keyword
MENU ▼
Read by QxMD icon Read
search

shafi

keyword
https://www.readbyqxmd.com/read/28718245/left-ventricular-systolic-dysfunction-predicted-by-early-troponin-i-release-after-anthracycline-based-chemotherapy-in-breast-cancer-patients
#1
Azhar Shafi, Neelam Siddiqui, Saba Imtiaz, Mansoor Ud Din Sajid
BACKGROUND: Anthracyclines are one of the most effective chemotherapeutic agents in management of Breast cancer, however Anthracycline induced cardiotoxicity remains a matter of special concern. Detection of early toxicity by use of biomarkers like Troponins has been the focus of interest in recent years. We measured Troponin I levels after chemotherapy with anthracyclines and correlated it with ECG, Echocardiography and clinical findings. METHODS: Patients with early Breast cancer eligible for chemotherapy were included in the study...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712176/ecg-abnormalities-in-patients-with-chronic-kidney-disease
#2
Salman Shafi, Mohammad Saleem, Roshina Anjum, Wajid Abdullah, Tahir Shafi
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease. Electrocardiographic (ECG) abnormalities are common in CKD patients. However, there is variation in literature regarding frequency of ECG abnormalities in CKD patients and limited information in local population. METHODS: The study design was cross-sectional in nature. All patients between ages of 20-80 years with CKD not previously on renal replacement therapy who were admitted to nephrology ward at a tertiary care facility over a 6-month period were included...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28686441/a-direct-alcohol-fuel-cell-driven-by-an-outer-sphere-positive-electrode
#3
Zahid Manzoor Bhat, Ravikumar Thimmappa, Mruthyunjayachari Chattanahalli Devendrachari, Shahid Pottachola Shafi, Shambhulinga Aralekallu, Alagar Raja Kottaichamy, Manu Gautam, Musthafa Ottakam Thotiyl
Molecular oxygen, the conventional electron acceptor in fuel cells poses challenges specific to direct alcohol fuel cells (DAFCs). Due to the coupling of alcohol dehydrogenation with the scission of oxygen on the positive electrode during the alcohol crossover, the benchmark Pt-based air cathode experiences severe competition and depolarization losses. The necessity of heavy precious metal loading with domains for alcohol tolerance in the state of the art DAFC cathode is a direct consequence of this. Though efforts are dedicated to selectively cleave oxygen, the root of the problem being the inner sphere nature of either half-cell chemistry is often overlooked...
July 7, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28679363/incremental-short-daily-home-hemodialysis-a-case-series
#4
Stephanie M Toth-Manikowski, Surekha Mullangi, Seungyoung Hwang, Tariq Shafi
BACKGROUND: Patients starting dialysis often have substantial residual kidney function. Incremental hemodialysis provides a hemodialysis prescription that supplements patients' residual kidney function while maintaining total (residual + dialysis) urea clearance (standard Kt/Vurea) targets. We describe our experience with incremental hemodialysis in patients using NxStage System One for home hemodialysis. CASE PRESENTATION: From 2011 to 2015, we initiated 5 incident hemodialysis patients on an incremental home hemodialysis regimen...
July 5, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28676108/incidence-prevalence-and-mortality-rates-of-malaria-in-ethiopia-from-1990-to-2015-analysis-of-the-global-burden-of-diseases-2015
#5
Amare Deribew, Tariku Dejene, Biruck Kebede, Gizachew Assefa Tessema, Yohannes Adama Melaku, Awoke Misganaw, Teshome Gebre, Asrat Hailu, Sibhatu Biadgilign, Alemayehu Amberbir, Biruck Desalegn Yirsaw, Amanuel Alemu Abajobir, Oumer Shafi, Semaw F Abera, Nebiyu Negussu, Belete Mengistu, Azmeraw T Amare, Abate Mulugeta, Birhan Mengistu, Zerihun Tadesse, Mesfin Sileshi, Elizabeth Cromwell, Scott D Glenn, Kebede Deribe, Jeffrey D Stanaway
BACKGROUND: In Ethiopia there is no complete registration system to measure disease burden and risk factors accurately. In this study, the 2015 global burden of diseases, injuries and risk factors (GBD) data were used to analyse the incidence, prevalence and mortality rates of malaria in Ethiopia over the last 25 years. METHODS: GBD 2015 used verbal autopsy surveys, reports, and published scientific articles to estimate the burden of malaria in Ethiopia. Age and gender-specific causes of death for malaria were estimated using cause of death ensemble modelling...
