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Musaib Ahmad Dar, Fahad Shafi, Jan Muhammad Suhail, Mohammad Arif Wani, Mohammad Yaqoob Wani, Naseer Ahmad Choh
No abstract text is available yet for this article.
May 2018: Neurology India
Bruce J Bolt, Faye H Rodgers, Myriam Shafie, Paul J Kersey, Matthew Berriman, Kevin L Howe
WormBase ParaSite ( ) is a comprehensive resource for the genomes of parasitic nematodes and flatworms (helminths). It currently includes genomic data for over 100 helminth species, adding value by way of consistent functional annotation, gene comparative analysis and gene expression analysis. We provide several ways of exploring the data including a choice of genome browsers, genome and gene summary pages, text and sequence searching, a query wizard, bulk downloads, and programmatic interfaces...
2018: Methods in Molecular Biology
Rami A El Shafie, Maja Czech, Kerstin A Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus, Stephanie E Combs
BACKGROUND: With the advance of modern irradiation techniques, the role of radiotherapy (RT) for intracranial meningioma has increased significantly throughout the past years. Despite that tumor's generally favorable outcome with local control rates of up to 90% after ten years, progression after RT does occur. In those cases, re-irradiation is often difficult due to the limited radiation tolerance of the surrounding tissue. The aim of this analysis is to determine the value of particle therapy with its better dose conformity and higher biological efficacy for re-irradiating recurrent intracranial meningioma...
May 8, 2018: Radiation Oncology
Morgan E Grams, Tariq Shafi, Eugene P Rhee
No abstract text is available yet for this article.
May 3, 2018: Journal of the American Society of Nephrology: JASN
Neda Tahmasebi, Bijan Shafie, Hamid Karimi, Masood Mazaheri
PURPOSE: The fourth version of the Stuttering Severity Instrument (SSI-4) has been available since 2009. It has some modifications and new features which make it more appropriate at least for clinical practice, although further documentation is needed. The objective of the current research was to translate SSI-4 into Persian language and to discuss its relative and absolute reliability as well as its criterion validity for Persian adults who stutter (PWS). We also aimed to study how the new subjective self-reports of the SSI-4 complement the stuttering severity score obtained from the SSI-3 or the SSI-4...
April 23, 2018: Journal of Communication Disorders
Shafi Sahibzada, Marta Hernández-Jover, David Jordan, Peter C Thomson, Jane Heller
BACKGROUND: The occurrence of livestock-associated (LA) MRSA (ST398) in pig herds has emerged as a threat to occupational safety in many parts of the world. Recently, an outbreak of skin lesions due to MRSA occurred in workers at a pig farm in regional Australia and both the humans and pigs were shown to have a high prevalence of carriage of either the human-strain ST93 or porcine strain ST398. This study closely scrutinises this outbreak to determine factors associated with MRSA carriage amongst the workers...
2018: PloS One
Josef Coresh, Lesley A Inker, Yingying Sang, Jingsha Chen, Tariq Shafi, Wendy S Post, Michael G Shlipak, Lisa Ford, Kelli Goodman, Regis Perichon, Tom Greene, Andrew S Levey
Background: Estimation of glomerular filtration rate (GFR) using estimated glomerular filtration rate creatinine (eGFRcr) is central to clinical practice but has limitations. We tested the hypothesis that serum metabolomic profiling can identify novel markers that in combination can provide more accurate GFR estimates. Methods: We performed a cross-sectional study of 200 African American Study of Kidney Disease and Hypertension (AASK) and 265 Multi-Ethnic Study of Atherosclerosis (MESA) participants with measured GFR (mGFR)...
April 30, 2018: Nephrology, Dialysis, Transplantation
Rafi Ullah, Jehan Bakht, Mohammad Shafi
The present study investigates the phyto-chemical analysis, phytotoxic activity and insecticidal activity of the stem and root tissues of medicinally important Periploca hydaspidis. All the extracted samples exhibited the phytotoxic activity. The data confirmed that water was the best solvent to extract the phytotoxic compounds from stem and root tissues. Roots extracted with different solvents exhibited better phytotoxic potential than samples obtained from the stem tissues. Samples extracted in methanol and water from both stems and roots tissues were active against the subject insects while hexane, ethyl acetate and butanol extracted samples in both parts exhibited no insecticidal activity...
