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Andranik Chavushyan, Meri Hovsepyan, Anna Boyajyan
This case study aimed to investigate effects of type III cryoglobulins isolated from the blood of patients with schizophrenia on the production of proinflammatory cytokines interleukin(IL)-1 β , IL-6 and tumor necrosis factor- α (TNF- α ), anti-inflammatory cytokine IL-10, and chemotactic cytokines IL-8 and monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cells (PBMCs). The experiments were performed in vitro using PBMCs healthy subjects and the blood of patients whit schizoprenia...
2013: Schizophrenia Research and Treatment
E Savaskan
Delirium is an acute confusion state of multifactorial genesis, commonly seen in the elderly with multimorbidity. Age and dementia, followed by infections and polypharmacy, are known as the most important risk factors. Increased disease interactions and medication use in the multimorbid elderly might precipitate delirium. Serious consequences of multimorbidity often are psychiatric diseases such as depression. Also anxiety and schizoprenia show a high comorbidity with somatic diseases. The therapy of elderly multimorbid patients is risky and must be preceded by profound assessment of all pathogenic factors...
December 12, 2012: Praxis
Eriko Mizuno, Misuzu Iwasaki, Ikue Sakai, Naotoshi Kamizawa
The purpose of this study was to clarify the sense of coherence (SOC) and quality of life (QOL) of caregivers of persons with schizoprenia. Thirty-four families were investigated using the SOC-13, the 26-item World Health Organization Quality of Life, and an interview guide. Family caregivers in their 50s, 60s, and 70s with higher SOC scores showed higher QOL scores; older groups showed higher mean SOC and QOL scores; and a significant difference in the scores for the environment domain was observed among the 3 groups...
August 2012: Archives of Psychiatric Nursing
Alex Hofer, Falko Biedermann, Nursen Yalcin, Wolfgang Fleischhacker
OBJECTIVE: Overview on the current knowledge regarding neurocognition and social cognition in patients with schizophrenia or mood disorders. METHODS: Selective literature research on deficits in neurocognition and social cognition intrinsic to schizophrenia and mood disorders, their occurrence and effects. RESULTS: Deficits in neurocognition and social cognition are more pronounced in patients with schizoprenia than in those with mood disorders...
2010: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
Péter Gaszner
Schizoprenia is not a consistent illness, but the symptoms free state do may achive with different methods. During the last fifty years the clinical psychopharmacology improved very quickly, but the psychotherapy and sociotherapy as well. The complex therapy of schizophrenia is a new method: the psychopharmacons together with psychotherapy (first of all with cognitive one), sociotherapy and psychiatric rehabilitation. During the acute or chronic phase of schizophrenia the psychopharmacons are the first line treatment, but the complex therapy is better...
March 2009: Neuropsychopharmacologia Hungarica
Michael Williams
Antipsychotics, the drugs used currently for the treatment of schizophrenia, produce their therapeutic effects via the blockade of dopamine receptors. These compounds are, however, limited in their therapeutic efficacy and have side effect liabilities that also limit their use. Agents that produce antipsychotic effects by enhancing NMDA receptor function represent a viable alternative to dopamine antagonists. D-serine, is the prototype of this approach acting as a positive allosteric modulator of the NMDA receptor to enhance antipsychotic efficacy in the clinic...
December 1, 2009: Biochemical Pharmacology
I Omer Barlas, Mesut Cetin, M Emin Erdal, Umit B Semiz, Cengiz Basoglu, M Ertan Ay, Hasan Herken, Ozcan Uzun
It is hypothesized that molecular components of dopaminergic system, especially the dopamine D3 receptor gene (DRD3), may play a crucial role in the pathophysiology of schizophrenia, because it is abundant in the limbic system of the brain and it binds antipsychotic drugs. Several groups attempted to find an association between a serine-to-glycine polymorphism of the DRD3 gene (Ser9Gly) and schizophrenia; however, the results were inconsistent. In this study, we aimed to investigate the relationship of the Serine/Glycine polymorphism of the DRD3 gene with therapeutic response to clozapine treatment between Turkish schizophrenia patients (N = 92) and healthy controls (N = 100)...
January 5, 2009: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
No abstract text is available yet for this article.
August 1949: Cincinnati Journal of Medicine
I-Chia Chien, Yiing-Jenq Chou, Ching-Heng Lin, Shin-Huey Bih, Pesus Chou, Hong-Jen Chang
As many as 96% of all residents of Taiwan have been enrolled in the National Health Insurance (NHI) program since 1996. The NHI database was used to examine the prevalence and incidence of schizoprenia. The National Health Research Institute provided a database of 200 432 random subjects, about 1% of the population, for study. By means of exclusion criteria, a random sample of 136 045 subjects as a fixed cohort dated from 1996-2001 was obtained. Those study subjects who had at least one service claim during these years for either ambulatory or inpatient care, with a principal diagnosis of schizophrenia, were identified...
December 2004: Psychiatry and Clinical Neurosciences
Sergi Ferré, Francisco Ciruela, Meritxell Canals, Daniel Marcellino, Javier Burgueno, Vicent Casadó, Joëlle Hillion, Maria Torvinen, Francesca Fanelli, Piero de Benedetti Pd, Steven R Goldberg, Michel Bouvier, Kjell Fuxe, Luigi F Agnati, Carme Lluis, Rafael Franco, Amina Woods
Emerging evidence shows that G protein-coupled receptors can form homo- and heteromers. These include adenosine A(2A) receptor-dopamine D(2) receptor heteromers, which are most probably localized in the dendritic spines of the striatopallidal GABAergic neurons, where they are in a position to modulate glutamatergic neurotransmission. The discovery of A(2A) receptor-dopamine D(2) receptor heteromers gives a frame for the well-known antagonistic interaction between both receptors, which is the bases for a new therapeutic approach for neuro-psychiatric disorders, such as Parkinson's disease and schizoprenia...