July 4, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28671710/adult-xanthogranuloma-diagnosed-on-reflectance-confocal-microscopy
#6
Attiya Haroon, Shahram Shafi, Babar Rao
No abstract text is available yet for this article.
July 3, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28670898/redox-active-binary-logic-gate-circuit-for-homeland-security
#7
Pramod Gaikwad, Kavita Kadlag, Manasa Nambiar, Mruthyunjayachari Chattanahalli Devendrachari, Shambhulinga Aralekallu, Alagar Raja Kottaichamy, Zahid Manzoor Bhat, Ravikumar Thimmappa, Shahid Pottachola Shafi, Musthafa Ottakam Thotiyl
Bipolar junction transistors are at the frontiers of modern electronics owing to their discrete voltage regulated operational levels. Here we report a redox active binary logic gate (RLG) which can store a "0" and "1" with distinct operational levels, albeit without an external voltage stimuli. In the RLG, a shorted configuration of half-cell electrodes provided the logic low level and decoupled configuration relaxed the system to the logic high level due to self-charge injection into the redox active polymeric system...
July 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28666279/sodium-iodate-produces-a-strain-dependent-retinal-oxidative-stress-response-measured-in-vivo-using-quest-mri
#8
Bruce A Berkowitz, Robert H Podolsky, Jacob Lenning, Nikita Khetarpal, Catherine Tran, Johnny Y Wu, Ali M Berri, Kristin Dernay, Fatema Shafie-Khorassani, Robin Roberts
Purpose: We identify noninvasive biomarkers that measure the severity of oxidative stress within retina layers in sodium iodate (SI)-atrophy vulnerable (C57BL/6 [B6]) and SI-atrophy resistant (129S6/SvEvTac [S6]) mice. Methods: At 24 hours after administering systemic SI to B6 and S6 mice we measured: (1) superoxide production in whole retina ex vivo, (2) excessive free radical production in vivo based on layer-specific 1/T1 values before and after α-lipoic acid (ALA) administration while the animal was inside the magnet (QUEnch-assiSTed MRI [QUEST MRI]), and (3) visual performance (optokinetic tracking) ± antioxidants; control mice were similarly assessed...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28665402/germline-bap1-mutations-induce-a-warburg-effect
#9
Angela Bononi, Haining Yang, Carlotta Giorgi, Simone Patergnani, Laura Pellegrini, Mingming Su, Guoxiang Xie, Valentina Signorato, Sandra Pastorino, Paul Morris, Greg Sakamoto, Shafi Kuchay, Giovanni Gaudino, Harvey I Pass, Andrea Napolitano, Paolo Pinton, Wei Jia, Michele Carbone
Carriers of heterozygous germline BAP1 mutations (BAP1(+/-)) develop cancer. We studied plasma from 16 BAP1(+/-) individuals from 2 families carrying different germline BAP1 mutations and 30 BAP1 wild-type (BAP1(WT)) controls from these same families. Plasma samples were analyzed by liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS), ultra-performance liquid chromatography triple quadrupole mass spectrometry (UPLC-TQ-MS), and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS). We found a clear separation in the metabolic profile between BAP1(WT) and BAP1(+/-) individuals...
