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https://www.readbyqxmd.com/read/29784554/renal-stress-and-kidney-injury-biomarkers-in-response-to-endurance-cycling-in-the-heat-with-and-without-ibuprofen
#1
Brendon P McDermott, Cody R Smith, Cory L Butts, Aaron R Caldwell, Elaine C Lee, Jakob L Vingren, Colleen X Munoz, Laura J Kunces, Keith Williamson, Matthew S Ganio, Lawrence E Armstrong
Exercise, especially in the heat, can contribute to acute kidney injury, which can expedite chronic kidney disease onset. The additional stress of ibuprofen use is hypothesized to increase renal stress. OBJECTIVES: To observe the effects of endurance cycling in the heat on renal function. Secondarily, we investigated the effect of ibuprofen ingestion on kidney stress. DESIGN: Randomized, placebo controlled and observational methods were utilized. METHODS: Forty cyclists (52±9y, 21...
May 16, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29784025/prevalence-of-electrolyte-disturbances-in-perinatal-asphyxia-a-prospective-study
#2
Jitendra Thakur, Nisha Keshary Bhatta, Rupa Rajbhandari Singh, Prakash Poudel, Madhab Lamsal, Anjum Shakya
BACKGROUND: Birth asphyxia is defined as the presence of hypoxia, hypercapnia, and acidosis leading the newborn to systemic disturbances probably electrolyte disturbance also. Knowledge of these electrolyte disturbances is very valuable as it can be an important parameter affecting perinatal morbidity, mortality and ongoing management. METHODS: Serum sodium, potassium and ionized calcium of asphyxiated term newborn were sent within one hour of birth as per the inclusion criteria...
May 21, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29782992/single-ultra-high-dose-cholecalciferol-to-prevent-vitamin-d-deficiency-in-pediatric-hematopoietic-stem-cell-transplantation
#3
Gregory Wallace, Sonata Jodele, Kasiani C Myers, Christopher E Dandoy, Javier El-Bietar, Adam Nelson, Ashley Teusink-Cross, Pooja Khandelwal, Cynthia Taggart, Catherine M Gordon, Stella M Davies, Jonathan C Howell
BACKGROUND: Vitamin D (vitD) deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior transplant survival at 100 days after transplantation. Achieving and maintaining therapeutic vitD levels in HSCT recipients is extremely challenging in the first 3-6 months after transplant due to poor compliance in the setting of mucositis, and concomitant use of critical transplant drugs that interfere with vitD absorption. We sought to evaluate the safety and efficacy of a single, ultra-high dose of vitD given prior to childhood HSCT to maintain levels in a therapeutic range during the peri-transplantation period...
May 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29772226/potential-role-of-peroxisome-proliferator-activated-receptor-gamma-activation-on-serum-visfatin-and-trace-elements-in-high-fat-diet-induced-type-2-diabetes-mellitus
#4
Arshia Tabassum, Syeda Nuzhat Fatima Zaidi, Kausar Yasmeen, Tabassum Mahboob
AIMS: Electrolytes and trace elements dysregulation play an important role in the progression of obesity and diabetes complications. The present study was designed to evaluate the insulin sensitizing effects of peroxisomes proliferators activated receptor gamma (PPAR-γ) agonist on trace elements in obesity induced type 2 diabetes mellitus and correlate with serum visfatin. MATERIALS AND METHODS: Wistar rats were categorized into five groups. Group I served as control; Group II fed on high fat diet (HFD); Group III fed on HFD and treated with rosiglitazone (3 mg/kg) for 7 days; Group IV were T2DM rats induce by HFD and low dose of streptozotocin (i...
