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https://www.readbyqxmd.com/read/27923027/corrigendum-melanoma-exosomes-educate-bone-marrow-progenitor-cells-toward-a-pro-metastatic-phenotype-through-met
#1
Héctor Peinado, Maša Alecˇković, Simon Lavotshkin, Irina Matei, Bruno Costa-Silva, Gema Moreno-Bueno, Marta Hergueta-Redondo, Caitlin Williams, Guillermo García-Santos, Cyrus M Ghajar, Ayuko Nitadori-Hoshino, Caitlin Hoffman, Karen Badal, Benjamin A Garcia, Margaret K Callahan, Jianda Yuan, Vilma R Martins, Johan Skog, Rosandra N Kaplan, Mary S Brady, Jedd D Wolchok, Paul B Chapman, Yibin Kang, Jacqueline Bromberg, David Lyden
No abstract text is available yet for this article.
December 6, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27921006/survival-and-control-prognosticators-of-recurrent-gynecological-malignancies-of-the-pelvis-and-para-aortic-region-treated-with-stereotactic-body-radiation-therapy
#2
Shaakir Hasan, Anthony Ricco, Kaylette Jenkins, Rachelle Lanciano, Alexandra Hanlon, John Lamond, Jun Yang, Jing Feng, Michael Good, Joel Noumoff, Luther Brady
PURPOSE: To define prognostic factors associated with improved survival and local control (LC) for gynecologic cancer recurrences limited to the pelvis and para-aortic (PA) region using stereotactic body radiation therapy (SBRT). METHODS: Between 2/2008 and 7/2014, 30 women (35 targets) with pelvic or PA recurrence of endometrioid (n = 12), cervical (n = 11), ovarian (n = 3), uterine-serous (n = 2), or carcinosarcoma (n = 2) cancer were treated with SBRT...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27916601/gaucher-disease-circa-2016-progress-and-ongoing-challenges
#3
REVIEW
Pramod K Mistry, Grisel Lopez, Raphael Schiffmann, Norman W Barton, Neal J Weinreb, Ellen Sidransky
Over the past decades, tremendous progress has been made in the field of Gaucher disease, the inherited deficiency of the lysosomal enzyme glucocerebrosidase. Many of the colossal achievements took place during the course of the sixty-year tenure of Dr. Roscoe Brady at the National Institutes of Health. These include the recognition of the enzymatic defect involved, the isolation and characterization of the protein, the localization and characterization of the gene and its nearby pseudogene, as well as the identification of the first mutant alleles in patients...
November 17, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27913528/mutations-in-mpns-prognostic-implications-window-to-biology-and-impact-on-treatment-decisions
#4
Jamile M Shammo, Brady L Stein
The last decade has witnessed tremendous scientific advances, ushered in by the JAK2 V617F discovery, contributing to enhanced diagnostic capability and understanding of the biology of myeloproliferative neoplasms (MPNs). Discovery of the calreticulin mutations filled a diagnostic gap; more recent work sheds light on its contribution to disease pathogenesis, and prognosis. Recent studies have also identified novel JAK2 and MPL mutations in patients with essential thrombocythemia and myelofibrosis (MF). Especially in MF, the driver mutational profile has prognostic implications, with additive contributions from the acquisition of additional somatic mutations...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27912925/cardiac-arrest-in-pediatric-patients-receiving-azithromycin
#5
Santiago O Valdés, Jeffrey J Kim, Mary C Niu, Caridad M de la Uz, Christina Y Miyake, Brady S Moffett
OBJECTIVE: To compare outcomes of pediatric patients treated with azithromycin compared with penicillin or cephalosporin. We hypothesized that azithromycin use would not be associated with increased cardiac mortality in the pediatric population. STUDY DESIGN: Retrospective cohort study from the Pediatric Health Information System database between 2008 and 2012. Patients <19 years of age with a principal diagnosis of community-acquired pneumonia who received an antibiotic were included...
November 29, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27912146/inosine-acedoben-dimepranol-promotes-an-early-and-sustained-increase-in-the-natural-killer-cell-component-of-circulating-lymphocytes-a-clinical-trial-supporting-anti-viral-indications
#6
S Rumel Ahmed, Amy S Newman, James O'Daly, Sean Duffy, Gillian Grafton, Catherine A Brady, S John Curnow, Nicholas M Barnes, John Gordon
Inosine Acedoben Dimepranol (IAD), licensed for the treatment of cell-mediated immune deficiencies associated with viral infections, has been reported to impact a variety of immune parameters both in vitro and in vivo. Here we report the results from a clinical trial where multiple lymphocyte subsets - CD19+ B cells, CD3+ T cells, CD4+ T-helper cells, FoxP3(hi)/CD25(hi)/CD127(lo) regulatory T cells (Tregs), CD3-/CD56+ NK cells, and CD3+/CD56+ NKT cells - were, together with serum immunoglobulins and IgG subclasses, followed during 14days of IAD administration to ten healthy volunteers; these selected from 27 individuals pre-screened in vitro for their capacity to respond to IAD as gauged by increases in the percentage of Treg and/or NKT cells arising in PHA-stimulated cultures...