June 30, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28658837/leriche-syndrome-acute-onset-painful-paraplegia-of-vascular-origin-with-catastrophic-consequences
#10
Sampathkumar Mahadevappa Mahendrakar, Harpreet Singh Sandhu, Azizullah Hafizullah Khan, Yunus Shafi Loya
Acute Aorto-Iliac Occlusive Disease (AIOD) is a rare clinical entity which when presents with buttock claudication, erectile dysfunction and absent femoral pulses is termed as Leriche syndrome. A 59-year-old male patient with past history of smoking and dyslipidaemia presented with acute onset lower back pain, paraplegia, intense lower limb pain and was initially evaluated for compressive myelopathy. On further clinical examination there were absent femoral pulses and Computed Tomography (CT) aortogram was done which confirmed the diagnosis of diffuse AIOD...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28653924/screening-of-leaves-extracts-from-calamus-aromaticus-for-their-antimicrobial-activity-by-disc-diffusion-assay
#11
Bilal Muhammad Khan, Jehan Bakht, Mohammad Shafi
The current research investigates the anti-microbial activities of different solvent extracted samples from the leaves of Calamus aromaticus against Gram positive, Gram negative bacteria and fungi using 500, 1000 and 2000 μg disc(-1) concentrations. Escherichia coli, Citorbacter freundii and Candida albicans showed resistivity to crude methanolic extract and the same microbes were more susceptible to water extracted fractions. Maximum activity was measured by hexane extracted fractions against Pseudomonas aeruginosa, Bacillus subtilis and Xanthomonas campestris and minimum growth inhibition by water extracted fractions...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28647882/leaching-of-phthalate-esters-from-different-drinking-stuffs-and-their-subsequent-biodegradation
#12
Muhammad Ali Surhio, Farah N Talpur, Shafi M Nizamani, Marvi Kanwal Talpur, Hassan Imran Afridi, Abid Ali Khaskheli, Shazia Bhurgri, Junaid Ali Surhio
Phthalate esters (PAEs) are mainly used as plasticizers, and their release in the environment during the manufacturing, use, and disposal has caused serious environmental health concerns, since some of them are suspected to be mutagens, hepatotoxic agents, and carcinogens. In the present study, leaching of PAEs from different drinking stuffs (water cooler, mineral water bottles) exposed to sunlight and baby feeders subjected to different heating treatments (boiling, autoclave and oven) was studied. Results showed that a total of 10 PAEs were leached and identified...
June 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28631373/the-risk-of-violence-associated-with-novel-psychoactive-substance-misuse-in-patients-presenting-to-acute-mental-health-services
#13
Abu Shafi, Paul Gallagher, Neil Stewart, Giovanni Martinotti, Ornella Corazza
Novel psychoactive substance (NPS) availability is increasing at a phenomenal rate and so is their associated misuse. Currently, the harms associated with NPS misuse are unclear. This report presents the initial findings of a continuing study looking into the impact of NPS misuse on admissions to an acute mental health facility in London. Violence preadmission and violence during admission have been found to be significant in NPS misusers compared to non-NPS substance misusers. Our findings have important consequences for acute mental health, emergency, and public health services...
June 19, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28622826/gstp1-and-xrcc1-polymorphisms-and-dna-damage-in-agricultural-workers-exposed-to-pesticides
#14
Amal Saad-Hussein, Magda Noshy, Mona Taha, Haidan El-Shorbagy, Eman Shahy, Ebtesam A Abdel-Shafy
Pesticide exposure may be associated with increased risk of genotoxicity and carcinogenesis. These risks may be affected by polymorphisms of genes for glutathione transferase-dependent metabolism of pesticides and for DNA repair. We studied the prevalence of GSTP1 and XRCC1 polymorphisms and their possible correlation with DNA damage following prolonged pesticide exposure. DNA damage was estimated by the comet assay in peripheral blood samples from 51 pesticide-exposed workers and 50 controls. GSTP1 (105) and XRCC1 (399 and 194) genotypes were identified by restriction fragment length analysis...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28619714/the-g-protein-coupled-receptor-gpr31-promotes-membrane-association-of-kras
#15
Nicole Fehrenbacher, Israel Tojal da Silva, Craig Ramirez, Yong Zhou, Kwang-Jin Cho, Shafi Kuchay, Jie Shi, Susan Thomas, Michele Pagano, John F Hancock, Dafna Bar-Sagi, Mark R Philips
The product of the KRAS oncogene, KRAS4B, promotes tumor growth when associated with the plasma membrane (PM). PM association is mediated, in part, by farnesylation of KRAS4B, but trafficking of nascent KRAS4B to the PM is incompletely understood. We performed a genome-wide screen to identify genes required for KRAS4B membrane association and identified a G protein-coupled receptor, GPR31. GPR31 associated with KRAS4B on cellular membranes in a farnesylation-dependent fashion, and retention of GPR31 on the endoplasmic reticulum inhibited delivery of KRAS4B to the PM...
