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Heme oxygenase-1

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https://www.readbyqxmd.com/read/29452096/the-macrophage-heme-heme-oxygenase-1-system-and-its-role-in-inflammation
#1
REVIEW
Vijith Vijayan, Frank A D T G Wagener, Stephan Immenschuh
Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO, plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are mediated via the catalytic breakdown of heme, which is an iron-containing tetrapyrrole complex with potential pro-oxidant and pro-inflammatory effects. The HO reaction produces the antioxidant and anti-inflammatory compounds carbon monoxide (CO) and biliverdin, subsequently converted into bilirubin, along with iron, which is reutilized for erythropoiesis...
February 13, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29449858/exogenous-hydrogen-peroxide-contributes-to-heme-oxygenase-1-delaying-programmed-cell-death-in-isolated-aleurone-layers-of-rice-subjected-to-drought-stress-in-a-cgmp-dependent-manner
#2
Guanghui Wang, Yu Xiao, Xiaojiang Deng, Heting Zhang, Tingge Li, Huiping Chen
Hydrogen peroxide (H 2 O 2 ) is a reactive oxygen species (ROS) that plays a dual role in plant cells. Here, we discovered that drought (20% polyethylene glycol-6000, PEG)-triggered decreases of HO-1 transcript expression and HO activity. However, exogenous H 2 O 2 contributed toward the increase in HO-1 gene expression and activity of the enzyme under drought stress. Meanwhile, the HO-1 inducer hematin could mimic the effects of the H 2 O 2 scavengers ascorbic acid (AsA) and dimethylthiourea (DMTU) and the H 2 O 2 synthesis inhibitor diphenyleneiodonium (DPI) for scavenging or diminishing drought-induced endogenous H 2 O 2 ...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29436680/curcumin-increases-cholesterol-efflux-via-heme-oxygenase%C3%A2-1%C3%A2-mediated-abca1-and-sr%C3%A2-bi-expression-in-macrophages
#3
Yi Zhong, Jian Feng, Zhongcai Fan, Jiafu Li
Curcumin, which is an extract from a traditional Chinese medicine, has previously been demonstrated to exhibit an anti‑atherosclerotic effect, which is closely associated with an increase in cholesterol efflux. However, it is unclear as to whether the increased effect is mediated by heme oxygenase (HO)‑1. Macrophages were treated with different concentrations of curcumin, HO‑1 inhibitor and small interfering (si)RNA in different experiments. Analysis of protein expression was conducted via western blotting...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436598/madecassoside-activates-anti%C3%A2-neuroinflammatory-mechanisms-by-inhibiting-lipopolysaccharide%C3%A2-induced-microglial-inflammation
#4
Andrew Octavian Sasmita, Anna Pick Kiong Ling, Kenny Gah Leong Voon, Rhun Yian Koh, Ying Pei Wong
Neurodegeneration is typically preceded by neuroinflammation generated by the nervous system to protect itself from tissue damage, however, excess neuroinflammation may inadvertently cause more harm to the surrounding tissues. Attenuating neuroinflammation with non‑steroidal anti‑inflammatory drugs can inhibit neurodegeneration. However, such treatments induce chronic side effects, including stomach ulcers. Madecassoside, a triterpene derived from Centella asiatica, is considered to be an alternative treatment of inflammation...
February 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29433360/ampk-nrf2-signaling-is-involved-in-the-anti-neuroinflammatory-action-of-petatewalide-b-from-petasites-japonicus-against-lipopolysaccharides-in-microglia
#5
Sun Young Park, Min Hyun Choi, Mei Li, Ke Li, Geuntae Park, Young-Whan Choi
OBJECTIVES: Abnormal microglia secrete neuroinflammatory factors that play a pivotal role in neurodegenerative-disorder development. Thus, regulating abnormal microglia-activation could be a promising therapeutic strategy. The purposes of this study included investigating the effect of Petatewalide B on lipopolysaccharide- (LPS-) stimulated microglia and exploring the role of the AMPK/Nrf2- (adenosine monophosphate-activated protein kinase/nuclear factor erythroid 2-related factor 2) signaling pathway in the anti-neuroinflammatory function of Petatewalide B...
February 12, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29429149/carbon-monoxide-ameliorates-6-hydroxydopamine-induced-cell-death-in-c6-glioma-cells
#6
Hyewon Moon, Jung-Hee Jang, Tae Chang Jang, Gyu Hwan Park
Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts therapeutic actions under various pathological conditions including liver failure, heart failure, gastric cancer, and cardiac arrest. However, little has been known about the effect of CO in neurodegenerative diseases like Parkinson's disease (PD). To test whether CO could exert a beneficial action during oxidative cell death in PD, we examined the effects of CO on 6-hydroxydopamine (6-OHDA)-induced cell death in C6 glioma cells...
