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renal IRI

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https://www.readbyqxmd.com/read/29904208/feline-hepatobiliary-neoplasia-and-mistaken-age
#1
Kathryn M Hotke
A cat, thought to be 5 years old, and with reduced appetite and weight loss, was presented for dental cleaning and extractions. Bile duct origin hepatic carcinoma was diagnosed. The progression of iris degeneration, dental disease, histological renal lesions, spondylosis, and hepatobiliary neoplasia suggest this cat was closer to 10 years old.
May 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29897289/the-impact-of-cannabidiol-treatment-on-regulatory-t-17-cells-and-neutrophil-polarization-in-acute-kidney-injury
#2
Babak Baban, Md Nasrul Hoda, Aneeq Malik, Hesam Khodadadi, Erika Simmerman, Kumar Vaibhav, Mahmood S Mozaffari
Hallmark features of acute kidney injury (AKI) include mobilization of immune and inflammatory mechanisms culminating in tissue injury. Emerging information indicates heterogeneity of neutrophils with pro- and anti-inflammatory functions (N1 and N2, respectively). Also, regulatory T-17 (Treg17) cells curtail Th-17-mediated pro-inflammatory responses. However, the status of Treg17 cells and neutrophil phenotypes in AKI are not established. Further, cannabidiol exerts immunoregulatory effects but its impact on Treg17 cells and neutrophil subtypes is not established...
June 13, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29895432/targeted-inhibition-of-axl-receptor-tyrosine-kinase-ameliorates-anti-gbm-induced-lupus-like-nephritis
#3
Yuxuan Zhen, Iris J Lee, Fred D Finkelman, Wen-Hai Shao
Glomerulonephritis (GN) is a typical lesion in autoantibody and immune complex disorders, including SLE. Because the Gas6/Axl pathway has been implicated in the pathogenesis of many types of GN, targeting this pathway might ameliorate GN. Consequently, we have studied the efficacy and mechanism of R428, a potent selective Axl inhibitor, in the prevention of experimental anti-GBM nephritis. Axl upregulation was investigated with Sp1/3 siRNA in the SV40-transformed mesangial cells. For Axl inhibition, a daily dose of R428 (125 mg/kg) or vehicle was administered orally...
June 9, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29880359/impact-of-volatile-anesthetic-agents-on-early-clinical-outcomes-in-liver-transplantation
#4
R S Mangus, S B Kinsella, D T Farar, J A Fridell, L T Woolf, C A Kubal
BACKGROUND: Few studies have assessed the ability of inhaled anesthetic agents to ameliorate ischemia-reperfusion injury (IRI) in liver transplantation (LT). This study compares inhaled anesthetics in early liver allograft IRI. LT recipient and organ donor data were extracted retrospectively for all LTs at a single center between 2001 and 2015. METHODS: LT recipient and organ donor data were extracted retrospectively for all LTs at a single center between 2001 and 2015...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29878499/the-future-of-marginal-kidney-repair-in-the-context-of-normothermic-machine-perfusion
#5
Jenna R DiRito, Sarah A Hosgood, Gregory T Tietjen, Michael L Nicholson
Normothermic machine perfusion (NMP) is a technique that utilizes extra-corporeal membrane oxygenation to recondition and repair kidneys at near body temperature prior to transplantation. The application of this new technology has been fuelled by a significant increase in the use of the kidneys donated after circulatory death (DCD), which are more susceptible to ischaemic injury. Preliminary results indicate that normothermic machine perfusion itself may be able to repair marginal organs prior to transplantation...
June 7, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29845768/persistent-expression-of-neutrophil-gelatinase-associated-lipocalin-and-m2-macrophage-markers-and-chronic-fibrosis-after-acute-kidney-injury
#6
Hisako Saito, Tetsuhiro Tanaka, Shinji Tanaka, Yoshiki Higashijima, Junna Yamaguchi, Mai Sugahara, Marie Ito, Lisa Uchida, Sho Hasegawa, Takeshi Wakashima, Kenji Fukui, Masaomi Nangaku
Recent epidemiologic studies revealed a correlation between acute kidney injury (AKI) episodes and the progression to chronic kidney disease (CKD). Although the severity and duration of the initial insult likely predict the development of CKD, information regarding tissue markers predictive of early development of renal fibrosis is limited. We investigated key markers in fibrotic kidney in rats and mice. Seven- to eight-week-old male Sprague-Dawley rats underwent bilateral ischemia-reperfusion injury (IRI)...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29791205/physiologic-hyperinsulinemia-caused-by-acute-hyperglycemia-minimizes-renal-sodium-loss-by-direct-action-on-the-kidney
#7
Debra L Irsik, Michael W Brands
This study used acute, renal-artery insulin infusion in conscious rats to test the hypothesis that hyperinsulinemia attenuates glucose-induced natriuresis by a direct renal mechanism. We reported previously that hyperinsulinemia was required to prevent ad libitum eating or an acute glucose bolus from causing excessive renal sodium loss. Rats were instrumented with renal artery, aortic, and femoral vein catheters and DSI blood pressure telemeters and were housed in metabolic cages. Insulin was clamped chronically at normal levels in two groups (irV and irI) by administering streptozotocin and then infusing insulin iv...
