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Catheter Related bloodstream infections

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https://www.readbyqxmd.com/read/28448786/microbiological-features-and-clinical-impact-of-the-type-vi-secretion-system-t6ss-in-acinetobacter-baumannii-isolates-causing-bacteremia
#1
Jungok Kim, Ji-Young Lee, Haejeong Lee, Ji Young Choi, Dae Hun Kim, Yu Mi Wi, Kyong Ran Peck, Kwan Soo Ko
We investigated the genetic background and microbiological features of T6SS-positive Acinetobacter baumannii isolates and clinical impact of the T6SS in patients with A. baumannii bacteremia. One hundred and sixty-two A. baumannii isolates from patients with bacteremia in two tertiary-care hospitals in Korea were included in this study. Approximately one-third (51/162, 31.5%) of the A. baumannii clinical isolates possessed the hcp gene, and the hcp-positive isolates were found in several genotypes in multilocus sequence typing...
April 27, 2017: Virulence
https://www.readbyqxmd.com/read/28416559/a-novel-non-antibiotic-nitroglycerin-based-catheter-lock-solution-for-the-prevention-of-intraluminal-central-venous-catheter-infections-in-cancer-patients
#2
Anne-Marie Chaftari, Ray Hachem, Ariel Szvalb, Mahnaz Taremi, Bruno Granwehr, George Michael Viola, Amin Sapna, Andrew Assaf, Numan Yazan, Pankil Shah, Ketevan Gasitashvili, Elizabeth Natividad, Ying Jiang, Rebecca Slack, Ruth Reitzel, Joel Rosenblatt, Elie Mouhayar, Issam Raad
Background: For long-term central lines (CL), the lumen is the major source of central line associated bloodstream infections (CLABSI). Current standard of care for maintaining catheter patency includes flushing the CL with saline or heparin. Neither agent has any antimicrobial activity. Furthermore heparin may enhance staphylococcal biofilm formation. We evaluated the safety and efficacy of a novel non-antibiotic catheter lock solution for the prevention of CLABSI.Patients and Methods: Between November 2015, and February 2016, we enrolled 60 patients with hematologic malignancies who had peripherally inserted central catheter (PICC) to receive the study lock solution...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28415937/heparinized-saline-versus-normal-saline-for-maintaining-peripheral-venous-catheter-patency-in-china-an-open-label-randomized-controlled-study
#3
Lichun Xu, Yan Hu, Xiaojin Huang, Jianguo Fu, Jinhui Zhang
Objective To evaluate the effects of heparin saline versus normal saline as locking solution for maintaining patency in peripheral venous catheters in Chinese patients. Methods This open-label, randomized controlled study was conducted in two hepatobiliary surgery wards, where patients received identical treatments, at a tertiary referral hospital. Patients were randomly divided into a normal saline group (NS, 3 ml) or a heparin saline group (HS, 50 IU/ml, 3 ml) for catheter sealing. Results The study enrolled 286 patients and 609 peripheral venous catheters were included in the analysis...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28409898/comparing-catheter-related-bloodstream-infections-in-pediatric-and-adult-cancer-patients
#4
Ramia Zakhour, Ray Hachem, Hussain M Alawami, Ying Jiang, Majd Michael, Anne-Marie Chaftari, Issam Raad
OBJECTIVE: Central venous catheters (CVCs) are essential to treatment of children with cancer. There are no studies comparing catheter-related bloodstream infections (CRBSIs) in pediatric cancer patients to those in adults, although current guidelines for management of CRBSI do not give separate guidelines for the pediatric population. In this study, we compared CRBSIs in both the pediatric and adult cancer population. METHODS: We retrospectively reviewed the electronic medical records of 92 pediatric and 156 adult patients with CRBSI cared for at MD Anderson Cancer Center between September 2005 and March 2014...