February 12, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29425821/mmp9-is-involved-in-ho-1-mediated-upregulation-of-apical-junctional-complex-in-caco-2-cells-under-oxygen-glucose-deprivation
#7
Yongqu Lu, Jie An, Yulin Liu, Lehao Ren, Li Zhang
Ischemia reperfusion injury is a critical factor in the recovery process after intestine trauma and the functional restoration of intestinal reconstruction. This study was the first to explore the expression of apical junctional complex (AJC) induced by heme oxygenase-1 (HO-1) in Caco-2 cells in oxygen-glucose deprivation (OGD) models. Here we showed that HO-1 was upregulated after OGD. Notably, activation of HO-1 largely enhanced the expression of AJC proteins including Claudin-4, E-cadherin and β-catenin in Caco-2 cells, but decreased the expression of matrix metalloproteinase 9 (MMP9)...
February 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29421595/improvement-of-cisplatin-induced-renal-dysfunction-by-schisandra-chinensis-stems-via-anti-inflammation-and-anti-apoptosis-effects
#8
Yan-Zi Li, Shen Ren, Xiao-Tong Yan, Yin-Shi Sun, Hui-Ping Li, Wei Li, Ying-Ying Liu, Zi Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Schisandra chinensis (Turcz.) Baill (S. chinensis) is a frequently used traditional Chinese medicine, and modern pharmacological research has proven that S. chinensis has antioxidant, anti-hepatotox, anti-inflammatory, and anti-nephrotoxic effects. Cisplatin is widely used as antineoplastic drug at presenteffects, but the clinical application of cisplatin is limitedowing to nephrotoxicity. AIM OF THE STUDY: To demonstrate the renoprotective activity of the extract of the stems of Schisandra chinensis (SCE) in model mice established by cisplatin triggering acute kidney injury (AKI)...
February 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29421327/nrf2-protects-human-lens-epithelial-cells-against-h2o2-induced-oxidative-and-er-stress-the-atf4-may-be-involved
#9
Tian-Ju Ma, Di-Hui Lan, Shou-Zhi He, Zi Ye, Peng Li, Wei Zhai, Wen-Qian Chen, Yang Huang, Yu Fu, Ang Sun, Yi-Bing Wang, Zheng Ye, Jing-Lan Li, Yi Gao, Xin-Lin Yan, Zhao-Hui Li
Our previous study has shown heme oxygenase-1 (HO-1) protects human lens epithelial cells (LECs) against H2O2-induced oxidative stress and apoptosis. Nrf2, the major regulator of HO-1, is triggered during the mutual induction of oxidative stress and ER stress. In response to ER stress, unfolded protein response (UPR) serves as a program of transcriptional and translational regulation mechanism with PERK involved. Both Nrf2 and ATF4 are activated as the downstream effect of PERK signaling coordinating the convergence of dual stresses...
February 2, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29414639/oxyresveratrol-prevents-lipopolysaccharide-d-galactosamine-induced-acute-liver-injury-in-mice
#10
Ya-Nan Jia, Hai-Peng Lu, Ya-Lin Peng, Bao-Shun Zhang, Xiao-Bao Gong, Jun Su, You Zhou, Min-Hui Pan, Li Xu
Oxyresveratrol (Oxy) is a natural polyhydroxystilbene abundant in mulberry that has anti-inflammation and anti-oxidant activities. We evaluated the protective effect of Oxy in the context of the lipopolysaccharide and d-galactosamine (LPS/d-GalN) induced acute liver injury. Oxy restricted the development of histopathological changes, markedly reduced the activity of alanine transaminase (ALT) and aspartate transaminase (AST), which are indicators of impaired liver function. Oxy significantly regulated the contents of oxidative stress related enzymes and products, and inhibited expressions of inflammatory mediators and cytokines...
January 23, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29411263/naringenin-exerts-anti-inflammatory-effects-in-paraquat-treated-sh-sy5y-cells-through-a-mechanism-associated-with-the-nrf2-ho-1-axis
#11
Marcos Roberto de Oliveira, Cláudia Marlise Balbinotti Andrade, Cristina Ribas Fürstenau
Naringenin (NGN; 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one; C15H12O5), a flavanone, is found in citrus fruits and has been viewed as an antioxidant and anti-inflammatory agent. NGN is a potent inducer of the nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the expression of heme oxygenase-1 (HO-1), an enzyme exhibiting both antioxidant and anti-inflammatory effects. The complete mechanism by which NGN exerts anti-inflammatory actions is not completely understood yet. Therefore, we investigated here whether NGN would be able to reduce the inflammation induced by paraquat (PQ) in SH-SY5Y cells...
