keyword
https://read.qxmd.com/read/38530931/imaging-markers-from-population-wide-mri-based-automated-kidney-segmentation-an-analysis-of-data-from-the-german-national-cohort-nako-gesundheitsstudie
#1
Elias Kellner, Peggy Sekula, Jan Lipovsek, Maximilian Russe, Harald Horbach, Christopher L Schlett, Matthias Nauck, Henry Völzke, Thomas Kroencke, Stefanie Bette, Hans-Ulrich Kauczor, Thomas Keil, Tobias Pischon, Iris M Heid, Annette Peters, Thoralf Niendorf, Wolfgang Lieb, Fabian Bamberg, Martin Büchert, Wilfried Reichardt, Marco Reisert, Anna Köttgen
BACKGROUND: Population-wide research on potential new imaging biomarkers of the kidney depends on accurate automated segmentation of the kidney and its compartments (cortex, medulla, and sinus). METHODS: We developed a robust deep-learning framework for kidney (sub-)segmentation based on a hierarchical, three-dimensional convolutional neural network (CNN) that was optimized for multi-scale problems of combined localization and segmentation. We applied the CNN to abdominal magnetic resonance images from the population-based German National Cohort (NAKO) study...
May 3, 2024: Deutsches Ärzteblatt International
https://read.qxmd.com/read/38530256/tolerogenic-cd11c-dendritic-cells-regulate-cd4-tregs-in-replacing-delayed-ischemic-preconditioning-to-alleviate-ischemia-reperfusion-acute-kidney-injury
#2
JOURNAL ARTICLE
Pingping Wang, Chunyao Li, Tao Peng, Longzhu Ruan, Aijie Wu, Jiaojiao Zhu, Wenlu Shi, Menghua Chen, Ting Zhang
Ischemia-reperfusion injury (IRI) is one of the primary clinical causes of acute kidney injury (AKI). The key to IRI lies in immune-inflammatory damage, where dendritic cells (DCs) play a central role in eliciting immune responses within the context of inflammation induced by ischemia-reperfusion. Our previous study has confirmed that delayed ischemic preconditioning (DIPC) can reduce the kidney injury by mediating DCs to regulate T-cells. However, the clinical feasibility of DIPC is limited, as pre-clamping of the renal artery is not applicable for the prevention and treatment of ischemia-reperfusion acute kidney injury (I/R-AKI) in clinical patients...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38529522/a-short-treatment-with-resveratrol-after-a-renal-ischaemia-reperfusion-injury-prevents-maladaptive-repair-and-long-term-chronic-kidney-disease-in-rats
#3
JOURNAL ARTICLE
Miguel Ángel Martínez-Rojas, Hiram Balcázar, María Susana Ponce-Nava, Isaac González-Soria, Brenda Marquina-Castillo, Rosalba Pérez-Villalva, Norma A Bobadilla
Acute kidney injury (AKI) often triggers physiological processes aimed at restoring renal function and architecture. However, this response can become maladaptive, leading to nephron loss and fibrosis. Although the therapeutic effects of resveratrol (RSV) are well established, its impact after AKI and for subsequent chronic kidney disease (CKD) remains unclear. This study assessed whether transient administration of RSV following ischaemia-reperfusion injury (IRI) could prevent the progression to CKD. Forty-one male Wistar rats were assigned randomly to sham surgery, bilateral renal ischaemia for 30 min (IR) or IR+RSV...
March 26, 2024: Journal of Physiology
https://read.qxmd.com/read/38526145/hyaluronidase-inhibitor-sha2-75-alleviates-ischemia-reperfusion-induced-acute-kidney-injury
#4
JOURNAL ARTICLE
Yang Zhang, Huajiang Zhao, Jing Zhang
Hyaluronidases (HAases) are enzymes that degrade hyaluronic acid (HA) in the animal kingdom. The HAases-HA system is crucial for HA homeostasis and plays a significant role in biological processes and extracellular matrix (ECM)-related pathophysiological conditions. This study aims to explore the role of inhibiting the HAases-HA system in acute kidney injury (AKI). We selected the potent inhibitor "sHA2.75" to inhibit HAase activity through mixed inhibitory mechanisms. The ischemia-reperfusion mouse model was established using male BALB/c mice (7-9 weeks old), and animals were subjected to subcapsular injection with 50 mg/kg sHA2...