April 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28407421/central-venous-catheters-and-biofilms-where-do-we-stand-in-2017
#5
REVIEW
Marie Gominet, Fabrice Compain, Christophe Beloin, David Lebeaux
The use of central venous catheters (CVC) is associated with a risk of microbial colonization and subsequent potentially severe infection. Microbial contamination of the catheter leads to the development of a microbial consortia associated with the CVC surface and embedded in an extracellular matrix, named biofilm. This biofilm provides bacterial cells the ability to survive antimicrobial agents and the host immune system and to disseminate to other sites of the body. The best preventive strategy is to avoid any unnecessary catheterization or to reduce indwelling duration when a CVC is required...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28397261/validity-and-reliability-of-administrative-coded-data-for-the-identification-of-hospital-acquired-infections-an-updated-systematic-review-with-meta-analysis-and-meta-regression-analysis
#6
Olga Redondo-González, José María Tenías, Ángel Arias, Alfredo J Lucendo
OBJECTIVE: To conduct an updated assessment of the validity and reliability of administrative coded data (ACD) in identifying hospital-acquired infections (HAIs). METHODS: We systematically searched three libraries for studies on ACD detecting HAIs compared to manual chart review. Meta-analyses were conducted for prosthetic and nonprosthetic surgical site infections (SSIs), Clostridium difficile infections (CDIs), ventilator-associated pneumonias/events (VAPs/VAEs) and non-VAPs/VAEs, catheter-associated urinary tract infections (CAUTIs), and central venous catheter-related bloodstream infections (CLABSIs)...
April 11, 2017: Health Services Research
https://www.readbyqxmd.com/read/28380162/positive-deviance-as-a-strategy-to-prevent-and-control-bloodstream-infections-in-intensive-care
#7
Francimar Tinoco de Oliveira, Maria Manuela Frederico Ferreira, Silvia Teresa Carvalho de Araújo, Amanda Trindade Teixeira de Bessa, Advi Catarina Barbachan Moraes, Marluci Andrade Conceição Stipp
OBJECTIVE: To describe the application of positive deviance as a strategy to prevent and control bloodstream infections. METHOD: An intervention study with nursing and medical team members working in an intensive care unit in a university hospital, between June and December 2014. The four steps of the positive defiance methodology were applied: to define, to determine, to discover and to design. RESULTS: In 90 days, 188 actions were observed, of these, 36...
April 3, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28379553/high-vancomycin-mics-predict-the-development-of-infective-endocarditis-in-patients-with-catheter-related-bacteraemia-due-to-methicillin-resistant-staphylococcus-aureus
#8
Rafael San-Juan, Mario Fernández-Ruiz, Oriol Gasch, Mariana Camoez, Francisco López-Medrano, María Ángeles Domínguez, Benito Almirante, Belén Padilla, Miquel Pujol, José María Aguado
Background: It has been suggested that there is an increased risk of treatment failure in episodes of MRSA bloodstream infection (BSI) caused by strains with high vancomycin MICs. However, it is unknown if this phenomenon may also act as a risk factor for the development of infective endocarditis (IE). Methods: We analysed 207 episodes of catheter-related (CR)-BSI recruited from June 2008 to December 2009 within a prospective study on MRSA BSI in 21 Spanish hospitals...
March 31, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28376269/central-line-associated-bloodstream-infections-in-childhood-malignancies-single-center-experience
#9
Marianna Miliaraki, Nikolaos Katzilakis, Ioanna Chranioti, Maria Stratigaki, Maria Koutsaki, Maria Psarrou, Emmanouil Athanasopoulos, Eftichia Stiakaki
BACKGROUND: A central line-associated bloodstream infection (CLABSI) is a common complication in children with malignancies, often leading to prolonged hospitalization, delay in chemotherapy or catheter removals. This retrospective epidemiological study reviewed 91 children with malignancies over a 5-year period between 2011 and 2015 and analyzed potential risk factors for developing a CLABSI. METHODS: Children's symptoms, laboratory and microbiology characteristics, subsequent treatment and outcome were recorded and analyzed...
