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Wolfgang Hemmer, Christoph Klug, Ines Swoboda
Allergy to poultry meat is rare and affects both children and adults. The prevalence of poultry meat allergy is unknown, but presumably is similar to that of red meat allergy. There is no close relationship between allergy to poultry meat and allergy to red meat. Poultry meat allergy may present as primary (genuine) food allergy or as secondary food allergy resulting from cross-reactivity. Secondary poultry meat allergy may arise in the context of bird-egg-syndrome, which is due to sensitization to serum albumins present in many tissues including muscle tissue and egg yolk (Gal d 5)...
2016: Allergo Journal International
Najmeh Dabbagh, Ahmadreza Soroosh, Zhamak Khorgami, Abolfazl Shojaeifard, Mehdi Jafari, Ali Ghorbani Abdehgah, Hossein Mahmudzade
BACKGROUND: Surgical technique using small-diameter instruments and single-incision laparoscopy are two new options for less invasive laparoscopic cholecystectomy (LC). In this study, we have compared mini-LC (MLC) with single-incision LC (SILC). MATERIALS AND METHODS: This study is a randomized clinical trial conducted on the patients diagnosed with symptomatic cholelithiasis who underwent LC. Forty patients were randomized to two equal groups of MLC and SILC. They were compared in terms of demographic data, operation time, and surgical complications...
December 2015: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Todd E Gillis, Jordan M Klaiman, Andrew Foster, Mathew J Platt, Jason S Huber, Melissa Y Corso, Jeremy A Simpson
Dyspnea and reduced exercise capacity, caused, in part, by respiratory muscle dysfunction, are common symptoms in patients with heart failure (HF). However, the etiology of diaphragmatic dysfunction has not been identified. To investigate the effects of HF on diaphragmatic function, models of HF were surgically induced in CD-1 mice by transverse aortic constriction (TAC) and acute myocardial infarction (AMI), respectively. Assessment of myocardial function, isolated diaphragmatic strip function, myofilament force-pCa relationship, and phosphorylation status of myofilament proteins was performed at either 2 or 18 wk postsurgery...
March 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Mareomi Hamada, Yuji Shigematsu, Takashi Ohtani, Shuntaro Ikeda
BACKGROUND: To better understand the evolution of typical hypertrophic cardiomyopathy (HCM) to heart failure (HF), we investigated the relationship between serum biochemical abnormalities and changes in left ventricular (LV) remodeling. METHODS AND RESULTS: Seventy-seven HCM patients were followed for 20 years. Creatine kinase (CK), CK-MB, lactate dehydrogenase (LDH), LDH-1, troponin T and myosin light chain-1 (MLC-1) were measured. Abnormal CK-MB elevation was observed in 64% of HCM patients...
2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Jiayuan Peng, Zhen Zhang, Jiazhou Wang, Jiang Xie, Junchao Chen, Weigang Hu
GafChromic RTQA2 film is a type of radiochromic film designed for light field and radiation field alignment. The aim of this study is to extend the application of RTQA2 film to the measurement of patient specific quality assurance (QA) fields as a 2D relative dosimeter.Pre-irradiated and post-irradiated RTQA2 films were scanned in reflection mode using a flatbed scanner. A plan-based calibration (PBC) method utilized the mapping information of the calculated dose image and film grayscale image to create a dose versus pixel value calibration model...
October 7, 2015: Physics in Medicine and Biology
Zhen Li, Xiao-bai Liu, Yun-hui Liu, Yi-xue Xue, Jing Liu, Hao Teng, Zhuo Xi, Yi-long Yao
Previous studies have demonstrated that low-dose endothelial monocyte-activating polypeptide-II (EMAP-II) induces blood-tumor barrier (BTB) hyperpermeability via both paracellular and transcellular pathways. In a recent study, we revealed that cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)-dependent signaling pathway is involved in EMAP-II-induced BTB hyperpermeability. This study further investigated the exact mechanisms through which the cAMP/PKA-dependent signaling pathway affects EMAP-II-induced BTB hyperpermeability...
February 2016: Journal of Molecular Neuroscience: MN
Timothy P Szczykutowicz, James Hermus, Mark Geurts, Jennifer Smilowitz
The multi-leaf collimator (MLC) assembly present on TomoTherapy (Accuray, Madison WI) radiation therapy (RT) and mega voltage CT machines is well suited to perform fluence field modulated CT (FFMCT). In addition, there is a demand in the RT environment for FFMCT imaging techniques, specifically volume of interest (VOI) imaging. A clinical TomoTherapy machine was programmed to perform VOI. Four different size ROIs were placed at varying distances from isocenter. Projections intersecting the VOI received 'full dose' while those not intersecting the VOI received 30% of the dose (i...
