keyword
MENU ▼
Read by QxMD icon Read
search

Heme oxygenase-1

keyword
https://www.readbyqxmd.com/read/29223540/protective-effect-of-coptisine-free-base-on-indomethacin-induced-gastric-ulcers-in-rats-characterization-of-potential-molecular-mechanisms
#1
Chaodan Luo, Hanbin Chen, Yongfu Wang, Guosheng Lin, Cailan Li, Lihua Tan, Ziren Su, Xiaoping Lai, Jianhui Xie, Huifang Zeng
AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS: CFB (10, 20 and 40mg/kg), berberine (20mg/kg) and lansoprazole (30mg/kg) were orally administrated to rats prior to indometacin ingestion, and gastric lesions were evaluated macroscopically and histologically, and further analyzed by ELISA, qRT-PCR and Western blot...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29220411/hexahydrocurcumin-protects-against-cerebral-ischemia-reperfusion-injury-attenuates-inflammation-and-improves-antioxidant-defenses-in-a-rat-stroke-model
#2
Piyawadee Wicha, Jiraporn Tocharus, Adchara Janyou, Jinatta Jittiwat, Chatchawan Changtam, Apichart Suksamrarn, Chainarong Tocharus
The purpose of the present experiment was to investigate whether hexahydrocurcumin (HHC) attenuates brain damage and improves functional outcome via the activation of antioxidative activities, anti-inflammation, and anti-apoptosis following cerebral ischemia/reperfusion (I/R). In this study, rats with cerebral I/R injury were induced by a transient middle cerebral artery occlusion (MCAO) for 2 h, followed by reperfusion. The male Wistar rats were randomly divided into five groups, including the sham-operated, vehicle-treated, 10 mg/kg HHC-treated, 20 mg/kg HHC-treated, and 40 mg/kg HHC-treated I/R groups...
2017: PloS One
https://www.readbyqxmd.com/read/29219807/down-regulation-of-cellular-protein-heme-oxygenase-1-inhibits-proliferation-of-avian-influenza-virus-h9n2-in-chicken-oviduct-epithelial-cells
#3
Xuefeng Qi, Huizhu Zhang, Tianxia Xue, Bo Yang, Meiyu Deng, Jingyu Wang
The pathogenesis of H9N2 subtype avian influenza virus (AIV) infection in hens is often related to oviduct tissue damage. Our previous study suggested that H9N2 AIV induces cellular apoptosis by activating reactive oxygen species (ROS) accumulation and mitochondria-mediated apoptotic signalling in chicken oviduct epithelial cells (COECs). Heme oxygenase-1 (HO-1) is an inducible enzyme that exerts protective effects against oxidative stress and activated HO-1 was recently shown to have antiviral activity. To study the potential involvement of HO-1 in H9N2 AIV proliferation, the role of its expression in H9N2-infected COECs was further investigated...
December 8, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29218050/heme-drives-oxidative-stress-associated-cell-death-in-human-neutrophils-infected-with-leishmania-infantum
#4
Graziele Quintela-Carvalho, Nívea F Luz, Fabiana S Celes, Dalila L Zanette, Daniela Andrade, Diego Menezes, Natália M Tavares, Claudia I Brodskyn, Deboraci B Prates, Marilda S Gonçalves, Camila I de Oliveira, Roque P Almeida, Marcelo T Bozza, Bruno B Andrade, Valeria M Borges
Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory analyses in a population of well characterized treatment-naïve VL patients as well as uninfected controls, who were part of previously reported studies. We noted a positive correlation between serum concentrations of heme with heme oxygenase-1 (HO-1) and lactate deydrogenase, as well as, a negative correlation between heme values and peripheral blood neutrophils counts...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29216542/loss-of-heme-oxygenase-1-accelerates-mesodermal-gene-expressions-during-embryoid-body-development-from-mouse-embryonic-stem-cells
#5
Yan-Liang Lai, Chen-Yu Lin, Wei-Cheng Jiang, Yen-Chun Ho, Chung-Huang Chen, Shaw-Fang Yet
Heme oxygenase (HO)-1 is an inducible stress response protein and well known to protect cells and tissues against injury. Despite its important function in cytoprotection against physiological stress, the role of HO-1 in embryonic stem cell (ESC) differentiation remains largely unknown. We showed previously that induced pluripotent stem (iPS) cells that lack HO-1 are more sensitive to oxidant stress-induced cell death and more prone to lose pluripotent markers upon LIF withdrawal. To elucidate the role of HO-1 in ESC differentiation and to rule out the controversy of potential gene flaws in iPS cells, we derived and established mouse HO-1 knockout ESC lines from HO-1 knockout blastocysts...