April 4, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28359216/revisiting-ultrasound-guided-subclavian-axillary-vein-cannulations
#10
Mourad H Senussi, Phani C Kantamneni, Ali Omranian, Mani Latifi, Tarik Hanane, Eduardo Mireles-Cabodevila, Neal F Chaisson, Abhijit Duggal, Ajit Moghekar
The Centers for Disease Control and Prevention guidelines for the prevention of catheter-related bloodstream infections suggest using "a subclavian site, rather than an internal jugular or a femoral site, in adult patients." This recommendation is based on evidence of lower rates of thrombosis and catheter-related bloodstream infections in patients with subclavian central venous catheters (CVCs) compared to femoral or internal jugular sites. However, preference toward a subclavian approach to CVC insertion is hindered by increased risk of mechanical complications, especially pneumothorax, when compared to other sites...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28341283/are-antimicrobial-peripherally-inserted-central-catheters-associated-with-reduction-in-central-line-associated-bloodstream-infection-a-systematic-review-and-meta-analysis
#11
Rachel D Kramer, Mary A M Rogers, Marisa Conte, Jason Mann, Sanjay Saint, Vineet Chopra
BACKGROUND: Antimicrobial peripherally inserted central catheters (PICCs) may reduce the risk of central line-associated bloodstream infection (CLABSI). However, data regarding efficacy are limited. We aimed to evaluate whether antimicrobial PICCs are associated with CLABSI reduction. METHODS: MEDLINE, EMBASE, CINHAL, and Web of Science were searched from inception to July 2016; conference proceedings were searched to identify additional studies. Study selection and data extraction were performed independently by 2 authors...
February 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28334494/complications-of-peripherally-inserted-central-catheters-in-advanced-cancer-patients-undergoing-combined-radiotherapy-and-chemotherapy
#12
Jun Xie, Linjie Xu, Xiaomin Xu, Yunjuan Huang
AIMS AND OBJECTIVES: This study aimed to identify whether patients with advanced cancers were at high risk of peripherally inserted central catheter (PICC)-related complications when treated with concurrent chemo-radiotherapy. BACKGROUND: PICCs are widely used in chemotherapy. However, catheter usage may elevate the risks of infections and thrombosis. It is important to identify the patients with high risk of PICC-related complications. To date, little is known about PICC-related complications in patients with advanced cancers and receiving concurrent chemo-radiotherapy...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28323880/randomized-controlled-trials-in-central-vascular-access-devices-a-scoping-review
#13
Mari Takashima, Gillian Ray-Barruel, Amanda Ullman, Samantha Keogh, Claire M Rickard
BACKGROUND: Randomized controlled trials evaluate the effectiveness of interventions for central venous access devices, however, high complication rates remain. Scoping reviews map the available evidence and demonstrate evidence deficiencies to focus ongoing research priorities. METHOD: A scoping review (January 2006-December 2015) of randomized controlled trials evaluating the effectiveness of interventions to improve central venous access device outcomes; including peripherally inserted central catheters, non-tunneled, tunneled and totally implanted venous access catheters...
2017: PloS One
https://www.readbyqxmd.com/read/28265408/catheter-related-thrombosis-diagnosed-by-computed-tomography
#14
Yohei Yamauchi, Akira Baba, Yumi Okuyama
Catheter-related bloodstream infection can be detected with CT. Although it is not mandatory for its diagnosis, it is strong evidence as a cause of fever if detected incidentally.
March 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28254252/improvement-in-the-diagnosis-of-catheter-related-bloodstream-infections-in-a-tertiary-cancer-center
#15
Patrick Chaftari, Anne-Marie Chaftari, Javier Adachi, Ray Hachem, Sammy Raad, Elizabeth Natividad, Nora Oliver, Bena Ellickalputhenpura, Ying Jiang, Jeffrey Tarrand, Issam Raad
BACKGROUND: Identifying a central venous catheter (CVC) as the source of bacteremia requires drawing simultaneous blood cultures (BCs) from the CVC and peripheral site and correct labeling of the BC source. In our emergency center (EC), 52% of BCs collected from febrile cancer patients lacked source information, making the diagnosis and management of catheter-related bloodstream infections (CRBSIs) challenging. METHODS: Between January 2015 and June 2015, we conducted a quality improvement project in our EC aiming to increase the occurrence of simultaneous BC drawing with accurate source labeling by 10%...