May 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29771807/administration-of-an-oral-hydration-solution-prevents-electrolyte-and-fluid-disturbances-and-reduces-readmissions-in-patients-with-a-diverting-ileostomy-after-colorectal-surgery-a-prospective-randomized-controlled-trial
#5
Athanasios Migdanis, Georgios Koukoulis, Ioannis Mamaloudis, Ioannis Baloyiannis, Ioannis Migdanis, Maria Kanaki, Eleni Malissiova, Georgios Tzovaras
BACKGROUND: Patients with a newly formed ileostomy often develop electrolyte abnormalities and dehydration. OBJECTIVE: The study assessed the prophylactic effect of an isotonic hydration solution on dehydration and electrolyte abnormalities in patients with a newly formed ileostomy. DESIGN: This was a prospective, randomized, controlled trial (NCT02036346). SETTINGS: The study was conducted at a single surgical unit of a public university hospital...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29770976/pharmacokinetic-and-pharmacodynamic-properties-of-orally-administered-torsemide-in-healthy-horses
#6
Gustavo F Agne, Seung Woo Jung, Anne A Wooldridge, Susan H Duran, William Ravis, Ramiro Toribio
BACKGROUND: Diuretic treatment is the mainstay for management of congestive heart failure in horses, and its use has been restricted to injectable medications because no currently data supports the use of PO administered loop diuretics. OBJECTIVES: To determine the pharmacokinetic and pharmacodynamic properties of PO administered torsemide and, determine if PO administered torsemide, could be used as an alternative to injectable diuretics in the horse. ANIMALS: Six healthy adult mares...
May 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29767557/polycystin-1-dysfunction-impairs-electrolyte-and-water-handling-in-a-renal-pre-cystic-mouse-model-for-adpkd
#7
Eric H J Verschuren, Sami G Mohammed, Wouter N Leonhard, Caro Overmars-Bos, Kimberly A M Veraar, Joost G J Hoenderop, René J M Bindels, Dorien J M Peters, Francisco J Arjona
The PKD1 gene encodes polycystin-1 (PC1), a mechanosensor triggering intracellular responses upon urinary flow sensing in kidney tubular cells. Mutations in PKD1 lead to autosomal dominant polycystic kidney disease (ADPKD). The involvement of PC1 in renal electrolyte handling remains unknown since renal electrolyte physiology in ADPKD patients has only been characterized in cystic ADPKD. We thus studied the renal electrolyte handling in inducible kidney-specific Pkd1 knockout (iKsp-Pkd1-/-) mice manifesting a pre-cystic phenotype...
May 16, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29757121/management-of-electrolyte-disorders-also-the-method-matters
#8
Joris Richard Delanghe
INTRODUCTION: For the last few decades, electrolyte determinations in plasma or serum are carried out by reliable potentiometric methods. In recent years, a marked technical evolution has taken place, where the clinical analysis of common analytes (e.g. electrolytes) is partly moving from centralised clinical core laboratories to near-patient point-of-care testing. METHODS: As the measuring principle used by point-of-care testing markedly differs from the one used in core laboratories, sodium results are not always interchangeable in critically ill patients due to the different sensitivity of the analytical methods for the electrolyte exclusion effect...
May 14, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29751506/neurocognitive-disorders-and-dehydration-in-older-patients-clinical-experience-supports-the-hydromolecular-hypothesis-of-dementia
#9
Michele Lauriola, Antonio Mangiacotti, Grazia D'Onofrio, Leandro Cascavilla, Francesco Paris, Giulia Paroni, Davide Seripa, Antonio Greco, Daniele Sancarlo
Abnormalities of water homeostasis can be early expressions of neuronal dysfunction, brain atrophy, chronic cerebrovasculopathy and neurodegenerative disease. The aim of this study was to analyze the serum osmolality of subjects with cognitive impairment. One thousand and ninety-one consecutive patients attending the Alzheimer’s Evaluation Unit were evaluated with the Mini-Mental State Examination (MMSE), 21-Item Hamilton Depression Rating Scale (HDRS-21), Activities of Daily Living (ADL), Instrumental-ADL (IADL), Mini Nutritional Assessment (MNA), Exton-Smith Scale (ESS), and Cumulative Illness Rating Scale (CIRS)...
May 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29743097/changes-in-energy-metabolism-and-levels-of-stress-related-hormones-and-electrolytes-in-horses-after-intravenous-administration-of-romifidine-and-the-peripheral-%C3%AE-2-adrenoceptor-antagonist-vatinoxan
#10
Soile Anja Eliisa Pakkanen, Annemarie de Vries, Marja Riitta Raekallio, Anna Kristina Mykkänen, Mari Johanna Palviainen, Satu Marja Sankari, Outi Maritta Vainio
BACKGROUND: Romifidine, an α-2 adrenoceptor agonist, is a widely-used sedative in equine medicine. Besides the desired sedative and analgesic actions, α-2 adrenoceptor agonists have side effects like alterations of plasma concentrations of glucose and certain stress-related hormones and metabolites in various species. Vatinoxan (previously known as MK-467), in turn, is an antagonist of α-2 adrenoceptors. Because vatinoxan does not cross the blood brain barrier in significant amounts, it has only minor effect on sedation induced by α-2 adrenoceptor agonists...
