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https://www.readbyqxmd.com/read/29784501/consequences-of-quality-of-reduction-on-osteosynthesis-complications-and-quality-of-life-in-elderly-patients-with-subtrochanteric-fracture
#1
P Codesido-Vilar, A Mejía-Casado, J Riego-Fernández, N Rodriguez-Casas, S García-Cabanas, J Rivas-Felice, L García-Quevedo
OBJECTIVE: To compare results in terms of orthopaedic complications and quality of life in elderly patients with subtrochanteric fracture treated with intramedullary nailing according to fracture reduction status. PATIENTS AND METHODS: A prospective cohort study including 90 elderly patients with subtrochanteric fractures of the femur treated with a cephalomedullary nail, with a minimum 1-year follow up. The inclusion criteria were: aged 60 years or older, without severe cognitive dysfunction and independent ambulatory capability before the fracture...
May 18, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29760699/tetraspanin-cd9-a-key-regulator-of-cell-adhesion-in-the-immune-system
#2
REVIEW
Raquel Reyes, Beatriz Cardeñes, Yesenia Machado-Pineda, Carlos Cabañas
The tetraspanin CD9 is expressed by all the major subsets of leukocytes (B cells, CD4+ T cells, CD8+ T cells, natural killer cells, granulocytes, monocytes and macrophages, and immature and mature dendritic cells) and also at a high level by endothelial cells. As a typical member of the tetraspanin superfamily, a prominent feature of CD9 is its propensity to engage in a multitude of interactions with other tetraspanins as well as with different transmembrane and intracellular proteins within the context of defined membranal domains termed tetraspanin-enriched microdomains (TEMs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29760691/extracellular-vesicle-heterogeneity-subpopulations-isolation-techniques-and-diverse-functions-in-cancer-progression
#3
REVIEW
Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J A Wood, Pieter Vader
Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs) that function as mediators of intercellular communication by transferring biological information between cells. Tumor-derived EVs have emerged as important mediators in cancer development and progression, mainly through transfer of their bioactive content which can include oncoproteins, oncogenes, chemokine receptors, as well as soluble factors, transcripts of proteins and miRNAs involved in angiogenesis or inflammation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29754661/catheter-ablation-versus-antiarrhythmic-drug-therapy-for-atrial-fibrillation-cabana-trial-study-rationale-and-design
#4
Douglas L Packer, Daniel B Mark, Richard A Robb, Kristi H Monahan, Tristram D Bahnson, Kathleen Moretz, Jeanne E Poole, Alice Mascette, Yves Rosenberg, Neal Jeffries, Hussein R Al-Khalidi, Kerry L Lee
The Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation (CABANA,NCT00911508)(1) trial is testing the hypothesis that the treatment strategy of percutaneous left atrial catheter ablation for the purpose of eliminating atrial fibrillation (AF) is superior to current state-of-the-art pharmacologic therapy. This international 140-center clinical trial was designed to randomize 2200 patients to a strategy of catheter ablation versus state-of-the-art rate or rhythm control drug therapy. Inclusion criteria include: 1) age> 65, or ≤65 with≥ 1 risk factor for stroke, 2) documented AF warranting treatment, and 3) eligibility for both catheter ablation and≥ 2 anti-arrhythmic or≥ 2 rate control drugs...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29745248/social-identity-in-new-mexicans-of-spanish-speaking-descent-highlights-limitations-of-using-standardized-ethnic-terminology-in-research
#5
Keith Hunley, Heather Edgar, Meghan Healy, Carmen Mosley, Graciela S Cabana, Frankie West
In this study, we evaluated the extent to which regional history has shaped the social identity nomenclature in New Mexicans of Spanish-speaking descent (NMSD). We asked 507 NMSD to list the social-identity terms they used to describe themselves and their parents, and we examined the correspondence between these choices and family ties to the region, birthplace, and continental ancestry. NMSD frequently identified using the regional terms "Nuevomexicano/a" (15%) and "Spanish" (12%). These individuals reported family ties to the region that predate New Mexican statehood...
