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renal IRI

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https://www.readbyqxmd.com/read/29686001/biological-sex-modulates-the-adrenal-and-blood-pressure-responses-to-angiotensin-ii
#1
Mohammad Zaki Shukri, Jia Wei Tan, Worapaka Manosroi, Luminita H Pojoga, Alicia Rivera, Jonathan S Williams, Ellen W Seely, Gail K Adler, Iris Z Jaffe, Richard H Karas, Gordon H Williams, Jose R Romero
The relationship between biological sex and aldosterone on blood pressure (BP) is unclear. We hypothesized that sex would modify the interaction between aldosterone and vascular responses to salt intake and angiotensin II (AngII). To test this hypothesis, in 1592 subjects from the well-controlled Hypertensive Pathotype cohort, we compared responses of women and men to chronic (BP and aldosterone levels in response to dietary salt) and acute (BP, renal plasma flow, and aldosterone responses to AngII infusion) manipulations...
April 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29675795/oral-adsorbent-ast-120-ameliorates-gut-environment-and-protects-against-the-progression-of-renal-impairment-in-ckd-rats
#2
Ayumi Yoshifuji, Shu Wakino, Junichiro Irie, Ayumi Matsui, Kazuhiro Hasegawa, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Itoh
BACKGROUND: Oral charcoal adsorbent AST-120 (AST) is reported to ameliorate renal dysfunction by the absorption of toxic substance in the gut. Recent study revealed that, in CKD, gut environment is disturbed including the decrease in tight junctions and Lactobacillus (Lact). In this study, we examined whether AST improves the renal dysfunction through gut environment. METHOD: Six-week-old spontaneously hypertensive rats (SHR) were rendered CKD by 5/6th nephrectomy (Nx)...
April 19, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29649832/the-impact-of-preexisting-chronic-kidney-disease-on-the-severity-and-recovery-of-acute-kidney-injury
#3
Sung Yoon Lim, Yoon Sook Ko, Hee Young Lee, Ji Hyun Yang, Myung Gyu Kim, Sang Kyung Jo, Won Yong Cho
BACKGROUND: Recent observational studies have shown that in chronic kidney disease (CKD) patients, a significantly smaller percentage of patients with an episode of acute kidney injury (AKI) have full recovery of renal function compared to those without CKD. However, precise mechanisms involved in the incomplete repair after AKI with preexisting CKD have not been completely ascertained. Here, we assessed the impact of preexisting CKD on the severity and recovery of AKI in a mouse model of 5/6 nephrectomy...
April 12, 2018: Nephron
https://www.readbyqxmd.com/read/29608890/ischemic-acute-kidney-injury-and-klotho-in-renal-transplantation
#4
REVIEW
Fatemeh Panah, Amir Ghorbanihaghjo, Hassan Argani, Maryam Asadi Zarmehri, Saeed Nazari Soltan Ahmad
Post-transplant ischemic acute kidney injury (AKI), secondary to ischemia reperfusion injury (IRI), is a major problem influencing on the short and long term graft and patient survival. Many molecular and cellular modifications are observed during IRI, for example, tissue damage result production of reactive oxygen species (ROS), cytokines, chemokines, and leukocytes recruitment which are activated by NF-κB (nuclear factor kappa B) signaling pathway. Therefore, inhibiting these processes can significantly protect renal parenchyma from tissue damage...
March 30, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29582226/a-long-term-feed-supplementation-based-on-phosphate-binders-in-feline-chronic-kidney-disease
#5
E Biasibetti, E Martello, M Bigliati, I Biasato, T Cocca, N Bruni, M T Capucchio
Chronic kidney disease (CKD) is a very common disorder in elderly cats. A proper renal diet represents the most efficient therapeutic intervention to improve survival and life quality in feline patients with 3 and 4 International Renal Interest Society (IRIS) stages. Twenty cats were selected in this study. Ten were administered the dietary supplementation for 360 days and the other ten, whose owners did not give consent for any supplemental therapies apart from the renal diet, were selected from a clinical database and used as control group...
