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Benjamin Benzon, Stephanie A Glavaris, Brian W Simons, Robert M Hughes, Kamyar Ghabili, Patrick Mullane, Rebecca Miller, Katriana Nugent, Brian Shinder, Jeffrey Tosoian, Ephraim J Fuchs, Phuoc T Tran, Paula J Hurley, Milena Vuica-Ross, Edward M Schaeffer, Charles G Drake, Ashley E Ross
BACKGROUND: Prostate cancer remains the second leading cause of cancer related death in men. Immune check point blocking antibodies have revolutionized treatment of multiple solid tumors, but results in prostate cancer remain marginal. Previous reports have suggested that local therapies, in particular cryoablation might increase tumor immunogenicity. In this work, we examine potential synergism between tumor cryoabalation and check point blocking antibodies. METHODS: FVB/NJ mice were injected subcutaneously into each flank with either 1 × 106 or 0...
March 20, 2018: Prostate Cancer and Prostatic Diseases
Cagdas Baran, Mustafa Serkan Durdu, Fatih Gumus, Mehmet Cakici, Mustafa Bahadir Inan, Mustafa Sirlak, Ahmet Ruchan Akar
OBJECTIVES: Sutureless aortic valve replacement (SU-AVR) is an alternative technique to standard aortic valve replacement. We evaluated our experience with the Perceval SU-AVR with concomitant mitral valve surgery, with or without tricuspid valve surgery, and aimed to discuss the technical considerations. METHODS: From January 2013 through June 2016, 30 patients with concomitant severe mitral valve disease, with or without tricuspid valve disease, underwent SU-AVR with the Perceval prosthesis in a single center...
February 21, 2018: Journal of Thoracic and Cardiovascular Surgery
Junichi Tokuda, Laurent Chauvin, Brian Ninni, Takahisa Kato, Franklin King, Kemal Tuncali, Nobuhiko Hata
Patient-mounted needle guide devices for
 percutaneous ablations are vulnerable to patient motion. The objective of this study is to develop and evaluate a software system for MRI-compatible patient-mounted needle guide device that can adaptively compensate for the displacement of the device due to the patient motion using a novel image-based automatic device-to-image registration.
 Materials and Methods. We developed a software system for an MRI-compatible patient-mounted needle guide device for percutaneous ablations...
March 16, 2018: Physics in Medicine and Biology
Yuriy Mandryk, Markus Czesla, Parwis Massoudy
The strategy for the successful removal of gigantic myxoma of the left atrium obstructing inflow into the left ventricle is presented. We consider an anterolateral minithoracotomy approach superior to median sternotomy for complete and comfortable atrial tumour excision because of the excellent exposure and the cosmetic outcome. After removal, local cryodestruction of potential remnant cells is mandatory to prevent recurrency.
March 12, 2018: Interactive Cardiovascular and Thoracic Surgery
Shiwei Huang, Binglin Pan, He Zou, Wei Lin
BACKGROUND: Atrial fibrillation (AF) usually originates from pulmonary veins (PVs) but can also be caused by pulmonary veins outside, such as the coronary sinus (CS), the superior vena cava (SVC), and the ligament of Marshall. CASE PRESENTATION: A 69-year-old male with a history of palpitations for 10 years was referred to our institute because of its recurrence for half a day. A dynamic electrocardiogram revealed sinus rhythm (SR) and paroxysmal AF. Echocardiography demonstrated normal cardiac structure, and physical examination results were unremarkable...
March 13, 2018: BMC Cardiovascular Disorders
Margaux Alazard, Jérôme Lacotte, Jérôme Horvilleur, Mina Ait-Said, Fiorella Salerno, Vladimir Manenti, Jean-François Piechaud, Jérôme Garot, Damien Bonnet, Alice Maltret
PURPOSE: To evaluate various strategies in order to minimize the risk of coronary injury during posteroseptal accessory pathways ablation in children. METHODS: We retrospectively reviewed 68 posteroseptal accessory pathways ablation procedures (20 decremental and 48 typical accessory pathways) performed in 62 pediatric patients at our institution between July 2009 and December 2016. Only posteroseptal accessory pathways targeted near or within the coronary sinus were included and ablation was mostly performed using irrigated tip radiofrequency...
March 12, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Giuseppe Maiolino, Michele Battistel, Giulio Barbiero, Valeria Bisogni, Gian Paolo Rossi
BACKGROUND: We herein report on a 20 years old woman with stage I hypertension, who was found to carry a renin-producing tumor (RPT). METHODS: Due to her young age, the patient underwent screening measurement of plasma renin and aldosterone, abdominal computed tomography (CT) angiography, and selective renal vein renin assessment to identify secondary hypertension. RESULTS: The patient was screened for secondary causes of hypertension and was diagnosed with secondary aldosteronism...
