Xiangyan Chen, Qiong Xia, Ningwei Sun, Hailei Zhou, Zhihao Xu, Xi Yang, Ran Yan, Ping Li, Tingting Li, Xiang Qin, Hong Yang, Chunhui Wu, Fengming You, Xiaoling Liao, Shun Li, Yiyao Liu
Circulating tumor cells (CTCs) acquire enhanced anti-anoikis abilities after experiencing flow shear stress in the circulatory system. Our previous study demonstrated that low shear stress (LSS) promotes anoikis resistance of human breast carcinoma cells via caveolin-1 (Cav-1)-dependent extrinsic and intrinsic apoptotic pathways. However, the underlying mechanism how LSS enhanced Cav-1 expression in suspended cancer cells remains unclear. Herein, we found that LSS induced redox signaling was involved in the regulation of Cav-1 level and anoikis resistance in suspension cultured cancer cells...
October 12, 2022: Free Radical Biology & Medicine