March 26, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29581741/extract-of-rhus-verniciflua-stokes-protects-against-renal-ischemia-reperfusion-injury-by-enhancing-nrf2-mediated-induction-of-antioxidant-enzymes
#6
Du Ri Choi, Ji Heun Jeong, Kwang-Sik Yu, Nam-Seob Lee, Young-Gil Jeong, Do Kyung Kim, Chun Soo Na, Dae Seung Na, Won Min Hwang, Seung-Yun Han
Ischemia-reperfusion injury (IRI) may cause acute kidney disease (AKD) by mediating the oxidative stress-induced apoptosis of parenchymal cells. The extract of Rhus verniciflua Stokes (RVS) is used as a traditional herbal medicine as it exhibits anti-oxidant, anti-apoptotic and anti-inflammatory properties. Therefore, the current study investigated the therapeutic effect and the underlying mechanism of RVS on IRI-induced AKD in vivo and in vitro . The current study assessed the effects of RVS on a mouse model of renal IRI and in hypoxic human renal tubular epithelial HK-2 cells...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29559678/transient-receptor-potential-vanilloid-4-channel-deficiency-aggravates-tubular-damage-after-acute-renal-ischaemia-reperfusion
#7
Marwan Mannaa, Lajos Markó, András Balogh, Emilia Vigolo, Gabriele N'diaye, Mario Kaßmann, Laura Michalick, Ulrike Weichelt, Kai M Schmidt-Ott, Wolfgang B Liedtke, Yu Huang, Dominik N Müller, Wolfgang M Kuebler, Maik Gollasch
Transient receptor potential vanilloid 4 (TRPV4) cation channels are functional in all renal vascular segments and mediate endothelium-dependent vasorelaxation. Moreover, they are expressed in distinct parts of the tubular system and activated by cell swelling. Ischaemia/reperfusion injury (IRI) is characterized by tubular injury and endothelial dysfunction. Therefore, we hypothesised a putative organ protective role of TRPV4 in acute renal IRI. IRI was induced in TRPV4 deficient (Trpv4 KO) and wild-type (WT) control mice by clipping the left renal pedicle after right-sided nephrectomy...
March 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29557914/syndecan-1-shedding-inhibition-to-protect-against-ischemic-acute-kidney-injury-through-hgf-target-signaling-pathway
#8
Zhihui Lu, Nana Song, Bo Shen, XiaLian Xu, Yi Fang, Yiqin Shi, Yichun Ning, Jiachang Hu, Yan Dai, Xiaoqiang Ding, Jianzhou Zou, Jie Teng
BACKGROUND: The hepatocyte growth factor (HGF) target pathway plays pivotal renoprotective roles after acute kidney injury (AKI). Syndecan-1 serves as the co-receptor for HGF. Shedding of syndecan-1 is involved in various pathological processes. Thus, we hypothesized that IRI induced syndecan-1 shedding and inhibiting syndecan-1 shedding would protect against kidney injury by potentiating activation of the HGF receptor c-Met. METHODS: Expression of syndecan-1 and its sheddases were observed in kidneys of sham and I/R mice...
March 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29554974/renal-dialysis-and-long-term-treatment-of-a-dog-with-kidney-disease-associated-with-canine-leishmaniosis
#9
Gad Baneth, Gilad Segev, Michal Mazaki-Tovi, Hila Chen, Sharon Kuzi
BACKGROUND: Renal disease is considered the main cause of natural mortality in dogs with canine leishmaniosis. The pathological mechanisms associated with kidney injury in canine leishmaniosis include immune complex glomerulonephritis, tubulointerstitial nephritis and occasionally renal amyloidosis. Proteinuria is a frequent finding in canine leishmaniosis and its quantification by the urine protein-creatinine ratio (UPC) is an important parameter in the staging of canine lesihmaniosis as presented by the LeishVet group...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29550818/klotho-reduces-necroptosis-by-targeting-oxidative-stress-involved-in-renal-ischemic-reperfusion-injury
#10
Yingying Qian, Xiangjiang Guo, Lin Che, Xuejing Guan, Bei Wu, Renhua Lu, Mingli Zhu, Huihua Pang, Yucheng Yan, Zhaohui Ni, Leyi Gu
BACKGROUND/AIMS: Klotho is a multifunctional protein expressed predominantly in kidney tubular epithelium. Here, we investigated the protective effects of Klotho on necroptosis in renal ischemic-reperfusion injury (IRI) and the role of oxidative stress in this process. METHODS: Mice were subjected to bilateral renal pedicle clamping. Mouse renal tubular epithelial (TCMK-1) cells were exposed to hypoxia/reoxygenation (H/R) or H2O2. Kidney samples from acute kidney injury (AKI) patients and controls were examined by immunofluorescence...
