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https://www.readbyqxmd.com/read/28430697/abusive-head-trauma-and-mortality-an-analysis-from-an-international-comparative-effectiveness-study-of-children-with-severe-traumatic-brain-injury
#1
Nikki Miller Ferguson, Ajit Sarnaik, Darryl Miles, Nadeem Shafi, Mark J Peters, Edward Truemper, Monica S Vavilala, Michael J Bell, Stephen R Wisniewski, James F Luther, Adam L Hartman, Patrick M Kochanek
OBJECTIVES: Small series have suggested that outcomes after abusive head trauma are less favorable than after other injury mechanisms. We sought to determine the impact of abusive head trauma on mortality and identify factors that differentiate children with abusive head trauma from those with traumatic brain injury from other mechanisms. DESIGN: First 200 subjects from the Approaches and Decisions in Acute Pediatric Traumatic Brain Injury Trial-a comparative effectiveness study using an observational, cohort study design...
April 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28421638/renal-replacement-therapy-and-incremental-hemodialysis-for-veterans-with-advanced-chronic-kidney-disease
#2
Kamyar Kalantar-Zadeh, Susan T Crowley, Srinivasan Beddhu, Joline L T Chen, John T Daugirdas, David S Goldfarb, Anna Jin, Csaba P Kovesdy, David J Leehey, Hamid Moradi, Sankar D Navaneethan, Keith C Norris, Yoshitsugu Obi, Ann O'Hare, Tariq Shafi, Elani Streja, Mark L Unruh, Tushar J Vachharajani, Steven Weisbord, Connie M Rhee
Each year approximately 13,000 Veterans transition to maintenance dialysis, mostly in the traditional form of thrice-weekly hemodialysis from the start. Among >6000 dialysis units nationwide, there are currently approximately 70 Veterans Affairs (VA) dialysis centers. Given this number of VA dialysis centers and their limited capacity, only 10% of all incident dialysis Veterans initiate treatment in a VA center. Evidence suggests that, among Veterans, the receipt of care within the VA system is associated with favorable outcomes, potentially because of the enhanced access to healthcare resources...
April 18, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28418007/saturated-fatty-acids-induce-development-of-both-metabolic-syndrome-and-osteoarthritis-in-rats
#3
Sunderajhan Sekar, Siti Raihanah Shafie, Indira Prasadam, Ross Crawford, Sunil K Panchal, Lindsay Brown, Yin Xiao
The predominant saturated fatty acids (SFA) in human diets are lauric acid (LA, C12:0), myristic acid (MA, C14:0), palmitic acid (PA, C16:0) and stearic acid (SA, C18:0). The aim of this study was to investigate whether diets containing individual SFA together with excess simple carbohydrates induce osteoarthritis (OA)-like changes in knee joints and signs of metabolic syndrome in rats. Rats were given either a corn starch diet or a diet composed of simple carbohydrates together with 20% LA, MA, PA, SA or beef tallow for 16 weeks...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28410828/early-onset-symptomatic-neuropathy-in-a-child-with-type-1-diabetes-mellitus
#4
Obeid Mohammad Shafi, Muzamil Latief
Diabetic neuropathy (DN) is a major complication of Type 1 Diabetes Mellitus (T1DM). It is usually subclinical in childhood, but can cause significant impairment with its progression through to adulthood. Current guidelines vary in their recommendation regarding screening for DN in children with T1DM, with some advocating starting screening 5 years after the diagnosis of T1DM. Clinical assessment comprising of history and neurological examination is the most commonly used method for screening, though Nerve Conduction Studies (NCS) provide better sensitivity in picking up early subclinical diabetic neuropathy...