May 2018: Pakistan Journal of Pharmaceutical Sciences
Xiaowei Zhang, Bin Zhong, Mohammad Shafi, Jia Guo, Chen Liu, Hua Guo, Danli Peng, Ying Wang, Dan Liu
The effect of EDTA and citric acid on accumulation, toxicity of heavy metals (Cu, Zn, Cd, and Pb), and growth of Moso bamboo was investigated in current experiment. The availability of heavy metals in soil and its uptake by plants has indicated toxicity. The results revealed that EDTA and citric acid has reduced biomass of Moso bamboo but non-significant difference in biomass was observed compared with control. Application of EDTA (10 mmol kg-1 ) has significantly improved copper (Cu) by 56.5 and 84.9% in roots and above ground parts of plants...
April 30, 2018: Environmental Science and Pollution Research International
Lili Shafie, Sara Esmaili, Masoud Parirokh, Abbas Pardakhti, Nouzar Nakhaee, Paul V Abbott, Hamide Barghi
Introduction: Pain management following dental procedures, particularly pulpotomies and extraction, is of great importance in pediatric dentistry. The aim of this study was to investigate the efficacy of pre-treatment with ibuprofen on post-operative pain following pulpotomy of primary molars. Methods and Materials: In a split mouth double-blinded randomized clinical trial, 49 children aging between 6-10 years old were given either ibuprofen or a placebo 45 min prior to the treatment...
2018: Iranian Endodontic Journal
Raman Preet Kaur, Gowhar Shafi, Raja Paramjeet Singh Benipal, Anjana Munshi
In this study, we evaluated the incidence of pathogenic germline mutations in 30 breast cancer susceptibility genes in breast cancer patients. Our aim was to understand the involvement of the inherited mutations in these genes in a breast cancer cohort. Two hundred ninety-six female breast cancer patients including 4.5% of familial breast cancer cases were included in the study. 200 ng of genomic DNA was used to evaluate the pathogenic mutations, detected using Global Screening Array (GSA) microchip (Illumina Inc...
April 26, 2018: Medical Oncology
Alimuddin Zumla, Esam I Azhar, David S Hui, Shuja Shafi, Eskild Petersen, Ziad A Memish
No abstract text is available yet for this article.
May 2018: Lancet Infectious Diseases
Hamideh Safi-Aghdam, Mehrzad Shafie, Alireza Khoshdel, Ehsan Moazen-Zadeh, Farhad Avakh, Arash Rahmani
We investigated the association between exposure to chemical warfare and chronic mental/physical conditions. This was a secondary analysis of data from a case-control study on Iranian male veterans. Participants with neuropsychiatric disorders other than depressive/anxiety disorders, anatomical defects, or malignancies were excluded. Compared to non-exposed veterans, exposed veterans demonstrated significantly higher odds of PTSD [OR (95% CI) = 5.23 (1.98-13.85)], hypertension [OR (95% CI) = 5.57 (1.68-18...
April 24, 2018: Community Mental Health Journal
Neethu Christudas Dargily, Ravikumar Thimmappa, Zahid Manzoor Bhat, Mruthyunjayachari Chattanahalli Devendrachari, Alagar Raja Kottaichamy, Manu Gautam, Shahid Pottachola Shafi, Musthafa Ottakam Thotiyl
We utilize the proton coupled electron transfer in hydrogen storage molecules to unlock a rechargeable battery chemistry based on the cleanest chemical energy carrier molecule hydrogen. Electrochemical, spectroscopic and spectroelectrochemical analysis evidence the participation of protons during the charge-discharge chemistry and extended cycling. In an era of anthropogenic global climate change and paramount pollution, a battery concept based on virtually non-polluting energy carrier molecule demonstrates a distinct progress in the sustainable energy landscape...
April 24, 2018: Journal of Physical Chemistry Letters
Yunjue Zhang, Mythily Subramaniam, Siau Pheng Lee, Edimansyah Abdin, Vathsala Sagayadevan, Anitha Jeyagurunathan, Sherilyn Chang, Saleha Binte Shafie, Restria Fauziana, Binte Abdul Rahman, Janhavi Ajit Vaingankar, Siow Ann Chong
Affiliated stigma often refers to internalized stigma among family members of stigmatized individuals. This study aimed to investigate the relationship between affiliate stigma and quality of life (QOL) among primary caregivers of individuals with mental illness undergoing treatment at the Institute of Mental Health, Singapore. Three hundred and fifty caregivers were recruited for the study. The World Health Organization Quality of Life questionnaire (WHOQOL-BREF) and Family Stigma Scale (FSS) were administered to the primary caregivers of patients with mental illness...