March 25, 2024: Cell Cycle
https://read.qxmd.com/read/38504554/interleukin-2-anti-interleukin-2-immune-complex-attenuates-cold-ischemia-reperfusion-injury-after-kidney-transplantation-by-increasing-renal-regulatory-t-cells
#5
JOURNAL ARTICLE
Joon Young Jang, Hyung Woo Kim, Ji-Jing Yan, Tae Kyeom Kang, Wook-Bin Lee, Beom Seok Kim, Jaeseok Yang
BACKGROUND: Cold ischemia-reperfusion injury (IRI) is an unavoidable complication of kidney transplantation. We investigated the role of regulatory T cells (Treg) in cold IRI and whether the interleukin (IL)-2/anti-IL-2 antibody complex (IL-2C) can ameliorate cold IRI. METHODS: We developed a cold IRI mouse model using kidney transplantation and analyzed the IL-2C impact on cold IRI in acute, subacute and chronic phases. RESULTS: Treg transfer attenuated cold IRI, while Treg depletion aggravated cold IRI...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38481808/inhibition-of-brd4-attenuates-er-stress-induced-renal-ischemic-reperfusion-injury
#6
JOURNAL ARTICLE
Paula Diaz-Bulnes, Ramon M Rodríguez, Elisenda Banon-Maneus, María Laura Saiz, Cristian Ruiz Bernet, Viviana Corte-Iglesias, Maria Jose Ramirez-Bajo, Marta Lazo-Rodriguez, Isaac Tamargo-Gómez, Raúl R Rodrigues-Diez, Ana B Sanz, Carmen Diaz-Corte, Marta Ruiz-Ortega, Fritz Diekmann, Ana M Aransay, Carlos Lopez-Larrea, Beatriz Suarez-Alvarez
Renal ischemia-reperfusion injury (IRI) leads to endoplasmic reticulum (ER) stress, thereby initiating the unfolded protein response (UPR). When sustained, this response may trigger the inflammation and tubular cell death that acts to aggravate the damage. Here, we show that knockdown of the BET epigenetic reader BRD4 reduces the expression of ATF4 and XBP1 transcription factors under ER stress activation. BRD4 is recruited to the promoter of these highly acetylated genes, initiating gene transcription. Administration of the BET protein inhibitor, JQ1, one hour after renal damage induced by bilateral IRI, reveals reduced expression of ATF4 and XBP1 genes, low KIM-1 and NGAL levels and recovery of the serum creatinine and blood urea nitrogen levels...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38474193/neutrophils-and-nadph-oxidases-are-major-contributors-to-mild-but-not-severe-ischemic-acute-kidney-injury-in-mice
#7
JOURNAL ARTICLE
Csaba Révész, Tamás Kaucsár, Mária Godó, Krisztián Bocskai, Tibor Krenács, Attila Mócsai, Gábor Szénási, Péter Hamar
Upregulation of free radical-generating NADPH oxidases (NOX), xanthine oxidoreductase (XOR), and neutrophil infiltration-induced, NOX2-mediated respiratory burst contribute to renal ischemia-reperfusion injury (IRI), but their roles may depend on the severity of IRI. We investigated the role of NOX, XOR, and neutrophils in developing IRI of various severities. C57BL/6 and Mcl-1ΔMyelo neutrophil-deficient mice were used. Oxidases were silenced by RNA interference (RNAi) or pharmacologically inhibited. Kidney function, morphology, immunohistochemistry and mRNA expression were assessed...
