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renal IRI

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https://www.readbyqxmd.com/read/29451033/control-release-of-mitochondria-targeted-antioxidant-by-injectable-self-assembling-peptide-hydrogel-ameliorated-persistent-mitochondrial-dysfunction-and-inflammation-after-acute-kidney-injury
#1
Meng Zhao, Yijie Zhou, Shuyun Liu, Lan Li, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Persistent mitochondrial injury occurs after acute kidney injury (AKI) and mitochondria-targeted antioxidant Mito-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) (MT) has shown benefits for AKI, but its efficiency is limited by short half-life and side effect in vivo. Self-assembling peptide (SAP) hydrogel is a robust platform for drug delivery. This study aims to develop an SAP-based carrier to slow release MT for enhancing its long-term therapeutic potency on AKI. The KLD with aspartic acid (KLDD) was designed...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29446739/role-of-complement-properdin-in-renal-ischemia-reperfusion-injury
#2
Zinah Zwaini, Houyong Dai, Cordula Stover, Bin Yang
Renal ischemia-reperfusion injury (IRI) is one of the main causes of acute kidney injury (AKI), and may lead to chronic kidney disease. The high mortality rate of AKI has not changed in the last 5 decades due to non-recognition, nephrotoxin exposure, delayed diagnosis and lack of specific intervention. Complement activation plays important roles in IRI-induced AKI because of its association with immunity, inflammation, cell death and tissue repair. Nevertheless, the role of complement properdin, the sole positive regulator of the alternative pathway, in IRI-induced AKI has not been well defined...
February 13, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29446737/gene-modified-mesenchymal-stem-cell-based-therapy-in-renal-ischemia-reperfusion-injury
#3
Hongbo Xu, Cheng Chen, Linkun Hu, Jianquan Hou
Acute kidney injury (AKI) is a common syndrome in the clinic and has become a worldwide public health problem. Renal ischemia-reperfusion injury (IRI) is the most common cause of AKI. So far, effective treatment is still lacking for renal IRI, resulting in a high mortality rate of AKI. Mesenchymal stem cells (MSCs), considered as a promising candidate for tissue repair and regenerative medicine have aroused an increasing concern in recent years for the capacity of self-renewal and multi-lineage differentiation...
February 13, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29441948/regulation-and-mechanism-of-mir-146-on-renal-ischemia-reperfusion-injury
#4
Yuyu Huang, Hongwu Wang, Yanhui Wang, Xiaohui Peng, Jing Li, Wenlong Gu, Ting He, Minjun Chen
AIM: MicroRNAs (miRs) are endogenous substances that act as important diagnostic and treatment targets in renal diseases. miR-146 plays an important role in the development of endotoxin tolerance through NF-κB pathway, but the underlying mechanism is not clearly understood. The aim of this study was to determine the molecular regulation and function of miR-146 and also the expression of miR-146 in an experimental model of renal ischemia reperfusion injury (IRI). METHODS: IRI was induced in mouse by bilateral IRI for 45 min followed by reperfusion...
January 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29428089/plasma-indoxyl-sulfate-concentration-predicts-progression-of-chronic-kidney-disease-in-dogs-and-cats
#5
C N Chen, C C Chou, P S J Tsai, Y J Lee
Indoxyl sulfate is a protein-bound uremic toxin that increases as the severity of impaired renal function increases in humans, laboratory animals, dogs and cats. An elevation of indoxyl sulfate is related to prognosis among people with chronic kidney disease. However, whether indoxyl sulfate is able to predict the progression of chronic kidney disease in dogs and cats has not been previously studied. In the present study, 58 cats and 36 dogs with chronic kidney disease were enrolled. Plasma indoxyl sulfate was measured by high performance liquid chromatography...
February 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29425283/development-of-a-dosing-nomogram-for-continuous-infusion-meropenem-in-critically-ill-patients-based-on-a-validated-population-pharmacokinetic-model
#6
Iris K Minichmayr, Jason A Roberts, Otto R Frey, Anka C Roehr, Charlotte Kloft, Alexander Brinkmann
Background: Optimal antibiotic exposure is a vital but challenging prerequisite for achieving clinical success in ICU patients. Objectives: To develop and externally validate a population pharmacokinetic model for continuous-infusion meropenem in critically ill patients and to establish a nomogram based on a routinely available marker of renal function. Methods: A population pharmacokinetic model was developed in NONMEM® 7.3 based on steady-state meropenem concentrations (CSS) collected during therapeutic drug monitoring...