May 23, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29775204/effects-of-%C3%AE-tocotrienol-on-ochratoxin-a-induced-nephrotoxicity-in-rats
#8
Sara Damiano, Luigi Navas, Patrizia Lombari, Serena Montagnaro, Iris M Forte, Antonio Giordano, Salvatore Florio, Roberto Ciarcia
Ochratoxin A (OTA), is a natural contaminant of the food chain worldwide involved in the development of different type of cancers in animals and humans. Several studies suggested that oxidative damage might contribute to increase the cytotoxicity and carcinogenicity capabilities of OTA. The aim of this study was to evaluate the possible protective effect of δ-tocotrienol (Delta), a natural form of vitamin E, against OTA-induced nephrotoxicity. Male Sprague-Dawley rats were treated with OTA and/or Delta by gavage for 14 days...
May 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29773759/neutrophil-lymphocyte-ratio-and-creatinine-reduction-ratio-predict-good-early-graft-function-among-adult-cadaveric-donor-renal-transplant-recipients-single-institution-series
#9
Piotr Hogendorf, Anna Suska, Aleksander Skulimowski, Joanna Rut, Monika Grochowska, Aleksandra Wencel, Filip Dziwisz, Michał Nowicki, Dariusz Szymański, Grażyna Poznańska, Adam Durczyński, Janusz Strzelczyk
Background Delayed graft function (DGF) is a common complication following kidney transplantation and is associated with ischemia-reperfusion injury (IRI). Lymphocytes contribute to the pathogenesis of IRI and ischemia-reperfusion related delayed graft function Materials and Methods 135 Caucasian patients received a kidney graft from deceased heart-beating organ donors. We divided patients into 2 groups- patients with the eGFR>=30 on the 21st day post-transplantation (n=36) and patients with the eGFR<30 on the 21st day post-transplantation (n=99) to assess kidney graft function...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29762865/population-pharmacokinetics-of-vancomycin-in-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#10
Akira Okada, Misato Kariya, Kei Irie, Yutaka Okada, Nobuhiro Hiramoto, Hisako Hashimoto, Ryosuke Kajioka, Chika Maruyama, Hidefumi Kasai, Mami Hamori, Asako Nishimura, Nobuhito Shibata, Keizo Fukushima, Nobuyuki Sugioka
Vancomycin is a commonly used antimicrobial agent for patients undergoing allogeneic hematopoietic stem-cell transplantation (allo-HSCT). Vancomycin has large inter- and intraindividual pharmacokinetic variability, which is mainly described by renal function; various studies have indicated that vancomycin pharmacokinetics are altered in special populations. However, little is known regarding vancomycin pharmacokinetics in patients undergoing allo-HSCT. Therefore, we aimed to develop a population pharmacokinetic (PopPK) model of vancomycin in patients undergoing allo-HSCT for effective and safe antimicrobial therapy and to develop a vancomycin dosing nomogram for a vancomycin optimal-dosing strategy...
May 15, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29754505/1-formula-see-text-2-formula-see-text-3-formula-see-text-4-formula-see-text-6-penta-o-galloyl-%C3%AE-d-glucose-from-galla-rhois-ameliorates-renal-tubular-injury-and-microvascular-inflammation-in-acute-kidney-injury-rats
#11
Ji Hun Park, Min Chol Kho, Hyun Cheol Oh, Youn Chul Kim, Jung Joo Yoon, Yun Jung Lee, Dae Gill Kang, Ho Sub Lee
Renal ischemia-reperfusion injury (IRI), an important cause of acute kidney injury (AKI), causes increased renal tubular injury and microvascular inflammation. 1,[Formula: see text]2,[Formula: see text]3,[Formula: see text]4,[Formula: see text]6-penta-O-galloyl-[Formula: see text]-D-glucose (PGG) from Galla rhois has anticancer, anti-oxidation and angiogenesis effects. We examined protective effects of PGG on IRI-induced acute AKI. Clamping both renal arteries for 45[Formula: see text]min induced isechemia and then reperfusion...