March 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38461333/proteomic-analysis-of-mitochondria-associated-membranes-in-renal-ischemic-reperfusion-injury
#8
JOURNAL ARTICLE
Yi Li, Hua-Bin Wang, Jin-Long Cao, Wen-Jun Zhang, Hai-Long Wang, Chang-Hong Xu, Kun-Peng Li, Yi Liu, Ji-Rong Wang, Hua-Lan Ha, Sheng-Jun Fu, Li Yang
BACKGROUND: The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). Many important cellular functions such as bioenergetics, mitophagy, apoptosis, and calcium signaling are regulated by MAMs, which are thought to be closely related to ischemic reperfusion injury (IRI). However, there exists a gap in systematic proteomic research addressing the relationship between these cellular processes. METHODS: A 4D label free mass spectrometry-based proteomic analysis of mitochondria associated membranes (MAMs) from the human renal proximal tubular epithelial cell line (HK-2 cells) was conducted under both normal (N) and hypoxia/reperfusion (HR) conditions...
March 10, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38453127/lxa4-protected-mice-from-renal-ischemia-reperfusion-injury-by-promoting-irg1-nrf2-and-irak-m-traf6-signal-pathways
#9
JOURNAL ARTICLE
Hongtao Tie, Ge Kuang, Xia Gong, Lidan Zhang, Zizuo Zhao, Shengwang Wu, Wenya Huang, Xiahong Chen, Yinglin Yuan, Zhenhan Li, Hongzhong Li, Li Zhang, Jingyuan Wan, Bin Wang
Excessive inflammatory response and increased oxidative stress play an essential role in the pathophysiology of ischemia/reperfusion (I/R)-induced acute kidney injury (IRI-AKI). Emerging evidence suggests that lipoxin A4 (LXA4), as an endogenous negative regulator in inflammation, can ameliorate several I/R injuries. However, the mechanisms and effects of LXA4 on IRI-AKI remain unknown. In this study, A bilateral renal I/R mouse model was used to evaluate the role of LXA4 in wild-type, IRG1 knockout, and IRAK-M knockout mice...
March 5, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38450510/prior-exposure-to-experimental-preeclampsia-increases-atherosclerotic-plaque-inflammation-in-atherogenic-mice
#10
JOURNAL ARTICLE
Lauren A Biwer, Joshua J Man, Nicholas D Camarda, Brigett V Carvajal, S Ananth Karumanchi, Iris Z Jaffe
BACKGROUND: Women with a history of preeclampsia have evidence of premature atherosclerosis and increased risk of myocardial infarction and stroke compared with women who had a normotensive pregnancy. Whether this is due to common risk factors or a direct impact of prior preeclampsia exposure has never been tested in a mouse atherosclerosis model. METHODS: Pregnant LDLR-KO (low-density lipoprotein receptor knockout; n=35) female mice were randomized in midgestation to sFlt1 (soluble fms-like tyrosine kinase 1)-expressing adenovirus or identical control adenovirus...
March 7, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38442779/international-renal-interest-society-best-practice-consensus-guidelines-for-intermittent-hemodialysis-in-dogs-and-cats
#11
REVIEW
Gilad Segev, Jonathan D Foster, Thierry Francey, Catherine Langston, Ariane Schweighauser, Larry D Cowgill
Intermittent hemodialysis (IHD) is an advanced adjunctive standard of care for severe acute kidney injury (AKI) and other indications. Most animals with AKI are managed medically, however, when the disease is severe, medical management may not control the consequences of the disease, and animals with a potential for renal recovery may die from the consequences of uremia before recovery has occurred. Extracorporeal therapies aid the management of AKI by expanding the window of opportunity for recovery of sufficient kidney function to become dialysis independent...
March 3, 2024: Veterinary Journal
https://read.qxmd.com/read/38439028/inhibition-of-drp1-fis1-interaction-alleviates-aberrant-mitochondrial-fragmentation-and-acute-kidney-injury
#12
JOURNAL ARTICLE
Zhixia Song, Yao Xia, Lang Shi, Hongchu Zha, Jing Huang, Xiaohong Xiang, Huiming Li, Hua Huang, Ruchi Yue, Hongtao Wang, Jiefu Zhu
BACKGROUND: Acute kidney injury (AKI) is a common clinical disorder with complex etiology and poor prognosis, and currently lacks specific and effective treatment options. Mitochondrial dynamics dysfunction is a prominent feature in AKI, and modulation of mitochondrial morphology may serve as a potential therapeutic approach for AKI. METHODS: We induced ischemia-reperfusion injury (IRI) in mice (bilateral) and Bama pigs (unilateral) by occluding the renal arteries...