September 21, 2015: Physics in Medicine and Biology
Yingqiu Liu, Jung-Min Park, Kyung-Hwa Chang, Young-Won Chin, Moo-Yeol Lee
α- and γ-mangostin are natural xanthones isolated from mangosteen (Garcinia mangostana) and the major constituents responsible for the plant's diverse biological activities. In this study, the effects of α- and γ-mangostin on platelets were investigated based on their possible antiplatelet activity. Treatment of isolated platelets with α-mangostin resulted in attenuation of platelet aggregatory response to collagen, thrombin or ADP. Such antiaggregatory effects were concentration-dependent in ranges of 1-10 μM...
October 5, 2015: Chemico-biological Interactions
S Wang, H Duan, Y Zhang, F Q Sun
Adenomyosis (ADS) is a common estrogen-dependent gynecological disease with unknown etiology. The RhoA/Rho-kinase (ROCK) signaling pathway is involved in various cellular functions, including migration, proliferation, and smooth muscle contraction. Here we examined the potential role of this pathway in junctional zone (JZ) contraction in women with and without ADS. We demonstrated that in the normal JZ, RhoA and ROCK-I messenger RNA (mRNA) and protein expression was significantly higher in the proliferative phase of the menstrual cycle than in the secretory phase...
March 2016: Reproductive Sciences
Steffi Kantz, Matthias Söhn, Almut Troeller, Michael Reiner, Helmut Weingandt, Markus Alber, Claus Belka, Ute Ganswindt
PURPOSE: The impact of multileaf collimator (MLC) design and IMRT technique on plan quality and delivery improvements for head-and-neck and meningioma patients is compared in a planning study. MATERIAL AND METHODS: Ten previously treated patients (5 head-and-neck, 5 meningioma) were re-planned for step-and-shoot IMRT (ssIMRT), sliding window IMRT (dMLC) and VMAT using the MLCi2 without (-) and with (+) interdigitation and the Agility-MLC attached to an Elekta 6MV linac...
2015: Radiation Oncology
Ya-Ting Cheng, Dong-Feng Yeih, Shu-Man Liang, Chia-Ying Chien, Yen-Ling Yu, Bor-Sheng Ko, Yee-Jee Jan, Cheng-Chin Kuo, Li-Ying Sung, Song-Kun Shyue, Ming-Fong Chen, Shaw-Fang Yet, Kenneth K Wu, Jun-Yang Liou
BACKGROUND: Rho-associated kinase (ROCK) plays an important role in maintaining embryonic stem (ES) cell pluripotency. To determine whether ROCK is involved in ES cell differentiation into cardiac and hematopoietic lineages, we evaluated the effect of ROCK inhibitors, Y-27632 and fasudil on murine ES and induced pluripotent stem (iPS) cell differentiation. METHODS: Gene expression levels were determined by real-time PCR, Western blot analysis and immunofluorescent confocal microscopy...
December 15, 2015: International Journal of Cardiology
Jie Du, Yunzi Chen, Yongyan Shi, Tianjing Liu, Yong Cao, Yue Tang, Xin Ge, Hongguang Nie, Changqing Zheng, Yan Chun Li
BACKGROUND: The myosin light chain kinase (MLCK) pathway controls intestinal epithelial barrier permeability by regulating the tight junction. 1,25-dihydroxyvitamin D (1,25(OH)2D3)-vitamin D receptor (VDR) signaling protects the epithelial barrier, but the molecular mechanism is incompletely understood. METHODS: MLCK activation and barrier permeability were studied using monolayers of HCT116, Caco-2, and SW480 cells treated with tissue necrosis factor α with or without 1,25(OH)2D3...
November 2015: Inflammatory Bowel Diseases
Leela S Panchakarla, Gal Radovsky, Lothar Houben, Ronit Popovitz-Biro, Rafal E Dunin-Borkowski, Reshef Tenne
Nanotubes that are formed from layered materials have emerged to be exciting one-dimensional materials in the last two decades due to their remarkable structures and properties. Misfit layered compounds (MLC) can be produced from alternating assemblies of two different molecular slabs with different periodicities with the general formula [(MX)1+x]m[TX2]n (or more simply MS-TS2), where M is Sn, Pb, Bi, Sb, rare earths, T is Sn, Nb, Ta, Ti, V, Cr, and so on, and X is S, Se. The presence of misfit stresses between adjacent layers in MLC provides a driving force for curling of the layers that acts in addition to the elimination of dangling bonds...
November 6, 2014: Journal of Physical Chemistry Letters
Joanne Kurtzberg, Susan Buntz, Tracy Gentry, Pamela Noeldner, April Ozamiz, Benjamin Rusche, Robert W Storms, Amy Wollish, David A Wenger, Andrew E Balber
BACKGROUND AIMS: Cord blood (CB) transplantation slows neurodegeneration during certain inherited metabolic diseases. However, the number of donor cells in the brain of patients does not appear to be sufficient to provide benefit until several months after transplant. We developed the cell product DUOC-01 to provide therapeutic effects in the early post-transplant period. METHODS: DUOC-01 cultures initiated from banked CB units were characterized by use of time-lapse photomicroscopy during the 21-day manufacturing process...