July 2017: Human Biology
https://www.readbyqxmd.com/read/29715653/evaluation-of-previous-substance-dependence-genome-wide-significant-findings-in-a-spanish-sample
#6
Laura Pineda-Cirera, Judit Cabana-Domínguez, Carlos Roncero, Mònica Cozar, Lara Grau-López, Alfonso C Abad, Nieves Martínez-Luna, María Robles-Martínez, Cristina Sánchez-Mora, Josep Antoni Ramos-Quiroga, Miquel Casas, Marta Ribasés, Noèlia Fernàndez-Castillo, Bru Cormand
BACKGROUND: Substance dependence is a chronic and relapsing disorder explained by genetic and environmental risk factors. The aim of our study is to replicate previous genome-wide significant (GWS) hits identified in substance dependence in general or in cocaine dependence in particular using an independent sample from Spain. METHODS: We evaluated, in a Spanish sample of 1711 subjects with substance dependence (1011 of them cocaine dependent) and 1719 control individuals, three SNPs identified as GWS in previous studies: rs1868152 and rs2952621 (located near LINC02052 and LINC01854, respectively), associated with substance dependence, and rs2629540 (in the first intron of FAM53B), associated with cocaine dependence...
April 16, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29701642/characterization-of-ns5a-and-ns5b-resistance-associated-substitutions-from-genotype-1-hepatitis-c-virus-infected-patients-in-a-portuguese-cohort
#7
Ruben Brandão, Rute Marcelino, Fátima Gonçalves, Isabel Diogo, Ana Carvalho, Joaquim Cabanas, Inês Costa, Pedro Brogueira, Fernando Ventura, Ana Miranda, Kamal Mansinho, Perpétua Gomes
This study is focused on the prevalent NS5 coding region resistance-associated substitutions (RASs) in DAA-naive genotype (GT)1 HCV-infected patients and their potential impact on success rates. Plasma RNA from 81 GT1 HCV-infected patients was extracted prior to an in-house nested RT-PCR of the NS5 coding region, which is followed by Sanger population sequencing. NS5A RASs were present in 28.4% (23/81) of all GT1-infected patients with 9.9% (8/81) having the Y93C/H mutation. NS5B RASs showed a prevalence of 14...
April 26, 2018: Viruses
https://www.readbyqxmd.com/read/29691206/designing-for-clinical-change-creating-an-intervention-to-implement-new-statin-guidelines-in-a-primary-care-clinic
#8
Melissa DeJonckheere, Claire H Robinson, Lindsey Evans, Julie Lowery, Bradley Youles, Adam Tremblay, Caitlin Kelley, Jeremy B Sussman
BACKGROUND: Recent clinical practice guidelines from major national organizations, including a joint United States Department of Veterans Affairs (VA) and Department of Defense (DoD) committee, have substantially changed recommendations for the use of the cholesterol-lowering statin medications after years of relative stability. Because statin medications are among the most commonly prescribed treatments in the United States, any change in their use may have significant implications for patients and providers alike...
April 24, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29684376/angiotensin-ii-cyclic-analogs-as-tools-to-investigate-at-1-r-biased-signaling-mechanisms
#9
David St-Pierre, Jérôme Cabana, Brian J Holleran, Élie Besserer-Offroy, Emanuel Escher, Gaétan Guillemette, Pierre Lavigne, Richard Leduc
G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be significantly investigated. However, an important but often overlooked aspect of functional selectivity is the capability of ligands such as angiotensin II (AngII) to adopt specific conformations that may preferentially bind to selective GPCRs structures...