February 6, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29410018/linagliptin-potentiates-the-effect-of-l-dopa-on-the-behavioural-biochemical-and-immunohistochemical-changes-in-experimentally-induced-parkinsonism-role-of-toll-like-receptor-4-tgf-%C3%AE-1-nf-%C3%AE%C2%BAb-and-glucagon-like-peptide-1
#12
Ahmed M Kabel, Mohamed S Omar, Abdulrahman Alhadhrami, Salman S Alharthi, Majed M Alrobaian
OBJECTIVE: Our aim was to assess the effect of different doses of linagliptin with or without l-dopa/Carbidopa on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in mice. METHODS: Eighty Balb/c mice were divided into 8 equal groups: Control; MPTP; MPTP + l-dopa/Carbidopa; MPTP + linagliptin 3 mg/kg/day; MPTP + linagliptin 10 mg/kg/day; MPTP + Carboxymethyl cellulose; MPTP + l-dopa/Carbidopa + linagliptin 3 mg/kg/day and MPTP + l-dopa/Carbidopa + linagliptin 10 mg/kg/day...
January 30, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29408859/transcriptome-analysis-revealed-the-possible-regulatory-pathways-initiating-female-geese-broodiness-within-the-hypothalamic-pituitary-gonadal-axis
#13
Hehe Liu, Jiwen Wang, Liang Li, Chunchun Han, Hua He, Hengyong Xu
Geese have the strongest tendency toward broodiness among all poultry. The mechanisms initiating broodiness within the goose hypothalamic-pituitary-gonadal axis (HPGA) are still unclear. Here, we reported the transcriptome differences between laying and initial nesting within the HPGA tissues of geese. We constructed a unigene database based on HPGA tissues and identified 128,148 unigenes, 100% of which have been annotated. By using Digital Gene Expression (DGE) sequencing, we screened 19, 110, 289, and 211 differentially expressed genes (DEGs) in the hypothalamus, pituitary gland, stroma ovarii, and follicles, respectively, between laying and nesting geese...
2018: PloS One
https://www.readbyqxmd.com/read/29407753/schisandrin-c-enhances-odontoblastic-differentiation-through-autophagy-and-mitochondrial-biogenesis-in-human-dental-pulp-cells
#14
Jyoti Shrestha Takanche, Jeong-Seok Kim, Ji-Eun Kim, S-H Han, Ho-Keun Yi
OBJECTIVE: To investigate the role of Schisandrin C in odontoblastic differentiation, and its relations between autophagy and mitochondrial biogenesis in human dental pulp cells (HPDCs). DESIGN: Fresh third molars were used, and cultured for HDPCs. Western blotting technique, Alizarin red S staining, alkaline phosphatase (ALP) activity, and confocal microscopy were used to detect autophagy, mitochondrial biogenesis, and odontoblastic differentiation. To understand the mechanism of Schisandrin C, the HDPCs were treated with lipopolysaccharide (LPS), autophagy and heme oxygenase-1 (HO-1) inhibitors: 3-Methyladenine (3-MA) and Zinc protoporphyrin IX (ZnPP), respectively...
January 30, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29407319/dual-gas-treatment-with-hydrogen-and-carbon-monoxide-attenuates-oxidative-stress-and-protects-from-renal-ischemia-reperfusion-injury
#15
T Nishida, T Hayashi, T Inamoto, R Kato, N Ibuki, K Takahara, T Takai, Y Yoshikawa, T Uchimoto, K Saito, N Tanda, J Kouno, K Minami, H Uehara, H Hirano, H Nomi, Y Okada, H Azuma
BACKGROUND: Hydrogen (H2) and carbon monoxide (CO) gas are both reported to reduce reactive oxygen species and alleviate tissue ischemia-reperfusion (I-R) injury. The present study was conducted to evaluate the effects of a mixture of H2 gas and CO gas (dual gas) in comparison with hydrogen gas (H2: 2%) alone on I-R renal injury (composition of dual gas; N2: 77.8%; O2: 20.9%; H2: 1.30%; CO: 250 parts per million). METHODS: Adult male Sprague-Dawley rats (body weight 250-280 g) were divided into 5 groups: (1) sham operation control, (2) dual gas inhalation (dual treatment) without I-R treatment, (3) I-R renal injury, (4) H2 gas alone inhalation (H2 treatment) with I-R renal injury, and (5) dual treatment with I-R renal injury...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29406830/triiodothyronine-attenuates-the-progression-of-renal-injury-in-a-rat-model-of-chronic-kidney-disease
#16
Sahar Mohamed El Agaty
This study was designed to investigate whether and how triiodothyronine (T3) affects renal function in an experimental model of chronic kidney disease. Twenty four female rats were divided into: sham operated control group (n=8) , 5/6 nephrectomized group (Nx, n=8) and 5/6 nephrectomized group treated with T3 for 2 weeks (T3-Nx, n=8). T3 administration significantly decreased serum levels of urea, creatinine, tumour necrosis factor alpha, and interleukin-6 compared to Nx group. The levels of malondialdehyde , transforming growth factor beta, fibronectin, and collagen IV as well as the expression of inducible nitric oxide synthase, nuclear factor kappa B, poly ADP ribose polymerase, caspase-3 and Bax all were significantly decreased , though not normalized, in the remnant kidney of T3-Nx group compared to Nx rats...
