keyword
MENU ▼
Read by QxMD icon Read
search

ASCO

keyword
https://www.readbyqxmd.com/read/29791286/metastatic-pancreatic-cancer-asco-clinical-practice-guideline-update
#1
Davendra P S Sohal, Erin B Kennedy, Alok Khorana, Mehmet S Copur, Christopher H Crane, Ignacio Garrido-Laguna, Smitha Krishnamurthi, Cassadie Moravek, Eileen M O'Reilly, Philip A Philip, Ramesh K Ramanathan, Joseph T Ruggiero, Manish A Shah, Susan Urba, Hope E Uronis, Michelle W Lau, Daniel Laheru
Purpose In 2016, ASCO published a guideline to assist in clinical decision making in metastatic pancreatic cancer for initial assessment after diagnosis, first- and second-line treatment options, palliative and supportive care, and follow-up. The purpose of this update is to incorporate new evidence related to second-line therapy for patients who have experienced disease progression or intolerable toxicity during first-line therapy. Methods ASCO convened an Expert Panel to conduct a systematic review of the literature on second-line therapy published between June 2015 and January 2018...
May 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29787356/selection-of-optimal-adjuvant-chemotherapy-and-targeted-therapy-for-early-breast-cancer-asco-clinical-practice-guideline-focused-update
#2
Neelima Denduluri, Mariana Chavez-MacGregor, Melinda L Telli, Andrea Eisen, Stephanie L Graff, Michael J Hassett, Jamie N Holloway, Arti Hurria, Tari A King, Gary H Lyman, Ann H Partridge, Mark R Somerfield, Maureen E Trudeau, Antonio C Wolff, Sharon H Giordano
Purpose To update key recommendations of the ASCO guideline adaptation of the Cancer Care Ontario guideline on the selection of optimal adjuvant chemotherapy regimens for early breast cancer and adjuvant targeted therapy for breast cancer. Methods An Expert Panel conducted targeted systematic literature reviews guided by a signals approach to identify new, potentially practice-changing data that might translate to revised practice recommendations. Results The Expert Panel reviewed phase III trials that evaluated adjuvant capecitabine after completion of standard preoperative anthracycline- and taxane-based combination chemotherapy by patients with early-stage breast cancer HER2-negative breast cancer with residual invasive disease at surgery; the addition of 1 year of adjuvant pertuzumab to combination chemotherapy and trastuzumab for patients with early-stage, HER2-positive breast cancer; and the use of neratinib as extended adjuvant therapy for patients after combination chemotherapy and trastuzumab-based adjuvant therapy with early-stage, HER2-positive breast cancer...
May 22, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29784734/new-nccn-guidelines-recognition-and-management-of-immunotherapy-related-toxicity
#3
John A Thompson
Immune checkpoint inhibitors (ICIs) are now FDA-approved for the treatment of 8 different cancers, and more approvals are likely, including use of these drugs in combinations. Although ICIs represent a true advance in cancer care, they can cause a range of immune-related adverse events. As more experience with ICIs is gained, more information is becoming available on immunotoxicity and optimal management. Physicians and patients need to be educated about potential adverse events and management of ICI-associated toxicity...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29782209/practical-assessment-and-management-of-vulnerabilities-in-older-patients-receiving-chemotherapy-asco-guideline-for-geriatric-oncology
#4
Supriya G Mohile, William Dale, Mark R Somerfield, Mara A Schonberg, Cynthia M Boyd, Peggy S Burhenn, Beverly Canin, Harvey Jay Cohen, Holly M Holmes, Judith O Hopkins, Michelle C Janelsins, Alok A Khorana, Heidi D Klepin, Stuart M Lichtman, Karen M Mustian, William P Tew, Arti Hurria
Purpose To provide guidance regarding the practical assessment and management of vulnerabilities in older patients undergoing chemotherapy. Methods An Expert Panel was convened to develop clinical practice guideline recommendations based on a systematic review of the medical literature. Results A total of 68 studies met eligibility criteria and form the evidentiary basis for the recommendations. Recommendations In patients ≥ 65 years receiving chemotherapy, geriatric assessment (GA) should be used to identify vulnerabilities that are not routinely captured in oncology assessments...
May 21, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29781323/targeting-the-b-cell-receptor-pathway-a-review-of-current-and-future-therapies-for-non-hodgkin-s-lymphoma
#5
Thomas D Rodgers, Patrick M Reagan
The B-cell receptor (BCR) pathway is a crucial aspect of mature lymphocytes and is maintained in B-cell neoplasms. Many small module inhibitors targeting kinases within the BCR pathway are approved, with others in development, offering alternative treatment options to standard chemoimmunotherapy. Areas Covered: This review covers both approved inhibitors and investigational inhibitors of spleen tyrosine kinase (SYK), Bruton's tyrosine kinase (BTK), and phosphoinositide-3-kinase (PI3K) in the treatment of B-cell lymphomas...