February 7, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29420536/randomized-trial-of-one-hour-sodium-bicarbonate-vs-standard-periprocedural-saline-hydration-in-chronic-kidney-disease-patients-undergoing-cardiovascular-contrast-procedures
#7
Judith Kooiman, Jean-Paul P M de Vries, Jan Van der Heyden, Yvo W J Sijpkens, Paul R M van Dijkman, Jan J Wever, Hans van Overhagen, Antonie C Vahl, Nico Aarts, Iris J A M Verberk-Jonkers, Harald F H Brulez, Jaap F Hamming, Aart J van der Molen, Suzanne C Cannegieter, Hein Putter, Wilbert B van den Hout, Inci Kilicsoy, Ton J Rabelink, Menno V Huisman
BACKGROUND: Guidelines advise periprocedural saline hydration for prevention of contrast induced-acute kidney injury (CI-AKI). We analysed whether 1-hour sodium bicarbonate hydration administered solely prior to intra-arterial contrast exposure is non-inferior to standard periprocedural saline hydration in chronic kidney disease (CKD) patients undergoing elective cardiovascular diagnostic or interventional contrast procedures. METHODS: We performed an open-label multicentre non-inferiority trial between 2011-2014...
2018: PloS One
https://www.readbyqxmd.com/read/29412002/close-pathological-correlations-between-chronic-kidney-disease-and-reproductive-organ-associated-abnormalities-in-female-cotton-rats
#8
Osamu Ichii, Teppei Nakamura, Takao Irie, Hirokazu Kouguchi, Kozue Sotozaki, Taro Horino, Yuji Sunden, Yaser Hosny Ali Elewa, Yasuhiro Kon
Cotton rat ( Sigmodon hispidus) is a useful experimental rodent for the study of human infectious diseases. We previously clarified that cotton rats, particularly females, developed chronic kidney disease characterized by cystic lesions, inflammation, and fibrosis. The present study investigated female-associated factors for chronic kidney disease development in cotton rats. Notably, female cotton rats developed separation of the pelvic symphysis and hypertrophy in the vaginal parts of the cervix with age, which strongly associated with pyometra...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29403551/pterostilbene-protects-against-acute-renal-ischemia-reperfusion-injury-and-inhibits-oxidative-stress-inducible-nitric-oxide-synthase-expression-and-inflammation-in-rats-via-the-toll-like-receptor-4-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway
#9
Dan Gao, Sanhui Jing, Qian Zhang, Ge Wu
Previous studies have demonstrated that pterostilbene (Pter) prevents oxidative stress, suppresses cell growth and exhibits anti-fungal and anti-inflammatory effects. Pter is used to treat a number of clinical diseases, including Alzheimer's disease, various malignancies and hypercholesteremia. The aim of the present study was to investigate whether Pter protects against acute renal ischemia reperfusion injury (IRI) and inhibits oxidative stress, inducible nitric oxide synthase (iNOS) expression and inflammation in rats...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29398595/ischemia-reperfusion-injury-reduces-long-term-renal-graft-survival-mechanism-and-beyond
#10
REVIEW
Hailin Zhao, Azeem Alam, Aurelie Pac Soo, Andrew J T George, Daqing Ma
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific inflammatory responses that can result in the loss of kidney graft viability. However, the long-term consequence of IRI on renal grafts survival is uncertain. Here we review clinical evidence and laboratory studies, and elucidate the association between early IRI and later graft loss. Our critical analysis of previous publications indicates that early IRI does contribute to later graft loss through reduction of renal functional mass, graft vascular injury, and chronic hypoxia, as well as subsequent fibrosis...
February 1, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29384471/a-novel-approach-to-off-clamp-partial-nephrectomy-demonstrates-significant-improvements-in-renal-injury-in-an-experimental-porcine-model
#11
Daniel Olvera-Posada, Shouzhe Lin, Ghaleb Aboalsamh, Aaron Haig, Ian Lobb, Jaskirandeep Grewal, Manujendra N Saha, Alp Sener
INTRODUCTION: We sought to design a partial nephrectomy (PN) with contralateral total nephrectomy porcine model and assess the underlying mechanisms of ischemia reperfusion injury (IRI) after PN using a novel, clinically approved resection device. METHODS: Domestic male pigs (n=9) underwent left lower pole PN, allocated to either standard (Group 1) or no ischemia PN (Group 2), followed by contralateral nephrectomy. Biochemical studies were performed at baseline, Day 2, and Day 7; after sacrifice, kidneys were processed for histological analysis...