March 4, 2024: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/38430666/clinical-importance-of-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and-systemic-immune-inflammation-index-in-dogs-with-leishmaniasis
#13
JOURNAL ARTICLE
A Durán-Galea, J I Cristóbal-Verdejo, R Barrera-Chacón, B Macías-García, M A González-Solís, P Nicolás-Barceló, A B García-Ibáñez, P Ruíz-Tapia, F J Duque-Carrasco
Leishmaniasis is a zoonotic disease caused by Leishmania spp., impacts multiple systems and organs. While hematological and biochemical profiles aren't definitive for diagnosis, recent studies have identified the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) as predictors of morbidity and mortality in critically ill human and dog patients. This study examined 100 dogs diagnosed with leishmaniasis, categorized by the International Renal Interest Society (IRIS) stages 1-4...
February 23, 2024: Comparative Immunology, Microbiology and Infectious Diseases
https://read.qxmd.com/read/38428147/characterization-of-macrophages-in-ischemia-reperfusion-injury-induced-acute-kidney-injury-based-on-single-cell-rna-seq-and-bulk-rna-seq-analysis
#14
JOURNAL ARTICLE
Qin Wang, Yuxing Liu, Yan Zhang, Siyuan Zhang, Meifang Zhao, Zhangzhe Peng, Hui Xu, Hao Huang
Acute kidney injury (AKI) is a complex disease, with macrophages playing a vital role in its progression. However, the mechanism of macrophage function remains unclear and strategies targeting macrophages in AKI are controversial. To address this issue, we used single-cell RNA-seq analysis to identify macrophage sub-types involved in ischemia-reperfusion-induced AKI, and then screened for associated hub genes using intersecting bulk RNA-seq data. The single-cell and bulk RNA-seq datasets were obtained from the Gene Expression Omnibus (GEO) database...
February 29, 2024: International Immunopharmacology
https://read.qxmd.com/read/38396887/evaluating-the-effects-of-kidney-preservation-at-10-%C3%A2-c-with-hemopure-and-sodium-thiosulfate-in-a-rat-model-of-syngeneic-orthotopic-kidney-transplantation
#15
JOURNAL ARTICLE
Maria Abou Taka, George J Dugbartey, Mahms Richard-Mohamed, Patrick McLeod, Jifu Jiang, Sally Major, Jacqueline Arp, Caroline O'Neil, Winnie Liu, Manal Gabril, Madeleine Moussa, Patrick Luke, Alp Sener
Kidney transplantation is preferred for end-stage renal disease. The current gold standard for kidney preservation is static cold storage (SCS) at 4 °C. However, SCS contributes to renal graft damage through ischemia-reperfusion injury (IRI). We previously reported renal graft protection after SCS with a hydrogen sulfide donor, sodium thiosulfate (STS), at 4 °C. Therefore, this study aims to investigate whether SCS at 10 °C with STS and Hemopure (blood substitute), will provide similar protection...
February 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38395179/network-pharmacology-and-experimental-validation-to-investigate-the-mechanism-of-nao-ling-su-capsule-in-the-treatment-of-ischemia-reperfusion-induced-acute-kidney-injury
#16
JOURNAL ARTICLE
Yongqiang Lin, Lili Xu, Huibin Lin, Weiliang Cui, Yang Jiao, Bing Wang, Huifen Li, Xiaojie Wang, Jichao Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Nao-Ling-Su Capsule (NLSC) is a traditional prescription, which is composed of fifteen herbs such as epimedium, Polygala tenuifolia, and Schisandra chinensis. It has the effect of strengthening the brain, calming nerves, and protecting the kidney, which has been used clinically for many years to strengthen the brain and kidney. However, the effect of NLSC in the treatment of acute kidney injury (AKI) is still unclear. AIM OF THE STUDY: The present study aims to elucidate the pharmacological actions of NLSC in the treatment of AKI...