May 13, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29737200/human-peripheral-blood-mononuclear-cells-incubated-in-vasculogenic-conditioning-medium-dramatically-improve-ischemia-reperfusion-acute-kidney-injury-in-mice
#12
Takayasu Ohtake, Shuzo Kobayashi, Shimon Slavin, Yasuhiro Mochida, Kunihiro Ishioka, Hidekazu Moriya, Sumi Hidaka, Ryo Matsuura, Maki Sumida, Daisuke Katagiri, Eisei Noiri, Kayoko Okada, Hiroshi Mizuno, Rica Tanaka
Acute kidney injury (AKI) is a major clinical problem that still has no established treatment. We investigated the efficacy of cultured human peripheral blood mononuclear cells (PBMNCs) for AKI. Ischemia/reperfusion injury (IRI) was used to induce AKI in male nonobese diabetic (NOD/severe combined immunodeficiency) mice aged 7 to 8 wk. PBMNCs were isolated from healthy volunteers and were subjected to quality and quantity controlled (QQc) culture for 7 d in medium containing stem cell factor, thrombopoietin, Flt-3 ligand, vascular endothelial growth factor, and interleukin 6...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29734167/protective-effect-of-nicotinamide-adenine-dinucleotide-phosphate-on-renal-ischemia-reperfusion-injury
#13
Xiao-Fen Weng, Song-Tao Li, Qi Song, Qi Zhu, Dan-Dan Song, Zheng-Hong Qin, Yan Xie
BACKGROUND/AIMS: Renal ischemia-reperfusion injury (IRI) is a common consequence of acute kidney injury. Nicotinamide adenine dinucleotide phosphate (NADPH), which is derived from the pentose phosphate pathway, is essential for the proper functioning of essential redox and antioxidant defense systems. Previous studies have indicated that NADPH is responsible for protecting the brain from ischemic injury. The goal of this study was to analyze the protective function of NADPH in renal IRI...
May 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29733848/polyacetylene-glycoside-attenuates-ischemic-kidney-injury-by-co-inhibiting-inflammation-mitochondria-dysfunction-and-lipotoxicity
#14
Yijie Zhou, Dan Du, Shuyun Liu, Meng Zhao, Yujia Yuan, Lan Li, Younan Chen, Yanrong Lu, Jingqiu Cheng, Jingping Liu
AIMS: Ischemic acute kidney injury (AKI) is a serious clinical problem and no efficient therapeutics is available in clinic now. Natural polyacetylene glycosides (PGAs) had shown antioxidant and anti-inflammatory properties, but their effects on kidney injury have not been evaluated. This study aimed to investigate the protective effect of PGA on ischemic kidney injury in renal tubular epithelial cells (TECs) and mice. MAIN METHODS: Hypoxic HK-2 cells and renal ischemia/reperfusion injury (IRI) mice were treated with PGA from Coreopsis tinctoria, and the cell viability, renal function, apoptosis, inflammation, mitochondrial injury, lipids metabolism were analyzed...