June 15, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28615833/prevalence-and-organwise-distribution-of-sarcocystiosis-in-buffaloes-of-mohali-punjab
#16
Khadim Hussain Dar, Mohd Mansoor Bhat, Majid Shafi
The study was carried at Mirha Exports private limited at Mohali, Punjab, from December 2012 to May 2013 during which 1000 buffaloes of 2-3 years of age slaughtered for meat purposes were screened for the Sarcocystis species. Most of the animals examined at anti-mortem appeared normal and clinically healthy. However, at slaughtering, the gross and microscopic examination of representative samples of striated muscles collected from slaughtered buffaloes revealed 95.50 % prevalence of Sarcocystis species. Out of 1000 samples examined, 955 samples (95...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28614305/bap1-regulates-ip3r3-mediated-ca-2-flux-to-mitochondria-suppressing-cell-transformation
#17
Angela Bononi, Carlotta Giorgi, Simone Patergnani, David Larson, Kaitlyn Verbruggen, Mika Tanji, Laura Pellegrini, Valentina Signorato, Federica Olivetto, Sandra Pastorino, Masaki Nasu, Andrea Napolitano, Giovanni Gaudino, Paul Morris, Greg Sakamoto, Laura K Ferris, Alberto Danese, Andrea Raimondi, Carlo Tacchetti, Shafi Kuchay, Harvey I Pass, El Bachir Affar, Haining Yang, Paolo Pinton, Michele Carbone
BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1(+/-)) developed one and often several BAP1(-/-) malignancies in their lifetime, mostly malignant mesothelioma, uveal melanoma, and so on. Moreover, BAP1-acquired biallelic mutations are frequent in human cancers. BAP1 tumour suppressor activity has been attributed to its nuclear localization, where it helps to maintain genome integrity...
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28614300/pten-counteracts-fbxl2-to-promote-ip3r3-and-ca-2-mediated-apoptosis-limiting-tumour-growth
#18
Shafi Kuchay, Carlotta Giorgi, Daniele Simoneschi, Julia Pagan, Sonia Missiroli, Anita Saraf, Laurence Florens, Michael P Washburn, Ana Collazo-Lorduy, Mireia Castillo-Martin, Carlos Cordon-Cardo, Said M Sebti, Paolo Pinton, Michele Pagano
In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca(2+) release results in mitochondrial Ca(2+) overload and consequent apoptosis. Among the three mammalian IP3Rs, IP3R3 appears to be the major player in Ca(2+)-dependent apoptosis. Here we show that the F-box protein FBXL2 (the receptor subunit of one of 69 human SCF (SKP1, CUL1, F-box protein) ubiquitin ligase complexes) binds IP3R3 and targets it for ubiquitin-, p97- and proteasome-mediated degradation to limit Ca(2+) influx into mitochondria...
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28610706/ultrasound-guided-bilateral-rectus-sheath-block-vs-conventional-local-analgesia-in-single-port-laparoscopic-appendectomy-for-children-with-nonperforated-appendicitis
#19
Caroline Maloney, Michelle Kallis, Ibrahim Abd El-Shafy, Aaron M Lipskar, John Hagen, Michelle Kars
INTRODUCTION: Despite its minimally invasive approach, laparoscopic surgery can cause considerable pain. Regional analgesic techniques such as the rectus sheath block (RSB) offer improved pain management following elective umbilical hernia repair in the pediatric population. This effect has not been examined in laparoscopic single-incision surgery in children. We sought to compare the efficacy of bilateral ultrasound-guided RSB versus local anesthetic infiltration (LAI) in providing postoperative pain relief in pediatric single-incision transumbilical laparoscopic assisted appendectomy (TULA) with same-day discharge...
June 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28603109/phytochemical-and-biological-assessments-on-lipidium-meyenii-maca-and-epimidium-sagittatum-horny-goat-weed
#20
Mahmood Qureshi, - Mehjabeen, - Noorjahan, Shafi Muhammad, Faheem Ahmed Siddiqui, Iftikhar Baig, Mansoor Ahmad
The effects of Lipidium meyenii (maca, LM) and Epimidium sagittatum (horny goat weed, ES) have been investigated due to their involvement in fertilization. Both of the drugs showed good results before, during and after fertilization in male and female mice. The results revealed that the crude extract of Lipidium meyenii caused a significant decrease in the no. of writhes at 300 and 500mg/kg (p<0.05) as compare to control, Epimidium sagittatum and standard drug. The gross behavioral, open field, exploratory behaviour, forced swimming test for stress, diuretic activity, chronic toxicity with the effect on reproduction of both male and female and change in body weight were also studied...
January 2017: Pakistan Journal of Pharmaceutical Sciences
keyword
keyword
33447
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"