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feline leukemia virus

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https://www.readbyqxmd.com/read/29911463/body-composition-of-lean-outdoor-intact-cats-vs-lean-indoor-neutered-cats-using-dual-energy-x-ray-absorptiometry
#1
Martha G Cline, Angela L Witzel, Tamberlyn D Moyers, Claudia A Kirk
Objectives The objectives for this study were to compare the body composition of adult indoor neutered domestic cats with outdoor intact cats with an ideal body condition score using dual-energy x-ray absorptiometry, and to report the body composition findings of free-roaming cats, as this has not been previously reported. Most domestic house cats differ from free-roaming cats as they are confined indoors and neutered. Indoor neutered cats have reduced activity and hormonal alterations that may result in lower muscle mass and higher body fat percentages vs outdoor intact cats, despite similar body condition scores...
June 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29906285/murine-leukemia-virus-p12-tethers-the-capsid-containing-pre-integration-complex-to-chromatin-by-binding-directly-to-host-nucleosomes-in-mitosis
#2
Madushi Wanaguru, David J Barry, Donald J Benton, Nicola J O'Reilly, Kate N Bishop
The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early and late steps in viral replication. The N-terminal domain of p12 binds directly to capsid (CA) and stabilises the mature viral core, whereas defects in the C-terminal domain (CTD) of p12 can be rescued by addition of heterologous chromatin binding sequences (CBSs). We and others hypothesised that p12 tethers the pre-integration complex (PIC) to host chromatin ready for integration. Using confocal microscopy, we have observed for the first time that CA localises to mitotic chromatin in infected cells in a p12-dependent manner...
June 15, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29905922/health-and-ecological-aspects-of-stray-cats-in-old-san-juan-puerto-rico-baseline-information-to-develop-an-effective-control-program
#3
Jessica Castro-Prieto, Maria José Andrade-Núñez
The overpopulation of stray cats in urban areas represents a potential risk for humans, as stray cats may carry diseases, such as toxoplasmosis, and virus such as rabies, the feline immunodeficiency, and the feline leukemia. In Old San Juan, a historic neighborhood and one of the most touristic places in Puerto Rico, there is an overpopulation of stray cats. In this study, we generated baseline information fundamental to developing a successful control program by estimating the stray cat population size, density, and spatial distribution...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29872537/-pentatrichomonas-hominis-infection-in-two-domestic-cats-with-chronic-diarrhea
#4
Bethânia Ferreira Bastos, Beatriz Brener, Mariana Alves de Figueiredo, Daniela Leles, Flavya Mendes-de-Almeida
Case series summary: Chronic diarrhea is a common and recurring problem in feline medicine. Intestinal trichomonads have been reported as causative agents of diarrhea in cats. While Pentatrichomonas hominis is considered commensal, Tritrichomonas foetus has been found to cause feline large bowel diarrhea in cats. In our report, two young cats infected with the feline leukemia virus (FeLV) and presenting with chronic diarrhea were identified as having trichomonads in their feces, based on direct examination and fecal culture...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29788832/feline-injection-site-sarcoma-immunohistochemical-characteristics
#5
Carolina S Carneiro, Genilson F de Queiroz, Ana Cbcf Pinto, Maria Lz Dagli, Julia M Matera
Objectives Feline injection site sarcoma (FISS) is a rapid growing locally aggressive tumor with a low metastatic rate. Its histologic features are clearly defined, but there are few studies regarding its immunohistochemical characteristics. The present study investigated the immunohistochemical characteristics of 21 cases of FISS. Methods FISSs from 12 male and nine female cats, 20 mixed-breed and one Siamese, were included in the study. After histopathological diagnosis, additional histologic sections were immunostained for vimentin, cytokeratin, desmin, S100 protein, viral feline leukemia virus (FeLV) particles, cyclooxygenase 2 (COX-2) and c-KIT...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29642384/tracking-the-continuous-evolutionary-processes-of-an-endogenous-retrovirus-of-the-domestic-cat-erv-dc
#6
REVIEW
Junna Kawasaki, Kazuo Nishigaki
An endogenous retrovirus (ERV) is a remnant of an ancient retroviral infection in the host genome. Although most ERVs have lost their viral productivity, a few ERVs retain their replication capacity. In addition, partially inactivated ERVs can present a potential risk to the host via their encoded virulence factors or the generation of novel viruses by viral recombination. ERVs can also eventually acquire a biological function, and this ability has been a driving force of host evolution. Therefore, the presence of an ERV can be harmful or beneficial to the host...
