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https://www.readbyqxmd.com/read/27936243/can-wound-exudate-from-venous-leg-ulcers-measure-wound-pain-status-a-pilot-study
#1
Taichi Goto, Nao Tamai, Gojiro Nakagami, Aya Kitamura, Ayumi Naito, Masayuki Hirokawa, Chisako Shimokawa, Kazuo Takahashi, Junichi Umemoto, Hiromi Sanada
We investigated the associations between the self-evaluated pain status and two pain biomarker candidates, nerve growth factor and S100A8/A9, in exudate from venous leg ulcer to finally develop an objective pain evaluation method. Patients with venous leg ulcer participated in this cross-sectional observational study conducted between April and October 2014 at two medical facilities. During routine wound care, each participant self-evaluated their pain status at each examination using the 10-point numerical rating scale (present pain intensity) and the short-form McGill Pain Questionnaire 2 (continuous pain, intermittent pain, neuropathic pain, affective descriptors, and total score)...
2016: PloS One
https://www.readbyqxmd.com/read/27936189/impact-of-attending-physicians-comments-on-residents-workloads-in-the-emergency-department-results-from-two-j-o-pan-randomized-controlled-trials
#2
Akira Kuriyama, Noriyuki Umakoshi, Jun Fujinaga, Toshie Kaihara, Seigo Urushidani, Naoki Kuninaga, Motohiro Ichikawa, Shinichiro Ienaga, Akira Sasaki, Tetsunori Ikegami
OBJECTIVE: To examine whether peppy comments from attending physicians increased the workload of residents working in the emergency department (ED). METHODS: We conducted two parallel-group, assessor-blinded, randomized trials at the ED in a tertiary care hospital in western Japan. Twenty-five residents who examined either ambulatory (J(^o^)PAN-1 Trial) or transferred patients (J(^o^)PAN-2 Trial) in the ED on weekdays. Participants were randomly assigned to groups that either received a peppy message such as "Hope you have a quiet day!" (intervention group) or did not (control group) from the attending physicians...
2016: PloS One
https://www.readbyqxmd.com/read/27936067/deletion-at-the-gcnt2-locus-causes-autosomal-recessive-congenital-cataracts
#3
Bushra Irum, Shahid Y Khan, Muhammad Ali, Muhammad Daud, Firoz Kabir, Bushra Rauf, Fareeha Fatima, Hira Iqbal, Arif O Khan, Saif Al Obaisi, Muhammad Asif Naeem, Idrees A Nasir, Shaheen N Khan, Tayyab Husnain, Sheikh Riazuddin, Javed Akram, Allen O Eghrari, S Amer Riazuddin
PURPOSE: The aim of this study is to identify the molecular basis of autosomal recessive congenital cataracts (arCC) in a large consanguineous pedigree. METHODS: All participating individuals underwent a detailed ophthalmic examination. Each patient's medical history, particularly of cataracts and other ocular abnormalities, was compiled from available medical records and interviews with family elders. Blood samples were donated by all participating family members and used to extract genomic DNA...
2016: PloS One
https://www.readbyqxmd.com/read/27936059/baroreflex-sensitivity-predicts-short-term-outcome-of-postural-tachycardia-syndrome-in-children
#4
Hongxia Li, Ying Liao, Yuli Wang, Ping Liu, Chufan Sun, Yonghong Chen, Chaoshu Tang, Hongfang Jin, Junbao Du
OBJECTIVE: The study was designed to examine if baroreflex sensitivity (BRS) could predict the short-term outcome of postural tachycardia syndrome (POTS) in children. METHODS: Seventy-seven children subjects were included in the study. Among them, 45 children were in the POTS group and another 32 healthy children were in the control group. A ninety-day clinical follow-up was conducted and the symptom score before and after the follow-up was calculated for POTS patients by using POTS score system...
