keyword
https://read.qxmd.com/read/37876811/the-role-of-hif-1%C3%AE-ho-1-pathway-in-hippocampal-neuronal-ferroptosis-in-epilepsy
#21
JOURNAL ARTICLE
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Epilepsy, a common central nervous system disorder, remains an enigma in pathogenesis. Emerging consensus designates hippocampal neuronal injury as a cornerstone for epileptogenic foci, pivotal in epileptic genesis and progression. Ferroptosis, a regulated cell death modality hinging on iron, catalyzes lipid reactive oxygen species formation through iron and membrane polyunsaturated fatty acid interplay, culminating in oxidative cell death. This research investigates the role of hypoxia-inducible factor (HIF)-1α/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy...
November 17, 2023: IScience
https://read.qxmd.com/read/37764107/a-fatal-a-h5n1-avian-influenza-virus-infection-in-a-cat-in-poland
#22
Olga Szaluś-Jordanow, Anna Golke, Tomasz Dzieciątkowski, Dorota Chrobak-Chmiel, Magdalena Rzewuska, Michał Czopowicz, Rafał Sapierzyński, Michał Kardas, Kinga Biernacka, Marcin Mickiewicz, Agata Moroz-Fik, Andrzej Łobaczewski, Ilona Stefańska, Ewelina Kwiecień, Iwona Markowska-Daniel, Tadeusz Frymus
A European Shorthair male cat, neutered, approximately 6 years of age, was presented to the veterinary clinic due to apathy and anorexia. The cat lived mostly outdoors and was fed raw chicken meat. After 3 days of diagnostic procedures and symptomatic treatment, respiratory distress and neurological signs developed and progressed into epileptic seizures, followed by respiratory and cardiac arrest within the next 3 days. Post-mortem examination revealed necrotic lesions in the liver, lungs, and intestines. Notably, the brain displayed perivascular infiltration of lymphocytes and histiocytes...
September 9, 2023: Microorganisms
https://read.qxmd.com/read/37739177/accuracy-and-utility-of-frameless-stereotactic-placement-of-stereoelectroencephalgraphy-electrodes
#23
JOURNAL ARTICLE
Cameron Brimley, Nir Shimony
INTRODUCTION: Successful surgery for epilepsy hinges on identification of the epileptogenic focus. Stereoelectroencephalgraphy is the most effective way to identify most seizure foci. There are multiple methods of inserting depth electrodes including frame-based, frameless, and robot assisted techniques. Studies have shown the accuracy of frame based and robot-assisted techniques to be statistically similar, while only one study details the frameless sEEG insertion technique. METHODS: Patients underwent placement of sEEG depth electrodes using frameless stereotaxy from September 2019 to September 2021 at Geisinger Medical Center by a single surgeon...
September 20, 2023: World Neurosurgery
https://read.qxmd.com/read/37728409/epileptic-versus-neuro-oncological-focus-of-management-in-pediatric-patients-with-concurrent-primary-brain-lesion-and-seizures-a-systematic-review
#24
JOURNAL ARTICLE
Maxwell D Gruber, Jonathan Pindrik, Mark Damante, Lauren Schulz, Ammar Shaikhouni, Jeffrey R Leonard
OBJECTIVE: Seizures can be a debilitating manifestation of underlying neoplastic intracranial pathology. Existing literature offers a paucity of scientific consensus regarding risk factors, seizure semiology, operative techniques, and tumor characteristics in pediatric patients with a concurrent diagnosis of primary intracranial neoplasm and seizures. To address the limited evidence in current literature, the authors systematically reviewed published literature on current clinical characteristics and management strategies for patients presenting concurrently with seizures and a newly diagnosed brain lesion, while aiming to synthesize a potential management protocol or set of recommendations for these patients...
August 11, 2023: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/37728285/radiofrequency-ablation-during-stereoelectroencephalography-from-diagnostic-tool-to-therapeutic-intervention-illustrative-case
#25
JOURNAL ARTICLE
Demitre Serletis, Juan Bulacio, Justin Bingaman, Elham Abushanab, Stephen P Harasimchuk, Richard Rammo, Silvia Neme-Mercante, William Bingaman
BACKGROUND: Radiofrequency thermocoagulation (RFTC) during intracranial stereoelectroencephalography (sEEG) was first described as a safe technique for creating lesions of epileptic foci in 2004. Since that time, the method has been applied as a diagnostic and/or palliative intervention. Although widely practiced in European epilepsy surgical programs, the technique has not been popularized in the United States given the lack of Food and Drug Administration (FDA)-approved technologies permitting safe usage of in situ sEEG electrodes for this purpose...
