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https://www.readbyqxmd.com/read/28642131/mir-217-suppresses-proliferation-and-promotes-apoptosis-in-cardiac-myxoma-by-targeting-interleukin-6
#1
Jing Zhang, Cui Wang, Huimin Xu
Cardiac myxoma (CM) is a prevalent primary cardiac tumor. miR-217 plays a vital role in tumorigenesis of various cancers, however, its role and underlying molecular mechanism in human CM remain poorly understood. Here, we reported that the expression of miR-217 was downregulated in CM tissues and inversely correlated with the expression of Interleukin-6 (IL-6) mRNA. Gain-of-function analysis indicated that overexpression of miR-217 inhibited the proliferation and promoted the apoptosis of the primary CM cells...
June 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28641192/obstructive-neonatal-atrial-myxoma
#2
Federica Iezzi, Andrea Quarti, Alessandro Capestro, Marco Pozzi
INTRODUCTION: Cardiac myxoma is a benign neoplasm representing the most common primary cardiac tumor in adults, however it is unusual in neonates. It is represented by an endocardial mass that occupies the cardiac chamber. Although the majority of myxomas are attached to the fossa ovalis of the interatrial septum, they also attach to the walls of the cardiac chambers and to valve leaflets surfaces. Approximately 75% of myxomas are found in the left atrium, 20% are located in the right atrium, and rarely in the ventricles...
June 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28608487/intramuscular-myxoma-and-fibrous-dysplasia-of-bone-presents-as-mazabraud-s-syndrome
#3
Benny Yau, Hock W Kua, Michael F Lo
No abstract text is available yet for this article.
June 13, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28607569/huge-mass-in-right-side-of-the-heart-a-rare-case-report
#4
Reza Ghasemi, Fahimeh Ghanei-Motlagh, Susan Nazari, Mohsen Yaghubi
BACKGROUND: The presence of primary intracardiac tumors are scarce, and most of them are myxomas. We reported, in this paper, a case with huge mass in the right side of the heart. CASE REPORT: A 45-year-old man, with a complaint of bilateral lower limbs edema and exertional dyspnea, was admitted to intensive cardiac care unit. Cardiac auscultation revealed soft grade systolic murmur without any evidence of "tumor plop." Echocardiography showed a huge mobile mass in right side of the heart that suggested myxoma...
November 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28598054/right-atrial-myxoma
#5
Varun Nivargi, Manuel Durairaj, Chandrashekhar Makhale
No abstract text is available yet for this article.
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28597929/next-generation-sequencing-of-oncogenes-and-tumor-suppressor-genes-in-odontogenic-myxomas
#6
Jean Nunes Dos Santos, Ernesto Santos Sousa Neto, Josiane Alves França, Marina Gonçalves Diniz, Rennan Garcias Moreira, Wagner Henriques Castro, Ricardo Santiago Gomez, Silvia Ferreira de Sousa, Carolina Cavalieri Gomes
BACKGROUND: Mutations previously considered drivers of malignant neoplasms also occur in benign tumors. From the biological perspective, the study of malignant and benign neoplasms is equally relevant. The study of rare tumors contributes to the understanding of the more common ones, as both could share the same hallmark genetic drivers. The identification of driver mutations in benign tumors is facilitated by the fact that they harbor quiet genomes. Pathogenic mutations have being described in benign epithelial odontogenic tumors, such as ameloblastomas and adenomatoid odontogenic tumors...
June 8, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28592535/newcastle-disease-virus-establishes-persistent-infection-in-tumor-cells-in-vitro-contribution-of-the-cleavage-site-of-fusion-protein-and-second-sialic-acid-binding-site-of-hemagglutinin-neuraminidase
#7
Udaya S Rangaswamy, Weijia Wang, Xing Cheng, Patrick McTamney, Danielle Carroll, Hong Jin
Newcastle Disease Virus (NDV) is an oncolytic virus being developed for the treatment of cancer. Following infection of an ovarian human cancer cell line (OVCAR3) with a recombinant low pathogenic NDV, persistent infection (PI) was established in a subset of tumor cells. PI cells exhibited resistance to superinfection with NDV, and an anti-viral state as demonstrated by upregulation of interferon and interferon induced genes such as Myxoma resistance gene 1 (Mx1) and Retinoic acid-inducing gene-I (RIG-I). Viruses released from PI cells induced higher cell to cell fusion following infection compared to the parental virus in two tumor cell lines tested, HT1080 and HeLa, and remained to be attenuated in chickens...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28588867/cardiac-arrest-reveals-a-mobile-large-left-atrial-myxoma
#8
Emmanouel Papadakis, Ilias Vournas, Meletios A Kanakis
Left atrial myxoma could be a rare cause of cardiac arrest as this mass could impinge on the mitral orifice causing left ventricular inflow tract obstruction.
