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https://www.readbyqxmd.com/read/29050240/total-flavones-of-abelmoschus-manihot-enhances-angiogenic-ability-both-in-vitro-and-in-vivo
#1
Lingyi Tang, Wu Pan, Guisong Zhu, Zhihui Liu, Dongling Lv, Meng Jiang
Angiogenesis is a process of new blood vessel formation from pre-existing vessels. It is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. Total flavones of Abelmoschus manihot (TFA) are the major constituents of the traditional Chinese herb Abelmoschus manihot L. Medic. The aim of this study is to investigate the effect of TFA on angiogenic ability using human umbilical vein endothelial cells (HUVECs) in vitro and chick chorioallantoic membrane (CAM) in vivo...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050194/update-on-the-pathophysiology-and-management-of-anorectal-disorders
#2
REVIEW
Tanisa Patcharatrakul, Satish S C Rao
Anorectal disorders are common and present with overlapping symptoms. They include several disorders with both structural and functional dysfunction(s). Because symptoms alone are poor predictors of the underlying pathophysiology, a diagnosis should only be made after evaluating symptoms and physiologic and structural abnormalities. A detailed history, a thorough physical and digital rectal examination and a systematic evaluation with high resolution and/or high definition three-dimensional (3D) anorectal manometry, 3D anal ultrasonography, magnetic resonance defecography and neurophysiology tests are essential to correctly identify these conditions...
October 23, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29050190/-current-research-of-sympathetic-ophthalmia
#3
Y Di, J J Ye
Sympathetic ophthalmia (SO) is a rare, bilateral, non-necrotizing, granulomatous uveitis that usually occurs after open ocular injury or intraocular surgery. The pathophysiology is not clearly understood, but generally SO is an immediate hypersensitivity mediated by T lymphocytes which are related to ocular tissue antigens. The main histopathological features are granulation tissues composed of lymphocytes, macrophages and multinucleated giant cells. The clinical manifestations are different from person to person, which might be mild or severe...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050189/-clinical-features-and-treatments-of-retrocorneal-fungal-infection
#4
J Cheng, H L Zhai, J Y Wang, L X Xie
Objective: To evaluate the clinical features of retrocorneal fungal infection and the therapeutic effects. Methods: This was a retrospective, noncomparative study of nine patients with retrocorneal fungal infection and an intact corneal epithelium treated at Qingdao Eye Hospital. The history, clinical features, diagnostic methods, pathogens and therapeutic effects were analyzed. Results: Five patients had a history of trauma by plant, two had a non-plant injury, and two had unidentified reasons. The duration between the initial onset and the first visit to our hospital was 7...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050177/-application-of-three-dimensional-visualization-in-pancreatic-tumor-a-pilot-study
#5
S Z Wang, X B Wang, M Li, R X Shen, H Rong, J S Li
Objective: To study the value of three-dimensional(3D) visualization in the diagnosis and surgical treatment for pancreatic tumor. Methods: From June to September 2016, 26 patients with pancreatic tumors in Jinling Hospital, Medical School of Nanjing University were involved. The study included 26 patients(8 females and 18 males) with mean age of (57±12)years (ranging from 23 to 77 years). And there were 20 malignant tumors and 6 benign tumors. All of them were examined with abdominal thin slice CT scanning and the CT images were imported into 3D visualization system for 3D visualization...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29050176/-analysis-of-diagnosis-therapy-and-prognosis-factors-of-103-patients-with-pancreatic-neuroendocrine-tumors
#6
Q Luo, Y N Liu, H Y Ma, S Li, J Y Huang, G Li, G Jin
Objective: To discuss the clinical pathology characteristics, strategies of diagnosis and therapy, and related prognosis factors of pancreatic neuroendocrine tumors(pNET). Methods: Clinical data of 103 pNET cases in Department of Pancreatic Surgery, Changhai Hospital of Second Military Medical University were collected from January 2006 to December 2015. There were 44 males and 59 females, aged from 21 to 77 years with mean age of 48 years.Of the 103 patients, there were functional type in 21 cases and no functional type in 82 cases...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29050150/-diagnostic-value-analysis-of-capsule-endoscopy-in-obscure-gastrointestinal-bleeding-patients-of-different-ages
#7
C S E Wang, J N Li, Y N Wang, H Yang, J M Qian
Objective: To evaluate the diagnostic value of capsular endoscopy in patients with obscure gastrointestinal bleeding (OGIB) in different age groups, and assess its effectiveness and safety. Methods: A total of 216 patients who were diagnosed with OGIB between March 2005 and March 2016 at Department of Gastroenterology of Peking Union Medical College Hospital were retrospectively reviewed. They were assigned into three groups: young adults, middle-aged and elderly. The demographic characteristics, clinical manifestations, working performance as well as endoscopic features in each group were collected and analyzed...