August 14, 2023: J Neurosurg Case Lessons
https://read.qxmd.com/read/37712215/the-differing-effects-of-sleep-on-ictal-and-interictal-network-dynamics-in-drug-resistant-epilepsy
#26
JOURNAL ARTICLE
Sana Hannan, John Thomas, Kassem Jaber, Charbel El Kosseifi, Alyssa Ho, Chifaou Abdallah, Tamir Avigdor, Jean Gotman, Birgit Frauscher
OBJECTIVE: Sleep has important influences on focal interictal epileptiform discharges (IEDs), and the rates and spatial extent of IEDs are increased in non-rapid eye movement (NREM) sleep. In contrast, the influence of sleep on seizures is less clear, and its effects on seizure topography are poorly documented. We evaluated the influences of NREM sleep on ictal spatiotemporal dynamics and contrasted these with interictal network dynamics. METHODS: We included patients with drug-resistant focal epilepsy who underwent continuous intracranial electroencephalography (iEEG) with depth electrodes...
September 15, 2023: Annals of Neurology
https://read.qxmd.com/read/37660659/a-reappraisal-of-interictal-eeg-characteristics-in-self-limited-epilepsy-with-autonomic-seizures-formerly-known-as-panayiotopoulos-syndrome-or-early-onset-benign-occipital-epilepsy
#27
REVIEW
Hirokazu Oguni
PURPOSE: In the 2022 New International Classification of Epilepsy Syndromes, self-limited epilepsy with autonomic seizures (SeLEAS), formerly known as Panayiotopoulos syndrome is recognized as an electroclinical syndrome that is clinically characterized by autonomic seizures and electroencephalographically by multifocal EEG foci. EEG studies were reviewed herein and the suitability of the EEG definition to characterize SeLEAS was assessed. METHODS AND RESULTS: The EEG findings of SeLEAS studies published to date were reviewed and typical sites of EEG foci and their evolutionary changes with age were analyzed...
November 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/37628870/neuroinflammatory-dysfunction-of-the-blood-brain-barrier-and-basement-membrane-dysplasia-play-a-role-in-the-development-of-drug-resistant-epilepsy
#28
JOURNAL ARTICLE
Yulia Zabrodskaya, Natalia Paramonova, Anastasia Litovchenko, Elena Bazhanova, Aleksandr Gerasimov, Darya Sitovskaya, Victoria Nezdorovina, Svetlana Kravtsova, Stanislav Malyshev, Ekaterina Skiteva, Konstantin Samochernykh
Drug-resistance epilepsy (DRE) is a key problem in neurology. It is possible that damage to the blood-brain barrier (BBB) may affect resistance in DRE. The aim of this work was to assess the damage and dysfunction in the BBB in the area of epileptic foci in patients with DRE under conditions of neuroinflammation. The changes to the BBB in temporal lobe epilepsy (by immunohistochemistry and transmission electron microscopy), levels of neuroinflammatory proteins, and cytokine levels in the blood (by multiplex analysis) were studied...
August 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37615416/an-artificial-intelligence-based-pipeline-for-automated-detection-and-localisation-of-epileptic-sources-from-magnetoencephalography
#29
JOURNAL ARTICLE
Li Zheng, Pan Liao, Xiuwen Wu, Miao Cao, Wei Cui, Lingxi Lu, Hui Xu, Linlin Zhu, Bingjiang Lyu, Xiongfei Wang, Pengfei Teng, Jing Wang, Simon Vogrin, Chris Plummer, Guoming Luan, Jia-Hong Gao
Objective. Magnetoencephalography (MEG) is a powerful non-invasive diagnostic modality for presurgical epilepsy evaluation. However, the clinical utility of MEG mapping for localising epileptic foci is limited by its low efficiency, high labour requirements, and considerable interoperator variability. To address these obstacles, we proposed a novel artificial intelligence-based automated magnetic source imaging (AMSI) pipeline for automated detection and localisation of epileptic sources from MEG data. Approach...
August 24, 2023: Journal of Neural Engineering
https://read.qxmd.com/read/37502686/magnetoencephalography-based-approaches-to-epilepsy-classification
#30
REVIEW
Ruoyao Pan, Chunlan Yang, Zhimei Li, Jiechuan Ren, Ying Duan
Epilepsy is a chronic central nervous system disorder characterized by recurrent seizures. Not only does epilepsy severely affect the daily life of the patient, but the risk of premature death in patients with epilepsy is three times higher than that of the normal population. Magnetoencephalography (MEG) is a non-invasive, high temporal and spatial resolution electrophysiological data that provides a valid basis for epilepsy diagnosis, and used in clinical practice to locate epileptic foci in patients with epilepsy...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/37491868/refining-the-electroclinical-spectrum-of-nprl3-related-epilepsy-a-novel-multiplex-family-and-literature-review
#31
REVIEW
Alice Dainelli, Michele Iacomino, Sara Rossato, Samuela Bugin, Monica Traverso, Mariasavina Severino, Stefano Gustincich, Valeria Capra, Marco Di Duca, Federico Zara, Marcello Scala, Pasquale Striano
OBJECTIVE: NPRL3-related epilepsy (NRE) is an emerging condition set within the wide GATOR-1 spectrum with a particularly heterogeneous and elusive phenotypic expression. Here, we delineated the genotype-phenotype spectrum of NRE, reporting an illustrative familial case and reviewing pertinent literature. METHODS: Through exome sequencing (ES), we investigated a 12-year-old girl with recurrent focal motor seizures during sleep, suggestive of sleep-related hypermotor epilepsy (SHE), and a family history of epilepsy in siblings...