March 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29549575/apparent-diffusion-coefficient-is-a-useful-biomarker-for-monitoring-adipose-derived-mesenchymal-stem-cell-therapy-of-renal-ischemic-reperfusion-injury
#11
Sheung-Fat Ko, Hon-Kan Yip, Chen-Chang Lee, Chia-Chang Lee, Chia-Hao Su, Chung-Cheng Huang, Shu-Hang Ng, Yi-Ling Chen, Min-Chi Chen
PURPOSE: This study aimed to investigate the potential of apparent diffusion coefficient (ADC) for monitoring adipose-derived mesenchymal stem cell (ADMSC) therapy of renal ischemic-reperfusion injury (IRI). PROCEDURES: After baseline magnetic resonance imaging (MRI), 36 Sprague-Dawley rats with bilateral renal IRI were divided equally as groups 1, 2, and 3 (non-treated rats) and groups 4, 5, and 6 (ADMSC-treated rats, with 2 million ADMSCs injected via the tail vein at 6 h after IRI)...
March 16, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29531923/the-role-of-vasodilator-receptors-of-renin-angiotensin-system-on-nitric-oxide-formation-and-kidney-circulation-after-angiotensin-ii-infusion-in-renal-ischemia-reperfusion-rats
#12
Maryam Maleki, Jalal Hasanshahi, Fatemeh Moslemi
Background: Nitric oxide (NO) as a vasodilator factor has renoprotective effect against renal ischemia. The balance between angiotensin II (Ang II) and NO can affect kidney homeostasis. The aim of this study was to determine NO alteration in response to renin-Ang system vasodilator receptors antagonists (PD123319; Ang II type 2 receptor antagonist and A779; Mas receptor antagonist) in renal ischemia/reperfusion injury (IRI) in rats. Materials and Methods: Sixty-three Wistar male and female rats were used...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29513943/a-critical-review-on-pharmacological-significance-of-hydrogen-sulfide-h%C3%A2-s-on-nf-%C3%AE%C2%BAb-concentration-and-icam-1-expression-in-renal-ischemia-reperfusion-injury
#13
Syed Fayaz Hashmp, Munavvar Z A Sattar, Hassaan A Rathore, Ashfaq Ahmadi, Edward J Johns
Until recently hydrogen sulfide (H2S) was the least appreciated of the three gasotransmitters but now recognized as 3Y gaseous mediator after nitric oxide(NO) and carbon monoxide (CO). H2S regulates a number of physiological processes like vasorelaxation, prevention of inflammation, leukocyte adhesion, anti-prolifera- tive effects, anti-thrombotic effects, resistance to oxidative stress and protection against ischemia reperfusion injury (IRI). However, considerable amount of research is still needed to evaluate the mechanisms involved in the therapeutic effects of H2S in IRI such as its effects on nuclear factor-kappa B (NF-KB) concentration and intercellular adhesion molecule-1 (ICAM-1) expression in renal IRI and ARF (acute renal failure)...
May 2017: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/29496081/the-endovascular-management-of-neurofibromatosis-associated-aneurysms-a-systematic-review
#14
David Bargiela, Misha M Verkerk, Ian Wee, Kiera Welman, Eugene Ng, Andrew M T L Choong
BACKGROUND: Neurofibroblastoma (NF) or Von Recklinghausen disease, is an autosomal dominant disorder affecting one in 3000 individuals. Cardinal features of NF include multiple café-au-lait macules, benign neurofibromas, and iris hamartomas. Albeit less common, vascular lesions of medium and large-sized arteries and veins are a well-recognized complication, which can lead to fatal consequences such as rupture. METHOD: A systematic review was conducted as per the Preferred Reporting Instructions for Systematic Reviews and Meta-analysis (PRISMA) guidelines utilizing PubMed, EMBASE, and Cochrane databases...
March 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29490296/resveratrol-alleviates-inflammatory-responses-and-oxidative-stress-in-rat-kidney-ischemia-reperfusion-injury-and-h2o2-induced-nrk-52e-cells-via-the-nrf2-tlr4-nf-%C3%AE%C2%BAb-pathway
#15
Jiawei Li, Long Li, Shuo Wang, Chao Zhang, Long Zheng, Yichen Jia, Ming Xu, Tongyu Zhu, Yi Zhang, Ruiming Rong
BACKGROUND: Ischemia-reperfusion injury (IRI) is one of the major causes of postoperative renal allograft dysfunction, which is mainly the result of proinflammatory reactions including inflammatory responses, oxidative stress, and metabolic disorders. Resveratrol (RSV) plays an important role in protecting various organs in IRI because it reduces oxidative stress, lessens the inflammatory response, and exerts anti-apoptotic effects. The aim of this study was to demonstrate the renoprotective effect of RSV in inhibiting inflammatory responses, reducing oxidative stress, and decreasing cell apoptosis in vivo and in vitro...
