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https://www.readbyqxmd.com/read/28336532/moag-4-promotes-the-aggregation-of-%C3%AE-synuclein-by-competing-with-self-protective-electrostatic-interactions
#1
Yuichi Yoshimura, Mats A Holmberg, Predrag Kukic, Camilla B Andersen, Alejandro Mata-Cabana, S Fabio Falsone, Michele Vendruscolo, Ellen A A Nollen, Frans A A Mulder
Aberrant protein aggregation underlies a variety of age-related neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Little is known, however, about the molecular mechanisms that modulate the aggregation process in the cellular environment. Recently, MOAG-4/SERF has been identified as a class of evolutionarily conserved proteins that positively regulates aggregate formation. Here, by using nuclear magnetic resonance (NMR) spectroscopy, we examine the mechanism of action of MOAG-4 by characterizing its interaction with α-synuclein (αSyn)...
March 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28306505/identification-of-an-rna-polymerase-iii-regulator-linked-to-disease-associated-protein-aggregation
#2
Olga Sin, Tristan de Jong, Alejandro Mata-Cabana, Michelle Kudron, Mohamad Amr Zaini, Francesco A Aprile, Renée I Seinstra, Esther Stroo, Roméo Willinge Prins, Céline N Martineau, Hai Hui Wang, Wytse Hogewerf, Anne Steinhof, Erich E Wanker, Michele Vendruscolo, Cornelis F Calkhoven, Valerie Reinke, Victor Guryev, Ellen A A Nollen
Protein aggregation is associated with age-related neurodegenerative disorders, such as Alzheimer's and polyglutamine diseases. As a causal relationship between protein aggregation and neurodegeneration remains elusive, understanding the cellular mechanisms regulating protein aggregation will help develop future treatments. To identify such mechanisms, we conducted a forward genetic screen in a C. elegans model of polyglutamine aggregation and identified the protein MOAG-2/LIR-3 as a driver of protein aggregation...
March 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28295653/paracoccidioidomycosis-infection-in-domestic-and-wild-mammals-by-paracoccidioides-lutzii
#3
Josiara F Mendes, Gabriel B Klafke, Ana Paula N Albano, Ângela L Cabana, Alessandra J Teles, Zoilo P de Camargo, Melissa O Xavier, Mário Carlos A Meireles
Paracoccidioidomycosis (PCM) is a systemic mycosis that occurs in several Latin American countries, especially in Brazil. It is caused by the thermo-dimorphic fungus Paracoccidioides spp. Serological studies to detect animal infection represent an excellent strategy for data on the agent's ecology. Although the state of Rio Grande do Sul (RS) is an endemic area for PCM in humans, there is scarce information available on the ecology of the agent in the region. This study aimed to investigate the infection by Paracoccidioides lutzii in animals living in RS, Brazil...
March 10, 2017: Mycoses
https://www.readbyqxmd.com/read/28285253/effect-of-self-esteem-on-social-interactions-during-the-ultimatum-game
#4
V Paz, E Nicolaisen-Sobesky, E Collado, S Horta, C Rey, M Rivero, P Berriolo, M Díaz, M Otón, A Pérez, G Fernández-Theoduloz, Á Cabana, V B Gradin
Self-esteem is an attitude formed by self-evaluation based on positive and negative aspects of oneself. Low self-esteem is a risk factor for psychiatric disorders and is especially associated with social difficulties. Recently, behavioral economics has allowed the quantitative study of social interactions. We investigated the association between self-esteem and interpersonal problems and whether self-esteem modulates behavior and emotions during an economic task, the Ultimatum Game (UG). In this task participants accept or reject fair/unfair monetary offers from others...
March 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28271379/laparoscopic-roux-en-y-gastric-bypass-after-open-vertical-banded-gastroplasty-in-patient-with-severe-gerd
#5
Peter Vorwald, Rafael Mauricio Restrepo Núñez, Maria Posada Gonzalez, Gabriel Salcedo Cabañas
This video shows a laparoscopic reintervention after an open, vertical banded gastroplasty in a 39-year-old woman presenting with untreatable GERD.
