based on viral receptor interference properties or receptor usage. ERV-derived molecules benefit animals, conferring resistance to infectious diseases. However, the soluble protein encoded by the defective envelope ( env ) gene of endogenous FeLV (enFeLV) functions as a co-factor in FeLV subgroup T infections...
March 5, 2024: Journal of Virology
#13
JOURNAL ARTICLE
Miriam Mistretta, Veronica Fiorito, Anna Lucia Allocco, Giorgia Ammirata, Myriam Y Hsu, Sabrina Digiovanni, Marzia Belicchi, Laura Napoli, Michela Ripolone, Elena Trombetta, PierLuigi Mauri, Andrea Farini, Mirella Meregalli, Chiara Villa, Paolo Ettore Porporato, Barbara Miniscalco, Simonetta Geninatti Crich, Chiara Riganti, Yvan Torrente, Emanuela Tolosano
The definition of cell metabolic profile is essential to ensure skeletal muscle fiber heterogeneity and to achieve a proper equilibrium between the self-renewal and commitment of satellite stem cells. Heme sustains several biological functions, including processes profoundly implicated with cell metabolism. The skeletal muscle is a significant heme-producing body compartment, but the consequences of impaired heme homeostasis on this tissue have been poorly investigated. Here, we generate a skeletal-muscle-specific feline leukemia virus subgroup C receptor 1a (FLVCR1a) knockout mouse model and show that, by sustaining heme synthesis, FLVCR1a contributes to determine the energy phenotype in skeletal muscle cells and to modulate satellite cell differentiation and muscle regeneration...
February 26, 2024: Cell Reports
#14
Daniel G Calame, Jovi Huixin Wong, Puravi Panda, Dat Tuan Nguyen, Nancy C P Leong, Riccardo Sangermano, Sohil G Patankar, Mohamed Abdel-Hamid, Lama AlAbdi, Sylvia Safwat, Kyle P Flannery, Zain Dardas, Jawid M Fatih, Chaya Murali, Varun Kannan, Timothy E Lotze, Isabella Herman, Farah Ammouri, Brianna Rezich, Stephanie Efthymiou, Shahryar Alavi, David Murphy, Zahra Firoozfar, Mahya Ebrahimi Nasab, Amir Bahreini, Majid Ghasemi, Nourelhoda A Haridy, Hamid Reza Goldouzi, Fatemeh Eghbal, Ehsan Ghayoor Karimiani, Varunvenkat M Srinivasan, Vykuntaraju K Gowda, Haowei Du, Shalini N Jhangiani, Zeynep Coban-Akdemir, Dana Marafi, Lance Rodan, Sedat Isikay, Jill A Rosenfeld, Subhadra Ramanathan, Michael Staton, Kerby C Oberg, Robin D Clark, Catharina Wenman, Sam Loughlin, Ramy Saad, Tazeen Ashraf, Alison Male, Shereen Tadros, Reza Boostani, Ghada M H Abdel-Salam, Maha Zaki, Ebtesam Abdalla, M Chiara Manzini, Davut Pehlivan, Jennifer E Posey, Richard A Gibbs, Henry Houlden, Fowzan S Alkuraya, Kinga Bujakowska, Reza Maroofian, James R Lupski, Long Nam Nguyen
FLVCR1 encodes Feline leukemia virus subgroup C receptor 1 (FLVCR1), a solute carrier (SLC) transporter within the Major Facilitator Superfamily. FLVCR1 is a widely expressed transmembrane protein with plasma membrane and mitochondrial isoforms implicated in heme, choline, and ethanolamine transport. While Flvcr1 knockout mice die in utero with skeletal malformations and defective erythropoiesis reminiscent of Diamond-Blackfan anemia, rare biallelic pathogenic FLVCR1 variants are linked to childhood or adult-onset neurodegeneration of the retina, spinal cord, and peripheral nervous system...
February 13, 2024: medRxiv
#15
JOURNAL ARTICLE
Marta Manco, Giorgia Ammirata, Sara Petrillo, Francesco De Giorgio, Simona Fontana, Chiara Riganti, Paolo Provero, Sharmila Fagoonee, Fiorella Altruda, Emanuela Tolosano
Feline leukemia virus C receptor 1a (FLVCR1a), initially identified as a retroviral receptor and localized on the plasma membrane, has emerged as a crucial regulator of heme homeostasis. Functioning as a positive regulator of δ-aminolevulinic acid synthase 1 (ALAS1), the rate-limiting enzyme in the heme biosynthetic pathway, FLVCR1a influences TCA cycle cataplerosis, thus impacting TCA flux and interconnected metabolic pathways. This study reveals an unexplored link between FLVCR1a, heme synthesis, and cholesterol production in endothelial cells...