April 5, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28409023/a-new-sutureless-illuminated-macular-buckle-designed-for-myopic-macular-hole-retinal-detachment
#5
Ahmed M Bedda, Ahmed M Abdel Hadi, Mohamed Lolah, Muhammad S Abd Al Shafy
Purpose. To report the anatomic and visual results of a new sutureless illuminated macular buckle designed for patients with macular hole retinal detachment related to high myopia (MMHRD). Design. Prospective nonrandomized comparative interventional trial. Methods. Twenty myopic eyes of 20 patients (mean age, 51.4 years; range, 35-65 years) presenting with MMHRD with a posterior staphyloma, in whom the new buckle was used, were evaluated. The buckle used was assembled from a 5 mm wide sponge and a 7 mm wide silicone tire; it was fixed utilizing the sterile topical adhesive Histoacryl Blue (B Braun, TS1050044FP) which polymerizes in seconds upon being exposed to water-containing substances...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28406780/dysphagia-an-unusual-presentation-of-metastatic-uterine-cervical-carcinoma
#6
Anam Hameed, Alexander A Dekovich, Phillip J Lum, Mehnaz A Shafi
Worldwide, cervical cancer is the third most common cancer among women and the fourth leading cause of death from cancer. The most common sites of metastasis are the pelvic lymph nodes, vagina, and the pelvic sidewalls. Distant metastases are uncommon but can involve the bone, lung, and liver. Characteristics associated with increased rate of distant metastasis include bulky tumor, endometrial extension, lymph node involvement, and advanced disease. We report the case of a woman with stage II cervical carcinoma, who presented with dysphagia due to cervical cancer metastases to the mediastinum...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28380488/hodgkin-lymphoma-outcome-a-retrospective-study-from-3-tertiary-centers-in-saudi-arabia
#7
Ruaa G Shafi, Mubarak M Al-Mansour, Solaf S Kanfar, Hani Al Hashmi, Ahmed Alsaeed, Meteb Al-Foheidi, Ezzeldin M Ibrahim
No abstract text is available yet for this article.
April 5, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28377317/dehydroascorbate-derivatized-chitosan-particles-for-targeting-antimalarial-agents-to-infected-erythrocytes
#8
Hasham Shafi, D V Siva Reddy, Tabassum Khan, Rajeev Ranjan, Ashish Srivastava, Suniti Vaishya, Tanuj Sharma, Mohammad Imran Siddiqui, Saman Habib, Amit Misra
The mammalian glucose transporter GLUT-1 and Plasmodium falciparum hexose transporter PfHT1 are overexpressed on human RBC infected with the parasite (iRBC), presumably for enhanced glucose uptake. Dehydroascorbic acid (DHA) competes out glucose in GLUT-1 binding. We prepared particles containing chloroquine phosphate using novel derivatives of chitosan (CSN). CSN was either pre-derivatized with DHA (PRE) or particles made of CSN were derivatized by surface-grafting DHA (POST). The optimized formulations were analyzed for size (170-200nm) drug content (about 40%) entrapment efficiency (50-57%), in vitro drug release (80% in 72h, Higuchi's model), hemolysis on exposure to whole blood or RBC at 5% hematocrit, cytotoxicity towards cultured HEK 293T (kidney) and HepG2 (hepatic) cells, targeting iRBC and in vitro efficacy against P...
April 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28375092/evaluation-of-acute-toxicity-sedative-and-analgesic-effects-of-taverniera-glabra-methanolic-extract-on-mice
#9
- Marvi, Javeid Iqbal, Shafi Muhammad, Mansoor Ahmad
Present study was conducted on crude methanolic extract of stem and root of Taverniera glabra. In Pakistan T. glabra is found in the region of Balochistan only. T. glabra has numerous therapeutic uses in traditional medicine and it is also used for the pain relief. Current study was carried out to evaluate acute toxicity, analgesic and CNS depressant activity of the plant. Acute toxicity was carried out by oral administration of the T. glabra extract from 250 to 2000mg/kg oral dose. Analgesic activity was carried out by acetic acid induced writhing test and formalin test...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28370991/polyethylene-versus-cotton-caps-as-adjunct-to-body-wrap-in-preterm-infants
#10
Shafie Hashim, Syed Zulkifli Syed Zakaria, Adli Ali, Shareena Ishak, Jaafar Rohana
BACKGROUND: Occlusive body wrap using polyethylene plastic applied immediately after birth had been shown to reduce hypothermia among preterm infants. Various adjunct methods have been studied in an attempt to further reduce the incidence of hypothermia. This study was conducted to determine whether polyethylene cap is more effective than cotton cap as an adjunct to polyethylene occlusive body wrap in reducing hypothermia among preterm infants. METHODS: Study subjects were preterm infants of 24 to 34 weeks gestation born at Universiti Kebangsaan Malaysia Medical Centre (UKMMC)...