2016: PloS One
https://www.readbyqxmd.com/read/27935995/into-the-bowels-of-depression-unravelling-medical-symptoms-associated-with-depression-by-applying-machine-learning-techniques-to-a-community-based-population-sample
#5
Joanna F Dipnall, Julie A Pasco, Michael Berk, Lana J Williams, Seetal Dodd, Felice N Jacka, Denny Meyer
BACKGROUND: Depression is commonly comorbid with many other somatic diseases and symptoms. Identification of individuals in clusters with comorbid symptoms may reveal new pathophysiological mechanisms and treatment targets. The aim of this research was to combine machine-learning (ML) algorithms with traditional regression techniques by utilising self-reported medical symptoms to identify and describe clusters of individuals with increased rates of depression from a large cross-sectional community based population epidemiological study...
2016: PloS One
https://www.readbyqxmd.com/read/27935991/a-competency-model-for-clinical-physicians-in-china-a-cross-sectional-survey
#6
Zhuang Liu, Lei Tian, Qing Chang, Baozhi Sun, Yuhong Zhao
BACKGROUND: Around the world, regulatory bodies have taken the lead in determining the competencies required to become a physician. As a first step in addressing this project, it was decided to develop a set of core competencies that were unique to China and that might serve as a basis for medical education. The purpose of this paper was to construct a competency model for clinical physicians in China. METHODS: Data was collected using a cross-sectional survey of 6247 clinicians from seven administrative regions (31 provinces, autonomous regions and municipalities directly under the central government) in China...
2016: PloS One
https://www.readbyqxmd.com/read/27935971/costs-of-care-of-hiv-infected-children-initiating-lopinavir-ritonavir-based-antiretroviral-therapy-before-the-age-of-two-in-cote-d-ivoire
#7
Sophie Desmonde, Divine Avit, Junie Petit, Madeleine Amorissani Folquet, Francois Tanoh Eboua, Clarisse Amani Bosse, Evelyne Dainguy, Véronique Mea, Marguerite Timite-Konan, Sylvie Ngbeché, Andrea Ciaranello, Valeriane Leroy
OBJECTIVES: To access the costs of care for Ivoirian children before and after initiating LPV/r-based antiretroviral therapy (ART) before the age of two. METHODS: We assessed the direct costs of care for all HIV-infected children over the first 12 months on LPV/r-based ART initiated <2 years of age in Abidjan. We recorded all drug prescriptions, ART and cotrimoxazole prophylaxis delivery, medical analyses/examinations and hospital admissions. We compared these costs to those accrued in the month prior to ART initiation...
2016: PloS One
https://www.readbyqxmd.com/read/27935933/comprehensive-diabetes-and-non-communicable-disease-educator-in-the-low-resource-settings
#8
M D Bhattarai
The role of self-management education in diabetes and other major non-communicable diseases is clearly evident. To take care of and educate people with diabetes and other major NCD under the supervision of medical professionals and for education of other health care professionals, Comprehensive Diabetes and NCD Educators are needed in the routine service in peripheral health clinics and hospitals. The areas of training of CDNCD educator should match with the cost-effective interventions for diabetes and other major NCD that are feasible and planned for implementation in primary care in the low resource settings...
April 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935915/medication-practice-of-patients-with-dermatophytosis
#9
Y Poudyal, S D Joshi
INTRODUCTION: Dermatophytosis is one of the commonest dermatoses observed in Dermatology OPD. It is caused by Fungus Dermatophyte. Its pattern and prevalence varies from region to region. As self medication practice is very common, we aim to find the prevalence of various clinical pattern of dermatophytosis and to find out the medication commonly used by the patients for this condition. METHODS: This was cross sectional observational study. The case collection was done from outpatient department of Dermatology and Venereology of a Teaching Hospital from 15th March, 2013 to 14 March, 2014...