July 2004: Parkinsonism & related Disorders
Harold D Foster, Abram Hoffer
Cancer might be expected to be more common amongst schizophrenics than the general population. They frequently live in selenium deficient regions, have seriously compromised antioxidant defense systems and chain-smoke. The available literature on the cancer-schizoprenia relationship in patients from England, Wales, Ireland, Denmark, USA and Japan, however, strongly suggests that the reverse is true. One of the authors (Hoffer) has treated 4000 schizophrenics since 1952. Only four of these patients has developed cancer...
2004: Medical Hypotheses
No abstract text is available yet for this article.
March 1963: Archives of General Psychiatry
No abstract text is available yet for this article.
November 1959: Journal of Nervous and Mental Disease
D R Lara, M G Brunstein, E S Ghisolfi, M I Lobato, P Belmonte-de-Abreu, D O Souza
Adenosine has been proposed to contribute to the pathophysiology of schizoprenia and as a target for therapeutic intervention. In the lack of direct adenosine agonists, allopurinol may indirectly elevate adenosine levels by inhibiting degradation of purines. We report two cases of poorly responsive schizophrenic patients who improved considerably with add-on allopurinol 300 mg/day. Their clear clinical improvement warrant further investigation of allopurinol, as well as other purinergic strategies, for the treatment of schizophrenia...
July 2001: International Clinical Psychopharmacology
A Guidotti, C Pesold, E Costa
Reelin (Reln) is expressed in specific GABAergic neurons in layer I and II of neocortex, and is secreted into the extracellular matrix where it surrounds dendrites, spines and neurite arborizations, and binds to integrin receptors located on post-synaptic densities of apical dendritic spines. Experiments in rodents (including wild type or reeler heterozygous mice) and non-human primates suggest the Reln secreted in the extracellular matrix of neocortex, via integrin receptors, modulates the function of the adaptor protein DAB1(drosophila disable-gene) homologous product) thereby participating in dynamic processes associated with plasticity changes in dendrites, dendritic spines and their synapses...
October 2000: Neurochemical Research
A Abi-Dargham, M Laruelle, J Krystal, C D'Souza, S Zoghbi, R M Baldwin, J Seibyl, O Mawlawi, G de Erasquin, D Charney, R B Innis
Deficits in gamma-amino-butyric acid (GABA) neurotransmitter systems have been implicated in the pathophysiology of schizophrenia for more than two decades. Previous postmortem and in vivo studies of benzodiazepine (BDZ) receptor density have reported alterations in several brain regions of schizophrenic patients. The goal of this study was to better characterize possible alterations of the in vivo regional distribution volume (VT) of BDZ receptors in schizoprenia, using the selective BDZ antagonist [123I]iomazenil and single photon emission computerized tomography (SPECT)...
June 1999: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
J Modestin
An examination of the literature concerning the borderline reveals that different authors, using different concepts of the borderline state, are describing different patient groups. Related to the background of the generally accepted psychiatric nosological classification, three borderline concepts are clearly discernible: (1) borderline equated with a forme fruste of schizoprenia, (2) borderline equated with a general category of personality disorder (psychopathy) and (3) borderline equated with a special form of personality disorder...
February 1980: Acta Psychiatrica Scandinavica
G C Sedvall, B Wode-Helgodt
In 36 drug-free schizophrenic patients, lumbar CSF was analyzed by mass fragmentography for the major monoaminergic transmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). High or deviant concentrations of 5-HIAA were significantly related to a family history of schizophrenia. For patients with deviant 5-HIAA levels, the probability for a family history of schizophrenia was eight times higher than in subjects with normal values. High concentrations of HVA also tended to be significantly related to a family history of schizoprenia...
October 1980: Archives of General Psychiatry
S C Goldberg
The author assesses the current status of research on psychopharmacological and psychosocial interventions with schizophrenic patients. Among the issues discussed are the needs to validate the diagnosis of schizoprenia; to reduce sample heterogeneity by defining subgroups based on meaningful response to drug treatment, long-term course, family history, neurologic soft signs, etc.; to characterize the subgroup of patients who do not respond to or do not require neuroleptic treatment; to determine the prevalence of tardive dyskinesia on a national and regional basis; to use blood levels of neuroleptic drugs as indices of whether individual patients are receiving adequate dosages; to investigate further the question of drug compliance and optimal duration of maintenance therapy; and finally to demonstrate how drug treatment and social skills training interact with each other...
1980: Schizophrenia Bulletin
M R Ogle, M J Miller
Last year's introduction of clozapine, an atypical antipsychotic, in the United States was the most significant advance in schizoprenia treatment since the advent of chlopromazine in the 1950s. However, clozapine has a disturbingly high incidence of agranulocytosis. The drug manufacturer designed a complex and expensive mandatory blood monitoring system that was dismantled after public pressure earlier this year. There is hope that clozapine will become more widely available to schizoprenic patients.
September 1991: Indiana Medicine: the Journal of the Indiana State Medical Association
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