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https://www.readbyqxmd.com/read/28097684/feeding-asian-pangolins-an-assessment-of-current-diets-fed-in-institutions-worldwide
#1
Francis Cabana, Amy Plowman, Thai Van Nguyen, Shih-Chien Chin, Sung-Lin Wu, Hsuan-Yi Lo, Hirofumi Watabe, Fujio Yamamoto
Pangolins are ant specialists which are under intense threat from the illegal wildlife trade. Nutrition has notoriously been their downfall in captivity and is still an issue in regards to rescue and rehabilitation. We analyzed the nutrient content of diets used by institutions that are successfully keeping Asian pangolins and to assess the variety of the ingredients and nutrients, compared these with the nutritional requirements of potential nutritional model species. We performed intake studies at five institutions and also had data from three other institutions...
January 18, 2017: Zoo Biology
https://www.readbyqxmd.com/read/28049488/intracellular-trafficking-and-cellular-uptake-mechanism-of-phbv-nanoparticles-for-targeted-delivery-in-epithelial-cell-lines
#2
Juan P Peñaloza, Valeria Márquez-Miranda, Mauricio Cabaña-Brunod, Rodrigo Reyes-Ramírez, Felipe M Llancalahuen, Cristian Vilos, Fernanda Maldonado-Biermann, Luis A Velásquez, Juan A Fuentes, Fernando D González-Nilo, Maité Rodríguez-Díaz, Carolina Otero
BACKGROUND: Nanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale. One application of this technology is drug delivery systems based on nanoparticles obtained from natural or synthetic sources. An example of these systems is synthetized from poly(3-hydroxybutyrate-co-3-hydroxyvalerate), which is a biodegradable, biocompatible and a low production cost polymer. The aim of this work was to investigate the uptake mechanism of PHBV nanoparticles in two different epithelial cell lines (HeLa and SKOV-3)...
January 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28045261/intracellular-enzymes-contribution-to-the-biocatalytic-removal-of-pharmaceuticals-by-trametes-hirsuta
#3
Lounès Haroune, Sabrina Saibi, Hubert Cabana, Jean-Philippe Bellenger
The use of white rot fungi (WRF) for bioremediation of recalcitrant trace organic contaminants (TrOCs) is becoming greatly popular. Biosorption and lignin modifying enzymes (LMEs) are the most often reported mechanisms of action. Intracellular enzymes, such as cytochrome P450 (CYP450), have also been suggested to contribute. However, direct evidence of TrOCs uptake and intracellular transformation is lacking. The aim of this study was to evaluate the relative contribution of biosorption, extracellular LMEs activity, TrOCs uptake, and intracellular CYP450 on the removal of six nonsteroidal anti-inflammatories (NSAIs) by Trametes hirsuta...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27974914/modulating-the-extension-of-axillary-lymphadenectomy-for-early-stage-breast-cancer
#4
REVIEW
M Plesca, C Bordea, B El Houcheimi, E Ichim, A Blidaru
Axillary lymph node evaluation remains essential in breast cancer surgery, first as a prognostic factor, because it indicates the degree of dissemination of the disease to the main lymphatic drainage basin of the breast, and, on the other hand, as an element of preventing the local relapse. In the era of the sentinel lymph node, complete axillary lymphadenectomy, considered valuable until recently, but as therapeutic and diagnostic, has become an intervention performed increasingly rare in selected cases. Axillary lymphatic tissue resections are accompanied by morbidity (lymphedema, paresthesia, limitations of arm movement) and symptom magnitude is proportional to the extension of the intervention...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27955849/-gallbladder-volvulus-diagnostic-and-surgical-challenges
#5
Pedro Abadía-Barnó, Magdalena Coll-Sastre, Carmen Picón-Serrano, Alfonso Sanjuanbenito-Dehesa, Jacobo Cabañas-Montero
BACKGROUND: The gallbladder volvulus is defined as the rotation of the gallbladder on its mesentery along the axis of the cystic duct and cystic artery. It is an extremely rare surgical disease and definitive diagnosis is usually made during surgery. CASE REPORT: A 78 year old woman presented with upper right quadrant abdominal pain, with no comorbidities and no other accompanying symptoms. Analysis revealed haemodynamic instability and leukocytosis. Computed tomography of abdomen showed an acute cholecystitis...