April 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29676800/validation-of-an-in-vitro-sun-protection-factor-spf-method-in-blinded-ring-testing
#10
M Pissavini, C Tricaud, G Wiener, A Lauer, M Contier, L Kolbe, C Trullás Cabanas, F Boyer, V Nollent, E Meredith, E Dietrich, P J Matts
OBJECTIVE: The objective of this work was to investigate the utility of a new in vitro SPF test method in blinded ring-testing, against new ISO acceptance criteria. METHODS: 24 blinded, commercial, emulsion-type, primary sunscreen products, covering the full range of labelled SPF in Europe (SPF6 - 50+), were tested by 3 test institutes using the current ISO24444:2010 In Vivo SPF Test Method and simultaneously by 3 separate test laboratories using a new candidate in vitro SPF test method, developed under the leadership of Cosmetics Europe (CE)...
April 20, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29671924/effects-of-syn1-q555x-mutation-on-cortical-gray-matter-microstructure
#11
Jean-François Cabana, Guillaume Gilbert, Laurent Létourneau-Guillon, Dima Safi, Isabelle Rouleau, Patrick Cossette, Dang Khoa Nguyen
A new Q555X mutation on the SYN1 gene was recently found in several members of a family segregating dyslexia, epilepsy, and autism spectrum disorder. To describe the effects of this mutation on cortical gray matter microstructure, we performed a surface-based group study using novel diffusion and quantitative multiparametric imaging on 13 SYN1Q555X mutation carriers and 13 age- and sex-matched controls. Specifically, diffusion kurtosis imaging (DKI) and neurite orientation and dispersion and density imaging (NODDI) were used to analyze multi-shell diffusion data and obtain parametric maps sensitive to tissue structure, while quantitative metrics sensitive to tissue composition (T1, T2* and relative proton density [PD]) were obtained from a multi-echo variable flip angle FLASH acquisition...
April 19, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29667936/automated-algorithms-for-detecting-sleep-period-time-using-a-multi-sensor-pattern-recognition-activity-monitor-from-24-h-free-living-data-in-older-adults
#12
Veronica Cabanas-Sanchez, Sara Higueras-Fresnillo, Miguel Ángel De La Camara, Oscar L Veiga, David Martinez-Gomez
The aims of the present study were: (i) to develop automated algorithms to identify the sleep period time in 24-h data from the Intelligent Device for Energy Expenditure and Activity (IDEEA) in older adults, and (ii) to analyze the agreement of these algorithms to identify the sleep period time as compared to self-reported data and expert visual analysis of accelerometer raw data.
 Approach. This study comprised 50 participants, aged 65 to 85 years. Fourteen automated algorithms were developed. Participants reported their bedtime and wake time in the days wearing the device...
April 18, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29667748/accumulation-and-sublethal-effects-of-triclosan-and-its-transformation-product-methyl-triclosan-in-the-earthworm-eisenia-andrei-exposed-to-environmental-concentrations-in-an-artificial-soil
#13
Fanny Chevillot, Mélanie Guyot, Mélanie Desrosiers, Nicole Cadoret, Éloïse Veilleux, Hubert Cabana, Jean-Philippe Bellenger
Municipal biosolids are increasingly used as a low-cost fertilizer in agricultural soil. Biosolids are contaminated by low concentrations (ng g-1 dw range) of a large variety of organic contaminants, such as triclosan (TCS). The effect of exposure to low concentrations of organic contaminants on soil biota remains largely undocumented. We evaluated the sublethal effects of TCS on the earthworm Eisenia andrei using an artificial soil amended with a nominal concentration of TCS of 50 ng g-1 dry weight soil...
April 18, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29661742/overlap-between-dress-syndrome-and-exanthema-induced-by-sulfadiazine-in-a-patient-treated-with-sulfamethoxazole-utility-of-the-lymphocyte-transformation-test-for-identification-of-the-culprit-drug
#14
O P Monge-Ortega, R Cabañas, A Fiandor, J Domínguez-Ortega, M González-Muñoz, S Quirce, M Lluch-Bernal, T Bellón
No abstract text is available yet for this article.