March 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28237984/effect-of-a-quality-improvement-program-to-improve-guideline-adherence-and-attainment-of-clinical-standards-in-dialysis-care-report-of-outcomes-in-year-1
#16
Sajeda Youssouf, Azri Nache, Chandrakumaran Wijesekara, Rachel J Middleton, David Lewis, Aladdin E Shurrab, Edmond O'Riordan, Lesley P Lappin, Donal O'Donoghue, Philip A Kalra, Janet Hegarty
BACKGROUND: Best practice in dialysis is synthesised in clear international guidelines. However, a large gap remains between the international guidelines and the actual delivery of care. In this paper, we report outcomes for the first year of a multifaceted dialysis improvement programme in our network. METHODS: One year collaborative involving 3 haemodialysis units and a peritoneal dialysis (PD) programme involving 299 dialysis patients. Each unit addressed a different indicator (unit A - catheter-related bloodstream infection [CRBSI], unit B - pre-dialysis blood pressure [BP], unit C - dialysis dose, unit D - anaemia) with a shared aim to match the top 10% in the UK...
February 25, 2017: Nephron
https://www.readbyqxmd.com/read/28224103/management-of-parenteral-nutrition-in-critically-ill-patients
#17
REVIEW
Paolo Cotogni
Artificial nutrition (AN) is necessary to meet the nutritional requirements of critically ill patients at nutrition risk because undernutrition determines a poorer prognosis in these patients. There is debate over which route of delivery of AN provides better outcomes and lesser complications. This review describes the management of parenteral nutrition (PN) in critically ill patients. The first aim is to discuss what should be done in order that the PN is safe. The second aim is to dispel "myths" about PN-related complications and show how prevention and monitoring are able to reach the goal of "near zero" PN complications...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28218366/peripherally-inserted-central-catheter-related-complications-in-cancer-patients-a-prospective-study-of-over-50-000-catheter-days
#18
Junren Kang, Wei Chen, Wenyan Sun, Ruibin Ge, Hailong Li, Enling Ma, Qingxia Su, Fang Cheng, Jinhua Hong, Yuanjuan Zhang, Cheng Lei, Xinchuan Wang, Aiyun Jin, Wanli Liu
PURPOSE: To evaluate incidence and risk factors of peripherally inserted central catheter (PICC)-related complications in cancer patients. METHODS: A prospective, multicenter, cohort study of cancer patients with PICC insertion was performed from February 1, 2013 to April 24, 2014. All patients were monitored in clinic until PICCs were removed. The primary endpoint was PICC removal due to complications. Patient-, catheter- and insertion-related factors were analyzed in univariable and multivariable logistic regression analysis to identify significant independent risk factors for PICC-related complications...
March 21, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28214161/human-factors-related-to-time-dependent-infection-control-measures-scrub-the-hub-for-venous-catheters-and-feeding-tubes
#19
Lindsay Caspari, Elizabeth Epstein, Amy Blackman, Li Jin, David A Kaufman
BACKGROUND: The use of catheter hub decontamination protocols is a common practice to reduce central line-associated bloodstream infections. However, few data exist on the most effective disinfection procedure prior to hub access accounting for human factors and time-dependent practices in real time in the clinical setting. METHODS: An observational design with a multimodal intervention was used in this study in a neonatal intensive care unit. Direct observations on nurse compliance of scrub times with decontamination when accessing of venous catheter and feeding tube hubs were conducted during 3 phases: (1) baseline period prior to any interventions; (2) during an educational intervention phase; and (3) during a timer intervention period when using a timing device, either an actual timer or music button...
February 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28213809/the-correlation-between-biofilm-production-and-catheter-related-blood-stream-infections-sustained-by-candida-a-case-control-study
#20
Grazia Brunetti, Valeria Visconti, Maria Cristina Ghezzi, Alessandra Giordano, Giammarco Raponi
Biofilm forming capacity of yeasts colonizing the intravenous devices is considered a key factor involved in the pathogenesis of Candida catheter-related bloodstream infections (CCRBSI). The biofilm production of strains of Candida spp. isolated both from the CVC and from the blood of patients with CCRBSI was compared to that of strains isolated from patients not having CCRBSI. Results, expressed in terms of Biofilm Index (BI), revealed that biofilm-producing strains were isolated in the CCRBSI group with a frequency significantly higher than in the non-CCRBSI group (χ(2) = 4...
February 18, 2017: Advances in Experimental Medicine and Biology
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