April 6, 2018: Viruses
https://www.readbyqxmd.com/read/29554969/infection-by-mycoplasma-spp-feline-immunodeficiency-virus-and-feline-leukemia-virus-in-cats-from-an-area-endemic-for-visceral-leishmaniasis
#7
Mary Marcondes, Karina Y Hirata, Juliana P Vides, Ludmila S V Sobrinho, Jaqueline S Azevedo, Thállitha S W J Vieira, Rafael F C Vieira
BACKGROUND: Visceral leishmaniasis (VL) has been increasingly recognized in cats living in areas endemic for the disease. Co-infection with Leishmania infantum and other infectious agents is well established in dogs. However, for cats, data on co-infections with L. infantum and other infectious agents are still sparse. The aim of this study was to identify the prevalence of vector-borne pathogens, Mycoplasma spp., feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) in cats from an area endemic for VL in southeastern Brazil...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29532854/flvcr1-promotes-the-proliferation-and-tumorigenicity-of-synovial-sarcoma-through-inhibiting-apoptosis-and-autophagy
#8
Changliang Peng, Yan Song, Wei Chen, Xiaoying Wang, Xiaoli Liu, Fang Wang, Dongjin Wu, Shengzhong Ma, Xiuwen Wang, Chunzheng Gao
Feline leukemia virus subgroup C receptor 1 (FLVCR1) has been reported to have a crucial role in variety of biological processes, including cell proliferation, cell death, apoptosis, oxidative stress response, cellular differentiation and metabolism. However, little is known about its role in synovial sarcoma (SS). In the current study, FLVCR1 expression was analyzed in two SS cell lines (SW982 and HS-SY-II), and in eight SS tissues and paired adjacent non-tumor tissues using reverse transcription-quantitative polymerase chain reaction, western blot analysis and immunohistochemistry...
March 8, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29487747/extranodal-non-b-non-t-cell-lymphoma-with-bilateral-tympanic-bulla-involvement-in-a-cat
#9
Austin T Kerns, Kelsey A Brakel, Christopher Premanandan, Ashlie Saffire, Sarah A Moore
Case summary: A 9-year-old spayed female domestic shorthair cat with clinical signs suggestive of chronic recurrent otitis media and recent seizures was presented with multifocal nervous system disease, including bilateral central and/or peripheral vestibular, cerebellar and forebrain deficits. Prior to presentation, there was inadequate improvement after 6 weeks of treatment for bilateral middle ear effusion from which a highly susceptible Staphylococcus species was cultured. This was followed by the development of seizures...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29456553/silencing-of-iron-and-heme-related-genes-revealed-a-paramount-role-of-iron-in-the-physiology-of-the-hematophagous-vector-rhodnius-prolixus
#10
Ana B Walter-Nuno, Mabel L Taracena, Rafael D Mesquita, Pedro L Oliveira, Gabriela O Paiva-Silva
Iron is an essential element for most organisms However, free iron and heme, its complex with protoporphyrin IX, can be extremely cytotoxic, due to the production of reactive oxygen species, eventually leading to oxidative stress. Thus, eukaryotic cells control iron availability by regulating its transport, storage and excretion as well as the biosynthesis and degradation of heme. In the genome of Rhodnius prolixus , the vector of Chagas disease, we identified 36 genes related to iron and heme metabolism We performed a comprehensive analysis of these genes, including identification of homologous genes described in other insect genomes...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29406082/survival-time-and-effect-of-selected-predictor-variables-on-survival-in-owned-pet-cats-seropositive-for-feline-immunodeficiency-and-leukemia-virus-attending-a-referral-clinic-in-northern-italy
#11
Eva Spada, Roberta Perego, Elena Assunta Sgamma, Daniela Proverbio
Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are among the most important feline infectious diseases worldwide. This retrospective study investigated survival times and effects of selected predictor factors on survival time in a population of owned pet cats in Northern Italy testing positive for the presence of FIV antibodies and FeLV antigen. One hundred and three retrovirus-seropositive cats, 53 FIV-seropositive cats, 40 FeLV-seropositive cats, and 10 FIV+FeLV-seropositive cats were included in the study...