April 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29659784/left-atrial-geometry-and-outcome-of-atrial-fibrillation-ablation-results-from-the-multicentre-lago-af-study
#15
Felipe Bisbal, Francisco Alarcón, Angel Ferrero-de-Loma-Osorio, Juan Jose González-Ferrer, Concepción Alonso, Marta Pachón, Helena Tizón, Pilar Cabanas-Grandío, Manuel Sanchez, Eva Benito, Albert Teis, Ricardo Ruiz-Granell, Julián Pérez-Villacastín, Xavier Viñolas, Miguel Angel Arias, Ermengol Vallés, Enrique García-Campo, Ignacio Fernández-Lozano, Roger Villuendas, Lluís Mont
Aims: Left atrial (LA) remodelling is a key determinant of atrial fibrillation (AF) ablation outcome. Optimal methods to assess this process are scarce. LA sphericity is a shape-based parameter shown to be independently associated to procedural success. In a multicentre study, we aimed to test the feasibility of assessing LA sphericity and evaluate its capability to predict procedural outcomes. Methods and results: This study included consecutive patients undergoing first AF ablation during 2013...
April 12, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29618489/beyond-asian-specific-east-and-southeast-asian-races-or-ethnicities-associated-with-jaundice-readmission
#16
Michael G Bentz, Nancy Carmona, Manavi M Bhagwat, Lindsay M Thimmig, Jamal Saleh, Uchechukwu Eke, Jolene Kokroko, Rand Dadasovich, Brooke Rice, Michael D Cabana
OBJECTIVES: Clinical practice guidelines have recognized "Asian" and "East Asian" as risk factors for newborn jaundice and readmission. We sought to identify more detailed and specific, parent-identified races or ethnicities associated with jaundice readmission. METHODS: We conducted a case control study of 653 newborn infants born (2014-2016) at a West-Coast, urban hospital to examine specific parent-described races or ethnicities that are associated with newborn hospital readmissions for hyperbilirubinemia...
April 4, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29614023/genomic-influence-in-the-prevention-of-cardiovascular-diseases-with-a-sterol-based-treatment
#17
Ismael San Mauro Martín, Javier Andrés Blumenfeld Olivares, Eva Pérez Arruche, Esperanza Arce Delgado, María José Ciudad Cabañas, Elena Garicano Vilar, Luis Collado Yurrita
Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women)...
April 3, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29595859/nanocrystal-heterostructures-of-licoo-2-with-conformal-passivating-shells
#18
Bob Jin Kwon, Patrick J Phillips, Baris Key, Fulya Dogan, John W Freeland, Chunjoong Kim, Robert F Klie, Jordi Cabana
Stabilization of electrode-electrolyte interfaces is required to increase the energy stored in battery electrodes. Introducing redox-inactive ions on the electrode surface minimizes deleterious side reactions without affecting the bulk properties. A synthetic challenge exists to grow such layers conformally at each primary particle, to fully passivate interfaces that are buried in the final electrode architecture. The development of methods of sequential colloidal growth of complex oxides and overlayers, enabled by surfactant interactions, would provide novel means to advance toward this goal...
March 29, 2018: Nanoscale
https://www.readbyqxmd.com/read/29587879/rituximab-impedes-natural-killer-cell-function-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-patients-a-pilot-in-vitro-investigation
#19
Natalie Eaton, Hélène Cabanas, Cassandra Balinas, Anne Klein, Donald Staines, Sonya Marshall-Gradisnik
BACKGROUND: A recent in vitro pilot investigation reported Rituximab significantly reduced natural killer (NK) cell cytotoxicity in healthy donors. Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) is a debilitating disorder of unknown etiology. A consistent finding is a significant reduction in NK cell cytotoxicity. Rituximab has been reported having questionable potential therapeutic benefits for the treatment of CFS/ME, however, the potential effects of Rituximab on NK cell cytotoxicity in CFS/ME patients are yet to be determined...
March 27, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29576173/does-longer-breastfeeding-duration-decrease-the-risk-of-asthma
#20
Michael D Cabana
No abstract text is available yet for this article.
April 2018: Journal of Pediatrics
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