January 26, 2024: Biomolecules
#16
JOURNAL ARTICLE
Elliott S Chiu, Coby A McDonald, Roderick B Gagne, Henry Dunkleberger, Matthew Moxcey, Sue VandeWoude
Endogenous retroviruses (ERV) are indicators of vertebrate evolutionary history and play important roles as homeostatic regulators. ERV long terminal repeat (LTR) elements may act as cis-activating promoters or trans-activating enhancer elements modifying gene transcription distant from LTR insertion sites. We previously documented that endogenous feline leukemia virus (FeLV)-LTR copy number variation in individual cats tracks inversely with susceptibility to virulent FeLV disease. To evaluate FeLV-LTR insertion characteristics, we assessed enFeLV-LTR integration site diversity in 20 cats from three genetically distinct populations using a baited linker-mediated PCR approach...
February 12, 2024: Retrovirology
#17
JOURNAL ARTICLE
Sylvia Safwat, Kyle P Flannery, Ahmed A El Beheiry, Mohamed M Mokhtar, Ebtesam Abdalla, M Chiara Manzini
Congenital muscular dystrophies (CMDs) are a group of rare muscle disorders characterized by early onset hypotonia and motor developmental delay associated with brain malformations with or without eye anomalies in the most severe cases. In this study, we aimed to uncover the genetic basis of severe CMD in Egypt and to determine the efficacy of whole exome sequencing (WES)-based genetic diagnosis in this population. We recruited twelve individuals from eleven families with a clinical diagnosis of CMD with brain malformations that fell into two groups: seven patients with suspected dystroglycanopathy and five patients with suspected merosin-deficient CMD...
February 1, 2024: Neurogenetics
#18
JOURNAL ARTICLE
José Artur Brilhante Bezerra, Amanda Haisi, Gabrielle Dos Santos Rocha, Suellen Gonçalves Lima, Arthur Willian de Lima Brasil, Klívio Loreno Raulino Tomaz, Felipe Fornazari, Helio Langoni, João Pessoa Araújo Junior, João Marcelo Azevedo de Paula Antunes, Sérgio Santos de Azevedo
The aim of this study was to investigate the coinfection of feline retroviruses (feline immunodeficiency virus-FIV, and the feline leukemia virus-FeLV) with Leishmania infantum and Toxoplasma gondii and the factors associated with these pathogens in domestic cats from Mossoró, a city endemic for canine and human leishmaniasis situated in the semiarid region of Northeast Brazil. Blood samples from 120 cats were collected, and an epidemiological questionnaire was applied to investigate the risk factors associated with the infections...
December 29, 2023: Microorganisms
#19
JOURNAL ARTICLE
Minh Ha Ngo, Loai AbuEed, Junna Kawasaki, Naoki Oishi, Didik Pramono, Tohru Kimura, Masashi Sakurai, Kenji Watanabe, Yoichi Mizukami, Haruyo Ochi, Yukari Anai, Yuka Odahara, Daigo Umehara, Maki Kawamura, Shinya Watanabe, Ariko Miyake, Kazuo Nishigaki
Feline leukemia virus (FeLV) is an exogenous retrovirus that causes malignant hematopoietic disorders in domestic cats, and its virulence may be closely associated with viral sequences. FeLV is classified into several subgroups, including A, B, C, D, E, and T, based on viral receptor interference properties or receptor usage. However, the transmission manner and disease specificity of the recombinant viruses FeLV-D and FeLV-B remain unclear. The aim of this study was to understand recombination events between exogenous and endogenous retroviruses within a host and elucidate the emergence and transmission of recombinant viruses...
January 19, 2024: Journal of Virology
#20
JOURNAL ARTICLE
Daniela Losada-Medina, Ana M Henao-Duque, Diana I Buitrago-Grisales, Juliana Peña-Stadlin
OBJECTIVE: To describe the clinical presentation, progression, and diagnosis of acute myeloid leukemia (AML) with neutrophilic differentiation in an African lion (Panthera leo). ANIMAL: A 12-year-old male African lion kept at a zoological institution in Colombia. CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES: The lion presented for anorexia, pale mucous membranes, and a hind limb lameness of acute onset. Feline leukemia virus testing was negative, and repeated blood samples revealed severe anemia, intermittent thrombocytopenia, lymphopenia, and neutrophilia...
January 3, 2024: Journal of the American Veterinary Medical Association
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