November 29, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27911822/urban-park-soil-microbiomes-are-a-rich-reservoir-of-natural-product-biosynthetic-diversity
#7
Zachary Charlop-Powers, Clara C Pregitzer, Christophe Lemetre, Melinda A Ternei, Jeffrey Maniko, Bradley M Hover, Paula Y Calle, Krista L McGuire, Jeanne Garbarino, Helen M Forgione, Sarah Charlop-Powers, Sean F Brady
Numerous therapeutically relevant small molecules have been identified from the screening of natural products (NPs) produced by environmental bacteria. These discovery efforts have principally focused on culturing bacteria from natural environments rich in biodiversity. We sought to assess the biosynthetic capacity of urban soil environments using a phylogenetic analysis of conserved NP biosynthetic genes amplified directly from DNA isolated from New York City park soils. By sequencing genes involved in the biosynthesis of nonribosomal peptides and polyketides, we found that urban park soil microbiomes are both rich in biosynthetic diversity and distinct from nonurban samples in their biosynthetic gene composition...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27909103/habenula-induced-inhibition-of-midbrain-dopamine-neurons-is-diminished-by-lesions-of-the-rostromedial-tegmental-nucleus
#8
P Leon Brown, Heather Palacorolla, Dana Brady, Katelyn Riegger, Greg I Elmer, Paul D Shepard
: Neurons in the lateral habenula (LHb) are transiently activated by aversive events and have been implicated in associative learning. Functional changes associated with tonic and phasic activation of the LHb are often attributed to a corresponding inhibition of midbrain dopamine (DA) neurons. Activation of GABAergic neurons in the rostromedial tegmental nucleus (RMTg), a region that receives dense projections from the LHb and projects strongly to midbrain monoaminergic nuclei, is believed to underlie the transient inhibition of DA neurons attributed to activation of the LHb...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27908943/planning-for-deactivation-of-implantable-cardioverter-defibrillators-at-the-end-of-life-in-patients-with-heart-failure
#9
Destiny R Brady
Implantable cardioverter defibrillators (ICDs) may be burdensome in end-stage heart failure. At the end of life, as many as one-fifth to one-third of patients experience an ICD shock. Critical care nurses should be aware of the potential burden of these shocks at the end of life as well as the ethics and organizational policies surrounding ICD deactivation. This literature review examines the issues surrounding ICD therapy at the end of life. Based on this author's findings, recommendations for discussing and implementing ICD deactivation are offered...
December 2016: Critical Care Nurse
https://www.readbyqxmd.com/read/27905182/optimizing-combination-dabrafenib-and-trametinib-therapy-in-braf-mutation-positive-advanced-melanoma-patients-guidelines-from-australian-melanoma-medical-oncologists
#10
Victoria Atkinson, Georgina V Long, Alexander M Menzies, Grant McArthur, Matteo S Carlino, Michael Millward, Rachel Roberts-Thomson, Benjamin Brady, Richard Kefford, Andrew Haydon, Jonathan Cebon
BRAF mutations occur commonly in metastatic melanomas and inhibition of mutant BRAF and the downstream kinase MEK results in rapid tumor regression and prolonged survival in patients. Combined therapy with BRAF and MEK inhibition improves response rate, progression free survival and overall survival compared with single agent BRAF inhibition, and reduces the skin toxicity that is seen with BRAF inhibitor monotherapy. However, this combination is associated with an increase in other toxicities, particularly drug-related pyrexia, which affects approximately 50% of patients treated with dabrafenib and trametinib (CombiDT)...
December 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27902294/actinocrinis-puniceicyclus-gen-nov-sp-nov-a-novel-actinobacterium-isolated-from-an-acidic-spring-in-kootenay-national-park-canada
#11
Joong-Jae Kim, Colbran E Marjerrison, Sabrina L Cornish Shartau, Allyson L Brady, Christine E Sharp, W Irene C Rijpstra, Jaap S Sinninghe Damsté, Peter Schumann, Stephen E Grasby, Peter F Dunfield
An aerobic, mildly acidophilic actinobacterium was isolated from the Ochre Beds bog in Kootenay National Park, Canada. Cells of isolate OB1T were Gram-positive, non-motile, pink-to purple-pigmented filaments. The pH range for growth was 3.5 - 6.5 (optimum 5.5), and the temperature range was 13-37 oC. The major cellular fatty acids were 16:0 iso (28.5 %), 15:0 iso (14.6 %) and 15:0 anteiso (14.3 %), and the major polar lipid was phosphohexose. The major quinone was menaquinone-11 (MK-11) and the peptidoglycan type was A1γ...