December 9, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27888155/significant-hla-class-i-type-associations-with-aromatic-antiepileptic-drug-aed-induced-sjs-ten-are-different-from-those-found-for-the-same-aed-induced-dress-in-the-spanish-population
#6
Elena Ramírez, Teresa Bellón, Hoi Y Tong, Alberto M Borobia, Francisco J de Abajo, Victoria Lerma, Miguel A Moreno Hidalgo, José L Castañer, Rosario Cabañas, Ana Fiandor, Jessica González-Ramos, Pedro Herranz, Lucía Cachafeiro, Carlos González-Herrada, Olga González, José A Aramburu, Olga Laosa, Rafael Hernández, Antonio J Carcas, Jesús Frías
Aromatic antiepileptic drugs (AEDs) are among the drugs most frequently involved in severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS). This study investigated the associations between the genetic polymorphisms of HLA class-I and AED-induced SCARs in the Spanish population. HLA class-I genotypes were determined in AED (phenytoin[PHT],lamotrigine[LTG],carbamazepine[CBZ],phenobarbital[PB])-induced SJS/TEN (n=15) or DRESS (n=12) cases included in the Spanish SCAR registry, PIELenRed...
January 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27871751/regional-assessment-of-concentrations-and-sources-of-pharmaceutically-active-compounds-pesticides-nitrate-and-e-coli-in-post-glacial-aquifer-environments-canada
#7
Marion Saby, Marie Larocque, Daniele L Pinti, Florent Barbecot, Sylvain Gagné, Diogo Barnetche, Hubert Cabana
There is growing concern worldwide about the exposure of groundwater resources to pharmaceutically active compounds (PhACs) and agricultural contaminants, such as pesticides, nitrate, and Escherichia coli. For regions with a low population density and an abundance of water, regional contamination assessments are not carried out systematically due to the typically low concentrations and high costs of analyses. The objectives of this study were to evaluate regional-scale contaminant distributions in untreated groundwater in a rural region of Quebec (Canada)...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27836128/probiotic-use-in-at-risk-populations
#8
Mary Ellen Sanders, Daniel J Merenstein, Arthur C Ouwehand, Gregor Reid, Seppo Salminen, Michael D Cabana, George Paraskevakos, Gregory Leyer
OBJECTIVE: To inform health care providers about quality standards for manufacture of probiotic products being recommended for at-risk patient populations. SUMMARY: Probiotics are used in a variety of clinical settings, sometimes in at-risk populations for therapeutic endpoints. Although probiotics might not be approved as drugs, they are sometimes used for the prevention or treatment of disease. In the United States, and many regions of the world, probiotic products are marketed as dietary supplements (not drugs) and are therefore subject to different manufacturing and quality control standards than approved drugs are...
November 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27777180/individualized-therapy-for-persistent-asthma-in-young-children
#9
Anne M Fitzpatrick, Daniel J Jackson, David T Mauger, Susan J Boehmer, Wanda Phipatanakul, William J Sheehan, James N Moy, Ian M Paul, Leonard B Bacharier, Michael D Cabana, Ronina Covar, Fernando Holguin, Robert F Lemanske, Fernando D Martinez, Jacqueline A Pongracic, Avraham Beigelman, Sachin N Baxi, Mindy Benson, Kathryn Blake, James F Chmiel, Cori L Daines, Michael O Daines, Jonathan M Gaffin, Deborah Ann Gentile, W Adam Gower, Elliot Israel, Harsha Vardhan Kumar, Jason E Lang, Stephen C Lazarus, John J Lima, Ngoc Ly, Jyothi Marbin, Wayne Morgan, Ross E Myers, J Tod Olin, Stephen P Peters, Hengameh H Raissy, Rachel G Robison, Kristie Ross, Christine A Sorkness, Shannon M Thyne, Stanley J Szefler
BACKGROUND: Phenotypic presentations in young children with asthma are varied and might contribute to differential responses to asthma controller medications. METHODS: The Individualized Therapy for Asthma in Toddlers study was a multicenter, randomized, double-blind, double-dummy clinical trial in children aged 12 to 59 months (n = 300) with asthma necessitating treatment with daily controller (Step 2) therapy. Participants completed a 2- to 8-week run-in period followed by 3 crossover periods with daily inhaled corticosteroids (ICSs), daily leukotriene receptor antagonists, and as-needed ICS treatment coadministered with albuterol...
December 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27775318/-rocking-chair-type-metal-hybrid-supercapacitors
#10
Hyun Deog Yoo, Sang-Don Han, Ryan D Bayliss, Andrew A Gewirth, Bostjan Genorio, Nav Nidhi Rajput, Kristin A Persson, Anthony K Burrell, Jordi Cabana
Hybrid supercapacitors that follow a "rocking-chair"-type mechanism were developed by coupling divalent metal and activated carbon electrodes in nonaqueous electrolytes. Conventional supercapacitors require a large amount of electrolyte to provide a sufficient quantity of ions to the electrodes, due to their Daniell-type mechanism that depletes the ions from the electrolyte while charging. The alternative "rocking-chair"-type mechanism effectively enhances the energy density of supercapacitors by minimizing the necessary amount of electrolyte, because the ion is replenished from the metal anode while it is adsorbed to the cathode...