December 2023: Epilepsia Open
https://read.qxmd.com/read/37450928/mitochondrial-dysfunction-of-astrocytes-mediates-lipid-accumulation-in-temporal-lobe-epilepsy
#32
REVIEW
Yang Su, Meng Tang, Minjin Wang
Lipid-accumulated reactive astrocytes (LARAs) have recently been confirmed to be a pivotal cell type present in temporal lobe epilepsy (TLE) lesions. These cells not only induce anomalous lipid accumulation within the epileptic foci but also decrease the seizure threshold by employing upregulated activation of the adenosine A2A receptor (A2AR). Furthermore, disturbances in mitochondrial oxidative phosphorylation (OxPhos) have been noted as significant drivers of lipid accumulation in astrocytes. Moreover, the deficiency of OxPhos in astrocytes can induce severe neuroinflammation, which can worsen the progression of TLE...
July 11, 2023: Aging and Disease
https://read.qxmd.com/read/37448751/seizures-regulate-the-cation-cl-cotransporter-nkcc1-in-a-hamster-model-of-epilepsy-implications-for-gaba-neurotransmission
#33
JOURNAL ARTICLE
Juan-Manuel Bonet-Fernández, Pedro Tranque, Jose Daniel Aroca-Aguilar, Luis J Muñoz, Dolores E López, Julio Escribano, Carlos de Cabo
BACKGROUND: The balance between the activity of the Na+ /K+ /Cl- cotransporter (NKCC1) that introduces Cl- into the cell and the K+ /Cl- cotransporter (KCC2) that transports Cl- outside the cell is critical in determining the inhibitory or excitatory outcome of GABA release. Mounting evidence suggests that the impairment of GABAergic inhibitory neurotransmission plays a crucial role in the pathophysiology of epilepsy, both in patients and animal models. Previous studies indicate that decreased KCC2 expression is linked to audiogenic seizures in GASH/Sal hamsters, highlighting that Cl- imbalance can cause neuronal hyperexcitability...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37373384/delayed-biotin-therapy-in-a-child-with-atypical-profound-biotinidase-deficiency-late-arrival-of-the-truth-and-a-lesson-worth-thinking
#34
Shu Liu, Ye Zhang, Zhi Deng, Hui He, Xianhua Zheng, Qingshan Hong, Xianqiong Luo
Biotinidase (BTD) deficiency (OMIM 253260) is an autosomal recessively inherited metabolic disorder resulting from deficient activity of the BTD enzyme, which can cleave and release biotin from a variety of biotin-dependent carboxylases, and is therefore recognized as a tool to recycle biotin. Being a condition caused by variations on BTD gene with a consequence of free biotin shortage, BTD deficiency may impair the activity of biotin-dependent carboxylases, and thus bring about a buildup of potentially toxic compounds in the body, primarily 3-hydroxyisovaleryl-carnitine in plasma as well as 3-hydroxyisovaleric acid in urine...
June 16, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37308790/the-clinical-application-of-neuro-robot-in-the-resection-of-epileptic-foci-a-novel-method-assisting-epilepsy-surgery
#35
RANDOMIZED CONTROLLED TRIAL
Yichen Xu, Yingchuan Chen, Huanguang Liu, Hua Zhang, Zixiao Yin, Defeng Liu, Guanyu Zhu, Yu Diao, Delong Wu, Hutao Xie, Wenhan Hu, Xin Zhang, Xiaoqiu Shao, Kai Zhang, Jianguo Zhang, Anchao Yang
During surgery for foci-related epilepsy, neurosurgeons face significant difficulties in identifying and resecting MRI-negative or deep-seated epileptic foci. Here, we present a neuro-robotic navigation system that is specifically designed for resection of MRI negative epileptic foci. We recruited 52 epileptic patients, and randomly assigned them to treatment group with either neuro-robotic navigation or conventional neuronavigation system. For each patient, in the neuro-robotic navigation group, we integrated multimodality imaging including MRI and PET-CT into the robotic workstation and marked the boundary of foci from the fused image...