May 9, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29731714/proton-pump-inhibitors-and-serum-magnesium-levels-in-patients-with-torsades-de-pointes
#11
Pietro E Lazzerini, Iacopo Bertolozzi, Francesco Finizola, Maurizio Acampa, Mariarita Natale, Francesca Vanni, Rosella Fulceri, Alessandra Gamberucci, Marco Rossi, Beatrice Giabbani, Michele Caselli, Ilaria Lamberti, Gabriele Cevenini, Franco Laghi-Pasini, Pier L Capecchi
Background: Torsades de pointes (TdP) is a life-threatening ventricular tachycardia occurring in long QT-syndrome patients. It usually develops when multiple QT-prolonging factors are concomitantly present, more frequently drugs and electrolyte imbalances. Since proton-pump inhibitors (PPIs)-associated hypomagnesemia is an increasingly recognized adverse event, PPIs were recently included in the list of drugs with conditional risk of TdP, despite only few cases of TdP in PPI users have been reported so far...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29731287/controversies-in-management-of-hyperkalemia
#12
Brit Long, Justin R Warix, Alex Koyfman
BACKGROUND: Hyperkalemia is a common electrolyte disorder that can result in morbidity and mortality if not managed appropriately. OBJECTIVES: This review evaluates the classic treatments of hyperkalemia and discusses controversies and new medications for management. DISCUSSION: Potassium (K+) plays a key role in determining the transmembrane potentials of "excitable membranes" present in nerve and muscle cells. K+ is the predominant intracellular cation, and clinical deterioration typically ensues when patients develop sufficiently marked elevation in extracellular fluid concentrations of K+ (hyperkalemia)...
May 3, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29730103/value-of-routine-preoperative-tests-for-coagulation-before-elective-cranial-surgery-results-of-an-institutional-audit-and-a-nationwide-survey-of-neurosurgical-centers-in-pakistan
#13
Naveed Zaman Akhunzada, Muhammad Bilal Tariq, Saad Akhtar Khan, Sidra Sattar, Wajeeha Tariq, Muhammad Shahzad Shamim, Samie Asghar Dogar
Routine preoperative blood testing has become a dogma. The general practice is to order preoperative work up as a knee jerk response rather than individualize it for each patient. The fact that the bleeding brain tends to swell, which coupled with limited options for proximal control, packing and overall hemostasis, leads to an over emphasis on preoperative coagulation profile. MATERIAL AND METHODS: This is a retrospective review of the medical records of patients admitted at Aga Khan University Hospital from January 2010 to December 2015 for an elective craniotomy...
May 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29728048/impact-of-bioactive-peptide-motifs-on-molecular-structure-charging-and-non-fouling-properties-of-poly-ethylene-oxide-brushes
#14
Ognen Pop-Georgievski, Ralf Zimmermann, Ilya Kotelnikov, Vladimir Proks, Dirk Romeis, Jan Kucka, Anja Caspari, Frantisek Rypacek, Carsten Werner
Polymer layers capable of suppressing protein adsorption from biological media while presenting extracellular matrix derived peptide motifs offer valuable new options for biomimetic surface engineering. Herein, we provide detailed insights into physico-chemical changes induced in a non-fouling poly(ethylene oxide) (PEO) brush/polydopamine (PDA) system by incorporation of adhesion ligand (RGD) peptides. Brushes with high surface chain densities (σ ≥ 0.5 chains·nm-2 ) and pronounced hydrophilicity (water contact angles ≤ 10°) were prepared by end-tethering of hetero-bifunctional PEOs (Mn ~ 20000 g∙mol-1 ) to PDA-modified surfaces from a reactive melt...