February 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38388468/chop-mediated-gasdermin-e-expression-promotes-pyroptosis-inflammation-and-mitochondrial-damage-in-renal-ischemia-reperfusion-injury
#17
JOURNAL ARTICLE
Nannan Ma, Hao Lu, Ning Li, Weijian Ni, Wenbo Zhang, Qiang Liu, Wenzheng Wu, Shichao Xia, Jiagen Wen, Tao Zhang
In clinical practice, renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI), often leading to acute renal failure or end-stage renal disease (ESRD). The current understanding of renal IRI mechanisms remains unclear, and effective therapeutic strategies and clear targets are lacking. Therefore, the need to find explicit and effective ways to reduce renal IRI remains a scientific challenge. The current study explored pyroptosis, a type of inflammation-regulated programmed cell death, and the role of Gasdermins E (GSDME)-mediated pyroptosis, mitochondrial damage, and inflammation in renal IRI...
February 22, 2024: Cell Death & Disease
https://read.qxmd.com/read/38372356/bilateral-renal-ischemia-reperfusion-model-for-acute-kidney-injury-in-mice
#18
JOURNAL ARTICLE
Junni Wang, Huanhuan Zhu, Jin Miao, Weiqiang Lin, Fei Han
Acute kidney injury (AKI) is defined as a rapid decline in renal function, in which persistent kidney dysfunction gradually progresses to chronic kidney disease (CKD) due to the irreversible loss of nephrons and their maladaptive repair. In recent years, the incidence of AKI has been increasing concerning diverse etiologies, including volume depletion, sepsis, nephrotoxicity, muscle injury, and major trauma, in which ischemia-reperfusion injury (IRI) accounts for most episodes. Development of the IRI model in mice is induced by surgical clamping of the renal pedicles, which provides powerful and controllable tools for preclinical models of AKI...
February 2, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38370256/protective-effect-of-tetrandrine-on-optic-nerve-by-inhibiting-glial-activation-through-nf-%C3%AE%C2%BAb-pathway
#19
JOURNAL ARTICLE
Weiyi Li, Jing Cao, Jian Liu, Shuiling Chen, Min Dai, Mingming Zhang, Xinyue Hou, Jianquan Wang, Zefeng Kang
INTRODUCTION: This study aimed to explore the effect and molecular mechanism of Tetrandrine (Tet) onlipopolysaccharide (LPS)-induceduveitis andoptic nerve injury in vivo and in vitro . METHODS: Uveitis was induced by LPS injected into the hindlimb foot pad of Wistar rats and was intervened by retroeyeball injection of Tet (100 nM, 1 μM or 10 μM).The anterior segment inflammation was observed by slit lamp. Tunelassay was used to detect the survival state of ganglion cells and nuclear layers of inner and outer...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38368866/multi-omics-integrated-analysis-of-the-protective-effect-of-ezh2-inhibition-in-mice-with-renal-ischemia-reperfusion-injury
#20
JOURNAL ARTICLE
Shanshan Zou, Jianing Chen, Peihui Zhou, Mengzhu Xue, Ming Wu, Li Wang
INTRODUCTION: Acute kidney injury (AKI) is a common clinical syndrome associated with high morbidity and mortality. Inhibition of the methyltransferase Enhancer of Zeste Homolog 2 (EZH2) by its inhibitor 3-DZNeP (3-Deazaneplanocin A) exerts renal benefits in acute renal ischemia-reperfusion injury (IRI). However, the underlying mechanisms is not completely known. This study aimed to elucidate the pathological mechanism of EZH2 in renal IRI by combination of multi-omics analysis and expression profiling in a public clinical cohort...
February 18, 2024: Kidney & Blood Pressure Research
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