November 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/29214717/bisphenol-a-is-an-exogenous-toxin-that-promotes-mitochondrial-injury-and-death-in-tubular-cells
#6
Enrique Bosch-Panadero, Sebastian Mas, Esther Civantos, Pedro Abaigar, Vanesa Camarero, Alberto Ruiz-Priego, Alberto Ortiz, Jesus Egido, Emilio González-Parra
BACKGROUND: Uremic toxins that accumulate in chronic kidney disease (CKD) contribute to CKD complications, such as CKD progression. Bisphenol A (BPA) is a ubiquitous environmental toxin, structurally related with p-cresol, that accumulates in CKD. Our aim was to characterize the nephrotoxic potential of BPA. Specifically, we addressed BPA toxicity over energy-demanding proximal tubular cells. METHODS: Cell death and oxidative stress were evaluated by flow cytometry and confocal microscopy in HK-2 human proximal tubular epithelial cells...
December 7, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29212810/heme-oxygenase-1-is-a-potent-inhibitor-of-placental-ischemia-mediated-endothelin-1-production-in-cultured-human-glomerular-endothelial-cells
#7
Bhavisha A Bakrania, Frank T Spradley, Simon C Satchell, David E Stec, John M Rimoldi, Rama S V Gadepalli, Joey P Granger
Preeclampsia is a pregnancy-specific disorder of maternal hypertension and reduced renal hemodynamics linked to reduced endothelial function. Placental ischemia is thought to be the culprit of this disease, as it causes the release of factors like tumor necrosis factor (TNF)-α that induce vascular endothelin-1 (ET-1) production. Interestingly, placental ischemia-induced hypertension in rats (reduced uterine perfusion pressure, RUPP model) is abolished by ETA receptor blockade, suggesting a critical role for ET-1...
December 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29209333/inhibition-of-acute-graft-versus-host-disease-with-retention-of-graft-versus-tumor-effects-by-dimethyl-fumarate
#8
Jingjing Han, Shoubao Ma, Huanle Gong, Shuangzhu Liu, Lei Lei, Bo Hu, Yang Xu, Haiyan Liu, Depei Wu
Acute graft-versus-host disease (aGVHD) remains a clinical challenge and a major source of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Dimethyl fumarate (DMF), an activator of Nrf2, has been shown to have anti-inflammatory and immunomodulatory properties without significant immunosuppression. We therefore hypothesized that DMF could be potentially harnessed for the treatment of aGVHD with retention of graft-versus-tumor effect. In this study, we showed that DMF significantly inhibited alloreactive T cell responses in vitro in mixed lymphocyte reaction assay...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29209167/heme-oxygenase-1-induction-by-carbon-monoxide-releasing-molecule-3-suppresses-interleukin-1%C3%AE-mediated-neuroinflammation
#9
Chih-Chung Lin, Chien-Chung Yang, Li-Der Hsiao, Ssu-Yu Chen, Chuen-Mao Yang
Neurodegenerative disorders and brain damage are initiated by excessive production of reactive oxygen species (ROS), which leads to tissue injury, cellular death and inflammation. In cellular anti-oxidant systems, heme oxygenase-1 (HO-1) is an oxidative-sensor protein induced by ROS generation or carbon monoxide (CO) release. CO releasing molecules (CORMs), including CORM-3, exert anti-oxidant and anti-inflammatory effects. However, the molecular mechanisms of CORM-3-induced HO-1 expression and protection against interleukin (IL)-1β-induced inflammatory responses have not been fully elucidated in rat brain astrocytes (RBA-1)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29208364/dopamine-promotes-cellular-iron-accumulation-and-oxidative-stress-responses-in-macrophages
#10
Stefanie Dichtl, David Haschka, Manfred Nairz, Markus Seifert, Chiara Volani, Oliver Lutz, Günter Weiss
Iron is essential for many biological functions including neurotransmitter synthesis, where the metal is a co-factor of tyrosine hydroxylase, which converts tyrosine to dopamine and further to norepinephrine. As the shared chemical structure, called catechol, may potentially bind iron we questioned whether tyrosine derived hormones would impact on cellular iron homeostasis in macrophages, which are central for the maintenance of body iron homeostasis. Using murine bone marrow-derived macrophages (BMDMs), we investigated the effect of catecholamines and found that only dopamine but neither tyrosine, nor norepinephrine, affected cellular iron homeostasis...