April 13, 2018: Psychiatry Research
Mythily Subramaniam, Hui Lin Ong, Edimansyah Abdin, Boon Yiang Chua, Saleha Shafie, Fiona Devi Siva Kumar, Sophia Foo, Li Ling Ng, Alvin Lum, Janhavi A Vaingankar, Siow Ann Chong
The number of people living with dementia is increasing globally as a result of an ageing population. General practitioners (GPs), as the front-line care providers in communities, are important stakeholders in the system of care for people with dementia. This commentary describes a study conducted to understand GPs' attitudes and self-perceived competencies when dealing with patients with dementia and their caregivers in Singapore. A set of study information sheet and survey questionnaires were mailed to selected GP clinics in Singapore...
March 2018: Annals of the Academy of Medicine, Singapore
Eric S Rosenthal, Siddharth Biswal, Sahar F Zafar, Kathryn L O'Connor, Sophia Bechek, Apeksha V Shenoy, Emily J Boyle, Mouhsin M Shafi, Emily J Gilmore, Brandon P Foreman, Nicolas Gaspard, Thabele M Leslie-Mazwi, Jonathan Rosand, Daniel B Hoch, Cenk Ayata, Sydney S Cash, Andrew J Cole, Aman B Patel, M Brandon Westover
OBJECTIVE: Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI is a key focus of neurocritical care, but interventions carry risk and cannot be applied indiscriminately. While retrospective studies have identified continuous EEG (cEEG) measures associated with DCI, no study has characterized the accuracy of cEEG with sufficient rigor to justify using it to triage patients to interventions or clinical trials. We therefore prospectively assessed the accuracy of cEEG for predicting DCI, following the Standards for Reporting Diagnostic Accuracy Studies...
April 16, 2018: Annals of Neurology
Shoaib Shafi, Tayyaba Faisal, Sajida Naseem, Sajida Javed, Haider Ghazanfar
Introduction An understanding of epidemiology is fundamental for designing research and understanding evidence-based medicine (EBM). The purpose of our study was to determine the knowledge of epidemiology among postgraduate medical trainees. Methods We carried out a cross-sectional study from January 2017 to June 2017 at the Regional Centre Islamabad, College of Physicians and Surgeons Pakistan. About 204 postgraduate medical trainee were enrolled in the study after taking written consent. All of the participants were working as a postgraduate medical trainee in different hospitals of Rawalpindi and Islamabad...
February 8, 2018: Curēus
Salman Tahir Shafi, Mohammad Saleem, Roshina Anjum, Wajid Abdullah, Tahir Shafi
In Pakistan, patients with chronic kidney disease (CKD) are commonly diagnosed at a late stage. There is little information about the refusal of hemodialysis by hospitalized CKD patients who need hemodialysis (HD) and reasons for acceptance and refusal among these patients. All patients with Stage V CKD who had medical indications to undergo HD and were hospitalized at a tertiary care facility over a six-month period were invited to participate in this study. Patients were surveyed regarding acceptance or refusing of HD and reasons for their decisions...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
Bruce A Berkowitz, Robert H Podolsky, Ali M Berri, Kristin Dernay, Emma Graffice, Fatema Shafie-Khorassani, Robin Roberts
Purpose: In cyclic light-reared Pde6brd10 mice, rod cell oxidative stress contributes to the degenerative phenotype. Dark rearing Pde6brd10 mice slows but does not prevent atrophy. This suggests that outer retinal oxidative stress occurs in Pde6brd10 mice independent of light exposure, a hypothesis tested in this study. Methods: Mouse strains Pde6brd10 and C57Bl/6 (wild type) were dark reared until postnatal day (P) 23 (P23) or P30. In subgroups of dark-reared mice, (1) layer-specific excessive free radical production (i...
March 1, 2018: Investigative Ophthalmology & Visual Science
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