July 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935890/-surgical-prevention-of-ischaemic-strokes-by-means-of-an-extraintracranial-microanastomosis-eicma-in-the-carotid-basin
#10
V V Krylov, V A Luk'yanchikov, A S Tokarev, O Yu Nakhabin, N A Polunina, I V Sen'ko, V A Dalibaldyan, E V Grigor'eva, N E Kudryashova, G K Guseinova, E V Udodov, T A Fedulova
BACKGROUND: Not less than 50% of all ischaemic strokes appear to occur resulting from pathology of extracranial arteries. Occlusions and stenoses are more commonly encountered in carotid arteries, with the incidence of occlusion of the internal carotid artery (ICA) ranging from 5 to 10% within the structure of all lesions of brachiocephalic arteries (BCA). AIM: The study was aimed at assessing the results of a surgical procedure of extra-intracranial microanastomosis (EICMA) performed in patients presenting with occlusive and stenotic lesions of BCA at the Neurosurgical Department...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935881/-contrast-free-mr-phlebography-as-a-method-of-screening-of-phlebothromboses-and-extravasal-compression-of-the-inferior-vena-cava-and-its-basin
#11
V V Shebryakov, G G Karmazanovsky, Yu M Stoiko, K V Mazaishvili, D K Lyutarevich, S Yu Kim, M V Fel'dsherov, M N Yashkin
The study was aimed at assessing possibilities and determining diagnostic significance of the method of contrast-free magnetic resonance phlebography (MR phlebography) in diagnosis of diseases of the inferior vena cava (IVC) and its basin. Presented herein is experience with examining a total of 74 patients at two therapeutic-diagnostic facilities: the National Medical Surgical Centre named after N.I. Pirogov and the Medical Diagnostic Centre "Ramsey Diagnostics". The studies were carried out on magnetic resonance tomographs "Philips Intera Nova" and "GE Optima MR360", using a special protocol of contrast-free MR-phlebography in consequences at free breathing, followed by 3D reconstruction and processing of the obtained images as MIP and 3D...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935543/acoustic-neuroma-as-first-sign-of-inner-ear-functional-disorders
#12
Marzena Bielińska, Kalina Owczarek, Joanna Nowosielska-Grygiel, Jurek Olszewski, Piotr Pietkiewicz
INTRODUCTION: The aim of this work was to describe acoustic neuromas as the first signs of inner ear functional disorders. MATERIAL AND METHODS: The study covered 3,456 audiological and otoneurological patients, who were treated in the Department of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics Military Medical Academy University Teaching Hospital in Lodz within the period of 2011-2016. Among the studied subjects, an acoustic neuroma on the vestibulocochlear nerve was diagnosed in 13 cases (5,16%), including 9 women and 4 men...
October 31, 2016: Otolaryngologia Polska. the Polish Otolaryngology
https://www.readbyqxmd.com/read/27935150/trends-in-potentially-inappropriate-medication-prescribing-to-nursing-home-patients-comparison-of-three-cross-sectional-studies
#13
Kjell H Halvorsen, Geir Selbaek, Sabine Ruths
PURPOSE: The aim of this study was to examine trends in potentially inappropriate medication (PIM) prescribing in Norwegian nursing homes. METHODS: Patients aged ≥70 years were included from three cross-sectional studies conducted in 1997, 2005 and 2011. PIMs were analyzed according to the Norwegian General Practice-Nursing Home criteria (NORGEP-NH), use of single substances to avoid, combinations to avoid, and deprescribing items. Associations between sample and use of PIMs were examined by logistic regression, adjusted for age, gender, and ward...
December 9, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27935019/family-caregiver-factors-associated-with-unmet-needs-for-care-of-older-adults
#14
Scott R Beach, Richard Schulz
OBJECTIVES: To examine caregiver factors associated with unmet needs for care of older adults. DESIGN: Population-based surveys of caregivers and older adult care recipients in the United States in 2011. SETTING: 2011 National Health and Aging Trends Study and National Study of Caregiving. PARTICIPANTS: Family caregivers (n = 1,996) of community-dwelling older adults with disabilities (n = 1,366). MEASUREMENTS: Disabled care recipient reports of unmet needs for care in the past month with activities of daily living (ADLs; e...
December 9, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27934791/comparison-of-single-incision-and-multi-incision-diagnostic-laparoscopy-on-evaluation-of-diaphragmatic-status-after-left-thoracoabdominal-penetrating-stab-wounds
#15
Mehmet Ilhan, Ali Fuat Kaan Gök, Süleyman Bademler, Ömer Cenk Cücük, Yiğit Soytaş, Hakan Teoman Yanar
AIM: Single incision diagnostic laparoscopy (SIDL) may be an alternative procedure to multi-incision diagnostic laparoscopy (MDL) for penetrating thoracoabdominal stab wounds. The purpose of this study is sharing our experience and comparing two techniques for diaphragmatic status. MATERIALS AND METHODS: Medical records of 102 patients with left thoracoabdominal penetrating stab injuries who admitted to Istanbul School of Medicine, Trauma and Emergency Surgery Clinic between February 2012 and April 2016 were examined...