May 20, 2018: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/29768110/fertility-preservation-in-patients-with-cancer-asco-clinical-practice-guideline-update-summary
#6
Kutluk Oktay, Brittany E Harvey, Alison W Loren
No abstract text is available yet for this article.
May 16, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29764595/-advances-in-antiangiogenic-treatment-of-advanced-non-squamous-non-small-cell-lung-cancer-in-2017-asco-and-wclc
#7
Lianfang Ni, Ligong Nie
No abstract text is available yet for this article.
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29758480/analytical-and-clinical-performance-of-progesterone-receptor-antibodies-in-breast-cancer
#8
Benjamin C Calhoun, Brian Mosteller, Daniel Warren, Margie Smith, J Jordi Rowe, Christopher P Lanigan, Karen C Mrazeck, Espen Walker, Amy Hanlon Newell, Raymond Jones
OBJECTIVE: Comparison of analytical and immunohistochemical performance of progesterone receptor (PR) antibodies with correlation to recurrence of invasive breast cancer treated with endocrine therapy. METHODS: The binding-affinity kinetics of PR clones 1E2, 1A6, 16 and 636 were compared using synthetic peptides derived from identified epitopes on a Biacore T200. A cohort of 351 cases (Hormone Receptor (HR)+/HER2-) were stained for PR expression with immunohistochemistry (IHC) and scored according to ASCO/CAP criteria...
February 27, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29728277/breast-cancer-in-pregnant-patients-a-review-of-the-literature
#9
María Teresa Martínez, Begoña Bermejo, Cristina Hernando, Valentina Gambardella, Juan Miguel Cejalvo, Ana Lluch
Breast cancer diagnosed during pregnancy is a rare occurrence at present; however, in recent years a trend towards delayed childbirth is generating an increase in its incidence. This situation requires a multidisciplinary approach involving obstetricians, oncologists and surgeons. In this review we analyse diagnostic methods, different possible treatments and long-term patient prognosis. We conducted a search for articles published in PubMed, or in abstract form from the San Antonio Breast Cancer Symposium (SABCS), the European Society for Medical Oncology (ESMO), and the American Society of Clinical Oncology (ASCO) annual meeting, using the search terms: "Breast cancer and pregnancy"...
April 23, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29723432/intercepting-a-transient-phosphino-arsinidene
#10
Jose Manuel Goicoechea, Alexander Hinz, Max Hansmann, Guy Bertrand
A phosphino-arsinidene derived from a diazaphospholidine scaffold (Ar**NCH2)2PAs (where Ar** = 2,6-bis[(4-tert-butylphenyl)methyl]-4-methylphenyl) was generated in situ and trapped with a range of reagents. Metathesis reactions between (Ar**NCH2)2PCl and either [Na(18-crown-6)][AsCO] or [Na(dioxane)x][AsCO] are believed to afford an arsaketene, (Ar**NCH2)2PAsCO, which readily loses carbon monoxide under ambient conditions. The resulting transient arsinidene was shown to undergo cycloaddition reactions with excess AsCO-, but can be stabilised in the presence of Lewis bases...
May 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29702501/the-latest-consensus-on-antiemetics
#11
Jørn Herrstedt
PURPOSE OF REVIEW: The present review summarizes and discuss the most recent updated antiemetic consensus. RECENT FINDINGS: Two new neurokinin (NK)1-receptor antagonists, netupitant and rolapitant, have been approved by the Food and Drug Administration and the European Medicines Agency and incorporated in the latest versions of the MASCC/ESMO, ASCO, and NCCN guidelines. Guidelines all recommend a combination of a serotonin (5-HT)3-receptor antagonist, dexametha-sone, and a NK1-receptor antagonist in patients receiving highly emetogenic chemotherapy (HEC) with the addition of the multireceptor targeting agent, olanzapine, as an option in cisplatin or anthracycline-cyclophosphamide chemotherapy...
April 26, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29682662/from-zinco-ii-arsaketenes-to-silylene-stabilised-zinco-arsinidene-complexes
#12
Ernesto Ballestero-Martínez, Terrance J Hadlington, Tibor Szilvási, Shenglai Yao, Matthias Driess
The decarbonylation of the first zinco(ii) arsaketene complexes LZnAsCO (2) and LZn(AsCO)(NHC) (4) (L = {CH(CMeNDipp)2}-, Dipp = 2,6-iPr2C6H3; NHC = [C(Me)N(iPr)]2C:) has been investigated in the presence of the N-heterocyclic silylenes, tBuNHSi (tBuNHSi = [C(H)N(tBu)]2Si:) and DippNHSi (DippNHSi = [C(H)N(2,6-iPr2-C6H3)]2Si:). Depending on the steric demand of the NHSi donor, dimers or monomers of silylene-stabilised arsinidenes are isolated. The bonding situations in all of the novel arsinidene complexes have been elucidated through X-ray diffraction analyses and theoretical calculations...