March 7, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28261044/cellular-regulation-of-amyloid-formation-in-aging-and-disease
#6
REVIEW
Esther Stroo, Mandy Koopman, Ellen A A Nollen, Alejandro Mata-Cabana
As the population is aging, the incidence of age-related neurodegenerative diseases, such as Alzheimer and Parkinson disease, is growing. The pathology of neurodegenerative diseases is characterized by the presence of protein aggregates of disease specific proteins in the brain of patients. Under certain conditions these disease proteins can undergo structural rearrangements resulting in misfolded proteins that can lead to the formation of aggregates with a fibrillar amyloid-like structure. Cells have different mechanisms to deal with this protein aggregation, where the molecular chaperone machinery constitutes the first line of defense against misfolded proteins...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28256218/switching-between-exonucleolysis-and-replication-by-t7-dna-polymerase-ensures-high-fidelity
#7
Tjalle P Hoekstra, Martin Depken, Szu-Ning Lin, Jordi Cabanas-Danés, Peter Gross, Remus T Dame, Erwin J G Peterman, Gijs J L Wuite
DNA polymerase catalyzes the accurate transfer of genetic information from one generation to the next, and thus it is vitally important for replication to be faithful. DNA polymerase fulfills the strict requirements for fidelity by a combination of mechanisms: 1) high selectivity for correct nucleotide incorporation, 2) a slowing down of the replication rate after misincorporation, and 3) proofreading by excision of misincorporated bases. To elucidate the kinetic interplay between replication and proofreading, we used high-resolution optical tweezers to probe how DNA-duplex stability affects replication by bacteriophage T7 DNA polymerase...
February 28, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28244777/obesidad-y-riesgo-de-infarto-de-miocardio-en-una-muestra-de-varones-europeos-el-%C3%A3-ndice-cintura-cadera-sesga-el-riesgo-real-de-la-obesidad-abdominal
#8
Ángel Martín Castellanos, María Dolores Cabañas Armesilla, Francisco Javier Barca Durán, Pedro Martín Castellanos, José Javier Gómez Barrado
Introducción: la obesidad es un factor de riesgo asociado al infarto de miocardio aunque el índice cintura-cadera ha mostrado mayor poder predictivo.Objetivo: análisis antropométrico Receiver Operating Characteristic(ROC) en infartados para identificar la fuerza discriminatoria de mediciones, obesidad, ratios cintura-cadera, ratios cintura-talla e índice de conicidad.Métodos: estudio caso-control de infarto miocárdico en varones europeos. Ciento doce casos/112 controles de 30-74 años fueron reclutados...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28220366/zirconia-implants-and-peek-restorations-for-the-replacement-of-upper-molars
#9
José María Parmigiani-Izquierdo, María Eugenia Cabaña-Muñoz, José Joaquín Merino, Arturo Sánchez-Pérez
BACKGROUND: One of the disadvantages of the zirconia implants is the lack of elasticity, which is increased with the use of ceramic or zirconia crowns. The consequences that could result from this lack of elasticity have led to the search for new materials with improved mechanical properties. CASE PRESENTATION: A patient who is a 45-year-old woman, non-smoker and has no medical record of interest with a longitudinal fracture in the palatal root of molar tooth 1...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28219634/management-of-chronic-spontaneous-urticaria-in-routine-clinical-practice-following-the-eaaci-ga-2-len-edf-wao-guidelines
#10
I Marín-Cabañas, L Berbegal-de Gracia, F de León-Marrero, P Hispán, J F Silvestre
INTRODUCTION: Chronic spontaneous urticaria is a prevalent and difficult-to-treat condition that has a very negative impact on patient quality of life. OBJECTIVE: To describe the epidemiological and clinical characteristics of patients presenting with chronic spontaneous urticaria and the response to treatment administered according to the EAACI/GA(2)LEN/EDF/WAO consensus guideline. MATERIAL AND METHOD: Descriptive cross-sectional study of all the patients with chronic spontaneous urticaria who consulted a skin allergy unit in the dermatology department of a tertiary hospital in Spain between July 2011 and July 2015...