February 6, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29398549/role-of-cadc-and-cadd-in-the-2-4-dichlorophenoxyacetic-acid-oxygenase-system-of-sphingomonas-agrestis-58-1
#17
Kumiko Kijima, Hajime Mita, Mitsuyasu Kawakami, Kei Amada
In the present study, we confirm that 2,4-dichlorophenoxyacetic acid (2,4-D) oxygenase from Sphingomonas agrestis 58-1 belongs to the family of Rieske non-heme iron aromatic ring-hydroxylating oxygenases, which comprise a core enzyme (oxygenase), ferredoxin, and oxidoreductase. It has previously been shown that cadAB genes are necessary for the conversion of 2,4-D to 2,4-dichlorophenol; however, the respective roles of ferredoxin and oxidoreductase in the 2,4-D oxygenase system from S. agrestis 58-1 remain unknown...
February 2, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29394238/plasmodium-salmonella-co-infection-induces-intense-inflammatory-responsanirban-pal-phd-cisr-central-institute-of-medicinal-and-aromatic-plants-lucknow-uttar-pradesh-indiae-oxidative-stress-and-liver-damage-a-mice-model-study-for-therapeutic-strategy
#18
Dinesh Kumar Patel, Sandeep Mittal, Nimisha Tiwari, Anil Kumar Maurya, Dhirendra Singh, Alok Kumar Pandey, Anirban Pal
Impairment of host immune response in malaria favours bacteraemia caused by typhoidal or non-typhoidal serovars of Salmonella enterica. Ofloxacin and Artesunate are the drugs that are clinically proven for treating typhoid and malaria respectively. The study evaluates the host responses upon treatment with antibiotic (Ofloxacin) and anti-malarial (Artesunate) in a standardized mice model harbouring co-infection. BALB/c mice (18-22 gm) were simultaneously co-infected with Plasmodium yoelii nigeriensis (Pyn) and Salmonella enterica Serovar Typhimurium (STm) and then treated with Ofloxacin or/and Artesunate from day 4 to day 7...
February 1, 2018: Shock
https://www.readbyqxmd.com/read/29394034/iron-and-its-role-in-cancer-defense-a-double-edged-sword
#19
Frank Thévenod
Iron (Fe) is an essential metal, vital for biological functions, including electron transport, DNA synthesis, detoxification, and erythropoiesis that all contribute to metabolism, cell growth, and proliferation. Interactions between Fe and O2 can result in the generation of reactive oxygen species (ROS), which is based on the ability of Fe to redox cycle. Excess Fe may cause oxidative damage with ensuing cell death, but DNA damage may also lead to permanent mutations. Hence Fe is carcinogenic and may initiate tumor formation and growth, and also nurture the tumor microenvironment and metastasis...
February 5, 2018: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/29393366/d%C3%A2-pinitol-alleviates-cyclosporine-a%C3%A2-induced-renal-tubulointerstitial-fibrosis-via-activating-sirt1-and-nrf2-antioxidant-pathways
#20
Eun Sil Koh, Soojeong Kim, Minyoung Kim, Yu Ah Hong, Seok Joon Shin, Cheol Whee Park, Yoon Sik Chang, Sungjin Chung, Ho-Shik Kim
Although the mechanism of cyclosporine A (CsA)‑induced renal injury remains to be fully elucidated, accumulating evidence suggests that oxidative stress is critical in producing CsA‑induced structural and functional renal impairment. The present study investigated the effect of D‑pinitol, a cyclitol present in soybean, on chronic CsA nephropathy. Male ICR mice were treated with vehicle, CsA (30 mg/kg/day), D‑pinitol (50 mg/kg/day) or a combination of CsA and D‑pinitol for 28 days. To assess which pathway responding to oxidative stress is augmented by D‑pinitol, the expression levels of several antioxidant enzymes and their possible regulators were measured...
January 19, 2018: International Journal of Molecular Medicine
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