April 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29681013/the-effects-of-an-educational-program-for-non-physician-health-care-providers-regarding-fertility-preservation
#13
Emi Takeuchi, Masashi Kato, Kayoko Miyata, Nao Suzuki, Chikako Shimizu, Hiroshi Okada, Naoko Matsunaga, Mariko Shimizu, Natsuko Moroi, Daisuke Fujisawa, Masaru Mimura, Yoko Miyoshi
PURPOSE: The American Society of Clinical Oncology (ASCO) Clinical Practice guidelines recommend that physicians, nurses, social workers, and other health care providers should be prepared to discuss the risk of infertility with patients. We conducted an educational program for non-physician health care providers regarding fertility preservation and evaluated the effects of the educational program. METHODS: The 4-h educational program consisted of lectures about infertility as a potential risk of cancer treatment, fertility preservation, and psychosocial support...
April 21, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29676949/supporting-the-future-of-the-oncology-workforce-asco-medical-student-and-trainee-initiatives
#14
Robert A Leon-Ferre, Daniel G Stover
No abstract text is available yet for this article.
April 20, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29648922/reducing-wait-time-between-admission-and-chemotherapy-initiation
#15
Arjun Gupta, Jenny Li, Bernard Tawfik, Thao Pham, Sudarshan Pathak, Prabhjyot Singh, Esmaeil Porsa, Navid Sadeghi, Hsiao C Li
PURPOSE: Reducing the length of stay is a high-priority objective for all health care institutions. Delays in chemotherapy initiation for planned preadmissions lead to patient dissatisfaction and prolonged length of stay. PATIENTS AND METHODS: A multidisciplinary team was formed as part of the ASCO Quality Training Program. We aimed to reduce the time to initiation of chemotherapy from patient arrival at Parkland Hospital from a median of 6.2 hours at baseline to 4 hours over a 6-month period (35% reduction)...
April 12, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29648921/optimizing-anticancer-therapy-in-metastatic-non-castrate-prostate-cancer-asco-clinical-practice-guideline-summary
#16
Michael J Morris, R Bryan Rumble, Matthew I Milowsky
No abstract text is available yet for this article.
April 12, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29628787/molecular-profiling-of-tumours-for-precision-oncology-high-hopes-versus-reality
#17
REVIEW
Sergiusz Nawrocki
Treatment based on molecular profiling of tumor is advertised however there are very limited clinical data supporting this approach so far. Only one, relatively small, randomized clinical trial (SHIVA) have not met its primary endpoint - prolongation of PFS. Some other unpublished series were reported during ASCO 2017 and are discussed in this review. There are many issues to be resolved before the tumor profiling will enter the clinical practice with significant benefit for patients, eg. spatial and temporal heterogeneity of tumor cells in individual patient, wide access to targeted therapies, toxicity of combined targeted therapies...
March 2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29622406/in-the-wake-of-the-2017-asco-meetings-the-surgical-strategy-for-ovarian-cancer-remains-on-track
#18
EDITORIAL
R Villet
No abstract text is available yet for this article.
April 2, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29621291/fungal-community-profiles-in-agricultural-soils-of-a-long-term-field-trial-under-different-tillage-fertilization-and-crop-rotation-conditions-analyzed-by-high-throughput-its-amplicon-sequencing
#19
Loreen Sommermann, Joerg Geistlinger, Daniel Wibberg, Annette Deubel, Jessica Zwanzig, Doreen Babin, Andreas Schlüter, Ingo Schellenberg
Fungal communities in agricultural soils are assumed to be affected by soil and crop management. Our intention was to investigate the impact of different tillage and fertilization practices on fungal communities in a long-term crop rotation field trial established in 1992 in Central Germany. Two winter wheat fields in replicated strip-tillage design, comprising conventional vs. conservation tillage, intensive vs. extensive fertilization and different pre-crops (maize vs. rapeseed) were analyzed by a metabarcoding approach applying Illumina paired-end sequencing of amplicons generated by two recently developed primer pairs targeting the two fungal Internal Transcribed Spacer regions (ITS1, ITS2)...
2018: PloS One
https://www.readbyqxmd.com/read/29620997/fertility-preservation-in-patients-with-cancer-asco-clinical-practice-guideline-update
#20
Kutluk Oktay, Brittany E Harvey, Ann H Partridge, Gwendolyn P Quinn, Joyce Reinecke, Hugh S Taylor, W Hamish Wallace, Erica T Wang, Alison W Loren
Purpose To provide current recommendations about fertility preservation for adults and children with cancer. Methods A systematic review of the literature published from January 2013 to March 2017 was completed using PubMed and the Cochrane Library. An Update Panel reviewed the identified publications. Results There were 61 publications identified and reviewed. None of these publications prompted a significant change in the 2013 recommendations. Recommendations Health care providers should initiate the discussion on the possibility of infertility with patients with cancer treated during their reproductive years or with parents/guardians of children as early as possible...
April 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
keyword
keyword
33466
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"