February 20, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28181723/nanosecond-laser-assisted-nitrogen-doping-of-graphene-oxide-dispersions
#11
Dejan Kepić, Stefania Sandoval, Ángel Pérez Del Pino, Enikö György, Laura Cabana, Belén Ballesteros, Gerard Tobias
N-doped reduced graphene oxide (RGO) has been prepared in bulk form by laser irradiation of graphene oxide (GO) dispersed in an aqueous solution of ammonia. A pulsed Nd:YAG laser with emission wavelengths in the infrared (IR) 1064 nm, visible (VIS) 532 nm, and ultraviolet (UV) 266 nm spectral regions was employed for the preparation of the N-doped RGO samples. Regardless of the laser energy employed, the resulting material presents a higher fraction of pyrrolic nitrogen compared to nitrogen atoms in pyridinic and graphitic coordination...
February 9, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28174012/is-overweight-on-the-decrease-in-the-adult-population-differences-between-the-2009-and-2014-european-health-surveys-in-spain
#12
Paula Acevedo, Ana Isabel Mora-Urda, M Del Pilar Montero, M Dolores Cabañas, Consuelo Prado, M Dolores Marrodán
No abstract text is available yet for this article.
February 4, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28156650/organizational-factors-influencing-specialty-palliative-care-utilization-at-academic-cancer-centers
#13
Michael W Rabow, Megan Crowley-Makota, Mallory Marie Waters, Michelle Nkumsah, Douglas B White, Edward Chu, Cardinale B Smith, Robert Arnold
109 Background: Rates of early specialty palliative care utilization remain low, despite increasing familiarity and favorable attitudes amongst cancer center oncologists. In this context, understanding organizational barriers to specialty palliative care use becomes critical. METHODS: We conducted a qualitative interview study with 74 medical oncologists practicing at 3 U.S. academic cancer centers with well-established specialty palliative care clinics. The in-depth interview guide elicited experiences and views related to outpatient palliative care...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28127579/data-of-the-recombination-loss-mechanisms-analysis-on-al2o3-perc-cell-using-pc1d-and-pc2d-simulations
#14
Haibing Huang, Jun Lv, Yameng Bao, Rongwei Xuan, Shenghua Sun, Sami Sneck, Shuo Li, Chiara Modanese, Hele Savin, Aihua Wang, Jianhua Zhao
This data article is related to our recently published article ('20.8% industrial PERC solar cell: ALD Al2O3 rear surface passivation, efficiency loss mechanisms analysis and roadmap to 24%', Huang et al., 2017 [1]) where we have presented a systematic evaluation of the overall cell processing and a cost-efficient industrial roadmap for PERC cells. Aside from the information already presented in Huang et al., 2017 [1], here we provide data related to Sectin 3 in Huang et al., 2017 [1] concerning the analysis of the recombination losses׳ mechanisms by PC1D V5...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28122868/conformational-equilibria-and-intrinsic-affinities-define-integrin-activation
#15
Jing Li, Yang Su, Wei Xia, Yan Qin, Martin J Humphries, Dietmar Vestweber, Carlos Cabañas, Chafen Lu, Timothy A Springer
We show that the three conformational states of integrin α5β1 have discrete free energies and define activation by measuring intrinsic affinities for ligand of each state and the equilibria linking them. The 5,000-fold higher affinity of the extended-open state than the bent-closed and extended-closed states demonstrates profound regulation of affinity. Free energy requirements for activation are defined with protein fragments and intact α5β1 On the surface of K562 cells, α5β1 is 99.8% bent-closed. Stabilization of the bent conformation by integrin transmembrane and cytoplasmic domains must be overcome by cellular energy input to stabilize extension...
