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https://www.readbyqxmd.com/read/28197686/pre-therapeutic-factors-for-predicting-survival-after-radioembolization-a-single-center-experience-in-389-patients
#1
K J Paprottka, F Schoeppe, M Ingrisch, J Rübenthaler, N N Sommer, E De Toni, H Ilhan, M Zacherl, A Todica, P M Paprottka
PURPOSE: To determine pre-therapeutic predictive factors for overall survival (OS) after yttrium (Y)-90 radioembolization (RE). METHODS: We retrospectively analyzed the pre-therapeutic characteristics (sex, age, tumor entity, hepatic tumor burden, extrahepatic disease [EHD] and liver function [with focus on bilirubin and cholinesterase level]) of 389 consecutive patients with various refractory liver-dominant tumors (hepatocellular carcinoma [HCC], cholangiocarcinoma [CCC], neuroendocrine tumor [NET], colorectal cancer [CRC] and metastatic breast cancer [MBC]), who received Y-90 radioembolization for predicting survival...
February 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28078375/assessing-intra-arterial-complications-of-planning-and-treatment-angiograms-for-y-90-radioembolization
#2
Osman Ahmed, Mikin V Patel, Abdulrahman Masrani, Bradford Chong, Mohammed Osman, Jordan Tasse, Jayesh Soni, Ulku Cenk Turba, Bulent Arslan
PURPOSE: To report hepatic arterial-related complications encountered during planning and treatment angiograms for radioembolization and understand any potential-associated risk factors. MATERIALS AND METHODS: 518 mapping or treatment angiograms for 180 patients with primary or metastatic disease to the liver treated by Yttrium-90 radioembolization between 2/2010 and 12/2015 were retrospectively reviewed. Intra-procedural complications were recorded per SIR guidelines...
January 11, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28048122/su-f-j-182-investigation-of-systems-for-improved-accuracy-in-clinical-y-90-percent-delivered-calculations
#3
R McBeth, D Elder, A Kesner
PURPOSE: Y-90 Selective Internal Radiation Therapy (SIRT) is used to treat liver tumors, and by nature has variability in the percent of the intended dose that is actually delivered. To determine the quality of the administration, pre and post activity measurements are taken, and used to infer percent delivered. Vendor specifications indicate the use of an ion chamber to take these measurements. In our work, we investigated the accuracy of ion chambers, and compared them to other detector systems...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047292/tu-fg-201-12-designing-a-risk-based-quality-assurance-program-for-a-newly-implemented-y-90-microspheres-procedure
#4
D Vile, L Zhang, L Cuttino, S Kim, J Palta
PURPOSE: To create a quality assurance program based upon a risk-based assessment of a newly implemented SirSpheres Y-90 procedure. METHODS: A process map was created for a newly implemented SirSpheres procedure at a community hospital. The process map documented each step of this collaborative procedure, as well as the roles and responsibilities of each member. From the process map, different potential failure modes were determined as well as any current controls in place...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046903/su-f-t-687-comparison-of-spect-ct-based-methodologies-for-estimating-lung-dose-from-y-90-radioembolization
#5
S Kost, S Lin, N Yu
PURPOSE: To compare mean lung dose (MLD) estimates from 99mTc macroaggregated albumin (MAA) SPECT/CT using two published methodologies for patients treated with (90) Y radioembolization for liver cancer. METHODS: MLD was estimated retrospectively using two methodologies for 40 patients from SPECT/CT images of 99mTc-MAA administered prior to radioembolization. In these two methods, lung shunt fractions (LSFs) were calculated as the ratio of scanned lung activity to the activity in the entire scan volume or to the sum of activity in the lung and liver respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27983951/trans-arterial-radioembolization-for-hepatocellular-carcinoma-who-when%C3%A2-and-y-90
#6
EDITORIAL
Neil Mehta, Francis Y Yao
No abstract text is available yet for this article.