January 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27934657/the-importance-of-quality-specifications-in-safety-assessments-of-amino-acids-the-cases-of-l-tryptophan-and-l-citrulline
#16
REVIEW
Hellen A Oketch-Rabah, Amy L Roe, Bill J Gurley, James C Griffiths, Gabriel I Giancaspro
The increasing consumption of amino acids from a wide variety of sources, including dietary supplements, natural health products, medical foods, infant formulas, athletic and work-out products, herbal medicines, and other national and international categories of nutritional and functional food products, increases the exposure to amino acids to amounts far beyond those normally obtained from the diet, thereby necessitating appropriate and robust safety assessments of these ingredients. Safety assessments of amino acids, similar to all food constituents, largely rely on the establishment of an upper limit [Tolerable Upper Intake Level (UL)] considered to be a guide for avoiding high intake, above which adverse or toxic effects might occur...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27934557/surgical-complications-after-kidney-transplantation
#17
Mehmet Haberal, Fatih Boyvat, Aydıncan Akdur, Mahir Kırnap, Ümit Özçelik, Feza Yarbuğ Karakayalı
Since the first successful organ transplant conducted between twins in 1954, kidney transplant has evolved considerably over the past 50 years. Kidney transplant plays an important role in the treatment of end-stage kidney disease to improve the quality of life and prolong the life of patients. Despite significant advances, postoperative medical and surgical complications still represent important causes of morbidity and mortality. Many problems can be avoided through prophylactic correction of abnormalities detected during the preoperative evaluation; however, it is critical that technical mishaps at all stages of the transplant process (donor nephrectomy, benchwork preparation, and implant) be prevented and that careful postoperative monitoring be carried out, including thorough examination by attending physicians...
December 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27934556/room-for-improvement-palliating-the-ego-in-feedback-resistant-medical-students
#18
Andrew Perrella
Feedback in medical education provides the impetus for growth in a field pressured to demonstrate continuous progress. Unfortunately, as it always incorporates some level of judgment, certain students appear more resistant than receptive to receiving feedback. Coupled with the ubiquitous stressors of medicine-examinations, perpetual knowledge acquisition, competition for employment-there subtly emerges a learning environment in which the mindset of medical trainees morphs from collegiality to outperformance of one's peers...
December 9, 2016: Medical Teacher
https://www.readbyqxmd.com/read/27934119/mechanical-properties-based-particle-separation-via-traveling-surface-acoustic-wave
#19
Zhichao Ma, David J Collins, Jinhong Guo, Ye Ai
Most microfluidics-based sorting methodologies utilize size differences between suspended micro-objects as the defining characteristic by which they are sorted. Sorting based on mechanical properties, however, would provide a new avenue for sample preparation, detection and diagnosis for a number of emerging biological and medical analyses. In this study, we demonstrate separation of polystyrene (PS) and poly(methyl methacrylate) (PMMA) microspheres based entirely on their difference in mechanical properties using traveling surface acoustic waves (TSAWs)...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27933732/hypothesis-driven-physical-examination-curriculum
#20
Sharon Allen, Andrew Olson, Jeremiah Menk, James Nixon
BACKGROUND: Medical students traditionally learn physical examination skills as a rote list of manoeuvres. Alternatives like hypothesis-driven physical examination (HDPE) may promote students' understanding of the contribution of physical examination to diagnostic reasoning. We sought to determine whether first-year medical students can effectively learn to perform a physical examination using an HDPE approach, and then tailor the examination to specific clinical scenarios. Medical students traditionally learn physical examination skills as a rote list of manoeuvres CONTEXT: First-year medical students at the University of Minnesota were taught both traditional and HDPE approaches during a required 17-week clinical skills course in their first semester...
December 9, 2016: Clinical Teacher
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