September 2015: Cytotherapy
A Pichandi, K M Ganesh, A Jerrin, K Balaji, P S Sridhar, A Surega
Radiotherapy planning, delivery and junction dose verification remain exigent for Cranio Spinal Irradiation (CSI) in medulloblastoma patients. This study aims to evaluate high precision techniques such as Intensity Modulated Radiation Therapy (IMRT), Rapid Arc Therapy (RA) with and without flattening filter (FF) on the basis of dosimetric analysis. Five patients treated with jagged junction Intensity Modulated RadioTherapy (IMRT) using dynamic Multi Leaf Collimators (MLC) were randomly selected for this retrospective study...
August 2015: Technology in Cancer Research & Treatment
Shan-Wen Chen, Jing Zhu, Shuai Zuo, Jun-Ling Zhang, Zi-Yi Chen, Guo-Wei Chen, Xin Wang, Yi-Sheng Pan, Yu-Cun Liu, Peng-Yuan Wang
BACKGROUND AND AIM: Studies have verified the protective effect of Hydrogen Sulfide (H2S) on gastric ulcer and ulcerative colitis, but the mechanisms are not fully illustrated. In this study, the possible protective effect of H2S on TNF-α/IFN-γ induced barrier dysfunction was investigated in Caco-2 cell monolayers. METHOD: The barrier function of Caco-2 monolayers was evaluated by measuring trans-epithelial electrical resistance (TEER) and FITC-Dextran 4 kDa (FD-4) trans-membrane flux...
October 2015: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Miao Zhang, Lihua Wang, Rui Guo, Sheng Liang, Xufeng Jiang, Min Zhang, Biao Li
BACKGROUND: Our study aimed to demonstrate the feasibility of using the sodium/iodide symporter (NIS) to monitor vascular endothelial growth factor (VEGF165) expression in vivo. METHODS: We constructed a recombinant lentivirus plasmid with the MLC-2v promoter driving the sodium/iodide symporter (NIS) reporter gene linked to the VEGF165 gene. Expression of NIS and VEGF gene were identified by Western blot. On days 2 and 54, 99mTc-MIBI imaging was used to evaluate changes in myocardial ischemia...
2015: PloS One
Shanmuga V Subramanian, Vellaiyan Subramani, Shanmugam Thirumalai Swamy, Arun Gandhi, Srinivas Chilukuri, Murugesan Kathirvel
The aim of this study is to assess the suitability of 5 mm millennium multileaf collimator (MMLC) for volumetric-modulated arc therapy (VMAT)-based lung stereotactic body radiotherapy (SBRT). Thirty lung SBRT patient treatment plans along with their planning target volumes (ranging from 2.01 cc to 150.11 cc) were transferred to an inhomogeneous lung phantom and retrospectively planned using VMAT technique, along with the high definition multileaf collimator (HDMLC) and MMLC systems. The plans were evaluated using Radiation Therapy Oncology Group (RTOG-0813) treatment planning criteria for target coverage, normal tissue sparing, and treatment efficiency for both the MMLC and HDMLC systems using flat and flattening filter-free (FFF) photon beams...
July 8, 2015: Journal of Applied Clinical Medical Physics
Weiguang Yao, Jonathan B Farr
Individual QA for IMRT/VMAT plans is required by protocols. Sometimes plans cannot pass the institute's QA criteria. For the Eclipse treatment planning system (TPS) with rounded leaf-end multileaf collimator (MLC), one practical way to improve the agreement of planned and delivered doses is to tune the value of dosimetric leaf gap (DLG) in the TPS from the measured DLG. We propose that this step may be necessary due to the complexity of the MLC system, including dosimetry of small fields and the tongue-and-groove (T&G) effects, and report our use of test fields to obtain linac-specific optimal DLGs in TPSs...
July 8, 2015: Journal of Applied Clinical Medical Physics
Ning Wen, Haisen Li, Kwang Song, Karen Chin-Snyder, Yujiao Qin, Jinkoo Kim, Maria Bellon, Misbah Gulam, Stephen Gardner, Anthony Doemer, Suneetha Devpura, James Gordon, Indrin Chetty, Farzan Siddiqui, Munther Ajlouni, Robert Pompa, Zane Hammoud, Michael Simoff, Steven Kalkanis, Benjamin Movsas, M Salim Siddiqui
The purpose of this study is to characterize the dosimetric properties and accuracy of a novel treatment platform (Edge radiosurgery system) for localizing and treating patients with frameless, image-guided stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Initial measurements of various components of the system, such as a comprehensive assessment of the dosimetric properties of the flattening filter-free (FFF) beams for both high definition (HD120) MLC and conical cone-based treatment, positioning accuracy and beam attenuation of a six degree of freedom (6DoF) couch, treatment head leakage test, and integrated end-to-end accuracy tests, have been performed...
July 8, 2015: Journal of Applied Clinical Medical Physics
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