October 2023: Journal of Robotic Surgery
https://read.qxmd.com/read/37211733/-electrocorticography-recorded-from-subdural-electrodes-and-stereo-electroencephalography
#36
JOURNAL ARTICLE
Haruhiko Kishima, Hui Ming Khoo, Naoki Tani, Satoru Oshino
Epilepsy surgeons often encounter drug-resistant focal epilepsy, which needs to be diagnosed so that the epileptic foci can be identified and the patient treated. When noninvasive preoperative evaluation cannot determine the region of seizure onset or eloquent cortical areas, invasive epileptic video-EEG monitoring using intracranial electrodes needs to be applied. While subdural electrodes have been used to accurately identify epileptogenic foci via electrocorticography for some time, the use of stereo-electroencephalography has recently exploded in Japan, due to its less invasive nature and its better ability to reveal epileptogenic networks...
May 2023: No Shinkei Geka. Neurological Surgery
https://read.qxmd.com/read/37151228/spike-microstates-correlate-with-interictal-epileptogenic-discharges-a-marker-for-hidden-epileptic-activity
#37
JOURNAL ARTICLE
Vincent Rochas, Markus Gschwind, Krassen Nedeltchev, Margitta Seeck
Objectively estimating disease severity and treatment success is a main problem in outpatient managing of epilepsy. Self-reported seizures diaries are well-known to underestimate the actual seizure count, and repeated EEGs might not show interictal epileptiform discharges (IEDs), although patients suffer from seizures. In this prospective study, we investigate the potential of microstate analysis to monitor epilepsy patients independently of their IED count. From our databank of candidates for epilepsy surgery, we included 18 patients who underwent controlled resting EEG sessions (with eyes closed, 30 min), at around the same time of the day, during at least four days (range: 4-8 days; mean: 5)...
2023: Brain communications
https://read.qxmd.com/read/37098192/principles-of-patients-selection-and-safety-of-repetitive-transcranial-magnetic-stimulation-position-statement-of-the-section-of-biological-psychiatry-of-the-polish-psychiatric-association
#38
Jakub Maria Antczak, Weronika Dębowska, Anna Poleszczyk, Jakub Kaźmierski, Joanna Rymaszewska, Napoleon Waszkiewicz, Adam Wichniak
Transcranial magnetic stimulation (TMS) is a method of noninvasive brain stimulation developed since the 1980s. Repetitive transcranial magnetic stimulation (rTMS) is one of the methods of noninvasive brain stimulation, which is increasingly used to treat psychiatric disorders. Recent years witnessed a dynamic growth in the number of sites offering therapy with rTMS and of the interest of patients in this method in Poland. This article presents the position statement of the working group of the Section of Biological Psychiatry of the Polish Psychiatric Association concerning the proper patients selection and safety of use of rTMS in the therapy of psychiatric conditions...
December 31, 2022: Psychiatria Polska
https://read.qxmd.com/read/37062539/thalamostriatal-disconnection-underpins-long-term-seizure-freedom-in-frontal-lobe-epilepsy-surgery
#39
JOURNAL ARTICLE
Davide Giampiccolo, Lawrence P Binding, Lorenzo Caciagli, Roman Rodionov, Chris Foulon, Jane de Tisi, Alejandro Granados, Roisin Finn, Debayan Dasgupta, Fenglai Xiao, Beate Diehl, Emma Torzillo, Jan Van Dijk, Peter N Taylor, Matthias Koepp, Andrew W McEvoy, Sallie Baxendale, Fahmida Chowdhury, John S Duncan, Anna Miserocchi
Around 50% of patients undergoing frontal lobe surgery for focal drug-resistant epilepsy become seizure free post-operatively; however, only about 30% of patients remain seizure free in the long-term. Early seizure recurrence is likely to be caused by partial resection of the epileptogenic lesion, whilst delayed seizure recurrence can occur even if the epileptogenic lesion has been completely excised. This suggests a coexistent epileptogenic network facilitating ictogenesis in close or distant dormant epileptic foci...
June 1, 2023: Brain
https://read.qxmd.com/read/37062236/static-and-temporal-dynamic-alteration-of-intrinsic-brain-activity-in-mri-negative-temporal-lobe-epilepsy
#40
JOURNAL ARTICLE
Chengru Song, Xiaonan Zhang, Shaoqiang Han, Yajun Lian, Keran Ma, Kefan Wang, Xinyue Mao, Yong Zhang, Jingliang Cheng
PURPOSE: To comprehensively explore the potential brain activity abnormalities affected by MRI-negative temporal lobe epilepsy (TLE) and to detect whether the changes were associated with cognition and help in the diagnosis or lateralization. METHOD: Six static intrinsic brain activity (IBA) indicators (ALFF, fALFF, ReHo, DC, GSCorr, VMHC) and their corresponding six temporal dynamic indicators in 39 unilateral MRI-negative TLE patients and 42 healthy volunteers were compared...
May 2023: Seizure: the Journal of the British Epilepsy Association
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