September 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29050061/-perioperative-anaphylaxia-on-drugs
#8
Wolfgang Pfützner, Hinnerk Wulf
The diagnostic evaluation of perioperative anaphylaxia is of great importance for the medical care of the affected persons in the context of renewed interventions in general anesthesia. The most frequent triggers include muscle relaxants, antibiotics, latex and analgesics of the type of the cyclooxygenase inhibitors, but other perioperatively administered drugs such as opioids, anesthetics, benzodiazepines, dyes, disinfectants and even corticosteroids or drug additives may also be the cause in rare cases. The most important aim is therefore the identification of the responsible drug, for which a near-time allergological diagnosis should be carried out within the first 4 weeks to 6 months after the reaction...
October 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29049907/clinical-correlates-of-saccadic-eye-movement-in-antipsychotic-na%C3%A3-ve-schizophrenia
#9
Aditi Subramaniam, Vijay Danivas, Sri Mahavir Agarwal, Sunil Kalmady, Venkataram Shivakumar, Anekal C Amaresha, Anushree Bose, Janardhanan C Narayanaswamy, Shivarama Varambally, Samuel B Hutton, Ganesan Venkatasubramanian, Bangalore N Gangadhar
Some aspects of saccadic performance have been found to be abnormal in chronic schizophrenia. The majority of this research has, however, been performed on patients treated with long-term antipsychotic medication. Very few studies have examined saccadic performance in antipsychotic-naïve/free patients. There are also very few studies describing the relationship between saccadic performance and clinical symptoms, particularly in antipsychotic free patients. In this study, we compared pro and antisaccade performance in a large sample of antipsychotic-naïve/free schizophrenia patients (N = 45) with healthy controls (N = 57)...
October 4, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29049553/evaluating-industry-payments-among-dermatology-clinical-practice-guidelines-authors
#10
Jake X Checketts, Matthew Thomas Sims, Matt Vassar
Importance: It is well documented that financial conflicts of interest influence medical research and clinical practice. Prior to the Open Payments provisions of the Affordable Care Act, financial ties became apparent only through self-disclosure. The nature of financial interests has not been studied among physicians who develop dermatology clinical practice guidelines. Objective: To evaluate payments received by physicians who author dermatology clinical practice guidelines, compare disclosure statements for accuracy, determine whether pharmaceutical companies from which the authors received payments manufactured products related to the guidelines, and examine the extent to which the American Academy of Dermatology enforced their Administrative Regulations for guideline development...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29049517/-job-lock-among-long-term-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#11
Anne C Kirchhoff, Ryan Nipp, Echo L Warner, Karen Kuhlthau, Wendy M Leisenring, Karen Donelan, Julia Rabin, Giselle K Perez, Kevin C Oeffinger, Paul C Nathan, Leslie L Robison, Gregory T Armstrong, Elyse R Park
Importance: Childhood cancer survivors may be reluctant to make changes in their employment because of access to health insurance. Objective: To examine the prevalence of "job lock" (staying at a job to keep work-related health insurance) in a sample drawn from an established, multi-institutional cohort of full-time employed childhood cancer survivors compared with a random sample of siblings and to explore factors associated with job lock among cancer survivors...
October 19, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29049512/time-requirements-for-electronic-health-record-use-in-an-academic-ophthalmology-center
#12
Sarah Read-Brown, Michelle R Hribar, Leah G Reznick, Lorinna H Lombardi, Mansi Parikh, Winston D Chamberlain, Steven T Bailey, Jessica B Wallace, Thomas R Yackel, Michael F Chiang
Importance: Electronic health record (EHR) systems have transformed the practice of medicine. However, physicians have raised concerns that EHR time requirements have negatively affected their productivity. Meanwhile, evolving approaches toward physician reimbursement will require additional documentation to measure quality and cost of care. To date, little quantitative analysis has rigorously studied these topics. Objective: To examine ophthalmologist time requirements for EHR use...
October 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29049425/comparison-of-internal-medicine-and-general-surgery-residents-assessments-of-risk-of-postsurgical-complications-in-surgically-complex-patients
#13
James M Healy, Kimberly A Davis, Kevin Y Pei
Importance: Anticipating postsurgical complications is a vital physician skill, particularly when counseling surgically complex patients on their risks of intervention. Although internists and surgeons both counsel patients on surgical risks, it is uncertain who is better equipped to accurately anticipate surgical complications. Objective: To examine how internal medicine and general surgery trainees compare in their assessment of risk of surgically complex patients...
October 11, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049401/risk-factors-for-intrahepatic-and-extrahepatic-cholangiocarcinoma-in-the-united-states-a-population-based-study-in-seer-medicare
#14
Jessica L Petrick, Baiyu Yang, Sean F Altekruse, Alison L Van Dyke, Jill Koshiol, Barry I Graubard, Katherine A McGlynn
OBJECTIVES: Intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinomas are rare tumors that arise from the epithelial cells of the bile ducts, and the etiology of both cancer types is poorly understood. Thus, we utilized the Surveillance, Epidemiology, and End Results (SEER)-Medicare resource to examine risk factors and novel preexisting medical conditions that may be associated with these cancer types. METHODS: Between 2000 and 2011, 2,092 ICC and 2,981 ECC cases and 323,615 controls were identified using the SEER-Medicare database...