February 22, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29480441/a1ar-mediated-renal-protection-against-ischemia-reperfusion-injury-is-dependent-on-hsp27-induction
#16
Bin Xiong, Min Li, Shulin Xiang, Lin Han
PURPOSE: A1 adenosine receptor (AR) activation has been demonstrated to attenuate renal ischemia/reperfusion injury (IRI), but the exact mechanism of this protection remains to be well elucidated. METHODS: Male C57BL/6 mice were used in the present study. Expression of heat shock protein (HSP) 27 and HSF-1 were detected using western blot analysis. An RNA interference with adenovirus vector using short hairpin RNA targeting HSP27 was developed. Together with renal IRI model, indicators of renal function, acute tubular necrosis, inflammation and apoptosis were measured in kidneys after 24-h reperfusion...
February 26, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29466390/the-role-of-complement-activation-in-rhabdomyolysis-induced-acute-kidney-injury
#17
XuDong Huang, Wei Zhao, LiXia Zhang, XinJun Yang, LiHui Wang, YunShuang Chen, JingHua Wang, Chao Zhang, GuangLi Wu
Rhabdomyolysis (RM) may cause kidney damage and results primarily in acute kidney injury (AKI). Complement is implicated in the pathogenesis of renal diseases and ischemia-reperfusion injury (IRI), but the role of complement, especially its activation pathway(s) and its effect in RM-induced AKI, is not clear. This study established a rat model of AKI induced by RM via intramuscular treatment with glycerol. Cobra venom factor (CVF) was administered via tail vein injection to deplete complement 12 h prior to intramuscular injection of glycerol...
2018: PloS One
https://www.readbyqxmd.com/read/29451033/control-release-of-mitochondria-targeted-antioxidant-by-injectable-self-assembling-peptide-hydrogel-ameliorated-persistent-mitochondrial-dysfunction-and-inflammation-after-acute-kidney-injury
#18
Meng Zhao, Yijie Zhou, Shuyun Liu, Lan Li, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Persistent mitochondrial injury occurs after acute kidney injury (AKI) and mitochondria-targeted antioxidant Mito-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) (MT) has shown benefits for AKI, but its efficiency is limited by short half-life and side effect in vivo. Self-assembling peptide (SAP) hydrogel is a robust platform for drug delivery. This study aims to develop an SAP-based carrier to slow release MT for enhancing its long-term therapeutic potency on AKI. The KLD with aspartic acid (KLDD) was designed...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29446739/role-of-complement-properdin-in-renal-ischemia-reperfusion-injury
#19
Zinah Zwaini, Houyong Dai, Cordula Stover, Bin Yang
Renal Ischemia-Reperfusion Injury (IRI) is one of the main causes of Acute Kidney Injury (AKI), and may lead to chronic kidney disease. The high mortality rate of AKI has not changed in the last 5 decades due to non-recognition, nephrotoxin exposure, delayed diagnosis and lack of specific intervention. Complement activation plays important roles in IRI-induced AKI because of its association with immunity, inflammation, cell death and tissue repair. Nevertheless, the role of complement properdin, the sole positive regulator of the alternative pathway, in IRI-induced AKI has not been well defined...
2017: Current Gene Therapy
https://www.readbyqxmd.com/read/29446737/gene-modified-mesenchymal-stem-cell-based-therapy-in-renal-ischemia-reperfusion-injury
#20
Hongbo Xu, Cheng Chen, Linkun Hu, Jianquan Hou
Acute kidney injury (AKI) is a common syndrome in the clinic and has become a worldwide public health problem. Renal ischemia-reperfusion injury (IRI) is the most common cause of AKI. So far, effective treatment is still lacking for renal IRI, resulting in a high mortality rate of AKI. Mesenchymal stem cells (MSCs), considered as a promising candidate for tissue repair and regenerative medicine have aroused an increasing concern in recent years for the capacity of self-renewal and multi-lineage differentiation...
February 13, 2018: Current Gene Therapy
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