October 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29382757/rgmb-protects-against-acute-kidney-injury-by-inhibiting-tubular-cell-necroptosis-via-an-mlkl-dependent-mechanism
#12
Wenjing Liu, Binbin Chen, Yang Wang, Chenling Meng, Huihui Huang, Xiao-Ru Huang, Jinzhong Qin, Shrikant R Mulay, Hans-Joachim Anders, Andong Qiu, Baoxue Yang, Gordon J Freeman, Hua Jenny Lu, Herbert Y Lin, Zhi-Hua Zheng, Hui-Yao Lan, Yu Huang, Yin Xia
Tubular cell necrosis is a key histological feature of acute kidney injury (AKI). Necroptosis is a type of programed necrosis, which is executed by mixed lineage kinase domain-like protein (MLKL) upon its binding to the plasma membrane. Emerging evidence indicates that necroptosis plays a critical role in the development of AKI. However, it is unclear whether renal tubular cells undergo necroptosis in vivo and how the necroptotic pathway is regulated during AKI. Repulsive guidance molecule (RGM)-b is a member of the RGM family...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29357437/renal-ischemia-reperfusion-injury-causes-hypertension-and-renal-perfusion-impairment-in-the-cd1-mice-which-promotes-progressive-renal-fibrosis
#13
Robert Greite, Anja Thorenz, Rongjun Chen, Mi-Sun Jang, Song Rong, Michael J Brownstein, Susanne Tewes, Li Wang, Bita Baniassad, Torsten Kirsch, Jan Hinrich Bräsen, Ralf Lichtinghagen, Martin Meier, Hermann Haller, Katja Hueper, Faikah Gueler
Renal ischemia reperfusion injury (IRI) is a severe complication after major surgery and a risk factor for increased morbidity and mortality. We investigated potential mechanisms, which contribute to IRI induced progression to chronic kidney disease. Acute kidney injury was induced by unilateral IRI for 35 min in CD1 and C57BL/6 (B6) mice. Unilateral IRI was chosen in order to overcome mortality. Renal morphology, NGAL up-regulation, and neutrophil infiltration as well as peritubular capillary density was studied by immunohistochemistry...
December 20, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29349383/endovascular-extraction-of-a-migrated-large-self-expanding-laser-cut-renal-venous-stent-from-the-right-ventricle
#14
Tim Sebastian, Gabor Erdoes, Vlad A Bratu, Iris Baumgartner, Nils Kucher
Endovascular stent placement for decompression of an entrapped left renal vein (LRV) between the aorta and superior mesenteric artery is an alternative to surgical decompression for treating the nutcracker syndrome. However, an interventional approach may be challenging because of the unfavorable configuration of the LRV, leading to insufficient stent anchoring. We provide a case of a life-threatening stent migration from the LRV into the right ventricle 2 days after stent placement and its endovascular retrieval...
June 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29343518/fibroblast-specific-%C3%AE-catenin-signaling-dictates-the-outcome-of-aki
#15
Dong Zhou, Haiyan Fu, Liangxiang Xiao, Hongyan Mo, Hui Zhuo, Xiaojun Tian, Lin Lin, Jianhua Xing, Youhua Liu
AKI is a devastating condition with high morbidity and mortality. The pathologic features of AKI are characterized by tubular injury, inflammation, and vascular impairment. Whether fibroblasts in the renal interstitium have a role in the pathogenesis of AKI is unknown. In this study, we investigated the role of fibroblast-specific β -catenin signaling in dictating the outcome of AKI, using conditional knockout mice in which β -catenin was specifically ablated in fibroblasts (Gli1- β -cat-/-). After ischemia-reperfusion injury (IRI), Gli1- β -cat-/- mice had lower serum creatinine levels and less morphologic injury than Gli1- β -cat+/+ littermate controls...