December 2, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29203625/fetal-microsatellite-in-the-heme-oxygenase-1-promoter-is-associated-with-severe-and-early-onset-preeclampsia
#11
Tea Kaartokallio, Siddheshwar Utge, Miira M Klemetti, Jussi Paananen, Kari Pulkki, Jarkko Romppanen, Ilkka Tikkanen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Päivi Lakkisto, Hannele Laivuori
Preeclampsia is a vascular pregnancy disorder that often involves impaired placental development. HO-1 (heme oxygenase 1, encoded by HMOX1) is a stress response enzyme crucial for endothelial and placental function. Long version of the guanine-thymine (GTn) microsatellite in the HMOX1 promoter decreases HO-1 expression, and the long maternal repeat is associated with late-onset preeclampsia. Our aim was to study whether the length of fetal repeat is associated with mother's preeclampsia, whether the length of fetal and maternal repeats affect HO-1 levels in placenta and maternal serum, and whether HO-1 levels are altered in preeclampsia...
December 4, 2017: Hypertension
https://www.readbyqxmd.com/read/29203449/dietary-leucine-modulates-growth-performance-nrf2-antioxidant-signaling-pathway-and-immune-response-of-juvenile-blunt-snout-bream-megalobrama-amblycephala
#12
Hualiang Liang, Ahmed Mokrani, Ke Ji, Xianping Ge, Mingchun Ren, Jun Xie, Bo Liu, Bingwen Xi, Qunlan Zhou
The present study assessed the effects of dietary leucine on growth performance, antioxidant status and immunity in juvenile blunt snout bream. Fish were fed six practical diets of graded leucine levels ranging from 0.90% to 2.94% of dry basis for 8 weeks. Trail results showed that compared to control group (0.90%), 1.72% dietary leucine level significantly improved final weight (FW), weight gain rate (WG) and specific growth rate (SGR), and significantly lowered feed conversion ratio (FCR). Based on WG and SGR, the optimal dietary leucine level was obtained at 1...
December 1, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29203367/cross-talk-between-hydrogen-sulfide-and-carbon-monoxide-in-the-mechanism-of-experimental-gastric-ulcers-healing-regulation-of-gastric-blood-flow-and-accompanying-inflammation
#13
Marcin Magierowski, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Marcin Surmiak, Zbigniew Sliwowski, Mateusz Wierdak, Slawomir Kwiecien, Anna Chmura, Tomasz Brzozowski
Hydrogen sulfide (H2S) and carbon monoxide (CO) exert gastroprotection against acute gastric lesions. We determined the cross-talk between H2S and CO in gastric ulcer healing process and regulation of gastric blood flow (GBF) at ulcer margin. Male Wistar rats with acetic acid-induced gastric ulcers were treated i.g. throughout 9 days with vehicle (control), NaHS (0.1-10 mg/kg) +/- zinc protoporphyrin (ZnPP, 10 mg/kg), D,L-propargylglycine (PAG, 30 mg/kg), CO-releasing CORM-2 (2.5 mg/kg) +/- PAG. GBF was assessed by laser flowmetry, ulcer area was determined by planimetry/histology...
December 1, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29202856/sulfosuccinimidyl-oleate-sodium-is-neuroprotective-and-alleviates-stroke-induced-neuroinflammation
#14
Hiramani Dhungana, Mikko T Huuskonen, Merja Jaronen, Sighild Lemarchant, Humair Ali, Velta Keksa-Goldsteine, Gundars Goldsteins, Katja M Kanninen, Jari Koistinaho, Tarja Malm
BACKGROUND: Ischemic stroke is one of the main causes of death and disability worldwide. It is caused by the cessation of cerebral blood flow resulting in the insufficient delivery of glucose and oxygen to the neural tissue. The inflammatory response initiated by ischemic stroke in order to restore tissue homeostasis in the acute phase of stroke contributes to delayed brain damage. METHODS: By using in vitro models of neuroinflammation and in vivo model of permanent middle cerebral artery occlusion, we demonstrate the neuroprotective and anti-inflammatory effects of sulfosuccinimidyl oleate sodium (SSO)...
December 4, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29202300/dihydrofisetin-exerts-its-anti-inflammatory-effects-associated-with-suppressing-erk-p38-mapk-and-heme-oxygenase-1-activation-in-lipopolysaccharide-stimulated-raw-264-7-macrophages-and-carrageenan-induced-mice-paw-edema
#15
Kai Kai Li, Shan Shan Shen, Xiangyi Deng, Hoi Ting Shiu, Wing Sum Siu, Ping Chung Leung, Chun Hay Ko, Bao Hui Cheng
Dihydrofisetin is a flavanonol derived from some edible wild herbs and traditional Chinese medicines. It has been found to possess many biological activities. However, the anti-inflammatory potential of Dihydrofisetin remains uncharacterized. The aim of the present study was to investigate the anti-inflammatory activity of Dihydrofisetin and its underlying mechanisms. We found that Dihydrofisetin dose-dependently inhibited lipopolysaccharide-induced productions of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264...