May 4, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29727526/incidence-of-hypochloremic-metabolic-alkalosis-in-dogs-and-cats-with-and-without-nasogastric-tubes-over-a-period-of-up-to-36-hours-in-the-intensive-care-unit
#15
Annie Chih, Elke Rudloff, Cheryl Waldner, Andrew K J Linklater
OBJECTIVE: To evaluate the incidence of hypochloremic metabolic alkalosis (HCMA) in dogs and cats in the ICU that had intermittent nasogastric tube (NGT) aspiration for up to 36 hours. DESIGN: Prospective cohort study (December 2013 to October 2014). SETTING: Privately owned emergency and referral teaching hospital. ANIMALS: Forty-nine client-owned dogs and 16 client-owned cats. INTERVENTIONS: Patients wherein NGT placement was recommended and client consent was obtained were included in the interventional group...
May 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29707882/dietitians-opinions-regarding-refeeding-syndrome-clinical-guidelines-and-extended-scope-of-practice
#16
Kylie L Matthews, Michelle A Palmer, Sandra M Capra
AIM: Refeeding syndrome (RFS) prevalence rates vary across studies depending on the criteria used for assessment and identification. For registered dietitians, the assessment and management of RFS is highly reliant on daily serum electrolyte values; however, registered dietitians working within Australia do not currently possess laboratory test ordering privileges. We aimed to examine the opinions of registered dietitians regarding RFS identification, management and guidelines and the option of using extended scope of practice to order electrolyte monitoring autonomously...
April 30, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29703048/tolvaptan-rescue-contrast-induced-acute-kidney-injury-a-case-report
#17
Wei-Chieh Lee, Hsiu-Yu Fang, Chih-Yuan Fang
RATIONALE: Contrast-induced acute kidney injury is one of the most serious adverse effects of contrast media and is related to three distinct but interacting mechanisms: medullary ischemia, formation of reactive oxygen species and direct tubular cell toxicity, especially in the patients with chronic kidney disease. The strategies of treatment, including stabilization of hemodynamic parameters and maintenance of normal fluid and electrolyte balance, were similar to the management of other types of acute kidney injury...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29700220/intensive-care-management-of-severe-hypernatraemia-in-the-context-of-group-a-streptococcal-septicaemia
#18
Bethan Davies, Robert Jesty, Shahana Uddin, Victoria Metaxa
This case describes a 54-year-old woman with exudative eczema, who was admitted to the intensive care unit with a serum sodium concentration of 191 mmol/L, secondary to profound dehydration in the context of group A streptococcal septicaemia. Successful rehydration and electrolyte normalisation was achieved with continuous venovenous haemodiafiltration (CVVHDF), the replacement fluid of which was infused with hypertonic saline to limit the rate of sodium reduction. This case report comments on three areas of interest...
April 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29698719/serum-chloride-levels-track-with-survival-in-patients-with-pulmonary-arterial-hypertension
#19
Tawfeq Naal, Batool Abuhalimeh, Ghaleb Khirfan, Raed A Dweik, W H Wilson Tang, Adriano R Tonelli
BACKGROUND: Serum chloride is an important homeostatic biomarker in left heart failure, with significant prognostic implications. The impact of serum chloride in the long-term survival of pulmonary arterial hypertension (PAH) patients is unknown. We tested whether serum chloride levels are associated with long-term survival in PAH patients. METHODS: We included patients with idiopathic or heritable PAH who had a basic metabolic panel performed at the time of their diagnostic right heart catheterization...
April 23, 2018: Chest
https://www.readbyqxmd.com/read/29681164/effect-of-diet-with-carbohydrate-but-without-daily-energy-restriction-on-serum-glucose-lactate-and-selected-mineral-and-lipid-levels-in-streptozotocin-induced-experimental-diabetic-rats
#20
Osman Sinan Ozsezen, Ismail Meral
OBJECTIVE: Type I diabetes is a disease characterised by an extreme reduction in serum insulin levels. Diet and exercise have gained considerable attention in the treatment of diabetes. Therefore, this study was carried out to investigate the effect of diet with carbohydrate but without daily energy restriction on various metabolites (glucose, triglycerides, cholesterol, lactate), some electrolytes (Ca, Mg, Na, K, P, Cl) and essential metals (Mn, Co, Cu, Se, Zn, Fe) in the blood of rats with streptozotocin-induced diabetes...
April 21, 2018: Archives of Physiology and Biochemistry
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