October 27, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27875761/prognostic-value-of-post-yttrium-90-radioembolization-therapy-18f-fluorodeoxyglucose-positron-emission-tomography-in-patients-with-liver-tumors
#7
Sebastian Obrzut, Kevin McCammack, Karam W Badran, Anthony Balistreri, Evan Ou, Brian J Nguyen, Carl K Hoh, Steven C Rose
OBJECTIVE: This study assessed the benefit of post-therapy (18)F-FDG PET/CT versus CT alone in identifying malignant liver tumor progression following radioembolization with Y-90 microspheres. METHODS: 24 patients with 44 liver tumors underwent CT imaging pre-radioembolization and PET/CT post-radioembolization. Predictive value of Response Evaluation Criteria in Solid Tumors (RECIST 1.1), The World Health Organization (WHO), mRECIST and European Association for the Study of the Liver (EASL) with PET/CT versus CT alone was assessed...
November 16, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27806615/a-volume-equivalent-spherical-necrosis-tumor-normal-liver-model-for-estimating-absorbed-dose-in-yttrium-90-microsphere-therapy
#8
Chin-Hui Wu, Yi-Jen Liao, Tzung-Yi Lin, Yu-Cheng Chen, Shung-Shung Sun, Yen-Wan Hsueh Liu, Shih-Ming Hsu
PURPOSE: Primary hepatocellular carcinoma and metastatic liver tumors are highly malignant tumors in Asia. The incidence of fatal liver cancer is also increasing in the United States. The aim of this study was to establish a spherical tumor model and determine its accuracy in predicting the absorbed dose in yttrium-90 (Y-90) microsphere therapy for liver cancer. METHODS: Liver morphology can be approximated by a spherical model comprising three concentric regions representing necrotic, tumor, and normal liver tissues...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27782730/comparison-of-quantitative-y-90-spect-and-non-time-of-flight-pet-imaging-in-post-therapy-radioembolization-of-liver-cancer
#9
COMPARATIVE STUDY
Jianting Yue, Thibault Mauxion, Diane K Reyes, Martin A Lodge, Robert F Hobbs, Xing Rong, Yinfeng Dong, Joseph M Herman, Richard L Wahl, Jean-François H Geschwind, Eric C Frey
PURPOSE: Radioembolization with yttrium-90 microspheres may be optimized with patient-specific pretherapy treatment planning. Dose verification and validation of treatment planning methods require quantitative imaging of the post-therapy distribution of yttrium-90 (Y-90). Methods for quantitative imaging of Y-90 using both bremsstrahlung SPECT and PET have previously been described. The purpose of this study was to compare the two modalities quantitatively in humans. METHODS: Calibration correction factors for both quantitative Y-90 bremsstrahlung SPECT and a non-time-of-flight PET system without compensation for prompt coincidences were developed by imaging three phantoms...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27771496/phase-ii-study-of-yttrium-90-ibritumomab-tiuxetan-as-part-of-reduced-intensity-conditioning-with-melphalan-fludarabine-%C3%A2-thiotepa-for-allogeneic-transplantation-in-relapsed-or-refractory-aggressive-b-cell-lymphoma-a-geltamo-trial
#10
Monica Cabrero, Alejandro Martin, Javier Briones, Jorge Gayoso, Isidro Jarque, Javier López, Carlos Grande, Inmaculada Heras, Reyes Arranz, Teresa Bernal, Estefania Perez-Lopez, Oriana López-Godino, Eulogio Conde, Dolores Caballero
We designed a phase II clinical trial including Y-90 ibritumomab-tiuxetan as part of a reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (AlloSCT) in high-risk non-Hodgkin lymphoma (Clinical Trials Identifier: NCT00644371). Eligible patients had high-risk relapsed/refractory aggressive lymphoma. The conditioning regimen consisted of rituximab 250 mg (days -21 and -14), Y-90 ibritumomab IV (.4 m Ci/kg, day -14), fludarabine 30 mg/m(2) i.v. (days -3 and -2) plus melphalan 70 mg/m(2) i...