February 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29386166/-feline-leukemia-virus-infection-importance-and-current-situation-in-switzerland
#12
R Hofmann-Lehmann, E Gönczi, B Riond, M Meli, B Willi, J Howard, D Schaarschmidt-Kiener, W Regli, U Gilli, F Boretti
Feline leukemia virus (FeLV) leads to fatal disease in cats with progressive infection. The aim of this study was to determine the importance of FeLV infection in Switzerland and make a comparison with previous studies. Of 881 blood samples taken from cats living in Switzerland (minimum of 20 samples per Canton), 47 samples were provirus-positive (5.3%; 95% confidence interval (CI) 3.9-7.0%) and 18 samples were antigen-positive (2%; 95% CI 1.2-3.2%). Together with data previously collected in similar studies, these findings demonstrated a decrease in prevalence between 1997 and 2003 followed by a relative constant low prevalence thereafter...
February 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29353423/polymerase-chain-reaction-based-detection-of-myc-transduction-in-feline-leukemia-virus-infected-cats
#13
Ryosuke Sumi, Ariko Miyake, Taiji Endo, Yoshiharu Ohsato, Minh Ha Ngo, Kazuo Nishigaki
Feline lymphomas are associated with the transduction and activation of cellular proto-oncogenes, such as c-myc, by feline leukemia virus (FeLV). We describe a polymerase chain reaction assay for detection of myc transduction usable in clinical diagnosis. The assay targets c-myc exons 2 and 3, which together result in a FeLV-specific fusion gene following c-myc transduction. When this assay was conducted on FeLV-infected feline tissues submitted for clinical diagnosis of tumors, myc transduction was detected in 14% of T-cell lymphoma/leukemias...
April 2018: Archives of Virology
https://www.readbyqxmd.com/read/29320424/a-retrospective-examination-of-feline-leukemia-subgroup-characterization-viral-interference-assays-to-deep-sequencing
#14
REVIEW
Elliott S Chiu, Edward A Hoover, Sue VandeWoude
Feline leukemia virus (FeLV) was the first feline retrovirus discovered, and is associated with multiple fatal disease syndromes in cats, including lymphoma. The original research conducted on FeLV employed classical virological techniques. As methods have evolved to allow FeLV genetic characterization, investigators have continued to unravel the molecular pathology associated with this fascinating agent. In this review, we discuss how FeLV classification, transmission, and disease-inducing potential have been defined sequentially by viral interference assays, Sanger sequencing, PCR, and next-generation sequencing...
January 10, 2018: Viruses
https://www.readbyqxmd.com/read/29318027/diagnostic-performances-of-two-rapid-tests-for-detection-of-feline-leukemia-virus-antigen-in-sera-of-experimentally-feline-leukemia-virus-infected-cats
#15
Matthew R Krecic, Sridhar Velineni, Patrick Meeus, Huihao Fan, Michael Loenser
Objectives: The objective of this study was to compare the diagnostic sensitivities and specificities of WITNESS FeLV-FIV (Zoetis) and SNAP FIV/FeLV Combo Test (IDEXX) for the detection of FeLV p27 antigen in the sera of experimentally feline leukemia virus (FeLV)-infected cats. Methods: Diagnostic sensitivities of WITNESS and SNAP were determined through testing of 47 serum samples collected from cats day 56 post-experimental infection with a virulent FeLV Rickard strain...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29197389/foamy-virus-zoonotic-infections
#16
Delia M Pinto-Santini, Carolyn R Stenbak, Maxine L Linial
BACKGROUND: Foamy viruses (FV) are ancient complex retroviruses that differ from orthoretroviruses such as human immunodeficiency virus (HIV) and murine leukemia virus (MLV) and comprise a distinct subfamily of retroviruses, the Spumaretrovirinae. FV are ubiquitous in their natural hosts, which include cows, cats, and nonhuman primates (NHP). FV are transmitted mainly through saliva and appear nonpathogenic by themselves, but they may increase morbidity of other pathogens in coinfections...