December 1, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29201224/expression-of-nf-e2-related-factor-2-in-a-rat-dural-arteriovenous-fistula-model
#16
Limin Dou, Wenhua Yu
Intracranial dural arteriovenous fistulas (DAVFs) are complex intracranial vascular malformations that may lead to hemorrhage. Although the precise mechanisms by which DAVFs occur remain unknown, dural angiogenesis may be a vital factor in its pathogenesis. Nuclear factor erythroid 2-related factor 2 (Nrf2) significantly influences angiogenesis; however, the association between DAVF and Nrf2 remains unclear. Therefore, the present study investigated whether DAVF alters the expression of Nrf2 in an experimental animal model of DAVF...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201196/lycium-barbarum-polysaccharide-protects-against-neurotoxicity-via-the-nrf2-ho-1-pathway
#17
Shumei Cao, Jianlong Du, Qiaohong Hei
The incidence of neurodegenerative diseases including Alzheimer's and Parkinson's disease has markedly increased over the past few decades. Oxidative stress is considered to be a common pathophysiological condition resulting in neurotoxicity. Lycium barbarum polysaccharide (LBP) is the major active component of Lycium barbarum L., which exhibit potent antioxidant activity. The current study investigated the neuroprotective effects of LBP in H2O2-treated PC12 cells in vitro and in CoCl2-treated rats in vivo...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29193412/role-of-resveratrol-in-regulation-of-cellular-defense-systems-against-oxidative-stress
#18
REVIEW
Van-Long Truong, Mira Jun, Woo-Sik Jeong
Resveratrol, a natural polyphenolic compound, is found in various kinds of fruits, plants, and their commercial products such as red wine. It has been demonstrated to exhibit a variety of health-promoting effects including prevention and/or treatment of cardiovascular diseases, inflammation, diabetes, neurodegeneration, aging, and cancer. Cellular defensive properties of resveratrol can be explained through its ability of either directly neutralizing reactive oxygen species/reactive nitrogen species (ROS/RNS) or indirectly upregulating the expression of cellular defensive genes...
November 28, 2017: BioFactors
https://www.readbyqxmd.com/read/29193259/lipopolysaccharide-levels-adherent-to-pm2-5-play-an-important-role-in-particulate-matter-induced-immunosuppressive-effects-in-mouse-splenocytes
#19
Cuiying He, Yuan Song, Takamichi Ichinose, Miao He, Kentaro Morita, Duo Wang, Tamotsu Kanazawa, Yasuhiro Yoshida
Epidemiological studies show that exposure to ambient particulate matter (PM) is associated with serious adverse health effects, including, but not limited to, those on the respiratory system. In the present study, we investigated the splenic response in mice administered PM of ≤ 2.5 μ m diameter (PM2.5). Male BALB/c mice (7 or 8 weeks old) were intratracheally administered PM2.5 (0.1 mg) four times, at 2 week intervals, and dissected 24 h after the final administration. The effect of six types of PM2...
November 29, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29191728/the-sp2-iminosugar-glycolipid-1-dodecylsulfonyl-5n-6o-oxomethylidenenojirimycin-dso2-onj-as-selective-anti-inflammatory-agent-by-modulation-of-hemeoxygenase-1-in-bv-2-microglial-cells-and-retinal-explants
#20
Elena Alcalde-Estévez, Ana I Arroba, Elena M Sánchez-Fernández, Carmen Ortiz Mellet, Jose M García Fernández, Laura Masgrau, Ángela M Valverde
Neuroinflammation is an early event during diabetic retinopathy (DR) that impacts the dynamics of microglia polarization. Gliosis is a hallmark of DR and we have reported the beneficial effects of 1R-DSO-ONJ, a member of the sp2-iminosugar glycolipid (sp2-IGL) family, in targeting microglia and reducing gliosis in diabetic db/db mice. Herein, we analyzed the effect of DSO2-ONJ, another family compound incorporating a sulfone group that better mimics the phosphate group of phosphatidylinositol ether lipid analogues (PIAs), in Bv...
November 27, 2017: Food and Chemical Toxicology
keyword
keyword
33467
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"