March 29, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28367165/frequency-of-hepatitis-c-in-hospitalized-patients-with-chronic-kidney-disease
#11
Salman Tahir Shafi, Muhammad Zaigham Hassan, Mohammed Saleem, Roshina Anjum, Wajid Abdullah, Tahir Shafi
BACKGROUND AND OBJECTIVES: Hepatitis C and chronic kidney disease (CKD) are major global health problems and are highly prevalent in Pakistan. There is limited information on prevalence of hepatitis C in patients with CKD not yet on dialysis. The objective of this study was to determine the frequency of hepatitis C in hospitalized chronic kidney disease patients at a tertiary care center in Pakistan. METHODS: The study design was cross-sectional in nature. Patients between ages of 20-80 years with CKD not previously on renal replacement therapy and who were admitted to nephrology ward at a tertiary care facility were included...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28366517/risks-of-adverse-events-in-advanced-ckd-the-chronic-renal-insufficiency-cohort-cric-study
#12
Morgan E Grams, Wei Yang, Casey M Rebholz, Xue Wang, Anna C Porter, Lesley A Inker, Edward Horwitz, James H Sondheimer, L Lee Hamm, Jiang He, Matthew R Weir, Bernard G Jaar, Tariq Shafi, Lawrence J Appel, Chi-Yuan Hsu
BACKGROUND: People with advanced chronic kidney disease are at risk for the development of end-stage renal disease (ESRD), but also many other adverse outcomes, including cardiovascular disease (CVD) events and death. Determination of risk factors that explain the variability in prognosis and timing of these adverse outcomes can aid patient counseling and medical decision making. STUDY DESIGN: Prospective research cohort. SETTING & PARTICIPANTS: 1,798 participants with estimated glomerular filtration rates (eGFRs)<30mL/min/1...
March 30, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28360391/complement-component-3-characterization-and-association-with-mastitis-resistance-in-egyptian-water-buffalo-and-cattle
#13
Nermin El-Halawany, Shawky A Abd-El-Monsif, F M Al-Tohamy Ahmed, Lamees Hegazy, Hamdy Abdel-Shafy, Magdy A Abdel-Latif, Yasser A Ghazi, Christiane Neuhoff, Dessie Salilew-Wondim, Karl Schellander
Mastitis is an infectious disease of the mammary gland that leads to reduced milk production and change in milk composition. Complement component C3 plays a major role as a central molecule of the complement cascade involving in killing of microorganisms, either directly or in cooperation with phagocytic cells. C3 cDNA were isolated, from Egyptian buffalo and cattle, sequenced and characterized. The C3 cDNA sequences of buffalo and cattle consist of 5025 and 5019 bp, respectively. Buffalo and cattle C3 cDNAs share 99% of sequence identity with each other...
March 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28353110/heavy-metal-monitoring-analysis-and-prediction-in-lakes-and-rivers-state-of-the-art
#14
Adnan Elzwayie, Haitham Abdulmohsin Afan, Mohammed Falah Allawi, Ahmed El-Shafie
Several research efforts have been conducted to monitor and analyze the impact of environmental factors on the heavy metal concentrations and physicochemical properties of water bodies (lakes and rivers) in different countries worldwide. This article provides a general overview of the previous works that have been completed in monitoring and analyzing heavy metals. The intention of this review is to introduce the historical studies to distinguish and understand the previous challenges faced by researchers in analyzing heavy metal accumulation...
March 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28349108/power-analysis-dataset-for-qca-based-multiplexer-circuits
#15
Md Abdullah-Al-Shafi, Ali Newaz Bahar, Peer Zahoor Ahmad, Firdous Ahmad, Mohammad Maksudur Rahman Bhuiyan, Kawsar Ahmed
Power consumption in irreversible QCA logic circuits is a vital and a major issue; however in the practical cases, this focus is mostly omitted.The complete power depletion dataset of different QCA multiplexers have been worked out in this paper. At -271.15 °C temperature, the depletion is evaluated under three separate tunneling energy levels. All the circuits are designed with QCADesigner, a broadly used simulation engine and QCAPro tool has been applied for estimating the power dissipation.