November 16, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27752700/design-synthesis-and-biological-evaluation-of-cxcr4-ligands
#11
Christine E Mona, Élie Besserer-Offroy, Jérôme Cabana, Richard Leduc, Pierre Lavigne, Nikolaus Heveker, Éric Marsault, Emanuel Escher
A combination of the CXCR4 inverse agonist T140 with N-terminal CXCL12 oligopeptides has produced the first nanomolar synthetic CXCR4 agonists. In these agonists, the inverse agonistic portion provides affinity whereas the N-terminal CXCL12 sequence induces receptor activation. Several CXCR4 crystal structures exist with either CVX15, an inverse agonist closely related to T140 and IT1t, a small molecule; we therefore attempted to produce another CXCL12 oligopeptide combination with IT1t. For this purpose, a primary amino group was introduced by total synthesis into one of the methyl groups of IT1t, serving as an anchoring point for the oligopeptide graft...
October 18, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27733612/sustained-gq-protein-signaling-disrupts-striatal-circuits-via-jnk
#12
Luigi Bellocchio, Andrea Ruiz-Calvo, Anna Chiarlone, Magali Cabanas, Eva Resel, Jean-René Cazalets, Cristina Blázquez, Yoon H Cho, Ismael Galve-Roperh, Manuel Guzmán
: The dorsal striatum is a major input structure of the basal ganglia and plays a key role in the control of vital processes such as motor behavior, cognition, and motivation. The functionality of striatal neurons is tightly controlled by various metabotropic receptors. Whereas the Gs/Gi-protein-dependent tuning of striatal neurons is fairly well known, the precise impact and underlying mechanism of Gq-protein-dependent signals remain poorly understood. Here, using different experimental approaches, especially designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found that sustained activation of Gq-protein signaling impairs the functionality of striatal neurons and we unveil the precise molecular mechanism underlying this process: a phospholipase C/Ca(2+)/proline-rich tyrosine kinase 2/cJun N-terminal kinase pathway...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27717073/migration-and-nutritional-status-of-tarahumara-schoolchildren-from-chihuahua-state-m%C3%A3-xico
#13
Zuliana Paola Benítez-Hernández, María de Lourdes De la Torre-Díaz, Mónica Cervantes-Borunda, Rosa Patricia Hernández-Torres, María Dolores Cabañas, Noemí López-Ejeda, María Dolores Marrodán
OBJECTIVE: The Tarahumara ethnic group is composed of indigenous people from the Sierra Madre Occidental of Mexico. Conditions of isolation and poverty compel them to migrate to the city in search of better opportunities. This work aims to explore the influence of migration on the growth and nutritional status of Tarahumara schoolchildren. METHODS: One hundred Tarahumara students were analyzed (50 rural with a mean age of 9.78 ± 1.25 years; 50 urban aged 10...
September 26, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27588019/nadph-thioredoxin-reductase-c-mediates-the-response-to-oxidative-stress-and-thermotolerance-in-the-cyanobacterium-anabaena-sp-pcc7120
#14
Ana M Sánchez-Riego, Alejandro Mata-Cabana, Carla V Galmozzi, Francisco J Florencio
NADPH-thioredoxin reductase C (NTRC) is a bimodular enzyme composed of an NADPH-thioredoxin reductase and a thiioredoxin domain extension in the same protein. In plants, NTRC has been described to be involved in the protection of the chloroplast against oxidative stress damage through reduction of the 2-Cys peroxiredoxin (2-Cys Prx) as well as through other functions related to redox enzyme regulation. In cyanobacteria, the Anabaena NTRC has been characterized in vitro, however, nothing was known about its in vivo function...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27573830/captivity-humanizes-the-primate-microbiome
#15
Jonathan B Clayton, Pajau Vangay, Hu Huang, Tonya Ward, Benjamin M Hillmann, Gabriel A Al-Ghalith, Dominic A Travis, Ha Thang Long, Bui Van Tuan, Vo Van Minh, Francis Cabana, Tilo Nadler, Barbara Toddes, Tami Murphy, Kenneth E Glander, Timothy J Johnson, Dan Knights
The primate gastrointestinal tract is home to trillions of bacteria, whose composition is associated with numerous metabolic, autoimmune, and infectious human diseases. Although there is increasing evidence that modern and Westernized societies are associated with dramatic loss of natural human gut microbiome diversity, the causes and consequences of such loss are challenging to study. Here we use nonhuman primates (NHPs) as a model system for studying the effects of emigration and lifestyle disruption on the human gut microbiome...