2017: PloS One
https://www.readbyqxmd.com/read/29049396/improved-data-validity-in-the-swedish-register-of-palliative-care
#15
Lisa Martinsson, Per-Anders Heedman, Staffan Lundström, Bertil Axelsson
INTRODUCTION: The Swedish Register of Palliative Care (SRPC) is a national quality register that collects data about end-of-life care from healthcare providers that care for dying patients. Data are used for quality control and research. Data are mainly collected with an end-of-life questionnaire (ELQ), which is completed by healthcare staff after the death of a patient. A previous validity assessment of the ELQ showed insufficient validity in some items including symptom relief. The aim of this study was to examine the validity of the revised ELQ...
2017: PloS One
https://www.readbyqxmd.com/read/29049325/effect-of-therapeutic-interchange-on-medication-reconciliation-during-hospitalization-and-upon-discharge-in-a-geriatric-population
#16
Jessica S Wang, Robert L Fogerty, Leora I Horwitz
BACKGROUND: Therapeutic interchange of a same class medication for an outpatient medication is a widespread practice during hospitalization in response to limited hospital formularies. However, therapeutic interchange may increase risk of medication errors. The objective was to characterize the prevalence and safety of therapeutic interchange. METHODS AND FINDINGS: Secondary analysis of a transitions of care study. We included patients over age 64 admitted to a tertiary care hospital between 2009-2010 with heart failure, pneumonia, or acute coronary syndrome who were taking a medication in any of six commonly-interchanged classes on admission: proton pump inhibitors (PPIs), histamine H2-receptor antagonists (H2 blockers), hydroxymethylglutaryl CoA reductase inhibitors (statins), angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and inhaled corticosteroids (ICS)...
2017: PloS One
https://www.readbyqxmd.com/read/29049313/study-on-association-of-working-hours-and-occupational-physical-activity-with-the-occurrence-of-coronary-heart-disease-in-a-chinese-population
#17
Yao Ma, Ying-Jun Wang, Bing-Rui Chen, Hao-Jie Shi, Hao Wang, Mohammad Reeaze Khurwolah, Ya-Fei Li, Zhi-Yong Xie, Yang Yang, Lian-Sheng Wang
OBJECTIVE: To explore the association of working hours and occupational physical activity (OPA) with the occurrence of coronary heart disease (CHD) in a Chinese population. METHODS: A total of 595 participants (354 and 241 patients with and without CHD, respectively) aged between 24 and 65 were enrolled in our study, which was conducted at the First Affiliated Hospital of Nanjing Medical University between December 2015 and October 2016. Participant characteristics were collected from face-to-face questionnaires, and logistic regression analysis was conducted to examine the association of working hours and OPA with the occurrence of CHD...
2017: PloS One
https://www.readbyqxmd.com/read/29049265/medical-grade-honey-dressing-use-in-developing-countries
#18
George Frederick Winter
Compared with other medical honeys, SurgihoneyRO (H&R Healthcare Ltd, Southmoor, Abingdon, United Kingdom), a bioengineered medical-grade honey, delivers low concentrations of reactive oxygen to wounds over a sustained period. This article describes how one provider, Dr Jill Brooks, has successfully used this new antimicrobial dressing in Africa and examines the potential positive impact this dressing could have on wound care in developing countries.
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29049253/clinical-efficacy-analysis-of-ahmed-glaucoma-valve-implantation-in-neovascular-glaucoma-and-influencing-factors-a-strobe-compliant-article
#19
Ye He, Ying Tian, Weitao Song, Ting Su, Haibo Jiang, Xiaobo Xia
This study aimed to evaluate the efficacy of Ahmed glaucoma valve (AGV) implantation in treating neovascular glaucoma (NVG) and to analyze the factors influencing the surgical success rate.This is a retrospective review of 40 eyes of 40 NVG patients who underwent AGV implantation at Xiangya Hospital of Central South University, China, between January 2014 and December 2016. Pre- and postoperative intraocular pressure (IOP), visual acuity, surgical success rate, medications, and complications were observed. Surgical success criteria were defined as IOP ≤21 and >6 mm Hg with or without additional medications...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049234/case-report-features-of-hand-foot-and-mouth-disease-in-neonates
#20
Wen-Wen Chen, Zhao-Bin Yang, Lian-Shu Lian, Li-Ping Xu
RATIONALE: Hand, foot and mouth disease (HFMD) is caused by enterovirus. The virus may exist in secretions. PATIENT CONCERNS: Five neonates had symptoms of fever and maculopapular rashes involving face, trunk, breech, arms, and legs, especially scattering on palms and feet. Blood, oropharyngeal fluid, urine, and cerebrospinal fluid (CSF) samples were collected and detected for further diagnoses with the consent of the infants' parents. Some of them suffered aseptic meningitis...
October 2017: Medicine (Baltimore)
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