May 4, 2018: Life Sciences
https://www.readbyqxmd.com/read/29731086/crepidiastrum-denticulatum-extract-ameliorates-kidney-ischemia-reperfusion-injury-in-mice
#15
J S Kim, H J Jang, E K Jeong, S S Kim, Y M Kim, J H Lee, M Y Oh, D K Lee, K Yelithao, H C Kwan, C W Nho, D W Eom
BACKGROUND: Crepidiastrum denticulatum (CD) is a well-known, traditionally consumed vegetable in Korea, which was recently reported to contain bioactive compounds with detoxification and antioxidant properties. Ischemia-reperfusion injury (IRI) is a major problem after renal transplantation. Furthermore, inflammatory responses to IRI exacerbate the resultant renal injury. In the present study, we investigated whether CD extract exhibits renoprotective effects against IR-induced acute kidney injury in mice...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29713320/a-conformational-change-in-c-reactive-protein-enhances-leukocyte-recruitment-and-reactive-oxygen-species-generation-in-ischemia-reperfusion-injury
#16
Jan R Thiele, Johannes Zeller, Jurij Kiefer, David Braig, Sheena Kreuzaler, Yvonne Lenz, Lawrence A Potempa, Florian Grahammer, Tobias B Huber, M Huber-Lang, Holger Bannasch, G Björn Stark, Karlheinz Peter, Steffen U Eisenhardt
Introduction: C-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation. We recently described pro-inflammatory properties of CRP, which are mediated by conformational changes from pCRP to bioactive isoforms expressing pro-inflammatory neo-epitopes [pCRP* and monomeric C-reactive protein (mCRP)]. Here, we investigate the role of CRP isoforms in renal ischemia/reperfusion injury (IRI)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29704468/renal-ischemia-reperfusion-induced-mitophagy-protects-against-renal-dysfunction-via-drp1-dependent-pathway
#17
Nan Li, Hengjin Wang, Chunming Jiang, Miao Zhang
Autophagy is upregulated under stress conditions to degrade superfluous proteins and recycle damaged organelles including damaged mitochondria. However, the occurrence of mitochondrial autophagy and its contribution remain to be elucidated during renal ischemia/reperfusion injury (IRI). In this study, mitophagosomes and engulfed mitochondria were frequently observed by electron microscopy after renal IRI vs. control. Meanwhile, the increase of lipidated microtubule associated protein light chain 3 (LC3-II) and decrease of mitochondrial proteins were detected by western blot, suggesting the presence of mitophagy...
August 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29704284/prognostic-importance-of-plasma-total-magnesium-in-a-cohort-of-cats-with-azotemic-chronic-kidney-disease
#18
D Hendrik N van den Broek, Yu-Mei Chang, Jonathan Elliott, Rosanne E Jepson
BACKGROUND: Hypomagnesemia is associated with increased mortality and renal function decline in humans with chronic kidney disease (CKD). Magnesium is furthermore inversely associated with fibroblast growth factor 23 (FGF23), an important prognostic factor in CKD in cats. However, the prognostic significance of plasma magnesium in cats with CKD is unknown. OBJECTIVES: To explore associations of plasma total magnesium concentration (tMg) with plasma FGF23 concentration, all-cause mortality, and disease progression in cats with azotemic CKD...
April 27, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29699633/mir-17-92-ameliorates-renal-ischemia-reperfusion-injury
#19
Turun Song, Mianzhi Chen, Zhengsheng Rao, Yang Qiu, Jinpeng Liu, Yamei Jiang, Zhongli Huang, Xianding Wang, Tao Lin
There is limited information on the role of miR-17-92 in renal tubular pathophysiology. Therefore, the present study was performed to determine whether miR-17-92 plays a role in ischemia-reperfusion injury (IRI)-induced acute kidney injury. We originally demonstrated that miR-17-92 is up-regulated following IRI in vivo. To explore the roles of miR-17-92 in the IRI process, we first generated a renal proximal tubule-specific miR-17-92 deletion (PT-miR-17-92-/- ) knockout mouse model with Cre driven by the Kap promoter...
May 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29695055/efficacy-of-a-moderately-low-carbohydrate-diet-in-a-36-month-observational-study-of-japanese-patients-with-type-2-diabetes
#20
Mariko Sanada, Chinatsu Kabe, Hisa Hata, Junichi Uchida, Gaku Inoue, Yoko Tsukamoto, Yoshifumi Yamada, Junichiro Irie, Shogo Tabata, Mitsuhisa Tabata, Satoru Yamada
We previously showed that a non-calorie-restricted, moderately low-carbohydrate diet (mLCD) is more effective than caloric restriction for glycemic and lipid profile control in patients with type 2 diabetes. To determine whether mLCD intervention is sustainable, effective, and safe over a long period, we performed a 36-month observational study. We sequentially enrolled 200 patients with type 2 diabetes and taught them how to follow the mLCD. We compared the following parameters pre- and post-dietary intervention in an outpatient setting: glycated hemoglobin (HbA1c), body weight, lipid profile (total cholesterol, low and high-density lipoprotein cholesterol, triglycerides), systolic and diastolic blood pressure, liver enzymes (aspartate aminotransferase, alanine aminotransferase), and renal function (urea nitrogen, creatinine, estimated glomerular filtration rate)...
April 24, 2018: Nutrients
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