September 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27571657/-not-available
#16
Ismael San Mauro Martín, Elena Garicano Vilar, Joana León Fernández, María José Ciudad Cabañas, Luis Collado Yurrita
Introducción: recientemente ha surgido el interés por el posible papel de la microbiota intestinal como agente potenciador del rápido aumento que se está observando en el aumento de la prevalencia de obesidad en todo el mundo.Objetivos: relacionar las modificaciones que puede ocasionar el consumo de antibióticos en la microflora intestinal con la obesidad.Métodos: se extrajeron, de las Encuestas Nacionales de Salud de España, entre los años 2001 y 2011, las cifras de ingesta de antibióticos y la prevalencia (%) de obesidad en el mismo rango de edad, género y año...
July 19, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27570992/microbiological-quality-of-pediatric-oral-liquid-formulations
#17
Maria Josep Cabañas Poy, Carme Cañete Ramírez, Sabina X González di Lauro, Virginia Rodríguez Garrido, Gloria Roig Carbajosa, Aurora Fernández-Polo, Susana Clemente Bautista
The oral administration of drugs to the pediatric population involves the extemporaneous preparation of liquid formulations. These formulations have studies on their physicochemical stability, but they often lack microbiological studies. The objective of this study is to check the microbiological quality of five oral liquid formulations prepared with different excipients, which represent five major combinations, in two conditions: kept unopened until the day of the test, and in a multi-dose vial opened daily...
September 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27570627/is-an-in-home-telerehabilitation-program-for-people-with-proximal-humerus-fracture-as-effective-as-a-conventional-face-to-face-rehabilitation-program-a-study-protocol-for-a-noninferiority-randomized-clinical-trial
#18
François Cabana, Catherine Pagé, Amy Svotelis, Samuel Langlois-Michaud, Michel Tousignant
BACKGROUND: Proximal humerus fractures can be treated surgically (eg: pinning, plate and screws) or conservatively by wearing a splint or a cast. Following both of these approaches, rehabilitation has proven effective to prevent functional limitations and to re-establish normal shoulder function. However, access to these rehabilitation services and compliance tends to be limited in elderly patients due to travelling difficulties caused by their precarious health status and, in some cases, social and marital status...
2016: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27543764/eosinophilic-drug-reactions-detected-by-a-prospective-pharmacovigilance-programme-in-a-tertiary-hospital
#19
Elena Ramírez, Nicolás Medrano-Casique, Hoi Y Tong, Teresa Bellón, Rosario Cabañas, Ana Fiandor, Jessica González-Ramos, Pedro Herranz, Elena Trigo, Mario Muñoz, Alberto M Borobia, Antonio J Carcas, Jesús Frías
AIM: We conducted a prospective evaluation of all eosinophilic drug reactions (EDRs) through the Prospective Pharmacovigilance Program from Laboratory Signals at Hospital to find out the incidence and distribution of these entities in our hospital, their causative drugs, and predictors. METHODS: All peripheral eosinophilia >700 × 10(6)  cells l(-1) detected at admission or during hospitalisation, were prospectively monitored over 42 months. The spectrum of the localised or systemic manifestation of EDR, the incidence, the distribution of causative drugs, and the predictors were analysed...
August 20, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27532828/acetaminophen-versus-ibuprofen-in-young-children-with-mild-persistent-asthma
#20
RANDOMIZED CONTROLLED TRIAL
William J Sheehan, David T Mauger, Ian M Paul, James N Moy, Susan J Boehmer, Stanley J Szefler, Anne M Fitzpatrick, Daniel J Jackson, Leonard B Bacharier, Michael D Cabana, Ronina Covar, Fernando Holguin, Robert F Lemanske, Fernando D Martinez, Jacqueline A Pongracic, Avraham Beigelman, Sachin N Baxi, Mindy Benson, Kathryn Blake, James F Chmiel, Cori L Daines, Michael O Daines, Jonathan M Gaffin, Deborah A Gentile, W Adam Gower, Elliot Israel, Harsha V Kumar, Jason E Lang, Stephen C Lazarus, John J Lima, Ngoc Ly, Jyothi Marbin, Wayne J Morgan, Ross E Myers, J Tod Olin, Stephen P Peters, Hengameh H Raissy, Rachel G Robison, Kristie Ross, Christine A Sorkness, Shannon M Thyne, Michael E Wechsler, Wanda Phipatanakul
BACKGROUND: Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking. METHODS: In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 children (age range, 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks...
August 18, 2016: New England Journal of Medicine
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