January 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27677906/y-90-ibritumomab-tiuxetan-y-90-it-and-high-dose-melphalan-as-conditioning-regimen-before-autologous-stem-cell-transplantation-for-elderly-patients-with-lymphoma-in-relapse-or-resistant-to-chemotherapy-a-feasibility-trial-sakk-37-05
#11
Michèle Voegeli, Stephanie Rondeau, Simona Berardi Vilei, Erika Lerch, Luciano Wannesson, Thomas Pabst, Jochen Rentschler, Mario Bargetzi, Lorenz Jost, Nicolas Ketterer, Angelika Bischof Delaloye, Michele Ghielmini
Standard conditioning regimens for autologous stem cell transplantation (ASCT) are often not tolerated by elderly patients, on one hand. Single high-dose melphalan, on the other hand, has been shown to be safe and active as a pretransplant preparative regimen in elderly patients. Y(90) -Ibritumomab tiuxetan (Y(90) -IT) is well tolerated and feasible in the transplantation setting. We therefore investigated the combination of high-dose melphalan and Y(90) -IT as a conditioning regimen for patients ≥65 years of age...
September 28, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27675254/clinical-significance-of-different-contouring-software-on-formalism-based-y-90-dose-prescriptions
#12
C Tien, R Yedavalli
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673890/impact-of-sarcopenia-evaluated-using-the-total-psoas-area-tpa-in-patient-undergoing-y-90-radioembolization-for-hepatocellular-carcinoma-hcc
#13
P Ioannides, Y A Abuodeh, W Jin, S E Hoffe, J M Frakes, R Kim, J Choi, G El-Hadda, B Biebel, B Kis, J Sweeney, M Friedman, N Kothari, D Anaya, K Latifi
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27618420/process-improvement-for-the-safe-delivery-of-multidisciplinary-executed-treatments-a-case-in-y-90-microspheres-therapy
#14
Bin Cai, Michael B Altman, Jose Garcia-Ramirez, Jason LaBrash, S Murty Goddu, Sasa Mutic, Parag J Parikh, Jeffrey R Olsen, Nael Saad, Jacqueline E Zoberi
PURPOSE: To develop a safe and robust workflow for yttrium-90 (Y-90) radioembolization procedures in a multidisciplinary team environment. METHODS AND MATERIALS: A generalized Define-Measure-Analyze-Improve-Control (DMAIC)-based approach to process improvement was applied to a Y-90 radioembolization workflow. In the first DMAIC cycle, events with the Y-90 workflow were defined and analyzed. To improve the workflow, a web-based interactive electronic white board (EWB) system was adopted as the central communication platform and information processing hub...
January 2017: Brachytherapy
https://www.readbyqxmd.com/read/27593256/preliminary-experience-with-yttrium-90-labelled-rituximab-chimeric-anti-cd-20-antibody-in-patients-with-relapsed-and-refractory-b-cell-non-hodgkins-lymphoma
#15
Parul Thakral, Suhas Singla, Atul Vashist, Madhav P Yadav, Santosh K Gupta, Jaya S Tyagi, Atul Sharma, Chandra S Bal, EmptyYN Y Snehlata, Arun Malhotra
BACKGROUND AND OBJECTIVES: The aim of the study is to evaluate the therapeutic efficacy and safety of Yttrium- 90 radiolabelled chimeric anti CD20 antibody-Rituximab in the treatment of patients with relapsed/ refractory B cell Non-Hodgkins Lymphoma (NHL). METHODS: Twenty patients with relapsed/refractory CD20+ NHL in progressive state were included in the study. These patients had undergone a median of 2 (range 2-5) prior standard chemotherapy ± immunotherapy regimens...