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28582370/isolated-neurofibroma-of-the-orbit-case-report-and-literature-review
#9
Puneet S Braich, Jared C Donaldson, Gurtej S Bajaj, William H Bearden
PURPOSE: To summarize the clinical, radiographic, and intraoperative characteristics of isolated neurofibromas of the orbit (INFO) in the literature and report a case of INFO. METHODS: Case report and a systematic review of the literature. RESULTS: A total of 45 patients were identified from 18 previous studies. There was no sex predilection and mean ages were between 32.3 and 40.0 years with a standard deviation of 9.8 to 19.5 years, median age was 32 to 38 years with a range of 1...
June 2, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28579859/clot-in-lung-clot-in-heart-a-case-report-of-tumor-like-thrombus-in-right-atrium
#10
Roshanak Habibi, Alvaro J Altamirano, Shahriar Dadkhah
Tumor-like formation of thrombus in the right atrial cavity is rare. It may be mistaken for a myxoma. The exact pathophysiology of an isolated thrombus in the heart is still unclear. Management to prevent complications such as pulmonary thromboembolism depends on the clinical judgment of a cardiologist. This report describes a 76-year-old woman with right atrial thrombus causing subsequent pulmonary thromboembolism in right lung. She initially presented to us with pulmonary embolism, and later, an incidental finding of a mass in her right atrium revealed an association of thrombus in heart with thrombus in lung...
2017: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/28574050/-haemangioma-of-the-left-atrium
#11
A Sh Revishvili, V A Popov, A N Korostelev, M V Il'ina, A L Goloviuk, D V Kalinin
Presented herein is a clinical case report concerning successful surgical management of a rare variety of a primary tumour of the heart, i. e., a capillary haemangioma of the left atrium, simulating by the contours and localization a myxoma. The final diagnosis was verified only by histological examination. The authors describe difficulties of diagnosis of the disease involved, underlying the necessity of plastic correction for restoration of the normal anatomical configuration of the heart. This is followed by a review of the literature, reflecting a possible course of the disease, problems of diagnosis, and therapeutic policy...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28573796/massive-left-atrial-myxoma-induced-congestive-heart-failure
#12
Michele Gallo, Jaimin R Trivedi, Adam N Protos, Mark S Slaughter
No abstract text is available yet for this article.
June 1, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28570006/primary-conjunctival-myxoma-case-series-and-review-of-the-literature
#13
Dolores Ríos Y Valles-Valles, Ivette Hernández-Ayuso, Héctor A Rodríguez-Martínez, Armando Medina-Cruz, Guillermo Salcedo-Casillas, Abelardo A Rodríguez-Reyes
AIMS: Myxomas are benign soft tissue tumors resembling primitive mesenchyme. They rarely involve ocular structures and have been recognized in conjunctiva, eyelids, cornea and orbit. The purpose of this study is to describe the clinicopathological features of 7 patients with primary conjunctival myxoma seen at Dr. Luis Sánchez Bulnes Hospital an ophthalmologic referral center in Mexico City. MATERIALS AND METHODS: We reviewed the clinical, histochemical and immunohistochemical studies of patients with documented myxoma of the conjunctiva diagnosed in our hospital...