March 1, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28117494/the-seasonal-feeding-ecology-of-the-javan-slow-loris-nycticebus-javanicus
#16
Francis Cabana, Ellen Dierenfeld, Wirdateti Wirdateti, Giuseppe Donati, K A I Nekaris
OBJECTIVES: To describe the strategy employed by exudativorous primates during seasonal shifts in food abundance using the Javan slow loris as a model. Males and females may cope differently as well as exploit fallback foods in different proportions. MATERIALS AND METHODS: Observing 15 free ranging Javan slow lorises over a year, we quantified their seasonal diet and nutrient intake using intake rates. For gum intake rates, we conducted a trial with 10 captive Javan slow lorises measuring the length of time it took for them to ingest 10 g of gum...
January 24, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28116624/chemical-characterization-of-diesel-and-hydrotreated-vegetable-oil-hvo-soot-after-reactive-gas-probing-using-diffuse-reflectance-ftir-spectroscopy-drifts
#17
A Tapia, M S Salgado, M P Martín, J Rodríguez-Fernández, M J Rossi, B Cabañas
A chemical characterization of diesel and hydrotreated vegetable oil (HVO) soot has been developed using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) before and after the reaction with different probe gases. Samples were generated under combustion conditions corresponding to an urban operation mode of a diesel engine and were reacted with probe gas-phase molecules in a Knudsen flow reactor. Specifically, NH2OH, O3 and NO2 were used as reactants (probes) and selected according to their reactivities towards specific functional groups on the sample surface...
January 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28097684/feeding-asian-pangolins-an-assessment-of-current-diets-fed-in-institutions-worldwide
#18
Francis Cabana, Amy Plowman, Thai Van Nguyen, Shih-Chien Chin, Sung-Lin Wu, Hsuan-Yi Lo, Hirofumi Watabe, Fujio Yamamoto
Pangolins are ant specialists which are under intense threat from the illegal wildlife trade. Nutrition has notoriously been their downfall in captivity and is still an issue in regards to rescue and rehabilitation. We analyzed the nutrient content of diets used by institutions that are successfully keeping Asian pangolins and to assess the variety of the ingredients and nutrients, compared these with the nutritional requirements of potential nutritional model species. We performed intake studies at five institutions and also had data from three other institutions...
January 18, 2017: Zoo Biology
https://www.readbyqxmd.com/read/28049488/intracellular-trafficking-and-cellular-uptake-mechanism-of-phbv-nanoparticles-for-targeted-delivery-in-epithelial-cell-lines
#19
Juan P Peñaloza, Valeria Márquez-Miranda, Mauricio Cabaña-Brunod, Rodrigo Reyes-Ramírez, Felipe M Llancalahuen, Cristian Vilos, Fernanda Maldonado-Biermann, Luis A Velásquez, Juan A Fuentes, Fernando D González-Nilo, Maité Rodríguez-Díaz, Carolina Otero
BACKGROUND: Nanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale. One application of this technology is drug delivery systems based on nanoparticles obtained from natural or synthetic sources. An example of these systems is synthetized from poly(3-hydroxybutyrate-co-3-hydroxyvalerate), which is a biodegradable, biocompatible and a low production cost polymer. The aim of this work was to investigate the uptake mechanism of PHBV nanoparticles in two different epithelial cell lines (HeLa and SKOV-3)...
January 3, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28045261/intracellular-enzymes-contribution-to-the-biocatalytic-removal-of-pharmaceuticals-by-trametes-hirsuta
#20
Lounès Haroune, Sabrina Saibi, Hubert Cabana, Jean-Philippe Bellenger
The use of white rot fungi (WRF) for bioremediation of recalcitrant trace organic contaminants (TrOCs) is becoming greatly popular. Biosorption and lignin modifying enzymes (LMEs) are the most often reported mechanisms of action. Intracellular enzymes, such as cytochrome P450 (CYP450), have also been suggested to contribute. However, direct evidence of TrOCs uptake and intracellular transformation is lacking. The aim of this study was to evaluate the relative contribution of biosorption, extracellular LMEs activity, TrOCs uptake, and intracellular CYP450 on the removal of six nonsteroidal anti-inflammatories (NSAIs) by Trametes hirsuta...
January 3, 2017: Environmental Science & Technology
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