Alexia G Cosby, Trevor Arino, Tyler A Bailey, Matthew Buerger, Joshua J Woods, Luis M Aguirre Quintana, Jennifer V Alvarenga Vasquez, Jennifer N Wacker, Alyssa N Gaiser, Roland K Strong, Rebecca J Abergel
The mammalian protein siderocalin binds bacterial siderophores and their iron complexes through cation-π and electrostatic interactions, but also displays high affinity for hydroxypyridinone complexes of trivalent lanthanides and actinides. In order to circumvent synthetic challenges, the use of siderocalin-antibody fusion proteins is explored herein as an alternative targeting approach for precision delivery of trivalent radiometals. We demonstrate the viability of this approach in vivo , using the theranostic pair 90 Y (β- , t 1/2 = 64 h)/86 Y (β+ , t 1/2 = 14...
August 3, 2023: RSC chemical biology