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28341348/the-impact-of-oral-polypodium-leucotomos-extract-on-ultraviolet-b-response-a-human-clinical-study
#16
Indermeet Kohli, Rubina Shafi, Prescilia Isedeh, James L Griffith, Mohammed S Al-Jamal, Narumol Silpa-Archa, Bradford Jackson, Mohammed Athar, Nikiforos Kollias, Craig A Elmets, Henry W Lim, Iltefat H Hamzavi
BACKGROUND: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. OBJECTIVE: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE). METHODS: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser)...
March 21, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28334228/a-survey-of-the-approaches-for-identifying-differential-methylation-using-bisulfite-sequencing-data
#17
Adib Shafi, Cristina Mitrea, Tin Nguyen, Sorin Draghici
DNA methylation is an important epigenetic mechanism that plays a crucial role in cellular regulatory systems. Recent advancements in sequencing technologies now enable us to generate high-throughput methylation data and to measure methylation up to single-base resolution. This wealth of data does not come without challenges, and one of the key challenges in DNA methylation studies is to identify the significant differences in the methylation levels of the base pairs across distinct biological conditions. Several computational methods have been developed to identify differential methylation using bisulfite sequencing data; however, there is no clear consensus among existing approaches...
March 8, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28320363/the-mediational-role-of-physical-activity-social-contact-and-stroke-on-the-association-between-age-education-employment-and-dementia-in-an-asian-older-adult-population
#18
Edimansyah Abdin, Siow Ann Chong, Chao Xu Peh, Janhavi Ajit Vaingankar, Boon Yiang Chua, Swapna Verma, Anitha Jeyagurunathan, Saleha Shafie, Mythily Subramaniam
BACKGROUND: Our study aimed to investigate the pathways by which socio-demographic factors, modifiable health and lifestyle risk factors influence each other, and subsequently, lead to dementia. METHODS: We used data from the Well-being of the Singapore Elderly study, a nationally representative survey of the older adult population aged 60 years and above in Singapore. Dementia diagnosis was established using 10/66 dementia criteria. Structural equation modelling (SEM) without latent variable was applied to confirm the hypothesized model...
March 20, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28320346/process-for-developing-rehabilitation-practice-recommendations-for-individuals-with-traumatic-brain-injury
#19
Librada Callender, Rachel Brown, Simon Driver, Marie Dahdah, Ashley Collinsworth, Shahid Shafi
BACKGROUND: Attempts at measuring quality of rehabilitation care are hampered by a gap in knowledge translation of evidence-based approaches and lack of consensus on best practices. However, adoption of evidence-based best practices is needed to minimize variations and improve quality of care. Therefore, the objective of this project was to describe a process for assessing the quality of evidence of clinical practices in traumatic brain injury (TBI) rehabilitative care. METHODS: A multidisciplinary team of clinicians developed discipline-specific clinical questions using the Population, Intervention, Control, Outcome process...
March 20, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28317625/relationship-among-pulmonary-hypertension-autoimmunity-thyroid-hormones-and-dyspnea-in-patients-with-hyperthyroidism
#20
Sayid Shafi Zuhur, Derya Baykiz, Sonat Pinar Kara, Ertan Sahin, Idris Kuzu, Gulsah Elbuken
OBJECTIVE: Previous studies have reported conflicting results regarding the mechanisms underlying the pathophysiology of pulmonary hypertension (PHT) in patients with hyperthyroidism. Therefore, in this study, we investigated the association between PHT and thyroid-stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody, thyroglobulin antibody, TSH, fT3, fT4 and dyspnea during daily activities in a large population of patients with hyperthyroidism. METHODS: A total of 129 consecutive patients with hyperthyroidism, 37 with hypothyroidism and 38 euthyroid controls were enrolled in this study...
April 2017: American Journal of the Medical Sciences
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