March 7, 2018: American Journal of Hypertension
Thea Buchan, Miles Walkden, Kathryn Jenkins, Pervez Sultan, Steve Bandula
AIM: To evaluate the effect of high-frequency jet ventilation (HFJV) in place of standard intermittent positive-pressure ventilation (IPPV) on procedure duration, patient radiation dose, complication rates, and outcomes during CT-guided cryoablation of small renal tumours. MATERIALS AND METHODS: One hundred consecutive CT-guided cryoablation procedures to treat small renal tumours under general anaesthesia were evaluated-50 with standard IPPV and 50 after the introduction of HFJV as standard practice...
March 7, 2018: Cardiovascular and Interventional Radiology
Benjamin West, Mohamed Keheila, Jason C Smith, Alexander Erskine, Samuel R Abourbih, Nazih Khater, D Duane Baldwin
Objective: Cryoablation of renal tumors adjacent to the ureter or pelvicalyceal system carries risks for thermal injury of the collecting system. Although cold antegrade perfusion has been described for radiofrequency ablation, warm saline perfusion for renal cryoablation has not been well-characterized. The purpose of this study was to determine the safety and feasibility of antegrade and retrograde warm saline perfusions during percutaneous renal cryoablation. Material and methods: A retrospective review was performed on 136 patients treated with percutaneous renal cryoablation at a single academic institution between 2009 and 2015...
March 2018: Turkish Journal of Urology
Collin H Schmit, Matthew R Callstrom, Stephen A Boorjian, Matthew P Johnson, Thomas D Atwell, A Nicholas Kurup, Georgianna R Schultz, R Houston Thompson, Grant D Schmit
PURPOSE: To determine if the use of heat-based track ablation with new-generation cryoprobes is associated with decreased renal cryoablation bleeding complications. MATERIALS AND METHODS: Eighty-nine patients who underwent percutaneous cryoablation for treatment of a solitary renal mass with the use of cryoprobes with track ablation (CwTA) from October 29, 2015, to May 18, 2017, were compared with a propensity score-matched control group of 178 patients who underwent treatment with the use of cryoprobes without track ablation (Cw/oTA) from January 5, 2012, to October 28, 2015...
March 3, 2018: Journal of Vascular and Interventional Radiology: JVIR
Patrick J Pan, Anshuman K Bansal, Scott J Genshaft, Grace H Kim, Robert D Suh, Fereidoun Abtin
PURPOSE: To determine size of ablation zone and pulmonary hemorrhage in double-freeze (DF) vs modified triple-freeze (mTF) cryoablation protocols with different probe sizes in porcine lung. MATERIALS AND METHODS: In 10 healthy adult pigs, 20 pulmonary cryoablations were performed using either a 2.4-mm or a 1.7-mm probe. Either conventional DF or mTF protocol was used. Serial noncontrast CT scans were performed during ablations. Ablation iceball and hemorrhage volumes were measured and compared between protocols and probe sizes...
March 3, 2018: Journal of Vascular and Interventional Radiology: JVIR
Duygu Kocyigit, Muhammed Ulvi Yalcin, Kadri Murat Gurses, Selin Ardali, Gamze Turk, Ugur Canpolat, Banu Evranos, Hikmet Yorgun, Tuncay Hazirolan, Kudret Aytemir
AIMS: Several studies have investigated the influence of pulmonary vein(PV) anatomy on outcomes of atrial fibrillation (AF) ablation. We aimed to evaluate the relationship between PV orientation and AF-free survival following cryoablation. METHODS: 160 patients scheduled for cryoablation between September 2012-March 2014 were included. Patients underwent a pre-procedural cardiac CT scan with retrospective ECG gating. PV orientation was assessed according to the position of the PV orifice relative to the sagittal plane with reference to coronal and horizontal planes...
February 19, 2018: Journal of Cardiovascular Computed Tomography
Andre Arantes Pereira Azevedo, Antonio Rahal, Priscila Mina Falsarella, Gustavo Caserta Lemos, Oliver Rojas Claros, Arie Carneiro, Marcos Roberto Gomes de Queiroz, Rodrigo Gobbo Garcia
OBJECTIVES: To describe the experience of our institution in image-guided renal nodules percutaneous cryoablation, evaluating demographic and technical aspects as well as efficacy, safety and follow up. MATERIALS AND METHODS: Retrospective study approved by our institutional review board. Seventy-one renal tumors evaluated in 60 patients treated with image guided percutaneous renal cryoablation from January 2009 to December 2015. No patient was excluded from study, even those who were lost on follow up...