November 16, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27894624/female-with-palpitations-and-weakness
#12
William J Brady, Amal Mattu, Justin O Cook, Jeffrey Tabas
No abstract text is available yet for this article.
December 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27894623/female-with-chest-pain-and-nausea
#13
William J Brady, Amal Mattu, Jeffrey Tabas
No abstract text is available yet for this article.
December 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27894507/do-simple-beside-lung-function-tests-predict-morbidity-after-rib-fractures
#14
Christopher A Butts, John J Brady, Sara Wilhelm, Laura Castor, Alicia Sherwood, Abby McCall, John Patch, Pamela Jones, Vicente Cortes, Adrian W Ong
BACKGROUND: We evaluated if incentive spirometry volume (ISV) and peak expiratory flow rate (PEFR) could predict acute respiratory failure (ARF) in patients with rib fractures. METHODS: Normotensive, co-operative patients were enrolled prospectively. ISV and PEFR were measured on admission, at 24 h and at 48 h by taking the best of three readings each time. The primary outcome, ARF, was defined as requiring invasive or noninvasive positive pressure ventilation...
November 19, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27889945/social-media-in-colorectal-surgery
#15
Steven D Wexner, Andrea M Petrucci, Richard R Brady, Marie Ennis-O'Connor, Edward Fitzgerald, Julio Mayol
Social media engagement in healthcare continues to expand. For members of the colorectal community, social media has already made a significant impact on practice, education and patient care. The applications are unique such that they provide a platform for instant communication and information sharing with other users worldwide. The purpose of this article is to provide an overview of how social media has the potential to change clinical practice, training, research and patient care in colorectal surgery...
November 27, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27889268/evaluating-surgical-management-and-outcomes-of-colovaginal-fistulas
#16
Yuxiang Wen, Alison R Althans, Justin T Brady, Eslam M G Dosokey, Dongjin Choi, Madhuri Nishtala, Conor P Delaney, Scott R Steele
BACKGROUND: Colovaginal fistula is a rare condition associated with significant morbidity. The literature characterizing colovaginal fistula repair is sparse. We present our institution's experience treating colovaginal fistulas. METHODS: A retrospective review of all patients surgically treated for colovaginal fistula between 2005 and 2015 was performed. Patient demographics, intra-operative details, and post-operative outcomes were reviewed. RESULTS: We identified 27 patients with a mean age of 71 (±13) and BMI of 30 (±9)...
November 14, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27888236/schlafen-1-causes-a-cell-cycle-arrest-by-inhibiting-induction-of-cyclin-d1
#17
Gareth Brady, Louise Boggan, Andrew Bowie, Luke A J O'Neill
No abstract text is available yet for this article.
November 25, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27886575/an-evaluation-of-the-appropriateness-and-effectiveness-of-structured-reflection-for-midwifery-students-in-ireland
#18
Louise Gallagher, Denise Lawler, Vivienne Brady, Colm OBoyle, Anna Deasy, Kathryn Muldoon
Midwifery students undertaking the undergraduate midwifery education programme in Ireland participate in facilitated reflective sessions that aim to develop their skills of reflecting on and in clinical practice. This paper presents a qualitative evaluation of the appropriateness and effectiveness of the facilitated reflection sessions for pre and post-registration midwifery students in two large Dublin maternity teaching hospitals. The aim was to evaluate structured reflective practice sessions which sought to assist midwifery students to become competent reflective practitioners...
November 14, 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/27885856/ankle-impingement-syndromes-an-imaging-review
#19
Zachary T Berman, Monica Tafur, Sonya S Ahmed, Brady K Huang, Eric Y Chang
Ankle impingement syndromes encompass a broad spectrum of post-traumatic and chronic degenerative changes that present with pain on specific movements about the ankle joint. Both amateur and professional athletes are disproportionately affected by these conditions, and while conservative measures can potentially treat an impingement syndrome, definitive therapy often is alleviated surgically. Imaging (including conventional radiography, ultrasound, computed tomography, and magnetic resonance imaging) plays an invaluable role in the diagnosis and pre-surgical work-up...
November 25, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27882396/athina-markou-s-contributions-to-treatment-development-for-mental-illnesses-a-perspective
#20
EDITORIAL
Lois Winsky, Linda S Brady
No abstract text is available yet for this article.
November 24, 2016: Psychopharmacology
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