June 1, 2017: Histopathology
https://www.readbyqxmd.com/read/28567326/renal-myxoma-an-incidental-finding
#14
Parth Thakker, Tam Ramsey, Fernando Navarro
Myxomas are mesenchymal tumors commonly found in the heart and skin. Renal myxomas are rare, having only been documented 14 times. Our case is a 55-year-old woman who presented to our clinic after a right renal mass was incidentally found on CT. Evaluation with MRI showed a mass that appeared to arise from the supero-medial cortex of the right kidney. As the imaging was concerning for renal cell carcinoma, the patient underwent a partial nephrectomy. Microscopic examination showed a well-circumscribed mass with polygonal to spindle-shaped cells in a granular eosinophilic cytoplasm...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28567309/left-atrial-myxoma-in-pregnancy-management-strategy-using-minimally-invasive-surgical-approach
#15
Noppon Taksaudom, Kuntharee Traisrisilp, Rungsrit Kanjanavanit
This case report concerns a young woman who, during her pregnancy, suffered severe mitral regurgitation. It was discovered at the same time that she had a left atrial myxoma. During the early postpartum period she successfully underwent an anterior minithoracotomy to remove the left atrial myxoma in conjunction with repair of the mitral valve. The thoracotomy approach in this specific patient was chosen as it would give a better chance of successful mother-child bonding because the patient would be able to avoid the precautions which would have been necessary following a sternotomy, especially the limitation of her ability to hold her child during the first 4-6 weeks postoperatively...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28560753/big-thrombus-sitting-in-an-atrial-septal-aneurysm
#16
Julián Vega Adauy, Luigi Gabrielli, Samuel Córdova, Rodrigo Saavedra, Paul McNab
A 79 year-old-man presented three episodes of upper gastrointestinal bleeding and weight loss. Endoscopy revealed bleeding and extrinsic compression at the pyloric region. Computed tomography scan showed a pancreatic tumor, peritoneal carcinomatosis, vascular infiltration, and incidentally found a partially calcified hypodense lesion of 35 mm in the left atrium, suggesting a myxoma or a thrombus. Echocardiography revealed moderate left atrium enlargement, dilated left atrial appendage with spontaneous echo contrast, moderate dilatation and dysfunction of the left ventricle, ejection fraction was 39%, and an atrial septal aneurysm in which a piriform, mass of 35×33×25 mm, was "sitting," suggesting an organized thrombus...
May 30, 2017: Echocardiography
https://www.readbyqxmd.com/read/28558359/large-scale-assessment-of-myxomatosis-prevalence-in-european-wild-rabbits-oryctolagus-cuniculus-60years-after-first-outbreak-in-spain
#17
Rafael Villafuerte, Francisca Castro, Esther Ramírez, Irene Cotilla, Francisco Parra, Miguel Delibes-Mateos, Pilar Recuerda, Carlos Rouco
Myxomatosis is a viral disease that affects European rabbits (Oryctolagus cuniculus) worldwide. In Spain, populations of wild rabbits drastically decreased in the 1950s after the first outbreak of myxomatosis. Since that first appearance, it seems to be an annual epizootic in Spain with periodic outbreaks, predominantly in summer and autumn. Taking into account rabbit population structure, abundance, and genetic lineage, this paper attempts to make a large-scale characterization of myxomatosis seroprevalence based on the immune status of 29 rabbit populations distributed throughout Spain, where O...
May 18, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28556391/cardiac-myxoma-a-rare-case-series-of-3-patients-and-a-literature-review
#18
Haiyan Wang, Quan Li, Minghua Xue, Pengzhan Zhao, Jing Cui
Myxoma is the most common tumor in the heart. A typical myxoma is relatively straightforward to diagnose. However, certain cardiac myxomas have rare features. We report three extremely rare cases of cardiac myxoma. One case involved a myxoma that originated from the annulus of the tricuspid after valvuloplasty, one case involved myxomas associated with left atrial thrombus and severe mitral stenosis, and the third case involved myxoma combined with severe calcification. All three cases were diagnosed by echocardiography and pathology...
May 27, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28549450/the-left-atrial-bacterial-vegetative-mass-due-to-corynebacterium-striatum-as-a-presentation-of-myxoma-a-case-report
#19
Jun Xu, Qing Yang, Jun Li, Xia Zheng
BACKGROUND: Corynebacterium striatum is a member of the non-diphtherial corynebacteria, which are ubiquitous in nature and generally colonize the skin and mucous membranes of humans. Rarely, it causes infective endocarditis (IE). We report a case of rare left atrial bacterial vegetative mass due to C. striatum masquerading as a myxoma identified through a tortuous diagnostic process, and present a brief review of the relevant literature. CASE PRESENTATION: We present a case of 63-year-old man who presented with progressively worsening dyspnea on exertion and lower leg edema, and was diagnosed with heart failure...
May 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28546884/in-vivo-and-in-situ-programming-of-tumor-immunity-by-combining-oncolytics-and-pd-1-immune-checkpoint-blockade
#20
Eric Bartee, Zihai Li
Blockade of the programmed cell death protein 1 (PD1) pathway is clinically effective against human cancers. Although multiple types of malignancies have been shown to respond to PD1 agents, only a small percentage of patients typically benefit from this treatment. In addition, PD1 therapy often causes serious immune-related adverse events. A recent study demonstrated that local, intra-tumoral, administration of modified oncolytic myxoma virus which expresses a truncated version of the PD1 protein resulted in both increased efficacy and reduced toxicity in a clinically relevant melanoma model...
2017: Experimental Hematology & Oncology
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