January 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29324683/pentoxifylline-and-methylprednisolone-additively-alleviate-kidney-failure-and-prolong-survival-of-rats-after-renal-warm-ischemia-reperfusion
#16
Grzegorz Wystrychowski, Wojciech Wystrychowski, Władysław Grzeszczak, Andrzej Więcek, Robert Król, Antoni Wystrychowski
Renal ischemia-reperfusion injury (IRI) induces local inflammation leading to kidney damage. Since pentoxifylline (PTX) and steroids have distinct immunomodulatory properties, we aimed to evaluate for the first time their combined use in IRI-induced acute kidney injury (AKI) and chronic kidney disease (CKD) in rats. In two experiments, PTX (100 mg/kg body weight subcutaneously) was administered 90 min prior to renal IRI or/and methylprednisolone (MP; 100 mg/kg body weight intramuscularly) was infused 60 min after reperfusion of a solitary kidney (AKI model: 45 min ischemia, 48 male Sprague-Dawley rats) or one kidney with excision of contralateral kidney 2 weeks later (CKD model: 90 min ischemia, 38 rats)...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29311521/relationship-between-indirect-blood-pressure-and-various-stages-of-chronic-kidney-disease-in-cats
#17
Yasutomo Hori, Yasuhiro Heishima, Yohei Yamashita, Noriko Isayama, Nobuyuki Kanno, Kensuke Nakamura, Masayuki Iguchi, Toshiki Ibaragi, Hideyuki Onodera, Yoshitaka Aramaki, Atsushi Hirakawa, Shigeki Yamano, Michio Katagi, Akihito Kitade, Tamotsu Sawada
Chronic kidney disease (CKD) is a common cause of secondary systemic hypertension in cats. We investigated the relationship between indirect blood pressure and the prevalence of systemic hypertension in various CKD stages in cats. Client-owned cats (24 control cats and 77 cats with CKD) were included. Biochemical examinations of plasma were conducted by a commercial laboratory. Diseased cats were divided into two groups based on the International Renal Interest Society (IRIS) guidelines (II and III-IV). Indirect blood pressure was measured using an oscillometric technique...
January 3, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29307833/analysis-of-spatiotemporal-metabolomic-dynamics-for-sensitively-monitoring-biological-alterations-in-cisplatin-induced-acute-kidney-injury
#18
Miho Irie, Eisuke Hayakawa, Yoshinori Fujimura, Youhei Honda, Daiki Setoyama, Hiroyuki Wariishi, Fuminori Hyodo, Daisuke Miura
Clinical application of the major anticancer drug, cisplatin, is limited by severe side effects, especially acute kidney injury (AKI) caused by nephrotoxicity. The detailed metabolic mechanism is still largely unknown. Here, we used an integrated technique combining mass spectrometry imaging (MSI) and liquid chromatography-mass spectrometry (LC-MS) to visualize the diverse spatiotemporal metabolic dynamics in the mouse kidney after cisplatin dosing. Biological responses to cisplatin was more sensitively detected within 24 h as a metabolic alteration, which is much earlier than possible with the conventional clinical chemistry method of blood urea nitrogen (BUN) measurement...
January 4, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29295873/potentiating-tissue-resident-type-2-innate-lymphoid-cells-by-il-33-to-prevent-renal-ischemia-reperfusion-injury
#19
Qi Cao, Yiping Wang, Zhiguo Niu, Chengshi Wang, Ruifeng Wang, Zhiqiang Zhang, Titi Chen, Xin Maggie Wang, Qing Li, Vincent W S Lee, Qingsong Huang, Jing Tan, Minghao Guo, Yuan Min Wang, Guoping Zheng, Di Yu, Stephen I Alexander, Hui Wang, David C H Harris
The IL-33-type 2 innate lymphoid cell (ILC2) axis has an important role in tissue homeostasis, inflammation, and wound healing. However, the relative importance of this innate immune pathway for immunotherapy against inflammation and tissue damage remains unclear. Here, we show that treatment with recombinant mouse IL-33 prevented renal structural and functional injury and reduced mortality in mice subjected to ischemia-reperfusion injury (IRI). Compared with control-treated IRI mice, IL-33-treated IRI mice had increased levels of IL-4 and IL-13 in serum and kidney and more ILC2, regulatory T cells (Tregs), and anti-inflammatory (M2) macrophages...
January 2, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29275176/cxcl16-rock1-signaling-pathway-exacerbates-acute-kidney-injury-induced-by-ischemia-reperfusion
#20
Hua Liang, Meijuan Liao, Weicheng Zhao, Xueqin Zheng, Feng Xu, Hanbing Wang, Jian Huang
Renal ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI) resulting in an abrupt deterioration of kidney function. CXC chemokine ligand 16 (CXCL16) contributes significantly to the pathogenesis of renal injury. However, the signaling pathway mechanisms of CXCL16 in IRI-induced AKI remains obscured. In this study, we examined the role of the CXCL16/ Rho Associated Coiled-Coil Containing Protein Kinase-1 (ROCK1) signaling pathway in AKI induced by IRI. In vivo, CXCL16 was induced markedly after IRI...
December 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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