March 2018: European Journal of Radiology
Ugur Canpolat, Duygu Kocyigit, Kudret Aytemir
Catheter ablation either by using radiofrequency or cryo energy in symptomatic patients with atrial fibrillation (AF) has shown to be effective as compared to anti-arrhythmic drugs. However, all the techniques used during AF ablation are not free of complication. There are several well-known peri-procedural complications in which operators should be informed of the possible risks, cautious during the procedure and able to manage them when occurred. Herein, we aimed to review possible complications of AF cryoablation...
December 2017: Journal of Atrial Fibrillation
Jian-Ying Zeng, Xiang-Hao Piao, Zhong-Yuan Zou, Qing-Feng Yang, Zi-Lin Qin, Ji-Bing Chen, Liang Zhou, Li-Zhi Niu, Jian-Guo Liu
This study aimed to explore the efficacy and safety of drug-eluting bead (DEB) embolization (DEB-TACE) when combined with cryoablation in the treatment of unresectable hepatocellular carcinoma (HCC). The study was a single-center randomized controlled trial comprised of 60 patients with HCC conducted between August 2015 and October 2017. The patients were randomly divided into two groups: DEB-TACE combined with cryoablation (DEB-TACE-Cryo group) or cryoablation alone (Cryo group). Inter-group differences in overall survival, progression-free survival, and adverse reactions were assessed...
January 26, 2018: Oncotarget
Andrés Alonso-García, Felipe Atienza, Pablo Ávila, Clara Ugueto, Miriam Centeno, Reyes Álvarez, Tomás Datino, Esteban González-Torrecilla, Evaristo Castellanos, Gerard Loughlin, Constancio Medrano, Ángel Arenal, Francisco Fernández-Avilés
INTRODUCTION AND OBJECTIVES: Catheter ablation has become the treatment of choice in an increasing number of arrhythmias in children and adolescents. There is still limited evidence of its use at a national level in Spain. The aim was to describe the characteristics and results of a modern monocentric series form a referral tertiary care centre. METHODS: Retrospective register of invasive procedures between 2004 and 2016 performed in patients under 17 years and recorded clinical characteristic, ablation methodology and acute and chronic results of the procedure...
February 23, 2018: Revista Española de Cardiología
Kimberly L Santucci, John M Baust, Kristi K Snyder, Robert G Van Buskirk, John G Baust
Vitamin D3 (VD3 ) is an effective adjunctive agent, enhancing the destructive effects of freezing in prostate cancer cryoablation studies. We investigated whether dose escalation of VD3 over several weeks, to model the increase in physiological VD3 levels if an oral supplement were prescribed, would be as or more effective than a single treatment 1 to 2 days prior to freezing. PC-3 cells in log phase growth to model aggressive, highly metabolically active prostate cancer were exposed to a gradually increasing dose of VD3 to a final dose of 80 nM over a 4-week period, maintained for 2 weeks at 80 nM, and then exposed to mild sublethal freezing temperatures...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
Jeffrey Forris Beecham Chick, Ravi N Srinivasa, Evan Johnson, Matthew L Osher, Anthony Hage, Joseph J Gemmete
In the published article the first sentence under the section heading Case Reports ("This study was conducted with the institutional review board approval and complied with the Health Insurance Portability and Accountability Act.") is incorrect. That sentence should be replaced with: "Case reports are exempt from IRB approval at the authors' institution. This study complied with the Health Insurance Portability and Accountability Act."
February 20, 2018: Cardiovascular and Interventional Radiology
Mario Matta, Matteo Anselmino, Federico Ferraris, Marco Scaglione, Fiorenzo Gaita
BACKGROUND: Radiofrequency and cryoballoon pulmonary vein isolation are common approaches for paroxysmal atrial fibrillation treatment, showing similar results in recent multicenter studies, including heterogeneous tools and protocols. The aim of this study is to compare prospectively in a single, high-volume center the outcome of paroxysmal atrial fibrillation ablation performed specifically by second-generation cryoballoon or contact force radiofrequency ablation. METHODS: Consecutive patients scheduled for paroxysmal atrial fibrillation transcatheter ablation have been included and prospectively followed up...
February 9, 2018: Journal of Cardiovascular Medicine
Baichuan Jiang, Wenpeng Gao, Daniel Kacher, Erez Nevo, Barry Fetics, Thomas C Lee, Jagadeesan Jayender
PURPOSE: In many clinical procedures such as cryoablation that involves needle insertion, accurate placement of the needle's tip at the desired target is the major issue for optimizing the treatment and minimizing damage to the neighboring anatomy. However, due to the interaction force between the needle and tissue, considerable error in intraoperative tracking of the needle tip can be observed as needle deflects. METHODS: In this paper, measurements data from an optical sensor at the needle base and a magnetic resonance (MR) gradient field-driven electromagnetic (EM) sensor placed 10 cm from the needle tip are used within a model-integrated Kalman filter-based sensor fusion scheme...
February 7, 2018: International Journal of Computer Assisted Radiology and Surgery
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