December 2, 2017: Retrovirology
https://www.readbyqxmd.com/read/29192808/a-splice-site-variant-in-flvcr1-produces-retinitis-pigmentosa-without-posterior-column-ataxia
#17
Imran H Yusuf, Morag E Shanks, Penny Clouston, Robert E MacLaren
FLVCR1 (feline leukemia virus subgroup c receptor 1) is a transmembrane protein involved in the trafficking of intracellular heme. Homozygous variants in FLVCR1 have been described in association with a clinical syndrome of posterior column ataxia with retinitis pigmentosa (PCARP). Here, we describe a patient with non-syndromic retinitis pigmentosa homozygous for a splice-site variant in FLVCR1 (c.1092 + 5G>A) without evidence of posterior column ataxia or cerebellar degeneration. We suggest an association between intronic splice-site variants in FLVCR1 and the absence of posterior column degeneration and suggest a hypothesis to explain this observation...
April 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29149857/putative-progressive-and-abortive-feline-leukemia-virus-infection-outcomes-in-captive-jaguarundis-puma-yagouaroundi
#18
Claudia Filoni, A Katrin Helfer-Hungerbuehler, José Luiz Catão-Dias, Mara Cristina Marques, Luciana Neves Torres, Manfred Reinacher, Regina Hofmann-Lehmann
BACKGROUND: Feline leukemia virus (FeLV) is an exogenous gammaretrovirus of domestic cats (Felis catus) and some wild felids. The outcomes of FeLV infection in domestic cats vary according to host susceptibility, virus strain, and infectious challenge dose. Jaguarundis (Puma yagouaroundi) are small wild felids from South and Central America. We previously reported on FeLV infections in jaguarundis. We hypothesized here that the outcomes of FeLV infection in P. yagouaroundi mimic those observed in domestic cats...
November 17, 2017: Virology Journal
https://www.readbyqxmd.com/read/29056675/felis-catus-gammaherpesvirus-1-dnaemia-in-whole-blood-from-therapeutically-immunosuppressed-or-retrovirus-infected-cats
#19
Alicia J McLuckie, Vanessa R Barrs, Bethany Wilson, Mark E Westman, Julia A Beatty
Gammaherpesviruses are major co-pathogens of human immunodeficiency virus (HIV) infection, making the interactions between feline immunodeficiency virus (FIV) and Felis catus gammaherpesvirus 1 (FcaGHV1) pertinent to both human and veterinary medical research. FIV-infected cats are at increased risk of FcaGHV1 DNAemia and consistently harbor higher FcaGHV1 loads than FIV-uninfected cats. Whether immune deficiencies unrelated to FIV are associated with similar risks is unknown. Using whole blood FcaGHV1 qPCR, we found no difference in the frequency of DNAemia or DNA load in therapeutically immunosuppressed (P1, n = 18) or feline leukemia virus (FeLV)-infected (P2, n = 57) patients compared with age- and sex-matched controls (C1, n = 58; C2, n = 57)...
March 14, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/28957693/interferon-omega-current-status-in-clinical-applications
#20
REVIEW
Shi-Fang Li, Fu-Rong Zhao, Jun-Jun Shao, Yin-Li Xie, Hui-Yun Chang, Yong-Guang Zhang
Since 1985, interferon (IFN)-ω, a type I IFN, has been identified in many animals, but not canines and mice. It has been demonstrated to have antiviral, anti-proliferation, and antitumor activities that are similar to those of IFN-α. To date, IFN-ω has been explored as a treatment option for some diseases or viral infections in humans and other animals. Studies have revealed that human IFN-ω displays antitumor activities in some models of human cancer cells and that it can be used to diagnose some diseases...
September 25, 2017: International Immunopharmacology
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