2016: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/27553471/renal-function-assessment-during-peptide-receptor-radionuclide-therapy
#16
REVIEW
Belkis Erbas, Murat Tuncel
Theranostics labeled with Y-90 or Lu-177 are highly efficient therapeutic approaches for the systemic treatment of various cancers including neuroendocrine tumors and prostate cancer. Peptide receptor radionuclide therapy (PRRT) has been used for many years for metastatic or inoperable neuroendocrine tumors. However, renal and hematopoietic toxicities are the major limitations for this therapeutic approach. Kidneys have been considered as the "critical organ" because of the predominant glomerular filtration, tubular reabsorption by the proximal tubules, and interstitial retention of the tracers...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27520932/neuroendocrine-tumor-liver-metastases-treated-with-yttrium-90-radioembolization
#17
Katherine Y Fan, Aaron T Wild, Vivek G Halappa, Rachit Kumar, Susannah Ellsworth, Mark Ziegler, Tanu Garg, Lauren M Rosati, Zheng Su, Amy Hacker-Prietz, Timothy M Pawlik, David P Cosgrove, Kelvin K Hong, Ihab R Kamel, Jean-Francois Geschwind, Joseph M Herman
OBJECTIVE: Yttrium-90 (Y-90) radioembolization is an emerging treatment option for unresectable neuroendocrine liver metastases (NELM). However, the data regarding this treatment are currently limited. This study evaluates the efficacy and tolerability of Y-90 radioembolization and identifies prognostic factors for radiographic response and survival. METHODS AND MATERIALS: Thirty-eight patients underwent Y-90 radioembolization for NELM at our institution between April 2004 and February 2012...
September 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27495914/abdo-man-a-3d-printed-anthropomorphic-phantom-for-validating-quantitative-sirt
#18
Jonathan I Gear, Craig Cummings, Allison J Craig, Antigoni Divoli, Clive D C Long, Michael Tapner, Glenn D Flux
BACKGROUND: The use of selective internal radiation therapy (SIRT) is rapidly increasing, and the need for quantification and dosimetry is becoming more widespread to facilitate treatment planning and verification. The aim of this project was to develop an anthropomorphic phantom that can be used as a validation tool for post-SIRT imaging and its application to dosimetry. METHOD: The phantom design was based on anatomical data obtained from a T1-weighted volume-interpolated breath-hold examination (VIBE) on a Siemens Aera 1...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27487894/optimization-of-yttrium-90-pet-for-simultaneous-pet-mr-imaging-a-phantom-study
#19
Mootaz Eldib, Niels Oesingmann, David D Faul, Lale Kostakoglu, Karin Knešaurek, Zahi A Fayad
PURPOSE: Positron emission tomography (PET) imaging of yttrium-90 in the liver post radioembolization has been shown useful for personalized dosimetry calculations and evaluation of extrahepatic deposition. The purpose of this study was to quantify the benefits of several MR-based data correction approaches offered by using a combined PET/MR system to improve Y-90 PET imaging. In particular, the feasibility of motion and partial volume corrections were investigated in a controlled phantom study...
August 2016: Medical Physics
https://www.readbyqxmd.com/read/27407269/efficacy-of-radiation-synovectomy-radiosynovectomy-or-radiosynoviorthesis-with-yttrium-90-in-exudative-inflammation-of-synovial-membrane-of-knee-joints-in-patients-with-rheumatic-diseases-preliminary-report
#20
Joanna Zalewska, Małgorzata Węgierska, Tacjana Barczyńska, Marzena Waszczak, Paweł Żuchowski, Sławomir Jeka
OBJECTIVES: Hypertrophic and exudative synovitis of the knee is one of the earliest symptoms in rheumatic diseases. In the case of pharmacotherapy failure, other methods which directly remove the inflamed synovial membrane are used - synovectomies. Radiosynovectomy (RSV) is the radiopharmaceutical application of colloidal solution to joint cavities. In this study, the authors assessed the efficacy of knee radiosynovectomy with yttrium-90 (Y-90) in several groups of patients divided into certain rheumatic diseases...
2016: Reumatologia
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